venules

Summary

Summary: The minute vessels that collect blood from the capillary plexuses and join together to form veins.

Top Publications

  1. pmc Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules
    Espen S Baekkevold
    Laboratory for Immunohistochemistry and Immunopathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Am J Pathol 163:69-79. 2003
  2. ncbi Lymphocyte trafficking across high endothelial venules: dogmas and enigmas
    Masayuki Miyasaka
    Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita 565 0871, Japan
    Nat Rev Immunol 4:360-70. 2004
  3. ncbi Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 111:1183-90. 2004
  4. ncbi Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
    Konstantin Stark
    Medizinische Klinik und Poliklinik I, Klinikum der Universitat, Ludwig Maximilians Universität and Deutsches Herzzentrum München, Technische Universitat Munchen, Munich, Germany
    Nat Immunol 14:41-51. 2013
  5. ncbi Synchrony of high endothelial venules and lymphatic vessels revealed by immunization
    Shan Liao
    Department of Epidemiology and Public Health and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 177:3369-79. 2006
  6. pmc Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo
    U H von Andrian
    La Jolla Institute for Experimental Medicine, CA 92037
    Proc Natl Acad Sci U S A 88:7538-42. 1991
  7. ncbi Retinal oximetry images must be standardized: a methodological analysis
    Olafur Palsson
    University of Iceland, National University Hospital, Reykjavik, Iceland
    Invest Ophthalmol Vis Sci 53:1729-33. 2012
  8. ncbi Diabetic patients with retinopathy show increased retinal venous oxygen saturation
    Martin Hammer
    Department of Ophthalmology, University of Jena, Bachstr 18, 07740, Jena, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1025-30. 2009
  9. pmc Conditional gene targeting in mouse high endothelial venules
    Hiroto Kawashima
    Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Immunol 182:5461-8. 2009
  10. ncbi Perivascular cells along venules upregulate NG2 expression during microvascular remodeling
    Walter L Murfee
    Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, Virginia 22908, USA
    Microcirculation 13:261-73. 2006

Detail Information

Publications239 found, 100 shown here

  1. pmc Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules
    Espen S Baekkevold
    Laboratory for Immunohistochemistry and Immunopathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Am J Pathol 163:69-79. 2003
    ..by multi-step interactions between the circulating cells and the specialized endothelium of high endothelial venules (HEVs)...
  2. ncbi Lymphocyte trafficking across high endothelial venules: dogmas and enigmas
    Masayuki Miyasaka
    Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita 565 0871, Japan
    Nat Rev Immunol 4:360-70. 2004
  3. ncbi Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 111:1183-90. 2004
    ....
  4. ncbi Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
    Konstantin Stark
    Medizinische Klinik und Poliklinik I, Klinikum der Universitat, Ludwig Maximilians Universität and Deutsches Herzzentrum München, Technische Universitat Munchen, Munich, Germany
    Nat Immunol 14:41-51. 2013
    ..and capillary pericytes attracted and interacted with myeloid leukocytes after extravasating from postcapillary venules, 'instructing' them with pattern-recognition and motility programs...
  5. ncbi Synchrony of high endothelial venules and lymphatic vessels revealed by immunization
    Shan Liao
    Department of Epidemiology and Public Health and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 177:3369-79. 2006
    The mature phenotype of peripheral lymph node (LN) high endothelial venules (HEVs), defined as MAdCAM-1(low) PNAd(high) LTbetaR(high) HEC-6ST(high), is dependent on signaling through the lymphotoxin-beta receptor (LTbetaR)...
  6. pmc Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo
    U H von Andrian
    La Jolla Institute for Experimental Medicine, CA 92037
    Proc Natl Acad Sci U S A 88:7538-42. 1991
    ..have compared the effect of antibodies against LECAM-1 and CD18 on leukocyte interactions with rabbit mesenteric venules. Anti-LECAM-1 monoclonal antibody and its Fab fragments inhibited initial reversible leukocyte rolling along the ..
  7. ncbi Retinal oximetry images must be standardized: a methodological analysis
    Olafur Palsson
    University of Iceland, National University Hospital, Reykjavik, Iceland
    Invest Ophthalmol Vis Sci 53:1729-33. 2012
    ..We determine (1) the repeatability of retinal vessel oxygen saturation measurements, (2) whether measured saturation is different between retinal quadrants, and (3) whether the angle of gaze changes measurements of the same vessels...
  8. ncbi Diabetic patients with retinopathy show increased retinal venous oxygen saturation
    Martin Hammer
    Department of Ophthalmology, University of Jena, Bachstr 18, 07740, Jena, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1025-30. 2009
    ..Longstanding diabetes mellitus results in a disturbed microcirculation. A new imaging oximeter was used to investigate the effect of this disturbance on retinal vessel oxygen saturation...
  9. pmc Conditional gene targeting in mouse high endothelial venules
    Hiroto Kawashima
    Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Immunol 182:5461-8. 2009
    High endothelial venules (HEVs) are specialized blood vessels of secondary lymphoid organs composed of endothelial cells with a characteristic cuboidal morphology...
  10. ncbi Perivascular cells along venules upregulate NG2 expression during microvascular remodeling
    Walter L Murfee
    Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, Virginia 22908, USA
    Microcirculation 13:261-73. 2006
    ..neuron-glial antigen 2 (NG2) is expressed by perivascular cells along arterioles and capillaries, but not along venules in quiescent rat mesenteric microvascular networks...
  11. pmc Shedding of the endothelial glycocalyx in arterioles, capillaries, and venules and its effect on capillary hemodynamics during inflammation
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, University Park, 16802, USA
    Am J Physiol Heart Circ Physiol 301:H2235-45. 2011
    ..reductions in thickness of the barrier to 70-kDa dextran of 110, 80, and 123 nm, in arterioles, capillaries, and venules, respectively...
  12. ncbi Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII
    Laura Piccio
    Department of Pathology, University of Verona, Verona, Italy
    J Immunol 174:5805-13. 2005
    ..However, the mechanisms controlling the recruitment of lymphocytes to the CNS via inflamed brain venules are poorly understood, and therapeutic approaches to inhibit this process are consequently few...
  13. pmc VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation
    Sung Hee Chang
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 69:4537-44. 2009
    ..form are greatly enlarged, pericyte-poor sinusoids, called mother vessels (MV), that originate from preexisting venules. We postulated that the venular enlargement necessary to form MV would require a selective degradation of their ..
  14. ncbi Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules: its implications in lymphocyte trafficking
    Bo Gie Yang
    Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Immunol 179:4376-82. 2007
    Certain lymphoid chemokines are selectively and constitutively expressed in the high endothelial venules (HEV) of lymph nodes and Peyer's patches, where they play critical roles in the directional migration of extravasating lymphocytes ..
  15. ncbi The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
    J J Campbell
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Nature 400:776-80. 1999
    ..Immunohistochemistry reveals anti-TARC reactivity of venules and infiltration of many CCR4+ lymphocytes in chronically inflamed skin, but not in the gastrointestinal lamina ..
  16. ncbi LYVE-1 expression on high endothelial venules (HEVs) of lymph nodes
    T Wrobel
    Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw Poland
    Lymphology 38:107-10. 2005
    ..High endothelial venules (HEVs) belong to the vascular compartment of lymph nodes...
  17. pmc Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo
    U Jung
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Invest 102:1526-33. 1998
    ..TNF-alpha- treated CD18 null mouse cremaster muscle venules show increased leukocyte rolling velocity and reduced leukocyte recruitment efficiency...
  18. ncbi Evidence of arteriolar narrowing in low-birth-weight children
    Paul Mitchell
    Centre for Vision Research, Department of Ophthalmology, University of Sydney, Westmead Hospital, Hawkesbury Rd, Westmead, New South Wales, Australia
    Circulation 118:518-24. 2008
    ..We hypothesized that poor in utero growth is associated with narrower arteriolar caliber, which may help explain the established association of low birth weight with hypertension and cardiovascular disease in adulthood...
  19. ncbi RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo
    David Frommhold
    Section of Neonatal Medicine, University of Heidelberg, Heidelberg, Germany
    Blood 116:841-9. 2010
    ..We show that trauma-induced leukocyte adhesion in cremaster muscle venules is strongly dependent on RAGE and ICAM-1 acting together in an overlapping fashion...
  20. ncbi IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation
    Anne Krug
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:6079-83. 2002
    ..cells (IPC) circulate in the blood and cluster in chronically inflamed lymph nodes around high endothelial venules (HEV)...
  21. ncbi Branching patterns for arterioles and venules of the human cerebral cortex
    Francis Cassot
    Functional Neuroimaging Laboratory, INSERM U825, CHU Purpan, 31059 Toulouse Cedex 3, France
    Brain Res 1313:62-78. 2010
    ..A novel segmentation method was used to extract the skeletons of 228 vascular trees (152 arterioles and 76 venules) and measure the diameter at every vertex...
  22. ncbi 2011 Young Surgeon's Award Winner: high endothelial venules: a novel prognostic marker in cancer metastasis and the missing link?
    Ser Yee Lee
    Department of General Surgery, Singapore General Hospital, Singapore
    Ann Acad Med Singapore 41:21-8. 2012
    ..sentinel LN before the arrival of cancer cells and these key blood vessels are identified as high endothelial venules (HEV)...
  23. ncbi Identification of a major carbohydrate capping group of the L-selectin ligand on high endothelial venules in human lymph nodes as 6-sulfo sialyl Lewis X
    C Mitsuoka
    Program of Experimental Pathology, Japan
    J Biol Chem 273:11225-33. 1998
    ..species of sulfated sialyl Lewis X determinants, the putative L-selectin ligand, expressed on high endothelial venules (HEV) in human lymph nodes...
  24. ncbi Novel regulators of lymphocyte trafficking across high endothelial venules
    Eiji Umemoto
    Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Suita, Japan
    Crit Rev Immunol 31:147-69. 2011
    ..This constitutive lymphocyte trafficking is mediated by high endothelial venules (HEVs), which are present in secondary lymphoid tissues other than the spleen...
  25. ncbi HMG-CoA reductase inhibitor attenuates platelet adhesion in intestinal venules of hypercholesterolemic mice
    Anitaben Tailor
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3982, USA
    Am J Physiol Heart Circ Physiol 286:H1402-7. 2004
    ..with pravastatin (1 mg/kg) on hypercholesterolemia-induced platelet-endothelial (P/E) cell adhesion in intestinal venules. Mice were placed on either a normal diet (ND) or cholesterol-enriched diet (HCD) for 2 wk...
  26. ncbi Effects of L-NA and sodium nitroprusside on ischemia/reperfusion-induced leukocyte adhesion and macromolecular leakage in hamster cheek pouch venules
    C Simoes
    Laboratório de Pesquisas em Microcirculação, Universidade do Estado do Rio de Janeiro, Rua Sao Francisco Xavier 524, Rio de Janeiro, 20550 013, Brazil
    Microvasc Res 62:128-35. 2001
    ..is concluded that inhibition of nitric oxide formation by L-NA reduced both leukocyte adhesion in postcapillary venules and the increase in macromolecular leakage and that a NO donor such as SNP could enhance the macromolecular ..
  27. ncbi Inverse agonism of cannabinoid CB1 receptor blocks the adhesion of encephalitogenic T cells in inflamed brain venules by a protein kinase A-dependent mechanism
    Barbara Rossi
    Department of Pathology and Diagnostics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    J Neuroimmunol 233:97-105. 2011
    ..and prototype of the diarylpyrazoles series, induced a strong inhibition of firm adhesion in inflamed brain venules in intravital microscopy experiments...
  28. pmc Occlusion of cortical ascending venules causes blood flow decreases, reversals in flow direction, and vessel dilation in upstream capillaries
    John Nguyen
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
    J Cereb Blood Flow Metab 31:2243-54. 2011
    ..changes in blood flow and vessel diameter in capillaries after occlusion of single ascending or surface cortical venules as a function of the connectivity between the measured capillary and the occluded venule...
  29. ncbi Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism
    Rolando E Rumbaut
    Medical Care Line, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 290:H1671-9. 2006
    ..to determine whether endotoxin (lipopolysaccharide, LPS) modified platelet thrombus formation in mouse cremaster venules and whether Toll-like receptor 4 (TLR4) and neutrophils were involved in the response...
  30. pmc Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules
    J P Girard
    Laboratoire de Biologie Vasculaire, Institut de Pharmacologie et de Biologie Structurale du Centre National de la Recherche Scientifique, 205 route de Narbonne, 31077 Toulouse, France
    Proc Natl Acad Sci U S A 96:12772-7. 1999
    High endothelial venules (HEV) are specialized postcapillary venules found in lymphoid organs and chronically inflamed tissues that support high levels of lymphocyte extravasation from the blood...
  31. pmc Bone marrow-derived progenitor cells augment venous remodeling in a mouse dorsal skinfold chamber model
    Megan E Doyle
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 7:e32815. 2012
    ..Results show that different BMDC populations elicit different microvascular responses. In this model, Sca-1(+) progenitor cell-derived CXCL2 and IFNγ may mediate venule enlargement via modulation of the local inflammatory environment...
  32. ncbi A comparison of C3a and C5a-mediated stable adhesion of rolling eosinophils in postcapillary venules and transendothelial migration in vitro and in vivo
    R G DiScipio
    Laboratory of Immunology and Vascular Biology, La Jolla Institute for Experimental Medicine, CA 92037, USA
    J Immunol 162:1127-36. 1999
    ..with C3a resulted in a rapid and stable adhesion of rolling eosinophils, but not neutrophils, to postcapillary venules. However, C3a failed to evoke subsequent transmigration of the adherent eosinophils...
  33. pmc Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules
    Shan Liao
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:4577-82. 2007
    ..Thus, the Hec-6s-LacZ construct faithfully reproduces Hec-6st tissue-specific expression and can be used in further studies to drive expression of reporter or effector genes, which could visualize or inhibit HEV in autoimmunity...
  34. ncbi Enhanced adhesion of ligand-conjugated biodegradable particles to colitic venules
    Harshad S Sakhalkar
    Department of Chemical Engineering, Ohio University, Athens, Ohio 45701, USA
    FASEB J 19:792-4. 2005
    ..In post-capillary venules of the colon, significantly more alpha-V particles accumulate in colitic mice relative to (i) control mice (i.e...
  35. ncbi Estrogen replacement treatment in diabetic ovariectomized female rats potentiates postischemic leukocyte adhesion in cerebral venules
    Hao Liang Xu
    Neuroanesthesia Research Laboratory, University of Illinois at Chicago, Ill 60607, USA
    Stroke 35:1974-8. 2004
    ..We tested the hypothesis that in chronically hyperglycemic diabetic OVX females, chronic E2 replacement potentiates post-transient forebrain ischemia leukocyte adhesion...
  36. ncbi Sphingomyelinase and ceramide analogs induce vasoconstriction and leukocyte-endothelial interactions in cerebral venules in the intact rat brain: Insight into mechanisms and possible relation to brain injury and stroke
    Burton M Altura
    Departments of Physiology and Pharmacology, Health Science Center at Brooklyn, State University of New York, Brooklyn, NY 11203, USA
    Brain Res Bull 58:271-8. 2002
    ..or 1-0-acylceramide, resulted in potent, concentration-dependent constriction (and spasm) of cortical venules, followed by increased leukocyte rolling, decreased leukocyte velocities, increased leukocyte-endothelial wall ..
  37. ncbi Volume flow and wall shear stress quantification in the human conjunctival capillaries and post-capillary venules in vivo
    Aristotle G Koutsiaris
    Department of Medical Laboratories, School of Health Sciences, Technological Educational Institute of Larissa, Larissa, Greece
    Biorheology 44:375-86. 2007
    ..93) from a maximum of 9.55 N/m(2) at the smallest capillaries, down to a minimum of 0.28 N/m(2) at the higher diameter post capillary venules. The mean wall shear stress value for all microvessels was 1.54 N/m(2).
  38. pmc Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules
    Gengqian Zhang
    Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia 26506 9229, USA
    Am J Physiol Heart Circ Physiol 299:H1494-504. 2010
    ..Microvessel permeability was measured with hydraulic conductivity (L(p)) in individually perfused rat mesenteric venules. S1P-mediated changes in endothelial intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured in fura-2-..
  39. ncbi Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study
    M Kamran Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 45:2129-34. 2004
    ..Thus, associations between retinal arteriolar and venular diameters, and the AVR on the one hand and blood pressure, atherosclerosis, inflammation markers, and cholesterol levels on the other were examined in the Rotterdam Study...
  40. pmc Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes
    P R Streeter
    Department of Pathology, Stanford University School of Medicine, California 94305
    J Cell Biol 107:1853-62. 1988
    ..the blood by adhering to and migrating between those endothelial cells lining postcapillary high endothelial venules (HEV)...
  41. ncbi Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier
    Nickolai Sheikov
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 32:1399-409. 2006
    ..A small number of HRP-positive vesicles were observed in the venules. Focal delivery of HRP tracer was also observed in light microscopy...
  42. pmc The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment
    E S Baekkevold
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Exp Med 193:1105-12. 2001
    ..is defined by a multistep sequence of interactions between lymphocytes and endothelial cells in high endothelial venules (HEVs)...
  43. ncbi Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules
    Wolfgang H Cerwinka
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Am J Physiol Heart Circ Physiol 282:H1111-7. 2002
    ..NO) to endotoxin (lipopolysaccharide, LPS)-induced platelet-endothelial cell (P/E) adhesion in murine intestinal venules and 2) determine whether the antiadhesive action of NO is mediated by soluble guanylate cyclase (sGC)...
  44. pmc Near-wall micro-PIV reveals a hydrodynamically relevant endothelial surface layer in venules in vivo
    Michael L Smith
    Department of Biomedical Engineering, University of Virginia Health Science Center, Charlottesville, Virginia 22908, USA
    Biophys J 85:637-45. 2003
    ..near-wall fluorescent microparticle image velocimetry (micro-PIV) was used in mouse cremaster muscle venules in vivo to measure velocity profiles in the red cell-depleted plasma layer near the endothelial lining...
  45. ncbi Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice
    M Sperandio
    Department of Biomedical Engineering, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Blood 97:3812-9. 2001
    ..for synthesis of functional selectin ligands in vivo, leukocyte rolling flux and velocity were studied in venules of untreated and tumor necrosis factor-alpha (TNFalpha)-pretreated autoperfused cremaster muscles of C2GlcNAcT-I-..
  46. ncbi Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 N Walnut Street, 450 WARF, Madison, WI 53726, USA
    Arch Ophthalmol 124:87-94. 2006
    ..To examine the relationship of systemic markers of inflammation, endothelial dysfunction, and serum folate level to retinal vessel diameter...
  47. pmc Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules
    R E Young
    BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, U K
    Br J Pharmacol 137:1237-46. 2002
    ..through interleukin-1beta (IL-1beta)- and tumour necrosis factor-alpha (TNFalpha)-stimulated mouse cremasteric venules was investigated using established pharmacological interventions and the technique of intravital microscopy. 2...
  48. ncbi Leukocyte recruitment in hepatic injury: selectin-mediated leukocyte rolling is a prerequisite for CD18-dependent firm adhesion
    Daniel Klintman
    Department of Surgery, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    J Hepatol 36:53-9. 2002
    ..This study was designed to examine the role of selectins and CD18 in leukocyte recruitment in hepatic injury induced by tumor necrosis factor-alpha (TNF-alpha) and galactosamine (Gal) in vivo...
  49. ncbi Protective effects of leukopenia and tissue plasminogen activator in microvascular ischemia-reperfusion injury
    S Bertuglia
    Consiglio Nazionale delle Richerche Institute of Clinical Physiology, School of Medicine, University of Pisa, 56100 Pisa, Italy
    Am J Physiol Heart Circ Physiol 278:H755-61. 2000
    ..In conclusion, thrombus formation may be an additional and independent factor that with leukocyte-mediated mechanisms determines ischemia-reperfusion injury...
  50. ncbi Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography
    Satoshi Kashiwagi
    Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, Tokyo, Japan
    Circ Res 91:e55-64. 2002
    ..In venules, the magnitude of inhibitory responses elicited by the inhibitors was positively correlated with the density of ..
  51. ncbi Leukocyte phosphoinositide-3 kinase {gamma} is required for chemokine-induced, sustained adhesion under flow in vivo
    David F Smith
    Department of Molecular Physiology and Biophysics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Leukoc Biol 80:1491-9. 2006
    During inflammation, leukocytes roll along the wall of postcapillary venules scanning the surface for immobilized CXCL1, a chemokine that triggers firm adhesion by activating CXCR2 on the neutrophil...
  52. ncbi Inhibition of glycan shedding and leukocyte-endothelial adhesion in postcapillary venules by suppression of matrixmetalloprotease activity with doxycycline
    Aaron W Mulivor
    Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania, USA
    Microcirculation 16:657-66. 2009
    ..MMPs) in causing shedding of glycan components of the endothelial glycocalyx and delineate the efficacy of doxycycline as an inhibitor of white blood cell-endothelial cell (WBC-EC) adhesion and glycan shedding in postcapillary venules.
  53. ncbi Retinal microvascularisation abnormalities and cardiovascular risk
    Lea Mimoun
    INSERM U 698, Universite Paris VII, CHU Bichat, AP HP, 46, rue Henri Huchard, 75877 Paris Cedex 18, France
    Arch Cardiovasc Dis 102:449-56. 2009
    ..New techniques of retinal imaging, such as laser Doppler flowmetry, are still undergoing assessment and will help further to clarify these correlations...
  54. ncbi In vivo visualization of nitric oxide and interactions among platelets, leukocytes, and endothelium following hemorrhagic shock and reperfusion
    Mie Hiratsuka
    Department of Obstetrics and Gynecology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Inflamm Res 58:463-71. 2009
    ..We examined changes in nitric oxide (NO) distribution in the mesenteric microcirculation after hemorrhagic shock and reperfusion (H/R), and correlated NO production to leukocyte and platelet behavior...
  55. ncbi CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1
    Luca Battistini
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Santa Lucia, Rome, Italy
    Blood 101:4775-82. 2003
    ..with RRMS CD8+, but not with RRMS CD4+, T cells display increased rolling and arrest in inflamed murine brain venules. Moreover, CD8+, but not CD4+, lymphocytes from MS patients show increased rolling on P-selectin in vitro...
  56. ncbi Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins
    P Andre
    Center for Blood Research and the Department of Pathology, Harvard Medical School, Boston, MA, USA
    Blood 96:3322-8. 2000
    With the use of intravital microscopy, a new type of platelet-endothelial interaction in mouse mesenteric venules at low shear (80-100 seconds(-1)) is described...
  57. pmc PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane
    John Dangerfield
    Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Exp Med 196:1201-11. 2002
    ..001) neutrophil migration through interleukin (IL)-1beta-stimulated cremasteric venules, primarily at the level of the PBM, as analyzed by intravital and electron microscopy...
  58. ncbi Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase
    K Uchimura
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya 466, Japan
    J Biol Chem 273:22577-83. 1998
    ..In situ hybridization revealed that the mRNA was localized in high endothelial venules of mesenteric lymph nodes...
  59. ncbi CXCL13 is an arrest chemokine for B cells in high endothelial venules
    Naotoshi Kanemitsu
    Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine C8, 2 2, Yamada oka, Suita, 565 0871, Japan
    Blood 106:2613-8. 2005
    Chemokine receptor signaling is critical for lymphocyte trafficking across high endothelial venules (HEVs), but the exact mode of action of individual chemokines expressed in the HEVs is unclear...
  60. ncbi ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration
    Miao Tzu Huang
    Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Blood 107:4721-7. 2006
    ..Analysis of IL-1beta-induced leukocyte responses in cremasteric venules of KO animals by intravital microscopy indicated a defect in transmigration (44% inhibition) but not rolling or ..
  61. ncbi Aggregate formation of erythrocytes in postcapillary venules
    Sangho Kim
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H584-90. 2005
    ..The movements of erythrocytes in postcapillary venules of the rat spinotrapezius muscle at various flow rates were recorded with a high-speed video camera before and ..
  62. pmc Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo
    David Frommhold
    Children s Hospital, Neonatal Unit, University of Heidelberg, Germany
    BMC Immunol 8:31. 2007
    ..During inflammation, beta2-integrins mediate leukocyte adhesion to the endothelium accompanied by the activation of the spleen tyrosine kinase Syk...
  63. ncbi Chronic static magnetic field exposure alters microvessel enlargement resulting from surgical intervention
    Cassandra E Morris
    Dept of Biomedical Engineering, Univ of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Appl Physiol 103:629-36. 2007
    ....
  64. ncbi No detectable endothelial- or leukocyte-derived L-selectin ligand activity on the endothelium in inflamed cremaster muscle venules
    Einar E Eriksson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Leukoc Biol 84:93-103. 2008
    ..Here, I used intravital microscopy on mouse cremaster muscle venules to show that L-selectin influences leukocyte rolling in inflammation exclusively by mediating L-selectin/PSGL-1-..
  65. pmc Sequential contribution of L- and P-selectin to leukocyte rolling in vivo
    K Ley
    Department of Biomedical Engineering, University of Virginia Medical School, Charlottesville 22908
    J Exp Med 181:669-75. 1995
    ..We report here that approximately 13% of all leukocytes passing venules of the cremaster muscle of wild-type mice roll along the endothelium at < 20 min after surgical dissection...
  66. ncbi Exercise training prevents the inflammatory response to hypoxia in cremaster venules
    Teresa A Orth
    Dept of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Appl Physiol 98:2113-8. 2005
    ..Thus ET attenuated hypoxia-induced inflammation despite similar effects of hypoxia on tissue Po(2), venular shear rate, and circulating leukocyte count...
  67. ncbi PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction
    R H Adamson
    Departmentof Human Physiology, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 285:H406-17. 2003
    ..induced hyperpermeability is dependent on actin-myosin contractility by using individually perfused mesentery venules of pentobarbital-anesthetized rats...
  68. ncbi Microvascular thrombosis models in venules and arterioles in vivo
    Rolando E Rumbaut
    Medical Care Line, Michael E DeBakey V A Medical Center, Houston, Texas, USA
    Microcirculation 12:259-74. 2005
    ..in response to microvascular injury, platelet adhesion and subsequent thrombus formation may be observed in venules and arterioles in vivo...
  69. ncbi Are narrower or wider retinal venules associated with incident hypertension?
    Gerald Liew
    Hypertension 48:e10; author reply e11. 2006
  70. ncbi Plasma from conscious hypoxic rats stimulates leukocyte-endothelial interactions in normoxic cremaster venules
    Teresa Orth
    Univ of Kansas Medical Center, Kansas City, KS 66160, USA
    J Appl Physiol 99:290-7. 2005
    ..triggers hypoxia-induced inflammation, then plasma from hypoxic rats should elicit LEA in normoxic cremaster venules. Plasma from conscious donor rats breathing 10% O2-90% N2 for 5 min was applied topically to the cremaster of ..
  71. ncbi Preferential binding of leukocytes to the endothelial junction region in venules in situ
    Joel C Wojciechowski
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York, USA
    Microcirculation 12:349-59. 2005
    To determine whether leukocytes show a preference to firmly adhere to the endothelium near the endothelial cell (EC) junction in their native environment, i.e., blood-perfused venules in situ.
  72. ncbi Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules
    Fabienne Baffert
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H107-18. 2006
    ..injection of bradykinin resulted in leakage of fluorescent microspheres (diameter 25-1,000 nm) from tracheal venules. The leakage peaked in 3-4 min and resolved by 10 min...
  73. pmc The protein kinase MEK1/2 mediate vascular endothelial growth factor- and histamine-induced hyperpermeability in porcine coronary venules
    Mack H Wu
    Cardiovascular Research Institute, Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, 702 Southwest HK Dodgen Loop, Temple, TX 76504, USA
    J Physiol 563:95-104. 2005
    ..The apparent permeability coefficient of albumin was measured in isolated and perfused coronary venules. Application of VEGF induced a rapid increase in venular permeability, and the effect was blocked by PD98059 and ..
  74. ncbi Molecular determinants of the prothrombogenic phenotype assumed by inflamed colonic venules
    Mikiji Mori
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130 3932, USA
    Am J Physiol Gastrointest Liver Physiol 288:G920-6. 2005
    ..microscopy was used to monitor the trafficking of platelets and leukocytes and vascular permeability in colonic venules during the development of colonic inflammation induced by 3% dextran sodium sulfate (DSS)...
  75. ncbi Cutting edge: the B cell chemokine CXC chemokine ligand 13/B lymphocyte chemoattractant is expressed in the high endothelial venules of lymph nodes and Peyer's patches and affects B cell trafficking across high endothelial venules
    Yukihiko Ebisuno
    Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, Suita, Japan
    J Immunol 171:1642-6. 2003
    ..lymph nodes (LNs) and Peyer's patches (PPs), chemokines that regulate B cell trafficking across high endothelial venules (HEVs) remain to be fully elucidated...
  76. ncbi Mouse cremaster venules are predisposed to light/dye-induced thrombosis independent of wall shear rate, CD18, ICAM-1, or P-selectin
    Rolando E Rumbaut
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Microcirculation 11:239-47. 2004
    Microvascular adhesion of platelets to endothelium occurs in response to various inflammatory stimuli, and in venules is often accompanied by adherent leukocytes...
  77. ncbi Effect of fibrinogen on leukocyte margination and adhesion in postcapillary venules
    Mark J Pearson
    Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Microcirculation 11:295-306. 2004
    ..evaluate the role of fibrinogen (Fb) as a determinant of leukocyte (WBC) margination in postcapillary venules in light of its ability to induce red blood cell (RBC) aggregation with reductions in shear rate (gamma) and ..
  78. ncbi Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules
    Hiroyuki Yoneyama
    Department of Molecular Preventive Medicine and SORST, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Int Immunol 16:915-28. 2004
    ..Here we demonstrate that plasmacytoid DC (pDC) precursors can transmigrate across high endothelial venules (HEVs) of inflamed LNs in mice...
  79. pmc TNF-alpha activation of arterioles and venules alters distribution and levels of ICAM-1 and affects leukocyte-endothelial cell interactions
    Ronen Sumagin
    Dept of Pharmacology and Physiology, Univ of Rochester, Medical Center, Box 711, Rochester, NY 14642, USA
    Am J Physiol Heart Circ Physiol 291:H2116-25. 2006
    ..8 +/- 0.2-fold in arterioles and 1.7 +/- 0.2-fold in venules (P < 0.05). ICAM-1 expression on activated arteriolar ECs only reached the level of control venular ICAM-1...
  80. ncbi Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo
    Rebecca E Young
    Cardiovascular Medicine Unit, Eric Bywaters Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, Queen Mary University of London, London, United Kingdom
    J Immunol 172:4493-502. 2004
    ..In this study, NE(-/-) mice were used to investigate the role of NE in leukocyte migration through cremasteric venules, as observed by intravital microscopy, induced by locally administered cytokines IL-1beta and TNF-alpha and the ..
  81. ncbi Role of shear forces and adhesion molecule distribution on P-selectin-mediated leukocyte rolling in postcapillary venules
    Michael B Kim
    Dept of Biological Engineering, Univ of Rochester, Box 711, Medical Center, Rochester, NY 14642, USA
    Am J Physiol Heart Circ Physiol 287:H2705-11. 2004
    ..However, neither the spatial pattern of P-selectin expression in postcapillary venules nor the effect of local expression patterns on rolling behavior in intact functional venules is known...
  82. pmc C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment
    Tracy Stokol
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 200:835-46. 2004
    ..We show that after intravenous injection, preformed soluble ICs are rapidly deposited in the postcapillary venules of the cremaster microcirculation, secondary to increased vascular permeability...
  83. pmc CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo
    Michael L Smith
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 200:935-9. 2004
    The signaling events leading to the activation of integrins and firm arrest of rolling neutrophils in inflamed venules have yet to be elucidated...
  84. ncbi Activation of mast cells by systemic hypoxia, but not by local hypoxia, mediates increased leukocyte-endothelial adherence in cremaster venules
    Randy Dix
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Appl Physiol 95:2495-502. 2003
    ..hypoxia/systemic normoxia), however, does not elicit increased leukocyte-endothelial adherence (LEA) in cremaster venules. This could be due to a short time of leukocyte exposure to the hypoxic cremaster environment...
  85. ncbi Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules
    Wolfgang H Cerwinka
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Am J Physiol Heart Circ Physiol 284:H535-41. 2003
    ..the contribution of superoxide to LPS-induced platelet-endothelial cell (P/E) adhesion in murine intestinal venules. The adhesion of rhodamine-6G-labeled murine platelets was monitored by intravital fluorescence microscopy...
  86. ncbi Leukocyte arrest during cytokine-dependent inflammation in vivo
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 164:3301-8. 2000
    Leukocyte rolling along the walls of inflamed venules precedes their adhesion during inflammation. Rolling leukocytes are thought to arrest by engaging beta2 integrins following cellular activation...
  87. ncbi Tortuosity of arterioles and venules in quantifying plus disease
    Suzanne C Johnston
    Duke University Eye Center, Durham, North Carolina 27710, USA
    J AAPOS 13:181-5. 2009
    ..Our objectives were to determine (1) whether examiners could accurately discriminate between arterioles and venules and (2) whether tortuosity sufficient for plus disease and pre-plus disease was assessed most accurately by ..
  88. ncbi Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels
    W Weninger
    The Center for Blood Research and Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 12:665-76. 2000
    Noninflamed skin venules support constitutive leukocyte rolling. P-selectin controls the rolling frequency, whereas E-selectin dictates rolling velocity (Vroll)...
  89. ncbi CD4+ T cells of both the naive and the memory phenotype enter rat lymph nodes and Peyer's patches via high endothelial venules: within the tissue their migratory behavior differs
    J Westermann
    Center of Anatomy, Medical School of Hannover, Germany
    Eur J Immunol 27:3174-81. 1997
    ..cells predominantly enter lymphoid organs such as lymph nodes (LN) and Peyer's patches (PP) via high endothelial venules (HEV), whereas memory T cells migrate mainly into non-lymphoid organs...
  90. ncbi Distribution of oxygen tension on the surface of arterioles, capillaries and venules of brain cortex and in tissue in normoxia: an experimental study on rats
    E Vovenko
    Pavlov Institute of Physiology of Russian Academy of Sciences, Nab Makarova, Bld 6, Saint Petersburg, 199034, Russia
    Pflugers Arch 437:617-23. 1999
    The distribution of oxygen tension (PO2) was studied in normoxia on the surface of arterioles, capillaries and venules of rat brain cortex, both longitudinally and in tissue radially from the wall of microvessels...
  91. ncbi Key role of platelet procoagulant activity in tissue factor-and collagen-dependent thrombus formation in arterioles and venules in vivo differential sensitivity to thrombin inhibition
    Marijke J E Kuijpers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Microcirculation 15:269-82. 2008
    ..We investigated the interplay of these processes in vivo in a mouse model of arteriolar and venular thrombus formation...
  92. ncbi Differential effect of E-selectin antibodies on neutrophil rolling and recruitment to inflammatory sites
    C L Ramos
    Department of Biomedical Engineering, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Blood 89:3009-18. 1997
    ..Neither 9A9 nor 10E9.6 alone blocked leukocyte rolling in tumor necrosis factor-alpha-treated venules of Balb/c mice, but 9A9 almost completely inhibited leukocyte rolling when combined with the function-blocking ..
  93. ncbi Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
    M Cella
    Basel Institute for Immunology
    Nat Med 5:919-23. 1999
    ..These cells are found in inflamed lymph nodes in and around the high endothelial venules. They express CD62L and CXCR3, and produce extremely large amounts of type I interferon after stimulation with ..
  94. pmc Thromboxane A(2) contributes to the mediation of flow-induced responses of skeletal muscle venules: role of cyclooxygenases 1 and 2
    A Racz
    Department of Pathophysiology, Semmelweis University, Budapest, Hungary
    J Vasc Res 46:397-405. 2009
    It has been shown that increases in intraluminal flow elicit dilation in venules, but the mediation of response is not yet clarified...
  95. ncbi Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules
    J P Girard
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 271:4511-7. 1996
    High endothelial venules (HEV) are specialized plump postcapillary venules in lymphoid tissues that support high levels of lymphocyte extravasation from the blood...
  96. ncbi Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin
    S Yamada
    Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114, USA
    Blood 86:3487-92. 1995
    ..Rolling in the postcapillary venules in SC tissue of P-selectin-deficient mice was significantly lower than that in wild-type mice under the basal ..
  97. ncbi Effect of aggregation and shear rate on the dispersion of red blood cells flowing in venules
    Jeffrey J Bishop
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
    Am J Physiol Heart Circ Physiol 283:H1985-96. 2002
    ..The shear-induced random movements observed in this study may increase the radial transport of particles and solutes within the bloodstream by orders of magnitude...
  98. ncbi Morphologic assessment of leukocyte-endothelial cell interactions in mesenteric venules subjected to ischemia and reperfusion
    M G Oliver
    Department of Cellular Biology, Louisiana State University Medical Center, Shreveport
    Inflammation 15:331-46. 1991
    ..of the mesenteric microcirculation have demonstrated that leukocyte adherence and emigration in postcapillary venules are a characteristic feature of tissues exposed to ischemia-reperfusion...
  99. ncbi CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules
    Satoshi Ueha
    Department of Molecular Preventive Medicine and SORST, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    J Leukoc Biol 82:1230-8. 2007
    ..nTreg in such CCR7-deficient mice was also observed, but this occurred mainly in the medullary high endothelial venules. Taken together, these data provide the evidence that CCR7 mediates nTreg migration to the paracortical areas of ..
  100. ncbi Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane
    R D Thompson
    BHF Cardiovascular Medicine Unit, Imperial College School of Medicine at the National Heart and Lung Institute, Hammersmith Hospital, London, United Kingdom
    Blood 97:1854-60. 2001
    ..responses in interleukin 1beta (IL-1beta)- and tumor necrosis factor-alpha (TNFalpha)-activated cremasteric venules of PECAM-1-deficient mice using intravital and electron microscopy...
  101. ncbi Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals
    Dian Feng
    Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Microsc Res Tech 57:289-326. 2002
    ....

Research Grants65

  1. Regulation of vasculature by estrogen receptors during aging in mouse models
    Margaret Markiewicz; Fiscal Year: 2013
    ..provided by applicant): Angiogenesis is a process of new vessel formation from pre existing capillaries or venules. It has been reported that this process is impaired in aged tissues...
  2. Tumor Cell Arrest and Adhesion in the Microcirculation
    Bingmei M Fu; Fiscal Year: 2013
    ..to arrest at the locations of higher shear rates/stresses and shear rate/stress gradients in the post-capillary venules of microvasculature...
  3. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven D Rosen; Fiscal Year: 2010
    ..Homing is initiated by the rolling of lymphocytes on high endothelial venules (HEVs) within the lymph node...
  4. Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In Vivo
    Paul S Frenette; Fiscal Year: 2013
    ..imaging in a humanized mouse model of sickle cell disease (SCD) that adherent leukocytes recruited in inflamed venules, played a direct role in VOC by interacting with circulating erythrocytes (RBC)...
  5. The Regulation of Inflammatory Responses by CD73
    Linda F Thompson; Fiscal Year: 2012
    ..Cd73-/- mice also show increased lymphocyte migration across high endothelial venules (HEV) of draining lymph nodes. This is also due to lack of A2BAR signaling in non-hematopoietic cells...
  6. MELANOMA VACCINES USING MHC-ASSOCIATED PEPTIDES
    CRAIG LEE SLINGLUFF; Fiscal Year: 2012
    ..T cells, B cells, and peripheral node addressin (PNAd) expressing microvessels suggestive of high endothelial venules. Preliminary studies in sites of repeated peptide vaccination with adjuvant show other features of lymphoid ..
  7. Lymphotoxin: Regulation and Biologic Function
    NANCY RUDDLE; Fiscal Year: 2009
    ..contribute importantly to inflammation and lymphoid organ development, including regulation of high endothelial venules (HEVs) in lymph nodes (LNs). In the next years, regulation of lymphatic vessels (LVs) will be studied...
  8. Intratumoral genetic therapy for lung cancer
    Steven M Dubinett; Fiscal Year: 2013
    ..CCL21 is a lymphoid chemokine that is predominantly and constitutively expressed by high endothelial venules in lymph nodes and Peyer's patches and by lymphatic vessels, stromal cells in the spleen and appendix...
  9. CRCNS:US French Coll:Computational Imaging of the Aging Cerebral Microvasculature
    Bradley P Sutton; Fiscal Year: 2013
    ..tissue occurs in the micro-vascular vessels, extending from the arterioles through the capillaries and into the venules. Cortical micro-vascular networks can be described by topological characteristics, such as: vascular density, ..
  10. CB2 Receptor Regulatin of Inflammatory Response in EAE
    Ronald F Tuma; Fiscal Year: 2012
    ..the effects of O-1966 on encephalitogenic Teffector and Treg cell rolling and adhesion to CNS postcapillary venules by intravital microscopy, its effect on the expression of adhesion molecules in Teff/Treg cells and in CNS ..
  11. Mechanisms of rapid paravascular fluid transport in the brain
    Jeffrey J Iliff; Fiscal Year: 2012
    ..paravascular transport follows penetrating arterioles while outward clearance of extracellular fluid follows venules. In Specific Aim 2 I will test whether this directional transport is driven mechanically by arterial pulsation...
  12. Impact of Alcohol on Hemorrhagic Shock-Induced Microvascular Dysfunction
    Jerome W Breslin; Fiscal Year: 2012
    ..increased capillary pressure and plasma filtration, and by increasing paracellular permeability of postcapillary venules, facilitating enhanced extravasation of fluids and solutes, causing edema...
  13. TNF family members for lymph angiogenesis and lymph node hypertrophy
    Yang Xin Fu; Fiscal Year: 2013
    Rapid development of lymphatic vessels (LV) and high endothelial venules (HEV) in peripheral tissues leads to hypertrophy of draining lymph nodes (LN) during inflammation/vaccination, but the molecular mechanism regulating LN ..
  14. Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara
    J Marc Simard; Fiscal Year: 2013
    ..subunits of the NC(Ca-ATP) channel, SUR1 and TRPM4, are prominently up-regulated in neurons, capillaries and venules in cortical regions with overlying SAH;(ii) cortical regions that show up-regulation of SUR1 and TRPM4 also show ..
  15. Biomechanics of Leukocytes and Molecular Imaging Agents
    MICHAEL BRANDEAU LAWRENCE; Fiscal Year: 2010
    ..the cellular biomechanics of leukocytes as they become adherent in flow chamber systems and in postcapillary venules in vivo...
  16. Multiscale, Transport-Dependent NO Signaling: Cells to Vascular Networks
    Dov Jaron; Fiscal Year: 2013
    ..and NO, combined with vessel diameter measurements, will be obtained from individual small arteries, arterioles, venules, and small veins under normal and abnormal physiological conditions to characterize relationships among vascular ..
  17. Caveolar Transport of Therapeutic Nanoparticles
    Zhenjia Wang; Fiscal Year: 2013
    ..microscopy we will determine the role of caveolae in mediating nanoparticle transport in cremaster muscle venules of wild type and caveolin-1 knockout mice, shown to lack caveolae...
  18. MORPHINE ACTIONS ON THE IMMUNE SYSTEM
    Sulie L Chang; Fiscal Year: 2012
    ..potentiates IL- 1[3-induced immune responses, such as leukocyte-endothelial adhesion (LEA), in mesenteric venules. Thus, it appears that chronic morphine exposure can promote a potentially damaging inflammatory reaction by ..
  19. Novel Mechanisms of Chronic Inflammation in Sjogren's Syndrome
    GARY ANDREW WEISMAN; Fiscal Year: 2010
    ..marked expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in venules surrounded by infiltrating CD4+ T cells...
  20. Imaging the Mitochondrial Response to Neural Activity
    Roger J Springett; Fiscal Year: 2010
    ..and test the hypothesis that changes in the tissue hematocrit are insensitive to changes in the draining venules and so provide more localized vascular images of activation (iv) Develop techniques to image the cortex on the ..
  21. Beyond PECAM: Mechanisms of Transendothelial Migration
    William A Muller; Fiscal Year: 2013
    ..diapedesis-the step in this process in which leukocytes pass across the endothelial cells lining postcapillary venules at sites of leukocyte egress...
  22. Role of adipocytes in local and systemic inflammation
    Chantal A Rivera; Fiscal Year: 2010
    ..to assess the influence of diet and weight gain/fat deposition on leukocyte trafficking in postcapillary venules that drain adipose tissue. 2...
  23. Novel Strategies to Antagonize Cocaine-Enhanced HIV Pathobiology
    THORSTEN ROMAN MEMPEL; Fiscal Year: 2013
    ..Similar HIV effects may occur in high endothelial venules (HEVs), the "gatekeepers" for immune cell trafficking in lymph nodes...
  24. Development of a BBB Model to Study Transendothelial Cell Migration
    Damir Janigro; Fiscal Year: 2011
    ..for studying leukocyte extravasation in the brain, which is likely to occur at the post-capillary segment (venules)...
  25. Migration and Trafficking in Tolerance 10/07
    Jonathan S Bromberg; Fiscal Year: 2012
    ..DC (pDC) in the T cell areas of the lymph node (LN) near the abluminal surface of the high endothelial venules (HEV)...
  26. COAGULATION ACTIVATION IN SICKLE CELL DISEASE
    Kenneth I Ataga; Fiscal Year: 2010
    ..Furthermore, because the acute pain episode appears to result from the occlusion of postcapillary venules by the interaction of red blood cells and other cellular elements with the vascular endothelium and ..
  27. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2009
    ..LPS) and pyrogenic cytokines activate production of prostaglandin E2 (PGE2) by endothelial cells lining small venules at the margins of the brain. PGE2 acts upon specific EP receptors in the preoptic area to cause fever responses...
  28. Development of a BBB Model to Study Transendothelial Cell Migration
    Damir Janigro; Fiscal Year: 2013
    ..we propose the following Phase II Specific Aims: To optimize the performance of a dynamic in vitro capillary-venules model of the brain cerebrovasculature permissive for leukocyte extravasation...
  29. INFLAMMATORY MECHANISMS IN LUNG VASCULAR SEGMENTS
    Kaushik Parthasarathi; Fiscal Year: 2012
    ..Our planned studies will provide a greater understanding of the intercellular communication in lung arterioles, capillaries and venules, and thus lead to development of new therapies for treatment of ALI.
  30. Lymphoid Structure in Tolerance
    Jonathan S Bromberg; Fiscal Year: 2010
    ..DC (pDC) in the T cell areas of the lymph node (LN) near the abluminal surface of the high endothelial venules (HEV)...
  31. Role of chemokines in astro-neuronal activation in cerebral malaria
    Monique Stins; Fiscal Year: 2009
    ..falciparum infected red blood cells (Pf- IRBC) in brain venules. However, the molecular interactions of Pf-IRBC with the blood brain barrier (BBB) endothelial interface and the ..
  32. Microscale Oxygenation Mapping During Stroke
    Andrew K Dunn; Fiscal Year: 2013
    ..the longitudinal oxygen gradients from surface and penetrating arterioles through capillaries and draining venules under baseline conditions and after occlusion of a single arteriole...
  33. Notch mediated arterial-venous specification in the mammalian cerebrovasculature
    Corinne Nielsen; Fiscal Year: 2013
    ..Post-capillary venules join successively wider veins to return blood to the heart...
  34. Platelets and Their Microparticles in the Inflamed Microcirculation
    CLIFTON WAYNE SMITH; Fiscal Year: 2013
    ..are necessary for efficient inflammatory responses, via their extravasation across inflamed post-capillary venules and release of microparticles...
  35. HTS assay development for inhibitors of sickle cell
    PAUL FRENETTE; Fiscal Year: 2006
    ..The selectin family of adhesion molecules plays key role in the rolling and adhesion of leukocytes in systemic venules. Previous studies have shown that sickle erythrocytes can interact with P-selectin expressed on activated ..
  36. CELL ADHESION AND CARBOHYDRATE LIGANDS
    ROGER LAINE; Fiscal Year: 1993
    ..fucose-sulfates (fucoidin), polyphosphomannans, and inhibited binding of lymphocytes to high endothelial venules. This suggested a carbohydrate involvement in the interaction...
  37. XENOGENEIC MODEL FOR HOMING OF HUMAN LYMPHOCYTES
    Sharon Evans; Fiscal Year: 1993
    ..of the L-selectin homing receptor on lymphocytes with the vascular addressin on post-capillary high endothelial venules (HEV)...
  38. Multiscale Computational Modeling of Platelet Deposition and Coagulation in Flow
    Aaron L Fogelson; Fiscal Year: 2012
    ..blood vessels (arterioles), and ii) combined platelet thrombosis and coagulation in small vessels (arterioles and venules) will be developed...
  39. The role of chemokines in experimental thyroiditis
    Sergio A Lira; Fiscal Year: 2012
    ..organize in structures resembling lymphoid follicles, in which vascular structures such as high endothelial venules (HEV) and lymphatics are present...
  40. PRECONDITIONING: PMN ADHESION AND MICROVASCULAR INJURY
    RONALD KORTHUIS; Fiscal Year: 2003
    ..attenuates oxidant production, P-selectin expression, leukocyte adhesion to and emigration across postcapillary venules, microvascular barrier disruption, capillary no-reflow, and myocyte necrosis in skeletal muscles subsequently ..
  41. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2009
    ..The initial event is the rolling of the lymphocyte on high endothelial venules (HEVs) within the lymph node. This is followed by arrest and transmigration of lymphocytes into the lymph node...
  42. Role of Vascular Heterogeneity in Thrombosis
    Barbara Furie; Fiscal Year: 2006
    ..Here we propose to explore differences in thrombus formation in additional vascular beds including venules of the cremaster muscle and the arterioles and venules of the pia mater with its unique endothelial cell ..
  43. BRONCHIAL CIRCULATION AND LUNG FLUID BALANCE
    George Kramer; Fiscal Year: 1993
    ..bradykinin, and substance P, alter the ultrastructure and selectively increase the permeability of bronchial venules while having relatively little effect on the pulmonary circulation...
  44. RECEPTOR TOPOGRAPHY IN MICROVASCULAR LEUKOCYTE ADHESION
    Ulrich von Andrian; Fiscal Year: 2005
    ..It is critical for this process that lymphocytes enter PLN via high endothelial venules (REV) in the nodal paracortex...
  45. Microvascular O2 Delivery: Impact of Erythrocyte-Released ATP
    Mary Ellsworth; Fiscal Year: 2009
    ..In the microcirculation, ATP released from RBCs in response to reduced O2 tension in capillaries or venules can function in a paracrine fashion to produce vasodilation locally as well as vasodilation that is conducted to ..
  46. Physiological Basis of Vascular Contractility
    David Zawieja; Fiscal Year: 2006
    ..In response to pressure elevation, arterioles exhibit strong, sustained constrictions; venules transient, weak constrictions; lymphatics increase their rate of phasic contractions, with little or no change in ..
  47. A4B7 INTEGRIN IN INTESTINAL INFLAMMATION AND IMMUNITY
    Eugene Butcher; Fiscal Year: 1999
    ..alpha4Beta7 in lymphocyte attachment, rolling and activation-dependent arrest in Peyer's patch-high endothelial venules (HEV); and in the venules of the small intestinal lamina propria...
  48. Blood rheology, cell adhesion and endothelial activation
    Lance Munn; Fiscal Year: 2007
    ..time, estimated the hydrodynamic forces exerted in flowing blood that influence cells as they enter postcapillary venules and roll on the endothelium...
  49. LYMPHOCYTE HOMING RECEPTORS AND METASTASIS
    Mark Siegelman; Fiscal Year: 2001
    ..normal lymphocytes from bloodstream into peripheral lymphoid organs was identified as specialized postcapillary venules and named high endothelial venules (HEVs)...
  50. REGULATION OF MICROCIRCULATORY MUSCLE-SKIN HEAT TRANSFER
    Sheldon Weinbaum; Fiscal Year: 1992
    ..used to examine the thermal threshold and sensitivity, and the underlying physiology of branching arterioles and venules of the microvascular network subjected to both heating and cooling; (iii) pharmacological techniques will be used ..
  51. BASIS FOR ALCOHOL AND COCAINE STROKES--ROLE OF MG2+
    Burton Altura; Fiscal Year: 2004
    ..The result is a sustained, localized inflammatory response characterized by leukocyte rolling-adhesion on venules, intense microvascular ischemia or venular rupture leading to focal hemorrhages...
  52. CRL POLYMORPHISMS AND SESCEPTIBILITY TO SEVERE MALARIA
    JOANN MOULDS; Fiscal Year: 2000
    ..been suggested that severity of disease may relate to the ability of infected erythrocytes to sequester in the venules of various organs...
  53. STUDIES ON THE IMMUNOPATHOLOGY OF MULTIPLE SCLEROSIS
    UTE TRAUGOTT; Fiscal Year: 1990
    ..For this, receptors for high endothelial venules (HEV) and presence of various adhesion molecules such as leukocyte function associated antigens (LFA-1, LFA-2, ..
  54. PATHWAY(S) OF LEUKOCYTE EXTRAVASATION IN INFLAMMATION
    Ann Dvorak; Fiscal Year: 2001
    ..events in inflammation is the emigration of leukocytes from the blood into the tissues by way of postcapillary venules. This process, the subject of intense investigation for more than a century, has been resolved into successive ..
  55. LEUKOCYTE RECEPTORS FOR ENDOTHELIUM
    Eugene Butcher; Fiscal Year: 1993
    ..3) The cellular and molecular mechanisms responsible for leukocyte-specific interactions with postcapillary venules (PCV) during extravasation into inflammatory sites will be explored...
  56. MECHANICAL CORRELATES OF NEUTROPHIL ACTIVATION
    ROBERT HOCHMUTH; Fiscal Year: 2000
    ..Second, it must recognize sites of inflammation in the post-capillary venules and rapidly attach to these sites by rolling and then firmly adhering to the endothelial cells that line the ..
  57. NOVEL MONOCYTE AND T CELL TRAFFICKING RECEPTOR
    Eugene Butcher; Fiscal Year: 1999
    ..L11 is defined by a monoclonal antibody (MAb) that blocks monocytoid cell binding to inflamed high endothelial venules (HEV)...
  58. ENDOTHELIAL-BINDING LECTINS OF LYMPHOID MALIGNANCIES
    Lloyd Stoolman; Fiscal Year: 1991
    This project focuses on the adhesive interaction between human lymphoid cells and the high endothelial venules of peripheral lymph nodes (PNHEV) which initiates the migration of circulating cells into tissue...
  59. REGULATION OF LEUKOCYTE RECIRCULATION
    Thomas Tedder; Fiscal Year: 2001
    ..L-selectin plays a critical role in lymphocyte migration by mediating binding to the high endothelial venules of peripheral lymph nodes, and mediates leukocyte rolling along the vascular wall at sites of inflammation...
  60. HIGH RESOLUTION BLOOD FLOW MAPPING IN OCULAR TISSUES
    Katherine Ferrara; Fiscal Year: 2001
    ..existing techniques, and provides the first non-invasive opportunity to evaluate blood flow in arterioles and venules in opaque tissues...
  61. HIGH RESOLUTION BLOOD FLOW MAPPING IN OCULAR TISSUES
    Katherine Ferrara; Fiscal Year: 2003
    ..existing techniques, and provides the first non-invasive opportunity to evaluate blood flow in arterioles and venules in opaque tissues...
  62. MOLECULAR BIOLOGY OF HUMAN LEUKOCYTE HOMING RECEPTOR
    Eugene Butcher; Fiscal Year: 1993
    The interaction of lymphocytes with high endothelial venules (HEV) is of central importance in regulating lymphocyte traffic in vivo, and has also proven to be an excellent model for the study of heterotypic cell-cell recognition ..
  63. Hydrodynamic Contributions to Neutrophil Adhesion in Branched Vessels
    Kathleen Lamkin Kennard; Fiscal Year: 2007
    ..mechanistic interactions between neutrophil adhesion and local hydrodynamic forces in converging post-capillary venules and venular networks...
  64. CYTOKINE EFFECTS ON ENDOTHELIUM IN CHRONIC INFLAMMATION
    Druie Cavender; Fiscal Year: 1991
    ..the blood into either lymphoid organs or chronic inflammatory sites occurs primarily through unique postcapillary venules (PCV) referred to as high endothelial venules (HEV) because of their content of prominent cuboidal endothelial ..