Genomes and Genes
Summary: The veins that return the oxygenated blood from the lungs to the left atrium of the heart.
Publications313 found, 100 shown here
- Intra-atrial pressure increases rate and organization of waves emanating from the superior pulmonary veins during atrial fibrillationJerome Kalifa
Institute for Cardiovascular Research, Department of Pharmacology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA
Circulation 108:668-71. 2003..We hypothesized that elevation of intra-atrial pressure elicits high-frequency and spatio-temporally organized left atrial (LA) sources emanating from the superior pulmonary veins.
- Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardiumMathilda T M Mommersteeg
Heart Failure Research Center, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Circ Res 101:902-9. 2007..In conclusion, our data suggest a cellular mechanism for pulmonary myocardium formation and highlight the key roles played by Pitx2c and Nkx2-5 in its formation and identity...
- Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillationCarlo Pappone
Department of Cardiology, San Raffaele University Hospital, Via Olgettina 60, 20132, Milan, Italy
Circulation 109:327-34. 2004..This study assesses the incremental benefit of vagal denervation by radiofrequency in preventing recurrent AF in a large series of patients undergoing CPVA for paroxysmal AF...
- Electrical connections between pulmonary veins: implication for ostial ablation of pulmonary veins in patients with paroxysmal atrial fibrillationAtsushi Takahashi
Cardiovascular Center, Tsuchiura Kyodo Hospital, Tsuchiura shi, Ibaraki Ken, Japan
Circulation 105:2998-3003. 2002Electrical disconnection of the myocardial extensions into arrhythmogenic pulmonary veins (PVs) is recognized as a curative technique for paroxysmal atrial fibrillation (AF)...
- Circumferential pulmonary-vein ablation for chronic atrial fibrillationHakan Oral
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, USA
N Engl J Med 354:934-41. 2006..We conducted a randomized, controlled trial of circumferential pulmonary-vein ablation for the treatment of chronic atrial fibrillation...
- Major vascular anomalies in Turner syndrome: prevalence and magnetic resonance angiographic featuresVincent B Ho
Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Circulation 110:1694-700. 2004..To better understand the prevalence and pathogenesis of cardiovascular defects in TS, we prospectively evaluated a group of asymptomatic adult volunteers with TS using magnetic resonance (MR) angiography...
- Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggersMark D Levin
Penn Cardiovascular Institute and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 119:3420-36. 2009..It is often initiated by ectopic beats arising from the pulmonary veins and atrium, but the source and mechanism of these beats remains unclear...
- Pulmonary venous isolation by antral ablation with a large cryoballoon for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and non-randomised comparison with pulmonary venous isolation by radiofrequency ablationPipin Kojodjojo
Department of Cardiac Electrophysiology, St Mary s Hospital, Imperial College NHS Healthcare Trust, London, UK
Heart 96:1379-84. 2010..The aim of this study was to investigate the efficacy of a strategy using a large cryoablation balloon to perform antral cryoablation with 'touch-up' ostial cryoablation for PVI in patients with paroxysmal and persistent AF...
- Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulationEugene Patterson
University of Oklahoma Health Sciences Center and Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA
Heart Rhythm 2:624-31. 2005..Rapid firing within pulmonary vein sleeves frequently initiates atrial fibrillation. The role of the autonomic nervous system in facilitating spontaneous firing is unknown...
- Worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillationRiccardo Cappato
Arrhythmia and Electrophysiology Center, Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
Circulation 111:1100-5. 2005..The purpose of this study was to conduct a worldwide survey investigating the methods, efficacy, and safety of catheter ablation (CA) of atrial fibrillation (AF)...
- Real-time dominant frequency mapping and ablation of dominant frequency sites in atrial fibrillation with left-to-right frequency gradients predicts long-term maintenance of sinus rhythmFelipe Atienza
Hospital General Universitario Gregorio Maranon, Madrid, Spain
Heart Rhythm 6:33-40. 2009..Spectral analysis identifies localized sites of high-frequency activity during atrial fibrillation (AF)...
- Thoracoscopic video-assisted pulmonary vein antrum isolation, ganglionated plexus ablation, and periprocedural confirmation of ablation lesions: first results of a hybrid surgical-electrophysiological approach for atrial fibrillationSébastien P J Krul
Heart Failure Research Center, Department of Cardiology and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
Circ Arrhythm Electrophysiol 4:262-70. 2011..We hypothesize that meticulous electrophysiological confirmation of PVI results in fewer recurrences of AF during follow-up...
- Minimally invasive surgical atrial fibrillation ablation: patient selection and resultsFrederick T Han
Division of Cardiology and Division of Cardiothoracic Surgery, Virginia Commonwealth University, Richmond, Virginia
Heart Rhythm 6:S71-6. 2009..We review the safety and efficacy of MISAA, discuss considerations for optimal patient selection for MISAA, and review the advantages/disadvantages of MISAA compared with catheter ablation and the maze procedure...
- MDCT of partial anomalous pulmonary venous return (PAPVR) in adultsMai Lan Ho
Department of Internal Medicine, St Luke s Hospital, Chesterfield, MO 63005, USA
J Thorac Imaging 24:89-95. 2009..The purpose of this study was to determine the lobar distribution and associated radiologic/clinical findings of partial anomalous pulmonary venous return (PAPVR) in the adult population using multidetector computed tomography (MDCT)...
- Linear cryoablation of the left atrium versus pulmonary vein cryoisolation in patients with permanent atrial fibrillation and valvular heart disease: correlation of electroanatomic mapping and long-term clinical resultsFiorenzo Gaita
Division of Cardiology, Department of Cardiology, Civil Hospital Asti, Via Botallo, 4, 14100 Asti, Italy
Circulation 111:136-42. 2005..The primary end point was to assess the persistence of sinus rhythm (SR) off antiarrhythmic drugs (AADs) at 2-year follow-up and to correlate clinical outcome with surgical results validated with electroanatomic mapping (EAM)...
- Normal and abnormal development of pulmonary veins: state of the art and correlation with clinical entitiesYvonne L Douglas
Department of Cardio Thoracic Surgery, University Medical Center Groningen, University of Groningen, The Netherlands
Int J Cardiol 147:13-24. 2011Interest for the pulmonary veins has increased in the past decade after the potential arrhythmogenicity of the myocardial sleeve surrounding these structures has been recognized...
- Pulmonary vein isolation with Mesh Ablator versus cryoballoon catheters: 6-month outcomesRobert Hofmann
Cardiovascular Division, City Hospital Linz, Krankenhausstrasse 9, 4021 Linz, Austria
J Interv Card Electrophysiol 29:179-85. 2010..We sought to compare the results of pulmonary vein (PV) ablation using the high-density Mesh Ablator catheter (MESH) versus the cryoballoon (CRYO)...
- First robotic endoscopic epicardial isolation of the pulmonary veins with microwave energy in a patient in chronic atrial fibrillationDidier F Loulmet
Division of Cardiac Surgery, Lenox Hill Hospital, New York, New York 10021, USA
Ann Thorac Surg 78:e24-5. 2004The pulmonary veins have been demonstrated to play an important role in generating atrial fibrillation...
- Increased intensity of anticoagulation may reduce risk of thrombus during atrial fibrillation ablation procedures in patients with spontaneous echo contrastJian Fang Ren
Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Cardiovasc Electrophysiol 16:474-7. 2005..The aim of this study was to determine if the intensity of anticoagulation reduces LA thrombus formation during pulmonary vein isolation procedure in patients with AF and spontaneous echo contrast (SEC)...
- Long-term clinical outcome of extensive pulmonary vein isolation-based catheter ablation therapy in patients with paroxysmal and persistent atrial fibrillationShinsuke Miyazaki
Cardiovascular Center, Yokosuka Kyosai Hospital, 1 16, Yonegahamadori, Yokosuka, Kanagawa 238 8558, Japan
Heart 97:668-73. 2011..To examine the long-term clinical outcomes of patients undergoing catheter ablation (CA) for either paroxysmal (PAF) or persistent atrial fibrillation (PsAF) using an extensive pulmonary vein isolation (EPVI)-based strategy...
- Arrhythmogenic substrate of the pulmonary veins assessed by high-resolution optical mappingRishi Arora
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Circulation 107:1816-21. 2003It has recently been recognized that atrial fibrillation can originate from focal sources in the pulmonary veins (PVs). However, the mechanisms of focal atrial fibrillation have not been well characterized...
- Pacing-induced spontaneous activity in myocardial sleeves of pulmonary veins after treatment with ryanodineHaruo Honjo
Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
Circulation 107:1937-43. 2003..results of radiofrequency catheter ablation therapy suggest that high-frequency focal activity in the pulmonary veins (PVs) plays important roles in the initiation and perpetuation of atrial fibrillation, but the mechanisms ..
- Repolarization and activation restitution near human pulmonary veins and atrial fibrillation initiation: a mechanism for the initiation of atrial fibrillation by premature beatsSanjiv M Narayan
University of California and Veterans Affairs Medical Center, San Diego, California, USA
J Am Coll Cardiol 52:1222-30. 2008The authors sought to study mechanisms to explain why single premature atrial complexes (PACs) from the pulmonary veins (PVs) may initiate human atrial fibrillation (AF).
- Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexiZhibing Lu
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
Cardiovasc Res 84:245-52. 2009..This study sought to investigate the autonomic mechanism underlying the rapid firings at various sites by systematic ablation of multiple ganglionated plexi (GP)...
- Regulation of cGMP-dependent protein kinase-mediated vasodilation by hypoxia-induced reactive species in ovine fetal pulmonary veinsSewite Negash
Division of Neonatology, Harbor UCLA Medical Center, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA
Am J Physiol Lung Cell Mol Physiol 293:L1012-20. 2007..However, after 4 h of hypoxia, PKG nitration and decreased PKG expression are involved...
- Utility of exit block for identifying electrical isolation of the pulmonary veinsEdward P Gerstenfeld
University of Pennsylvania Medical Center, Philadelphia 19104, USA
J Cardiovasc Electrophysiol 13:971-9. 2002Electrical isolation of the pulmonary veins (PVs) to treat paroxysmal atrial fibrillation (AF) has been described using "entry block" as an endpoint for PV isolation...
- Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablationDaniela Husser
Department of Electrophysiology, Heart Center, Leipzig, Germany
J Am Coll Cardiol 55:747-53. 2010..This study tested the hypothesis that chromosome 4q25 single-nucleotide polymorphisms (SNPs) associate with atrial fibrillation (AF) recurrence after catheter ablation...
- Intracellular calcium dynamics and acetylcholine-induced triggered activity in the pulmonary veins of dogs with pacing-induced heart failureChung Chuan Chou
Department of Medicine, Second Section of Cardiology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan
Heart Rhythm 5:1170-7. 2008..Heart failure increases autonomic nerve activities and changes intracellular calcium (Ca(i)) dynamics...
- Differences in repeating patterns of complex fractionated left atrial electrograms in longstanding persistent atrial fibrillation as compared with paroxysmal atrial fibrillationEdward J Ciaccio
Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA
Circ Arrhythm Electrophysiol 4:470-7. 2011..It was hypothesized that this may result from a greater degree of repetitiveness in CFAE patterns at disparate left atrial (LA) sites in longstanding AF...
- Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veinsS L Chang
Division of Cardiology and Cardiovascular Research Center, National Yang Ming University School of Medicine and Veterans General Hospital, Taipei, Taiwan
Heart 93:82-8. 2007Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects.
- Dissociated pulmonary vein potentials following antral pulmonary vein isolation for atrial fibrillation: impact on long-term outcomeGeoffrey Lee
The Heart Centre, The Alfred Hospital, Melbourne 3004, Australia
Heart 97:579-84. 2011..Dissociated pulmonary vein potentials (dPVP) may reflect abnormal PV automaticity, indicate more extensive PV muscular sleeve or may simply be an epiphenomenon...
- Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent mannerNele S Pauwels
Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
Respir Res 11:134. 2010..Since Pentraxin-3 (PTX3) is a tuner of inflammatory responses and is produced by endothelial and inflammatory cells upon stimuli such as interleukin-1β (IL-1β), we hypothesized that PTX3 is involved in COPD pathogenesis...
- Rationale and design of the FreezeAF trial: a randomized controlled noninferiority trial comparing isolation of the pulmonary veins with the cryoballoon catheter versus open irrigated radiofrequency ablation in patients with paroxysmal atrial fibrillationArmin Luik
IV Medizinische Klinik des Staedtischen Klinkums Karlsruhe, Germany
Am Heart J 159:555-560.e1. 2010..The criterion standard is the isolation of the pulmonary veins (PVs) using radiofrequency (RF) energy in combination with an open irrigated tip catheter...
- Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sitesNazira Ozgen
Center for Molecular Therapeutics, Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Cardiovasc Res 75:758-69. 2007Atrial fibrillation is often initiated by bursts of ectopic activity arising in the pulmonary veins. We have previously shown that a 3-h intermittent burst pacing protocol (BPP), mimicking ectopic pulmonary vein foci, shortens action ..
- Segmental ostial ablation to isolate the pulmonary veins during atrial fibrillation: feasibility and mechanistic insightsHakan Oral
Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor 48109 0022, USA
Circulation 106:1256-62. 2002..The purpose of this study was to determine the feasibility and mechanistic implications of segmental pulmonary vein (PV) ostial ablation during atrial fibrillation (AF)...
- Partial anomalous pulmonary venous connection: diagnosis by transesophageal echocardiographyN M Ammash
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
J Am Coll Cardiol 29:1351-8. 1997..This study sought to demonstrate that with proper technique, identification of the normal and abnormal pulmonary venous connection can be made with confidence using transesophageal echocardiography (TEE)...
- Catheter ablation of paroxysmal atrial fibrillation initiated by non-pulmonary vein ectopyWei Shiang Lin
Division of Cardiology, Department of Medicine, National Yang Ming University, Cardiovascular Research Institute, Taipei Taichung Veterans General Hospital, Taiwan
Circulation 107:3176-83. 2003..Most of the ectopic beats initiating paroxysmal atrial fibrillation (PAF) originate from the pulmonary vein (PV). However, only limited data are available on PAF originating from the non-PV areas...
- Long-term clinical results of 2 different ablation strategies in patients with paroxysmal and persistent atrial fibrillationFiorenzo Gaita
Division of Cardiology, Cardinal Massaia Hospital, University of Turin, Asti, Italy
Circ Arrhythm Electrophysiol 1:269-75. 2008..Data regarding the long-term efficacy of atrial fibrillation (AF) ablation are still lacking...
- Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic gangliaKristina Lemola
Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
Circulation 117:470-7. 2008..However, PV ablation procedures also can affect intracardiac autonomic ganglia. The present study examined the relative role of PVs versus peri-PV autonomic ganglia in an experimental vagal AF model...
- Pre-procedural predictors of atrial fibrillation recurrence after circumferential pulmonary vein ablationAntonio Berruezo
Arrhythmia Section, Thorax Institute, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
Eur Heart J 28:836-41. 2007..The objective of the study was to identify predictors of AF recurrence after a standardized CPVA procedure...
- Pulmonary vein isolation for paroxysmal and persistent atrial fibrillationHakan Oral
Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
Circulation 105:1077-81. 2002The pulmonary veins (PVs) have been demonstrated to often play an important role in generating atrial fibrillation (AF)...
- Characterization of conduction recovery after pulmonary vein isolation using the "single big cryoballoon" techniqueAlexander Furnkranz
Department of Cardiology, Asklepios Klinik St Georg, Hamburg, Germany
Heart Rhythm 7:184-90. 2010..Systematic analysis of conduction recovery occurring after CB-PVI and causing recurrent atrial fibrillation has not yet been performed...
- Safety and efficacy of pulmonary vein antral isolation in patients with obstructive sleep apnea: the impact of continuous positive airway pressureDimpi Patel
St David s Medical Center, Austin, TX, USA
Circ Arrhythm Electrophysiol 3:445-51. 2010..Obstructive sleep apnea (OSA) may be associated with pulmonary vein antrum isolation (PVAI) failure. The aim of the present study was to investigate if treatment with continuous positive airway pressure (CPAP) improved PVAI success rates...
- Fatal end of a safety algorithm for pulmonary vein isolation with use of high-intensity focused ultrasoundKars Neven
Asklepios Klinik St Georg, Department of Cardiology, Hamburg, Germany
Circ Arrhythm Electrophysiol 3:260-5. 2010..Therefore, we evaluated an esophageal temperature (ET)-guided safety algorithm to apply HIFU safely...
- Clinical predictors and outcomes associated with acute return of pulmonary vein conduction during pulmonary vein isolation for treatment of atrial fibrillationWilliam H Sauer
University of Colorado at Denver and Health Sciences Center, USA
Heart Rhythm 3:1024-8. 2006..Pulmonary vein electrical isolation (PVI) is an effective treatment for atrial fibrillation (AF). However, recurrence of pulmonary vein (PV) conduction after ablation may limit long-term success...
- Randomized study of surgical isolation of the pulmonary veins for correction of permanent atrial fibrillation associated with mitral valve diseaseAlvaro Albrecht
Department of Cardiovascular Surgery, Instituto de Cardiologia do Rio Grande do Sul Fundação Universitária de Cardiologia IC FUC, Porto Alegre, Brazil
J Thorac Cardiovasc Surg 138:454-9. 2009..Simpler techniques and ablation methods should have their efficacy tested in clinical practice. Our objective was to evaluate the effectiveness of surgical pulmonary vein isolation as compared with the Cox maze procedure...
- Outcomes after surgical treatment of children with partial anomalous pulmonary venous connectionBahaaldin Alsoufi
The Cardiac Centre, Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
Ann Thorac Surg 84:2020-6; discussion 2020-6. 2007..We explore early results and time-related morbidity after surgical repair of partial anomalous pulmonary venous connection (PAPVC) at our institution...
- Aging increases pulmonary veins arrhythmogenesis and susceptibility to calcium regulation agentsWanwarang Wongcharoen
National Yang Ming University, School of Medicine, Taipei, Taiwan
Heart Rhythm 4:1338-49. 2007Aging and pulmonary veins (PVs) play a critical role in the pathophysiology of atrial fibrillation. Abnormal Ca(2+) regulation and ryanodine receptors are known to contribute to PV arrhythmogenesis.
- Origin, differentiation, and maturation of human pulmonary veinsSusan M Hall
Unit of Vascular Biology and Pharmacology, Institute of Child Health, University College, London, United Kingdom
Am J Respir Cell Mol Biol 26:333-40. 2002..Little is known of the early development of the pulmonary veins. Using immunohistochemical techniques and serial reconstruction, we studied 18 fetal and neonatal lungs...
- Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillationPierre Jais
Hopital Cardiologique du Haut Leveque, Bordeaux Pessac, France
Circulation 106:2479-85. 2002Atrial fibrillation (AF) is frequently initiated from pulmonary veins (PVs), but little is known of the electrophysiological properties of PVs.
- Randomized study comparing combined pulmonary vein-left atrial junction disconnection and cavotricuspid isthmus ablation versus pulmonary vein-left atrial junction disconnection alone in patients presenting with typical atrial flutter and atrial fibrillatOussama Wazni
Center for Atrial Fibrillation, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 108:2479-83. 2003..Recently it has been demonstrated that the triggers for both AF and AFL may originate in the pulmonary veins (PVs)...
- Interstitial Cajal-like cells (ICLC) in myocardial sleeves of human pulmonary veinsMihaela Gherghiceanu
Victor Babes National Institute of Pathology, Bucharest, Romania
J Cell Mol Med 12:1777-81. 2008We present here evidence for the existence of a new type of interstitial cell in human myocardial sleeves of pulmonary veins: interstitial Cajal-like cell (ICLC)...
- Congenital unilateral pulmonary vein atresia: radiologic findings in three adult patientsL E Heyneman
Department of Radiology, Box 3808, Duke University Medical Center, Rm. 2523 Blue Zone South, Durham, NC 27710, USA
AJR Am J Roentgenol 177:681-5. 2001..MR imaging is helpful in further characterizing the vascular abnormalities. Angiography may help to confirm the diagnosis...
- Anatomic location of pulmonary vein electrical disconnection with balloon-based catheter ablationKaren P Phillips
Section of Pacing and Electrophysiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Cardiovasc Electrophysiol 19:14-8. 2008..catheter ablation for atrial fibrillation, which aim to achieve consistent and rapid ablation encirclement of pulmonary veins (PVs)...
- SQ22536 and W-7 inhibit forskolin-induced cAMP elevation but not relaxation in newborn ovine pulmonary veinsY Gao
Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles, School of Medicine, Torrance, CA 90509, USA
Eur J Pharmacol 418:111-6. 2001The role of cAMP in forskolin-induced relaxation was studied in isolated pulmonary veins of newborn lambs (7-12 days)...
- Anatomical observations of the pulmonary veins with intracardiac echocardiography and hemodynamic consequences of narrowing of pulmonary vein ostial diameters after radiofrequency catheter ablation of atrial fibrillationMonique R M Jongbloed
Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Am J Cardiol 93:1298-302. 2004..Interindividual variations in PV anatomy and insertion in the left atrium were observed. Narrowing of PV ostia after radiofrequency catheter ablation did not produce significant hemodynamic changes...
- The biological "scrabble" of pulmonary arteriovenous malformations: considerations in the setting of cavopulmonary surgeryRobert M Freedom
The Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, The University of Toronto Faculty of Medicine, Toronto, Ontario, Canada
Cardiol Young 14:417-37. 2004..The complex tapestry of these overlapping and intersecting clinical observations will be unfolded in the light of their chronology...
- Congenital atresia of unilateral pulmonary veins associated with a single ventricle: a rare case report and literature reviewHsing Yuan Lee
Department of Pediatrics, Taoyuan Armed Force General Hospital, Taoyuan, Taiwan
Circ J 72:1544-6. 2008Congenital atresia or extreme hypoplasia of individual pulmonary veins is a rare condition that is usually asymptomatic if it only involves 1 or 2 segments of the lungs...
- A region-specific quantitative profile of autonomic innervation of the canine left atrium and pulmonary veinsChong Han Gao
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Auton Neurosci 162:42-7. 2011..Tissue specimens were taken from the canine pulmonary veins (PVs), posterior left atrium (PLA), left atrial roof (LAR), anterior left atrium (ALA), interatrial septum (..
- Autonomic nerves in pulmonary veinsAlex Y Tan
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
Heart Rhythm 4:S57-60. 2007Rapid repetitive activities arising from pulmonary veins may initiate atrial fibrillation...
- Local coronary flow is associated with an unsuccessful complete block line at the mitral isthmus in patients with atrial fibrillationToshiya Kurotobi
Cardiovascular Division, Shiroyama Hospital, Hibikino, Osaka, Japan
Circ Arrhythm Electrophysiol 4:838-43. 2011..However, it is sometimes tough to create a complete MI block line, and the cooling effect because of the local coronary flow may prevent the creation of a successful MI block line...
- Role of the posterior left atrium and pulmonary veins in human lone atrial fibrillation: electrophysiological and pathological data from patients undergoing atrial fibrillation surgeryDerick M Todd
Arrhythmia Service, Division of Cardiology, University of Western Ontario, London, Ontario, Canada
Circulation 108:3108-14. 2003..We used postoperative electrophysiological studies to test the rationale and effects of operative pulmonary venous isolation...
- Assessment of pulmonary veins after atrio-pericardial anastomosis by cardiovascular magnetic resonanceSteven C Greenway
Division of Cardiology, The Hospital for Sick Children, University of Toronto, Ontario, M5G 1X8, Canada
J Cardiovasc Magn Reson 13:72. 2011..between the left atrium and the pulmonary venous contributaries in order to avoid direct suturing of the pulmonary veins during the repair of congenital cardiac malformations...
- Pre- and postoperative evaluation of partial anomalous pulmonary venous return: by 3-dimensional cardiovascular magnetic resonance imaging and cardiovascular computed tomographyJuan A Crestanello
Division of Cardiothoracic Surgery, The Richard M Ross Heart Hospital, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
Tex Heart Inst J 37:113-5. 2010..Herein, we present the cases of 2 patients with partial anomalous pulmonary venous return who underwent preoperative and postoperative evaluation by either method alone, and we discuss the benefits and limitations of each technique...
- A case of an anomalous superior vena cava with anomalous pulmonary veins-when two wrongs do not make a rightSusie N Hong
Department of Medicine, Division of Cardiology Department of Cardiovascular Surgery, New York University School of Medicine, New York, New York, USA
Echocardiography 28:E39-41. 2011..This case illustrates an unusual cause of right-to-left shunting and the utility of venous microbubble injection in its diagnosis...
- Impact of variant pulmonary vein anatomy and image integration on long-term outcome after catheter ablation for atrial fibrillationRoss J Hunter
Cardiology Research Department, Barts and the London NHS Trust and QMUL, St Bartholomew s Hospital, First Floor Dominion House, 60 Bartholomew Close, West Smithfield, London EC1A 7BE, UK
Europace 12:1691-7. 2010..To investigate the impact of variant pulmonary vein (PV) anatomy and the use of three-dimensional image integration (3D-II) on long-term efficacy of catheter ablation for atrial fibrillation (AF)...
- Pressure-guided cryoballoon isolation of the pulmonary veins for the treatment of paroxysmal atrial fibrillationClaudia Herrera Siklody
Department of Electrophysiology, Herz Zentrum Bad Krozingen, Germany
J Cardiovasc Electrophysiol 21:120-5. 2010..The aim of this study was to correlate mechanical PV occlusion with changes in a pressure curve recorded at the distal tip of the cryoballoon catheter...
- A novel mesh electrode catheter for mapping and radiofrequency delivery at the left atrium-pulmonary vein junction: a single-catheter approach to pulmonary vein antrum isolationMauricio S Arruda
Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Cardiovasc Electrophysiol 18:206-11. 2007Electrical isolation of pulmonary veins (PV) by radiofrequency (RF) ablation is often performed in patients with atrial fibrillation (AF)...
- One-year follow-up after pulmonary vein isolation using a single mesh catheter in patients with paroxysmal atrial fibrillationClemens Steinwender
Cardiovascular Division, City Hospital Linz, Austria
Heart Rhythm 7:333-9. 2010..Catheter-based pulmonary vein (PV) isolation has emerged as established therapy for patients with paroxysmal atrial fibrillation (AF)...
- Effects of the NA+ channel blocker pilsicainide on the electrophysiologic properties of pulmonary veins in patients with atrial fibrillationKoichiro Kumagai
Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
J Cardiovasc Electrophysiol 15:1396-401. 2004..However, the effects of Na+ channel blockers on the electrophysiologic properties of pulmonary veins (PVs) are not well characterized...
- Isolated partial anomalous pulmonary venous connection: Diagnostic value of suprasternal color flow imaging and contrast echocardiographySaeed Al-Ahmari
Cardiovascular Division, Echocardiography Laboratory, Mayo Clinic 55905, USA
J Am Soc Echocardiogr 16:884-9. 2003..We describe the value of imaging from suprasternal window with color flow and ultrasound contrast echocardiography in aiding the diagnosis...
- Dual balloon size strategy for cryoisolation of the pulmonary veins in patients with atrial fibrillation: comparison of 23 and 28mm diameter cryoballoonsGeorges Nadji
Service de cardiologie, centre hospitalier de Perpignan, 20, avenue du Languedoc, 66046 Perpignan Cedex, France
Arch Cardiovasc Dis 104:70-6. 2011..Systematic use of a 28mm balloon has been proposed for pulmonary vein cryoisolation in patients with atrial fibrillation...
- Mechanisms underlying sustained firing from pulmonary veins: evidence from pacing maneuvers and pharmacological manipulationSanjay Dixit
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Pacing Clin Electrophysiol 27:1120-9. 2004..Its response to pacing maneuvers argues against sustained reentry and supports triggered activity and/or abnormal automaticity as the mechanisms underlying the phenomenon...
- Cryoballoon pulmonary vein isolation with real-time recordings from the pulmonary veinsK R Julian Chun
From the Department of Cardiology, Asklepios Klinik St Georg, Hamburg, Germany
J Cardiovasc Electrophysiol 20:1203-10. 2009..Cryoballoon (CB) ablation represents a novel technology for pulmonary vein isolation (PVI). We investigated feasibility and safety of CB-PVI, utilizing a novel spiral catheter (SC), thereby obtaining real-time PV potential registration...
- Nitroprusside modulates pulmonary vein arrhythmogenic activityYung Kuo Lin
Department of Biomedical Engineering, National Defense Medical Center, Taipei, Taiwan
J Biomed Sci 17:20. 2010b>Pulmonary veins (PVs) are the most important sources of ectopic beats with the initiation of paroxysmal atrial fibrillation, or the foci of ectopic atrial tachycardia and focal atrial fibrillation...
- Mapping and isolation of the pulmonary veins using the PVAC catheterMattias Duytschaever
Department of Cardiology, St Jan Hospital Bruges, Ruddershove 10, Bruges, Belgium
Pacing Clin Electrophysiol 33:168-78. 2010..of the pulmonary vein ablation catheter (PVAC) catheter (a novel multielectrode catheter using duty-cycled bipolar and unipolar radiofrequency energy, Medtronic, Minneapolis, MN, USA) to completely isolate the pulmonary veins (PVs).
- Physiological consequences of bipolar radiofrequency energy on the atria and pulmonary veins: a chronic animal studySunil M Prasad
Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Ann Thorac Surg 76:836-41; discussion 841-2. 2003..This study examined the physiologic consequences of a novel energy source, bipolar radiofrequency energy, in a chronic animal model in order to determine its ability to produce transmural lesions on the beating heart...
- Totally endoscopic robotic-guided pulmonary veins ablation: an alternative method for the treatment of atrial fibrillationGino Gerosa
Istituto di Chirurgia Cardiovascolare, Universita degli Studi di Padova, 35128 Padova, Italy
Eur J Cardiothorac Surg 26:450-2. 2004In patients affected by isolated atrial fibrillation, epicardial pulmonary veins ablation can be performed with minimally invasive robotic-guided cardiac surgery techniques...
- Characterization of fractionated atrial electrograms critical for maintenance of atrial fibrillation: a randomized, controlled trial of ablation strategies (the CFAE AF trial)Ross J Hunter
Cardiology Department, Barts and The London NHS Trust QMUL, St Bartholomew s Hospital, London, United Kingdom
Circ Arrhythm Electrophysiol 4:622-9. 2011..This randomized study aimed to determine the effect of ablating different CFAE morphologies compared with normal electrograms (ie, debulking normal tissue) on the cycle length of persistent AF (AFCL)...
- Predictors of success after selective pulmonary vein isolation of arrhythmogenic pulmonary veins for treatment of atrial fibrillationEdward P Gerstenfeld
University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Heart Rhythm 3:165-70. 2006Atrial fibrillation (AF) ablation procedures typically involve isolation of all pulmonary veins (PVs) in addition to adjunctive linear lesions, yet the need for such an extensive ablation strategy in all patients is unclear.
- CARTO-guided vs. NavX-guided pulmonary vein antrum isolation and pulmonary vein antrum isolation performed without 3-D mapping: effect of the 3-D mapping system on procedure duration and fluoroscopy timeYaariv Khaykin
Heart Rhythm Program, Southlake Regional Health Centre, Newmarket, Ontario, Canada
J Interv Card Electrophysiol 30:233-40. 2011..This study examined the effect of two different mapping systems on the procedural characteristics and clinical outcomes of PVAI for atrial fibrillation...
- The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillationKunihiro Nishida
Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, 5000 Belanger Street, Montreal, QC, Canada H1T 1C8
Cardiovasc Res 89:825-33. 2011....
- Further evidence of a close anatomical relation between the oesophagus and pulmonary veinsGerold Mönnig
Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Str 33, 48149 Munster, Germany
Europace 7:540-5. 2005..Therefore, the position of the oesophagus in relation to the left atrium (LA) is of major importance for AF ablation...
- Relationship between arrhythmogenic pulmonary veins and the surrounding atrial substrate in patients with paroxysmal atrial fibrillationKazuyoshi Suenari
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
J Cardiovasc Electrophysiol 22:405-10. 2011The relationship between pulmonary veins (PVs) with atrial fibrillation (AF) initiating triggers and their surrounding atrial substrate has not been elucidated. We aimed to clarify the atrial substrate properties around the PVs.
- Identification and distribution of interstitial Cajal cells in human pulmonary veinsElodie Morel
Service de Rythmologie, Hopital Cardiologique Louis Pradel, Hospices Civils de Lyon, France
Heart Rhythm 5:1063-7. 2008..The major determinant of atrial fibrillation (AF) initiation is focal firing within the muscular portion of the pulmonary veins. We hypothesized that interstitial Cajal cells (ICCs), a known type of pacemaker cells, could underlie the ..
- High-density mapping of pulmonary veins and left atrium during ibutilide administration in a canine model of sustained atrial fibrillationChung Chuan Chou
Division of Cardiology, Department of Medicine, Rm 5537, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Am J Physiol Heart Circ Physiol 289:H2704-13. 2005..These findings suggest that the PV FD during AF is due to nonreentrant mechanisms. High doses of ibutilide may completely terminate all reentrant activity, converting AF to PV tachycardia before the resumption of sinus rhythm...
- Electrophysiology of pulmonary veinsYi Jen Chen
National Yang Ming University, School of Medicine, Division of Cardiology and Cardiovascular Research Center, Veterans General Hospital Taipei, Taipei, Taiwan
J Cardiovasc Electrophysiol 17:220-4. 2006b>Pulmonary veins were found to be important foci for the genesis and maintenance of atrial fibrillation...
- Correlation between anatomy and electrical activation in canine pulmonary veinsAkira Hamabe
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif 90048, USA
Circulation 107:1550-5. 2003The roles of complex muscle sleeve geometry and fiber orientation in the pulmonary veins (PVs) in wave-front propagation are poorly understood.
- Acute vagal modulation of electrophysiology of the atrial and pulmonary veins increases vulnerability to atrial fibrillationMario Oliveira
Unit of Autonomic Nervous System, Institute of Physiology, Faculty of Medicine of Lisbon, Av Prof Egas Moniz, Lisbon, Portugal
Exp Physiol 96:125-33. 2011..We evaluated the effects of acute vagal stimulation on atrial conduction, refractoriness of atrial and pulmonary veins (PVs) and inducibility of AF...
- Robot-assisted epicardial ablation of the pulmonary veins: is a completed isolation necessary?Thomas J van Brakel
Department of Cardiothoracic Surgery, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, P Debyelaan 25, Postbus 5800, 6202 AZ Maastricht, The Netherlands
Eur Heart J 26:1321-6. 2005To study the feasibility and electrophysiological efficacy of minimally invasive beating heart ablation of the pulmonary veins (PVs) via a robot-assisted single-sided approach.
- Intracellular calcium dynamics and anisotropic reentry in isolated canine pulmonary veins and left atriumChung Chuan Chou
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif 90048, USA
Circulation 111:2889-97. 2005Rapid activations due to either focal discharge or reentry are often present during atrial fibrillation (AF) in the pulmonary veins (PVs). The mechanisms of these rapid activations are unclear.
- Contractile and relaxant properties of rat-isolated pulmonary veins related to localization and histologyCécile Bronquard
Universite Francois Rabelais, CNRS UMR 6542, 31 Avenue Monge, 37200 Tours, France
Fundam Clin Pharmacol 21:55-65. 2007The aim of this study was to investigate the in vitro vasomotor properties of rat extra-and intralobar pulmonary veins (PVs) related to their localization and to assess the modulatory role of endothelium on these properties...
- Atrial fibrillation: multi-detector row CT of pulmonary vein anatomy prior to radiofrequency catheter ablation--initial experienceMonique R M Jongbloed
Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Radiology 234:702-9. 2005To evaluate multi-detector row computed tomographic (CT) depiction of pulmonary veins to provide a road map for radiofrequency catheter ablation.
- Development and structures of the venous pole of the heartRobert H Anderson
Cardiac Unit, Institute of Child Health, University College, London, United Kingdom
Dev Dyn 235:2-9. 2006..It gains its connection to the morphologically left atrium between the right- and left-sided systemic venous tributaries...
- Early morphogenesis of the sinuatrial region of the chick heart: a contribution to the understanding of the pathogenesis of direct pulmonary venous connections to the right atrium and atrial septal defects in hearts with right isomerism of the atrial appeJörg Männer
Department of Anatomy and Embryology, Georg August University, Gottingen, Germany
Anat Rec (Hoboken) 290:168-80. 2007..Our findings shed new light on the pathogenesis of direct pulmonary venous connections to the right atrium and atrial septal defects in hearts with right isomerism of the atrial appendages...
- [Unusual total anomalous pulmonary venous connection; report of a case]Kyokun Uehara
Department of Cardiovascular Surgery, Tenri Hospital, Tenri, Japan
Kyobu Geka 59:145-8. 2006..To the best of our knowledge, this is the first case where the vertical vein originated from right upper pulmonary vein. Immediate surgical treatment before the circuratory exacerbation improve the outcome for this congenital anomaly...
- Potassium channel diversity in the pulmonary arteries and pulmonary veins: implications for regulation of the pulmonary vasculature in health and during pulmonary hypertensionSebastien Bonnet
Department of Medicine Cardiology, University of Alberta, Edmonton, Canada
Pharmacol Ther 115:56-69. 2007..Understanding ionic diversity may allow development of therapies that locally increase K(+) channel current and expression to treat PHT...
- A novel cryoballoon technique for mapping and isolating pulmonary veins: a feasibility and efficacy studyMin Tang
Department of Internal Medicine Cardiology, German Heart Institute Berlin, Berlin, Germany
J Cardiovasc Electrophysiol 21:626-31. 2010....
- Endothelial damage and activation of the hemostatic system during radiofrequency catheter isolation of pulmonary veinsAlan Bulava
I Department of Medicine, University Hospital, Olomouc, Czech Republic
J Interv Card Electrophysiol 10:271-9. 2004To determine the systemic thrombogenic effect of radiofrequency catheter isolation of the pulmonary veins (PVI) in the treatment of atrial fibrillation.
- Partial anomalous pulmonary venous return: case report and review of the literatureJamil Anis AboulHosn
Harbor UCLA Medical Center, Torrance, California, USA
Catheter Cardiovasc Interv 58:548-52. 2003..Contrary to the expected obligatory drainage of highly saturated blood associated with APVR, lack of detectable shunting was thought to be due to the obstruction of regional blood due to thromboembolism...
- A difficult emergency surgical diagnosis: atresia of the common pulmonary veinO Dominguez Garcia
Hospital Virgen de la Salud, Toledo, Spain
Pediatr Cardiol 30:989-91. 2009..Subpleural and interstitial pulmonary lymphagiectasias also were present as well as evidence of pulmonary hypertension. The lung pathology probably resulted from pulmonary venous atresia during prenatal development...
- Disruption of Autonomic Pathways in Left Atrium by Inhibition of G ProteinsAlan H Kadish; Fiscal Year: 2010..In this regard, recent studies indicate an important role for the pulmonary veins and the posterior left atrium (PLA) in the genesis of this arrhythmia...
- Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic ReceptorsDAVID KEM; Fiscal Year: 2013..Our studies are directed toward establishing this association with atrial fibrillation and to develop future preventative measures and treatment. ..
- Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteinsRishi Arora; Fiscal Year: 2013..In this regard, recent studies indicate an important role for the pulmonary veins and the posterior left atrium (PLA) in the genesis of this arrhythmia...
- Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25PATRICK THOMAS ELLINOR; Fiscal Year: 2010..that has a critical role in determining left-right asymmetry, and the development of the left atrium and pulmonary veins. Ectopic electrical foci within the pulmonary veins initiates fibrillatory activity and is the target of ..
- Pathogenetics of the FOX transcription factor gene cluster on 16q24.1Pawel Stankiewicz; Fiscal Year: 2013DESCRIPTION (provided by applicant): Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a lethal neonatal diffuse developmental disorder of the lungs, which is commonly associated with multiple congenital ..
- Minimally Invasive Surgical Pulmonary Vein Insolation vs. Medical Management in PMICHAEL FARRIS WATERS; Fiscal Year: 2010..Literature in recent years has shown atrial fibrillation is often initiated by ectopic foci in the pulmonary veins and accordingly, there has been an explosion of catheter- based and minimally invasive surgical approaches to ..
- Comparative effectiveness of catheter ablation vs medical therapy for atrial fibrJames Freeman; Fiscal Year: 2013..ablation for atrial fibrillation (AF), using radiofrequency energy or cryotherapy to electrically isolate the pulmonary veins and eliminate arrhythmia foci, is a new therapy that is currently used to treat 50,000 patients per year in ..
- Impact of Atrial Fibrillation and Surgical Ablation on Atrial FunctionJASON OWEN ROBERTSON; Fiscal Year: 2012....
- The Role of Sema3D in Cardiac DevelopmentKarl Degenhardt; Fiscal Year: 2013..Moreover, the pulmonary veins are prone to stenosis, which frequently complicates the treatment of patients with TAPVR and other forms of ..
- The Contribution of Melanocyte-like Cells to Atrial Function and DevelopmentVickas V Patel; Fiscal Year: 2013DESCRIPTION (provided by applicant): We recently described a novel population of melanocyte-like cells in the pulmonary veins and atria of humans and mice...
- C-Arm CT for Guidence of Cardiac InterventionsRebecca Fahrig; Fiscal Year: 2010..One of our goals is to demonstrate the ability to depict the left atrium and pulmonary veins to provide guidance accuracy of better then 2 mm, and to reduce the time required for registration by 50% (~..
- Percutaneous cardiac HIFU ablation with multimodal image guidanceDouglas N Stephens; Fiscal Year: 2013..To treat the AF the most common anatomical target for ablation is the entrance of pulmonary veins and the surrounding tissue...
- Endovascular Cardiac Optical MappingChristian S Eversull; Fiscal Year: 2013....
- PROTOTYPE CATHETER FOR IN VIVO HIGH-RESOLUTION CARDIAC FLUORESCENCE MAPPINGMiguel Valderrabano; Fiscal Year: 2010....
- High-Speed Biplane X-Ray Fluoro/CT System for Translational Cardiovascular ResearMichael V McConnell; Fiscal Year: 2010..This funding will help support the jobs of Stanford researchers as well as the American jobs of the instrument company. It will also replace an older x-ray system with a more environmentally friendly system. ..
- Vein of Marshall Ethanol Infusion for Persistent Atrial FibrillationMiguel Valderrabano; Fiscal Year: 2013..PVAI)- can lead to cure, but is best suited for paroxysmal AF, in which ectopic beats arising from the pulmonary veins were shown to initiate AF...
- Real-time MRI-guided RF Ablation of Cardiac TachyArrhythmiasOrhan Unal; Fiscal Year: 2010..AF also accounts for 15% of all strokes. Ectopic electrical impulses originating in the pulmonary veins initiate AF in many patients...
- Mechanisms of Pulmonary Vein DevelopmentSteven B Bleyl; Fiscal Year: 2010..Thus, I will receive the necessary training both to direct an active research program and provide state-of-the-art clinical care. (End of Abstract) ..
- Cleveland Clinic Cardiothoracic Collaborative Clinical Center - C6Eugene Blackstone; Fiscal Year: 2013..End of Abstract) ..
- ENDOTHELIAL BIOLOGYRobert P Hebbel; Fiscal Year: 2011..The importance of these studies is that they well help us develop a novel therapy for sickle disease that will prevent the large stroke problem in affected kids. ..
- Novel Therapeutic Approaches to Atrial Fibrillation Targeting Intracellular CalciANDREW ROBERT MARKS; Fiscal Year: 2013..A rycal is now in Phase II clinical studies for heart failure and sudden cardiac death and would be available for testing in AF patients. ..
- INHIBITORY LEFT ATRIAL INFLUENCES ON THE BAROREFLEXDavid Ramsay; Fiscal Year: 1991..Thus it is anticipated that the essential role of the left atrium in hormonal and thirst responses to simulated hypovolemia will be established and that the mechanism of these interactions will be elucidated...
- Rapid High-Resolution Electroanatomical Cardiac Mapping System for the TreatmentDORON HARLEV; Fiscal Year: 2009..Superior mapping speed and accuracy would enable more targeted delivery of therapeutic ablative energy, thus improving both the safety and effectiveness of interventional procedures. ..
- A MODEL OF ATRIAL FIBRILATION TRIGGERSMark David Levin; Fiscal Year: 2013..Recent evidence demonstrates abnormal electrical activity from pulmonary veins (PV) initiates some types of AF...
- Semaphorin3d and anomalous pulmonary venous returnJonathan A Epstein; Fiscal Year: 2013..pulmonary venous return is a common form of congenital heart disease though little is known about how the pulmonary veins are normally patterned...
- SELECTIVE INNERVATION OF SA & AV NODAL REGIONS OF HEARTRobert Wurster; Fiscal Year: 1992Aggregates of postganglionic cell bodies are localized in the fat pads overlying the entrance of right pulmonary veins (PVFP) into the atrium and at the junction of inferior vena cava and inferior left atrium (IVC-ILA), excision of which ..
- INTRATHORACIC ARTIFICIAL LUNGSLYLE MOCKROS; Fiscal Year: 2000..PA) and outlet at the left atrium (parallel implantation), with banding of the distal pulmonary artery or pulmonary veins to divert flow from the natural lungs to the artificial lungs or placing the ITAL inlet at the proximal PA ..
- Cardiac Cryoablation CatheterRAN YARON; Fiscal Year: 2009..This project will help develop a device that will provide doctors a safer, simpler and lower cost procedure that will serve larger numbers of people suffering from this debilitating condition. ..
- RIGHT VENTRICULAR FUNCTIONWILLIAM SANTAMORE; Fiscal Year: 1991..Additionally, the information will help to explain the right ventricular response to ischemia and to pericardiotomy...
- Homogeneous Transfer of Connexin 43 to Prevent Atrial Fibrillation in PigsHao Qin; Fiscal Year: 2007..Ablation of rapidly depolarizing foci from pulmonary veins, although a practical solution for many drug resistant AF cases, is largely limited by the high rate of AF ..
- Electrophysiology of the pulmonary vein myocardium in AFJeffrey Olgin; Fiscal Year: 2006..has suggested that atrial fibrillation may be a result of focal activity from the atrial myocardium of the pulmonary veins. However, the mechanism of this form of atrial fibrillation is not known nor is the reason why there is a ..
- ASSESSMENT OF DIASTOLIC FUNCTION IN HUMANSJames Thomas; Fiscal Year: 1999....
- ANESTHESIA AND PULMONARY VASCULAR SIGNAL TRANSDUCTIONPaul Murray; Fiscal Year: 2006..general anesthetics on cellular mechanisms (cAMP, cGMP, K+ATP channel) that regulate vasodilator responses in pulmonary veins, including endothelium-dependent and PVSM components of the response...
- Role of Stretch in Focal Atrial FibrilationRishi Arora; Fiscal Year: 2007..to the animal lab, and has already done considerable work in understanding the electrophysiology of the pulmonary veins and their role in the genesis of atrial fibrillation (AF)...
- MYOSIN ISOFORM FUNCTION IN VASCULAR SMOOTH MUSCLEAnne Martin; Fiscal Year: 2003..These experiments will provide crucial information on the role of myosin isoforms in cardiovascular function in both physiological and pathological circumstances. ..
- PHOTONIC TREATMENT OF ATRIAL ARRHYTHMIAEDWARD SINOFSKY; Fiscal Year: 1999..of photonic energy; and design and test a newly conceived 'halo' shaped optical diffuser for ablation in pulmonary veins. PROPOSED COMMERCIAL APPLICATIONS: Atrial fibrillation is the most common sustained cardiac rhythm disorder ..
- Optical Coherence Tomography for Pulmonary CirculationMark Brezinski; Fiscal Year: 2005..been demonstrated that a significant portion of atrial fibrillation can be cured by ablation of foci in the pulmonary veins. However, this procedure is associated with a high incidence of pulmonary vein stenosis...
- A New Method For Discrimination of Tachycardia SitesGEORGE MELLMAN; Fiscal Year: 2004..We also note that if the method is successful, it may be possible to extend the results to more complicated arrhythmias and re-entrant events involving multiple entry points, or events obscured by other, larger phases. ..
- HEMODYNAMIC STUDY OF THE PULMONARY MICROCIRCULATIONJEN SHIH LEE; Fiscal Year: 1990..measure the density variation following an occlusion of the pulmonary artery or a partial occlusion of the pulmonary veins. This measurement provides a verification of the simulation and an assessment on the change in the pulmonary ..
- Positional mapping of a gene for Alveolar Capillary Dys*Bassem Bejjani; Fiscal Year: 2004..ACD is usually associated with misalignment or displacement of the pulmonary veins. The disease presents very early in infancy, usually after a few hours of normal breathing ("honeymoon period"..
- Visualizing the Substrate for Sudden Cardiac DeathVivek Reddy; Fiscal Year: 2006..abstract_text> ..
- Substrate Mapping & Ablation of Ventricular TachycardiaVivek Reddy; Fiscal Year: 2006..abstract_text> ..
- The Pathophysiology of T-wave AlternansSanjiv Narayan; Fiscal Year: 2005..This structured approach will ensure the successful completion of this project and, in this way, the development of the applicant into an independent clinician-investigator. ..
- VEGF PROTECTS AGAINST PULMONARY VASCULAR REMODELINGRubin Tuder; Fiscal Year: 2001....
- Towards a Non-Invasive Therapy for Atrial FibrillationBenjamin Scherlag; Fiscal Year: 2004..Recent clinical studies have suggested that trains of rapid electrical discharges from the pulmonary veins induce paroxysmal (P) or episodic AF. The mechanism by which this focal activity leads to PAF is unknown...
- Cardiac Arrhythmia MechanismsJOSE JALIFE; Fiscal Year: 2005....
- Endothelial Cell Death in EmphysemaRubin Tuder; Fiscal Year: 2007..abstract_text> ..
- ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITISDean Schraufnagel; Fiscal Year: 2003..abstract_text> ..
- Vasculature is a determinant of epithelial morphogenesisMARGARET SCHWARZ; Fiscal Year: 2006..Thus, identifying the factors responsible for coordinating vascular formation and distal lung morphogenesis will provide insight into the determinants by which their balance can affect lung development. ..
- DEVELOPMENTAL HEMATO-ENDOTHELIAL BIOLOGY OF P1H12Robert Hebbel; Fiscal Year: 2002..These studies represent a first step towards defining the role of P1H12 in embryology, with an emphasis on hematopoiesis and vasculogenesis (as rationalized by exciting preliminary data). ..
- NERVE SPROUTING AND ELECTRICAL REMODELINGPeng Sheng Chen; Fiscal Year: 2003..These studies may lead to novel insights into the mechanisms of ventricular arrhythmogenesis after MI and may help develop new methods for arrhythmia control. ..
- Role of IGF-1 In Diastolic Dysfunction of AgingLeanne Groban; Fiscal Year: 2003..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
- T-Lymphocyte role in Lung Ischemia-Reperfusion InjuryMary Townsley; Fiscal Year: 2004..The results of these studies will provide novel insight as to the role of lymphocytes in acute I/R-induced lung damage with the overall goal of improving success rates for clinical lung transplantation procedures. ..
- Oxidative Stress and Atrial FibrillationDAVID VAN WAGONER; Fiscal Year: 2004..We anticipate that these early interventions will prove to be the most effective approach to the long term treatment and prevention of AF. ..
- Role of Obscurin and Obscurin-MLCK in myofibrillogenesisMark Russell; Fiscal Year: 2008..Characterizing obscurin's roles in new myofibril assembly and in sarcomere-sarcoplasma organization may identify new strategies to treat congestive heart failure and prevent myofibril damage during ischemia. ..
- Tyrosine Phosphatases and Endothelial DysfunctionHua Tang; Fiscal Year: 2004..abstract_text> ..
- Mentored Patient-Oriented Research Career Development AwIVAN ROBBINS; Fiscal Year: 2004..These studies will advance our knowledge of the mechanism of action of epoprostenol and pulmonary hypertension. ..
- BOEC in BiologyRobert Hebbel; Fiscal Year: 2005..Aside from eventual therapeutics, these studies will define aspects of this unique cell type. ..
- TRPV4 in Regulation of Lung Endothelial PermeabilityMary Townsley; Fiscal Year: 2006..This work will provide the first rigorous analysis of compartmentalized TRPV4 channel expression linked to compartmentalized regulation of endothelial permeability in the intact lung. ..
- VASCULAR BED SPECIFIC EXPRESSION OF A VWF TRANSGENEWILLIAM AIRD; Fiscal Year: 2001..Taken together, these studies should provide important information about the mechanisms of endothelial cell heterogeneity and vascular diversity. ..