saphenous vein

Summary

Summary: The vein which drains the foot and leg.

Top Publications

  1. ncbi Endoscopic versus open saphenous vein harvest: the effect on postoperative outcomes
    T Z Hayward
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 68:2107-10; discussion 2110-1. 1999
  2. ncbi Towards the treatment of saphenous vein bypass graft failure--a perspective of the Bristol Heart Institute
    Gianni D Angelini
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Biorheology 39:491-9. 2002
  3. ncbi Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from a Department of Veterans Affairs Cooperative Study
    Steven Goldman
    Southern Arizona VA Health Care System and the University of Arizona Sarver Heart Center, Tucson, Arizona, USA
    J Am Coll Cardiol 44:2149-56. 2004
  4. ncbi Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation
    Petra Kleinbongard
    FRCP, Institut fur Pathophysiologie, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Circ Res 108:344-52. 2011
  5. ncbi Off-Pump coronary artery bypass surgery is associated with worse arterial and saphenous vein graft patency and less effective revascularization: Results from the Veterans Affairs Randomized On/Off Bypass (ROOBY) trial
    Brack Hattler
    Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, CO 80220, USA
    Circulation 125:2827-35. 2012
  6. ncbi Causes of varicose vein recurrence: late results of a randomized controlled trial of stripping the long saphenous vein
    Rebecca J Winterborn
    Department of Vascular Surgery, Gloucestershire Royal Hospital, United Kingdom
    J Vasc Surg 40:634-9. 2004
  7. pmc Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein
    R S Mughal
    Division of Cardiovascular and Neuronal Remodelling, University of Leeds, Worsley Building, Leeds LS2 9JT, UK
    Diabetologia 53:1761-71. 2010
  8. ncbi Treatment of the incompetent great saphenous vein by endovenous radiofrequency powered segmental thermal ablation: first clinical experience
    Thomas Michael Proebstle
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    J Vasc Surg 47:151-156. 2008
  9. ncbi Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy
    Sarah J George
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Circulation 124:S135-42. 2011
  10. pmc Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells
    Jing Li
    Multidisciplinary Cardiovascular Research Centre, Faculty of Biological Sciences, University of Leeds, United Kingdom
    Circ Res 103:e97-104. 2008

Detail Information

Publications259 found, 100 shown here

  1. ncbi Endoscopic versus open saphenous vein harvest: the effect on postoperative outcomes
    T Z Hayward
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 68:2107-10; discussion 2110-1. 1999
    ..The purpose of this study was to objectively compare the two techniques...
  2. ncbi Towards the treatment of saphenous vein bypass graft failure--a perspective of the Bristol Heart Institute
    Gianni D Angelini
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Biorheology 39:491-9. 2002
    ..The objective of this article, therefore, is to review these recent approaches and their potential clinical applications in the treatment of vein graft disease...
  3. ncbi Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from a Department of Veterans Affairs Cooperative Study
    Steven Goldman
    Southern Arizona VA Health Care System and the University of Arizona Sarver Heart Center, Tucson, Arizona, USA
    J Am Coll Cardiol 44:2149-56. 2004
    This study defined long-term patency of saphenous vein grafts (SVG) and internal mammary artery (IMA) grafts.
  4. ncbi Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation
    Petra Kleinbongard
    FRCP, Institut fur Pathophysiologie, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Circ Res 108:344-52. 2011
    ..Stent implantation into atherosclerotic plaques releases, apart from particulate debris, soluble substances that contribute to impaired microvascular perfusion...
  5. ncbi Off-Pump coronary artery bypass surgery is associated with worse arterial and saphenous vein graft patency and less effective revascularization: Results from the Veterans Affairs Randomized On/Off Bypass (ROOBY) trial
    Brack Hattler
    Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, CO 80220, USA
    Circulation 125:2827-35. 2012
    ....
  6. ncbi Causes of varicose vein recurrence: late results of a randomized controlled trial of stripping the long saphenous vein
    Rebecca J Winterborn
    Department of Vascular Surgery, Gloucestershire Royal Hospital, United Kingdom
    J Vasc Surg 40:634-9. 2004
    The purpose of this study was to investigate the long-term outcomes following stripping of the long saphenous vein during primary varicose vein surgery and to identify factors which may predict recurrence and the need for reoperation.
  7. pmc Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein
    R S Mughal
    Division of Cardiovascular and Neuronal Remodelling, University of Leeds, Worsley Building, Leeds LS2 9JT, UK
    Diabetologia 53:1761-71. 2010
    ..cells (ECs) and smooth muscle cells (SMCs) play key roles in the development of intimal hyperplasia in saphenous vein (SV) bypass grafts...
  8. ncbi Treatment of the incompetent great saphenous vein by endovenous radiofrequency powered segmental thermal ablation: first clinical experience
    Thomas Michael Proebstle
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    J Vasc Surg 47:151-156. 2008
    ..This article reports a new endovenous catheter for radiofrequency-powered segmental thermal ablation (RSTA) of incompetent great saphenous veins (GSVs)...
  9. ncbi Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy
    Sarah J George
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Circulation 124:S135-42. 2011
    ..However, it is essential to determine whether this approach will provide longer-term benefits...
  10. pmc Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells
    Jing Li
    Multidisciplinary Cardiovascular Research Centre, Faculty of Biological Sciences, University of Leeds, United Kingdom
    Circ Res 103:e97-104. 2008
    ....
  11. ncbi Randomized trial of a distal embolic protection device during percutaneous intervention of saphenous vein aorto-coronary bypass grafts
    Donald S Baim
    Division of Cardiovascular Diseases, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 105:1285-90. 2002
    ..We report the first multicenter randomized trial to evaluate use of a distal embolic protection device during stenting of such lesions...
  12. ncbi Selective gene silencing of either MMP-2 or MMP-9 inhibits invasion of human saphenous vein smooth muscle cells
    Neil A Turner
    Institute for Cardiovascular Research, School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Atherosclerosis 193:36-43. 2007
    ..facilitates smooth muscle cell (SMC) invasion, an important event in the development of intimal hyperplasia in saphenous vein (SV) bypass grafts...
  13. ncbi Combined use of aspiration catheter and distal embolisation protection device to facilitate angioplasty of a totally occluded saphenous vein graft
    Michalis I Hamilos
    Cardiology Department, University Hospital of Heraklion, Crete, Greece
    Hellenic J Cardiol 48:117-21. 2007
    Angioplasty of totally occluded saphenous vein grafts is a very challenging procedure and the likelihood of distal embolisation and no-reflow is much higher than in any conventional angioplasty...
  14. ncbi Extension of saphenous thrombus into the femoral vein: a potential complication of new endovenous ablation techniques
    Geza Mozes
    Division of Vascular Surgery, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    J Vasc Surg 41:130-5. 2005
    ..3% after ELT and 2.1% after RFA. This possibility warrants routine postoperative duplex scanning, more alertness during these procedures, and patient education on this possible complication...
  15. ncbi Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels
    Neil A Turner
    Institute for Cardiovascular Research, University of Leeds, Leeds, UK
    FASEB J 19:804-6. 2005
    Increased matrix metalloproteinase-9 (MMP-9) expression is associated with intimal hyperplasia in saphenous vein (SV) bypass grafts...
  16. ncbi Carbon dioxide embolism induced by endoscopic saphenous vein harvesting during coronary artery bypass grafting
    Arnaud Mommerot
    J Thorac Cardiovasc Surg 132:1502; author reply 1502-3. 2006
  17. ncbi Evaluation of the efficacy of polidocanol in the form of foam compared with liquid form in sclerotherapy of the greater saphenous vein: initial results
    Claudine Hamel-Desnos
    Center Hospitalier Privé Saint Martin, 18 Rue des Rocquemonts, 14050 Caen Cedex, France
    Dermatol Surg 29:1170-5; discussion 1175. 2003
    ..Until now, however, no comparative study for the treatment of large varicose veins with foam or liquid exists...
  18. ncbi One-year survival in patients with acute myocardial infarction and a saphenous vein graft culprit treated with primary angioplasty
    Thanh T Nguyen
    William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Cardiol 91:1250-4. 2003
  19. ncbi Surgical management of varicose veins: meta-analysis
    Ranjeet Brar
    St George s Vascular Institute, St George s Hospital, London, UK
    Vascular 18:205-20. 2010
    ..24 days; 95% CI 10.50-5.97) or EVLT (by 5.02 days; 95% CI 6.52-3.52). Endovascular treatment of varicose veins is safe and effective and offers the significant advantage of rapid recovery...
  20. ncbi Radiofrequency endovenous obliteration versus stripping of the long saphenous vein in the management of primary varicose veins: 3-year outcome of a randomized study
    Jukka Perälä
    Department of Radiology, Oulu University Hospital, Oulu, Finland
    Ann Vasc Surg 19:669-72. 2005
    ..stripping of the long saphenous vein (LSV)...
  21. ncbi Pathophysiology of aortocoronary saphenous vein bypass graft disease
    Seyed Ahmad Hassantash
    Department of Cardiovascular Surgery, Modarres Medical Center, Shaheed Beheshti University of Medical Sciences, Saadat Abad, Tehran, Iran
    Asian Cardiovasc Thorac Ann 16:331-6. 2008
    Aortocoronary saphenous vein bypass grafting relieves anginal pain in patients with coronary artery disease. However, its effectiveness is limited due to graft failure; the 10-year patency rate is 50%-60%...
  22. ncbi Outcomes and side effects of duplex-guided sclerotherapy in the treatment of great saphenous veins with 1% versus 3% polidocanol foam: results of a randomized controlled trial with 1-year follow-up
    Roeland P M Ceulen
    Department of Dermatology, University Hospital Maastricht, Maastricht, The Netherlands
    Dermatol Surg 33:276-81. 2007
    ..Eighty subjects were treated with either 1 or 3% polidocanol foam to compare the efficacy and adverse sequelae of each concentration of polidocanol foam...
  23. ncbi Prospective, randomized evaluation of thrombectomy prior to percutaneous intervention in diseased saphenous vein grafts and thrombus-containing coronary arteries
    Gregg W Stone
    Cardiovascular Research Foundation and Lenox Hill Hospital, New York, New York 10022, USA
    J Am Coll Cardiol 42:2007-13. 2003
    We sought to determine whether routine thrombectomy prior to stent implantation in diseased saphenous vein grafts (SVGs) and thrombus-containing native coronary arteries would reduce peri-procedural myonecrosis and subsequently enhance ..
  24. ncbi Great saphenous vein radiofrequency ablation versus standard stripping in the management of primary varicose veins-a randomized clinical trial
    Khaled Helmy ElKaffas
    Department of Radiodiagnosis, Cairo University, Egypt
    Angiology 62:49-54. 2011
    ..Chronic venous insufficiency is the most common vascular disease in the adult population. However, randomized clinical trials (RCTs) comparing therapeutic options are limited...
  25. ncbi Three-year European follow-up of endovenous radiofrequency-powered segmental thermal ablation of the great saphenous vein with or without treatment of calf varicosities
    Thomas M Proebstle
    Department of Dermatology, University of Mainz, Mainz, Germany
    J Vasc Surg 54:146-52. 2011
    ..Radiofrequency segmental thermal ablation (RSTA) has become a commonly used technology for occlusion of incompetent great saphenous veins (GSVs). Midterm results and data on clinical parameters are still lacking...
  26. ncbi Anti-angiogenic activity of human endostatin is HIF-1-independent in vitro and sensitive to timing of treatment in a human saphenous vein assay
    Gordon R Macpherson
    Molecular Pharmacology Laboratory, Laboratory of Receptor Biology and Gene Expression, and Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cancer Ther 2:845-54. 2003
    ..Importantly, inhibition of vessel outgrowth by Calbiochem endostatin in a human saphenous vein angiogenesis assay required early treatment...
  27. ncbi Transesophageal echocardiographic diagnosis of carbon dioxide embolism during minimally invasive saphenous vein harvesting and treatment with inhaled epoprostenol
    Andre Martineau
    Department of Anesthesiology, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, H1T 1C8 Canada
    Anesth Analg 96:962-4, table of contents. 2003
    ..Transesophageal echocardiography was useful in the diagnosis of CO2 embolism and to assess response to inhaled epoprostenol...
  28. ncbi Initial experiences in endovenous treatment of saphenous vein reflux
    Johannes E M Sybrandy
    Department of Vascular Surgery, Sint Franciscus Hospital, Kleiweg 500, 3045 PM Rotterdam, The Netherlands
    J Vasc Surg 36:1207-12. 2002
    The most common site of venous reflux is the long saphenous vein (LSV). The preferred treatment for reflux in the LSV is surgical stripping of the LSV. However, the complications of surgical stripping are well documented and undesirable...
  29. ncbi Treatment of recurrent varicose veins of the great saphenous vein by conventional surgery and endovenous laser ablation
    Laura van Groenendael
    Department of Surgery, Division of Vascular Surgery, Alysis Zorggroep, Location Rijnstate, Arnhem, The Netherlands
    J Vasc Surg 50:1106-13. 2009
    Varicose vein recurrence of the great saphenous vein (GSV) is a common, costly, and complex problem...
  30. ncbi Angiographic predictors of 3-year patency of bypass grafts implanted on the right coronary artery system: a prospective randomized comparison of gastroepiploic artery, saphenous vein, and right internal thoracic artery grafts
    David Glineur
    Department of Cardiovascular Medicine and Surgery, Cliniques Universitaire St Luc, Brussels, Belgium
    J Thorac Cardiovasc Surg 142:980-8. 2011
    b>Saphenous vein, in situ right gastroepiploic artery, and right internal thoracic artery grafts are routinely used to revascularize the right coronary artery...
  31. ncbi Endoscopic vs open saphenous vein harvest for coronary artery bypass grafting: a prospective randomized trial
    Jan Jesper Andreasen
    Department of Cardiothoracic Surgery, Aalborg Hospital, University of Aarhus, Hobrovej, Aalborg, Denmark
    Eur J Cardiothorac Surg 34:384-9. 2008
    Endoscopic saphenous vein harvesting (EVH) for coronary artery bypass grafting (CABG) has been developed to reduce leg wound morbidity and improve patient satisfaction...
  32. ncbi Endothelin-1 and vein graft occlusion in patients undergoing bypass surgery
    M R Dashwood
    Royal Free and University College Medical School, London, UK
    Eur J Clin Invest 39:78-87. 2009
    The saphenous vein is the most commonly used graft for revascularization procedures in patients with coronary artery disease and critical limb ischaemia...
  33. ncbi Endoscopic greater saphenous vein harvesting reduces the morbidity of coronary artery bypass surgery
    Chance D Felisky
    Department of Surgery, Section of Cardiothoracic Surgery, Virginia Mason Medical Center, 1201 Terry Ave, Seattle, WA 98101, USA
    Am J Surg 183:576-9. 2002
    Most coronary artery bypass grafting (CABG) operations still involve the use of greater saphenous vein (GSV) for one or more grafts, even with the increasing use of arterial conduits for coronary revascularization...
  34. ncbi Endoscopic saphenous vein harvesting for CABG -- a randomized, prospective trial
    U P Schurr
    Clinic of Cardiovascular Surgery, University Hospital, Zurich, Switzerland
    Thorac Cardiovasc Surg 50:160-3. 2002
    The saphenous vein is an established conduit for coronary revascularization. Disadvantages of traditional harvest technique are significant pain and morbidity. We compared the endoscopic harvest technique with the traditional method.
  35. ncbi Early quantitative coronary angiography of saphenous vein grafts for coronary artery bypass grafting harvested by means of open versus endoscopic saphenectomy: a prospective randomized trial
    L P Perrault
    Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 127:1402-7. 2004
    ..Concern remains about the patency of saphenous vein grafts harvested endoscopically and the development of early intimal hyperplasia...
  36. ncbi Endoscopic vein harvest: advantages and limitations
    Pramod Bonde
    Department of Cardiac Surgery, Royal Victoria Hospital, Belfast, United Kingdom
    Ann Thorac Surg 77:2076-82. 2004
    Although long saphenous vein remains the most commonly used conduit in coronary revascularization, traditional open vein harvest (OVH) may lead to significantly impaired wound healing and postoperative pain...
  37. ncbi Saphenous vein loop to femoral artery arteriovenous fistula: a practical alternative
    Daphne Pierre-Paul
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Ann Vasc Surg 18:223-7. 2004
    ..The authors' experience with the greater saphenous vein to common femoral artery loop arteriovenous fistula (GSV-CFA AVF) is presented...
  38. ncbi Current neurosurgical indications for saphenous vein graft bypass
    Jonathan A Friedman
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurg Focus 14:e1. 2003
    ..Creation of an interposition saphenous vein graft (SVG) is the typical method of choice when the superficial temporal artery is not an option.
  39. ncbi Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration
    Karen E Porter
    Integrated Molecular Cardiology Group, Institute for Cardiovascular Research, University of Leeds, United Kingdom
    J Vasc Surg 36:150-7. 2002
    Migration and proliferation of vascular smooth muscle cells (SMCs) contributes to intimal hyperplasia in saphenous vein (SV) bypass grafts, which leads to patency-threatening stenosis...
  40. ncbi Randomized comparison of distal protection with a filter-based catheter and a balloon occlusion and aspiration system during percutaneous intervention of diseased saphenous vein aorto-coronary bypass grafts
    Gregg W Stone
    Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, 55 E 59th St, 6th Floor, New York, NY 10022, USA
    Circulation 108:548-53. 2003
    ..complications resulting from atherothrombotic embolization after percutaneous intervention in diseased saphenous vein grafts is reduced by distal microcirculatory protection using a balloon occlusion and aspiration system...
  41. ncbi Impact of endoscopic versus open saphenous vein harvest technique on late coronary artery bypass grafting patient outcomes in the ROOBY (Randomized On/Off Bypass) Trial
    Marco A Zenati
    Veterans Affairs Boston Healthcare System, West Roxbury, MA 02132, USA
    J Thorac Cardiovasc Surg 141:338-44. 2011
    ..This ROOBY Trial planned subanalysis compared the effects on postbypass patient clinical outcomes and graft patency of endoscopic vein harvesting and open vein harvesting...
  42. ncbi Comparison of saphenous vein and internal thoracic artery graft patency by coronary system
    Joseph F Sabik
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 79:544-51; discussion 544-51. 2005
    We sought to compare saphenous vein and internal thoracic artery graft patency by coronary system.
  43. ncbi Potential cell sources for tissue engineering of heart valves in comparison with human pulmonary valve cells
    Philipp K Schaefermeier
    Department of Cardiac Surgery, Laboratory for Tissue Engineering and Cell Transplantation, University Hospital of the Ludwig Maximilians University, Munich, Germany
    ASAIO J 55:86-92. 2009
    ..We inspected morphological and marker gene expression differences between cells harvested from the saphenous vein, or from veins and arteries of the umbilical cord, and the cells they are designed to replace: the ..
  44. ncbi Harvesting the saphenous vein with surrounding tissue for CABG provides long-term graft patency comparable to the left internal thoracic artery: results of a randomized longitudinal trial
    Domingos S R Souza
    Department of Cardiothoracic Surgery and Anesthesiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
    J Thorac Cardiovasc Surg 132:373-8. 2006
    Conventional harvesting of the saphenous vein in coronary artery bypass surgery produces vessel damage that contributes to graft failure. A novel "no touch" technique provides high short- and long-term patency rates.
  45. ncbi Radial artery versus saphenous vein patency randomized trial: five-year angiographic follow-up
    Peter Collins
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Circulation 117:2859-64. 2008
    ..Left and right internal thoracic artery (arterial) graft patency has been shown to be superior to that of saphenous vein grafts...
  46. ncbi Diabetes modulates capacitative calcium entry and expression of transient receptor potential canonical channels in human saphenous vein
    Ada W Y Chung
    The James Hogg iCAPTURE Center for the Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia, Canada
    Eur J Pharmacol 613:114-8. 2009
    ..In saphenous vein samples (n=20) collected from diabetic patients undergoing bypass surgery, the contraction initiated by the ..
  47. ncbi Randomized trial of endoscopic versus open vein harvest for coronary artery bypass grafting: six-month patency rates
    Kwok L Yun
    Department of Cardiac Surgery, Kaiser Permanente Medical Center, Los Angeles, Calif, USA
    J Thorac Cardiovasc Surg 129:496-503. 2005
    ..We sought to compare the 6-month angiographic patency rates of greater saphenous veins removed during coronary artery bypass grafting with the endoscopic vein harvest or open vein harvest techniques...
  48. ncbi A prospective randomized trial of endoscopic versus conventional harvesting of the saphenous vein in coronary artery bypass surgery
    Bob Kiaii
    Department of Surgery, University of Western Ontario, London, Ontario, Canada
    J Thorac Cardiovasc Surg 123:204-12. 2002
    Our objectives were (1) to determine whether minimally invasive endoscopic harvesting of the saphenous vein reduces morbidity due to postoperative wound infection and pain with improved cosmetic results and mobilization as compared with ..
  49. ncbi Leg wound infection after coronary artery bypass grafting: a meta-analysis comparing minimally invasive versus conventional vein harvesting
    Thanos Athanasiou
    The National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Department of Cardiothoracic Surgery, St Mary s Hospital, London, United Kingdom
    Ann Thorac Surg 76:2141-6. 2003
    The great saphenous vein remains the most commonly harvested conduit for revascularization in coronary artery bypass grafting (CABG)...
  50. ncbi Endothelial function impairment in chronic venous insufficiency: effect of some cardiovascular protectant agents
    Omar F Carrasco
    Department of Pharmacology, School of Medicine, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Angiology 60:763-71. 2009
    ....
  51. ncbi External carotid artery to middle cerebral artery bypass with the saphenous vein graft
    Erica F Bisson
    Division of Neurosurgery, Department of Surgery, University of Vermont College of Medicine, Burlington, Vermont, USA
    Neurosurgery 62:134-8; discussion 138-9. 2008
    ..It is in these patients that use of the saphenous vein should be considered...
  52. ncbi Patency rate of the internal thoracic artery to the left anterior descending artery bypass is reduced by competitive flow from the concomitant saphenous vein graft in the left coronary artery
    Masashi Kawamura
    Department of Cardiovascular Surgery, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Eur J Cardiothorac Surg 34:833-8. 2008
    ..A patent saphenous vein (SV) graft from the ascending aorta can reduce the blood flow through the ITA graft, and may affect its long-..
  53. ncbi Early and late outcome after carotid artery bypass grafting with saphenous vein
    C Lauder
    Department of Vascular Surgery, Leicester Royal Infirmary, England
    J Vasc Surg 38:1025-30. 2003
    This study was undertaken to determine outcome and durability of internal carotid artery bypass grafting with saphenous vein.
  54. ncbi Intermittent short saphenous vein phlebotomy: an effective technique of relieving venous congestion in the distally based sural artery flap
    Chin Ho Wong
    Department of Plastic, Reconstructive and Aesthetic Surgery, Singapore General Hospital, Singapore
    Ann Plast Surg 58:303-7. 2007
    ..Herein, we present our technique of phlebotomy to relieve flap congestion. Venous blood is intermittently drained via an exteriorized segment of the short saphenous vein until flap circulation normalizes.
  55. ncbi Ultrasound changes at the saphenofemoral junction and in the long saphenous vein during the first year after VNUS closure
    N Fassiadis
    Department of Vascular Surgery, Royal Surrey County Hospital, Guildford, UK
    Int Angiol 21:272-4. 2002
    ..percutaneous catheter-based device using a radiofrequency current to cause permanent closure of the long saphenous vein (LSV) as an alternative to high tie and stripping...
  56. ncbi Endovenous mechanochemical ablation of great saphenous vein incompetence using the ClariVein device: a safety study
    Ramon R J P van Eekeren
    Department of Surgery, Rijnstate Hospital, Arnhem, The Netherlands
    J Endovasc Ther 18:328-34. 2011
    To evaluate the feasibility and safety of endovenous mechanochemical ablation (MOCA) for the treatment of great saphenous vein (GSV) incompetence.
  57. pmc Evaluation of endoscopic vein extraction on structural and functional viability of saphenous vein endothelium
    Bader E Hussaini
    Cardiothoracic Surgery Division, Veterans Affairs Boston Healthcare System, Boston, MA, USA
    J Cardiothorac Surg 6:82. 2011
    ..We have previously shown that endoscopic harvest causes structural and functional damage to the saphenous vein (SV) endothelium. However, causes of such injury may depend on the extraction technique...
  58. ncbi Acute vasomotor paralysis and potential downstream effects of paclitaxel from stents implanted for saphenous vein aorto-coronary bypass stenosis
    Petra Kleinbongard
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Hufelandstrasse 55, Essen, Germany
    Basic Res Cardiol 106:681-9. 2011
    ..stent [n = 14 BMS, n = 14 PES, n = 3 sirolimus eluting stents (SES)] implantation in patients with saphenous vein aorto-coronary bypass stenosis and analyzed for plasma serotonin and thromboxane B(2) concentrations...
  59. ncbi Saphenous ablation: what are the choices, laser or RF energy
    Nick Morrison
    Morrison Vein Institute, Scottsdale, AZ 85258, USA
    Semin Vasc Surg 18:15-8. 2005
    Endovenous ablation has been reported to be safe and effective in eliminating the proximal portion of the great saphenous vein from the venous circulation, with faster recovery and better cosmetic results than surgical stripping...
  60. ncbi Even short-time storage in physiological saline solution impairs endothelial vascular function of saphenous vein grafts
    Manuel Wilbring
    Department for Cardiac Surgery, University Heart Center Dresden, Dresden, Germany
    Eur J Cardiothorac Surg 40:811-5. 2011
    ..Storage solutions for intra-operatively harvested saphenous vein segments (SVS) might have significant impact on endothelial function...
  61. ncbi The immediate effects of endovenous diode 808-nm laser in the greater saphenous vein: morphologic study and clinical implications
    Leonardo Corcos
    Postgraduate School of Vascular Surgery, University of Udine, Italy
    J Vasc Surg 41:1018-24; discussion 1025. 2005
    ....
  62. ncbi Endovenous radiofrequency ablation of saphenous vein reflux. The VNUS Closure procedure with Closurefast. An updated review
    M Perrin
    Clinique du Grand Large, Decines Charpieu, France FR
    Int Angiol 29:303-7. 2010
    ..Procedure is shortened and short-term results are better than those provided by the previous Closure catheter. A randomized control trial ClosureFAST versus endovenous laser is in favour of the first one...
  63. ncbi Influence of gender on early and one-year clinical outcomes after saphenous vein graft stenting
    J M Ahmed
    Cardiovascular Research Foundation, New York, New York 10022, USA
    Am J Cardiol 87:401-5. 2001
    ..However, the influence of gender on clinical outcomes after saphenous vein graft (SVG) stenting is unknown...
  64. ncbi Reduction of carbon dioxide embolism for endoscopic saphenous vein harvesting
    Kuan Ming Chiu
    Department of Cardiovascular Surgery, Far Eastern Memorial Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Ann Thorac Surg 81:1697-9. 2006
    The endoscopic saphenous vein harvesting (EVH) introduced in coronary artery bypass surgery (CABG) is associated with less wound complication and postoperative pain...
  65. ncbi Are we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results
    M K Hong
    Department of Internal Medicine, Cornell University New York Presbyterian Hospital, New York 10021, USA
    J Am Coll Cardiol 38:150-4. 2001
    We sought to determine whether strategies to reduce procedural distal embolization and late repeat revascularization have resulted in more favorable outcomes after saphenous vein graft (SVG) angioplasty.
  66. ncbi Endoscopic versus open saphenous vein harvest for femoral to below the knee arterial bypass using saphenous vein graft
    Leo M Gazoni
    Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Vasc Surg 44:282-7; discussion 287-8. 2006
    ..We hypothesized that EVH improves outcomes compared with open vein harvest (OVH) in patients undergoing femoral to below the knee arterial bypass surgery...
  67. ncbi Pivotal, randomized U.S. study of the Symbiottrade mark covered stent system in patients with saphenous vein graft disease: eight-month angiographic and clinical results from the Symbiot III trial
    Mark A Turco
    Center for Cardiac and Vascular Research, Washington Adventist Hospital, Takoma Park, Maryland 20912, USA
    Catheter Cardiovasc Interv 68:379-88. 2006
    The purpose of this study was to evaluate the clinical and angiographic outcomes of the Symbiot ePTFE covered stent versus bare metal stents (BMS) for the treatment of saphenous vein graft (SVG) disease.
  68. ncbi Clinical characteristics associated with poor long-term survival among patients with diabetes mellitus undergoing saphenous vein graft interventions
    Rajendra H Mehta
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 156:728-35. 2008
    Limited data exist on the long-term outcomes among diabetic patients undergoing saphenous vein graft (SVG) interventions. Thus, the baseline clinical factors associated with long-term adverse events in these patients are less known.
  69. ncbi Late outcomes after radial artery versus saphenous vein grafting during reoperative coronary artery bypass surgery
    Anoar Zacharias
    Yvonne Viens, SGM, Research Institute Saint Vincent Mercy Medical Center, Toledo, Ohio 43608, USA
    J Thorac Cardiovasc Surg 139:1511-1518.e4. 2010
    We investigated whether use of radial artery versus saphenous vein grafts during coronary artery bypass grafting reoperations is associated with a significant long-term survival benefit.
  70. ncbi Has the in situ right internal thoracic artery been overlooked? An angiographic study of the radial artery, internal thoracic arteries and saphenous vein graft patencies in symptomatic patients
    Pallav J Shah
    Department of Cardiac Surgery, Austin Hospital, Melbourne, Vic, Australia
    Eur J Cardiothorac Surg 27:870-5. 2005
    ..Conversely, the radial artery utilization has increased with only limited data available. The purpose of this paper is to re-evaluate the roles of the right internal thoracic artery and the radial artery grafts...
  71. ncbi Acute and mid-term local vascular effects of compliant balloon inflation (GuardWire system) on saphenous vein bypass grafts: an angiographic analysis
    Pierfrancesco Agostoni
    Antwerp Cardiovascular Institute Middelheim, AZ Middelheim, Lindendreef 1, 2020 Antwerp, Belgium
    Int J Cardiol 120:227-31. 2007
    ..device reduces the incidence of periprocedural complications during percutaneous stenting of diseased saphenous vein grafts...
  72. ncbi Hemodynamic evaluation of saphenous vein coronary artery bypass grafts: relative merits of Doppler flow velocity and SPECT perfusion imaging
    Liesbeth P Salm
    Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Nucl Cardiol 12:545-52. 2005
    ..In this study hemodynamic consequences of significant stenoses in vein grafts were evaluated by Doppler velocity assessment, and results were compared with single photon emission computed tomography (SPECT) perfusion imaging...
  73. ncbi Prothrombotic gene expression profile in vascular smooth muscle cells of human saphenous vein, but not internal mammary artery
    S K Payeli
    Cardiovascular Research, Physiology Institute, University of Zurich, Switzerland
    Arterioscler Thromb Vasc Biol 28:705-10. 2008
    ..This study analyzed gene expression profiles of vascular smooth muscle cells (VSMCs) from IMA versus saphenous vein (SV).
  74. ncbi Enhanced nitric oxide-mediated vascular relaxation in radial artery compared with internal mammary artery or saphenous vein
    O M Shapira
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston, MA, USA
    Circulation 100:II322-7. 1999
    ..The purpose of this study was to compare the.NO-mediated vasomotor properties of the radial artery to those of the internal mammary artery and saphenous vein.
  75. pmc Pharmacological studies on prostanoid receptors in the rabbit isolated saphenous vein: a comparison with the rabbit isolated ear artery
    S J Lydford
    Department of Pharmacology, Astra Charnwood, Loughborough, Leicestershire
    Br J Pharmacol 117:13-20. 1996
    1. In isolated ring preparations of the rabbit saphenous vein, prostaglandin E2 (PGE2) caused well-defined, stable and concentration-dependent relaxations of KCl contracted tissues with a mean potency (p[A50]) of 9.39. 2...
  76. ncbi Reduction in wound morbidity rates following endoscopic saphenous vein harvest
    K A Illig
    Division of Vascular Surgery, University of Rochester Medical Center, NY 14642, USA
    Ann Vasc Surg 15:104-9. 2001
    To determine whether less-invasive saphenous vein harvest reduces morbidity in patients undergoing infrainguinal bypass, we retrospectively compared 61 patients undergoing endoscopic harvest (ENDO) with 49 patients undergoing conventional ..
  77. ncbi Long saphenous vein stripping and quality of life--a randomised trial
    M T Durkin
    Department of Vascular and Endovascular Surgery, St James's University Hospital, Leeds Teaching Hospitals Trust, Leeds, UK
    Eur J Vasc Endovasc Surg 21:545-9. 2001
    ..To assess the quality of life of patients undergoing sapheno-femoral junction (SFJ) ligation and long saphenous vein stripping (LSV), using two different techniques. DESIGN: Prospective, randomised trial...
  78. ncbi Sparing of saphenous vein during inguinal lymphadenectomy for vulval malignancies
    Xiaoling Zhang
    Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Jinan, 250117, Shandong, PR China
    Gynecol Oncol 105:722-6. 2007
    This work was set out to investigate the effect of saphenous vein preservation during inguinal lymphadenectomy for patients with vulval malignancies.
  79. ncbi Inadvertent dilation of a saphenous vein graft stenosis by the PercuSurge GuardWire distal protection balloon
    Naveen Sharma
    Krannert Institute of Cardiology, Clarian Cardiovascular Center, Department of Medicine, Indiana University, Indianapolis, Indiana, USA
    Catheter Cardiovasc Interv 59:346-9. 2003
    ..a moderate distal stenosis at the site of GuardWire balloon inflation while intervening on a critical proximal saphenous vein graft stenosis...
  80. ncbi Patient characteristics and physician-determined variables affecting saphenofemoral reflux recurrence after ligation and stripping of the great saphenous vein
    Reinhard Fischer
    Center for Vascular Diseases, St Gallen, Switzerland
    J Vasc Surg 43:81-87. 2006
    ..To identify patient and physician-controlled treatment variables that might predict the persistence or redevelopment of saphenofemoral junction (SFJ) reflux...
  81. ncbi Manual aspiration prior to stenting does not reduce the incidence of filter no reflow in saphenous vein graft lesions protected by FilterWire EX/EZ
    Man Hong Jim
    Cardiac Medical Unit, Grantham Hospital, Hong Kong
    Acute Card Care 12:92-5. 2010
    The beneficial role of manual thrombus aspiration in thrombus-containing lesions has been proven in acute myocardial infarction but data is lacking in saphenous vein graft lesions.
  82. ncbi Disease progression in nonintervened saphenous vein graft segments a serial intravascular ultrasound analysis
    Young Joon Hong
    Cardiovascular Research Institute Medstar Research Institute, Washington Hospital Center, DC 20010, USA
    J Am Coll Cardiol 53:1257-64. 2009
    We used serial intravascular ultrasound (IVUS) to assess disease progression in nonintervened saphenous vein graft (SVG) segments to determine the natural rate of disease progression in SVG.
  83. ncbi Evaluation of culprit saphenous vein graft lesions with optical coherence tomography in patients with acute coronary syndromes
    Periklis Davlouros
    Department of Cardiology, Patras University Hospital, Patras, Greece
    JACC Cardiovasc Interv 4:683-93. 2011
    This study sought to assess, with optical coherence tomography (OCT), presumably culprit atherosclerotic lesions of saphenous vein grafts (SVGs) in patients with acute coronary syndromes (ACS).
  84. ncbi Does periadventitial fat-derived nitric oxide play a role in improved saphenous vein graft patency in patients undergoing coronary artery bypass surgery?
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, UK
    J Vasc Res 44:175-81. 2007
    The saphenous vein is commonly used for coronary artery bypass surgery but its patency is poor. Vascular damage occurs during conventional surgery...
  85. ncbi Immunocytochemical study on endothelial integrity of saphenous vein grafts harvested by minimally invasive surgery with the use of vascular mayo stripers. A randomized controlled trial
    M Nowicki
    Department of Histology and Embryology, Karol Marcinkowski University of Medical Sciences, ul Swiecickiego 6, 60 781 Poznan, Poland
    Eur J Vasc Endovasc Surg 27:244-50. 2004
    The aim of this study is to compare the endothelial integrity of saphenous vein grafts harvested by minimally invasive surgery and veins harvested conventionally for coronary artery bypass surgery in 200 participants who were assigned to ..
  86. ncbi Occlusive wrap dressing reduces infection rate in saphenous vein harvest site
    Franklin L Rosenfeldt
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Victoria, Australia
    Ann Thorac Surg 75:101-5; discussion 105. 2003
    Infection in the saphenous vein harvest site is a common problem. We developed an occlusive circumferential wrap dressing technique that reduces skin edge tension, eliminates dead space, and prevents external contamination...
  87. ncbi 5-year follow-up of polytetrafluoroethylene-covered stents compared with bare-metal stents in aortocoronary saphenous vein grafts the randomized BARRICADE (barrier approach to restenosis: restrict intima to curtail adverse events) trial
    Gregg W Stone
    Department of Medicine, Division of Cardiology, Columbia University, Medical Center New York Presbyterian Hospital, Cardiovascular Research Foundation, New York 10022, USA
    JACC Cardiovasc Interv 4:300-9. 2011
    We sought to evaluate the utility of the JOSTENT polytetrafluoroethylene (PTFE) stent-graft (Jomed GmbH, Rangendingen, Germany) in patients with diseased saphenous vein grafts (SVGs) undergoing percutaneous coronary intervention (PCI).
  88. ncbi Neovascularisation and recurrence 2 years after varicose vein treatment for sapheno-femoral and great saphenous vein reflux: a comparison of surgery and endovenous laser ablation
    N S Theivacumar
    The Leeds Vascular Institute, General Infirmary at Leeds, Leeds LS1 3EX, UK
    Eur J Vasc Endovasc Surg 38:203-7. 2009
    ..This prospective cohort study compares recurrence rates and the occurrence of neovascularisation following surgery or endovenous laser ablation (EVLA) for great saphenous vein reflux.
  89. ncbi Feasibility of sequential thrombus aspiration and filter distal protection in the management of very high thrombus burden lesions
    Francesco Burzotta
    Catholic University of the Sacred Heart, Cardiology Department, Rome, Italy
    J Invasive Cardiol 19:317-23. 2007
    ..A series of thrombectomy and distal filter devices have been developed to limit distal embolization during percutaneous coronary interventions (PCI)...
  90. ncbi Development of valves in the small saphenous vein in human fetuses
    Małgorzata Czarniawska-Grzesińska
    Department of Anatomy, Karol Marcinkowski University School of Medical Sciences, Poznan, Poland
    Folia Morphol (Warsz) 61:37-42. 2002
    ..During development more valves were found in the upper part of the small saphenous vein. The height of valves increases with age and differs between particular valves of the same vein.
  91. ncbi Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions
    Ralf E Harskamp
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Ann Surg 257:824-33. 2013
    ..To review our current understanding of the epidemiology and pathogenesis of vein graft failure (VGF), give an overview of current preventive and interventional measures, and explore strategies that may improve vein graft patency...
  92. ncbi Nitric oxide-donating aspirin (NCX 4016) inhibits neointimal thickening in a pig model of saphenous vein-carotid artery interposition grafting: a comparison with aspirin and morpholinosydnonimine (SIN-1)
    Song Wan
    Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    J Thorac Cardiovasc Surg 134:1033-9. 2007
    ..It was suggested, therefore, that co-administration of nitric oxide with aspirin may compensate for these limitations. A drug class that fulfills this pharmacologic criterion is nitric oxide-donating aspirin (NCX 4016)...
  93. ncbi Comparison of saphenous vein graft versus right gastroepiploic artery to revascularize the right coronary artery: a prospective randomized clinical, functional, and angiographic midterm evaluation
    David Glineur
    Department of Cardiovascular Medicine and Surgery, University of Louvain Medical School, Brussels, Belgium
    J Thorac Cardiovasc Surg 136:482-8. 2008
    Despite its theoretic advantage over saphenous vein grafts, the right gastroepiploic artery graft has not been accepted as the ideal conduit to revascularize the right coronary artery...
  94. ncbi A procedure to simulate coronary artery bypass graft surgery
    Fernando Cacho
    Institute for Structural Analysis, Computational Biomechanics, Graz University of Technology, Graz, Austria
    Med Biol Eng Comput 45:819-27. 2007
    ..analyses are based on actual three-dimensional vessel dimensions of a human coronary artery and a human saphenous vein. The analyses consider the structure of the end-to-side anastomosis, the residual stresses and the typical ..
  95. ncbi Heparin-induced thrombocytopenia presenting with thrombosis of multiple saphenous vein grafts and myocardial infarction
    Ernesto Ayala
    Division of Hematology Oncology, University of Miami School of Medicine Jackson Memorial Hospital and Veterans Affairs Medical Center, Miami, Florida, USA
    Am J Hematol 76:383-5. 2004
    ..heparin-induced thrombocytopenia after coronary artery bypass graft with resulting thrombosis of multiple saphenous vein grafts and myocardial infarction after heparin exposure...
  96. ncbi Human saphenous vein and coronary bypass surgery: ultrastructural aspects of conventional and "no-touch" vein graft preparations
    S R Ahmed
    Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, London, UK
    Histol Histopathol 19:421-33. 2004
    ..The aim of this study was to compare the ultrastructural features of human saphenous vein (SV) grafts harvested conventionally and grafts prepared using an atraumatic 'no-touch' harvesting technique ..
  97. ncbi Incomplete removal of great saphenous vein is the most common cause for recurrent varicose veins
    Dhiraj Joshi
    Department of General and Vascular Surgery, Watford General Hospital, Watford, UK
    Angiology 62:198-201. 2011
    Hie-tie and great saphenous vein (GSV) stripping decreases recurrence of varicose veins (VVs). However, varying lengths of residual-GSV are observed in patients with previous GSV stripping. This may explain high recurrence rates of VVs...
  98. ncbi Use of single saphenous interposition vein graft for primary arterial circuit and secondary recipient site in head and neck reconstruction: a case report
    Kao Ping Chang
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Head Neck 29:412-5. 2007
    ..Free flaps transferred to head and neck regions carry a higher risk of failure, which may be expected to increase more with the use of vein grafts...
  99. ncbi An isolated aneurysm of the thigh anterolateral branch of the greater saphenous vein in a young patient presenting as an inguinal hernia
    Giustino Marcucci
    Department of Surgery, Vascular and Endovascular Surgery Unit, San Paolo Hospital, Civitavecchia, Rome, Italy gmarcromaalice it
    Interact Cardiovasc Thorac Surg 10:654-5. 2010
    We report the first case of isolated aneurysm of the anterolateral branch of the greater saphenous vein in a 24-year-old man. The aneurysm was initially confused with an inguinal hernia...
  100. ncbi Evaluation of less invasive method for saphenous vein harvest in patients with type II diabetes
    Giuseppe Nasso
    Division of Cardiac Surgery, Centro di Ricerca e Formazione ad Alta Tecnologia nelle Scienze Biomediche, Universita Cattolica del Sacro Cuore, Loc Tappino, Campobasso, Italy
    J Cardiovasc Med (Hagerstown) 8:511-6. 2007
    Diabetes mellitus is an established risk factor for leg wound healing complications after great saphenous vein harvest. Leg healing complications occur in 1-25% of coronary artery bypass graft patients, and are often underestimated.
  101. ncbi Long-term preservation of human saphenous vein by green tea polyphenol under physiological conditions
    Dong Wook Han
    Department of Medical Engineering, Yonsei University College of Medicine, Seoul, South Korea
    Tissue Eng 11:1054-64. 2005
    ..the possible effects of green tea polyphenolic compounds (GTPCs) on the longterm preservation of the human saphenous vein (HSV) were investigated under physiological conditions. HSV segments were pretreated with GTPCs (0.5 or 1...

Research Grants62

  1. RECEPTOR KINASE GENE THERAPY FOR NEOINTIMAL HYPERPLASIA
    Neil Freedman; Fiscal Year: 2002
    ..PTCA and saphenous vein grafts in CABG are both complicated by proliferation of smooth muscle cells in the vessel subintima, in a ..
  2. PTEN Gene Therapy for Vein Graft Disease
    Christopher D Kontos; Fiscal Year: 2010
    ..and optimize transduction of vascular smooth muscle cells and vein grafts;and 2) Compare 6-month aortocoronary saphenous vein graft (SVG) patency rates and intimal hyperplasia in dogs following ex vivo vein graft treatment with AdPTEN, ..
  3. Effect of Extended-Release Niacin on Saphenous Vein Graft Atherosclerosis
    Emmanouil Brilakis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aortocoronary saphenous vein bypass graft (SVG) failure is common and is associated with high morbidity and mortality...
  4. SMOOTH MUSCLE CELL PROLIFERATION IN HUMAN CORONARY ARTERY BYPASS GRAFTS
    Devendra K Agrawal; Fiscal Year: 2012
    ..Invasive techniques such as coronary artery bypass grafting (CABG) using the saphenous vein (SV) or internal mammary artery (IMA) are used to alleviate the sequelae of arterial occlusion...
  5. Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous Insufficiency
    Raouf A Khalil; Fiscal Year: 2013
    ..Also, varix segments of varicose veins demonstrate reduced contraction as compared to control saphenous vein. These novel findings make it important to investigate the link between vein wall stretch and MMPs in the ..
  6. Prasugrel for prevention of early saphenous vein graft thrombosis
    Emmanouil Brilakis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Early aortocoronary saphenous vein bypass graft (SVG) failure is common and is associated with high morbidity and mortality...
  7. Methods To Reduce Vein Harvest Injury
    Joyce Cheung-Flynn; Fiscal Year: 2013
    Autologous human saphenous vein (HSV) continues to be the most widely used conduit for approximately 1,000,000 coronary artery bypass grafting (CABG) and peripheral vascular (PV) revascularization procedures performed each year...
  8. Genetic Engineering of Vein Bypass Grafts in Vascular and Cardiovascular Surgery
    Frank W LoGerfo; Fiscal Year: 2013
    ..silencing target genes (IL-6, IL-8, and PKC[unreadable], and Col1A1) and achieving protein knockdown in human saphenous vein endothelial cell (EC) and SMC cultures and confirming this effectiveness ex vivo in the intact wall of the ..
  9. Smart Polymer Based MK2 Inhibitor to Suppress Vascular Graft Intimal Hyperplasia
    CRAIG LEWIS DUVALL; Fiscal Year: 2012
    ..Preliminary data have shown a reduction in IH in human saphenous vein samples delivered MK2i via fusion to a cell penetrating peptide (CPP-MK2i)...
  10. PRESERVATION OF ENDOTHELIAL DEPENDENT RELAXATION
    Colleen M Brophy; Fiscal Year: 2013
    ..The most common conduit used to bypass stenotic and occlusive atherosclerotic lesions is the saphenous vein. The saphenous vein (HSV) is harvested from the lower extremity and prepared for use as an arterial conduit...
  11. Development of a Microstructurally Inspired and Compliance Matched Tissue Enginee
    JONATHAN PIETER VANDE GEEST; Fiscal Year: 2013
    ..The need for an alternative vascular substitute is warranted as autologous vessels (e.g., mammary artery, saphenous vein) are oftentimes unavailable due to prior use or cardiovascular disease...
  12. Targeting the Extracellular Matrix to Inhibit Saphenous Vein Graft (SVG) Failure
    Thomas N Wight; Fiscal Year: 2012
    ..of this proposal is for Matrexa to develop a protein product that will prevent intimal hyperplasia in human saphenous vein grafts (SVG) with the objective of reducing the exceedingly high failure rate of these surgical procedures...
  13. Enhancing Vein Graft Patency By Preserving Endothelial Function
    Igor V Voskresensky; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Over a million coronary bypass procedures using human saphenous vein (HSV) are performed yearly worldwide. Nearly half of these grafts fail over a period of 12 to 18 months...
  14. Biodegradable Synthetic Vascular Graft
    Yadong Wang; Fiscal Year: 2013
    ..The graft will function immediately as a non-thrombogenic conduit for blood flow in a similar fashion as a saphenous vein in coronary artery bypass surgery...
  15. Enhancing vein graft viability
    MICHAEL JAMES OSGOOD; Fiscal Year: 2012
    ..1,000,000 aortocoronary and peripheral vascular revascularizations are performed each year using human saphenous vein (HSV). The leading cause of graft failure is the subsequent development of intimal hyperplasia...
  16. Prevention of Vein Graft Intimal Hyperplasia with Optimized Human Apyrase
    Ridong Chen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The saphenous vein is the most commonly used graft for coronary artery bypass and peripheral bypass surgery, but has poor patency...
  17. Vascular Tissue Invasion by Porphyromonas gingivalis
    Ling Li; Fiscal Year: 2005
    ..g. using novel human organ and cell culture systems. Human saphenous vein organ culture that maintains 3-D structure of vascular tissue will be used for the first time to evaluate ..
  18. TNF-INHIBITOR GENE THERAPY FOR NEOINTIMAL HYPERPLASIA
    Karsten Peppel; Fiscal Year: 2004
    ..The annual cost needed to treat PCI restenosis alone exceeds $2 billion. PCI and saphenous vein CABG surgery both lead to significant injury of the underlying vessel wall, causing endothelial dysfunction ..
  19. PULMONARY ARTERY NEUROEFFECTOR JUNCTIONS
    DUANE RORIE; Fiscal Year: 1992
    ..NE) dynamics at neuroeffector junctions are different in pulmonary artery than in coronary artery or in saphenous vein and are, in addition, changed during acute or chronic hypoxia in a direction which increases the availability ..
  20. POSTMENOPAUSAL HORMONE REPLACEMENT THERAPY AFTER CABG
    Pamela Ouyang; Fiscal Year: 2001
    ..Patients may present several years later with recurrent symptoms that may be a result of occlusion of saphenous vein grafts, development of atherosclerotic disease in the vein grafts, or progression of underlying disease...
  21. REGULATION OF VENOUS MUSCLE K+ CHANNELS
    NANCY RUSCH; Fiscal Year: 1993
    ..In the rat saphenous vein, chronic pressure load resulted in hyperpolarization, that may be a result of increased membrane K+ ..
  22. VASCULAR RESPONSE TO ALTERATION IN HEMODYNAMIC FLOW
    SHUNICHIRO OKADA; Fiscal Year: 2002
    DESCRIPTION (Adapted from Applicant's Abstract): Saphenous vein graft (SV...
  23. Endovascular Laser Treatment of Varicose Veins
    DILIP PAITHANKAR; Fiscal Year: 2004
    ..diode-laser based technique at a new wavelength for photothermal coagulation and destruction of the greater saphenous vein (GSV) for treatment of varicose veins...
  24. Vessel Structure & Pressure:Transport and Atherogenesis
    DAVID RUMSCHITZKI; Fiscal Year: 2005
    ..In particular, the pulmonary artery (PA) and the large veins such as the inferior vena cava and the saphenous vein are exposed to much lower transmural pressures than the large arteries and are normally resistant to ..
  25. Ex vivo venous gene delivery by pulsed electric-fields
    Nagendu Dev; Fiscal Year: 2004
    ..efficiency of pulsed electric fields for ex vivo DNA transfer into cells of rat inferior vena cava and porcine saphenous vein, respectively...
  26. IMPROVED CORONARY ARTERY BYPASS GRAFT OF 3 MM ID
    Michael Szycher; Fiscal Year: 1999
    ..However, in many cases the saphenous vein is either unsuitable or unavailable (due to previous stripping)...
  27. RECURRENT CAROTID STENOSIS
    EUGENE BERNSTEIN; Fiscal Year: 1990
    ..dose response studies in baboon models of arterial thrombus formation, and positive clinical trials in a) saphenous vein bypass, and b) peripheral arterial occlusive disease showing efficacy of the aspirin/dipyridamole combination ..
  28. Development of a vasoactive biogel
    Colleen Brophy; Fiscal Year: 2002
    ..of cardiovascular disease often involves surgically bypassing occluded segments of blood vessels with human saphenous vein grafts...
  29. PLATELET INHIBITORS: EFFECT ON CORONARY BYPASS GRAFTS
    Michael Kaye; Fiscal Year: 1980
    Since occlusion of coronary artery saphenous vein bypass grafts occurs and negates the benefits of surgery in up to 23% of patients, we have conducted experiments to elucidate the mechanisms of occlusion as well as experiments to ..
  30. VEIN GRAFT PRESERVATION: THROMBOSIS & NEOINTIMAL DISEASE
    Yoshifumi Naka; Fiscal Year: 2004
    ..Recent data shows that the process of saphenous vein harvest from humans results in marked upregulation of P-selectin on the endothelial surface...
  31. Diabetic Proteome and Dysregulated Vascular Phenotype
    Lakshman Sandirasegarane; Fiscal Year: 2006
    ..Recent studies have shown that atherectomy specimens from angioplasty patients, injured human saphenous vein, and streptozotocin-diabetic rat VSMC exhibit decreased expression of differentiation proteins, including SM ..
  32. IMPROVED CORONARY ARTERY BYPASS GRAFT OF 3 MM ID
    Michael Szycher; Fiscal Year: 1999
    ..However, in many cases the saphenous vein is either unsuitable or unavailable (due to previous stripping)...
  33. A CONTROLLED TRIAL TO REVERSE CORONARY ATHEROSCLEROSIS
    Frank Sacks; Fiscal Year: 1991
    ..who will have received medical treatment for their coronary disease and in 90 patients who will have received saphenous vein coronary artery bypass grafts...
  34. BARI DATA COORDINATING CENTER
    Katherine Detre; Fiscal Year: 2002
    ..However, it is unknown how failure of additional saphenous vein grafts will affect outcome...
  35. Gene Transfer to Prevent Intimal Hyperplasia in CABG
    Brian Lima; Fiscal Year: 2005
    b>Saphenous vein grafts remain an important conduit for surgical coronary revascularization. These conduits, however, have limited durability...
  36. BIOMECHANICAL PRECONDITIONING OF HUMAN VEIN GRAFTS
    David Vorp; Fiscal Year: 2003
    ..Abstract): Five-hundred thousand coronary artery bypass surgeries are performed every year, and the human saphenous vein (HSV) is the most often used conduit in this procedure...
  37. FEASIBILITY TRIAL OF A NOVEL CORONARY BYPASS CONDUIT
    Charles Love; Fiscal Year: 2000
    ..Benchmarks for evaluation will be comparison to an autologous saphenous vein or free internal mammary artery graft...
  38. USE OF XENOGENIC MATRIX AS VASCULAR BYPASS CONDUIT
    Steven Goldstein; Fiscal Year: 2001
    ..Allogeneic and autologous saphenous vein is often used but the availability of suitable conduit limits autologous procedures, and the supply of ..
  39. PHYSIOLOGY & HISTOPATHOLOGY OF ARTERIALIZED VEIN GRAFTS
    JOHN VASKO; Fiscal Year: 1980
    b>Saphenous vein grafts will be interimposed at a 90 degrees proximal angle between the right and left external iliac arteries in small animals...
  40. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Paul Stein; Fiscal Year: 2003
    ..4) The team of investigators is strong, and has collaborated previously in successful research in PE. ..
  41. Vein wall remodeling after DVT is matrix metalloproteinase dependent
    Peter Henke; Fiscal Year: 2009
    ..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
  42. Prospective Investigation for Pulmonary Embolism Dx III
    Paul Stein; Fiscal Year: 2008
    ..abstract_text> ..
  43. Thrombus resolution is CXC chemokine dependent
    Peter Henke; Fiscal Year: 2006
    ..abstract_text> ..
  44. QUANTIFICATION OF FACTORS LEADING TO VEIN GRAFT FAILURE
    Daniel Leotta; Fiscal Year: 2004
    ..By developing methods to detect the early indicators of impending failure, this project offers the opportunity to extend the useful life of the grafts by permitting early treatment of the lesions. ..
  45. Particulate Air Pollution and Acute Ischemic Stroke
    Gregory Wellenius; Fiscal Year: 2006
    ..These hypotheses will be tested in patient populations with complimentary strengths. ..
  46. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ....
  47. A Preclinical Model of Adolescent Toluene Abuse in Rats
    Scott Bowen; Fiscal Year: 2005
    ..The model also has the potential to assist in devising effective treatments and prevention strategies for adolescent inhalant abuse. ..
  48. NON-INVASIVE EVALUATION OF ICP AND HEMODYNAMICS
    David Newell; Fiscal Year: 2002
    ..We then propose to test this method for accuracy of continuous recording of ICP under ICU conditions. ..
  49. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2002
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
  50. Mechanism of Endothelial Dysfunction in Diabetes
    Adviye Ergul; Fiscal Year: 2004
    ..The results will lead to the development of novel therapeutic targets for the high-risk diabetic patients and may identify subgroups of patients that would be more suitable for these new treatment strategies. ..
  51. Aging Venous Thrombi with Ultrasound Elasticity Imaging
    Jonathan Rubin; Fiscal Year: 2005
    ..abstract_text> ..
  52. Ultrasound Elasticity Imaging in Breast Cancer Screening
    Jonathan Rubin; Fiscal Year: 2006
    ..Success could lead to a unique ultrasound-based imaging mode for breast cancer screening. ..
  53. SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAM
    K Kent; Fiscal Year: 2005
    ..By means of this structure, the Department of Surgery is endeavoring to increase the number of young surgical investigators committed to investigative excellence in academic surgical oncology. ..
  54. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
    ..To study the specific aims of the project the effects of RTX will be examined in rats by behavioral methods; and whole cell voltage-clamp technique will be used to identify a mechanism for impulse failure induced by RTX. ..
  55. MESA Family Study
    Wendy Post; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  56. Cerebrovascular mechanisms of ischemic injury in diabetes
    Adviye Ergul; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. FLT3-LIGAND, IMMUNOMODULATION AND THERAPY IN ASTHMA
    DEVENDRA AGRAWAL; Fiscal Year: 2008
    ..The long-term goal of this study is to better define the potential mechanisms of action of FL to prevent and reverse allergic airway inflammation and associated changes in pulmonary function. ..
  58. Osteoprotegerin and osteopontin in aortic aneurysm
    Jonathan Golledge; Fiscal Year: 2009
    ..Understanding the role of these calcium-controlling proteins in artery weakness and how drug therapy can interfere in these effects is an important step in the development of new treatment for aortic aneurysm. ..
  59. Self-administration of abused inhalants in mice
    Scott Bowen; Fiscal Year: 2004
    ....
  60. Articulated Robot for Epicardial Interventions
    Marco A Zenati; Fiscal Year: 2010
    ..We also believe that the HARP may expand the therapeutic options for other non-cardiac endoscopic applications . ..
  61. TGF-BETA, CHLORIDE CHANNELS AND APOPTOSIS OF AIRWAY EPITHELIAL CELLS
    Devendra K Agrawal; Fiscal Year: 2010
    ..Such investigations would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease. ..
  62. Vascular Protection & Endothelin B Receptors in Diabetes
    Adviye Ergul; Fiscal Year: 2009
    ..abstract_text> ..