capillaries

Summary

Summary: The minute vessels that connect the arterioles and venules.

Top Publications

  1. pmc The effect of matrix density on the regulation of 3-D capillary morphogenesis
    Cyrus M Ghajar
    Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697, USA
    Biophys J 94:1930-41. 2008
  2. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
  3. pmc Bidirectional control of CNS capillary diameter by pericytes
    Claire M Peppiatt
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 443:700-4. 2006
  4. ncbi Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia
    Jason A Vincent
    Case Western Reserve University, Department of Medicine, Division of Clinical and Molecular Endocrinology, Center for Diabetes Research, Cleveland, OH 44106, USA
    Diabetes 56:224-30. 2007
  5. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
  6. pmc Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy
    Timothy S Kern
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 5029, USA
    Exp Diabetes Res 2007:95103. 2007
  7. ncbi Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo
    D Donovan
    Tumour Targeting Group, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
    Angiogenesis 4:113-21. 2001
  8. ncbi VEGF is required for growth and survival in neonatal mice
    H P Gerber
    Departments of Cardiovascular Research and Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Development 126:1149-59. 1999
  9. pmc Deletion of the laminin alpha4 chain leads to impaired microvessel maturation
    Jill Thyboll
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17 177 Stockholm, Sweden
    Mol Cell Biol 22:1194-202. 2002
  10. ncbi Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling
    S E Bell
    Department of Pathology and Laboratory Medicine, Texas A and M University System Health Science Center, College Station 77843 1114, USA
    J Cell Sci 114:2755-73. 2001

Detail Information

Publications265 found, 100 shown here

  1. pmc The effect of matrix density on the regulation of 3-D capillary morphogenesis
    Cyrus M Ghajar
    Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697, USA
    Biophys J 94:1930-41. 2008
    ..Although roles for matrix stiffness and ligand binding density have previously been identified, our results emphasize the importance of diffusion restrictions in limiting capillary morphogenesis...
  2. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
    ..Endothelial cells of the sprouting capillaries in the mutant mice appeared to be unable to attract PDGF-Rbeta-positive pericyte progenitor cells...
  3. pmc Bidirectional control of CNS capillary diameter by pericytes
    Claire M Peppiatt
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 443:700-4. 2006
    ..Blood flow is assumed to be regulated by precapillary arterioles, because capillaries lack smooth muscle...
  4. ncbi Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia
    Jason A Vincent
    Case Western Reserve University, Department of Medicine, Division of Clinical and Molecular Endocrinology, Center for Diabetes Research, Cleveland, OH 44106, USA
    Diabetes 56:224-30. 2007
    ..the role of IL-1beta and caspase-1 (the enzyme that produces it) in diabetes-induced degeneration of retinal capillaries. Caspase-1 activity is increased in retinas of diabetic and galactosemic mice and diabetic patients...
  5. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
    ....
  6. pmc Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy
    Timothy S Kern
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 5029, USA
    Exp Diabetes Res 2007:95103. 2007
    ..of at least the early stages of diabetic retinopathy, especially occlusion and degeneration of retinal capillaries. A common feature of a number of these therapies is that they inhibit production of inflammatory mediators...
  7. ncbi Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo
    D Donovan
    Tumour Targeting Group, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
    Angiogenesis 4:113-21. 2001
    ..morphological features of tubules formed in the Matrigel assay and this new 'Co-culture' assay, with those of capillaries formed in a microvascular bed in vivo...
  8. ncbi VEGF is required for growth and survival in neonatal mice
    H P Gerber
    Departments of Cardiovascular Research and Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Development 126:1149-59. 1999
    ..Thus, VEGF is essential for growth and survival in early postnatal life. However, in the fully developed animal, VEGF is likely to be involved primarily in active angiogenesis processes such as corpus luteum development...
  9. pmc Deletion of the laminin alpha4 chain leads to impaired microvessel maturation
    Jill Thyboll
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17 177 Stockholm, Sweden
    Mol Cell Biol 22:1194-202. 2002
    ..The results demonstrate a central role for the laminin alpha4 chain in microvessel growth and, in the absence of other laminin alpha chains, in the composition of endothelial basement membranes...
  10. ncbi Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling
    S E Bell
    Department of Pathology and Laboratory Medicine, Texas A and M University System Health Science Center, College Station 77843 1114, USA
    J Cell Sci 114:2755-73. 2001
    ..These data further elucidate the genetic events regulating capillary tube formation in a 3D matrix environment...
  11. pmc GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 12:42-52. 2010
    ..LPL is synthesized and secreted by myocytes and adipocytes, but then finds its way into the lumen of capillaries, where it hydrolyzes lipoprotein triglycerides...
  12. ncbi Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes
    Ling Zheng
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Invest Ophthalmol Vis Sci 48:361-7. 2007
    ..The response of the retinal vasculature to an injury (ischemia and reperfusion; I/R) that is known to cause neuronal degeneration was studied...
  13. ncbi Ultrastructural damage of capillaries in the neocortex in schizophrenia
    Natalya A Uranova
    Laboratory of Clinical Neuropathology, Mental Health Research Center, Russian Academy of Medical Sciences, Zagorodnoe shosse 2, Moscow, Russia
    World J Biol Psychiatry 11:567-78. 2010
    ..The aim of the study was to clear up whether there are abnormalities in the microvasculature in the neocortex in schizophrenia...
  14. ncbi Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes
    Rachel A Feit-Leichman
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:4281-7. 2005
    ..The objective of this study was to characterize the occurrence and pathologic progression of diabetic retinopathy in C57Bl/6J mice...
  15. ncbi Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    M S O'Reilly
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 88:277-85. 1997
    ..Together with angiostatin data, these findings validate a strategy for identifying endogenous angiogenesis inhibitors, suggest a theme of fragments of proteins as angiogenesis inhibitors, and demonstrate dormancy therapy...
  16. ncbi The microvascular system of the striate and extrastriate visual cortex of the macaque
    Bruno Weber
    Max Planck Institut für biologische Kybernetik, Spemannstr 38, 72076 Tubingen, Germany
    Cereb Cortex 18:2318-30. 2008
    ....
  17. ncbi Fibronectin, laminin, vitronectin and their receptors at newly-formed capillaries in proliferative diabetic retinopathy
    R P Casaroli Marano
    Department of Biochemistry and Physiology, University of Barcelona, Spain
    Exp Eye Res 60:5-17. 1995
    ..pattern of fibronectin (FN), laminin (LN), vitronectin (VN) and their receptors in the newly-formed capillaries of PDR...
  18. pmc Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance
    Michael Spencer
    Department of Medicine, Division of Endocrinology, and the Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Clin Endocrinol Metab 96:E1990-8. 2011
    ..Insulin resistance is associated with inflammation, fibrosis, and hypoxia in adipose tissue...
  19. ncbi Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function
    D P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 281:F887-99. 2001
    ..We hypothesize that severe ischemic injury results in a permanent alteration of renal capillary density, contributing to a urinary concentrating defect and the predisposition toward the development of renal fibrosis...
  20. ncbi Complement C4d in graft capillaries -- the missing link in the recognition of humoral alloreactivity
    Helmut E Feucht
    Department of Organ Transplantation Nephrology, Fachklinik Bad Heilbrunn, Woernerweg 30, D 83670 Bad Heilbrunn, Germany
    Am J Transplant 3:646-52. 2003
    Staining of C4d in graft capillaries has emerged as a useful method to detect antibody-mediated rejections in situ...
  21. ncbi Patterning human stem cells and endothelial cells with laser printing for cardiac regeneration
    Ralf Gaebel
    Reference and Translation Center for Cardiac Stem Cell Therapy, Department of Cardiac Surgery, University of Rostock, 18057 Rostock, Germany
    Biomaterials 32:9218-30. 2011
    ..LIFT-based Tissue Engineering of cardiac patches for the treatment of myocardial infarction might improve wound healing and functional preservation...
  22. ncbi Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture
    Gabriella Schiera
    Dipartimento di Biologia Cellulare e dello Sviluppo Alberto Monroy, Palermo, Italy
    J Cell Mol Med 7:165-70. 2003
    ..In particular, we found that, in the presence of astrocytes, the neuron-induced synthesis and localization of occludin is precocious as compared to cells cocultured with neurons only...
  23. ncbi Comparison of capillary architecture between slow and fast muscles in rats using a confocal laser scanning microscope
    Shinichiro Murakami
    Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 64:11-8. 2010
    ..The capillary density and capillary-to-fiber ratio were significantly higher, and the course of the capillaries was more tortuous, in the soleus muscle than in the EDL muscle...
  24. ncbi Pericytes and the pathogenesis of diabetic retinopathy
    Hans Peter Hammes
    Fifth Medical Clinic, Medical Faculty of the University of Heidelberg, Mannheim, Germany
    Diabetes 51:3107-12. 2002
    ..Pericyte loss, microaneurysms, and acellular capillaries are characteristic for the diabetic retina...
  25. ncbi Comparative aspects of the strength of pulmonary capillaries in rabbit, dog, and horse
    E K Birks
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla 92093 0623
    Respir Physiol 97:235-46. 1994
    In previous studies of rabbit and dog lung, we demonstrated stress failure of pulmonary capillaries at high transmural pressures (Ptm)...
  26. ncbi Fiber capillary supply related to fiber size and oxidative capacity in human and rat skeletal muscle
    Rob C I Wüst
    Instititute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager, ST7 2HL, UK
    Adv Exp Med Biol 645:75-80. 2009
    ..e. whether it came from the deep or superficial region of the muscle (all P < 0.001) and not SDH. In conclusion, size, type and metabolic surrounding rather than mitochondrial activity determine the capillary supply to a muscle fiber...
  27. ncbi Identification of class III β-tubulin as a marker of angiogenic perivascular cells
    Peter C Stapor
    Department of Biomedical Engineering, Tulane University, Lindy Boggs Center, Suite 500, New Orleans, LA 70118 5698, USA
    Microvasc Res 83:257-62. 2012
    ..was nerve specific, and did not identify vascular cells along PECAM positive arterioles, venules, and capillaries. Two days post 48/80 stimuli, class III β-tubulin labeling of perivascular cells, including pericytes and ..
  28. pmc Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: comparison with conventional monocultures
    Jennifer Kasper
    University Medical Centre, Institute of Pathology, Mainz, Germany
    Part Fibre Toxicol 8:6. 2011
    ....
  29. pmc Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain
    Francisco Fernández-Klett
    Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, D 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 107:22290-5. 2010
    ..Prostaglandin F2α (U46619), induced constrictions in the vicinity of pericytes in a fraction of capillaries, whereas others dilated...
  30. ncbi Gas diffusion and alveolar-capillary unit in chronic heart failure
    Piergiuseppe Agostoni
    Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
    Eur Heart J 27:2538-43. 2006
    ..Diffusion depends on membrane diffusion (DM) and the amount of blood participating in gas exchange (VC). How DM, VC, and the alveolar-capillary unit behave in relationship to CHF severity is unknown...
  31. ncbi Blood-brain barrier-specific properties of a human adult brain endothelial cell line
    B B Weksler
    Institut Cochin, CNRS UMR 8104 INSERM U567, Universite Rene Descartes, Paris, France
    FASEB J 19:1872-4. 2005
    ..Thus, hCMEC/D3 represents the first stable, fully characterized, well-differentiated human brain endothelial cell line and should serve as a widely usable research tool...
  32. pmc Autocrine role for interleukin-8 in Bartonella henselae-induced angiogenesis
    Amy M McCord
    Department of Molecular Medicine, School of Basic Biomedical Science, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, MDC10, Tampa, FL 33612, USA
    Infect Immun 74:5185-90. 2006
    ..Infection of human endothelial cells by B. henselae resulting in IL-8 production likely plays a central role in the ability of this organism to cause angiogenesis during infection...
  33. pmc Functional reactivity of cerebral capillaries
    Bojana Stefanovic
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 1065, USA
    J Cereb Blood Flow Metab 28:961-72. 2008
    ..Very little data, however, exist on the functional reactivity of capillaries, the vessels most proximal to the activated neuronal population...
  34. ncbi Hydrocortisone reinforces the blood-brain properties in a serum free cell culture system
    D Hoheisel
    Institut fur Biochemie, Westfalische Wilhelms Universitat, Munster, Germany
    Biochem Biophys Res Commun 247:312-5. 1998
    ..2x10(-7) cm/s and by a factor of five lower compared to cultures without hydrocortisone and in presence of serum...
  35. ncbi Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes
    Cecilia Bondjers
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    FASEB J 20:1703-5. 2006
    ..The three new brain pericyte markers are signaling molecules implicated in ion transport and intercellular signaling, potentially opening new windows on pericyte function in brain microvessels...
  36. ncbi Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia
    T S Kern
    Departments of Medicine, Ophthalmology, Pharmacology and Center for Diabetes Research, Case Western Reserve University, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 41:3972-8. 2000
    ..To examine the relationship between early retinal capillary cell apoptosis and late histologic lesions of diabetic retinopathy and to compare the effects of aminoguanidine (AMG) on the retinopathies caused by diabetes and galactose feeding...
  37. ncbi The glomerular endothelial cell coat is essential for glomerular filtration
    Vincent Fridén
    Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    Kidney Int 79:1322-30. 2011
    ..Thus, the absence of one or more of these proteins causes proteinuria and illustrates the importance of the ECC in glomerular permselectivity...
  38. ncbi Physiologic angiodynamics in the brain
    Paula Dore-Duffy
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Antioxid Redox Signal 9:1363-71. 2007
    ..The return to normoxia is accompanied by microvascular regression and decreasing numbers of capillaries to prehypoxic densities...
  39. pmc Noninvasive visualization and analysis of parafoveal capillaries in humans
    Johnny Tam
    University of California, Berkeley and University of California, San Francisco, Joint Graduate Group in Bioengineering, Berkeley, California 94720 2020, USA
    Invest Ophthalmol Vis Sci 51:1691-8. 2010
    ..To demonstrate a noninvasive method to visualize and analyze the parafoveal capillary network in humans...
  40. ncbi Evidence of tubular hypoxia in the early phase in the remnant kidney model
    Krissanapong Manotham
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:1277-88. 2004
    ..The initial hypoxia in this model was dependent on activation of the renin-angiotensin system and hemodynamic alterations after nephron loss...
  41. ncbi Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
    P Lindahl
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 125:3313-22. 1998
    ....
  42. ncbi AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
    Daisuke Nagata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:31000-6. 2003
    ..As such, endothelial AMPK signaling may be a critical determinant of blood vessel recruitment to tissues that are subjected to ischemic stress...
  43. ncbi Manganese distribution across the blood-brain barrier. IV. Evidence for brain influx through store-operated calcium channels
    Janelle S Crossgrove
    Graduate Center for Toxicology, University of Kentucky Medical Center, Lexington, KY 40536 0305, USA
    Neurotoxicology 26:297-307. 2005
    ..This work provides evidence that store-operated Ca channels, as well as another mechanism at the blood-brain barrier, likely play a role in carrier-mediated Mn influx into the brain...
  44. pmc ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
    Zhihui Zhong
    Center for Neurodegenerative and Vascular Brain Disorders and Department of Neurosurgery, University of Rochester Medical Center, Kornberg Medical Research Bldg, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Nat Neurosci 11:420-2. 2008
    ..SOD1 mutant-mediated endothelial damage accumulated before motor neuron degeneration and the neurovascular inflammatory response occurred, indicating that it was a central contributor to disease initiation...
  45. ncbi Invited review: activity-induced angiogenesis
    Stuart Egginton
    Centre for Cardiovascular Sciences, University of Birmingham Medical School, UK
    Pflugers Arch 457:963-77. 2009
    ....
  46. pmc Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats
    Qi Guo
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 35:48-54. 2012
    ..These results indicate that losartan reverses HCTZ-exacerbated insulin resistance, which can be mediated through the modulation of muscular circulation in rats with impaired glucose metabolism...
  47. pmc Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 587:1755-67. 2009
    ..for regulating both cardiac and skeletal muscle capillarity, and that a reduced number of VEGF-dependent muscle capillaries would limit aerobic exercise capacity...
  48. pmc Functional respiratory morphology in the newborn quokka wallaby (Setonix brachyurus)
    A N Makanya
    Department of Veterinary Anatomy and Physiology, University of Nairobi, Kenya
    J Anat 211:26-36. 2007
    ..The tubules were separated by abundant intertubular mesenchyme, aggregations of developing capillaries and mesenchymal cells...
  49. ncbi Endothelial progenitor cells are integrated in newly formed capillaries and alter adjacent fibrovascular tissue after subcutaneous implantation in a fibrin matrix
    Oliver Bleiziffer
    Department of Plastic and Hand Surgery, University Hospital Erlangen, Erlangen, Germany
    J Cell Mol Med 15:2452-61. 2011
    ..EPC may hold promise to modulate blood vessel formation in bioartificial matrices...
  50. pmc Lymphatic/Blood endothelial cell connections at the capillary level in adult rat mesentery
    Jennifer L Robichaux
    Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118 5698, USA
    Anat Rec (Hoboken) 293:1629-38. 2010
    ..growth, the objective of this study was to characterize the spatial relations between lymphatic and blood capillaries in adult rat mesenteric tissue...
  51. ncbi Effects of Type II diabetes on capillary hemodynamics in skeletal muscle
    Danielle J Padilla
    Dept of Anatomy Physiology, College of Veterinary Medicine, 228 Coles Hall, 1600 Denison Ave, Manhattan, KS 66506 5802, USA
    Am J Physiol Heart Circ Physiol 291:H2439-44. 2006
    ..We hypothesized that Type II diabetes would reduce the proportion of capillaries supporting continuous RBC flow and RBC hemodynamics within the spinotrapezius muscle of the Goto-Kakizaki Type ..
  52. pmc Shedding of the endothelial glycocalyx in arterioles, capillaries, and venules and its effect on capillary hemodynamics during inflammation
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, University Park, 16802, USA
    Am J Physiol Heart Circ Physiol 301:H2235-45. 2011
    ..with reductions in thickness of the barrier to 70-kDa dextran of 110, 80, and 123 nm, in arterioles, capillaries, and venules, respectively...
  53. ncbi Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Medicine, 1 7 1 Sakamoto, Japan
    J Biol Chem 278:8244-9. 2003
    ..Considered collectively, Shh induced capillary morphogenesis of endothelial cells through both rapid activation of c-Fes/PI3-kinase pathways and transcriptionally regulated pathways...
  54. pmc Reduced skeletal muscle capillarization and glucose intolerance
    Steven J Prior
    Baltimore Geriatric Research, Education and Clinical Center, VA Maryland Health Care System, Baltimore, Maryland 21201, USA
    Microcirculation 16:203-12. 2009
    ..We hypothesized that compared to sedentary controls, stroke subjects have reduced skeletal muscle capillarization that is associated with glucose intolerance and reduced peak oxygen consumption (Vo(2peak))...
  55. ncbi Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes
    O Skalli
    Department of Pathology, University of Geneva, Switzerland
    J Histochem Cytochem 37:315-21. 1989
    ..In SMC and pericytes, alpha-sm actin was localized in microfilament bundles, strengthening the assumption that it is the functional isoform in these cell types and supporting the assumption that pericytes exert contractile functions...
  56. ncbi Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes
    L Zheng
    Department of Medicine, 448B Biomedical Research Building, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Diabetologia 50:1987-96. 2007
    ..The aim of this study was to investigate the role of iNOS in the pathogenesis of the early stages of diabetic retinopathy using iNOS-deficient mice (iNos (-/-))...
  57. ncbi Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies
    Luca Cucullo
    Division of Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Cereb Blood Flow Metab 28:312-28. 2008
    ..Pretreatment with ibuprofen (0.125 mmol/L) prevented BBB failure by decreasing the inflammatory response after flow cessation/reperfusion...
  58. ncbi Adenovirus-mediated PEDF expression inhibits prostate cancer cell growth and results in augmented expression of PAI-2
    Ming Guan
    Center of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China
    Cancer Biol Ther 6:419-25. 2007
    ..These results can contribute to our understanding of the molecular mechanisms of treatment strategies of PEDF for prostate cancer...
  59. ncbi Implications of immunohistochemical detection of C4d along peritubular capillaries in late acute renal allograft rejection
    Rajiv D Poduval
    Department of Medicine, Division of Nephrology, University of Chicago, Chicago, IL 60637, USA
    Transplantation 79:228-35. 2005
    Immunohistochemical detection of the C4d complement product along peritubular capillaries (PC) may indicate humoral rejection of renal allografts...
  60. ncbi Cortical electrical stimulation alters erythrocyte perfusion pattern in the cerebral capillary network of the rat
    M L Schulte
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 963:81-92. 2003
    ..The movement of fluorescently labeled red blood cells (FRBCs) in individual capillaries 50-70 microm subsurface in the dorsal somatosensory cortex was visualized using a closed cranial window...
  61. pmc Effects of angiotensin II on the pericyte-containing microvasculature of the rat retina
    Hajime Kawamura
    Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
    J Physiol 561:671-83. 2004
    ..This inhibition of gap junction-mediated intercellular communication suggests a previously unappreciated complexity in the spatiotemporal dynamics of the microvascular response to angiotensin II...
  62. ncbi Observation of erythrocyte dynamics in the retinal capillaries and choriocapillaris using ICG-loaded erythrocyte ghost cells
    Robert Flower
    Department of Ophthalmology, New York University School of Medicine, New York, USA
    Invest Ophthalmol Vis Sci 49:5510-6. 2008
    ..To find evidence of retinal vasomotion and to examine the relationship between erythrocyte dynamics and previously observed high-frequency pulsatile blood flow through the choriocapillaris...
  63. pmc Oxygen gradients in the microcirculation
    R N Pittman
    Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Acta Physiol (Oxf) 202:311-22. 2011
    ..Developments during the last 40 years are reviewed, including studies of oxygen gradients in arterioles, capillaries, venules, microvessel wall and surrounding tissue...
  64. ncbi Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries
    S Mauiyyedi
    Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 12:574-82. 2001
    ..of CR is mediated by antidonor antibody was tested by determining whether C4d is deposited in peritubular capillaries (PTC) and whether it correlates with circulating antidonor antibodies...
  65. ncbi What tangled webs they weave: Rho-GTPase control of angiogenesis
    B A Bryan
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Cell Mol Life Sci 64:2053-65. 2007
    ....
  66. ncbi Reduction of L-type amino acid transporter 1 mRNA expression in brain capillaries in a mouse model of Parkinson's disease
    Sumio Ohtsuki
    Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Biol Pharm Bull 33:1250-2. 2010
    ..Our findings indicate that decreased LAT1 expression at the BBB in PD patients may adversely affect amino acid supply from the circulating blood and levodopa distribution into the brain...
  67. ncbi How do mesangial and endothelial cells form the glomerular tuft?
    Michael R Vaughan
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    J Am Soc Nephrol 19:24-33. 2008
    ..Current concepts of the role of mesangial and endothelial cells in formation of the capillary tuft are reviewed here...
  68. pmc Structure-function studies of blood and air capillaries in chicken lung using 3D electron microscopy
    John B West
    Department of Medicine, and National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA 92093 0623, USA
    Respir Physiol Neurobiol 170:202-9. 2010
    Avian pulmonary capillaries differ from those of mammals in three important ways. The blood-gas barrier is much thinner, it is more uniform in thickness, and the capillaries are far more rigid when their transmural pressure is altered...
  69. ncbi Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries
    Veerle Matheeussen
    Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk Antwerp, Belgium
    Biol Chem 392:189-98. 2011
    ..In conclusion, our results support a highly regulated expression of individual DPPs in ECs, with a spatial heterogeneity in the cardiovascular tree...
  70. ncbi Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease
    Yuriko Matsumoto
    Division of Nephrology, Department of Medicine, Kurume University, School of Medicine, Kurume, Japan
    J Am Soc Nephrol 18:1525-33. 2007
    ..Plasma levels of ADMA were associated with decreased number of peritubular capillaries, increased tubulointerstitial fibrosis, and proteinuria levels in Nx rats...
  71. ncbi Differentiating the pathologies of cerebral malaria by postmortem parasite counts
    Terrie E Taylor
    Department of Internal Medicine, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Med 10:143-5. 2004
    ..The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology...
  72. ncbi Inosculation of tissue-engineered capillaries with the host's vasculature in a reconstructed skin transplanted on mice
    Pierre Luc Tremblay
    Laboratoire d Organogénèse Expérimentale, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital du St Sacrement and Département de Chirurgie, Quebec, Canada
    Am J Transplant 5:1002-10. 2005
    ..observed in the ERS was most probably the result of inosculation of the CLS network with the host's capillaries, rather than neovascularization, which is a slower process...
  73. ncbi Intravital videomicroscopy of peritubular capillaries in renal ischemia
    Tokunori Yamamoto
    Department of Urology, Kawasaki Medical School, Okayama 701 0114, Japan
    Am J Physiol Renal Physiol 282:F1150-5. 2002
    ..period showed intermittent cessation and partial recovery of blood flow in both peritubular and glomerular capillaries. Blood flow was uniformly orthograde under control conditions; however, the retrograde flow occurred on ..
  74. pmc Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries
    Dan Secor
    Critical Illness Research, Victoria Research Laboratories, Lawson Health Research Institute, London, ON, N6C 2V5, Canada
    Intensive Care Med 36:1928-34. 2010
    ..Since inflammatory and coagulation pathways cross-activate, we tested if stoppage of blood flow in septic capillaries is due to oxidant-dependent adhesion of platelets in these microvessels.
  75. pmc Visualization and contractile activity of cochlear pericytes in the capillaries of the spiral ligament
    Min Dai
    Oregon Hearing Research Center NRC04, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Hear Res 254:100-7. 2009
    ..Superfused K(+) and Ca(2+) to the cochlear lateral wall resulted in localized constriction of capillaries at pericyte locations both in vivo and in vitro, while there was no obvious change in cochlear capillary ..
  76. pmc Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice
    Riikka Kivela
    LIKES Research Center for Sport and Health Sciences, Rautpohjankatu 8a, 40700 Jyväskylä, Finland
    Cardiovasc Diabetol 7:13. 2008
    ..The responses in capillaries and muscle fibers, collected from the muscle with laser capture microdissection, were also studied separately.
  77. pmc Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms
    Cyrus M Ghajar
    Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA
    Exp Cell Res 316:813-25. 2010
    ..On their own, ECs invade their surrounding matrix, but do not form capillaries. However, in the presence of either mesenchymal stem cells (MSCs) or fibroblasts, ECs form polarized, tubular ..
  78. ncbi RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size
    Miyuki Unekawa
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 1320:69-73. 2010
    ..confocal microscopy with RBC-tracking software, we previously showed that RBC velocities in intraparenchymal capillaries of rat cerebral cortex are distributed over a wide range...
  79. ncbi Effect of noise exposure on blood-labyrinth barrier in guinea pigs
    Mitsuya Suzuki
    Department of Otolaryngology, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, 113 8655, Japan
    Hear Res 164:12-8. 2002
    ....
  80. pmc A hybrid model for three-dimensional simulations of sprouting angiogenesis
    Florian Milde
    Computational Science and Engineering Laboratory, ETH Zurich, Switzerland
    Biophys J 95:3146-60. 2008
    ..Extensive parametric studies reveal the role of the extracellular matrix structure and the distribution of the different vascular endothelial growth factors isoforms on the dynamics and the morphology of the generated vascular networks...
  81. ncbi Overexpression of von Hippel-Lindau protein in skeletal muscles of patients with chronic obstructive pulmonary disease
    K Jatta
    Department of Clinical Medicine, Orebro University, Sweden
    J Clin Pathol 62:70-6. 2009
    ..A significant number of patients with chronic obstructive pulmonary disease (COPD) exhibit skeletal muscle wasting and decreased capillary area formation, which correlate with increased mortality...
  82. ncbi Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead
    Victor W M van Hinsbergh
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    Cardiovasc Res 78:203-12. 2008
    ..Better understanding of the various activities of proteases may be helpful in developing more specific inhibitors that could result in tailor-made modification of proteolytic activities in disease...
  83. ncbi Basement membranes: structure, assembly and role in tumour angiogenesis
    Raghu Kalluri
    Center for Matrix Biology, Department of Medicine, Dana 514, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Rev Cancer 3:422-33. 2003
    ..Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies...
  84. ncbi Use of nanoparticles for cerebral cancer
    Jorg Kreuter
    Institute for Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Tumori 94:271-7. 2008
    ....
  85. ncbi Pericyte migration from the vascular wall in response to traumatic brain injury
    P Dore-Duffy
    Department of Neurology, Detroit Medical Center, MI 48201, USA
    Microvasc Res 60:55-69. 2000
    ..Nonmigrating pericytes in the same section displayed cytoplasmic alterations and nuclear chromatin changes consistent with a rapid degenerative process...
  86. ncbi Narrow band imaging with magnifying colonoscopy as diagnostic tool for predicting histology of early colorectal neoplasia
    A Katagiri
    Division of Gastrointestinal Oncology and Digestive Endoscopy, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Aliment Pharmacol Ther 27:1269-74. 2008
    ..The presence of abnormal microcapillaries detected by narrow band imaging (NBI) with magnifying colonoscopy has been reported to be a marker of colorectal neoplasia...
  87. pmc Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature
    Xiaofang Chen
    Department of Biomedical Engineering, University of California Irvine, Irvine, California 92697 2715, USA
    Tissue Eng Part A 15:1363-71. 2009
    ..We hypothesized that prevascularizing a tissue construct with networks of well-formed capillaries would accelerate functional anastomosis with the host upon implantation...
  88. ncbi Strategies to enhance capillary formation inside biomaterials: a computational study
    Ehsan Jabbarzadeh
    Department of Chemical Engineering, Drexel University, 3141 Chestnut St, Philadelphia, PA 19104, USA
    Tissue Eng 13:2073-86. 2007
    Control over angiogenesis (formation of new capillaries from preexisting vessels) is often a crucial requirement for implantable porous biomaterials serving as scaffolds for tissue regeneration...
  89. pmc Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting
    Amina A Qutub
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    BMC Syst Biol 3:13. 2009
    Angiogenesis, the growth of capillaries from preexisting blood vessels, has been extensively studied experimentally over the past thirty years...
  90. ncbi Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model
    William W Spurbeck
    Departments of Surgery and Hematology Oncology, St Jude Children s Research Hospital, 332 S Lauderdale, Memphis, TN 38105, USA
    Blood 100:3361-8. 2002
    ....
  91. ncbi Intussusceptive angiogenesis--the alternative to capillary sprouting
    Peter H Burri
    Institute of Anatomy, University of Berne, Buhlstrasse 26, CH 3012, Berne, Switzerland
    Mol Aspects Med 23:S1-27. 2002
    ..Although numerous growth factors and receptors have already been suggested as being active in IA, very few hard facts are at present available which would allow to get a comprehensive view of IA regulation...
  92. pmc Human CD34/CD90 ASCs are capable of growing as sphere clusters, producing high levels of VEGF and forming capillaries
    Francesco De Francesco
    Dipartimento di Medicina Sperimentale, Sezione di Istologia ed Embriologia, Tissue Engineering and Regenerative Medicine Laboratory, Seconda Universita di Napoli, Napoli, Italy
    PLoS ONE 4:e6537. 2009
    ..Human adult adipose tissue is an abundant source of mesenchymal stem cells (MSCs). Moreover, it is an easily accessible site producing a considerable amount of stem cells...
  93. ncbi Malpighi and the discovery of capillaries
    J M S Pearce
    Department of Neurology, Hull Royal Infirmary and Hull York Medical School, Hull, UK
    Eur Neurol 58:253-5. 2007
    Leonardo da Vinci clearly observed and described capillaries. Using the microscope, Marcello Malpighi examined the brain and major organs to demonstrate their finer anatomical features...
  94. ncbi Renal intravascular large B-cell lymphoma localized only within peritubular capillaries. Report of a case
    Naoki Sawa
    Department of Nephrology, Toranomon Hospital, Tokyo, Japan
    Intern Med 46:657-62. 2007
    ..For the latter cases with renal dysfunction and marked bilateral nephromegaly but without proteinuria, intravascular lymphoma within intra-peritublar capillaries should be considered as a possible diagnosis.
  95. ncbi Phosphate transport by capillaries of the blood-brain barrier
    L Dallaire
    Laboratoire de Membranologie Groupe de Recherche en Biothérapeutique Moléculaire, Université du Québec Montréal
    J Biol Chem 267:22323-7. 1992
    b>Capillaries were isolated from bovine brain cortex and used for phosphate transport studies. The influx of phosphate through capillary membranes was studied by incubation with [32Pi]phosphate followed by a rapid filtration technique...
  96. ncbi Diffusion limits of an in vitro thick prevascularized tissue
    Craig K Griffith
    Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697 2715, USA
    Tissue Eng 11:257-66. 2005
    ..7 to 7.2 mm. Capillaries with visible lumens sprouted in 2-3 days, reaching lengths that exceeded 500 microm within 6-8 days...
  97. ncbi C4d-positive interacinar capillaries correlates with donor-specific antibody-mediated rejection in pancreas allografts
    Jose R Torrealba
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53792 3224, USA
    Transplantation 86:1849-56. 2008
    ..To characterize the deposition of C4d in PTx, we analyzed 27 PTx biopsies from 18 patients transplanted between 2004 and 2007 at the University of Wisconsin...
  98. ncbi Injury and progressive loss of peritubular capillaries in the development of chronic allograft nephropathy
    Yasuo Ishii
    Department of Surgery, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Kidney Int 67:321-32. 2005
    ..However, the mechanism for graft dysfunction and the process of the development of CAN are not well understood. This study examined the role of microvascular injury in the development of CAN...
  99. ncbi Mechanisms in the loss of capillaries in systemic sclerosis: angiogenesis versus vasculogenesis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    J Cell Mol Med 14:1241-54. 2010
    ..with progressive and irreversible structural changes in multiple vascular beds culminating in the loss of capillaries. A severe imbalance between pro-angiogenic and angiostatic factors may also lead to impaired angiogenic ..
  100. pmc Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis
    I Mark Olfert
    Department of Medicine, University of California, San Diego, La Jolla, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1059-67. 2010
    ..However, skeletal muscle metabolic adaptation to exercise training takes place independent of myocyte VEGF expression...
  101. ncbi Novel three-dimensional analysis tool for vascular trees indicates complete micro-networks, not single capillaries, as the angiogenic endpoint in mice overexpressing human VEGF(165) in the brain
    Stefan Heinzer
    Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
    Neuroimage 39:1549-58. 2008
    ..cerebral blood flow is not increased in mice exhibiting a 2- to 3-fold higher density of normal and perfused capillaries as a result of transgenic overexpression of the human vascular endothelial growth factor (VEGF(165))...

Research Grants100

  1. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT SUMMARY: The structure and function of alveolar capillaries are deranged in pulmonary emphysema...
  2. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..The chemical signaling that controls the capillaries'diameter primarily originates from astrocytes, glial cells that surround the blood vessels and also ..
  3. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..concept became clearer to us when we observed that mice with primary lymphedema, devoid of dermal lymphatic capillaries, unexpectedly had elevated levels of circulating plasma cholesterol...
  4. Regulation of vasculature by estrogen receptors during aging in mouse models
    Margaret Markiewicz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Angiogenesis is a process of new vessel formation from pre existing capillaries or venules. It has been reported that this process is impaired in aged tissues...
  5. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
    ..However, when exposed to cultured retinal pericytes, which sheath and regulate the growth of retinal capillaries, Cyr61 induces their death by anoikis suggesting a role of Cyr61 in pathological angiogenesis...
  6. Foxf1 Transcription Factor in Development of Pulmonary Capillaries
    Vladimir V Kalinichenko; Fiscal Year: 2013
    ..Mice heterozygous for the Foxf1 null allele exhibited lung hypoplasia, decreased number of alveolar capillaries, increased apoptosis of EC, and increased mortality in the early neonatal period...
  7. Development of a novel method for inhibiting diabetic retinopathy
    David R Clemmons; Fiscal Year: 2012
    ..that inhibiting IGF-I actions by inhibiting SHPS-1/IAP association in endothelial cells in culture and in capillaries in rats inhibis pathophysiologic changes that occur in diabetic retinopathy...
  8. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..This capillary damage leads to an increase in retinal vascular permeability, localized loss of capillaries with resulting ischemia, and, in the final stage of DR, the growth of abnormal retinal blood vessels (..
  9. Mechanism and therapy for arteriovenous malformation
    Suk Paul Oh; Fiscal Year: 2013
    ..rare blood disease, contains arteriovenous malformation (AVM)-arteries and vein are directly connected without capillaries in between them-in various organs in a very high frequency compared with normal individuals...
  10. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Angiogenesis, the process of new blood vessel formation from pre-existing capillaries, is very tightly regulated and normally does not occur except during embryonic development and reparative ..
  11. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..Although ECs are not lysed by ANDV infection, ECs line capillaries of vast pulmonary alveolar beds and regulate capillary integrity...
  12. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..the CSF may be important in the transfer of pulsatile, non-continuous flow to non-pulsatile, continuous flow in capillaries, a term referred to as the brain's Windkessel mechanism...
  13. Dietary Nitrate to Augment Exercise Training Benefits in DM+PAD
    Jason David Allen; Fiscal Year: 2013
    ..Specific Aim 3a: To determine group differences in the change in gastrocnemius muscle for (a) angiogenesis (capillaries per unit area and per muscle fiber, endothelial cells with surrounding pericytes, relative fraction of type I, ..
  14. Effects of Metabolic Disorders on Bone Marrow-Derived Cell Function
    Gina C Schatteman; Fiscal Year: 2012
    ..or MCP-1;or 3) induce downstream targets of TNF1, IL-12, or MCP-1 limits their capacity to promote growth of capillaries, arterioles, or collaterals...
  15. Cellular Mechanisms of Lymphatic Muscle Contractility
    MICHAEL JOHN DAVIS; Fiscal Year: 2012
    ..Lymphatic capillaries run in parallel to blood vessels and capture excess fluid filtered out of blood capillaries...
  16. Impact of adipokines and insulin resistance on progression of prehypertension
    Cynthia Cheng; Fiscal Year: 2013
    ..2 Microvascular rarefaction (reduced number of arterioles and capillaries) is considered one of the earliest forms of target organ damage (TOD) in hypertension, and may contribute to ..
  17. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..arterioles and arteries in COPD respond to small increases in resistance at the level of the pulmonary capillaries by marked vasodilation, we recently developed a measure of the total pulmonary vascular volume (TPVV) on non-..
  18. Interaction of thrombospondin-1 with alpha9beta1 integrin in glioma angiogenesis
    Cezary Marcinkiewicz; Fiscal Year: 2012
    ..immunohistochemistry we detected the expression of a9[unreadable]1 integrin on endothelial cells forming blood capillaries in all organs of the body, and an up-regulation of its level in certain tumors including gliomas...
  19. LEUKOTRIENES AND DIABETIC RETINOPATHY
    Rose A Gubitosi-Klug; Fiscal Year: 2013
    ..Prior studies implicate that, early in the disease process;chronic inflammation damages the capillaries in the retina...
  20. The Biomechanics of the Human Posterior Sclera: Effects of Age, Sex, and Glaucoma
    Thao D Nguyen; Fiscal Year: 2013
    ..This causes deformation of the RGC axons, glia, and nourishing capillaries. At the optic nerve head, it is well established that blockade of axonal transport in RGC axons leads to their ..
  21. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..color Doppler imaging of the retrobulbar blood vessels, confocal scanning laser Doppler flowmetry of retinal capillaries, ocular perfusion pressure calculations, refraction, Pascal applanation (ocular pulse amplitude) and medical ..
  22. Lymphatic Regulation of Skin Electrolyte Metabolism and Blood Pressure
    JENS MARC TITZE; Fiscal Year: 2013
    ..Macrophages induce hyperplasia of subcutaneous lymph capillaries after sensing local Na+ or Cl- overload in the interstitium...
  23. Adult Tissue Morphogenesis: Functional Regulation of Intussusceptive Angiogenesis
    Steven Mentzer; Fiscal Year: 2013
    ..Morphometry demonstrates that the remaining lung develops 1-3 kilometers of new alveolar capillaries within 2 weeks of pneumonectomy...
  24. Role of P450 Eicosanoids in Delayed Microvascular Spasm Following Subarachnoid He
    DOMINIC AARON SILER; Fiscal Year: 2013
    ..Delayed microvascular spasm, a constriction of small resistance vessels and capillaries in the brain by an unknown cause, is associated with a significant number of patients who experience delayed ..
  25. Development of an instrument to track oxygen from blood to mitochondria in vivo
    Kenneth A Schenkman; Fiscal Year: 2013
    ..Three different compartments will be interrogated with light: capillaries, myocytes, and mitochondria...
  26. The role of cochlear pericytes in control of cochlear microcirculation
    Xiao Rui Shi; Fiscal Year: 2009
    ..We have previously found a high density of pericytes on the capillaries of the cochlear lateral wall: in the stria vascularis and spiral ligament...
  27. Thoroughfare Channels in CBF Autoregulation at High ICP
    Edwin M Nemoto; Fiscal Year: 2009
    ..the pressure in the brain is due to a pathologic CBF that is not perfusing brain tissue but rather going around capillaries in the brain...
  28. In vivo 2-photon imaging of NADH in health and disease
    Anna Devor; Fiscal Year: 2012
    ..an unprecedented opportunity to study the homeostasis and functional interactions among neurons, glia, and capillaries of the living brain...
  29. Direct and Bone-Marrow Mediated Effects of Adipose Stem Cells in Emphysema
    Irina Petrache; Fiscal Year: 2013
    ..imbalance, chronic inflammation, oxidative stress, and excessive alveolar cell death with loss of pulmonary capillaries that support the alveolar unit...
  30. STUDY OF DIABETIC RETINOPATHY
    Timothy S Kern; Fiscal Year: 2013
    ..development of at least the early stages of diabetic retinopathy, and especially the degeneration of retinal capillaries. How this capillary degeneration in diabetes is not clear, but most studies to date have focused on metabolic ..
  31. Functional Significance of the HIF1 Transcriptome in Granulosa Cells
    John H Nilson; Fiscal Year: 2013
    ..Nutrients and hormones to support follicle maturation come from capillaries in the theca layer;vascularization terminates at the basement membrane...
  32. Training-Muscle Blood Flow and Capillary Dynamics
    M Harold Laughlin; Fiscal Year: 2013
    ..The ways that exercise increases insulin sensitivity are believed to include: increased number of capillaries in skeletal muscle, changes in the kind of muscle cells present in the muscle, improved insulin-induced ..
  33. IL-1 beta Signaling in Diabetic Retinopathy
    Susanne Mohr; Fiscal Year: 2010
    ..of either caspase-1 or interleukin-1beta signaling prevents the formation of diabetes-induced acellular capillaries raising the possibility that interleukin-1beta production and signaling might play an important role in the ..
  34. Kidney pericytes in vascular regeneration after injury
    Jeremy S Duffield; Fiscal Year: 2010
    ..In recently published studies, we have described pericytes as an integral component of peritubular capillaries. Pericytes are cells of mesenchymal origin that lie adjacent to and make functional connections with ..
  35. MiR-26a, endothelial cells, and neovascularization
    Mark W Feinberg; Fiscal Year: 2013
    ..stimuli, vascular endothelial cells (ECs) are activated to migrate and proliferate to form primary capillaries. However, despite the importance of ECs in neoangiogenesis, our understanding of the mechanisms regulating this ..
  36. CRCNS:US French Coll:Computational Imaging of the Aging Cerebral Microvasculature
    Bradley P Sutton; Fiscal Year: 2013
    ..wastes between blood and tissue occurs in the micro-vascular vessels, extending from the arterioles through the capillaries and into the venules...
  37. Profilin-1 phosphorylation in neovascularization
    Yi Fan; Fiscal Year: 2013
    ..Furthermore, Pfn-1 phosphorylation is robustly and preferentially induced in the capillaries of infarcted cardiac tissue in human MI patients...
  38. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
    ..the instrument with a piezo-driven reference mirror for measurement of power Doppler signals from fine retinal capillaries. The system will be installed at UPMC for a two-stage clinical trial including initial validation in subjects ..
  39. Metabolome and proteome profiles of emphysema and airway disease
    RUSSELL PAUL BOWLER; Fiscal Year: 2012
    ..compliance) of the lung tissue, from destruction of structures supporting the alveoli, and destruction of capillaries feeding the alveoli. Emphysema is best detected using a high resolution CT scan...
  40. Regulation of the anti-antiangiogenic switch by CD36, Thrombospondin, and HRGP
    Roy L Silverstein; Fiscal Year: 2012
    ..These are the cells that form the lining of blood capillaries. Angiogenesis is a critically important process in the development of many human diseases, including heart ..
  41. Microvascular Endothelial Cells in the Pathogenesis of Chronic Kidney Injury
    Ikuyo Yamaguchi; Fiscal Year: 2011
    My long-term objective is to understand how renal peritubular capillaries contribute to renal fibrosis, the final common pathway of all chronic kidney diseases...
  42. Role of Cortical Microvascular Lesions in Amyloid-Beta Accumulation
    Chris B Schaffer; Fiscal Year: 2010
    ..We will produce microvascular clots and hemorrhages in individual cortical penetrating arterioles and capillaries in transgenic AD mice that express amyloid precursor protein (Mo/HuAPP695swe) and mutant presenilin1 (PS1-dE9), ..
  43. Signaling Mechanism of Platelet Glycoprotein Ib-IX
    Xiaoping Du; Fiscal Year: 2013
    ..glycoprotein Ib-IX complex (GPIb-IX) plays an important role in platelet adhesion, particularly in arteries and capillaries. At sites of vascular injury, GPIb-IX interacts with the subendothelium-bound von Willebrand factor (VWF)...
  44. Mechanisms of rapid paravascular fluid transport in the brain
    Jeffrey J Iliff; Fiscal Year: 2012
    ..cleared from brain extracellular fluid by its transport along the basal lamina, a sheath that surrounds brain capillaries. Previous studies suggest that fluid flow along the basal lamina communicates with the subarachnoid CSF ..
  45. Role of TRP channels in secondary injury after brain trauma
    VLADIMIR GERZANICH; Fiscal Year: 2013
    ..In SA2, we will examine physiological modulation of the channel in freshly isolated CNS capillaries from TBI-mice, and in cultured endothelial cells exposed to a "trauma-like" mechanical stimulus (stretch), and ..
  46. Thyroid hormone regulation of vasculature in adult myocardium
    Anthony Martin Gerdes; Fiscal Year: 2010
    ..SA involves sprouting and proliferation of new capillaries from existing vessels and IA involves septation and division of existing vessels with limited cell ..
  47. Cell-Cell Interactions In The Retinal Vasculature
    PATRICIA ANN D'AMORE; Fiscal Year: 2013
    ..observations indicate that interactions between endothelial cells and pericytes, the two cell types that form capillaries, are central to the health and function of the retinal vasculature...
  48. Selectin inhibitor therapeutics for blood flow related complications of diabetes
    John L Magnani; Fiscal Year: 2010
    ..E-selectin inhibitors for their potency in inhibiting leukostasis and increasing blood flow in retinal capillaries (Specific Aim 1.2), and preventing nephropathy (Specific Aim 1.3)...
  49. A Tissue Implantable Microbiosensor
    Peter A Petillo; Fiscal Year: 2012
    ..The design can be extended to multiple conjoined capillaries to provide an array of biosensors for the simultaneous monitoring of multiple analytes, with high temporal and ..
  50. Microthrombus Formation Triggers Lung Injury in Sepsis
    BRUCE ALLAN HARMS; Fiscal Year: 2012
    ..We hypothesize that the trigger is microthrombus formation within alveolar capillaries early in sepsis, and further hypothesize that agents that prevent microthrombus formation may prevent the ..
  51. Mechanism of Myocardial Angiogenesis in Transgenic/Knockout Animals
    Nilanjana Maulik; Fiscal Year: 2010
    ..is potentially important for the treatment of ischemic heart and limb ischemia which includes formation of capillaries (angiogenesis) and collateral arteries...
  52. Antibodies to Define Molecular Mechanisms of Hypertriglyceridemia
    Stephen G Young; Fiscal Year: 2010
    ..Fortunately, recent discoveries on the mechanism by which LPL enters capillaries may uncloak the mystery...
  53. Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara
    J Marc Simard; Fiscal Year: 2013
    ..the pore-forming subunits of the NC(Ca-ATP) channel, SUR1 and TRPM4, are prominently up-regulated in neurons, capillaries and venules in cortical regions with overlying SAH;(ii) cortical regions that show up-regulation of SUR1 and ..
  54. Signals for Post-pneumonectomy Compensatory Lung Growth
    Connie C W Hsia; Fiscal Year: 2013
    ..compensation might be explained by elevated lobar perfusion via increased strain/shear on alveolar capillaries. Lobar expansion may also alter and interact with regional perfusion...
  55. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..mice that have 1) undergone an ischemia/reperfusion injury model that results in vasodegeneration of retinal capillaries or 2) been made diabetic with STZ. Control CD34+ cells will be from non-diabetic age matched subjects...
  56. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    Jordan S Pober; Fiscal Year: 2013
    ..hypothesis to be tested has three components: (a) that disruption of TJs in ECs that line the continuous capillaries in sepsis and related conditions produces capillary leak, a major mechanism of organ injury and dysfunction;(b) ..
  57. Leucine Type Amino Acid Transport In Gliomas
    MARK MYRON GOODMAN; Fiscal Year: 2012
    ..Our approach will focus on anti-[18F]FACBC, a non-metabolized amino acid (AA) that moves across tumor capillaries involving primarily the "L" large-neutral AA transport system (LAT)...
  58. Elucidating the mechanisms of venous reprogramming during coronary development
    MARY K RED-HORSE; Fiscal Year: 2011
    ..Subsequently, the vessels differentiate into arteries, capillaries, or veins depending on their location within the heart...
  59. Adaptive Optics Instrumentation for Advanced Ophthalmic Imaging
    David R Williams; Fiscal Year: 2012
    ..structures in the living eye including the RPE cell mosaic, single leucocytes flowing in the smallest retinal capillaries, and fluorescently-labelled ganglion cell dendrites, axons and cell bodies...
  60. Development of predictive in vitro model of drug absorption across the human BBB
    Damir Janigro; Fiscal Year: 2010
    ..The BBB is formed by brain capillaries that look like simple tubes of endothelial cells...
  61. Development of a Photoactivated Respiratory Support Device
    Richard Gilbert; Fiscal Year: 2009
    ..in blood flowing through a microchannel system, which is structurally and functionally similar to pulmonary capillaries. The overall goal of this proposal is build on this preliminary experience in order to develop a microfluidic ..
  62. Mechanisms of Renal Lipotoxicity and Injury in Obesity and Diabetes
    Jesus H Dominguez; Fiscal Year: 2013
    ..PSFA and oxLDL stimulate expression of LOX-1, a transporter that internalizes oxLDL and PSFA in renal capillaries and tubules...
  63. Targeting microtubule stabilization to reduce breast tumor metastasis
    Stuart S Martin; Fiscal Year: 2013
    ..as carcinomas from epithelial cells, whose large size and rigidity often lead to their fragmentation in narrow capillaries. This restraint on metastatic efficiency could impose a selective pressure for circulating carcinoma cells to ..
  64. Role of TSC-mTORC1 pathway for podocyte injury in diabetic nephropathy
    Ken Inoki; Fiscal Year: 2013
    ..foot processes comprise the slit diaphragm, a barrier for repelling serum proteins on the surface of glomerular capillaries. Podocyte injury may produce micro-albuminuria, an early feature of DN...
  65. White matter hypoxia in a novel model of MMP-mediated inflammation in SHR/SP
    GARY ALLEN ROSENBERG; Fiscal Year: 2013
    ..lead to oligodendrocyte death and to determine the relationship of white matter ptO2 to damage to the cerebral capillaries;and 3) To test potential therapeutic agents to reduce white matter damage and improve behavior by interfering ..
  66. KLF4 and Transcriptional Control of Neovascularization
    Anne Hamik; Fiscal Year: 2013
    ..Cerebral microvessels and tracheal mucosal capillaries are increased in density;the cause of this is yet unknown and will be a topic for futue studies...
  67. Exercise as a novel strategy to target methamphetamine-induced cerebrovascular to
    Michal Toborek; Fiscal Year: 2013
    ..disruption of tight junction proteins, and alterations of caveolae-associated redox signaling in brain capillaries. Caveolae are the subset of lipid rafts that are characterized by the presence of caveolin proteins...
  68. Ultrasound-Induced Pulmonary Hemorrhage During Diagnostic Examination of the Lung
    DOUGLAS LAWRENCE MILLER; Fiscal Year: 2013
    ..is that DUS-PH starts from the direct impingement of ultrasound pulses on the blood-air barrier of pulmonary capillaries with hemorrhage resulting from capillary stress...
  69. Pericyte-endothelial cross talk in vascular stability after kidney injury
    STUART JAMES SHANKLAND; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pericytes, mural cells of the kidney peritubular capillaries, have been neglected until recently, and their function in kidney development, homeostasis, pathology and regeneration is only starting to ..
  70. The role of satellite cells in adult skeletal muscle growth and maintenance
    Charlotte A Peterson; Fiscal Year: 2013
    ..were protected against ischemia-induced damage showed a trend towards a greater number of CD31 immunostained capillaries compared to vehicle-treated mice...
  71. Renal Stroma Derived Endothelial Precursors are Critical for Renal Development
    Sunder Sims-Lucas; Fiscal Year: 2013
    ..endothelial cells gave rise to a significant portion of the peritubular capillary network, but not glomerular capillaries. Functionally, embryonic stroma-positive cells differentiated into tubular networks that expressed endothelial ..
  72. Dysfunction of endothelial precursor subtypes dictates the outcomes of diabetic r
    MARIA BARTOLOMEO GRANT; Fiscal Year: 2013
    ..function then either population alone in models of retinal ischemia-reperfusion injury or in acellular capillaries in diabetic SCID mice...
  73. Compound 49b Prevents Retinal Endothelial Cell Death Through IGFBP-3 Levels
    Jena J Steinle; Fiscal Year: 2013
    ..Our preliminary data suggest that compound 49b prevents the formation of degenerate capillaries, which involves degenerate capillary formation, which are the hallmark pathology noted in the diabetic retinal ..
  74. Creating a 3D dynamic in vitro model of the tumor microenvironment to characteriz
    LUIS FERNANDO ALONZO; Fiscal Year: 2013
    ..with tissue engineering to create a 3D tissue model of the tumor microenvironment with perfused human capillaries. This model will be able to replicate the physiology of the in vivo tumor microenvironment;thus providing ..
  75. NO Dysregulation of the Peripheral Clock in Diabetic Complications
    MARIA BARTOLOMEO GRANT; Fiscal Year: 2013
    ..cells and by 4 months of T2D resulted in the hallmark feature of diabetic retinopathy (DR), acellular retinal capillaries. Diabetic BMPC dysfunction was corrected by increasing levels of bioavailable nitric oxide (NO) towards normal ..
  76. Microscopic imaging of neuro-capillary coupling in brain cortex
    Jonghwan Lee; Fiscal Year: 2013
    ..with single-cell resolution (Specific Aim 1a), simultaneous imaging of blood flow speed over hundreds of capillaries with single-capillary and 1-s resolution (Specific Aim 1b), and imaging of fast optical signals of neuronal ..
  77. Tissue-specific stem cells and breast cancer tissue tropism
    Shelly R Peyton; Fiscal Year: 2013
    ..it ws generally accepted that distant sites of metastasis were well-vascularized and had exceedingly narrow capillaries to physically trap circulating cells;however, Paget's findings can not be explained by vascularization ..
  78. Exercise-mediated protection against brain metastases
    Michal Toborek; Fiscal Year: 2013
    ..Tight junctions are the critical components of the brain capillaries which regulate the integrity of the blood-brain barrier...
  79. Function of Cerebral Cavernous Malformation Proteins
    Gary L Johnson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cerebral cavernous malformations (CCM) are clusters of leaky, dilated capillaries causing seizures, stroke, and neurological deficits. CCMs...
  80. Endoglin Regulates Endothelial Survival and Capillary Tube Stability
    Nam Y Lee; Fiscal Year: 2013
    ..the following hypothesis: Endoglin associates with GIPC to promote angiogenesis by stabilizing endothelial capillaries via BMP-9-dependent Akt activation while destabilizing capillaries via TGF-[unreadable]-dependent suppression ..
  81. Long-term Luminescence-based Glucose Monitoring
    NATALIE ANN WISNIEWSKI; Fiscal Year: 2013
    ..Tiny, soft and porous tissue-integrating biosensors that encourage capillaries to grow in and throughout the entire cross section of the sensor are being developed to allow reliable sensor ..
  82. Microscale Oxygenation Mapping During Stroke
    Andrew K Dunn; Fiscal Year: 2013
    ..use these tools to quantify the longitudinal oxygen gradients from surface and penetrating arterioles through capillaries and draining venules under baseline conditions and after occlusion of a single arteriole...
  83. Notch mediated arterial-venous specification in the mammalian cerebrovasculature
    Corinne Nielsen; Fiscal Year: 2013
    ..Arteries carry blood from the heart to capillaries, successively reducing vessel caliber...
  84. Development of Novel Fluorinated Amino Acids
    Mark Goodman; Fiscal Year: 2004
    ..focus on the development of [18F]cyclobutyl and [18F]branched nonmetabolized amino acids that move across tumor capillaries by carrier-mediated facilitated transport involving either the "L" large-neutral amino acid or "A" alanine ..
  85. DEVELOPMENT OF AN INTELLIGENT SAMPLE INTRODUCTION SYSTEM FOR MASS SPECTROMETRY
    JUSTIN MICHAEL WISEMAN; Fiscal Year: 2013
    ..for this device is the Liquid Micro junction Surface Sampling Probe (LMJSSP), a set of coaxial microfluidic capillaries that are pumped and aspirated to bring solvent to and away from a surface of interest, where micro extraction ..
  86. MOLECULAR MECHANISMS IN NEPHROTIC SYNDROME
    William Smoyer; Fiscal Year: 2001
    ..effacement) of the distal "foot" processes of glomerular epithelial cells (GEC) that surround glomerular capillaries. Foot processes are an essential part of the kidney's filtration barrier, and their structure is regulated ..
  87. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..The high pressure pushes fluid out of the capillaries faster that the lymphatic vessels can drain the fluid from the lungs...
  88. Molecular pathogenesis of brain arteriovenous malformation
    Rong Wang; Fiscal Year: 2013
    ..AVMs are characterized by abnormal AV shunts that displace intervening capillaries. We propose a cross-disciplinary approach, fusing cutting-edge mouse genetics and imaging technologies, to test ..
  89. (PQD5) Development of in Vitro Vascularized Microtumors for Drug Screening
    Christopher C W Hughes; Fiscal Year: 2013
    ..new bioengineering approach to drug screening that employs arrayed human 3D microtumors, supported by perfused capillaries. Tumor cells grow within a small chamber filled with complex ECM and stromal cells, and are nourished by a ..
  90. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..Mechanical stress injury of the pulmonary capillaries has been shown to be important in the development of HAPE, but how the pulmonary capillaries are exposed to ..
  91. Diagonal Capillary Electrophoresis for Phosphorylation and Sialylation Analysis
    Norman J Dovichi; Fiscal Year: 2013
    ..Analytes that are not modified by the reactor will have identical migration times in the two capillaries and will generate spots that fall on the diagonal in a reconstructed two-dimensional electropherogram...
  92. CMV ACCESSORY GENES AND RETINAL CELL INFECTION
    Lenore Pereira; Fiscal Year: 1999
    ..It begins in the retinal capillaries and spreads directionally through the retina to the polarized retinal pigment epithelium (RPE)...
  93. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2004
    ..In particular, we have gained insights into the role capillaries in regulating MBF...
  94. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2002
    ..In particular, we have gained insights into the role capillaries in regulating MBF...
  95. Copper's Role in Brain LRP-mediated Abeta Efflux and Aging
    Rashid Deane; Fiscal Year: 2010
    ..The role of Cu on soluble A[unreadable] (monomers and oligomers) LRP binding and internalization in mouse brain capillaries. Aim 4. The role of Cu on LRP levels, synthesis and turnover in human brain endothelial cells...
  96. Formulation and Standardization of a Sickle Cell Disease Drug for Clinical Trial
    Robert Swift; Fiscal Year: 2010
    ..polymers inside red blood cells (RBCs), which deforms the RBCs into rigid shapes or sickle cells that occlude capillaries and small blood vessels...
  97. In Vivo Flow Cytometry to Measure Circulating Tumor Load
    David Benaron; Fiscal Year: 2004
    ..We propose to fluorescently label cells lowing in the capillaries, via i.v...
  98. Brain Drug Delivery Using Parkinson as a Disease Model
    Victor Yang; Fiscal Year: 2005
    ..onto the dextran coating of the MION particles for localization and retention of the targeted MION onto brain capillaries. TAT, a potent cell transduction peptide derived from the HIV protein, will also be linked to the dextran ..
  99. NEUTROPHIL SEQUESTRATION AND EMIGRATION IN THE LUNG
    CLAIRE DOERSCHUK; Fiscal Year: 2001
    Neutrophil sequestration and emigration in the lungs take place primarily in the capillaries. Rolling of neutrophils does not occur at this site, because most capillary segments are narrower than neutrophils...
  100. Microvascular O2 Delivery: Impact of Erythrocyte-Released ATP
    Mary Ellsworth; Fiscal Year: 2009
    ..In the microcirculation, ATP released from RBCs in response to reduced O2 tension in capillaries or venules can function in a paracrine fashion to produce vasodilation locally as well as vasodilation that is ..