retinal vessels

Summary

Summary: The blood vessels which supply and drain the RETINA.

Top Publications

  1. ncbi Diabetic retinopathy
    Robert N Frank
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    N Engl J Med 350:48-58. 2004
  2. ncbi Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
    D W Dawson
    Department of Microbiology Immunology, Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 285:245-8. 1999
  3. ncbi Identification and functional analysis of endothelial tip cell-enriched genes
    Raquel del Toro
    Inserm U833, Paris, France
    Blood 116:4025-33. 2010
  4. ncbi Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia
    Jason A Vincent
    Case Western Reserve University, Department of Medicine, Division of Clinical and Molecular Endocrinology, Center for Diabetes Research, Cleveland, OH 44106, USA
    Diabetes 56:224-30. 2007
  5. ncbi Immunological mechanisms in the pathogenesis of diabetic retinopathy
    Anthony P Adamis
    Jerini Ophthalmic, Time and Life Building, 111 West 50th Street, 7th Floor, Gilman 7 422A, New York, NY 10020, USA
    Semin Immunopathol 30:65-84. 2008
  6. ncbi Development of the retinal vasculature
    Marcus Fruttiger
    UCL Institute of Ophthalmology, 11 43 Bath Street, London, EC1V 9EL, UK
    Angiogenesis 10:77-88. 2007
  7. ncbi Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
    Johane Robitaille
    Department of Ophthalmology, Izaak Walton Killam IWK Health Centre, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, Canada
    Nat Genet 32:326-30. 2002
  8. ncbi Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Diabetes 56:2380-7. 2007
  9. pmc Erythropoietin deficiency decreases vascular stability in mice
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:526-33. 2008
  10. ncbi Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response
    A Hoover
    Electrical and Computer Engineering Department, Clemson University, SC 29634 0915, USA
    IEEE Trans Med Imaging 19:203-10. 2000

Detail Information

Publications304 found, 100 shown here

  1. ncbi Diabetic retinopathy
    Robert N Frank
    Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    N Engl J Med 350:48-58. 2004
  2. ncbi Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
    D W Dawson
    Department of Microbiology Immunology, Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 285:245-8. 1999
    ..These results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness...
  3. ncbi Identification and functional analysis of endothelial tip cell-enriched genes
    Raquel del Toro
    Inserm U833, Paris, France
    Blood 116:4025-33. 2010
    ..Thus, tip cells may regulate angiogenesis via matrix remodeling, production of basement membrane, and release of secreted molecules, some of which regulate stalk cell behavior...
  4. ncbi Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia
    Jason A Vincent
    Case Western Reserve University, Department of Medicine, Division of Clinical and Molecular Endocrinology, Center for Diabetes Research, Cleveland, OH 44106, USA
    Diabetes 56:224-30. 2007
    ....
  5. ncbi Immunological mechanisms in the pathogenesis of diabetic retinopathy
    Anthony P Adamis
    Jerini Ophthalmic, Time and Life Building, 111 West 50th Street, 7th Floor, Gilman 7 422A, New York, NY 10020, USA
    Semin Immunopathol 30:65-84. 2008
    ..In addition, emerging therapeutic approaches based on ongoing investigations will be discussed, including those involving blockade of angiotensin receptors and other molecular targets such as tumor necrosis factor-alpha...
  6. ncbi Development of the retinal vasculature
    Marcus Fruttiger
    UCL Institute of Ophthalmology, 11 43 Bath Street, London, EC1V 9EL, UK
    Angiogenesis 10:77-88. 2007
    ..Such insight will provide the basis of future therapeutic approaches aimed at manipulating retinal blood vessels...
  7. ncbi Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
    Johane Robitaille
    Department of Ophthalmology, Izaak Walton Killam IWK Health Centre, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, Canada
    Nat Genet 32:326-30. 2002
    ..In one of the mutants, altered subcellular trafficking led to defective signaling. These findings support a function for frizzled-4 in retinal angiogenesis and establish the first association between a Wnt receptor and human disease...
  8. ncbi Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Diabetes 56:2380-7. 2007
    ....
  9. pmc Erythropoietin deficiency decreases vascular stability in mice
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:526-33. 2008
    ..bone marrow-derived progenitor cells and activation of prosurvival NF-kappaB via Epo receptor activation on retinal vessels and neurons...
  10. ncbi Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response
    A Hoover
    Electrical and Computer Engineering Department, Clemson University, SC 29634 0915, USA
    IEEE Trans Med Imaging 19:203-10. 2000
    ..We are making all our images and hand labelings publicly available for interested researchers to use in evaluating related methods...
  11. pmc Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy
    Timothy S Kern
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 5029, USA
    Exp Diabetes Res 2007:95103. 2007
    ..This new hypothesis offers new insight into the pathogenesis of diabetic retinopathy, and offers novel targets to inhibit the ocular disease...
  12. ncbi Revised formulas for summarizing retinal vessel diameters
    Michael D Knudtson
    Department of Ophthalmology, University of Wisconsin, Madison, WI 53726, USA
    Curr Eye Res 27:143-9. 2003
    ....
  13. pmc The mouse retina as an angiogenesis model
    Andreas Stahl
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 51:2813-26. 2010
    ..From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis...
  14. ncbi Development of the mouse retinal vasculature: angiogenesis versus vasculogenesis
    Marcus Fruttiger
    Wolfson Institute for Biomedical Research, University College London, United Kingdom
    Invest Ophthalmol Vis Sci 43:522-7. 2002
    ..These cells are alleged to be vascular precursor cells (angioblasts). This study was designed to test whether such angioblasts exist in neonatal mouse retina...
  15. ncbi Glial reactivity, an early feature of diabetic retinopathy
    E Rungger-Brandle
    Cell Biology Laboratory, University Eye Clinic, Geneva, Switzerland
    Invest Ophthalmol Vis Sci 41:1971-80. 2000
    ..To characterize early structural gliotic reactions in retinal Müller cells, astrocytes, and microglia in experimentally induced diabetes...
  16. ncbi Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes
    Ling Zheng
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Invest Ophthalmol Vis Sci 48:361-7. 2007
    ..The response of the retinal vasculature to an injury (ischemia and reperfusion; I/R) that is known to cause neuronal degeneration was studied...
  17. pmc Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-Ras
    Renu A Kowluru
    Department of Ophthalmology, Kresge Eye Institute, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 51:4320-6. 2010
    ..The goal of this study was to investigate the role of sustained activation of MMP-9 in the pathogenesis of diabetic retinopathy and to illustrate the mechanism through which it is upregulated in diabetes...
  18. pmc Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis
    Denise Stenzel
    Vascular Biology Laboratory, London Research Institute Cancer Research UK, London WC2A 3PX, UK
    Development 138:4451-63. 2011
    ..We propose that in vivo the VEGF-binding properties of FN and HS promote directional tip cell migration, whereas FN integrin-binding functions to support filopodia adhesion to the astrocytic migration template...
  19. ncbi Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 111:1183-90. 2004
    ....
  20. pmc Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia
    Carin Gustavsson
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    PLoS ONE 5:e12699. 2010
    ..Here we investigated the impact of diabetes and dyslipidemia on VCAM-1 expression in mouse retinal vessels, as well as the potential role of tumor necrosis factor-α (TNFα).
  21. pmc Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis
    Kip M Connor
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Protoc 4:1565-73. 2009
    ..In this protocol we describe standards for mouse size, sample size, retinal preparation, quantification of vascular loss, vascular regrowth, NV and neovascular regression...
  22. ncbi Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis
    Matthew T Holderfield
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Circ Res 102:637-52. 2008
    ....
  23. ncbi Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor
    L E Smith
    Department of Ophthalmology, Harvard Medical School and Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Med 5:1390-5. 1999
    ..They also explain why diabetic retinopathy initially increases with the onset of insulin treatment. IGF-1 levels, low in untreated diabetes, rise with insulin therapy, permitting VEGF-induced retinopathy...
  24. pmc Desmin ensheathment ratio as an indicator of vessel stability: evidence in normal development and in retinopathy of prematurity
    Tailoi Chan-Ling
    Department of Anatomy, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Am J Pathol 165:1301-13. 2004
    ..These observations lead us to suggest that a DER of 0.9 represents a vascular stability threshold and that a low DER observed during ROP raises the possibility that mural cell abnormalities play a key role in the pathogenesis of ROP...
  25. ncbi Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels
    René M Werkmeister
    Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
    Opt Lett 33:2967-9. 2008
    ..We demonstrate that bidirectional color Doppler optical coherence tomography allows for the measurement of absolute blood flow values in vivo in human retinal vessels.
  26. ncbi Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations
    Jie Jin Wang
    Centre for Vision Research, Department of Ophthalmology, Westmead Hospital, and the Westmead Millennium Institute, University of Sydney, Australia
    Eur Heart J 28:1984-92. 2007
    ..The retinal microvasculature may reflect pre-clinical changes in the cerebral and coronary microcirculations. We assessed whether smaller retinal arterioles and larger venules predicted coronary heart disease (CHD)- and stroke-mortality...
  27. pmc Meta-analysis: retinal vessel caliber and risk for coronary heart disease
    Kevin McGeechan
    School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    Ann Intern Med 151:404-13. 2009
    ..Retinal vessel caliber may be a novel marker of coronary heart disease (CHD) risk. However, the sex-specific effect, magnitude of association, and effect independent of traditional CHD disease risk factors remain unclear...
  28. ncbi Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes
    Rachel A Feit-Leichman
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:4281-7. 2005
    ..The objective of this study was to characterize the occurrence and pathologic progression of diabetic retinopathy in C57Bl/6J mice...
  29. pmc Functions of the two glutamate transporters GLAST and GLT-1 in the retina
    T Harada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 95:4663-6. 1998
    ..These results demonstrate that GLAST is required for normal signal transmission between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina...
  30. pmc Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures
    Niall Patton
    Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, UK
    J Anat 206:319-48. 2005
    ....
  31. ncbi Circulating bone-marrow-derived endothelial precursor cells contribute to neovascularization in diabetic epiretinal membranes
    Ahmed M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Acta Ophthalmol 89:222-8. 2011
    ..We investigated the presence of bone-marrow-derived endothelial precursor cells and the expression of the chemotactic pathway SDF-1 ⁄CXCL12)CXCR4 in PDR epiretinal membranes...
  32. pmc Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization
    Mohamed Al-Shabrawey
    Department of Oral Biology and Anatomy, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:614-24. 2011
    ..The goal of this study was to investigate whether 12-LOX plays a role in retinal neovascularization (NV)...
  33. ncbi Increased vasodilatory prostaglandin production in the diabetic rat retinal vasculature
    E I Johnson
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Vic, Australia
    Curr Eye Res 18:79-82. 1999
    ..This study was undertaken in order to investigate whether the production of vasodilatory prostaglandins is increased in the retinal vasculature of the diabetic rat...
  34. ncbi Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia
    T S Kern
    Departments of Medicine, Ophthalmology, Pharmacology and Center for Diabetes Research, Case Western Reserve University, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 41:3972-8. 2000
    ..To examine the relationship between early retinal capillary cell apoptosis and late histologic lesions of diabetic retinopathy and to compare the effects of aminoguanidine (AMG) on the retinopathies caused by diabetes and galactose feeding...
  35. ncbi Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement
    Satoshi Arima
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Development 138:4763-76. 2011
    ..in vivo EC-tracking analysis revealed evidence of cell-mixing and overtaking at the tip in developing murine retinal vessels. In parametrical analysis, VEGF enhanced tip cell behavior and directed EC migration at the stalk during ..
  36. pmc Vessel boundary delineation on fundus images using graph-based approach
    Xiayu Xu
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    IEEE Trans Med Imaging 30:1184-91. 2011
    This paper proposes an algorithm to measure the width of retinal vessels in fundus photographs using graph-based algorithm to segment both vessel edges simultaneously...
  37. ncbi Pericytes and the pathogenesis of diabetic retinopathy
    Hans Peter Hammes
    Fifth Medical Clinic, Medical Faculty of the University of Heidelberg, Mannheim, Germany
    Diabetes 51:3107-12. 2002
    ..At high vascular endothelial growth factor levels, such as those in the retinopathy of prematurity model, pericyte deficiency leads to reduced inhibition of endothelial proliferation in vivo...
  38. ncbi Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation
    Christina M Warboys
    Cardiovascular Division, King s College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:1319-28. 2009
    ..Isolated perfused retinas were used to examine the acute effects of AGEs on retinal microvascular permeability...
  39. pmc Neurovascular protective effect of FeTPPs in N-methyl-D-aspartate model: similarities to diabetes
    Mohammed M H Al-Gayyar
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Am J Pathol 177:1187-97. 2010
    ..In addition to acute RGC death, an NMDA model can be a useful tool to study glial activation and capillary degeneration in retinal neurodegenerative disorders, including diabetic retinopathy...
  40. ncbi Comparison of choroidal and retinal endothelial cells: characteristics and response to VEGF isoforms and anti-VEGF treatments
    Elizabeth A Stewart
    University of Nottingham, Division of Ophthalmology and Visual Sciences, B Floor, Eye and ENT Building, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Exp Eye Res 93:761-6. 2011
    ....
  41. ncbi Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification
    João V B Soares
    Institute of Mathematics and Statistics, University of Sao Paulo, 05508 090 Brazil
    IEEE Trans Med Imaging 25:1214-22. 2006
    ..We are making our implementation available as open source MATLAB scripts for researchers interested in implementation details, evaluation, or development of methods...
  42. pmc Inhibition of pathologic retinal neovascularization by alpha-defensins
    Matina Economopoulou
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Rm 4B17, 10 Center Dr, Bethesda, MD 20892, USA
    Blood 106:3831-8. 2005
    ..An up-regulation of beta1-integrin and FN was observed in the retinal vessels in the mouse model of hypoxia-induced retinal angiogenesis...
  43. ncbi Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation
    Wenzheng Hu
    Department of Ophthalmology, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA
    Invest Ophthalmol Vis Sci 49:407-15. 2008
    ..Therefore, VLDLR expression in the wild-type mouse retina was investigated and the retinal angiogenic process in vldlr(-/-) mice was characterized...
  44. ncbi Visually evoked hemodynamical response and assessment of neurovascular coupling in the optic nerve and retina
    Charles E Riva
    Institut de Recherche en Ophtalmologie, 1950 Sion, Switzerland
    Prog Retin Eye Res 24:183-215. 2005
    ....
  45. ncbi Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice
    Mara E Pitulescu
    Department of Tissue Morphogenesis, Faculty of Medicine, Max Planck Institute for Molecular Biomedicine, University of Munster, Munster, Germany
    Nat Protoc 5:1518-34. 2010
    ..These methods have been optimized by our laboratory and yield reliable results. The entire protocol takes approximately 10 d to complete...
  46. pmc Functional characterization of 58-kilodalton inhibitor of protein kinase in protecting against diabetic retinopathy via the endoplasmic reticulum stress pathway
    Hong Yang
    Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People s Republic of China
    Mol Vis 17:78-84. 2011
    ..The aim of this study was to determine the roles of P58(IPK) in protecting against diabetic retinopathy (DR) by inhibiting ER stress-signaling mediators...
  47. pmc The neurovascular retina in retinopathy of prematurity
    Anne B Fulton
    Department of Ophthalmology, Children s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115 5737, USA
    Prog Retin Eye Res 28:452-82. 2009
    ..The data from human subjects and rat models identify photoreceptor and post-receptor targets for interventions that promise improved outcomes for children at risk for ROP...
  48. ncbi Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels
    Magali Saint-Geniez
    Unité INSERM U 397, CHU Rangueil, Toulouse, France
    Mech Dev 110:183-6. 2002
    ..incited us to investigate whether expression of the receptor also increased during the formation of retinal vessels, which occurs postnatally in the mouse...
  49. ncbi Nitric oxide regulates retinal vascular tone in humans
    Guido T Dorner
    Department of Clinical Pharmacology, University of Vienna Medical School, Waehringer Guertel 18 20, Vienna A 1090, Austria
    Am J Physiol Heart Circ Physiol 285:H631-6. 2003
    ..02) in response to flicker stimulation. Our data indicate that NO contributes to basal retinal vascular tone in humans. In addition, NO appears to play a role in flicker-induced vasodilation of the human retinal vasculature...
  50. ncbi Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization
    Candy K Chan
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Lab Invest 85:721-33. 2005
    ..02). Strain-dependent expression of both pro- and antiangiogenic growth factors may determine heterogeneity in the angiogenic response and potentially, susceptibility to angiogenesis-dependent diseases...
  51. pmc The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy
    Chiara Gerhardinger
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Diabetes 58:1659-67. 2009
    ..of diabetic retinopathy would benefit from availability of drugs that preempt the effects of hyperglycemia on retinal vessels. We aimed to identify candidate drug targets by investigating the molecular effects of drugs that prevent ..
  52. ncbi Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase
    Arthur H Neufeld
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, St Louis, MO 63110, USA
    Exp Eye Res 75:521-8. 2002
    ..Continuous pharmacological treatment with inhibitors of NOS-2 activity during the 2 weeks post-ischemia period provides significant neuroprotection against the loss of RGCs...
  53. ncbi Recruitment of pericytes and astrocytes is closely related to the formation of tight junction in developing retinal vessels
    Jeong Hun Kim
    Department of Ophthalmology, Seoul National University College of Medicine and Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    J Neurosci Res 87:653-9. 2009
    ..Subsequently, retinal vessels sprout into the deep retinal layer to form three parallel of the nerve fiber layer and two plexiform layers...
  54. ncbi Retardation of retinal vascular development in apelin-deficient mice
    Atsushi Kasai
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, OsakaUniversity, Japan
    Arterioscler Thromb Vasc Biol 28:1717-22. 2008
    ..Apelin is an endogenous ligand for the G protein-coupled receptor, APJ, and participates in multiple physiological processes. To identify the roles of endogenous apelin, we investigated the phenotype of apelin-deficient (apelin-KO) mice...
  55. pmc High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs
    Qiong Huang
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53792 4673, USA
    Am J Physiol Cell Physiol 295:C1647-57. 2008
    ..Thus alterations in the proangiogenic properties of retinal EC during diabetes may contribute to the development and pathogenesis of diabetic retinopathy...
  56. ncbi Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk In Communities study
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 45:2949-54. 2004
    ..To examine the cross-sectional relationship of the metabolic syndrome (hypertension, hyperglycemia, central obesity, and dyslipidemia) and retinal microvascular abnormalities in middle-aged men and women...
  57. ncbi Use of laser speckle flowgraphy in ocular blood flow research
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Japan
    Acta Ophthalmol 88:723-9. 2010
    ..Unresolved issues concern the effect of pupil size on measurement results, the effects of various stimulations, and how to measure choroidal and retinal blood flow velocity separately without using the blue-component of argon laser...
  58. pmc Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure
    B Chang
    The Howard Hughes Medical Institute, USA
    BMC Genet 2:18. 2001
    ..Bone morphogenetic proteins (BMPs) participate in various developmental processes. We tested the importance of Bmp4 gene dosage for ocular development and developmental glaucoma...
  59. pmc Alterations in retinal microvascular geometry in young type 1 diabetes
    Muhammad Bayu Sasongko
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
    Diabetes Care 33:1331-6. 2010
    ..To describe retinal microvascular geometric parameters in young patients with type 1 diabetes...
  60. ncbi Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina
    Michael I Dorrell
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd MB216, La Jolla, CA 92037, USA
    Prog Retin Eye Res 25:277-95. 2006
    ....
  61. pmc Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 50:1329-35. 2009
    ..The authors investigated the inhibition of retinal EPO mRNA expression with RNA interference as a potential strategy to suppress retinal neovascularization and to prevent proliferative retinopathy...
  62. pmc Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy
    Bin Li
    Key Laboratory of Ophthalmology of the Ministry of Education and Zhong Shan Ophthalmic Center, Sun Yet Sun University, Guangzhou City, People s Republic of China
    Mol Vis 15:861-9. 2009
    ..We performed human, animal, and in vitro studies to examine the potential role of nuclear transport factor 2 (NTF2) in conferring resistance to diabetic retinopathy (DR)...
  63. ncbi Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway
    Jaetaek Kim
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Chung Ang University, 224 1 Heuk Seok dong, Dongjak Ku, Seoul 156 755, South Korea
    Exp Eye Res 84:886-93. 2007
    ..Thus fenofibrate may have a novel therapeutic property that can control unwanted cell death found in diabetic retinopathy...
  64. ncbi Retinal vessel diameters and risk of hypertension: the Rotterdam Study
    M Kamran Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 47:189-94. 2006
    ..quot; Within these strata, arteriolar narrowing was still related to incident hypertension. These data show that both retinal arteriolar and venular narrowing may precede the development of systemic hypertension...
  65. ncbi Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
    Timothy S Kern
    Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Diabetes 56:373-9. 2007
    ..Local inhibition of inflammatory pathways in the eye offers a novel therapeutic approach toward inhibiting the development of lesions of diabetic retinopathy...
  66. ncbi Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate
    Michael J Tolentino
    F M Kirby Center for Molecular Ophthalmology and Retina Service, Scheie Eye Institute University of Pennsylvania, Philadelphia, USA
    Am J Ophthalmol 133:373-85. 2002
    ..The purpose of this study was to further characterize the angiopathic changes that occur after intravitreal injections in a nonhuman primate and determine if preretinal neovascularization develops...
  67. ncbi Long-term effect of intravitreal bevacizumab (avastin) in patients with chronic diffuse diabetic macular edema
    Daniel Kook
    From the Department of Ophthalmology, Ludwig Maximilians Universitat, Munich, Germany
    Retina 28:1053-60. 2008
    ..To evaluate the long-term efficacy of bevacizumab for the treatment of chronic diffuse diabetic macular edema after various previous treatments...
  68. ncbi Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy
    Jing Zhang
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Diabetes 51:3499-504. 2002
    ..In this study, we observed deposition of C5b-9, the terminal product of complement activation, in the wall of retinal vessels of human eye donors with 9 +/- 3 years of type 2 diabetes, but not in the vessels of age-matched nondiabetic ..
  69. ncbi Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830 0011, Japan
    J Biol Chem 281:20213-20. 2006
    ..Substitution of PEDF may offer a promising strategy for halting the development of diabetic retinopathy...
  70. ncbi Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy
    Shigeru Yatoh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Diabetes Metab Res Rev 22:38-45. 2006
    ..Therefore, we investigated apoptosis of RMCs in Goto-Kakizaki (GK) rats, a type 2 diabetic model, and involvement with antioxidants (a combination of vitamins C and E) or a novel inhibitor of advanced glycation, OPB-9195...
  71. ncbi The retinal vasculature and function of the neural retina in a rat model of retinopathy of prematurity
    Kegao Liu
    Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 47:2639-47. 2006
    ..In a rat model of retinopathy of prematurity (ROP), the retinal vasculature and function of the neural retina were studied longitudinally. Vascular and neural parameters were evaluated for significant relationships...
  72. pmc Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells
    Atsushi Otani
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 114:765-74. 2004
    ....
  73. ncbi Classification and management of Coats disease: the 2000 Proctor Lecture
    J A Shields
    Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Ophthalmol 131:572-83. 2001
    ..However, poor visual outcome of 20/200 or worse commonly results. Patients who present with stages 1 to 3 Coats disease have the best visual prognosis, and patients with stages 4 and 5 have a poor visual prognosis...
  74. pmc LRP5 is required for vascular development in deeper layers of the retina
    Chun hong Xia
    School of Optometry and Vision Science Program, University of California, Berkeley, California, USA
    PLoS ONE 5:e11676. 2010
    ....
  75. pmc Retinal vessel diameters and risk of hypertension: the Multiethnic Study of Atherosclerosis
    Ryo Kawasaki
    Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
    J Hypertens 27:2386-93. 2009
    ..To describe the prospective relationship of retinal vessel diameters with risk of hypertension in a multiethnic population-based cohort...
  76. ncbi Response of retinal vessels and retrobulbar hemodynamics to intravitreal anti-VEGF treatment in eyes with branch retinal vein occlusion
    Stefan Sacu
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 52:3046-50. 2011
    ..To investigate whether intravitreal ranibizumab (0.05 mL) treatment affects retinal vessel diameters and retrobulbar blood velocities in patients with acute branch retinal vein occlusion (BRVO)...
  77. pmc Corkscrew retinal vessels in neurofibromatosis type 1: report of 12 cases
    R Muci-Mendoza
    Neuro Ophthalmology Unit, Hospital Vargas de Caracas, José María Vargas School of Medicine, Central University of Venezuela
    Br J Ophthalmol 86:282-4. 2002
    ..To describe a distinctive spectrum of retinal microvascular abnormalities in 12 patients with neurofibromatosis type 1 (NF-1)...
  78. ncbi Rigidity of retinal vessel in untreated eyes of normal tension primary open-angle glaucoma patients
    Alexander Oettli
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    J Glaucoma 20:303-6. 2011
    ..To analyze pulse wave propagation in the ocular circulation and vessel stiffness in untreated eyes of normal tension primary open-angle glaucoma (NTG) patients...
  79. pmc Microvascular patterning is controlled by fine-tuning the Akt signal
    Jing Fang Sun
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:128-33. 2005
    ....
  80. ncbi Retinal vessel analysis in hypercholesterolemic patients before and after LDL apheresis
    Manja Reimann
    Autonomic and Neuroendocrinological Laboratory, Dept of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Germany
    Atheroscler Suppl 10:39-43. 2009
    ..Using retinal vascular imaging techniques, we attempted to investigate the microvascular benefit of a single LDL apheresis in hypercholesterolemia...
  81. ncbi Hyperspectral imaging for measurement of oxygen saturation in the optic nerve head
    Bahram Khoobehi
    LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 45:1464-72. 2004
    ..To evaluate a hyperspectral imaging technique for monitoring relative spatial changes in retinal oxygen saturation...
  82. pmc Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy
    Mohamed Al-Shabrawey
    Vascular Biology Center, Medical College of Georgia, 1120 15th St, Augusta, GA 30912 2500, USA
    Am J Pathol 167:599-607. 2005
    ..In conclusion, NAD(P)H oxidase activity is required for hypoxia-stimulated increases in VEGF expression and retinal neovascularization. Inhibition of NAD(P)H oxidase offers a new therapeutic target for the treatment of retinopathy...
  83. ncbi Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice
    Chatarina Lofqvist
    Department of Ophthalmology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Invest Ophthalmol Vis Sci 50:1831-7. 2009
    ..Retinopathy is a result of pathologic angiogenesis influenced by insulinlike growth factor (IGF)-1. The authors examined the local expression of the IGF/insulin family...
  84. ncbi Clinical variations and complications of Coats disease in 150 cases: the 2000 Sanford Gifford Memorial Lecture
    J A Shields
    Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Ophthalmol 131:561-71. 2001
    ..The clinician should follow strict criteria in making the diagnosis, to avoid confusing Coats disease with other forms of exudative retinopathy...
  85. ncbi Central retinal artery occlusion. Retinal survival time
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 55242 1091, USA
    Exp Eye Res 78:723-36. 2004
    ..To investigate the retinal survival time following central retinal artery occlusion (CRAO)...
  86. ncbi Retinal vasculature changes in Norrie disease mice
    M Richter
    Department of Anatomy II, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 39:2450-7. 1998
    ..To correlate morphologic changes in the retinal vasculature with degenerative changes in the neuronal retina of mice lacking 56 amino acids from the N-terminus of the Norrie disease (ND) gene product...
  87. ncbi Cerebral white matter lesions, retinopathy, and incident clinical stroke
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, USA
    JAMA 288:67-74. 2002
    ..White matter lesions (WMLs) detected on cerebral imaging scans have been hypothesized to have a microvascular etiology and to precede the development of clinical stroke. However, few clinical data are available to support these hypotheses...
  88. ncbi Genetic influences on susceptibility to oxygen-induced retinopathy
    Peter van Wijngaarden
    Department of Ophthalmology, Flinders University of South Australia, Flinders Medical Centre, Adelaide, Bedford Park, 5042 SA, Australia
    Invest Ophthalmol Vis Sci 48:1761-6. 2007
    ..To investigate the inheritance of susceptibility to oxygen-induced retinopathy in the rat with the use of formal backcross analysis...
  89. ncbi Inhibition of protein kinase C is not sufficient to prevent or reverse effects of VEGF165 on claudin-1 and permeability in microvascular retinal endothelial cells
    Heidrun L Deissler
    Department of Ophthalmology, University of Ulm Medical School, Ulm, Germany
    Invest Ophthalmol Vis Sci 51:535-42. 2010
    ..This study was conducted to investigate whether the VEGF(165)-induced loss of claudin-1 is regulated by protein kinase C (PKC) and indeed affects the barrier function of iBRECs...
  90. ncbi Kinetics of retinal vaso-obliteration and neovascularisation in the oxygen-induced retinopathy (OIR) mouse model
    C Lange
    Laboratory for Cell Biology, University Eye Hospital, 79106 Freiburg, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1205-11. 2009
    ....
  91. ncbi Mouse model of subretinal neovascularization with choroidal anastomosis
    John R Heckenlively
    Jules Stein Eye Institute, UCLA School of Medicine, University of California at Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 23:518-22. 2003
    ..To characterize the phenotype and report a reliable genetic model of retinal angiogenesis and subretinal neovascularization in the mouse...
  92. pmc Mediators of ocular angiogenesis
    Yureeda Qazi
    Department of Ophthalmology, John Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    J Genet 88:495-515. 2009
    ....
  93. ncbi Retinal vascular imaging: a new tool in microvascular disease research
    Gerald Liew
    Centre for Vision Research, Department of Ophthalmology, University of Sydney, Westmead Hospital, Hawkesbury Road, Westmead, NSW 2145, Australia
    Circ Cardiovasc Imaging 1:156-61. 2008
    ..Key areas where retinal vascular imaging has contributed to increased understanding of microvascular pathology and major areas of current and new research are discussed in this review...
  94. pmc Retinal microvascular abnormalities and cognitive decline: the ARIC 14-year follow-up study
    S R Lesage
    University of Maryland Medical Center, Department of Neurology, 22 S Greene St, Baltimore, MD 21201, USA
    Neurology 73:862-8. 2009
    ..To better understand the role of SVD in cognitive function, we investigated the relationship between retinal microvascular abnormalities and longitudinal changes in cognitive function in a community-based study...
  95. ncbi Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?
    T M Curtis
    Centre for Vision and Vascular Science, The Royal Victoria Hospital, Institute of Clinical Sciences, The Queen s University of Belfast, Belfast, UK
    Eye (Lond) 23:1496-508. 2009
    ..In the current review a unifying framework is presented that explains how arteriolar dysfunction and haemodynamic changes may contribute to late stage microvascular pathology and vision loss in human diabetic retinopathy...
  96. ncbi Histopathology of the human retina in retinitis pigmentosa
    A H Milam
    Department of Ophthalmology, University of Washington, Seattle 98195 6485, USA
    Prog Retin Eye Res 17:175-205. 1998
    ....
  97. pmc The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model
    Grace Byfield
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7041, USA
    Invest Ophthalmol Vis Sci 50:3360-5. 2009
    ....
  98. ncbi Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Eye Res 18:20-7. 1999
    ....
  99. pmc The role of PGE2 receptor EP4 in pathologic ocular angiogenesis
    Susan E Yanni
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 50:5479-86. 2009
    ....
  100. ncbi Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1
    Nicholas W Gale
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Dev Cell 3:411-23. 2002
    ..Our studies define a vascular growth factor whose primary role is in postnatal angiogenic remodeling and also demonstrate that members of the VEGF and Angiopoietin families collaborate during development of the lymphatic vasculature...
  101. ncbi Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 46:2925-31. 2005
    ..To examine whether the angiotensin II type 1 receptor (AT1-R) signaling plays a role in ocular inflammation in endotoxin-induced uveitis (EIU)...

Research Grants66

  1. Retinal Vascular Changes in Type 1 Diabetic African-Americans
    Monique Roy; Fiscal Year: 2007
    ..Of the original cohort of 725 African-American patients, 709 (97.8%) had gradable (i.e., with measurable retinal vessels) baseline retinal photographs. Of these 709, 580 (81...
  2. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
    ..whether, BM-derived CD34+ cells, when primed with the N- terminal domains of Cyr61, integrate into damaged retinal vessels and improve vascular recovery...
  3. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..Our long term goal is to provide clinical comprehensive functional and anatomical assessment of retinal vessels in humans...
  4. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..We will measure fluorescence due to atherosclerosis-associated mediators in the retinal vessels, and correlate their expression with expression in other inaccessible but major arteries in the body, which ..
  5. Regulation and Function of the Matricellular Protein CCN1 in Ischemic Retinopathy
    Brahim Chaqour; Fiscal Year: 2013
    ..This proposal will provide new insights into the molecular mechanisms of CCN1 activities in vivo and may foster future safer, less destructive, and more effective therapies to harness ischemia-induced neovascularization in ROP. ..
  6. Sphingosine 1-Phosphate: A New Target for Early Diabetic Retinopathy
    Arup Das; Fiscal Year: 2013
    ..It is not known how this pericyte change in diabetes further leads to increased vaso-permeability in retinal vessels. In new and exciting findings, we have shown that pericytes can regulate the expression of N- cadherin in ..
  7. Diabetic retinopathy: sigma receptor 1 (??R1) as a novel therapeutic target.
    Sylvia B Smith; Fiscal Year: 2013
    ..It is a neurovascular disease characterized by alterations of retinal vessels and death of retinal neurons...
  8. Dietary control of angiogenesis in retinopathy models
    Lois Smith; Fiscal Year: 2013
    ..Retinopathy is characterized by inflammation and affects both retinal vessels and neurons. Lipids modulate inflammation and influence angiogenesis and neuroprotection...
  9. The control of retinal vascular development by Norrin and Frizzled4
    Jeremy Nathans; Fiscal Year: 2013
    ..1 ..
  10. The Role of the Nicotinic Cholinergic Pathway in Retinopathy of Prematurity
    John P Cooke; Fiscal Year: 2013
    ..We will study EC from normal retinal vessels using laser capture microdissection and real time RT-PCR, in situ hybridization and immunohistochemistry...
  11. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
    ..available SDOCT imaging systems to provide the additional functionality of high resolution imaging of retinal vessels and choroidal neovascularization...
  12. Mechanisms of Diabetic Retinopathy: Oxidative Stress and Inflammation
    Ruth B Caldwell; Fiscal Year: 2013
    ..to identify cellular and molecular sources of dysregulated ROS, define their specific role in damaging the retinal vessels and evaluate potential therapies for blocking/reversing the injury...
  13. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..morpholino oligomers (PMO) to TGF-b1 in diabetic CD34+HSC will potentiate their ability to repair retinal vessels in diabetes...
  14. Adipose Stem Cells for Diabetic Retinopathy
    SHAYN PEIRCE-COTTLER; Fiscal Year: 2013
    ..capable of becoming functional pericytes in vitro;Aim 2: Determine the capacity of hASCs to stabilize retinal vessels against acute (OIR) and chronic (STZ &Akimba) vascular insults;Aim 3: Determine the capacity of hASCs to ..
  15. Vasculogenesis and hyperoxia in the developing retina.
    GERARD ANTHONY LUTTY; Fiscal Year: 2013
    ....
  16. Validation and development of specific small molecule inhibitors of HTRA1 for tre
    Shuyuan Yao; Fiscal Year: 2010
    ..proteases and is expressed in the retina, retinal pigment epithelium and in the endothelium of pathologic retinal vessels. Dr. Kang Zhang Lab has generated polyclonal and monoclonal antibodies against human HTRA1...
  17. A novel bA3/A1-crystallin gene mutation results in persistent fetal vasculature
    Debasish Sinha; Fiscal Year: 2013
    ..Astrocytes migrate from the optic nerve into the inner retina to form a template on which the retinal vessels will develop...
  18. Retinal Nerve Fiber Layer Area in Aging and Glaucoma
    NIMESH BHIKHU PATEL; Fiscal Year: 2013
    ..Although glial tissue and small retinal vessels cannot be visualized in SD-OCT scans, the major retinal vessels cast shadows on the underlying tissues, and ..
  19. The roles of Frizzled-4 and Sox17 in retinal vascular development and maintenance
    MAX TISCHFIELD; Fiscal Year: 2013
    ..abstract_text> ..
  20. Mechanisms of action of drugs that prevent experimental diabetic retinopathy
    Mara Lorenzi; Fiscal Year: 2012
    ..from drugs that prevent experimental diabetic retinopathy which molecular processes must be silenced in the retinal vessels in order to prevent the sight-threatening damage induced by diabetes...
  21. Dark adaptation and hypoxia in diabetic retinopathy
    Eric A Newman; Fiscal Year: 2013
    ..However, the initial factors leading to development of the disease remain unclear. Blood flow in retinal vessels is compromised in early stages of diabetic retinopathy...
  22. Automated retinopathy of prematurity classification using machine learning
    Jayashree Kalpathy-Cramer; Fiscal Year: 2013
    ..will be tested using two Specific Aims: (1) Develop and evaluate semi-automated algorithms to segment retinal vessels and generate a set of retinal vessel-based features...
  23. Retinovascular pathophysiology: focus on proliferative retinopathy
    Donald G Puro; Fiscal Year: 2013
    ..To begin characterization of the functional interactions of pre- and intra-retinal vessels, we preformed preliminary studies utilizing a well-established mouse model of proliferative retinopathy...
  24. Light regulated vascular development of the eye
    Richard A Lang; Fiscal Year: 2013
    ..abnormal vascular development in which the regression of hyaloid vessels is retarded and the growth of retinal vessels is promiscuous. The same abnormal growth is observed in light reared mice lacking the photopigment melanopsin...
  25. HISTAMINE CONTAINING CENTRIFUGAL AXONS IN THE RETINA
    David Marshak; Fiscal Year: 2000
    ..If this is correct, there may be a morphological correlate of this increased activity. The human material will also be studied using the electron microscopic technique developed in the first set of experiments. ..
  26. EARLY TMT/RETINOPATHY OF PREMATURITY (ETROP)- COORD CTR
    Robert Hardy; Fiscal Year: 2009
    ..Outcome will be determined at a 6 month post-term ophthalmologic examination and at a 9 month post-term visual assessment examination. ..
  27. CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MO
    Bela Anand Apte; Fiscal Year: 2007
    ..Retinal neovascularization involves the development of sprouts from retinal vessels, which usually penetrates the inner limiting membrane (ILM) and grows into the vitreous...
  28. A CRYSTALLIN MUTATION WITH ABNORMAL ASTROCYTES AND RETINAL VESSELS
    Debasish Sinha; Fiscal Year: 2010
    ..In homozygous Nuc1 rats the fetal intraocular vessels persist even after development of the retinal vessels. During early post-natal development these rats also have a much thicker retina than normal with an excess ..
  29. Retinal blood barrier permeability using optical tracers
    FREDERICK HASELTON; Fiscal Year: 2004
    ..instrumentation and image analysis techniques for the simultaneous measurement of two fluorescent tracers in retinal vessels. And thirdly, we plan to develop mathematical models for the identification of retinal microcirculatory ..
  30. SODIUM MRI & CSI OF EXPERIMENTAL DIABETIC RETINOPATHY
    NANCY KOLODNY; Fiscal Year: 1990
    ..These parameters will provide insight into the changing nature of the vitreous gel associated with diabetic retinopathy...
  31. ADENOSINE RECEPTORS TO INHIBIT RETINAL ANGIOGENESIS
    Luiz Belardinelli; Fiscal Year: 2000
    ..These diseases are characterized by neovascularization that results from ischemic injury to retinal vessels, i.e., compensatory angiogenesis...
  32. GROWTH FACTOR INDUCED TENASCIN C IN DIABETIC RETINOPATHY
    Alexander Ljubimov; Fiscal Year: 2000
    ..3) To attempt to block the VEGF induce migration and angiogenesis in retinal endothelial cultures using neutralizing antibodies to tenascin-C and its binding integrins. ..
  33. ELECTRORETINOGRAM IN BACKGROUND DIABETIC RETINOPATHY
    GLORIA WU; Fiscal Year: 1991
    ..The function of the photoreceptor (a-wave) and inner retina nourished by the retinal vessels (b-wave and oscillatory potential) may be examined by using the ERG...
  34. Thickening of basement membrane in diabetic retinopathy
    Sayon Roy; Fiscal Year: 2007
    ..The hypothesis is based on recent findings that human retinal vessels manifest alterations that can be induced by the thickened BMs and, in turn, can compromise the integrity of ..
  35. MODELING THE NATURAL HISTORY OF DIABETIC RETINOPATHY
    Bruce Craig; Fiscal Year: 1999
    ..We will investigate several difference screening and treatment programs for each type of diabetes. ..
  36. Surrogate Markers for Early Stage Diabetic Retinopathy
    Lois Smith; Fiscal Year: 2003
    ....
  37. PERMEABILITY OF RETINAL VESSELS: CYTOCHEMICAL STUDIES
    EDWARD ESSNER; Fiscal Year: 1992
    ..Results will be quantified using morphometric analysis. Finally, the endothelial cytoskeleton will be examined in normal arteriolar endothelial cells and in those of spontaneously, hypertensive-stroke prone rats. ..
  38. Optic Nerve Head Analyzer for Glaucoma
    GILBERTO ZAMORA; Fiscal Year: 2004
    ..can provide quantitative information for the changes in structure and configuration of the optic disc and retinal vessels and thus has the potential to advance the diagnostic techniques and time to diagnosis for glaucoma...
  39. Retinal Vessel Measurement and Characterization System
    Mark Wilson; Fiscal Year: 2003
    ..We propose to develop and validate a system that extracts retinal vessels, classifies their bifurcations and crossings, and quantifies a diameter measurement of the retinal vas-..
  40. DIABETIC METABOLIC CONTROL AND RETINAL BLOOD FLOW
    Juan Grunwald; Fiscal Year: 1991
    ..noninvasive techniques: Laser Boppler Velocimetry which provides measurements of the circulation in the main retinal vessels and Blue Field Simulation which enables the study of the retinal microcirculation in the macular areas...
  41. HUMAN RETINAL BLOOD FLOW AND LASER VELOCIMETRY
    GILBERT FEKE; Fiscal Year: 1991
    ..technique that can measure instantaneous changes in the velocity of red blood cells flowing in individual retinal vessels, a requirement for the complete characterization of retinal hemodynamics...
  42. Retinal Microvascular Signs and CVD in Older Persons
    Tien Wong; Fiscal Year: 2005
    ..This may ultimately lead to improved identification, and preventive and therapeutic strategies for the most common causes of morbidity, disability and mortality affecting elderly people in the United States. ..
  43. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2002
    ....
  44. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  45. Retinal Microvascular Characteristics/Vascular Disorders
    Ronald Klein; Fiscal Year: 2003
    ..abstract_text> ..
  46. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2005
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  47. Microvascular - Macrovascular Disease in Type 2 Diabetes
    Ronald Klein; Fiscal Year: 2005
    ....
  48. Novel Risk Factors for Chronic Kidney Disease
    Ronald Klein; Fiscal Year: 2008
    ..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
  49. Investigating the Molecular Mechanism of Hexose-induced Stress in Lens and Retina
    Peter F Kador; Fiscal Year: 2010
    ..Moreover, these studies should help identify new drug targets for the treatment of these diabetic complications. ..
  50. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  51. The Predictive Value of Pre-plus Disease in ROP
    David Wallace; Fiscal Year: 2008
    ..abstract_text> ..
  52. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
  53. Multifunctional Antioxidants as Anti-Cataract Agents
    Peter Kador; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  54. Nanoparticle delivery of antiangiogenic genes
    Gerard Lutty; Fiscal Year: 2003
    ..The goal of this proposal is to deliver genes for endogenous antiangiogenic agents to sites of ocular neovascularization. ..
  55. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  56. MEDIATORS OF BLOOD-RETINAL BARRIER BREAKDOWN
    STANLEY VINORES; Fiscal Year: 2002
    ....
  57. HIGH GLUCOSE, DNA, AND DIABETIC COMPLICATIONS
    Mara Lorenzi; Fiscal Year: 2002
    ..Having observed in both human and experimental diabetes accelerated apoptosis of the cells of retinal vessels - pericytes and endothelial cells - we sought to identify relevant molecular events...
  58. Role of Retinal Microvasculature in Posterior Uveitis
    Justine Smith; Fiscal Year: 2006
    ..The studies should also have implications for unrelated diseases affecting the retinal circulation, as well as tissue-specific inflammations and infections at other body sites. [unreadable] [unreadable]..
  59. Retinal Image Quality in Retinal-diseased Eyes
    Mahnaz Shahidi; Fiscal Year: 2010
    ....
  60. Regulation of Angiogenesis via EphB4 Signaling
    JENA STEINLE; Fiscal Year: 2002
    ..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
  61. Retinopathy in Chronic Renal Insufficiency
    Juan E Grunwald; Fiscal Year: 2010
    ....
  62. OCULAR HEMODYNAMICS IN GLAUCOMA
    Juan Grunwald; Fiscal Year: 2001
    ..If hemodynamic abnormalities are present, then attention can be focused on altering the optic nerve circulation as a means of treating glaucoma. ..