veins

Summary

Summary: The vessels carrying blood toward the heart.

Top Publications

  1. ncbi Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors
    Takami Yurugi-Kobayashi
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507 Japan
    Arterioscler Thromb Vasc Biol 26:1977-84. 2006
  2. doi Sox18 induces development of the lymphatic vasculature in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 456:643-7. 2008
  3. pmc Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
    R Sathish Srinivasan
    Department of Genetics and Tumor Cell Biology, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 21:2422-32. 2007
  4. pmc Finger vein recognition using local line binary pattern
    Bakhtiar Affendi Rosdi
    Intelligent Biometric Group, School of Electrical and Electronic Engineering, USM Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Seberang Perai Selatan, Pulau Pinang, Malaysia
    Sensors (Basel) 11:11357-71. 2011
  5. pmc Mechanisms of vein graft adaptation to the arterial circulation: insights into the neointimal algorithm and management strategies
    Akihito Muto
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    Circ J 74:1501-12. 2010
  6. ncbi Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes
    J L Gomez-Skarmeta
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    Cell 85:95-105. 1996
  7. pmc Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment
    Maria Jelinic
    2Department of Zoology, The University of Melbourne, Parkville, Vic, 3010, Australia
    FASEB J 28:275-87. 2014
  8. ncbi Spatial heterogeneity in VEGF-induced vasodilation: VEGF dilates microvessels but not epicardial and systemic arteries and veins
    Roger J Laham
    Angiogenesis Research Center, Department of Medicine and Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Vasc Surg 17:245-52. 2003
  9. pmc Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
    R Sathish Srinivasan
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 25:2187-97. 2011
  10. doi Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Dev Biol 364:89-98. 2012

Detail Information

Publications393 found, 100 shown here

  1. ncbi Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors
    Takami Yurugi-Kobayashi
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507 Japan
    Arterioscler Thromb Vasc Biol 26:1977-84. 2006
    ..In this study, we constructively induced differentiation of arterial and venous endothelial cells (ECs) in vitro to elucidate molecular mechanisms of arterial-venous specification...
  2. doi Sox18 induces development of the lymphatic vasculature in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 456:643-7. 2008
    ..Our findings demonstrate a critical role for Sox18 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies...
  3. pmc Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
    R Sathish Srinivasan
    Department of Genetics and Tumor Cell Biology, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 21:2422-32. 2007
    ..We conclude that the mammalian lymphatic system has a solely venous origin...
  4. pmc Finger vein recognition using local line binary pattern
    Bakhtiar Affendi Rosdi
    Intelligent Biometric Group, School of Electrical and Electronic Engineering, USM Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Seberang Perai Selatan, Pulau Pinang, Malaysia
    Sensors (Basel) 11:11357-71. 2011
    ..Experimental results show that the proposed method using LLBP has better performance than the previous methods using LBP and local derivative pattern (LDP)...
  5. pmc Mechanisms of vein graft adaptation to the arterial circulation: insights into the neointimal algorithm and management strategies
    Akihito Muto
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    Circ J 74:1501-12. 2010
    ..Scientific inquiry into venous-specific adaptation mechanisms will ultimately provide improvements in vein graft clinical outcomes...
  6. ncbi Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes
    J L Gomez-Skarmeta
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    Cell 85:95-105. 1996
    ..veinlet) are expressed in highly resolved patterns that prefigure the positions of sensory organs and wing veins, respectively...
  7. pmc Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment
    Maria Jelinic
    2Department of Zoology, The University of Melbourne, Parkville, Vic, 3010, Australia
    FASEB J 28:275-87. 2014
    ..This study first aimed to localize RXFP1 in rat arteries and veins from different organ beds and determine whether receptors are present in endothelial cells...
  8. ncbi Spatial heterogeneity in VEGF-induced vasodilation: VEGF dilates microvessels but not epicardial and systemic arteries and veins
    Roger J Laham
    Angiogenesis Research Center, Department of Medicine and Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Vasc Surg 17:245-52. 2003
    ..that was partially inhibited by L-NNA, but had no effect on epicardial coronary arteries, systemic arteries, or veins. Both VEGF receptors (flt-1 and flk-1) were identified on endothelial cells of epicardial arteries and veins...
  9. pmc Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
    R Sathish Srinivasan
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 25:2187-97. 2011
    Arteries, veins, and lymphatic vessels are functionally linked, and their physical interaction is tightly regulated. The lymphatic vessels communicate with the blood vessels only at the junction of the jugular and subclavian veins...
  10. doi Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Dev Biol 364:89-98. 2012
    During lymphangiogenesis in the mammalian embryo, a subset of vascular endothelial cells in the cardinal veins is reprogrammed to adopt a lymphatic endothelial fate...
  11. ncbi Physiological regulation of penile arteries and veins
    D Prieto
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Int J Impot Res 20:17-29. 2008
    ..nerves maintain flaccidity and tonically released noradrenaline induces vasoconstriction of both arteries and veins through alpha(1)- and alpha(2)-postsynaptic receptors and downregulates its own release and that of nitric oxide (..
  12. pmc The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells
    Mirko Corselli
    Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, UCLA and Orthopaedic Hospital, Los Angeles, California 90095, USA
    Stem Cells Dev 21:1299-308. 2012
    ..In conclusion, we demonstrate the co-existence of 2 separate perivascular MSC progenitors: pericytes in capillaries and microvessels and adventitial cells around larger vessels...
  13. pmc Convergence of Notch and beta-catenin signaling induces arterial fate in vascular progenitors
    Kohei Yamamizu
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Cell Biol 189:325-38. 2010
    ..This molecular machinery for arterial specification leads to an integrated and more comprehensive understanding of vascular signaling...
  14. ncbi Intraoperative varicocele anatomy: a microscopic study of the inguinal versus subinguinal approach
    Carin V Hopps
    Center for Male Reproductive Medicine and Microsurgery, Cornell Institute for Reproductive Medicine, The New York Weill Cornell Medical Center, New York 10021, USA
    J Urol 170:2366-70. 2003
    ..We describe the number and relationship of internal and external spermatic arteries, veins and lymphatics within the subinguinal portion of the spermatic cord in infertile men undergoing microscopic ..
  15. ncbi Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity
    Li Ru You
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 435:98-104. 2005
    Arteries and veins are anatomically, functionally and molecularly distinct...
  16. ncbi Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
    H U Wang
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 93:741-53. 1998
    The vertebrate circulatory system is composed of arteries and veins. The functional and pathological differences between these vessels have been assumed to reflect physiological differences such as oxygenation and blood pressure...
  17. ncbi Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo
    K Bhagat
    Centre for Clinical Pharmacology, Cruciform Project for Strategic Medical Research and Department of Medicine, University College London, UK
    Circulation 96:3042-7. 1997
    ..Endothelial dysfunction occurs in many diseases associated with increased cardiovascular risk. We examined the effects of pro-inflammatory cytokines on endothelial function...
  18. doi The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling
    Monica Corada
    IFOM, The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Dev Cell 18:938-49. 2010
    ..We propose that early and sustained beta-catenin signaling prevents correct endothelial cell differentiation, altering vascular remodeling and arteriovenous specification...
  19. ncbi Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:1919-28. 1997
    The veins in the Drosophila wing have a characteristic width, which is regulated by the activity of the Notch pathway...
  20. ncbi Pooling in chronic orthostatic intolerance: arterial vasoconstrictive but not venous compliance defects
    Julian M Stewart
    Department of Pediatrics and Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circulation 105:2274-81. 2002
    ..My colleagues and I tested the hypothesis that pooling results from increased venous compliance in POTS patients...
  21. doi Fluid shear stress induces arterial differentiation of endothelial progenitor cells
    Syotaro Obi
    Department of Biomedical Engineering, University of Tokyo, Tokyo 113 0033, Japan
    J Appl Physiol (1985) 106:203-11. 2009
    ..These results indicate that shear stress induces differentiation of EPCs into arterial endothelial cells by increasing ephrinB2 expression in EPCs through Sp1 activation...
  22. doi Extracranial venous drainage patterns in patients with multiple sclerosis and healthy controls
    R A McTaggart
    Department of Radiology, Stanford University, Stanford University Medical Center, Stanford, CA 94305, USA
    AJNR Am J Neuroradiol 33:1615-20. 2012
    ..Our purpose was to evaluate possible differences in the extracranial venous drainage of MS and healthy controls using both TOF and contrast-enhanced TRICKS MRV...
  23. doi Direct venous spinal reabsorption of cerebrospinal fluid: a new concept with serial magnetic resonance cisternography in rabbits
    Huseyin Biceroglu
    Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Neurosurg Spine 16:394-401. 2012
    ..Huge absorptive surface areas of microvessels have been suggested to serve a putative role in reabsorption. The authors' aim was to observe direct venous connections between the subarachnoid space and the perispinal veins.
  24. doi Vascular reconstruction during pancreatoduodenectomy for ductal adenocarcinoma of the pancreas improves resectability but does not achieve cure
    Mehdi Ouaissi
    Division of Hepato Biliary and Pancreatic Surgery, Department of Abdominal Surgery and Transplantation, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain UCL, Hippocrate Avenue 10, 1200, Brussels, Belgium
    World J Surg 34:2648-61. 2010
    ..This study was designed to compare the results of surgical resection in patients with pancreatic cancer with or without vascular resection. Late 10-year disease-free survival was considered as an indicator of patients' disease cure...
  25. ncbi EUS analysis of collateral veins inside and outside the esophageal wall in portal hypertension
    A Irisawa
    Department of Internal Medicine II, Fukushima Medical University, School of Medicine, Fukushima City, Japan
    Gastrointest Endosc 50:374-80. 1999
    ..The relation between esophageal varices and venous collaterals outside the esophageal wall in patients with portal hypertension remains unclear. We investigated this relationship with endoscopy and endoscopic ultrasound (US)...
  26. ncbi Peripheral MR angiography: separation of arteries from veins with flow-spoiled gradient pulses in electrocardiography-triggered three-dimensional half-Fourier fast spin-echo imaging
    Mitsue Miyazaki
    MR Imaging Department, Toshiba Medical Research and Development Center, 1385 Shimoishigami, Otawara City, Tochigi 324 8550, Japan
    Radiology 227:890-6. 2003
    ..evaluated a nonenhanced magnetic resonance (MR) angiographic technique that allows separation of arteries from veins. In 15 healthy subjects, peripheral MR angiography was performed with readout flow-spoiled gradient pulses in ..
  27. doi Venous hypoxia: a poorly studied etiological factor of varicose veins
    C S Lim
    Imperial Vascular Unit, Department of Surgery and Cancer, Faculty of Medicine, Charing Cross Hospital, Imperial College London, London, UK
    J Vasc Res 48:185-94. 2011
    ..media of varicosities is oxygenated by vasa vasorum as compared to only the outer two-thirds of media of normal veins. There was no evidence that differences exist between oxygen content of blood from varicose and non-varicose veins,..
  28. ncbi Increased pelvic vein thrombi in cryptogenic stroke: results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) study
    Steven C Cramer
    University of Washington, Seattle, USA
    Stroke 35:46-50. 2004
    ..The Paradoxical Emboli From Large Veins in Ischemic Stroke (PELVIS) study hypothesized that patients with cryptogenic stroke have an increased prevalence ..
  29. ncbi A novel vein graft model: adaptation to differential flow environments
    Zhihua Jiang
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610 0286, USA
    Am J Physiol Heart Circ Physiol 286:H240-5. 2004
    ..This novel model offers a robust, clinically relevant, statistically powerful small animal model for evaluation of high- and low-shear-regulated VG remodeling...
  30. pmc Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos
    Alexandre Trindade
    Centro de Informatica do Instituto Superior de Agronomia CIISA, Lisbon Technical University, Lisbon, Portugal
    Blood 112:1720-9. 2008
    ..5 (E10.5), showing a variable degree of premature arteriovenous fusion. Veins displayed ectopic expression of arterial markers...
  31. pmc Susceptibility mapping as a means to visualize veins and quantify oxygen saturation
    E M Haacke
    Department of Radiology, Wayne State University, Detroit, Michigan 48201, USA
    J Magn Reson Imaging 32:663-76. 2010
    To create an orientation-independent, 3D reconstruction of the veins in the brain using susceptibility mapping.
  32. doi Control of presacral venous bleeding during rectal surgery
    Stylianos Germanos
    Patision General Hospital, Athens, Greece
    Am J Surg 200:e33-5. 2010
    ..We described our experience of using the combination of a hemostatic matrix and an absorbable hemostat as an alternative method of hemostasis...
  33. ncbi Anatomy of the presacral venous plexus: implications for rectal surgery
    P Baque
    Laboratoire d Anatomie Normale, Faculté de Médecine de Nice, 06000 Nice, France
    Surg Radiol Anat 26:355-8. 2004
    The presacral venous plexus results from anastomoses between the lateral and median sacral veins, and courses into the pelvic fascia covering the anterior aspect of the body of the sacrum...
  34. pmc Finger vein recognition based on a personalized best bit map
    Gongping Yang
    School of Computer Science and Technology, Shandong University, Jinan 250101, China
    Sensors (Basel) 12:1738-57. 2012
    ..Experimental results show that PBBM achieves not only better performance, but also high robustness and reliability. In addition, PBBM can be used as a general framework for binary pattern based recognition...
  35. pmc Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice
    M Leitges
    Max Planck Institute for Experimental Endocrinology, Hannover, Germany
    J Clin Invest 108:1505-12. 2001
    ..Our data indicate that PKCdelta maintains SMC homeostasis and that its function in the vessel wall per se is crucial in the development of vein graft arteriosclerosis...
  36. ncbi Near-infrared finger vein patterns for personal identification
    Miyuki Kono
    Medical Systems Research Department, Central Research Laboratory, Hitachi Limited, 1 280 Higashi koigakubo Kokubunji shi, Tokyo 185 8601, Japan
    Appl Opt 41:7429-36. 2002
    ..The enhanced finger vein pattern enabled 678 persons to be successfully identified...
  37. ncbi Does the number and size of veins ligated at left-sided microsurgical subinguinal varicocelectomy affect semen analysis outcomes?
    Alan W Shindel
    Division of Urology, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Urology 69:1176-80. 2007
    ..To determine whether the preoperative and intraoperative findings at unilateral microsurgical subinguinal varicocelectomy are predictive of semen analysis changes postoperatively...
  38. pmc Relationship between the number of veins ligated in a varicocelectomy with testicular volume, hormonal levels and semen parameters outcome
    Fabio Firmbach Pasqualotto
    Divisão de Centro de Ciências Biológicas e da Saúde, Universidade de Caxias do Sul, RS, Brasil
    J Assist Reprod Genet 22:245-9. 2005
    Correlate semen analysis, hormones, and testicular volume with the number of veins ligated.
  39. pmc New endovascular method for transvascular exit of arteries and veins: developed in simulator, in rat and in rabbit with full clinical integration
    Johan Lundberg
    Department of Clinical Neuroscience, Karolinska Institutet and Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 5:e10449. 2010
    ..To minimize surgical risk we propose a novel endovascular technique, to create parenchymal access through endovascular methods...
  40. pmc The anatomy of the cardiac veins in mice
    Bogdan Ciszek
    Department of Anatomy, The Medical University of Warsaw, Poland
    J Anat 211:53-63. 2007
    ..coronary system in mice has been the studied in detail by many research laboratories, knowledge of the cardiac veins remains poor...
  41. doi Preoperative mapping venography in patients who require hemodialysis access: imaging findings and contribution to management
    Kristen Hyland
    Department of Radiology, Division of Interventional Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Vasc Interv Radiol 19:1027-33. 2008
    ..To analyze the use of preoperative venographic mapping in patients who require permanent hemodialysis access...
  42. doi Molecular differentiation and specialization of vascular beds
    Susana F Rocha
    Department Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, University of Munster, 48149 Munster, Germany
    Angiogenesis 12:139-47. 2009
    ..Even within the blood vessel network, some molecules and pathways selectively mark the endothelium of arteries, veins and capillaries and are thought to contribute to the differentiation of these vessels...
  43. ncbi Arteries, veins, Notch, and VEGF
    B M Weinstein
    Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cold Spring Harb Symp Quant Biol 67:155-62. 2002
  44. ncbi Notch ligand Delta-like 1 is essential for postnatal arteriogenesis
    Anne Limbourg
    Department of Cardiology, Medizinische Hochschule Hannover, Hannover, Germany
    Circ Res 100:363-71. 2007
    ..Thus, Dll1-mediated Notch activation regulates ephrin-B2 expression and postnatal arteriogenesis...
  45. ncbi Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
    S S Gerety
    Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Mol Cell 4:403-14. 1999
    Ephrin-B2 is a transmembrane ligand that is specifically expressed on arteries but not veins and that is essential for cardiovascular development...
  46. ncbi Arteries and veins: making a difference with zebrafish
    Nathan D Lawson
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 309, 6 Center Drive, Bethesda, Maryland 20892, USA
    Nat Rev Genet 3:674-82. 2002
    Arteries and veins are structurally different and have long been functionally defined by the direction of blood flow that they carry...
  47. pmc Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation
    Shane P Herbert
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Science 326:294-8. 2009
    ..Thus, directional control of progenitor migration drives arterial-venous segregation and generation of separate parallel vessels from a single precursor vessel, a process essential for vascular development...
  48. ncbi Comparison of blood counts in venous, fingertip and arterial blood and their measurement variation
    Z W Yang
    Morphometric Research Laboratory, North Sichuan Medical College, China
    Clin Lab Haematol 23:155-9. 2001
    ..Elevation of total leucocyte count in the fingertip blood was mainly due to the increase of granulocytes. Measurement with venous blood was of better precision than with fingertip or arterial blood...
  49. doi Arterial-venous specification during development
    Matthew R Swift
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Circ Res 104:576-88. 2009
    The major arteries and veins of the vertebrate circulatory system are formed early in embryonic development, before the onset of circulation, following de novo aggregation of "angioblast" progenitors in a process called vasculogenesis...
  50. ncbi Coronary magnetic resonance vein imaging: imaging contrast, sequence, and timing
    Reza Nezafat
    Department of Medicine Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Magn Reson Med 58:1196-206. 2007
    ..Cardiovascular MR (CMR) has the potential to image the coronary veins. In this study we propose and test CMR techniques and protocols for imaging the coronary venous anatomy...
  51. ncbi Reactivity of human placental chorionic plate vessels is modified by level of oxygenation: differences between arteries and veins
    M Wareing
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 27:42-8. 2006
    ..Small arteries and veins from the chorionic plate were dissected from biopsies from term placentae of uncomplicated pregnancies and studied ..
  52. ncbi Definition of venous reflux in lower-extremity veins
    Nicos Labropoulos
    Department of Surgery, Loyola University Medical Center, 2160 First Avenue, Maywood, IL 60153 3304, USA
    J Vasc Surg 38:793-8. 2003
    This prospective study was designed to determine the upper limits of normal for duration and maximum velocity of retrograde flow (RF) in lower extremity veins.
  53. ncbi Physical examination may miss the diagnosis of bilateral varicocele: a comparative study of 4 diagnostic modalities
    Yigal Gat
    Andrology Unit, Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Urol 172:1414-7. 2004
    ..We evaluated the sensitivity of 3 noninvasive methods for detecting left and right varicoceles...
  54. ncbi Color Doppler sonographic evaluation of inter-relations between diameter, reflux and flow volume of testicular veins in varicocele
    Ercan Kocakoc
    Department of Radiology, Faculty of Medicine, Firat University, Elazig, Turkey
    Eur J Radiol 47:251-6. 2003
    ..We proposed to assess the relationship of vein diameters with the incidence, duration and flow volume of reflux using color Doppler sonography (CDS) in patients with clinically diagnosed varicocele...
  55. ncbi Gas embolism: pathophysiology and treatment
    Robert A van Hulst
    Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Physiol Funct Imaging 23:237-46. 2003
    ..A few animal studies are presented, which emphasize the importance of the timing of therapy, and the outcome of patients with air embolism (including clinical patients, divers and submariners) is described...
  56. ncbi Varicocele, hypoxia and male infertility. Fluid Mechanics analysis of the impaired testicular venous drainage system
    Yigal Gat
    Andrology Unit, Department of Obstetrics and Gynecology, Tel Aviv University, Israel
    Hum Reprod 20:2614-9. 2005
    ..This poses an enigma to clinicians: How can left-sided varicocele causes bilateral testicular dysfunction?..
  57. pmc Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
    R H Adams
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Genes Dev 13:295-306. 1999
    ..Interaction between ephrinB2 on arteries and its EphB receptors on veins suggests a role in defining boundaries between arterial and venous domains...
  58. pmc Visualization of coronary venous anatomy by cardiovascular magnetic resonance
    John F Younger
    Academic Unit of Cardiovascular Medicine, University of Leeds, Leeds, UK
    J Cardiovasc Magn Reson 11:26. 2009
    ..The aim of this study was to determine if the coronary venous anatomy could be depicted as part of a comprehensive CMR protocol and using a standard extracellular contrast agent...
  59. ncbi Wing vein patterning in Drosophila and the analysis of intercellular signaling
    Seth S Blair
    Department of Zoology, University of Wisconsin, Madison, WI 53706, USA
    Annu Rev Cell Dev Biol 23:293-319. 2007
    The positioning and elaboration of ectodermal veins in the wing of Drosophila melanogaster rely on widely utilized developmental signals, including those mediated by EGF, BMP, Hedgehog, Notch, and Wnt...
  60. ncbi A positive compression ultrasonography of the lower limb veins is highly predictive of pulmonary embolism on computed tomography in suspected patients
    Gregoire Le Gal
    EA 3878, département de médecine interne et de pneumologie, CHU de la Cavale Blanche, 29609 Brest Cedex, France
    Thromb Haemost 95:963-6. 2006
    The presence of a clot-- even asymptomatic-- in the proximal lower limb veins of a patient with clinically suspected pulmonary embolism (PE) provides evidence for venous thromboembolism and indicates anticoagulant therapy in such ..
  61. ncbi Vasoconstricting effect of angiotensin II in human hand veins: influence of aging, diabetes mellitus and hypertension
    Kazuhiro Harada
    Kasaoka Daiichi Hospital, Yokoshima, Kasaoka, Japan
    Hypertens Res 25:683-8. 2002
    We examined human hand veins to determine whether venoconstricting response to angiotensin II (Ang II) and noradrenaline (NA) was influenced by aging or such diseases as diabetes mellitus (DM) and hypertension (HT)...
  62. pmc Permanent occlusion of feeding arteries and draining veins in solid mouse tumors by vascular targeted photodynamic therapy (VTP) with Tookad
    Noa Madar-Balakirski
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 5:e10282. 2010
    ..vascular targeted photodynamic therapy (VTP) promotes permanent arrest of tumor blood supply by rapid occlusion of the tumor feeding arteries (FA) and draining veins (DV), leading to tumor necrosis and eradication within 24-48 h.
  63. ncbi Synthesis of collagen is dysregulated in cultured fibroblasts derived from skin of subjects with varicose veins as it is in venous smooth muscle cells
    Patricia Sansilvestri-Morel
    Division of Angiology, Servier Research Institute, Suresnes, France
    Circulation 106:479-83. 2002
    The dilatation and tortuosity observed in varicose veins provide evidence for progressive venous wall remodeling associated with abnormalities of smooth muscle cells and extracellular matrix...
  64. ncbi Sonographic quantitative evaluation of scrotal veins in healthy subjects: normative values and implications for the diagnosis of varicocele
    Alessandro Cina
    Department of Radiology, Agostino Gemelli Hospital, Catholic University, Rome, Italy
    Eur Urol 50:345-50. 2006
    ..To define the normative values of scrotal vein diameters, investigate the eventual presence and characteristics of scrotal reflux in healthy subjects, and describe its implication for the diagnosis of scrotal varicocele...
  65. ncbi Plasma ATP during exercise: possible role in regulation of coronary blood flow
    Martin Farias
    Dept of Physiology and Biophysics, 357290, University of Washington School of Medicine, Seattle, WA 98195 7290, USA
    Am J Physiol Heart Circ Physiol 288:H1586-90. 2005
    ..01). Coronary venous-arterial plasma ATP concentration difference increased significantly during exercise (P < 0.05). The data support the hypothesis that ATP is one of the factors controlling coronary blood flow during exercise...
  66. ncbi Valves in small veins and venules
    A Caggiati
    Department of Anatomy, University La Sapienza, Rome, Italy
    Eur J Vasc Endovasc Surg 32:447-52. 2006
    It is commonly believed that valves are absent in veins smaller than two millimetres in diameter...
  67. ncbi Differential response of arteries and veins to bipolar vessel sealing: evaluation of a novel reusable device
    Sven Richter
    Department of General, Visceral, Vascular, and Pediatric Surgery, University of Saarland, Homburg, Germany
    J Laparoendosc Adv Surg Tech A 16:149-55. 2006
    ..Using a porcine model we studied the efficacy of the novel reusable BiClamp versus the standard disposable LigaSure bipolar vessel sealing device. We also compared whether arteries respond differently than veins upon sealing.
  68. pmc Venous structures at the craniocervical junction: anatomical variations evaluated by multidetector row CT
    S Tanoue
    Department of Radiology, Oita University Faculty of Medicine, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita, 879 5593, Japan
    Br J Radiol 83:831-40. 2010
    The aim of this study was to evaluate the anatomy of and normal variations in the craniocervical junction veins. We retrospectively reviewed 50 patients who underwent contrast-enhanced CT with a multidetector scanner...
  69. doi Inhibitory effect of TIMP influences the morphology of varicose veins
    B Aravind
    Department of Surgery and Cancer, Faculty of Medicine, Imperial College, and Department of Histopathology, Charing Cross Hospital, London, UK
    Eur J Vasc Endovasc Surg 40:754-65. 2010
    ..matrix metalloproteinase enzymes (MMP) and their inhibitors (TIMPs) may contribute to the development of varicose veins. We hypothesised that, histological changes in varicose vein wall correlate with alterations in expression of MMP/..
  70. ncbi Exercise during a 3-min decompression stop reduces postdive venous gas bubbles
    Zeljko Dujic
    Department of Physiology and Biophysics, University of Split School of Medicine, Split, Croatia
    Med Sci Sports Exerc 37:1319-23. 2005
    ..The objective of this field study was to evaluate whether mild, continuous exercise during decompression has a similar impact...
  71. pmc Aerobic exercise before diving reduces venous gas bubble formation in humans
    Zeljko Dujic
    Department of Physiology and Biophysics, University of Split School of Medicine, Split, Croatia
    J Physiol 555:637-42. 2004
    ..5 (P= 0.002) by pre-dive exercise, thereby increasing safety. This is the first report to indicate that pre-dive exercise may form the basis for a new way of preventing serious decompression sickness...
  72. ncbi Vascular development: from precursor cells to branched arterial and venous networks
    Anne Eichmann
    INSERM U36, College de France, Paris, France
    Int J Dev Biol 49:259-67. 2005
    ..the embryo, of their assembly into the primary vascular plexus and of the remodeling of this plexus into arteries and veins. We also focus on the molecular mechanisms controlling the development of arteries, veins and lymphatic vessels.
  73. ncbi Vortex veins: anatomic investigations on human eyes
    Tunc Kutoglu
    Department of Anatomy, Trakya University, Edirne, Turkey
    Clin Anat 18:269-73. 2005
    The aim of this study was to determine number of ocular vortex veins, their scleral coordinates, and their relationship with nearby extraocular muscles...
  74. ncbi Collateral pathways in thoracic central venous obstruction: three-dimensional display using direct spiral computed tomography venography
    Hyo Cheol Kim
    Department of Radiology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    J Comput Assist Tomogr 28:24-33. 2004
    ..Venous structures that can be demonstrated with CT venography include the jugular veins; the subclavian and brachiocephalic (innominate) veins; the internal and lateral thoracic veins; the superior and ..
  75. pmc Specification of arterial, venous, and lymphatic endothelial cells during embryonic development
    Tsutomu Kume
    Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Histol Histopathol 25:637-46. 2010
    ....
  76. doi The use of autogenous veins for microsurgical repair of the sural nerve after nerve biopsy
    Leandro Pretto Flores
    Unit of Neurosurgery, Hospital de Base do Distrito Federal Brasília, Distrito Federal, Brazil
    Neurosurgery 66:238-43; discussion 243-4. 2010
    ..This study evaluates the results of an alternative technique developed to minimize the risk of complications associated with sural nerve biopsy for histopathological analysis...
  77. doi Cardiac veins: a review of the literature
    Marios Loukas
    Department of Anatomical Sciences, School of Medicine, St George s University, Grenada, West Indies
    Clin Anat 22:129-45. 2009
    Cardiac veins have long stood in the shadow of their more extensively studied counterparts, the coronary arteries. The clinical importance of the coronary venous system, nonetheless, should not be underestimated...
  78. ncbi Refinement of venous reconstruction using cryopreserved veins in right liver grafts
    Yasuhiko Sugawara
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    Liver Transpl 10:541-7. 2004
    ..When reconstruction of multiple short hepatic veins was necessary, a cryopreserved inferior vena cava graft was anastomosed with the hepatic veins of the graft in a ..
  79. ncbi Incidence and importance of reflux in testicular veins of healthy men evaluated with color duplex sonography
    Ercan Kocakoc
    Department of Radiology, Faculty of Medicine, Firat University, 23119 Elazig, Turkey
    J Clin Ultrasound 30:282-7. 2002
    Reflux in the testicular veins plays a crucial role in the diagnosis of a varicocele...
  80. doi Annexin A5 therapy attenuates vascular inflammation and remodeling and improves endothelial function in mice
    Mark M Ewing
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 31:95-101. 2011
    ..Annexin A5 (AnxA5) has antithrombotic, antiapoptotic, and antiinflammatory properties; we investigated its effectiveness against vascular inflammation, remodeling, and dysfunction in accelerated atherosclerosis...
  81. ncbi Objective assessment of blood stasis using computerized inspection of sublingual veins
    Chuang Chien Chiu
    Institute of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ROC
    Comput Methods Programs Biomed 69:1-12. 2002
    In traditional Chinese tongue diagnosis, inspection of the sublingual veins has been developed as a new diagnostic examination method especially for determining blood stasis...
  82. ncbi Reproducibility of ultrasound scan in the assessment of volume flow in the veins of the lower extremities
    Tomohiro Ogawa
    Department of Surgery, University of Hawaii, John A Burns School of Medicine, and the Straub Foundation and Straub Clinic and Hospital, Honolulu, HI 96814, USA
    J Vasc Surg 35:527-31. 2002
    The purpose of this study was the identification of the optimal settings of ultrasound scan flow measurement in the veins and the determination of whether the standardization of these settings can provide acceptable reproducibility of ..
  83. doi Mapping of superficial extremity veins: normal diameters and trends in a vascular patient-population
    Dan E Spivack
    Department of Surgery, Section of Vascular Surgery, Temple University, Philadelphia, PA 19140, USA
    Ultrasound Med Biol 38:190-4. 2012
    Ultrasonic measurement of superficial extremity veins is a common procedure...
  84. ncbi Tacrolimus inhibits intimal hyperplasia in arterialised veins in rats
    M Varga
    Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Bratisl Lek Listy 113:5-9. 2012
    ..We investigated whether tacrolimus (FK506) can inhibit neointimal formation in arterialised vein grafts in rats...
  85. doi Superficial venous thrombosis: prevalence of common genetic risk factors and their role on spreading to deep veins
    Glauco Milio
    University of Palermo Department of Internal Medicine, Cardiovascular and Nephrourological Diseases, Italy
    Thromb Res 123:194-9. 2008
    ..long time a limited clinical condition with a low importance, but this approach has changed in recent years, when several studies demonstrated spreading to deep veins occurring from 7.3 to 44%, with high prevalence of pulmonary embolism.
  86. pmc Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins
    Hsin Kai Liao
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa 50011, USA
    Dev Dyn 241:415-25. 2012
    ..The transposon integrations are predicted to disrupt the appa and aplp2 genes to primarily produce secreted ectodomains of the corresponding proteins that are fused to RFP...
  87. ncbi Heterogeneity in hand veins responses to acetylcholine is not associated with polymorphisms in the G-protein beta3-subunit (C825T) and endothelial nitric oxide synthase (G894T) genes but with serum low density lipoprotein cholesterol
    M Grossmann
    Institute of Clinical Pharmacology, Medical Faculty of the University of Technology Dresden, Germany
    Pharmacogenetics 11:307-16. 2001
    ..The dorsal hand vein technique was used in 37 healthy subjects. Hand veins were preconstricted with the alpha1-adrenoceptor agonist phenylephrine and the venodilator response to local ACh ..
  88. ncbi Amino acid flux in ruminal and gastric veins of sheep: effects of ruminal and omasal injections of free amino acids and carnosine
    D Remond
    Unite de Recherches sur les Herbivores, Institut National de la Recherche Agronomique de Clermont Ferrand, Genès Champanelle, France
    J Anim Sci 78:158-66. 2000
    ..Before injections, a net uptake of each of these FAA was measured in the ruminal and the gastric veins. The ruminal injections produced a linear increase in ruminal FAA concentration...
  89. doi Visualizing veins with near-infrared light to facilitate blood withdrawal in children
    Natascha J Cuper
    University Medical Center, Utrecht, Netherlands
    Clin Pediatr (Phila) 50:508-12. 2011
    This study aims to evaluate for the first time the value of visualizing veins by a prototype of a near-infrared (NIR) vascular imaging system for venipuncture in children.
  90. ncbi Autonomic control of the venous system in health and disease: effects of drugs
    C C Pang
    Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, B C V6T 1Z3, Canada
    Pharmacol Ther 90:179-230. 2001
    ..In humans, drugs that interfere with sympathetic tone can cause the pooling of blood in limb as well as splanchnic veins; the reduction of cardiac output; and orthostatic intolerance...
  91. doi Characterization of local vascular effects of the nitric oxide inhibitor NG-monomethyl-L-arginine on dorsal hand veins
    Christoph Schindler
    Institute of Clinical Pharmacology, Medical Faculty, Technical University Dresden, Fiedlerstrasse 27, D 01307 Dresden, Germany
    J Clin Pharmacol 52:859-69. 2012
    Infusion of NG-monomethyl-L-arginine (L-NMMA; 6.4 µmol/min) into hand veins can cause a 20% increase in vein size in specific subjects. This study explored potential underlying mechanisms in healthy male participants...
  92. ncbi SERCA pump isoform expression in endothelium of veins and arteries: every endothelium is not the same
    I Khan
    Department of Biochemistry, Faculty of Medicine, Kuwait University
    Mol Cell Biochem 203:11-5. 2000
    ..Smooth muscle from all arteries and veins expressed only the SERCA2 mRNA...
  93. ncbi MAPping out arteries and veins
    Ryan E Lamont
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary AB, Canada T2N 4N1, Canada
    Sci STKE 2006:pe39. 2006
    Growing evidence suggests that a genetic program specifies the identity of arteries and veins before the onset of circulation...
  94. ncbi Relationship between arm pain and distension of arteries and veins caused by elevation of transmural pressure in local vascular segments
    O Eiken
    Aviation Medicine Dept, National Defence Research Establishment, Karolinska Institutet, Stockholm, Sweden
    Aviat Space Environ Med 72:427-31. 2001
    ..The purpose of the present investigation was to study the pressure-distension relation of veins and arteries in the human arm and the relation between arm pain and distension of local vessels.
  95. doi Primary balloon angioplasty of small (≤2 mm) cephalic veins improves primary patency of arteriovenous fistulae and decreases reintervention rates
    Pierfrancesco Veroux
    Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, Catania, Italy
    J Vasc Surg 57:131-6. 2013
    The purpose of this study was to evaluate the effect of primary balloon angioplasty (PBA) of cephalic veins with diameter≤2 mm on patency and maturation time of autogenous radiocephalic arteriovenous fistulae (AVF) for hemodialysis.
  96. ncbi Venous bubble count declines during strenuous exercise after an open sea dive to 30 m
    Zeljko Dujic
    Department of Physiology, University of Split School of Medicine, Croatia
    Aviat Space Environ Med 77:592-6. 2006
    ..The objective of this study was to determine whether a short period of strenuous post-dive exercise promotes venous bubble formation...
  97. doi Arteriovenous fistula formation using transposed basilic vein: extensive single centre experience
    S J F Harper
    Department of Infection, Immunity and Inflammation, Transplantation Division, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 36:237-41. 2008
    ..The expanding haemodialysis population has lead to increased requirement for more complex vascular access. The aim of this study is to present the results of an extensive series of brachiobasilic arteriovenous fistulae...
  98. pmc An immunological fingerprint differentiates muscular lymphatics from arteries and veins
    Eric A Bridenbaugh
    Department of Medical Physiology, Division of Lymphatic Biology, Texas A and M Health Science Center College of Medicine, Temple, Texas
    Lymphat Res Biol 11:155-71. 2013
    ..prenodal mesenteric microlymphatics and large, postnodal thoracic duct) to axillary and mesenteric arteries and veins isolated from rats...
  99. ncbi A case of idiopathic spinal epidural lipomatosis presented with radicular pain caused by compression with enlarged veins surrounding nerve roots
    M Kawai
    Department of Neurology, Sumitomo Hospital, Osaka, Japan
    Acta Neurol Scand 105:322-5. 2002
    To report a case of idiopathic spinal epidural lipomatosis (SEDL) presented with unique radicular pain most likely caused by enlarged veins surrounding nerve roots.
  100. doi Reinterpreting the magnetic resonance signs of hemodynamic impairment in the brains of multiple sclerosis patients from the perspective of a recent discovery of outflow block in the extracranial veins
    Marian Simka
    Private Healthcare Institution SANA, Department of Angiology, Pszczyna, Poland
    J Neurosci Res 88:1841-5. 2010
    ..imaging utilizing deoxyhemoglobin as the contrast has revealed that venous blood in cerebral veins of multiple sclerosis patients is less deoxygenated compared with healthy controls...
  101. pmc Laparoscopic versus open high ligation of the testicular veins for the treatment of varicocele
    G A Bebars
    General Surgery Department, Mafraq Hospital, Abu Dhabi, United Arab Emirates
    JSLS 4:209-13. 2000
    ..While 65 patients were treated by open high ligation of the testicular veins, 128 patients had laparoscopic varicocelectomy...

Research Grants72

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Vein Occlusions Number: 11-EI-0263 Background: - Branch retinal vein occlusion (BRVO) is a blockage of the small veins that carry blood away from the retina in the back of the eye...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Vein Occlusions Number: 11-EI-0263 Background: - Branch retinal vein occlusion (BRVO) is a blockage of the small veins that carry blood away from the retina in the back of the eye...
  3. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..to serum growth factors as well as their inhibition by NO, and compare the responses between cells derived from veins that ultimately do or do not mature successfully...
  4. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..We have documented the presence of PSA-NCAM in the glycocalyx of human vascular endothelial cells in arteries, veins and lymphatics of all organs (10 organ systems) studied...
  5. SMOOTH MUSCLE MYOSIN PHOSPHATASE SUBUNIT ISOFORMS
    Steven A Fisher; Fiscal Year: 2013
    ..vein and mesenteric resistance arteries, and skipped in the slow (tonic) smooth muscle of the large arteries and veins. A switch from E23 skipping to splicing occurs in the perinatal period in tissues that acquire a fast phenotype...
  6. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    ..In this regard, recent studies indicate an important role for the pulmonary veins and the posterior left atrium (PLA) in the genesis of this arrhythmia...
  7. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..the hepatic portal vein and the hepatic vein, as well as in other vessels and sites as needed (splenic and jejunal veins, carotid and vertebral arteries, the 3rd ventricle etc.)...
  8. Molecular Basis of Nuchal Edema
    Young Kwon Hong; Fiscal Year: 2013
    ..for the nuclear receptor COUP-TFII, a finding that indicates the key role of COUP-TFII in Notch repression in the veins. We also discovered that two Down syndrome-associated genes DSCR1 and Dyrk1a, when ectopically expressed in ..
  9. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2013
    ..In this regard, recent studies indicate an important role for the pulmonary veins and the posterior left atrium (PLA) in the genesis of this arrhythmia...
  10. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    ..that has a critical role in determining left-right asymmetry, and the development of the left atrium and pulmonary veins. Ectopic electrical foci within the pulmonary veins initiates fibrillatory activity and is the target of catheter ..
  11. Identifying a role for commensal bacteria on the liver immune priming environment
    Jean Publicover; Fiscal Year: 2013
    ..Additionally, blood from the mesenteric veins flows directly to the liver via the portal vein, allowing for the liver to be directly expose to bacterial ..
  12. Neurohumoral control of veins in hypertension
    Gregory D Fink; Fiscal Year: 2013
    ..The three central and complementary themes of this Program Project are: veins play an important role in the long-term control of arterial pressure;neurohumoral mechanisms regulating venous ..
  13. Role of Fibrinolytic System in Vein Graft Remodeling
    William P Fay; Fiscal Year: 2013
    ..In addition, the process of venous arterialization has major clinical significance, as saphenous veins are used to perform arterial bypass grafting in patients with advanced coronary artery and peripheral artery ..
  14. Pathogenetics of the FOX transcription factor gene cluster on 16q24.1
    Pawel Stankiewicz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a lethal neonatal diffuse developmental disorder of the lungs, which is commonly associated with multiple congenital ..
  15. PTEN Gene Therapy for Vein Graft Disease
    Christopher D Kontos; Fiscal Year: 2010
    ..S. and other developed countries. Autologous saphenous veins are the most commonly used conduits for bypass grafting in both coronary and peripheral artery disease, and ..
  16. Transcriptional Control of Liver Development
    Joshua Friedman; Fiscal Year: 2009
    ..Most of these cells mature into hepatocytes, but some of those surrounding the portal veins develop into the ductal plate, which gives rise to the bile ducts...
  17. Rescue of developmental disorders in utero by gene-specific small molecules
    Michael J Higgins; Fiscal Year: 2011
    ..uptake into embryos, and their efficacy in utero, we will first inject fluorescently labeled PIPs into the tail veins of pregnant mice carrying wild type embryos at various time points during gestation;embryos will then be examined ..
  18. Fibrotic effects and regulation of MMP proteins in thrombus resolution
    Rajabrata Sarkar; Fiscal Year: 2009
    ..RELEVANCE: This proposalwill determine how matrix metalloproteinase proteins cause scarring and thickening of veins after blood clots, which can cause later leg pain, swelling and ulcers...
  19. Mechanisms of the Age-related Alterations in Lymphatic Pumping
    Anatoliy A Gashev; Fiscal Year: 2012
    ..to transport fluid, soluble molecules and cells from the interstitium through the lymph nodes to the central veins. The lymphatic system plays important roles in body fluid circulation, macromolecular homeostasis, fat absorption, ..
  20. Minimally Invasive Surgical Pulmonary Vein Insolation vs. Medical Management in P
    MICHAEL FARRIS WATERS; Fiscal Year: 2010
    ..Literature in recent years has shown atrial fibrillation is often initiated by ectopic foci in the pulmonary veins and accordingly, there has been an explosion of catheter- based and minimally invasive surgical approaches to ..
  21. Computer-Aided Detection of Pulmonary Embolism on CT Pulmonary Angiography
    Chuan Zhou; Fiscal Year: 2012
    ..4) developing robust pulmonary vessel tree reconstruction method to accurately track pulmonary vessels, trim veins and surrounding extensive lung diseases from vessel tree, and label reconstructed arterial tree, (5) developing ..
  22. Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous Insufficiency
    Raouf A Khalil; Fiscal Year: 2013
    ..venous insufficiency (CVI) is a common and costly disease characterized by excessive vein dilation and varicose veins. CVI commonly occurs in the lower extremity, suggesting a role of venous pressure and vein wall stretch...
  23. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul E Bock; Fiscal Year: 2010
    ..Relevance. Blood clots occurring abnormally in the deep veins of the legs can break apart in the circulation and lodge in the lungs, resulting in life-threatening thrombosis...
  24. Induction of uterine vascular remodeling by myometrial stretch
    George J Osol; Fiscal Year: 2013
    ..of the rat uterus in the nonpregnant state leads to significant expansive growth of the mesometrial arteries and veins similar to that seen in pregnancy...
  25. Venous Malformations (VM): A Murine Model to Identify Therapies to Target Aberran
    Elisa Boscolo; Fiscal Year: 2013
    ..VMs are lesions composed by widened, abnormally shaped veins. Smooth muscle cells are absent in many areas...
  26. VERGFR-1 in the Uterine Circulation During Pregnancy
    George J Osol; Fiscal Year: 2011
    ..Aim 2 will characterize the localization and molecular biology of this receptor in uterine arteries and veins as a function of gestation and vessel size, and determine how shear stress and estrogen affect its expression...
  27. Albumin AFP Gene Family Regulation in Fetal and Adult Liver
    Brett T Spear; Fiscal Year: 2013
    ..A number of agents (alcohol, drugs and toxins) preferentially damage hepatocytes surrounding the central veins due to restricted expression of P450 enzymes in these cells...
  28. Commercialization of Tissue Lined Stent Graft for Dialysis Access Failure
    DON GUSTAVSON; Fiscal Year: 2013
    ..all patients can wait the length of time for the fistula to mature or it cannot be used for people with fragile veins. Thus, s the number of Americans with end-stage renal disease (ESRD) continues to rise, the use of grafts will ..
  29. Real-time multiphoton microscopy of periprostatic tissue architecture
    Ashutosh K Tewari; Fiscal Year: 2010
    ..identify all relevant tissue types (prostatic capsule, cavernous nerve, prostatic acinar cells, fat, arteries, and veins)by MPM/SHG imaging in a rat model...
  30. Comparative effectiveness of catheter ablation vs medical therapy for atrial fibr
    James Freeman; Fiscal Year: 2013
    ..for atrial fibrillation (AF), using radiofrequency energy or cryotherapy to electrically isolate the pulmonary veins and eliminate arrhythmia foci, is a new therapy that is currently used to treat 50,000 patients per year in the ..
  31. Computed Tomography to Predict Response to Cardiac Resynchronization Therapy
    Quynh A Truong; Fiscal Year: 2013
    ..CT study of 60 patients to evaluate the role of dual-source CT (with dyssynchrony, myocardial scar, and coronary veins) in the CRT population and a translational biomarker study of 300 patients (cohort 1-240 CRT patients, cohort 2-60 ..
  32. Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension
    Flemming Forsberg; Fiscal Year: 2013
    ..The SHAPE gradient between the portal and hepatic veins was in good agreement with the corresponding HVPG (R = 0.82)...
  33. Biocompatible Chemical Sensors Via Nitric Oxide Release/Generation
    Mark E Meyerhoff; Fiscal Year: 2013
    ..will be evaluated side-by-side via in vivo studies with coated sensors implanted intravascularly (arteries and veins) within pigs and rabbits...
  34. Mechanisms of Venous Thromboembolism in Cancer
    Nigel Mackman; Fiscal Year: 2012
    ..Public Health Relevance: Development of blood clots in veins or venous thrombosis is a leading cause of death and disability among cancer patients...
  35. Elastogenic Factor Functionalized Electrospun Scaffolds for in vivo Generation of
    CHRISTOPHER A BASHUR; Fiscal Year: 2013
    ..The use of autologous saphenous veins as bypass grafts for occluded vessels are constrained by unavailability in patients with systemic vascular disease,..
  36. Elucidating the mechanisms of venous reprogramming during coronary development
    MARY K RED-HORSE; Fiscal Year: 2011
    ..Subsequently, the vessels differentiate into arteries, capillaries, or veins depending on their location within the heart...
  37. Multiscale, Transport-Dependent NO Signaling: Cells to Vascular Networks
    Dov Jaron; Fiscal Year: 2013
    ..with vessel diameter measurements, will be obtained from individual small arteries, arterioles, venules, and small veins under normal and abnormal physiological conditions to characterize relationships among vascular diameter, NO, ..
  38. Deep Vein Thrombosis and Chronic Thrombotic Venous Disease
    Timothy A Morris; Fiscal Year: 2012
    ..CTVD is characterized by remodeling of thrombotic material within the deep veins into intravascular scars that obstruct blood flow...
  39. Noninvasive and Accurate Measurement of Portal Hypertension
    Flemming Forsberg; Fiscal Year: 2010
    Portal hypertension is defined as an increase in the pressure gradient between the portal vein and hepatic veins or the inferior vena cava (IVC)...
  40. The Role of Sema3D in Cardiac Development
    Karl Degenhardt; Fiscal Year: 2013
    ..Moreover, the pulmonary veins are prone to stenosis, which frequently complicates the treatment of patients with TAPVR and other forms of CHD...
  41. Mechanisms of cGMP-Mediated Vasodilation in Perinatal Lung
    J Usha Raj; Fiscal Year: 2010
    ..This novel and new hypothesis will be explored in this proposal. In isolated intrapulmonary arteries and veins and in vascular smooth muscle cells cultured from these vessels, we will first test the hypothesis that hypoxia-..
  42. The Contribution of Melanocyte-like Cells to Atrial Function and Development
    Vickas V Patel; Fiscal Year: 2013
    ..provided by applicant): We recently described a novel population of melanocyte-like cells in the pulmonary veins and atria of humans and mice...
  43. In vivo real-time detection of circulating melanoma cells
    Vladimir P Zharov; Fiscal Year: 2013
    ..for real-time, label-free detection of melanoma cells will be verified by the injection of cells into the tail veins of mice. Aim 3...
  44. Stanford Career Development in Vascular Medicine
    John P Cooke; Fiscal Year: 2012
    ..Lay description: Diseases of the arteries and veins cause most of the hospitalizations and deaths in the United States...
  45. Methods To Reduce Vein Harvest Injury
    Joyce Cheung-Flynn; Fiscal Year: 2013
    ..by which P2X7R antagonism restores viability and functional responses after stretch injury in porcine saphenous veins and 2) Determine if stretch injury accelerates intimal hyperplasia and whether P2X7R blockade will reduce intimal ..
  46. Assessment of Reconstructive Surgical Flaps Using Spatially Resolved Tissue Oxima
    Anthony J Durkin; Fiscal Year: 2012
    ..flaps is a method of moving tissue from a donor location to recipient location and re-attaching the arteries &veins to the blood vessels at the recipient site...
  47. A Nanofibrous Bioactive Hemodialysis Access Graft
    SAIF G PATHAN; Fiscal Year: 2010
    ..applicant): Current gold standards for hemodialysis access, radial cephalic vein fistulas and autogenous saphenous veins, have significant problems associated with their use...
  48. Evaluation of Vascular Malformation Hemodynamics Using ASL Perfusion MRI
    Ronald L Wolf; Fiscal Year: 2010
    ..malformation (AVM) is a vascular malformation in the brain with direct connections between arteries and veins such that blood bypasses brain tissue...
  49. Elucidating the mechanisms of venous reprogramming during coronary development
    MARY K RED-HORSE; Fiscal Year: 2013
    ..Subsequently, the vessels differentiate into arteries, capillaries, or veins depending on their location within the heart...
  50. Lung Endothelial Cell Phenotypes
    Troy Stevens; Fiscal Year: 2013
    ..project grant is founded on the overall hypothesis that endothelium lining pulmonary arteries, capillaries, and veins is phenotypically distinct;each cell type is highly specialized to fulfill he unique demands of its vascular niche...
  51. C-Arm CT for Guidence of Cardiac Interventions
    Rebecca Fahrig; Fiscal Year: 2010
    ..One of our goals is to demonstrate the ability to depict the left atrium and pulmonary veins to provide guidance accuracy of better then 2 mm, and to reduce the time required for registration by 50% (~20 ..
  52. A Nanofibrous Bioactive Hemodialysis Access Graft
    SAIF G PATHAN; Fiscal Year: 2013
    ..access to treat End-Stage Renal Disease (ESRD), radial cephalic vein fistulas and autogenous saphenous veins, have significant problems associated with their use...
  53. Fox Transcription Factors in Vascular Development
    Tsutomu Kume; Fiscal Year: 2012
    ..Prox1/VEGF-R3+ LECs subsequently bud from the veins via paracrine VEGF-C signaling, leading to the formation of the lymphatic vasculature...
  54. Functional and Structural Optical Coherence Tomography for Glaucoma
    David Huang; Fiscal Year: 2013
    ..Improve Doppler OCT measurement of retinal blood flow. Multi-circular scans of peripapillary retinal arteries and veins measure total retinal blood flow in 2 seconds...
  55. Percutaneous cardiac HIFU ablation with multimodal image guidance
    Douglas N Stephens; Fiscal Year: 2013
    ..To treat the AF the most common anatomical target for ablation is the entrance of pulmonary veins and the surrounding tissue...
  56. Molecular regulation of vein graft adapation
    Alan Dardik; Fiscal Year: 2013
    ..with Ephrin- B2 ligand an embryonic determinant of arteries and Eph-B4 receptor an embryonic determinant of veins. We have recently shown in both humans and rats that diminished Eph-B4 expression and loss of venous identity is ..
  57. Non-contrast 4-D Dynamic MRA in Arteriovenous Malformation (AVM)
    DANNY JIONG JIONG WANG; Fiscal Year: 2013
    ..malformation (AVM) is a congenital vascular abnormality in the brain with direct connections between arteries and veins such that blood bypasses brain tissue...
  58. Regulation of Venous and Lymphatic Identity by Chromatin-Remodeling
    Courtney T Griffin; Fiscal Year: 2013
    ..Secondly, the epigenetic impact of BRG1 and CHD4 on Coup-TFII expression in veins and lymphatics will be examined...
  59. Notch Signaling in Arterial-Venous Specification
    Rong Wang; Fiscal Year: 2013
    ..The mechanism of AV coordination particularly that between paired, parallel arteries and veins is poorly understood. Our long-term objective is to elucidate the genetic program of mammalian AV circuitry...
  60. A Previously Unrecognized Site of Resistance in POAG
    Haiyan Gong; Fiscal Year: 2010
    ..that flow of fluorescein or trypan blue injected into SC of POAG eyes is blocked from entering the episcleral veins in certain regions...
  61. Regulation of Factor FVIII Secretion
    Randal J Kaufman; Fiscal Year: 2013
    ..is still problematic due to the high cost to manufacture rFVIII, shortage of supply, limited access to peripheral veins, and development of inhibitory antibodies...
  62. Real-time MRI-guided RF Ablation of Cardiac TachyArrhythmias
    Orhan Unal; Fiscal Year: 2010
    ..AF also accounts for 15% of all strokes. Ectopic electrical impulses originating in the pulmonary veins initiate AF in many patients...
  63. MICROVASCULAR PERMEABILITY OF THE CEREBRAL CIRCULATION
    WILLIAM MAYHAN; Fiscal Year: 1992
    ..Experiments that I have completed suggest that veins are the primary site of disruption of the BBB during acute hypertension, and disruption of the BBB in veins was ..
  64. VON WILLEBRAND FACTOR, FIBRINOLYSIS, & THE ENDOTHELIUM
    Karen Hamilton; Fiscal Year: 1991
    ..Experiments will be performed on cultured human endothelial cells obtained from umbilical veins, adult arteries and veins, and adipose tissue microvasculature. Intracellular vWF Structure and Release...
  65. FORMATION AND METABOLISM OF NITROSAMINES IN PIGS
    Peter Magee; Fiscal Year: 1991
    ..Advantages of this species include its greater size, allowing cannulation of the portal and hepatic veins, and the bile duct, from which relatively large samples can be obtained in the conscious animal...
  66. Thrombin Formation Inhibitors
    James Phillips; Fiscal Year: 2004
    Deep venous thrombosis (DVT) is a blood clot that has formed in one of the large veins far below the skin and blocks normal blood flow back to the heart...
  67. BRADYKININ RECEPTOR STUDIES--IMMUNOLOGICAL APPROACHES
    CHARLES ODYA; Fiscal Year: 1992
    ..myometrium and those from rat uterus, guinea pig ileum, dog carotid artery and rabbit jugular and mesenteric veins and aorta...
  68. The role of the vascular endothelium in schistosomiasis
    Melissa Beall; Fiscal Year: 2002
    ..Adult parasites survive for years within the mesenteric veins of their host, with intimate contact occurring between the dorsal surface of the male parasite and the vascular ..
  69. Antithrombotic Gene Therapy
    Pierre Zoldhelyi; Fiscal Year: 2006
    ..In addition, we hypothesize that treatment of injured arteries and grafted veins with both the TFPI and cyclooxygenase-1 (PGHS-1) genes will further improve the protection of the vascular ..
  70. SELECTIVE INNERVATION OF SA & AV NODAL REGIONS OF HEART
    Robert Wurster; Fiscal Year: 1992
    Aggregates of postganglionic cell bodies are localized in the fat pads overlying the entrance of right pulmonary veins (PVFP) into the atrium and at the junction of inferior vena cava and inferior left atrium (IVC-ILA), excision of which ..
  71. Role of metalloproteinases in deep vein thrombosis
    Khanh Nguyen; Fiscal Year: 2009
    ..by applicant): Deep vein thrombosis (DVT) is a disease condition where blood clots (thrombi) develop in deep veins, often veins of the lower extremities...
  72. ENDOTHELIN AND NEURAL CONTROL OF VEINS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 2002
    ..the deoxycorticosterone acetate (DOCA)-salt rat model of hypertension is caused partly by increased sensitivity of veins to endothelin-1 (ET-1) and to sympathetic neural input...