portal vein

Summary

Summary: A short thick vein formed by union of the superior mesenteric vein and the splenic vein.

Top Publications

  1. ncbi Complications of congenital portosystemic shunts in children: therapeutic options and outcomes
    Stephanie Franchi-Abella
    Radiologie Pédiatrique, Hopital Bicetre, APHP, Le Kremlin Bicetre, France
    J Pediatr Gastroenterol Nutr 51:322-30. 2010
  2. ncbi Radiotherapy plus transarterial chemoembolization for hepatocellular carcinoma invading the portal vein: long-term patient outcomes
    Sang Min Yoon
    Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 82:2004-11. 2012
  3. ncbi Detection of hepatic portal venous gas: its clinical impact and outcome
    Sebastian T Schindera
    Department of Diagnostic Radiology, University Hospital of Bern, Inselspital, 3010 Bern, Switzerland
    Emerg Radiol 12:164-70. 2006
  4. pmc Distinct effects of voltage- and store-dependent calcium influx on stretch-induced differentiation and growth in vascular smooth muscle
    Jingli Ren
    Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 285:31829-39. 2010
  5. ncbi Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall
    Sebastian Albinsson
    Vascular Physiology Group, Department of Experimental Medical Science, Lund University, BMC D12, Lund SE 221 84, Sweden
    Am J Physiol Cell Physiol 294:C271-9. 2008
  6. ncbi Transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein tumor thrombosis: a prospective comparative study
    Jun Luo
    Department of Hepatobiliary Oncology, Sun Yat Sen University, Guangzhou, People s Republic of China
    Ann Surg Oncol 18:413-20. 2011
  7. ncbi Portal vein thrombi after restorative proctocolectomy
    Feza H Remzi
    Departments of Colorectal Surgery Radiology and Biostatistics and Epidemiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Surgery 132:655-61; discussion 661-2. 2002
  8. ncbi Combined portal vein embolization and neoadjuvant chemotherapy as a treatment strategy for resectable hepatic colorectal metastases
    Anne M Covey
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 247:451-5. 2008
  9. ncbi Portomesenteric venous thrombosis after laparoscopic surgery: a systematic literature review
    Aaron W James
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0790, USA
    Arch Surg 144:520-6. 2009
  10. ncbi Portal vein entrance of splenic erythrocytic progenitor cells and local hypoxia of liver, two events cause intrahepatic splenosis
    Ching Ming Kwok
    Division of General Surgery, Department of Surgery, Cheng Hsin Rehabilitation Medical Center, No 45, Cheng Hsin Street, Taipei 112, Taiwan
    Med Hypotheses 67:1330-2. 2006

Detail Information

Publications358 found, 100 shown here

  1. ncbi Complications of congenital portosystemic shunts in children: therapeutic options and outcomes
    Stephanie Franchi-Abella
    Radiologie Pédiatrique, Hopital Bicetre, APHP, Le Kremlin Bicetre, France
    J Pediatr Gastroenterol Nutr 51:322-30. 2010
    ..Their management is controversial. The aim of this study was to propose a clear definition of the risks and management of congenital portosystemic shunts in children according to our experience and a review of the literature...
  2. ncbi Radiotherapy plus transarterial chemoembolization for hepatocellular carcinoma invading the portal vein: long-term patient outcomes
    Sang Min Yoon
    Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 82:2004-11. 2012
    We have evaluated the clinical outcomes of patients after transarterial chemoembolization (TACE) and 3-dimensional conformal radiotherapy for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT).
  3. ncbi Detection of hepatic portal venous gas: its clinical impact and outcome
    Sebastian T Schindera
    Department of Diagnostic Radiology, University Hospital of Bern, Inselspital, 3010 Bern, Switzerland
    Emerg Radiol 12:164-70. 2006
    ..CT is superior to CT scanograms and radiographs in the detection of HPVG and its underlying diseases and, therefore, should be used as the primary diagnostic tool...
  4. pmc Distinct effects of voltage- and store-dependent calcium influx on stretch-induced differentiation and growth in vascular smooth muscle
    Jingli Ren
    Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 285:31829-39. 2010
    ..Stretch-stimulated expression of contractile and cytoskeletal proteins in mouse portal vein was inhibited at mRNA and protein levels by blockade of voltage-dependent Ca(2+) entry (VDCE)...
  5. ncbi Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall
    Sebastian Albinsson
    Vascular Physiology Group, Department of Experimental Medical Science, Lund University, BMC D12, Lund SE 221 84, Sweden
    Am J Physiol Cell Physiol 294:C271-9. 2008
    ..In conclusion, caveolin 1 contributes to low basal ERK1/2 and Akt activity and is required for Akt-dependent signals in response to shear stress (flow) but is not essential for trophic effects of stretch (pressure) in the vascular wall...
  6. ncbi Transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein tumor thrombosis: a prospective comparative study
    Jun Luo
    Department of Hepatobiliary Oncology, Sun Yat Sen University, Guangzhou, People s Republic of China
    Ann Surg Oncol 18:413-20. 2011
    For patients with hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT), the survival benefit of transarterial chemoembolization (TACE) compared with conservative treatment largely remains controversial...
  7. ncbi Portal vein thrombi after restorative proctocolectomy
    Feza H Remzi
    Departments of Colorectal Surgery Radiology and Biostatistics and Epidemiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Surgery 132:655-61; discussion 661-2. 2002
    ..This study was undertaken to investigate the clinical presentation and implications of portal vein thrombi (PVT).
  8. ncbi Combined portal vein embolization and neoadjuvant chemotherapy as a treatment strategy for resectable hepatic colorectal metastases
    Anne M Covey
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 247:451-5. 2008
    The objectives of this study are 1) to determine whether the future liver remnant will grow after portal vein embolization (PVE) in patients with colon cancer on concurrent chemotherapy and 2) to determine whether recovery after extended ..
  9. ncbi Portomesenteric venous thrombosis after laparoscopic surgery: a systematic literature review
    Aaron W James
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0790, USA
    Arch Surg 144:520-6. 2009
    ....
  10. ncbi Portal vein entrance of splenic erythrocytic progenitor cells and local hypoxia of liver, two events cause intrahepatic splenosis
    Ching Ming Kwok
    Division of General Surgery, Department of Surgery, Cheng Hsin Rehabilitation Medical Center, No 45, Cheng Hsin Street, Taipei 112, Taiwan
    Med Hypotheses 67:1330-2. 2006
    ..that the two events caused the occurrence of the intrahepatic splenosis, the migration of the erythrocytic progenitor cells via the portal vein following traumatic splenic rupture, and the local induction of erythropoiesis by hypoxia.
  11. ncbi Comparison of the portal vein and kidney subcapsule as sites for primate islet autotransplantation
    Amer Rajab
    Department of Surgery, Division of Transplantation, The Ohio State University, Columbus, OH 43210, USA
    Cell Transplant 17:1015-23. 2008
    To date, the portal vein has been the primary site for clinical islet transplantation. Despite success, potential complications such as portal vein thrombosis still exist...
  12. ncbi Portal vein thrombi after ileal pouch-anal anastomosis: its incidence and association with pouchitis
    Chad G Ball
    Department of Surgery, Foothills Medical Centre, University of Calgary, 1403 29 Street N W, Calgary, AB, T2N 2T9, Canada
    Surg Today 37:552-7. 2007
    b>Portal vein thrombi (PVT) have recently been linked to ileal pouch-anal anastomosis (IPAA). We assessed the rate of PVT in patients who underwent IPAA and attempted to identify the associated features.
  13. pmc Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein
    Frank G van Steenbeek
    Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, PO Box 80154, 3508 TD Utrecht, The Netherlands
    Mamm Genome 23:76-84. 2012
    ..In both subtypes the development of the smaller branches of the portal vein tree in the liver is impaired and terminal branches delivering portal blood to the liver lobules are often ..
  14. ncbi Congenital extrahepatic portosystemic shunts (Abernethy malformation): a histopathologic evaluation
    Mikhail Lisovsky
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Am J Surg Pathol 35:1381-90. 2011
    ..Abernethy malformation may also be associated with hepatocellular carcinoma and focal nodular hyperplasia in some patients...
  15. ncbi Portal vein thrombosis and survival in patients with cirrhosis
    Michael J Englesbe
    Division of Transplantation, Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Liver Transpl 16:83-90. 2010
    The effects of occlusive portal vein thrombosis (PVT) on the survival of patients with cirrhosis are unknown. This was a retrospective cohort study at a single center. The main exposure variable was the presence of occlusive PVT...
  16. ncbi Interactions between apelin and angiotensin II on rat portal vein
    Bogdan Gurzu
    Faculty of Medicine, Department of Physiology, University of Medicine and Pharmacy Gr T Popa, 16 Universitatii Str, RO 700115 Iasi, Romania
    J Renin Angiotensin Aldosterone Syst 7:212-6. 2006
    ..The experiments were performed in endothelium-denuded or endothelium-intact rat portal vein in the presence of 10 microM N(G)-nitro L-arginine methyl ester or 10 microM aminoguanidine...
  17. ncbi Single center experience of 39 patients with preoperative portal vein thrombosis among 404 adult living donor liver transplantations
    Hiroto Egawa
    Organ Transplant Unit, Department of Transplant Surgery, Kyoto University Hospital, Kyoto, Japan
    Liver Transpl 12:1512-8. 2006
    Living donor liver transplantation (LDLT) for patients with portal vein thrombosis (PVT) involves technical difficulty...
  18. ncbi Major hepatic resection for hepatocellular carcinoma with or without portal vein embolization: Perioperative outcome and survival
    Martin Palavecino
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Surgery 145:399-405. 2009
    Preoperative portal vein embolization (PVE) is performed to minimize perioperative risks of major hepatic resection for hepatocellular carcinoma (HCC), but its effects on tumor growth are ill defined...
  19. ncbi Diagnostic value of Doppler assessment of the hepatic and portal vessels and ultrasound of the spleen in liver disease
    John O'Donohue
    Institute of Liver Studies, King s College Hospital, London, UK
    Eur J Gastroenterol Hepatol 16:147-55. 2004
    ....
  20. ncbi Pilot clinical trial of localized concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma with portal vein thrombosis
    Kwang Hyub Han
    Department of Internal Medicine, Yonsei Liver Cancer Special Clinic, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Cancer 113:995-1003. 2008
    Patients with advanced hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) have a particularly grave prognosis...
  21. ncbi Patency of stents covered with polytetrafluoroethylene in patients treated by transjugular intrahepatic portosystemic shunts: long-term results of a randomized multicentre study
    Christophe Bureau
    Federation Digestive Purpan, Service Hepato Gastro Enterologie CHU Toulouse, Toulouse, France
    Liver Int 27:742-7. 2007
    ..In patent shunts, the mean velocity within the portal vein was significantly higher but the performance of Doppler-US was not accurate enough to predict shunt dysfunction...
  22. pmc Selection criteria for hepatectomy in patients with hepatocellular carcinoma and portal vein tumor thrombus
    M Minagawa
    Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Ann Surg 233:379-84. 2001
    ..SUMMARY BACKGROUND DATA: The presence of portal vein tumor thrombus in a patient with hepatocellular carcinoma is one of the most significant factors for a poor ..
  23. ncbi Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?
    Niraj M Desai
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Transplantation 76:1623-5. 2003
    ..This protocol provided a unique opportunity to measure sirolimus and tacrolimus levels from the portal vein and compare them to systemic venous levels...
  24. ncbi Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis
    Laura M Kulik
    Department of Hepatology, Northwestern University, Chicago, IL, USA
    Hepatology 47:71-81. 2008
    ..data from a phase 2 study in which patients with unresectable hepatocellular carcinoma (HCC) with and without portal vein thrombosis underwent radioembolization with Yttrium ((90)Y) microspheres...
  25. ncbi Portal venous gas detected by computed tomography: is surgery imperative?
    David A Iannitti
    Department of Surgery, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02905, USA
    Dig Surg 20:306-15. 2003
    b>Portal vein gas (PVG) has historically been associated with mortality rates of 75% or higher and mandatory abdominal exploration...
  26. ncbi Meta-analysis: the significance of screening for JAK2V617F mutation in Budd-Chiari syndrome and portal venous system thrombosis
    X Qi
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 15 West Changle Road, Xi an, China
    Aliment Pharmacol Ther 33:1087-103. 2011
    ..However, the prevalence of JAK2V617F mutation in such patients is substantially varied, and its association with development of myeloproliferative disorders (MPD) is deficiently identified...
  27. pmc Comparison of coplanar and noncoplanar intensity-modulated radiation therapy and helical tomotherapy for hepatocellular carcinoma
    Chen Hsi Hsieh
    Department of Radiation Oncology, Mackay Memorial Hospital, and Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Radiat Oncol 5:40. 2010
    To compare the differences in dose-volume data among coplanar intensity modulated radiotherapy (IMRT), noncoplanar IMRT, and helical tomotherapy (HT) among patients with hepatocellular carcinoma (HCC) and portal vein thrombosis (PVT).
  28. ncbi Extensive mesenteric vein and portal vein thrombosis successfully treated by thrombolysis and anticoagulation
    A Tateishi
    Departments of Gastroenterology, Radiology and Surgical Oncology, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 16:1429-33. 2001
    ..Ultrasonography revealed moderate ascites, and there was minimal flow in the portal vein (PV) on the Doppler examination...
  29. ncbi Radiofrequency ablation of liver tumors: a new cause of benign portal venous gas
    Tamara Oei
    Department of Radiology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass, USA
    Radiology 237:709-17. 2005
    ..To retrospectively describe and categorize the presence of portal venous gas (PVG) from radiofrequency (RF) ablation of hepatic tumors...
  30. ncbi The epidemiology and clinical features of portal vein thrombosis: a multicentre study
    R Rajani
    Department of Medicine, Ryhov Hospital, Jonkoping, Sweden
    Aliment Pharmacol Ther 32:1154-62. 2010
    Reliable epidemiological data for portal vein thrombosis are lacking.
  31. ncbi Transcatheter arterial chemoembolization for hepatocellular carcinoma: anatomic and hemodynamic considerations in the hepatic artery and portal vein
    Kwang Hun Lee
    Department of Diagnostic Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea
    Radiographics 22:1077-91. 2002
    ..for evaluation of (a) the resectability and multiplicity of HCCs and (b) the hemodynamic status of the portal vein. Thereafter, TACE can be considered as the initial therapeutic modality...
  32. ncbi Portal vein thrombosis after laparoscopic splenectomy: the size of the risk
    Eduard M Targarona
    Service of General and Digestive Surgery, Hospital de Sant Pau, Autonomous University of Barcelona, Spain
    Surg Innov 15:266-70. 2008
    b>Portal vein thrombosis (PVT) after splenectomy is a potentially life-threatening complication. Clinical symptoms may be insidious, and progression can lead to intestinal infarction and portal hypertension...
  33. ncbi Trans-ileocecal portal vein embolization as a preoperative treatment for right trisegmentectomy with caudate lobectomy
    Tatsuo Shimura
    Department of General Surgical Science Surgery I, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Surg Oncol 96:438-41. 2007
    The indication of preoperative portal vein embolization (PVE) has been expanded to hepatocellular carcinoma, cholangiocellular carcinoma (CCC), hepatic metastasis, and gallbladder (GB) cancer as well as hilar cholangiocarcinoma (hCC)...
  34. ncbi Radiotherapy after transcatheter arterial chemoembolization for patients with hepatocellular carcinoma and portal vein tumor thrombus
    Satoshi Ishikura
    Radiation Oncology Division, National Cancer Center Hospital East, Kashiwa, Japan
    Am J Clin Oncol 25:189-93. 2002
    ..TACE) is used in the treatment of hepatocellular carcinoma; however, it has limited effect on portal vein tumor thrombus (PVTT)...
  35. ncbi Histopathological and immunohistochemical investigations of hepatic lesions associated with congenital portosystemic shunt in dogs
    S Baade
    Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    J Comp Pathol 134:80-90. 2006
    ..Postoperative biopsy samples showed basically the same lesions as those of pre-operative samples, except that signs of resolution of hepatic changes were apparent...
  36. ncbi Complete regression of locally advanced hepatocellular carcinoma induced by sorafenib allowing curative resection
    Sabine Irtan
    Department of HBP Surgery, Assistance Publique Hopitaux de Paris, University of Paris, Paris, France
    Liver Int 31:740-3. 2011
    We report two cases of locally advanced hepatocellular carcinoma (HCC) with portal vein tumour thrombosis (PVTT) who complete regression by sorafenib treatment allowed curative resection...
  37. ncbi Platelet administration via the portal vein promotes liver regeneration in rats after 70% hepatectomy
    Ryota Matsuo
    Department of Surgery, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    Ann Surg 253:759-63. 2011
    ..This study examines the applicability of platelet infusion therapy for liver regeneration in vivo...
  38. ncbi Value of carbon dioxide wedged venography and transvenous liver biopsy in the definitive diagnosis of Abernethy malformation
    B Collard
    Department of Radiology, University Hospital Gasthuisberg, Leuven, Belgium
    Abdom Imaging 31:315-9. 2006
    We report a 25-year-old man who presented with congenital absence of the portal vein, or Abernethy malformation, a rare congenital disorder in which the mesenteric and splenic venous drainages bypass the liver and directly drain into the ..
  39. ncbi Portal vein thrombosis, revisited
    Massimo Primignani
    IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Dig Liver Dis 42:163-70. 2010
    ..aims to discuss the aetiology, pathophysiology, clinical presentation, diagnostic workup and management of portal vein thrombosis, either as a primary vascular liver disease in adults and children, or as a complication of liver ..
  40. ncbi Increase in future remnant liver function after preoperative portal vein embolization
    W De Graaf
    Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands
    Br J Surg 98:825-34. 2011
    Preoperative portal vein embolization (PVE) is performed in patients with insufficient future remnant liver (FRL) to allow safe resection...
  41. ncbi Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis
    Lucio Amitrano
    Gastroenterology Unit, A Cardarelli Hospital, Naples, Italy
    J Clin Gastroenterol 44:448-51. 2010
    Treatment of portal vein thrombosis (PVT) in patients with liver cirrhosis is not well established.
  42. ncbi Chemotherapy does not impair hypertrophy of the left liver after right portal vein obstruction
    Diane Goere
    Department of HPB Surgery, Hospital Beaujon, 100 Boulevard du General Leclerc, 92118 Clichy, France
    J Gastrointest Surg 10:365-70. 2006
    ..by both reducing tumor volume with preoperative chemotherapy and by increasing the future remnant liver with portal vein embolization...
  43. ncbi CT depiction of portal vein thrombi after creation of ileal pouch-anal anastomosis
    Mark E Baker
    Department of Radiology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Radiology 227:73-9. 2003
    To determine the presence and location of portal vein thrombi in patients who have undergone ileal pouch-anal anastomosis (IPAA) and who were scanned with computed tomography (CT).
  44. pmc Hepatic artery and portal vein remodeling in rat liver: vascular response to selective cholangiocyte proliferation
    Tatyana V Masyuk
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 162:1175-82. 2003
    Three-dimensional reconstruction of the biliary tree, hepatic artery, and portal vein in normal rats and rats fed alpha-naphthylisothiocyanate (ANIT), a compound that causes selective proliferation of epithelial cells (ie, cholangiocytes)..
  45. ncbi Successful living donor liver transplant in a child with Abernethy malformation with biliary atresia, ventricular septal defect and intrapulmonary shunting
    Ashish Singhal
    Department of Surgical Gastroenterolgy and Liver Transplant, Indraprastha Apollo Hospital, New Delhi, India
    Pediatr Transplant 13:1041-7. 2009
    ..CEPSh has been extensively discussed and all the published cases of liver transplantation for CEPSh were reviewed...
  46. ncbi Doppler ultrasonographic assessment of closure of the ductus venosus in neonatal Irish wolfhounds
    C R Lamb
    Department of Veterinary Clinical Studies, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA
    Vet Rec 155:699-701. 2004
    ..which appeared as a parallel-sided or cone-shaped vessel connecting a left-sided intrahepatic branch of the portal vein with a confluence of veins on the cranial aspect of the liver...
  47. ncbi Right portal vein ligation: a new planned two-step all-surgical approach for complete resection of primary gastrointestinal tumors with multiple bilateral liver metastases
    Reza Kianmanesh
    Department of Hepato Biliary and Pancreas Surgery, Clichy, France
    J Am Coll Surg 197:164-70. 2003
  48. ncbi Pylephlebitis of the portal vein complicating intragastric migration of an adjustable gastric band
    Arnaud De Roover
    Department of Abdominal Surgery and Transplantation, University of Liege, Liege, Belgium
    Obes Surg 16:369-71. 2006
    Pylephlebitis, or septic thrombophlebitis of the portal vein, is an infrequent but life-threatening complication of abdominal septic events...
  49. ncbi Hypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons
    Satoshi Fujita
    Department of Kinesiology, University of Southern California, Los Angeles, California 90089, USA
    Am J Physiol Endocrinol Metab 293:E96-E101. 2007
    To elucidate the type of spinal afferent involved in hypoglycemic detection at the portal vein, we considered the potential role of capsaicin-sensitive primary sensory neurons...
  50. ncbi Branching morphology of the rat hepatic portal vein tree: a micro-CT study
    Jorn Op den Buijs
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Biomed Eng 34:1420-8. 2006
    ..The geometrical and fractal properties of the rat hepatic portal vein tree were investigated, with the aid of three-dimensional micro-computed tomography data...
  51. ncbi Portal vein thrombosis after intraportal hepatocytes transplantation in a liver transplant recipient
    Umberto Baccarani
    Department of Surgery and Transplantation Unit, University Hospital Udine, Udine, Italy
    Transpl Int 18:750-4. 2005
    ..Herein we report for the first time a case of portal vein thrombosis after intraportal hepatocytes transplantation in a liver transplant recipient...
  52. pmc Preoperative portal vein embolization for extended hepatectomy
    Alan W Hemming
    Department of Surgery, Center for Hepatobiliary Disease, University of Florida, Gainesville, FL 32610, USA
    Ann Surg 237:686-91; discussion 691-3. 2003
    To examine the authors' experience with preoperative ipsilateral portal vein embolization (PVE) and assess its role in extended hepatectomy.
  53. ncbi Epidemiologic factors associated with the anatomic location of intrahepatic portosystemic shunts in dogs
    Ursula Krotscheck
    Department of Small Animal Clinical Sciences, University of Florida, Gainesville, FL, USA
    Vet Surg 36:31-6. 2007
    ..To determine whether breed, sex, country of origin, and age are associated with anatomic location of intrahepatic portosystemic shunts (IHPSS) in dogs...
  54. ncbi Carnosine concentration of ingested meat affects carnosine net release into the portal vein of minipigs
    Caroline Bauchart
    UMR1019 Unité de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    J Nutr 137:589-93. 2007
    ..These results indicated that meat carnosine can be absorbed across the intestinal wall and that carnosine bioavailability depends on carnosine content of cooked meat...
  55. ncbi Influence of chemotherapy on liver regeneration induced by portal vein embolization or first hepatectomy of a staged procedure for colorectal liver metastases
    Kuniya Tanaka
    Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Gastrointest Surg 14:359-68. 2010
    Although portal vein embolization (PVE) and staged hepatectomy (StHx), as well as prehepatectomy chemotherapy, have improved the resectability rate of patients with multiple bilobar colorectal liver metastases, the impact of ..
  56. pmc Effect of portal vein embolisation on the growth rate of colorectal liver metastases
    V Pamecha
    Department of Hepato Pancreatico Biliary and Liver Transplant Surgery, Royal Free Hospital, University College London, London, UK
    Br J Cancer 100:617-22. 2009
    b>Portal vein embolisation (PVE) is used to increase the remnant liver volume before major liver resection for colorectal metastases. The resection rate after PVE is 60-70%, mainly limited by disease progression...
  57. ncbi Transcatheter arterial chemoembolization vs. chemoinfusion for unresectable hepatocellular carcinoma in patients with major portal vein thrombosis
    J H Kim
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Aliment Pharmacol Ther 29:1291-8. 2009
    ..TACE) has been limited in palliative treatment of unresectable hepatocellular carcinoma (HCC) with major portal vein (PV) invasion due to the possibility of liver failure following embolization...
  58. ncbi Induction of tumor growth after preoperative portal vein embolization: is it a real problem?
    Wilmar de Graaf
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Ann Surg Oncol 16:423-30. 2009
    Although preoperative portal vein embolization (PVE) is an effective means to increase future remnant liver (FRL) volume, little has been published on possible adverse effects...
  59. ncbi Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases
    Lorenzo Capussotti
    Divisione Chirurgia Oncologica, Istituto per la Ricerca e la Cura del Cancro, Strada Provinciale 142 km 3, 95, 10060 Candiolo, Italy
    Arch Surg 143:978-82; discussion 982. 2008
    To compare the volumetric increase of segments 2 and 3, segment 4, and the caudate lobe after portal vein ligation (PVL) and portal vein embolization (PVE)...
  60. pmc Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD
    Stuart G Beattie
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Hum Gene Ther 19:579-88. 2008
    ..hypothesized that these vectors would produce sufficient hepatocyte transduction (after administration via the portal vein) and thus sufficient SCAD enzyme to correct the phenotype observed in the SCAD-deficient (BALB/cByJ) mouse, ..
  61. ncbi Impact of portal vein embolization on long-term survival of patients with primarily unresectable colorectal liver metastases
    D A Wicherts
    Centre Hepato Biliaire, Assistance Publique Hopitaux de Paris, Hopital Paul Brousse, Villejuif, France
    Br J Surg 97:240-50. 2010
    b>Portal vein embolization (PVE) increases the resectability of initially unresectable colorectal liver metastases (CLM). This study evaluated long-term survival in patients with CLM who underwent hepatectomy following PVE.
  62. ncbi Congenital veno-venous malformations of the liver: widely variable clinical presentations
    Peter Witters
    Laboratory of Hepatology, Catholic University of Leuven, Leuven, Belgium
    J Gastroenterol Hepatol 23:e390-4. 2008
    ..However, their clinical presentation is less dependent on the anatomical type...
  63. pmc An aggressive approach leads to improved survival in hepatocellular carcinoma patients with portal vein tumor thrombus
    De Xin Lin
    The Hepatobiliary Division, Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical College, 325000 Wenzhou, China
    J Cancer Res Clin Oncol 137:139-49. 2011
    Many physicians express a relatively nihilistic approach to the treatment of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT)...
  64. ncbi Endovascular placement of iodine-125 seed strand and stent combined with chemoembolization for treatment of hepatocellular carcinoma with tumor thrombus in main portal vein
    Jianjun Luo
    Department of Radiology, Zhongshan Hospital, Fudan University, No 180 Fenglin Road, Shanghai, CN 200032, China
    J Vasc Interv Radiol 22:479-89. 2011
    To study the safety and feasibility of endovascular placement of an iodine-125 ((125)I) seed strand and stent combined with chemoembolization to treat hepatocellular carcinoma (HCC) with tumor thrombus in the main portal vein (MPV).
  65. ncbi Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival
    Goh Eun Chung
    Department of Internal Medicine, Gangnam Healthcare Center, Seoul National University Hospital, 28 Yungun Dong, Chongno Gu, Seoul 110 744, Korea
    Radiology 258:627-34. 2011
    To determine the efficacy and safety of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) and main portal vein (MPV) invasion.
  66. ncbi Captopril reduces portal pressure effectively in portal hypertensive patients with low portal venous velocity
    Soon Koo Baik
    Department of Internal Medicine, Wonju Christian Hospital, Yonsei University Wonju College of Medicine, 162 Ilsan dong, 220 701 Wonju, South Korea
    J Gastroenterol 38:1150-4. 2003
    ....
  67. pmc Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome
    Jennifer J Hofmann
    Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Development 137:4061-72. 2010
    ..Here, we report that Jag1 inactivation in the portal vein mesenchyme (PVM), but not in the endothelium of mice, leads to the hepatic defects associated with AGS...
  68. ncbi Management and classification of type II congenital portosystemic shunts
    Timothy B Lautz
    Department of Surgery, Children s Memorial Hospital, Feinberg School of Medicine of Northwestern University, Box 57, Chicago, IL 60614, USA
    J Pediatr Surg 46:308-14. 2011
    ..The indications for and benefits of repair of PSS remain incompletely understood. A more comprehensive classification may also benefit comparative analyses from different institutions...
  69. ncbi Management algorithm for pneumatosis intestinalis and portal venous gas: treatment and outcome of 88 consecutive cases
    Erik Wayne
    Department of Surgery, University of Louisville, Louisville, KY 40202, USA
    J Gastrointest Surg 14:437-48. 2010
    ..Computed tomography (CT) can identify PI/PVG in patients with ischemic emergencies and benign idiopathic conditions...
  70. ncbi Treatment of streptozotocin-induced diabetes mellitus by transplantation of islet cells plus bone marrow cells via portal vein in rats
    Kazuya Ikebukuro
    First Department of Pathology, Kansai Medical University, Osaka 570 8506, Japan
    Transplantation 73:512-8. 2002
    ..pancreatic islets (PIs) using sublethal irradiation (9 Gy) plus simultaneous transplantation of PIs and bone marrow cells (BMCs) via the portal vein (PV) followed by intravenous (i.v.) injection of donor BMCs (9 Gy + PV + i.v.).
  71. ncbi Review article: the modern management of portal vein thrombosis
    Y Chawla
    Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Aliment Pharmacol Ther 30:881-94. 2009
    b>Portal vein thrombosis (PVT) is an important cause of portal hypertension. It may occur as such with or without associated cirrhosis and hepatocellular carcinoma. Information on its management is scanty.
  72. pmc Relating function to branching geometry: a micro-CT study of the hepatic artery, portal vein, and biliary tree
    Timothy L Kline
    Department of Physiology and Biomedical Engineering, Physiological Imaging Research Laboratory, Mayo Clinic, College of Medicine, Rochester, Minn 55905, USA
    Cells Tissues Organs 194:431-42. 2011
    ..tomography images, the hierarchical structure, interbranch segment lengths and diameters of a hepatic artery, a portal vein, and two biliary trees from intact rat liver lobes were characterized...
  73. ncbi Mechanism of liver regeneration after liver resection and portal vein embolization (ligation) is different?
    Seiki Tashiro
    Tokushima University, Tokushima, Japan
    J Hepatobiliary Pancreat Surg 16:292-9. 2009
    ..b>Portal vein branch embolization and heat shock protein are then discussed...
  74. ncbi Portal vein thrombosis in a patient with HIV treated with a protease inhibitor-containing regimen
    P Soentjens
    Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Clin Belg 61:24-9. 2006
    ..episodes of haematemesis over time, caused by ruptured oesophageal varices as a consequence of a portal vein thrombosis...
  75. ncbi Air trapping: The major factor limiting diaphragm mobility in chronic obstructive pulmonary disease patients
    Wellington Pereira Dos Santos Yamaguti
    Department of Physical Therapy, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Respirology 13:138-44. 2008
    ..This study evaluated the relationship between pulmonary function and diaphragm mobility, as well as that between respiratory muscle strength and diaphragm mobility, in COPD patients...
  76. ncbi Management of portal vein thrombosis in liver transplantation: influence on morbidity and mortality
    Laura Llado
    Department of Surgery, Liver Transplant Unit, H U Bellvitge, University of Barcelona, Barcelona, Spain
    Clin Transplant 21:716-21. 2007
    Splanchnic thrombosis is a surgical challenge in liver transplantation (LT). The aim of this study was to analyze our experience in the management of portal vein thrombosis, and its influence on evolution.
  77. ncbi Reversibility of schistosomal periportal thickening/fibrosis after praziquantel therapy: a twenty-six month follow-up study in Ethiopia
    Nega Berhe
    Department of Infectious Diseases, Centre for Imported and Tropical Diseases, Ulleval University Hospital, Oslo, Norway
    Am J Trop Med Hyg 78:228-34. 2008
    ..Resolution of PPT/F was significantly more frequent at a younger age, among seronegative for hepatitis B virus and among those with a lower frequency of post-treatment recurrence of S. mansoni infections...
  78. ncbi Pulmonary hypertension in patients with congenital portosystemic venous shunt: a previously unrecognized association
    Takuro Ohno
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Pediatrics 121:e892-9. 2008
    ..However, the contribution of congenital anomalies occurring in the portal system to the development of pulmonary arterial hypertension remains to be elucidated...
  79. ncbi Effects of prophylactic splenic artery modulation on portal overperfusion and liver regeneration in small-for-size graft
    Yuzo Umeda
    Department of Gastroenterological Transplant Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, Okayama City, Okayama, Japan
    Transplantation 86:673-80. 2008
    ..Various approaches for portal decompression have been used, but details of their impact on liver regeneration in SFS graft remain unclear. We examined the effect of prophylactic splenic artery modulation (SAM)...
  80. ncbi Reappraisal of repeated transarterial chemoembolization in the treatment of hepatocellular carcinoma with portal vein invasion
    Kang Mo Kim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 24:806-14. 2009
    This study aimed to evaluate the therapeutic efficacy and safety of repeated transarterial chemoembolization (TACE) with additional radiation therapy (RT) in hepatocellular carcinoma (HCC) with portal vein (PV) invasion.
  81. ncbi Is there any difference in survival according to the portal tumor thrombectomy method in patients with hepatocellular carcinoma?
    Yosuke Inoue
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Surgery 145:9-19. 2009
    ..We describe a surgical technique in which the venous wall is peeled off from the PVTT...
  82. ncbi Hepatic portal venous gas: the ABCs of management
    Aaron L Nelson
    Tufts University School of Medicine, Boston, MA, USA
    Arch Surg 144:575-81; discussion 581. 2009
    ..While early studies were necessarily dependent on plain abdominal radiography, modern high-resolution CT has revealed a host of benign conditions in which HPVG has been reported that do not require emergent surgery...
  83. ncbi Prevalence of factor V Leiden mutation and other hereditary thrombophilic factors in Egyptian children with portal vein thrombosis: results of a single-center case-control study
    Hanaa El-Karaksy
    Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
    Ann Hematol 83:712-5. 2004
    No identifiable cause can be found in more than half of the cases of portal vein thrombosis (PVT)...
  84. pmc Etiology and portal vein thrombosis in Budd-Chiari syndrome
    Oguz Uskudar
    Yayla Mah 1 cadde no 123 3, Kecioren, Ankara 06010, Turkey
    World J Gastroenterol 14:2858-62. 2008
    To research the etiology, portal vein thrombosis and other features of Budd-Chiari syndrome (BCS) patients prospectively.
  85. ncbi Clinical and laboratory predictors of esophageal varices in children and adolescents with portal hypertension syndrome
    Eleonora Druve Tavares Fagundes
    Department of Pediatrics, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Pediatr Gastroenterol Nutr 46:178-83. 2008
    ..To determine the clinical and laboratory parameters that may predict the presence of esophageal varices in children and adolescents with portal hypertension...
  86. ncbi Factor V Leiden and prothrombin gene G20210A mutations are uncommon in portal vein thrombosis in India
    Sanjay Sharma
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Gastroenterol 25:236-9. 2006
    Extra-hepatic portal vein obstruction due to portal vein thrombosis (PVT) is an important cause of portal hypertension in several regions including India. The cause of thrombosis in these patients remains unclear...
  87. ncbi Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study
    Aurelie Plessier
    Service d Hepatologie, AP HP, Institut National de la Santé et de la Recherche Médicale U773 and Université Denis Diderot Paris 7, Hopital Beaujon, Clichy, France
    Hepatology 51:210-8. 2010
    Current recommendations for early anticoagulation in acute portal vein thrombosis unrelated to cirrhosis or malignancy are based on limited evidence...
  88. ncbi Portal vein thrombosis after hematopoietic cell transplantation: frequency, treatment and outcome
    K Kikuchi
    Gastroenterology Hepatology Section and the Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, and the University of Washington School of Medicine, Seattle, WA, USA
    Bone Marrow Transplant 29:329-33. 2002
    ..We reviewed the records of 1847 consecutive patients for evidence of portal vein thrombosis. Eight patients (0.4%) developed portal vein thrombosis (PVT) at a median of day +28 (range 3-58)...
  89. ncbi Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site
    Boaz Hirshberg
    National Institute of Diabetes and Digestive and Kidney Diseases Navy Transplantation and Autoimmunity Branch, NIH, Building 10 Rm 11S219, 10 Center Drive, Bethesda, MD 10889, USA
    Diabetes 51:2135-40. 2002
    ..would more safely and as effectively support long-term islet allograft survival compared with the traditional portal vein approach...
  90. ncbi A comparison of treatment combinations with and without radiotherapy for hepatocellular carcinoma with portal vein and/or inferior vena cava tumor thrombus
    Zhao Chong Zeng
    Radiation Oncology, Fudan University, Zhongshan Hospital, Shanghai 200032, China
    Int J Radiat Oncol Biol Phys 61:432-43. 2005
    To evaluate the potential role of external beam radiation therapy (EBRT) in the treatment of patients with hepatocellular carcinoma (HCC) who have portal vein (PV) and/or inferior vena cava (IVC) tumor thrombi.
  91. ncbi Risk factors for thrombophilia in extrahepatic portal vein obstruction
    Massimo Primignani
    Gastroenterology and Gastrointestinal Endoscopy Service, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milano, Milan, Italy
    Hepatology 41:603-8. 2005
    Scant information exists on the role of thrombophilia in extrahepatic portal vein obstruction (EHPVO)...
  92. ncbi Portal vein embolisation prior to hepatic resection for colorectal liver metastases and the effects of periprocedure chemotherapy
    I K Beal
    Department of Radiology, Royal Free Hospital NHS Trust and Royal Free, University College School of Medicine, London, UK
    Br J Radiol 79:473-8. 2006
    b>Portal vein embolisation (PVE) is an effective method of increasing future liver remnant (FLR) but may stimulate tumour growth. The effect of periprocedure chemotherapy has not been established...
  93. ncbi Improved diagnosis of hepatic perfusion disorders: value of hepatic arterial phase imaging during helical CT
    S Quiroga
    Department of Radiology and Institut de Diagnòstic per la Imatge, Hospital General Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Radiographics 21:65-81; questionnaire 288-94. 2001
    ..By recognizing these perfusion disorders, false-positive diagnosis (hypervascular tumors) or overestimation of the size of liver tumors (eg, hepatocellular carcinoma) can be avoided...
  94. ncbi Sequential preoperative arterial and portal venous embolizations in patients with hepatocellular carcinoma
    Taku Aoki
    Division of Hepato Biliary Pancreatic and Transplantation Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arch Surg 139:766-74. 2004
    ..Sequential, preoperative, selective transcatheter arterial chemoembolization (TACE) and portal vein embolization (PVE) allow feasible and safe major hepatic resections to be performed in HCC patients with ..
  95. pmc Differential regulation of Ca(2+)-activated Cl(-) currents in rabbit arterial and portal vein smooth muscle cells by Ca(2+)-calmodulin-dependent kinase
    I A Greenwood
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, UK
    J Physiol 534:395-408. 2001
    ..from smooth muscle cells isolated from rabbit pulmonary (PA) and coronary artery (CA) as well as rabbit portal vein (PV)...
  96. ncbi Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome
    D Ribero
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Br J Surg 94:1386-94. 2007
    This study evaluated the safety of portal vein embolization (PVE), its impact on future liver remnant (FLR) volume and regeneration, and subsequent effects on outcome after liver resection.
  97. ncbi Portal vein embolization and autologous CD133+ bone marrow stem cells for liver regeneration: initial experience
    Günter Fürst
    Institute of Diagnostic Radiology, Heinrich Heine University of Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany
    Radiology 243:171-9. 2007
    To prospectively evaluate the effectiveness of portal vein embolization (PVE) and CD133(+) bone marrow stem cell (BMSC) administration to the liver, compared with PVE alone, to augment hepatic regeneration in patients with large hepatic ..
  98. ncbi Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma
    Dae Yong Kim
    Research Institute and Hospital, National Cancer Center, Gyeonggi, Korea
    Cancer 103:2419-26. 2005
    b>Portal vein thrombosis (PVT) is a common complication in patients with advanced-stage hepatocellular carcinoma (HCC)...
  99. pmc Action of niflumic acid on evoked and spontaneous calcium-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein
    R C Hogg
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London
    Br J Pharmacol 112:977-84. 1994
    ..spontaneous and evoked calcium-activated chloride (ICl(Ca)) and potassium (IK(Ca)) currents in rabbit isolated portal vein cells. 2...
  100. ncbi Ultraselective transcatheter arterial chemoembolization with a 2-f tip microcatheter for small hepatocellular carcinomas: relationship between local tumor recurrence and visualization of the portal vein with iodized oil
    Shiro Miyayama
    Department of Diagnostic Radiology, Fukuiken Saiseikai Hospital, 7 1 Funabashi, Wadanaka cho, Fukui 918 8503, Japan
    J Vasc Interv Radiol 18:365-76. 2007
    To retrospectively evaluate the relationship between local tumor recurrence and iodized oil deposition in the portal vein by using ultraselective transcatheter arterial chemoembolization (TACE) for small hepatocellular carcinoma.
  101. ncbi A combination therapy with transarterial chemo-lipiodolization and systemic chemo-infusion for large extensive hepatocellular carcinoma invading portal vein in comparison with conservative management
    Jeong Won Jang
    Division of Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 505 Banpodong, Seocho Ku, 137 040, Seoul, South Korea
    Cancer Chemother Pharmacol 59:9-15. 2007
    Hepatocellular carcinoma (HCC) invading the portal vein is a medical challenge...

Research Grants63

  1. SMOOTH MUSCLE MYOSIN PHOSPHATASE SUBUNIT ISOFORMS
    Steven A Fisher; Fiscal Year: 2013
    ..E23 is spliced in smooth muscle tissues with fast (phasic) or intermediate contractile properties, e.g. portal vein and mesenteric resistance arteries, and skipped in the slow (tonic) smooth muscle of the large arteries and ..
  2. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..weeks before study catheters will be inserted under general anesthesia into the femoral artery, the hepatic portal vein and the hepatic vein, as well as in other vessels and sites as needed (splenic and jejunal veins, carotid and ..
  3. A Microfluidic-platform Mini-Liver System for Human Liver Biology Studies
    HONGSEOK M NOH; Fiscal Year: 2010
    ..The liver receives blood from the hepatic portal vein and the hepatic artery...
  4. Identifying a role for commensal bacteria on the liver immune priming environment
    Jean Publicover; Fiscal Year: 2013
    ..Additionally, blood from the mesenteric veins flows directly to the liver via the portal vein, allowing for the liver to be directly expose to bacterial products and potentially bacteria...
  5. Synergistic actions by multiple Toll-like receptors in alcoholic liver disease
    Ekihiro Seki; Fiscal Year: 2013
    ..intestinal permeability that leads to an elevation of endotoxin (lipopolysaccharide, LPS) levels in the portal vein. Increased endotoxin via the portal vein stimulates Kupffer cells through Toll-like receptor (TLR) 4, a ..
  6. Role of Bile Acids in the Initiation of Liver Regeneration
    Willscott E Naugler; Fiscal Year: 2013
    ..In Aim 2 a model of bile acid administration through the portal vein will allow the focused study of the effects of supraphysiolgic levels bile acids on the liver in the absence of ..
  7. The Role of Visceral Fatty Acids in Relation to Insulin Resistance
    Michelle T Foster; Fiscal Year: 2013
    ..Based on our preliminary data, we have hypothesized that excess FA flux to the liver via the hepatic portal vein is a key factor, and that it can occur for different reasons...
  8. Effect of Lactoferrin on Alcohol-Induced Dysbiosis and Gut Barrier Dysfunction
    Cynthia Ju; Fiscal Year: 2013
    ..intestines despite alcohol consumption, and as a result, lactoferrin prevents the transfer of endotoxin to the portal vein, reduces endotoxemia, and attenuates ALD...
  9. Regulatory B cells in the liver
    Susan K Bliss; Fiscal Year: 2010
    ..medications, and oral tolerance to dietary antigens can be abrogated by diversion of blood from the portal vein to the systemic circulation...
  10. REGULATION OF LIVER GROWTH AND FUNCTION
    Leonard S Jefferson; Fiscal Year: 2013
    ..to the gastrointestinal tract, affording it immediate access to the products of digestion appearing in the portal vein. The project also focuses on protein synthesis because the liver, in combination with the gastrointestinal ..
  11. PORPHYRIA AND HUMAN HEME BIOSYNTHESIS
    Robert J Desnick; Fiscal Year: 2010
    ..The optimally expressing vector(s) with envelope serotypes (1, 5, and 8) will be injected into the portal vein of the "AIP mice" and their ability to prevent phenobarbital-induced acute porphyric attacks will be monitored ..
  12. Characterization of Portal Vein Glucose Sensor Responsible for Satiety Control
    Chung Owyang; Fiscal Year: 2013
    ..Animal studies indicate that a decrease in portal vein glycemic level stimulates feeding and this is prevented by elevated glucose in the system...
  13. Noninvasive and Accurate Measurement of Portal Hypertension
    Flemming Forsberg; Fiscal Year: 2010
    Portal hypertension is defined as an increase in the pressure gradient between the portal vein and hepatic veins or the inferior vena cava (IVC)...
  14. Inhibition of Liver Macrophage activation in SIV infected macaques
    Donald L Sodora; Fiscal Year: 2013
    ..macrophages that will be the first to encounter any bacterial products that traverse the gut mucosa (via the portal vein), and the major focus of this proposal will be to investigate the potential for Kupffer cell dysfunction to ..
  15. Imaging for Y90 Microscphere SIRT Planning
    Anthony J McGoron; Fiscal Year: 2012
    ..liver tumors is from the hepatic artery while the majority of the blood supply to the normal liver is from the portal vein. The micro-vascular density of liver tumors is 3-200 times greater than the surrounding liver parenchyma ..
  16. Treg suppression of islet allograft rejection
    Ramakrishna Vankayalapati; Fiscal Year: 2013
    ..islet transplantation in the system resulted in even longer survival than that under kidney capsule or via the portal vein. We for the first time have selected the hepatic parenchyma as a grafting site based on the facts that the ..
  17. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2012
    ..of intestinal NH3/NH4+ transport are ill defined and poorly understood, this despite the well known impact of portal vein NH4+ concentration in the development of hyperammonemia in liver disease...
  18. Rectal Medication Administration Device for Palliative Care
    BRADFORD MACY; Fiscal Year: 2013
    ..evolved for rapid and effective absorption, and the distal 1/3 of the rectum partially bypasses the hepatic portal vein allowing medication to enter the central venous system without a first pass effect through the liver...
  19. ENDOSCOPIC BIOPSY OF ISLET TRANSPLANTS IN THE GASTRIC SUBMUCOSAL SPACE IN PIGS
    Hidetaka Hara; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The allotransplantation (Tx) of deceased human donor islets into the portal vein (PV) in patients with type 1 diabetes has been followed by encouraging results...
  20. Role of the Liver in Microbial Translocation and AIDS Pathogenesis
    Andrew A Lackner; Fiscal Year: 2012
    ..In order to test this hypothesis we propose the following three specific aims that will utilize indwelling portal vein catheters in rhesus macaques that are: i) uninfected, ii) infected with pathogenic SIVmac239, or iii) infected ..
  21. Relevance of the Route of Insulin Delivery to the Develpment of Hypoglycemia
    JUSTIN GREGORY; Fiscal Year: 2013
    ..The proposed research will test the hypothesis that delivery of insulin into the portal vein, as opposed to a peripheral vein, reduces hypoglycemic exposure in a canine model utilizing two approaches...
  22. Innate immunity in clinical islet transplantation: a clinical study (CIT0-01) in
    Olle Korsgren; Fiscal Year: 2012
    ..At the time of transplantation, the isolated islets are allowed to embolize the liver after infusion in the portal vein, a procedure that is unique in the area of transplantation...
  23. FORMATION AND METABOLISM OF NITROSAMINES IN PIGS
    Peter Magee; Fiscal Year: 1991
    ..The non-radioactive or labeled compound will be given by the oral and intravenous routes and directly into the portal vein by single or repeated injections or by continued infusion...
  24. Bioengineering a Chimeric Human Lung
    Gordana Vunjak-Novakovic; Fiscal Year: 2013
    ..simultaneously perfusing decellularization fluids through the lung parenchyma and Perfadex solution through the portal vein, we will preserve intact lung vasculature...
  25. CLOSTRIDIUM DIFFICILE INFECTION
    JERGANG CHANG; Fiscal Year: 1991
    ..And finally for specific aim 4, hamsters will be injected intracecally and intravenously (portal vein) of both exotoxins to produce the typical lesions in the ceca and to answer the question of the relationship ..
  26. UPPER GI TRACT MEDIATION OF THE SATIETY EFFECT OF FATS
    Danielle Greenberg; Fiscal Year: 1992
    ..by measuring triglyceride levels in the blood subsequent to infusions, infusing fats into the hepatic-portal vein or the inferior vena cava, on confing fats in the stomach, of sham and real feeding rats...
  27. DETERMINANTS OF SODIUM RETENTION IN CIRRHOSIS
    WILLIAM RECTOR; Fiscal Year: 1992
    ..Total BV eventually returns to normal or even becomes elevated owing to expansion of the volume of blood in the portal vein and inferior vena cava...
  28. HORMONAL CONTROL OF GROWTH
    CHARLES NICOLL; Fiscal Year: 1992
    ..and corticosterone) on hepatic secretion of IGF-I in vivo will be determined by infusing them into the hepatic portal vein of Hx rats...
  29. CONTROL OF FEEDING BEHAVIOR--HEPATIC AFFERENT SIGNALING
    CHARLES HORN; Fiscal Year: 2002
    ..In the current project 2,5-AM and MA will be infused into the portal vein to isolate the treatments to the liver, while electrophysiological recordings are done from the vagus nerve and ..
  30. Liver Regeneration in Man--Effects or Adjuvant Therapy
    Yuman Fong; Fiscal Year: 2005
    ..Two new advances that are reaching clinical testing and utilization are 1) pre-operative unilateral portal vein embolization as a means of producing contralateral liver hypertrophy to extend the possibilities of resective ..
  31. IMMUNOMODULATORY ROLE OF HCV CORE ON AUTOIMMUNE HEPATITI
    YOUNG HAHN; Fiscal Year: 2001
    ..Strikingly, in parallel to autoimmune hepatitis, massive lymphocytic infiltration was noted around the portal vein of liver in CD2/core transgenic mice and these intrahepatic lymphocytes were associated with liver injury...
  32. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..unchanged parent BaP in mesenteric lymph, portal vein blood, liver, and bile in wild-type and all seven Cyp1 knockout mouse lines, and the role and mechanism of ..
  33. REGULATION OF RENAL K+ EXCRETION BY GUT FACTOR
    JANG YOUN; Fiscal Year: 2009
    ..e., jugular vein, hepatic portal vein, and stomach)...
  34. Vascular Response to Hemmorhage in Portal Hyprtension
    JAMES SITZMANN; Fiscal Year: 2006
    ..We will use in vivo models of PHT with and without cirrhosis (bile duct ligated [BDL] and partial portal vein ligated [PVL]) in wild type and iNOS, eNOS, COX 1, COX 2 knockout mice, in conjunction with in vitro models of ..
  35. Cell Volume Regulated Biology in the Liver
    Ravi Chari; Fiscal Year: 2005
    ..Rats undergoing 2/3 partial hepatectomy will have concomitant infusion of agents through the portal vein. Changes in PI3K and MAPKinase signal cascades activation and alterations in cell cytoskeleton will be ..
  36. PHOSPHOLAMBAN MODULATION OF SMOOTH MUSCLE CONTRACTILITY
    Richard Paul; Fiscal Year: 2000
    ..The initial studies will focus on the tonic aorta and the phasic portal vein as representative vascular preparations and the longitudinal ileum and trachea preparations, representative of ..
  37. Recovery /preservation of donation cardiac death livers
    Mark Clemens; Fiscal Year: 2006
    ..The scale-up system will include oxygenation and dual flow controlled perfusion to the portal vein and hepatic artery to improve flow homogeneity...
  38. HEPATIC MECHANISM FOR CONTROL OF FOOD INTAKE
    Mark Friedman; Fiscal Year: 2003
    ..1) the difference in glucose concentration in the blood vessels supplying the liver (hepatic artery and hepatic portal vein) generates a satiety signal; 2) the sensory neurons in the vagus nerves mediate the satiating effect of high ..
  39. ASSESSMENT OF INTRAPORTAL HEPATOCYTE TRANSPLANTATION
    GEOFFREY BUDD; Fiscal Year: 1980
    ..Gunn rats and Wistar rats; they will be radioactively labeled in vivo or in vitro and transplanted via the portal vein into the liver of homozygous, jaundiced Gunn rats...
  40. NEUROBEHAVIORAL ANALYSIS OF GLUCAGON SATIETY
    NORCROSS GEARY; Fiscal Year: 2000
    ..Aim 2 is to compare hepatic portal vein and hepatic vein plasma glucagon levels during nocturnal spontaneous meals in undisturbed rats with those ..
  41. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..HCC frequently spreads to distant organs, including the portal vein, lymph nodes, and lungs, resulting in the demise of the patient...
  42. MOLECULAR AND CELLULAR MECHANISMS OF ALD
    ELEANOR METCALF; Fiscal Year: 1999
    ..bacteria] translocation and release of endotoxin (LPS) derived from these bacteria into the liver via the portal vein. Although the exact mechanisms of liver injury in ALD are currently unclear, reports have suggested that ..
  43. PTH RELATED PROTEIN IN VASCULAR SMOOTH MUSCLE
    Thomas Clemens; Fiscal Year: 2004
    ..Studies will be performed in isolated aortic and portal vein preparations to determine probe specific mechanisms by which PTHrP alters vascular tone...
  44. FLOW VELOCITY QUANTITATION BY MRI
    David Saloner; Fiscal Year: 1993
    ..disease, peripheral vascular disease, cardiac valve stenosis and regurgitation, aneurysms, A-V shunts, and portal vein abnormalities. However, many vessels of interest are not accessible to ultrasound or show poor reproducibility...
  45. Roles of bacterial flora in endotoxin shock mediated vi*
    Koichi Kobayashi; Fiscal Year: 2006
    ..LPS produced by commensal bacterial flora in the intestine is actually observed in blood circulation in the portal vein in laboratory animals, it is conceivable that commensal bacterial flora simulate the immune system, leading to ..
  46. GLUCOSE HOMEOSTASIS AND THE SURGICALLY ALTERED PANCREAS
    JOHN HANKS; Fiscal Year: 1990
    ..further studies that allow more sophisticated analysis of hepatic glucose output after "de-insulination" of the portal vein. The response of decreased beta cell mass to sulfonylurea treatment will be studied...
  47. 3D Image Guided Endovascular Surgery
    Elizabeth Bullitt; Fiscal Year: 2006
    ..DSA), 3) Development of fast, real-time tracking methods to detect changes in the position of the target portal vein resulting from patient respiration or needle pressure on the liver during the procedure, 4) 3D reconstruction ..
  48. Delivery of a Myostatin Inhibitor by AAV Gene Therapy for Muscular Dystrophy
    AMANDA HAIDET; Fiscal Year: 2009
    ..delivery method of an AAV vector encoding a secreted myostatin inhibitor by comparing intramuscular versus portal vein delivery in a mouse model of DMD, the dystrophin deficient mdx mouse...
  49. ROLE OF SENSING OF K+ INTAKE IN K+ HOMEOSTASIS
    JANG YOUN; Fiscal Year: 2005
    ..The objective of this project is to test the hypothesis that K+ intake is sensed by K+ sensors in the portal vein, and both renal K+ excretion and extrarenal cellular K+ uptake are regulated by this signal...
  50. REGIONAL CHEMOTHERAPY OF LIVER METASTASIS--COLON CANCER
    Joseph Bertino; Fiscal Year: 1991
    ..are to improve the local control of hepatic metastasis of colorectal carcinoma through intra-arterial or portal vein chemotherapy...
  51. CONTRACTION OF VASCULAR SMOOTH MUSCLE CELLS
    KATHLEEN MORGAN; Fiscal Year: 2004
    ..the use of multicellular strips, freshly, enzymatically isolated single cells from ferret aorta and ferret portal vein and purified proteins...
  52. KINASE REGULATION OF L TYPE CALCIUM CHANNELS
    Kathleen Keef; Fiscal Year: 2002
    ..The present study investigates kinase regulation of Ca(L) channels in smooth muscle cells of the rabbit portal vein. Experiments are described to investigate the role of G-protein subunits, anchoring proteins, phosphodiesterase ..
  53. PORTAL GLUCOSENSORS IN HYPOGLYCEMIC DETECTION
    CASEY DONOVAN; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): This proposal focuses on portal vein gluocosensors...
  54. INTESTINAL TRANSPLANTATION IN INBRED RATS
    SUE ODORISIO; Fiscal Year: 1992
    ..term immunosuppression, by means of two new approaches to recipient pretreatment: enteral administration and portal vein injection of donor type cells combined with short-term cyclosporine...
  55. TUMOR NECROSIS FACTOR AND PORTAL HYPERTENSION
    Matthew Metz; Fiscal Year: 2003
    ..In vivo models of PHT (portal vein ligation, PVL) in wildtype and TNF-a, iNOS, eNOS, COX-l, COXII knockout mice, in conjunction with in vitro co-..
  56. LYMPHATIC DELIVERY OF INTERLEUKIN-2
    LINNAR TENG; Fiscal Year: 1992
    ..to modify IL-2 by rendering it more a) lipophilic b) resistant to acid hydrolysis and c) able to circumvent portal vein absorption...
  57. MODIFICATION OF THE IMMUNE RESPONSE BY THE LIVER
    M Flye; Fiscal Year: 1999
    ..In addition, pretransplant antigen administration via the portal vein prolongs allograft survival, presumably by processing of the antigen through the liver by an undefined ..
  58. GROWTH FACTORS IN VASCULAR SMOOTH MUSCLE
    Thomas Doetschman; Fiscal Year: 2000
    ..and contractile function of vascular smooth muscle cells in major vessels, including aorta, carotid artery, portal vein, and mesenteric resistance artery, as well as in the response of aorta and carotid artery VSM to hypertension ..
  59. NA-PUMP ISOFORM-SPECIFIC REGULATION OF VASCULAR FUNCTION
    Richard Paul; Fiscal Year: 2004
    ..Our hypothesis is that contractility is strongly affected by the a2 isoform. Contractility in aorta, portal vein and resistance vessels will be compared to cardiovascular parameters in the whole animal. Specific Aim 2...
  60. Liver to Endocrine Pancreas Transdifferentiation
    Lijun Yang; Fiscal Year: 2009
    ..transdifferentiation of liver cells into IPCs in mice using a hydrodynamic-based tail vein delivery system, portal vein infusion, or direct intrahepatic injection...
  61. VEGF Promotes Pancreatic Tumor Cell Arrest in the Liver
    Jason Fleming; Fiscal Year: 2005
    ..to the liver describe a very inefficient process in which most cells that embolize to hepatic sinusoids via the portal vein do not develop into metastatic tumors...
  62. Carbohydrate Metabolism in Late Pregnancy
    Mary Moore; Fiscal Year: 2005
    ..Preliminary studies in the pregnant dog model in fact suggest that multiple counterregulatory mechanisms are altered by pregnancy. ..
  63. Pathophysiological Interpretations of Dynamic PET/CT of Molecular Liver Biology
    Susanne Keiding; Fiscal Year: 2010
    ..Models for determining tracer input from the portal vein and the hepatic artery (dual input function) and microcirculation of the liver are investigated with 11 CO-PET ..