heart atria

Summary

Summary: The chambers of the heart, to which the BLOOD returns from the circulation.

Top Publications

  1. ncbi Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Circulation 106:2091-7. 2002
  2. pmc HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
    W C Claycomb
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 95:2979-84. 1998
  3. ncbi Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
    Ulrich Schotten
    Department of Physiology, University Maastricht, Maastricht, The Netherlands
    Physiol Rev 91:265-325. 2011
  4. ncbi Electrical, contractile and structural remodeling during atrial fibrillation
    Maurits Allessie
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Cardiovasc Res 54:230-46. 2002
  5. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
  6. ncbi Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation
    Michael H Gollob
    Arrhythmia Research Laboratory and Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada
    N Engl J Med 354:2677-88. 2006
  7. ncbi PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Muenster, Germany
    Circ Cardiovasc Genet 4:123-33. 2011
  8. ncbi Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker
    Natalie J Chandler
    Cardiovascular Research Group, Faculty of Medical and Human Sciences, University of Manchester, Core Technology Facility, 46 Grafton St, Manchester M139NT, United Kingdom
    Circulation 119:1562-75. 2009
  9. ncbi Left atrial strain and strain rate in patients with paroxysmal and persistent atrial fibrillation: relationship to left atrial structural remodeling detected by delayed-enhancement MRI
    Suman S Kuppahally
    Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Circ Cardiovasc Imaging 3:231-9. 2010
  10. ncbi Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing
    C M Chang
    Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
    Circulation 103:22-5. 2001

Detail Information

Publications283 found, 100 shown here

  1. ncbi Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Circulation 106:2091-7. 2002
    ..Structural changes, like atrial fibrosis, may increase the likelihood of atrial fibrillation (AF) occurring in response to triggering events. The influence of isolated atrial amyloidosis (IAA) is largely unknown...
  2. pmc HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
    W C Claycomb
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 95:2979-84. 1998
    ..HL-1 cells represent a cardiac myocyte cell line that can be repeatedly passaged and yet maintain a cardiac-specific phenotype...
  3. ncbi Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
    Ulrich Schotten
    Department of Physiology, University Maastricht, Maastricht, The Netherlands
    Physiol Rev 91:265-325. 2011
    ..We pay attention to translation of pathophysiological insights gained from in vitro experiments and animal models to patients. Also, suggestions for future research objectives and therapeutical implications are discussed...
  4. ncbi Electrical, contractile and structural remodeling during atrial fibrillation
    Maurits Allessie
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Cardiovasc Res 54:230-46. 2002
    ..New strategies for prevention and termination of AF should be build on our knowledge of the mechanisms and time course of AF-induced atrial remodeling...
  5. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
    ..In patients without a history of atrial arrhythmias or valvular heart disease, LA volume expressed the severity of diastolic dysfunction and provided an index of cardiovascular risk and disease burden...
  6. ncbi Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation
    Michael H Gollob
    Arrhythmia Research Laboratory and Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada
    N Engl J Med 354:2677-88. 2006
    ..We hypothesized that idiopathic atrial fibrillation has a genetic basis and that tissue-specific mutations in GJA5, the gene encoding connexin 40, may predispose the atria to fibrillation...
  7. ncbi PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Muenster, Germany
    Circ Cardiovasc Genet 4:123-33. 2011
    ..We therefore tested whether adult hearts express PITX2 and whether variation in expression affects cardiac function...
  8. ncbi Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker
    Natalie J Chandler
    Cardiovascular Research Group, Faculty of Medical and Human Sciences, University of Manchester, Core Technology Facility, 46 Grafton St, Manchester M139NT, United Kingdom
    Circulation 119:1562-75. 2009
    ..The aims of the present study were to investigate the expression of ion channels in the human SN and to use the data to predict electrical activity...
  9. ncbi Left atrial strain and strain rate in patients with paroxysmal and persistent atrial fibrillation: relationship to left atrial structural remodeling detected by delayed-enhancement MRI
    Suman S Kuppahally
    Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Circ Cardiovasc Imaging 3:231-9. 2010
    ..Because of limitations with current noninvasive imaging techniques, the relationship between LA structure and function is not well understood...
  10. ncbi Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing
    C M Chang
    Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
    Circulation 103:22-5. 2001
    ..The magnitude of nerve sprouting and hyperinnervation was higher in the right atrium than in the left atrium...
  11. ncbi Intra-atrial pressure increases rate and organization of waves emanating from the superior pulmonary veins during atrial fibrillation
    Jerome Kalifa
    Institute for Cardiovascular Research, Department of Pharmacology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA
    Circulation 108:668-71. 2003
    ..We hypothesized that elevation of intra-atrial pressure elicits high-frequency and spatio-temporally organized left atrial (LA) sources emanating from the superior pulmonary veins...
  12. ncbi Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation
    Brett Burstein
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, and Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 51:802-9. 2008
    ....
  13. ncbi Echocardiographic evaluation of left atrial size and function: current understanding, pathophysiologic correlates, and prognostic implications
    Dominic Y Leung
    Liverpool Hospital, University of New South Wales, Sydney, New South Wales, Australia
    Am Heart J 156:1056-64. 2008
    ..In addition, an overview of the implications and clinical relevance of the findings of an enlarged left atrium, from currently available literature, is presented...
  14. ncbi Atrial fibrillation and atrial fibrosis
    Alex Y Tan
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cardiovasc Pharmacol 57:625-9. 2011
    ..This article reviews the role that atrial fibrosis plays in AF, the mechanisms of atrial fibrosis, and emerging therapeutic approaches to AF aimed at attenuating atrial fibrosis...
  15. pmc Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation
    Eleonora Grandi
    Department of Pharmacology, University of California, Davis, 451 Health Sciences Dr, GBSF Room 3513, Davis, CA 95616 8636, USA
    Circ Res 109:1055-66. 2011
    ..Understanding atrial fibrillation (AF) requires integrated understanding of ionic currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited...
  16. ncbi Role of Rac1 GTPase activation in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 50:359-67. 2007
    ..We aimed to study the role of Rac1 GTPase in atrial fibrillation (AF)...
  17. pmc Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1
    Sander Verheule
    Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Ind, USA
    Circ Res 94:1458-65. 2004
    ..Thus, in this transgenic mouse model, selective atrial fibrosis is sufficient to increase AF inducibility...
  18. ncbi A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate
    Koonlawee Nademanee
    Pacific Rim Electrophysiology Research Institute, Inglewood, California 90301, USA
    J Am Coll Cardiol 43:2044-53. 2004
    ..We sought to test the hypothesis that complex fractionated electrograms (CFAEs) recorded during atrial fibrillation (AF) could be used as target sites for catheter ablation of AF...
  19. ncbi Electropathological substrate of longstanding persistent atrial fibrillation in patients with structural heart disease: epicardial breakthrough
    Natasja M S de Groot
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
    Circulation 122:1674-82. 2010
    ..During persistent atrial fibrillation (AF), waves with a focal spread of activation are frequently observed. The origin of these waves and their relevance for the persistence of AF are unknown...
  20. ncbi Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation
    C A Carnes
    College of Pharmacy, Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio, USA
    Circ Res 89:E32-8. 2001
    ..The full text of this article is available at http://www.circresaha.org...
  21. pmc Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance
    Alicia M Maceira
    Cardiac Imaging Unit, ERESA, Valencia, Spain
    J Cardiovasc Magn Reson 12:65. 2010
    ..For definition of the best 2D images-derived predictors of LA enlargement, we studied 120 patients (60 men, 60 women; age range 20 to 80 years) with a clinical indication for CMR...
  22. ncbi Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation
    Grace Casaclang-Verzosa
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55901, USA
    J Am Coll Cardiol 51:1-11. 2008
    ..In this review, we describe the mechanisms involved in LA remodeling and highlight the existing and potential therapeutic options for its reversal, and implications for AF development...
  23. ncbi The left atrium: a biomarker of chronic diastolic dysfunction and cardiovascular disease risk
    Pamela S Douglas
    J Am Coll Cardiol 42:1206-7. 2003
  24. ncbi Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure
    Yung Hsin Yeh
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Circ Arrhythm Electrophysiol 1:93-102. 2008
    ..Focal sources of unknown mechanism have been described in CHF-related atrial fibrillation. The authors hypothesized that abnormal calcium (Ca(2+)) handling contributes to the CHF-related atrial arrhythmogenic substrate...
  25. ncbi Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:172-8. 2012
    ..Renal denervation displays antiarrhythmic effects by reducing NTP-induced AERP shortening and inhibits postapneic BP rises associated with obstructive events...
  26. ncbi Atrial remodeling in obstructive sleep apnea: implications for atrial fibrillation
    Hany Dimitri
    Centre for Heart Rhythm Disorders CHRD, Discipline of Medicine, University of Adelaide, Adelaide, Australia
    Heart Rhythm 9:321-7. 2012
    ..There is a known association between obstructive sleep apnea (OSA) and atrial fibrillation (AF); however, how OSA affects the atrial myocardium is not well described...
  27. pmc Sarcoplasmic reticulum and L-type Ca²⁺ channel activity regulate the beat-to-beat stability of calcium handling in human atrial myocytes
    Anna Llach
    Cell Physiology Laboratory, Cardiovascular Research Centre CSIC ICCC, and Cardiology Department, Hospital de Santa Creu i Sant Pau, 08025 Barcelona, Spain
    J Physiol 589:3247-62. 2011
    ....
  28. pmc Identification and functional characterization of cardiac pacemaker cells in zebrafish
    Federico Tessadori
    Hubrecht Institute KNAW, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e47644. 2012
    ..We have thereby identified an evolutionary conserved, structural and molecular distinguishable component of the cardiac conduction system in a lower vertebrate...
  29. ncbi Cardiac connexins and impulse propagation
    John A Jansen
    Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, The Netherlands
    J Mol Cell Cardiol 48:76-82. 2010
    ..This review will follow the cardiac impulse on its path through the heart and recapitulate the role of the different connexins in the different cardiac compartments...
  30. ncbi Optimal site for atrial lead implantation in myotonic dystrophy patients: the role of Bachmann's Bundle stimulation
    Gerardo Nigro
    Chair of Cardiology, Second University of Naples Monaldi Hospital, Naples, Italy
    Pacing Clin Electrophysiol 31:1463-6. 2008
    ..The aim of this study was to identify the optimal site for atrial lead implantation in myotonic dystrophy type 1 (MD1) patients...
  31. pmc Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation
    Mayilvahanan Shanmugam
    Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 165 South Orange Ave, MSB G609, Newark, NJ 07003, USA
    Biochem Biophys Res Commun 410:97-101. 2011
    ..The selective downregulation of SLN and enhanced SR Ca(2+) uptake in human AF suggest that SLN downregulation could play an important role in abnormal intracellular Ca(2+) cycling in atrial pathology...
  32. ncbi Increased left atrial volume index: potent biomarker for first-ever ischemic stroke
    Kaniz Fatema
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1107-15. 2008
    ..To establish the incidence and correlation of increased left atrial volume index (LAVI) in patients with first-ever ischemic stroke...
  33. ncbi Assessment of non-invasive time and frequency atrial fibrillation organization markers with unipolar atrial electrograms
    Raul Alcaraz
    Innovation in Bioengineering Research Group, University of Castilla La Mancha, Campus Universitario, Cuenca, Spain
    Physiol Meas 32:99-114. 2011
    ..001). These outcomes together with interesting linear relationships found among the parameters suggest that AF regularity estimated via SampEn and f wave amplitude can non-invasively characterize the epicardial activity related to AF...
  34. pmc A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation
    Robert C Wirka
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Circ Arrhythm Electrophysiol 4:87-93. 2011
    ....
  35. pmc Repolarization alternans reveals vulnerability to human atrial fibrillation
    Sanjiv M Narayan
    VAMC Cardiology, University of California San Diego, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    Circulation 123:2922-30. 2011
    ..We hypothesized that beat-to-beat oscillations in APD may explain AF substrates, and why vulnerability to AF forms a spectrum from control subjects without AF to patients with paroxysmal then persistent AF...
  36. ncbi Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age
    Pyotr G Platonov
    Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden
    J Am Coll Cardiol 58:2225-32. 2011
    ..The purpose of this study was to assess the association between structural changes in human atria, age, and history of atrial fibrillation (AF)...
  37. ncbi Does Bachmann's bundle pacing prevent atrial fibrillation in myotonic dystrophy type 1 patients? A 12 months follow-up study
    Gerardo Nigro
    Cardiology, Second, University of Naples Monaldi Hospital, Naples, Italy
    Europace 12:1219-23. 2010
    ..Aim of our study was to evaluate the preventive effects of interatrial septum pacing in the Bachmann's Bundle region on atrial fibrillation (AF) in MD1 patients during 12 months follow up period...
  38. pmc Impaired Ca2+ homeostasis is associated with atrial fibrillation in the alpha1D L-type Ca2+ channel KO mouse
    Salvatore Mancarella
    Molecular and Cellular Cardiology Program, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY 11209, USA
    Am J Physiol Heart Circ Physiol 295:H2017-24. 2008
    ..These findings provide new insights into the mechanism leading to atrial electrical dysfunction in the alpha1D KO mice...
  39. ncbi Left atrial volume index in highly trained athletes
    Antonello D'Andrea
    Second University of Naples, Naples, Italy
    Am Heart J 159:1155-61. 2010
    ..Increase of left atrial (LA) diameter in trained athletes has been regarded as another component of the "athlete's heart"...
  40. ncbi Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes
    Leif Hove-Madsen
    Cell Physiology Laboratory, Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Circulation 110:1358-63. 2004
    ..Therefore, an association may exist between spontaneous SR Ca2+ release and initiation of atrial fibrillation (AF), but this has not yet been reported...
  41. ncbi Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model
    Marc D Lemoine
    Department of Medicine, Montreal Heart Institute Research Centre and Université de Montréal, 5000 Belanger Street East, Montreal, QC, Canada H1T 1C8
    Cardiovasc Res 92:67-74. 2011
    ..Atrial cellular arrhythmia mechanisms have not been defined in congenital LQTS. Therefore, we studied atrial cardiomyocyte electrophysiology in mice with an LQTS3 SCN5A inactivation-impairing mutation (ΔKPQ heterozygotes)...
  42. ncbi Chiari's network: review of the literature
    Marios Loukas
    Department of Anatomical Sciences, School of Medicine, St George s University, Grenada, West Indies
    Surg Radiol Anat 32:895-901. 2010
    ..While initially discovered and researched using autopsy dissections, Chiari's network is often found as an incidental finding on diagnostic imaging studies, thus providing new methods for studying its incidence and clinical significance...
  43. ncbi Aging-related increase to inducible atrial fibrillation in the rat model
    Hideki Hayashi
    Department of Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Cardiovasc Electrophysiol 13:801-8. 2002
    ..We hypothesized that aged rats are suitable for study of aging-related AF and that partial atrial cellular uncoupling induced with heptanol in young rats mimics aging-related AF...
  44. pmc Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study
    Madison S Spach
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Heart Rhythm 4:175-85. 2007
    ..How such gradients occur naturally in aging atrial tissue is unknown...
  45. ncbi Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis
    Evgeny P Anyukhovsky
    Department of Pharmacology, Center for Molecular Therapeutics, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, PH 7 West 321, New York, NY 10032, USA
    Cardiovasc Res 54:462-9. 2002
    ..The incidence of atrial fibrillation increases with age. We hypothesized that aging-associated changes in the atrial action potential (AP) and conduction velocity provide a substrate for abnormal conduction and arrhythmogenesis...
  46. ncbi Obesity and the risk of new-onset atrial fibrillation
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 292:2471-7. 2004
    ..Obesity is associated with atrial enlargement and ventricular diastolic dysfunction, both known predictors of atrial fibrillation (AF). However, it is unclear whether obesity is a risk factor for AF...
  47. ncbi Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure
    Tae Joon Cha
    5000 Belanger St East, Montreal, Quebec, H1T 1C8, Canada
    Circulation 109:412-8. 2004
    ..The relative importance of ionic versus structural remodeling in CHF-related atrial fibrillation (AF) is controversial...
  48. ncbi Conotruncal myocardium arises from a secondary heart field
    K L Waldo
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Development 128:3179-88. 2001
    ..The addition of a secondary myocardium to the primary heart tube provides a new framework for understanding several null mutations in mice that cause defective heart development...
  49. pmc A role for RGS10 in beta-adrenergic modulation of G-protein-activated K+ (GIRK) channel current in rat atrial myocytes
    Kirsten Bender
    Institute of Physiology, Ruhr University Bochum, D 44780 Bochum, Germany
    J Physiol 586:2049-60. 2008
    ..Moreover, RGS10, via PKA-dependent phosphorylation, enables a crosstalk between beta-adrenergic and muscarinic cholinergic signalling...
  50. ncbi Inflammation of atrium after cardiac surgery is associated with inhomogeneity of atrial conduction and atrial fibrillation
    Yosuke Ishii
    Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO, USA
    Circulation 111:2881-8. 2005
    ..Atrial fibrillation (AF) is common after cardiac surgery. Abnormal conduction is an important substrate for AF. We hypothesized that atrial inflammation alters atrial conduction properties...
  51. ncbi Histopathological features of the resected left atrial appendage as predictors of recurrence after surgery for atrial fibrillation in valvular heart disease
    Tsunenori Saito
    Nippon Medical School, Department of Pathology, Toranomon Hospital, Tokyo, Japan
    Circ J 71:70-8. 2007
    ..A histopathological assessment of left atrial appendages (LAA) resected during surgical treatment for atrial fibrillation (AF) was made, with the aim of improving the prediction of postoperative AF recurrence...
  52. ncbi Expression of angiotensin II receptors in human left and right atrial tissue in atrial fibrillation with and without underlying mitral valve disease
    Andreas Boldt
    University of Leipzig, Heart Center, Cardiovascular Surgery, Cardiology, Leipzig, Germany
    J Am Coll Cardiol 42:1785-92. 2003
    ..TIVES: We postulated a change of angiotensin II receptor subtype expression in patients with lone atrial fibrillation (AF) and AF with underlying mitral valve disease (MVD) both compared with sinus rhythm (SR)...
  53. ncbi Presence of left-to-right atrial frequency gradient in paroxysmal but not persistent atrial fibrillation in humans
    Sorin Lazar
    Electrophysiology Division, Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA
    Circulation 110:3181-6. 2004
    ..We hypothesized that human AF would also manifest a left-to-right atrial frequency gradient...
  54. ncbi Cardiac hydatid cysts with intracavitary expansion
    M Kaplan
    Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey
    Ann Thorac Surg 71:1587-90. 2001
    ..Hydatid cyst disease is a significant health problem for undeveloped and developing countries. Although cardiac involvement is rare, early diagnosis and treatment of this situation is important...
  55. ncbi Mechanoelectric feedback leads to conduction slowing and block in acutely dilated atria: a modeling study of cardiac electromechanics
    Nico H L Kuijpers
    Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands
    Am J Physiol Heart Circ Physiol 292:H2832-53. 2007
    ..Our observations are in agreement with experimental results and explain the large differences in intra-atrial conduction, as well as the increased inducibility of atrial fibrillation in acutely dilated atria...
  56. ncbi Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation
    Erich Wettwer
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Circulation 110:2299-306. 2004
    ....
  57. pmc Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization
    Mary M Maleckar
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
    Biophys J 97:2179-90. 2009
    ..Our model provides mechanistic insight into the consequences of heterologous cell coupling on hAM electrophysiology, and can be extended to evaluate these implications at both tissue and organ levels...
  58. pmc Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation
    Volker Rudolph
    1Department of General and Interventional Cardiology and Cardiovascular Research Center, University Heart Center, Hamburg, Germany
    Nat Med 16:470-4. 2010
    ..Our data demonstrate that MPO is a crucial prerequisite for structural remodeling of the myocardium, leading to an increased vulnerability to atrial fibrillation...
  59. ncbi Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans
    Prashanthan Sanders
    Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia
    Circulation 108:1461-8. 2003
    ..However, the electrophysiological substrate for AF in humans with CHF remains unknown. We evaluated the electrophysiological and electroanatomic characteristics of the atria in patients with CHF...
  60. ncbi Structural remodelling during chronic atrial fibrillation: act of programmed cell survival
    V L Thijssen
    Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
    Cardiovasc Res 52:14-24. 2001
    ..We briefly describe the underlying molecular remodelling. and possible mechanisms responsible for remodelling involving calcium overload and stretch are presented...
  61. ncbi Atrial but not ventricular fibrosis in mice expressing a mutant transforming growth factor-beta(1) transgene in the heart
    H Nakajima
    Herman B Wells Center for Pediatric Research and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Ind, USA
    Circ Res 86:571-9. 2000
    ..These data suggest that increased TGF-beta(1) activity by itself is insufficient to promote ventricular fibrosis in the adult mouse ventricle...
  62. ncbi Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat
    Christophe Boixel
    INSERM Unité 460, Paris, France
    J Am Coll Cardiol 42:336-44. 2003
    ..The purpose of this study was to determine the pathogenic factors and molecular mechanisms involved in fibrosis of the atria...
  63. ncbi Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences
    Brett Burstein
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circulation 117:1630-41. 2008
    ..In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological stimuli has not been examined...
  64. ncbi Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarland, Homburg Saar, Germany
    J Am Coll Cardiol 55:469-80. 2010
    ..We studied the signal transduction of atrial structural remodeling that contributes to the pathogenesis of atrial fibrillation (AF)...
  65. ncbi Two-dimensional speckle-tracking echocardiography of the left atrium: feasibility and regional contraction and relaxation differences in normal subjects
    Rita Vianna-Pinton
    Divisions of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    J Am Soc Echocardiogr 22:299-305. 2009
    ....
  66. ncbi Atrial L-type Ca2+ currents and human atrial fibrillation
    D R Van Wagoner
    Department of Cardiology and Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circ Res 85:428-36. 1999
    ..The reduction in functional I(Ca) density in myocytes from the atria of chronic AF patients may thus be an adaptive response to the arrhythmia-induced calcium overload...
  67. ncbi Induction of heat shock response protects the heart against atrial fibrillation
    Bianca J J M Brundel
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada
    Circ Res 99:1394-402. 2006
    ..These findings advance our understanding of the biochemical determinants of AF and suggest the possibility that HSP induction may be an interesting novel approach to preventing clinical AF...
  68. ncbi Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation
    Niels Voigt
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Circ Arrhythm Electrophysiol 3:472-80. 2010
    ..Unequal left-to-right distribution of inward rectifier K(+) currents has been suggested to underlie this dominant frequency gradient, but this hypothesis has never been tested in humans...
  69. ncbi Adipocytes modulate the electrophysiology of atrial myocytes: implications in obesity-induced atrial fibrillation
    Yung Kuo Lin
    Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin Lung Road Sec 3, Taipei, Taiwan
    Basic Res Cardiol 107:293. 2012
    ..In conclusion, adipocytes can directly modulate the electrophysiological properties and ion currents, causing higher arrhythmogenesis in LA myocytes...
  70. ncbi Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Homburg Saar D 66421, Germany
    Cardiovasc Res 87:485-93. 2010
    ..The small GTPase Rac1 seems to play a role in the pathogenesis of atrial fibrillation (AF). The aim of the present study was to characterize the effects of Rac1 overexpression on atrial electrophysiology...
  71. ncbi CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation
    Stefan Neef
    Department of Cardiology and Pneumology Heart Center, Georg August University Gottingen, Robert Koch Strasse 40, Gottingen, Germany
    Circ Res 106:1134-44. 2010
    ..In ventricular myocardium, ryanodine receptor type 2 (RyR2) phosphorylation by Ca(2+)/calmodulin-dependent protein kinase (CaMK)II is emerging as an important mechanism for SR Ca(2+) leak...
  72. ncbi In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain
    J Am Coll Cardiol 55:2346-54. 2010
    ..The purpose of this study was to compare the voltage-dependent K(+) currents of human cells of the right and left atria and determine whether electrical remodeling produced by chronic atrial fibrillation (CAF) is chamber-specific...
  73. pmc Cardiovascular magnetic resonance and PET-CT of left atrial paraganglioma
    Anderanik Tomasian
    Department of Radiological Sciences, University of California at Los Angeles, USA
    J Cardiovasc Magn Reson 12:1. 2010
    ....
  74. ncbi Discrepant electrophysiological characteristics and calcium homeostasis of left atrial anterior and posterior myocytes
    Kazuyoshi Suenari
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Basic Res Cardiol 106:65-74. 2011
    ..In conclusion, LA posterior myocytes contain a high arrhythmogenic potential and distinctive electrophysiological characteristics, which may contribute to the pathophysiology of AF...
  75. pmc Properties of two human atrial cell models in tissue: restitution, memory, propagation, and reentry
    Elizabeth M Cherry
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Theor Biol 254:674-90. 2008
    ..This finding implies that the formulation of intracellular calcium processes is as important to producing realistic models as transmembrane currents...
  76. ncbi The HMG-CoA reductase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model
    Koichiro Kumagai
    School of Internal Medicine, Department of Cardiology, Fukuoka University Hospital, 7 45 1, Nanakuma, Jonan, Fukuoka 814 0180, Japan
    Cardiovasc Res 62:105-11. 2004
    ..Statins reduce C-reactive protein (CRP) levels. However, the effect of statin on atrial fibrillation (AF) is unclear. The purpose of the present study was to evaluate the effect of statin on AF in a canine sterile pericarditis model...
  77. ncbi The importance of atrial structure and fibers
    S Y Ho
    Cardiac Morphology Unit, National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, Dovehouse Street, London, United Kingdom
    Clin Anat 22:52-63. 2009
    ..These are important features in intra- and interatrial conduction...
  78. ncbi Arrhythmogenic consequences of action potential duration gradients in the atria
    Marc Etienne Ridler
    Department of Geography and Geology, University of Copenhagen, Copenhagen, Denmark
    Can J Cardiol 27:112-9. 2011
    ..This gradient has been postulated to be cardioprotective by reducing repolarization gradients...
  79. ncbi Is there an anatomical substrate for idiopathic paroxysmal atrial fibrillation? A case-control echocardiographic study
    Marta Sitges
    Department of Cardiology, Thorax Institute, Hospital Clinic, IDIBAPS, University of Barcelona, Villarroel 136, 08036 Barcelona, Spain
    Europace 9:294-8. 2007
    ..Its mechanisms may be complex and are poorly understood. The aim of the study was to evaluate whether patients with idiopathic AF have any structural abnormality that may explain the occurrence of AF...
  80. ncbi Witnessed migration of a giant, free-floating thrombus into the right atrium during echocardiography, leading to fatal pulmonary embolism
    Gulizar Sokmen
    Department of Cardiology, Medicine Faculty of Kahramanmaraş Sütçü Imam University, Kahramanmaras, Turkey
    Turk Kardiyol Dern Ars 37:41-3. 2009
    ..All resuscitation efforts including open heart massage were unsuccessful. The thrombotic material removed from the right atrium was 150 mm in length. Pathological examination showed the mass to be a thrombus...
  81. ncbi Transient Super-Himalayan P-waves in severe pulmonary emphysema
    Lovely Chhabra
    Department of Internal Medicine, Saint Vincent Hospital, University of Massachusetts Medical School, Worcester, MA, USA
    J Electrocardiol 45:26-7. 2012
    ..Transient Himalayan P-waves of quite such amplitude have not been reported previously, which makes our case the first such report in literature...
  82. ncbi Factors associated with the development of atrial fibrillation in patients with rheumatic mitral stenosis
    Mehmet Ozaydin
    Department of Cardiology, Suleyman Demirel University, Kurtulus Mah, 122 cad Hatice Halici apt no 126, 32040, Isparta, Turkey
    Int J Cardiovasc Imaging 26:547-52. 2010
    ..68; 95% confidence interval, 1.32-2.14). Present study suggests that High sensitivity C reactive protein, N-terminal of brain natriuretic peptide precursor and left atrial diameter are associated with development AF in patients with MS...
  83. ncbi Strain rate imaging for functional quantification of the left atrium: atrial deformation predicts the maintenance of sinus rhythm after catheter ablation of atrial fibrillation
    Carsten Schneider
    Department of Cardiology, Asklepios Hospital St Georg, Hamburg, Germany
    Eur Heart J 29:1397-409. 2008
    ....
  84. ncbi Normal reference ranges for left and right atrial volume indexes and ejection fractions obtained with real-time three-dimensional echocardiography
    Erlend Aune
    Department of Cardiology, Vestfold Hospital Trust, NO 3103 Toensberg, Norway
    Eur J Echocardiogr 10:738-44. 2009
    ....
  85. ncbi Differences in repeating patterns of complex fractionated left atrial electrograms in longstanding persistent atrial fibrillation as compared with paroxysmal atrial fibrillation
    Edward J Ciaccio
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA
    Circ Arrhythm Electrophysiol 4:470-7. 2011
    ..It was hypothesized that this may result from a greater degree of repetitiveness in CFAE patterns at disparate left atrial (LA) sites in longstanding AF...
  86. ncbi Physician-directed patient self-management of left atrial pressure in advanced chronic heart failure
    Jay Ritzema
    University of Otago, Christchurch, New Zealand
    Circulation 121:1086-95. 2010
    ..We conducted a prospective, observational, first-in-human study of a physician-directed patient self-management system targeting left atrial pressure...
  87. ncbi Temporal variation in optimal atrioventricular and interventricular delay during cardiac resynchronization therapy
    Maria Cristina Porciani
    Division of Cardiology, Clinica Medica Careggi, Florence, Italy
    J Card Fail 12:715-9. 2006
    ..Tailored atrioventricular delay (AVd) and interventricular delay (VVd) combination improves hemodynamics in patients treated with cardiac resynchronization therapy (CRT). Whether tailored AVd-VVd combination changes over time is not known...
  88. ncbi Characterization and comparison of Na+, K+ and Ca2+ currents between myocytes from human atrial right appendage and atrial septum
    Dongmei Gong
    Department of Pharmacology, Harbin Medical University, Harbin, PR China
    Cell Physiol Biochem 21:385-94. 2008
    ..These differences provided a rational explanation for the different efficacies in treating atrial fibrillation by atrial pacing in RAA and AS regions...
  89. ncbi Direct left atrial pressure monitoring in ambulatory heart failure patients: initial experience with a new permanent implantable device
    Jay Ritzema
    Department of Cardiology, Parkside West, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand 8001
    Circulation 116:2952-9. 2007
    ..We describe the first human experience with a permanently implantable, direct left atrial pressure (LAP) monitoring system in ambulatory patients with chronic heart failure...
  90. ncbi Angiotensin II-induced changes of calcium sparks and ionic currents in human atrial myocytes: potential role for early remodeling in atrial fibrillation
    Natig Gassanov
    Department of Internal Medicine III, University of Cologne, Kerpener Str 62, Cologne 50937, Germany
    Cell Calcium 39:175-86. 2006
    ..Atrial angiotensin II (ANG II) levels have been shown to be increased in atrial fibrillation (AF). The purpose of the study was to evaluate a potential role of ANG II in the early remodeling and susceptibility to chronicization of AF...
  91. ncbi Pulmonary embolization as primary manifestation of hepatocellular carcinoma with intracardiac penetration: a case report
    Elod Papp
    1st Department of Medicine, University of Pecs Medical School, H 7624 Pecs, Ifjusag u 13, Hungary
    World J Gastroenterol 11:2357-9. 2005
    ..Searching for primary malignancy should include HCC as frequent cause of hypercoagulability. In case of HCC, echocardiography is suggested because of the possibility of expansion in IVC or right atrium and tumor-embolization...
  92. ncbi Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium
    Samuel Sossalla
    Department of Cardiology and Pneumology, Georg August University Gottingen, Gottingen, Germany
    J Am Coll Cardiol 55:2330-42. 2010
    ..We investigated changes in Na(+) currents (I(Na)) in permanent (or chronic) atrial fibrillation (AF) and the effects of I(Na) inhibition using ranolazine (Ran) on arrhythmias and contractility in human atrial myocardium...
  93. ncbi Why, how and when do we need to optimize the setting of cardiac resynchronization therapy?
    Matteo Bertini
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Europace 11:v46-57. 2009
    ..Moreover, an overview of the results of the multicenter trials on AV and VV intervals optimization is provided...
  94. pmc K+ current changes account for the rate dependence of the action potential in the human atrial myocyte
    Mary M Maleckar
    Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Physiol Heart Circ Physiol 297:H1398-410. 2009
    ....
  95. ncbi Patterns of isolated atrial amyloid: a study of 100 hearts on autopsy
    Ivo Steiner
    The Fingerland Department of Pathology, Charles University Faculty of Medicine and Faculty Hospital, 500 05 Hradec Kralove, Czech Republic
    Cardiovasc Pathol 15:287-90. 2006
    ..Hypertension, diabetes mellitus, hypertrophy of the heart, coronary atherosclerosis, and dilatation of the atria show no significant relationship to the incidence or severity of atrial amyloidosis...
  96. ncbi Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit
    James O Tellez
    University of Manchester, Manchester, M13 9NT, UK
    Circ Res 99:1384-93. 2006
    ..For example, Na(v)1.5 messenger RNA is expressed in the SAN periphery (as it is in atrial muscle), but not in the SAN center, and this is probably related to the need of the SAN periphery to drive the surrounding atrial muscle...
  97. ncbi Images in cardiovascular medicine. Spontaneous left atrial dissection and hematoma mimicking a cardiac tumor: findings from echocardiography, cardiac computed tomography, magnetic resonance imaging, and pathology
    Antonella Lombardo
    Cardiology Institute, Catholic University, L go A Gemelli, 8 00168 Rome, Italy
    Circulation 114:e249-50. 2006
  98. ncbi Comparison of Ca2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes
    Pierre Coutu
    Research Center, Montreal Heart Institute, 5000 Belanger St East, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 291:H2290-300. 2006
    ....
  99. ncbi Hydatid cyst of the right atrium: a rare presentation
    Shekhar Tandon
    Department of Cardiothoracic and Vascular Surgery, King George s Medical University, Lucknow, India
    Asian Cardiovasc Thorac Ann 14:e43-4. 2006
    ..The right atrial mass was successfully removed under cardiopulmonary bypass...
  100. ncbi Sodium current function in adult and aged canine atrial cells
    Shigeo Baba
    Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, NY, USA
    Am J Physiol Heart Circ Physiol 291:H756-61. 2006
    ..In conclusion, with age there is no change in I(Na) density, but there are subtle kinetic differences contributing to slight enhancement of use dependence. There is no structural remodeling of the fast Na+ current protein with age...
  101. ncbi Images in cardiovascular medicine. Intramural atrial hematoma after catheter ablation for atrial tachyarrhythmias
    Rajan Sah
    Brigham and Women s Hospital, Cardiovascular Medicine, PBB 1, 75 Francis St, Boston, MA 02115, USA
    Circulation 115:e446-7. 2007

Research Grants62

  1. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    ..We propose to use a new method to treat AF, by inhibiting the function of the nerves that are critical to the genesis of this arrhythmia. By using a new inhibitory protein, we will selectively block these nerves in the left atrium. ..
  2. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2013
    ..However, currently available treatment options for AF are not very effective. We propose a new method to treat AF, by using a novel peptide (protein) to inhibit the function of the nerves that trigger this arrhythmia. ..
  3. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    ..We propose to screen this region of susceptibility in zebrafish, cell lines, and mice for functional elements that may lead to atrial fibrillation. ..
  4. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..S. alone) and, hypothetically, may have a very significant total market potential (estimated at $0.8 to $1.0 billion). ..
  5. Minimally Invasive Surgical Pulmonary Vein Insolation vs. Medical Management in P
    MICHAEL FARRIS WATERS; Fiscal Year: 2010
    ..This application specifically addresses stroke patients with AF by comparing optimal medical therapy with a novel surgical ablative procedure that restores sinus rhythm and ligates the atrial appendage. ..
  6. The mitochondrial calcium uniporter in sinus node physiology and disease
    TYLER PAUL RASMUSSEN; Fiscal Year: 2013
    ..Aim 2: Determine whether MCU inhibition affects physiological HR responses and/or protects against SAN cell death and SND in vivo. ..
  7. CT Method Development for Quantifying Myocardial Microvascular Flow Distribution
    ERIK LEO RITMAN; Fiscal Year: 2013
    ....
  8. C-Arm CT for Guidence of Cardiac Interventions
    Rebecca Fahrig; Fiscal Year: 2010
    ..Access to such images, during an interventional procedure, could also enable new, directed treatments for myocardial infarction by allowing accurate guidance of therapy (cell, drug etc.) directly to the affected tissue. ..
  9. Compliant Thoracic Artificial Lungs
    KEITH ELLIOT COOK; Fiscal Year: 2012
    ..These devices will give chronic lung disease patients more time to find a donor lung and improve their health before and after transplantation. ..
  10. Development of Novel Approaches for the Pharmacologic Treatment of Atrial Fibrill
    Charles Antzelevitch; Fiscal Year: 2013
    ..abstract_text> ..
  11. Low-Dose Tomosynthetic Interventional System For Quantitative Cardiac Imaging
    Michael A Speidel; Fiscal Year: 2013
    ..The successful conclusion of this research will be a low dose x-ray fluoroscopic system which provides clinical image quality, novel therapeutic tools, and 3D imaging capability in a single interventional laboratory. ..
  12. Development of Double Lumen Cannula for Percutaneous Right Heart Support
    Bill Sidor; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: We are proposing to develop a double lumen cannula for percutaneous right ventricular assist device to bridge critical right heart failure patient to recovery, transplantation and advance treatment. ..
  13. Development of Percutaneous DLC for Total Cavo-pulmonary Assistance
    Dongfang Wang; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: We are proposing to develop a percutaneous Cavopulmonary assistance system to bridge the patients with failing Fontan circulation for recovery, reconstructive surgery and heart transplantation. ..
  14. Mechanisms of Pulmonary Vein Development
    Steven B Bleyl; Fiscal Year: 2010
    ..Thus, I will receive the necessary training both to direct an active research program and provide state-of-the-art clinical care. (End of Abstract) ..
  15. 4D Magnetic Resonance Imaging for Atrial Flow Assessment in Atrial Fibrillation
    Jeffrey J Goldberger; Fiscal Year: 2013
    ....
  16. INHIBITORY LEFT ATRIAL INFLUENCES ON THE BAROREFLEX
    David Ramsay; Fiscal Year: 1991
    ..Thus it is anticipated that the essential role of the left atrium in hormonal and thirst responses to simulated hypovolemia will be established and that the mechanism of these interactions will be elucidated...
  17. Late gadolinium enhancement cardiovascular MR for the Detection of Pre-Existent L
    Dana C Peters; Fiscal Year: 2011
    ..This proposal will establish LGE CMR as method for detecting pre- existent fibrosis in AF patients. ..
  18. Paracorporeal Ambulatory Assist Lung
    William R Wagner; Fiscal Year: 2013
    ....
  19. LIGHT STIMULATED CARDIAC PACING AND DEFIBRILLATION
    JULIET MORGAN; Fiscal Year: 1991
    ..Thus, the characterization of the specificities of these Abs will provide new insights into the nature of AD...
  20. Computer Modeling and Cardiac MR of Structural Factors of Atrial Fibrillation
    Jason Ng; Fiscal Year: 2012
    ..This study could have significant implications on the development of individualized strategies for radiofrequency ablation to treat AF. ..
  21. SELECTIVE INNERVATION OF SA & AV NODAL REGIONS OF HEART
    Robert Wurster; Fiscal Year: 1992
    ..Similarly, do extraneuronal interactions from small, intensely fluorescent (SIF) cells exist among these cardiac ganglia, and are they or their interacting neurons, altered by pre- or postganglionic interventions?..
  22. INTRATHORACIC ARTIFICIAL LUNGS
    LYLE MOCKROS; Fiscal Year: 2000
    ..The results of the in-vitro and in-vivo studies will be used to confirm the theoretical models and direct ITAL designs for various etiologies. ..
  23. Compressed Sensing with Motion Models for MRI of Late Gadolinium Enhancement
    EDWARD VR DI BELLA; Fiscal Year: 2012
    ..The development and use of accurate high resolution free-breathing LGE imaging will improve the assessment of myocardial disease and accelerate evaluation of clinical therapies. ..
  24. ELECTROPHYSIOLOGY OF RIGHT ATRIAL PACEMAKERS
    STEPHEN LIPSIUS; Fiscal Year: 2000
    ..This work will contribute to our understanding of atrial brady-tachy dysrhythmias and dysrhythmias initiated by withdrawal of vagal nerve activity. ..
  25. MRI-Guided, Robotically Controlled Cardiac Ablation
    John Pauly; Fiscal Year: 2009
    ..This research also initially targets atrial fibrillation as it is very common (1 in 4 Americans develop it in their lifetime), leads to 1/3 of strokes, and there is a need for a successful method to cure it less invasively. ..
  26. ASSESSMENT OF DIASTOLIC FUNCTION IN HUMANS
    James Thomas; Fiscal Year: 1999
    ....
  27. A minimally invasive cardiac assist device
    Walid Aboulhosn; Fiscal Year: 2004
    ....
  28. MYOCARDIAL CONTROLLED RELEASE IMPLANTS FOR ARRHYTHMIAS
    Robert Levy; Fiscal Year: 2001
    ..3) We will perform comparable therapeutic studies with a candidate RGT plasmid vector, HERG (A561V). ..
  29. BIOELASTIC MATERIAL DEVELOPMENT AS ARTIFICAL PERICARDIA
    BETTY COX; Fiscal Year: 1992
    ..The scarring adhesions result in constrictive pericarditis; and, in 'redo' operations, in severe hemorrhage or the severing previously implanted coronary artery vascular grafts...
  30. ATRIOVENTRICULAR INTERACTIONS RELATED TO CARDIAC SURGERY
    Peter Smith; Fiscal Year: 1992
    ..Left atrial isolation will also be studied in its own right in a colony of animals subjected to this procedure followed by prolonged survival...
  31. CARDIAC VOLUME BY BIPLANE ECHOCARDIOGRAPHY
    Nelson Schiller; Fiscal Year: 1980
    ..D) Detecting subgroups of diabetic heart disease by correlating cardiac volume with diabetic classification...
  32. MECHANISMS OF SYSTOLIC AND DIASTOLIC CARDIAC DEFORMATION
    Edward Shapiro; Fiscal Year: 2001
    ..This may lead to the development of rational new therapies. ..
  33. CA2+-MEDIATED MECHANISMS OF ATRIAL PACEMAKER ACTIVITY
    STEPHEN LIPSIUS; Fiscal Year: 2004
    ..It is expected that the results gained from these studies will provide fundamental insight into the cellular mechanisms governing normal and abnormal atrial pacemaker function. ..
  34. CARDIOVASCULAR PHARMACODYNAMICS IN IMMATURE ANIMALS
    David Driscoll; Fiscal Year: 1980
    ..A refined pulsed ultrasonic Doppler flow probe may be appliable to the measurement of cardiac function following cardiovascular operative procedures in young children...
  35. Endocardial dysfunction in humans with AF
    HUA LINDA CAI; Fiscal Year: 2006
    ..These modalities are anticipated to reduce stroke risk in patients with AF which in turn would markedly reduce modality in the elderly. ..
  36. REGULATORY REFLEXES FROM ISOLATED PULMONARY
    JERRY GREEN; Fiscal Year: 1991
    ..We will also attempt to examine the response of rapidly adapting receptors to CO2 and to quantify their activity as a function of lung volumes below FRC in a manner similar to that reported for these fibers at lung volumes above FRC...
  37. DEVELOPMENT AND TESTING OF A NEW INTRAVENOUS OXYGENATOR
    GARY REEDER; Fiscal Year: 1992
    ....
  38. Cyclin D2 and Cardiac Regeneration
    Loren Field; Fiscal Year: 2007
    ..Ultimately, these experiments will determine if manipulation of the cyclin pathway can be exploited for the induction of therapeutic myocardial growth in the adult heart. ..
  39. Left Atrial Appendage Isolation Device to Reduce Stroke
    Mark Gartner; Fiscal Year: 2004
    ..Among our specific aims in Phase II would be the incorporation of a stapling component so that only one tool would be required to grasp, manipulate, and functionally isolate the LAA. ..
  40. COMPACT, SERVO-REULATED CARDIO-PULMONARY SUPPORT SYSTEM
    THERESE DAVY; Fiscal Year: 1990
    ....
  41. NEUROLOGIC STUDIES IN REQUIRED ECMO
    LEONARD GRAZIANI; Fiscal Year: 1991
    ..Our long range goals are to develop treatment methods that will prevent brain damage in neonatal infants who are susceptible to hypoxemia from severe respiratory failure...
  42. PATHOPHYSIOLOGY OF THE PULMONARY CIRCULATION
    LEON FARHI; Fiscal Year: 1990
    ..Finally, Project 6 concentrates on the effects of injury on the pulmonary endothelium, and provides an anatomical basis for some of the functional studies...
  43. TRANSVASCULAR FLUID AND PROTEIN EXCHANGE IN THE LUNG
    ROBERT ROSELLI; Fiscal Year: 1980
    ..If agreement with experimental data is good the model will be used to predict conditions which may lead to lung edema and, in addition, can be used to predict the rate at which water accumulates in the lungs...
  44. HEMODYNAMIC STUDY OF THE PULMONARY MICROCIRCULATION
    JEN SHIH LEE; Fiscal Year: 1990
    ..We shall study in the third project the density variation induced by the Mueller maneuver aiming to develop an in vivo method to assess the effect of ventilation on the right ventricle, the lung, and the left atrium...
  45. ULTRASONIC EPICARDIAL ABLATION FOR TREATING ATRIAL FIB.
    Richard Bernardi; Fiscal Year: 2003
    ..abstract_text> ..
  46. INTRACAVITARY MAPPING--MODELS AND EXPERIMENTS
    FRANK CLAYDON; Fiscal Year: 1991
    ..The applicant hypothesizes, that intracavitary recordings may be more sensitive to the state of the myocardium and may provide measures with better correlations to physiologic events than epicardial or body surface recordings...
  47. CORONARY COLLATERAL FUNCTION
    DOUGLAS GRIGGS; Fiscal Year: 1991
    ....
  48. DELAYED & ASYMMETRIC VENTRICULAR CONDUCTION MECHANISMS
    John Boineau; Fiscal Year: 1980
    ..These data will lead to greater understanding of the mechanisms and causes of abnormal rhythm and accompanying electrocardiographic patterns. ..
  49. CARDIAC FUNCTION IN HYPERTROPHY
    Alfred Bove; Fiscal Year: 1980
    ..Both studies closely model human disease states, and the data will be immediately applicable to these conditions in man...
  50. Towards a Non-Invasive Therapy for Atrial Fibrillation
    Benjamin Scherlag; Fiscal Year: 2004
    ..This new therapeutic approach could be utilized as a non-invasive application or incorporated into an implantable device for treatment of patients with PAF. ..
  51. Acuson Sequoia Ultrasonograph
    Brian Hoit; Fiscal Year: 2003
    ....
  52. Visualizing the Substrate for Sudden Cardiac Death
    Vivek Reddy; Fiscal Year: 2006
    ..abstract_text> ..
  53. MethLock vs. heparin as dialysis catheter lock
    Stephen Ash; Fiscal Year: 2008
    ..In Phase II we will implement the protocol in a number of dialysis centers and complete the study as originally proposed or as modified after Phase I. ..
  54. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  55. Role of Nonclassical Transmitters in Cardiac Ganglia
    Donald Hoover; Fiscal Year: 2004
    ..abstract_text> ..
  56. Role of VEGF in Neonatal Pulmonary Hypertension
    Theresa Grover; Fiscal Year: 2008
    ..These studies will provide an integrated approach to the hypothesis, incorporating whole animal physiology coupled with molecular and cellular studies. ..
  57. Studies of Atrial Fibrillation in Patients
    Albert Waldo; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  58. The Pathophysiology of T-wave Alternans
    Sanjiv Narayan; Fiscal Year: 2005
    ..This structured approach will ensure the successful completion of this project and, in this way, the development of the applicant into an independent clinician-investigator. ..
  59. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..The safety systems of the existing PF system will be modified to meet the needs of the stand-alone system. Finally, an animal model of sepsis will be used to check efficacy and safety of the entire system. ..
  60. Substrate Mapping & Ablation of Ventricular Tachycardia
    Vivek Reddy; Fiscal Year: 2006
    ..abstract_text> ..