microcirculation

Summary

Summary: The circulation of the BLOOD through the microvascular network lying between the ARTERIOLES and VENULES. This network includes CAPILLARIES, metarterioles, and ARTERIOVENOUS ANASTOMOSES; and the flow of blood through this network.

Top Publications

  1. ncbi Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    Stephen Trzeciak
    Division of Cardiovascular Disease and Critical Care Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Ann Emerg Med 49:88-98, 98.e1-2. 2007
  2. ncbi The macrocirculation and microcirculation of hypertension
    Francois Feihl
    Division de physiopathologie clinique, MP 14 204, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Curr Hypertens Rep 11:182-9. 2009
  3. ncbi Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
    Micaela Zonta
    Istituto CNR di Neuroscienze and Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Viale G Colombo 3, 35121 Padova, Italy
    Nat Neurosci 6:43-50. 2003
  4. ncbi Coronary microembolization: from bedside to bench and back to bedside
    Gerd Heusch
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Essen, Germany
    Circulation 120:1822-36. 2009
  5. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
  6. ncbi The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair
    Brigitte Vollmar
    Institute for Experimental Surgery, University of Rostock, Rostock, Germany
    Physiol Rev 89:1269-339. 2009
  7. ncbi Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation
    Felicity N E Gavins
    The William Harvey Research Institute, Barts and The London, Charterhouse Sq, London, EC1M 6BQ, UK
    FASEB J 21:1751-8. 2007
  8. pmc Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice
    Shi Jiang Lu
    Stem Cell and Regenerative Medicine International, 33 Locke Drive, Marlborough, MA 01752, USA
    Cell Res 21:530-45. 2011
  9. ncbi Microcirculation and oxidative stress
    E Crimi
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Free Radic Res 41:1364-75. 2007
  10. ncbi Monitoring the microcirculation in the critically ill patient: current methods and future approaches
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 36:1813-25. 2010

Detail Information

Publications337 found, 100 shown here

  1. ncbi Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    Stephen Trzeciak
    Division of Cardiovascular Disease and Critical Care Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Ann Emerg Med 49:88-98, 98.e1-2. 2007
    ....
  2. ncbi The macrocirculation and microcirculation of hypertension
    Francois Feihl
    Division de physiopathologie clinique, MP 14 204, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Curr Hypertens Rep 11:182-9. 2009
    ....
  3. ncbi Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
    Micaela Zonta
    Istituto CNR di Neuroscienze and Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Viale G Colombo 3, 35121 Padova, Italy
    Nat Neurosci 6:43-50. 2003
    ..Taken together, our findings show that neuron-to-astrocyte signaling is a key mechanism in functional hyperemia...
  4. ncbi Coronary microembolization: from bedside to bench and back to bedside
    Gerd Heusch
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Essen, Germany
    Circulation 120:1822-36. 2009
    ..Distal protection devices can retrieve atherothrombotic debris and prevent its embolization into the microcirculation, but their effect on clinical outcome has been disappointing so far, except for saphenous vein bypass grafts...
  5. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
    ..These observations implicate astrocytes in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilation in response to increased neural ..
  6. ncbi The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair
    Brigitte Vollmar
    Institute for Experimental Surgery, University of Rostock, Rostock, Germany
    Physiol Rev 89:1269-339. 2009
    ..of the liver in biosynthesis, metabolism, clearance, and host defense are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis, this requires not only a sufficient nutritive perfusion and oxygen supply, ..
  7. ncbi Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation
    Felicity N E Gavins
    The William Harvey Research Institute, Barts and The London, Charterhouse Sq, London, EC1M 6BQ, UK
    FASEB J 21:1751-8. 2007
    ..Intravital fluorescence microscopy was used to visualize the mouse cerebral microcirculation: AnxA1 null mice exhibited more white blood cell adhesion in cerebral venules than their wild-type ..
  8. pmc Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice
    Shi Jiang Lu
    Stem Cell and Regenerative Medicine International, 33 Locke Drive, Marlborough, MA 01752, USA
    Cell Res 21:530-45. 2011
    ..Since platelets contain no genetic material, they are ideal candidates for early clinical translation involving human pluripotent stem cells...
  9. ncbi Microcirculation and oxidative stress
    E Crimi
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Free Radic Res 41:1364-75. 2007
    The microcirculation is a complex and integrated system, transporting oxygen and nutrients to the cells...
  10. ncbi Monitoring the microcirculation in the critically ill patient: current methods and future approaches
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 36:1813-25. 2010
    To discuss the techniques currently available to evaluate the microcirculation in critically ill patients. In addition, the most clinically relevant microcirculatory alterations will be discussed.
  11. ncbi Prevention and treatment of microvascular obstruction-related myocardial injury and coronary no-reflow following percutaneous coronary intervention: a systematic approach
    Ronen Jaffe
    Lady Davis Medical Center, Department of Cardiology, Haifa, Israel
    JACC Cardiovasc Interv 3:695-704. 2010
    ..New approaches for prevention and treatment of MVO will require a better understanding of intracellular cardioprotective pathways such as the blockade of the mitochondrial permeability transition pore...
  12. pmc In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography
    Jia Qin
    Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
    Lasers Surg Med 43:122-9. 2011
    ....
  13. ncbi Erythropoietin improves skeletal muscle microcirculation through the activation of eNOS in a mouse sepsis model
    Raymond L C Kao
    Department of National Defense, Canadian Forces Health Services, Ottawa, Ontario, Canada
    J Trauma 71:S462-7. 2011
    ..We previously reported that administration of EPO to septic mice improves mouse skeletal muscle capillary perfusion and tissue bioenergetics. The objective of this study was to explore the potential mechanism(s) involved...
  14. ncbi Violet laser acupuncture--part 2: Effects on peripheral microcirculation
    Lu Wang
    Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine and TCM Research Center Graz, Medical University of Graz, Graz, Austria
    J Acupunct Meridian Stud 4:24-8. 2011
    Laser Doppler flowmetry for microcirculation monitoring was performed in 10 healthy volunteers (mean age ± SD: 24.9 ± 3...
  15. doi Microvascular obstruction and the no-reflow phenomenon after percutaneous coronary intervention
    Ronen Jaffe
    Schulich Heart Programme, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Suite A 253, Toronto, Ontario, Canada
    Circulation 117:3152-6. 2008
  16. ncbi Endothelial progenitor cells as therapeutic agents in the microcirculation: an update
    Claudio Napoli
    Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, 80138 Naples, Italy
    Atherosclerosis 215:9-22. 2011
    ..Overall, therapeutic angiogenesis will likely change the face of regenerative medicine in the next decade with many patients worldwide predicted to benefit from these treatments...
  17. ncbi Coronary microvascular dysfunction
    Paolo G Camici
    Medical Research Council Clinical Sciences Centre Hammersmith Hospital, and National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 356:830-40. 2007
  18. pmc Imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo
    Shengxiang Zhang
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Biol 5:e119. 2007
    ....
  19. ncbi Revascularization and microcirculation of freely grafted islets of Langerhans
    M D Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, D-66421 Homburg/Saar, Germany
    World J Surg 25:509-15. 2001
    ..The improvement of islet graft vascularization and the maintenance of adequate microvascular perfusion will contribute to the increased success of pancreatic islet transplantation...
  20. ncbi Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen
    Innocent Safeukui
    Molecular Immunology of Parasites Unit, CNRS URA 2581, Institut Pasteur, Paris, France
    Blood 112:2520-8. 2008
    ..were also retained and accumulated upstream from endothelial sinus wall slits of the open, slow red pulp microcirculation. Ten percent of rings were retained at each spleen passage, a rate matching the proportion of blood flowing ..
  21. ncbi Persistent low microcirculatory vessel density in nonsurvivors of sepsis in pediatric intensive care
    Anke P C Top
    Intensive Care, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Crit Care Med 39:8-13. 2011
    ..To investigate the time course and predictive value of microvascular alterations in children with severe sepsis...
  22. ncbi Morphometry of the human cerebral cortex microcirculation: general characteristics and space-related profiles
    Frederic Lauwers
    Functional Neuroimaging Laboratory, INSERM U825, CHU Purpan, 31059 Toulouse Cedex 3, France
    Neuroimage 39:936-48. 2008
    Studies on human brain microcirculation have thus far yielded few quantitative data, preventing the closest possible interpretation of functional imaging methods such as fMRI and PET that necessarily rely on robustly delineated morphology ..
  23. pmc Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis
    Stephen Trzeciak
    Department of Medicine, Divisions of Cardiovascular Disease and Critical Care Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza D363, Camden, NJ 08103, USA
    Intensive Care Med 34:2210-7. 2008
    ..We hypothesized that changes in microcirculatory flow during resuscitation are associated with changes in organ failure over the first 24 h of sepsis therapy...
  24. pmc Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo
    M Kamran Ikram
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1001184. 2010
    There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases...
  25. ncbi Physiology of the renal medullary microcirculation
    Thomas L Pallone
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Am J Physiol Renal Physiol 284:F253-66. 2003
    ..In this respect, DVR may differ from other parts of the efferent microcirculation of the kidney...
  26. ncbi Abnormal blood flow and red blood cell deformability in severe malaria
    A M Dondorp
    Department of Internal Medicine, Tropical Medicine and AIDS, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Parasitol Today 16:228-32. 2000
    Obstruction of the microcirculation plays a central role in the pathophysiology of severe malaria...
  27. ncbi Effects of aging and hypertension on the microcirculation
    Martin A James
    Department of Clinical Microvascular Research, Institute of Biomedical and Clinical Research, Peninsula Medical School, Exeter, United Kingdom
    Hypertension 47:968-74. 2006
    Alterations of structure and function of the microcirculation in hypertension in the elderly and changes with normotensive aging have not been fully clarified...
  28. ncbi Inhibition of sickle red cell adhesion and vasoocclusion in the microcirculation by antioxidants
    Dhananjay K Kaul
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 291:H167-75. 2006
    ..Thus SS red cell adhesion and related vasoocclusion may be ameliorated by antioxidant therapy with a stable and long-acting molecule (e.g., PNA)...
  29. ncbi Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters
    Toshiaki Iba
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, Urayasu, Chiba, Japan
    Shock 26:95-8. 2006
    Damage to the lung microcirculation and alveoli caused by activated leukocytes is known to play an important role in the development of acute lung injury (ALI)...
  30. ncbi Oxygen transport and exchange in the microcirculation
    Roland N Pittman
    Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    Microcirculation 12:59-70. 2005
    ..an adequate convective delivery of oxygen to the smallest branches of the network of blood vessels-the microcirculation-from which oxygen passes to the parenchymal cells by passive diffusion...
  31. ncbi Single-walled carbon nanotubes activate platelets and accelerate thrombus formation in the microcirculation
    Peter Bihari
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians Universitat Munchen, Marchioninistrasse 27, D 81377 Munich, Germany
    Toxicology 269:148-54. 2010
    ....
  32. ncbi Monitoring of the sublingual microcirculation in cardiac surgery using orthogonal polarization spectral imaging: preliminary results
    Andreas Bauer
    Department of Anesthesiology, Ludwig Maximilian University Munich, Germany
    Anesthesiology 107:939-45. 2007
    The recent introduction of orthogonal polarization spectral imaging enables the direct visualization of the microcirculation of man without imaging enhancing dyes...
  33. ncbi Microcirculatory dysfunction in sepsis
    David J Lundy
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Crit Care Clin 25:721-31, viii. 2009
    ..Finally, potential novel therapies and challenges in treating microcirculatory dysfunction in septic patients are discussed...
  34. pmc Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?
    Chen Ting Lee
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Int J Hyperthermia 26:232-46. 2010
    ....
  35. ncbi Intracoronary compared with intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the randomized Leipzig immediate percutaneous coronary intervention abciximab IV
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Circulation 118:49-57. 2008
    ..Intracoronary abciximab bolus application results in high local drug concentrations and may be more effective than a standard intravenous bolus...
  36. ncbi Flow-induced changes in pial artery compliance registered with a non-invasive method in rabbits
    Andrzej F Frydrychowski
    Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str 15, 80 210 Gdansk, Poland
    Microvasc Res 82:156-62. 2011
    ..This study was performed: 1) to assess the relationship between blood flow velocity in the internal carotid artery (CBF(ICA)) and pial artery pulsation (cc-TQ) and 2) to evaluate flow-induced changes in pial artery compliance...
  37. ncbi Eccentric exercises for the management of tendinopathy of the main body of the Achilles tendon with or without the AirHeel Brace. A randomized controlled trial. A: effects on pain and microcirculation
    Karsten Knobloch
    Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Germany
    Disabil Rehabil 30:1685-91. 2008
    ..To compare eccentric training and the combination of eccentric training with the AirHeel Brace for the management of tendinopathy of the main body of the Achilles tendon...
  38. ncbi Gastrointestinal microcirculation and cardiopulmonary function during experimentally increased intra-abdominal pressure
    Pia H Olofsson
    Center for Teaching and Research in Disaster Medicine and Traumatology, Linkoping, Sweden
    Crit Care Med 37:230-9. 2009
    The aim of this study was to assess gastric, intestinal, and renal cortex microcirculation parallel with central hemodynamics and respiratory function during stepwise increase of intra-abdominal pressure (IAP).
  39. ncbi Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo
    Stephanie E Wölfle
    Department of Physiology, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Cardiovasc Res 82:476-83. 2009
    ..Although EDHF is the main mediator of acetylcholine (ACh)-induced dilation in the murine skeletal microcirculation, the differential contribution of KCa3.1 and KCa2.3 is not known.
  40. ncbi Histamine regulates autoreactive T cell activation and adhesiveness in inflamed brain microcirculation
    Marilena Lapilla
    Neurological Institute Foundation, IRCCS Carlo Besta, 20133 Milan, Italy
    J Leukoc Biol 89:259-67. 2011
    ..of autoreactive T cells to ICAM-1 in vitro and blocked firm adhesion of these cells in inflamed brain microcirculation in vivo...
  41. ncbi Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock
    Vanina S Kanoore Edul
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Crit Care Med 40:1443-8. 2012
    The microcirculation of septic patients has been characterized only semiquantitatively. Our goal was to characterize the sublingual microcirculation in healthy volunteers and patients with septic shock quantitatively...
  42. pmc Ischaemic heart disease in women: are there sex differences in pathophysiology and risk factors? Position paper from the working group on coronary pathophysiology and microcirculation of the European Society of Cardiology
    Viola Vaccarino
    Emory University Rollins School of Public Health and School of Medicine, Atlanta, GA, USA
    Cardiovasc Res 90:9-17. 2011
    ..Eventually, a better understanding of these processes and mechanisms may improve the prevention and the clinical management of IHD in women...
  43. pmc The development of the heart and microcirculation: role of shear stress
    Robert E Poelmann
    Department of Anatomy and Embryology, LUMC, Leiden, The Netherlands
    Med Biol Eng Comput 46:479-84. 2008
    ..Geometry of the vascular system heavily affects the flow and shear patterns, as is the case in the adult vasculature where atheroprone areas nicely coincide with the frequency of the primary cilium as shear stress sensor...
  44. ncbi Association of TIMI myocardial perfusion grade and ST-segment resolution with cardiovascular magnetic resonance measures of microvascular obstruction and infarct size following ST-segment elevation myocardial infarction
    Evan Appelbaum
    Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Thromb Thrombolysis 27:123-9. 2009
    ..We hypothesized that myocardial perfusion, as assessed by the Thrombolysis in Myocardial Infarction (TIMI) Myocardial Perfusion Grade (TMPG), would be associated with a CMR metric of MO in this population...
  45. ncbi Effects of the Valsalva maneuver on pial artery pulsation and subarachnoid width in healthy adults
    Magdalena Wszedybyl-Winklewska
    Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str 15, 80 210 Gdansk, Poland
    Microvasc Res 82:369-73. 2011
    ....
  46. ncbi Effect of erythropoietin as an adjunct to primary percutaneous coronary intervention: a randomised controlled clinical trial
    Andrew J Ludman
    The Hatter Cardiovascular Institute, University College London, London, UK
    Heart 97:1560-5. 2011
    ..We investigated whether high-dose EPO administered as an adjunct to PPCI reduces MI size...
  47. pmc Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide
    Ryon M Bateman
    Vascular Biology Program, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Crit Care 7:359-73. 2003
    The microcirculation is a complex and integrated system that supplies and distributes oxygen throughout the tissues. The red blood cell (RBC) facilitates convective oxygen transport via co-operative binding with hemoglobin...
  48. pmc Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South Suite 406, La Jolla, CA 92037, USA
    Am J Pathol 176:1306-15. 2010
    ..Administration of nimodipine induced vasodilation and increased pial blood flow. We conclude that vasoconstriction and vascular collapse play a role in murine CM pathogenesis and nimodipine holds potential as adjunctive therapy for CM...
  49. ncbi The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis
    Stefano Fiorucci
    Dipartimento di Medicina Clinica, Patologia, Clinica di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Perugia, Italy
    Hepatology 42:539-48. 2005
    ..This effect was attenuated by H2S treatment (P < .05). The H2S-induced relaxation of hepatic microcirculation was attenuated by glibenclamide, an adenosine triphosphate (ATP)-sensitive K+ channel inhibitor...
  50. ncbi The impact of the glycocalyx on microcirculatory oxygen distribution in critical illness
    Daniel Chappell
    Clinic of Anaesthesiology, Ludwig Maximilians University Munich, Munich, Germany
    Curr Opin Anaesthesiol 22:155-62. 2009
    ..Main problems of critical illness and sepsis are an altered oxygen distribution and microvascular dysfunction linked to tissue oedema. This review seeks to analyse the role of the endothelial glycocalyx in this context...
  51. ncbi Microvascular obstruction is a major determinant of infarct healing and subsequent left ventricular remodelling following primary percutaneous coronary intervention
    Stein Ørn
    Division of Cardiology, Stavanger University Hospital, PO 8400, Stavanger 4068, Norway
    Eur Heart J 30:1978-85. 2009
    ..We studied the time-dependent relationships between microvascular obstruction (MO), infarct size, and left ventricular (LV) remodelling after acute myocardial infarction (MI)...
  52. ncbi Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes
    Alin Stirban
    Heart and Diabetes Center NRW, Georgstrasse 11, 32545 Bad Oeynhausen, Germany
    Diabetes Care 29:2064-71. 2006
    ....
  53. ncbi Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats
    Jin Zhou
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 25:878-86. 2005
    ..These compounds might be considered as potential therapeutic agents against ischemic and inflammatory diseases of the brain...
  54. ncbi Platelet and leukocyte adhesion in the microvasculature at the cerebral surface immediately after subarachnoid hemorrhage
    Mami Ishikawa
    Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Neurosurgery 64:546-53; discussion 553-4. 2009
    ..The purpose of this study was to observe platelet-leukocyte-endothelial cell interactions as indexes of inflammatory and prothrombogenic responses in the acute phase of SAH, using an in vivo cranial window method...
  55. ncbi Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, California 90017 2395, USA
    Am J Physiol Heart Circ Physiol 283:H1099-107. 2002
    ..06 +/- 0.01 ml x min(-1) x g(-1)). The development of macroscopic hemorrhage lagged behind no reflow, was closely correlated with it, and may be the consequence of microvascular damage...
  56. ncbi Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure
    Taishi Nakamura
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjyo, Kumamoto 860 8556, Japan
    Stroke 38:3016-22. 2007
    ..However, the underlying mechanism of stroke prevention by pioglitazone is unknown. Our aim was to examine the effect of pioglitazone on hypertension-based stroke in rats...
  57. ncbi Structural and biophysical simulation of angiogenesis and vascular remodeling
    R Gödde
    Institut für Regelungs und Steuerungstechnik, Universitat Siegen, Siegen, Germany
    Dev Dyn 220:387-401. 2001
    ....
  58. ncbi Biological effect of far-infrared therapy on increasing skin microcirculation in rats
    Shi Yau Yu
    Institute of Molecular and Cellular Biology, Department of Life Science, National Tsing Hua University, Hsinchu, and Division of General Surgery, Department of Surgery, Veterans General Hospital, Taipei, Taiwan
    Photodermatol Photoimmunol Photomed 22:78-86. 2006
    Insufficient microcirculation of skin leads to acute and chronic tissue ischemia in cases of trauma, reconstructive surgery, diabetes mellitus and peripheral arterial occlusive disease...
  59. ncbi Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis
    Jamie Turner
    University Division of Medicine and Therapeutics, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY Scotland, UK
    Trends Cardiovasc Med 18:109-16. 2008
    ..With its increasing use by other groups, it is anticipated that further published studies will help to provide a better understanding of the development and progression of cardiovascular disease...
  60. pmc The microcirculation: a motor for the systemic inflammatory response and large vessel disease induced by hypercholesterolaemia?
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    J Physiol 562:647-53. 2005
    ..to the inflammatory responses induced by hypercholesterolaemia and offers the hypothesis that inflammatory events initiated within the microcirculation may contribute to initiation and/or progression of large vessel disease.
  61. ncbi Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure
    G Einecke
    Alberta Transplant Applied Genomics Centre, Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 9:2520-31. 2009
    ..with late biopsies (>1 year) frequently displayed donor-specific HLA antibody (particularly class II) and microcirculation changes, including glomerulitis, glomerulopathy, capillaritis, capillary multilayering and C4d staining...
  62. ncbi Noninvasive assessment of endothelial function in the skin microcirculation
    Haythem Debbabi
    Department of Non Invasive Investigations, Cardiovascular Research Centre, PARCC Inserm U970, Lariboisiere Hospital, Paris, France
    Am J Hypertens 23:541-6. 2010
    ..The aim of this study was to determine whether the laser Doppler response of skin microcirculation to acetylcholine, reflects that of conduit artery assessed by brachial artery flow-mediated dilation (FMD).
  63. pmc Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Pharmacol Rev 60:196-209. 2008
    ..Finally, several steps in signaling are potential therapeutic targets that could be used to modulate P-glycoprotein activity in the clinic...
  64. ncbi Impact of early vs. late microvascular obstruction assessed by magnetic resonance imaging on long-term outcome after ST-elevation myocardial infarction: a comparison with traditional prognostic markers
    Suzanne de Waha
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Leipzig, Germany
    Eur Heart J 31:2660-8. 2010
    ..Furthermore, it is unclear whether the assessment of MO by MRI adds incremental prognostic information independent of traditional outcome markers...
  65. ncbi Measurement of microcirculation in optic nerve head by laser speckle flowgraphy in normal volunteers
    K Yaoeda
    Department of Ophthalmology, Niigata University School of Medicine, Niigata, Japan
    Am J Ophthalmol 130:606-10. 2000
    ..To report blood flow in the optic nerve head between the right and left eyes or the superior and inferior neuroretinal rims in normal volunteers using laser speckle flowgraphy...
  66. ncbi Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry
    K Yaoeda
    Department of Ophthalmology, Niigata University School of Medicine, Niigata, Japan
    Am J Ophthalmol 129:734-9. 2000
    ..To evaluate and compare blood flow measurements by laser speckle flowgraphy and scanning laser Doppler flowmetry in the optic nerve head of normal volunteers...
  67. ncbi Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis
    Silvia D'Alessio
    University of Florence, Florence, Italy
    Arthritis Rheum 50:3275-85. 2004
    ....
  68. ncbi Comparison of instruments for investigation of microcirculatory blood flow and red blood cell concentration
    Jim O'Doherty
    University of Limerick, Tissue Optics and Microcirculation Imaging Facility, Department of Physics, National Technology Park, County Limerick, Ireland
    J Biomed Opt 14:034025. 2009
    ..TiVi) imaging system, which is proposed as a useful tool to quantify red blood cell concentration in microcirculation. Three systems are evaluated with common skin tests such as the use of vasodilating and vasoconstricting ..
  69. pmc Endothelial dysfunction in the microcirculation of patients with obstructive sleep apnea
    Brian T Patt
    The Ohio State University Columbus, USA
    Am J Respir Crit Care Med 182:1540-5. 2010
    ..Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease. We hypothesized that patients with OSA and no cardiovascular disease have oxidant-related microcirculatory endothelial dysfunction...
  70. pmc VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation
    Sung Hee Chang
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 69:4537-44. 2009
    ....
  71. ncbi Changes in microcirculation as early markers for infection in preterm infants--an observational prospective study
    Kathrin Weidlich
    Department of Internal Medicine, General Hospital Munich, Munich Bavaria 80804, Germany
    Pediatr Res 66:461-5. 2009
    In adults with severe sepsis, the disturbances of the sublingual microcirculation can be quantified with orthogonal polarization spectral imaging...
  72. ncbi Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10
    Gustavo Batista Menezes
    Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
    J Immunol 183:7557-68. 2009
    ..This may be a mechanism to keep neutrophils in sinusoids for intravascular trapping...
  73. ncbi Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry
    M Roustit
    Inserm CIC3, Grenoble Clinical Research Center, Grenoble University Hospital, France
    Microvasc Res 79:102-8. 2010
    ..We also evaluated spatial reproducibility of both tests on the forearm. Finally, we assessed the influence of mental stress and room temperature variations on PORH and LTH...
  74. pmc Role of renal microcirculation in experimental renovascular disease
    Radu Iliescu
    The Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS, USA
    Nephrol Dial Transplant 25:1079-87. 2010
    ..We hypothesized that preserving the renal microcirculation in the stenotic kidney will halt the progression of renal damage.
  75. ncbi Macular microcirculation and macular oedema in branch retinal vein occlusion
    H Noma
    Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Yachiyo, Chiba 276 8524, Japan
    Br J Ophthalmol 93:630-3. 2009
    ..The relationship between the blood-flow velocity in the perifoveal capillaries and macular oedema was investigated in patients with branch retinal vein occlusion (BRVO)...
  76. ncbi Evaluation of microvascular endothelial function in patients with type 1 diabetes using laser-Doppler perfusion monitoring: which method to choose?
    Marilia B Gomes
    Diabetes Unit, State University of Rio de Janeiro, Brazil
    Microvasc Res 76:132-3. 2008
    ..A. et al., 2007. Evaluation of the microcirculation in hypertension and cardiovascular disease. Eur. Heart J. 28, 2834-2840]...
  77. pmc Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1
    Tanya A Rege
    Division of Neuropathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Cell Physiol 218:94-103. 2009
    ..These data identify a novel mechanism whereby TSP-1 can inhibit angiogenesis-through induction of apoptosis in a process mediated by TNF-R1...
  78. pmc Age-related changes in the hepatic microcirculation in mice
    Yoshiya Ito
    Department of Cell Biology and Anatomy, College of Medicine, P O Box 245044, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724 5044, USA
    Exp Gerontol 42:789-97. 2007
    ..hepatic blood flow is suspected to contribute this impairment, we examined age-related alterations in hepatic microcirculation. Livers of C57Bl/6 mice were examined at 0...
  79. ncbi NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
    U Ozerdem
    The Burnham Institute, 10901 North Torrey Pines Road, San Diego, CA 92307, USA
    Dev Dyn 222:218-27. 2001
    ..Additional insight into these and other aspects of vascular morphogenesis should be possible through use of NG2 as a mural cell marker...
  80. pmc Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation
    Junxi Wu
    Department of Internal Medicine, Medical Pharmacology and Physiology and Nutrition and Exercise Physiology, Dalton Cardiovascular Research Center, University of Missouri Columbia, 65211, USA
    Basic Res Cardiol 106:317-24. 2011
    ..This review will focus on (1) the interaction between inflammation and stem cells; (2) the fate of stem cells at the microcirculatory level, and their subsequent influences on stem cell-based therapies...
  81. pmc Proliferation and remodeling of the peritubular microcirculation after nephron reduction: association with the progression of renal lesions
    E Pillebout
    INSERM U426, , , 16, rue Henri Huchard, BP 416, 75870 Paris Cedex 18, France
    Am J Pathol 159:547-60. 2001
    ..was to document potential alterations in the morphology and proliferation of the renal cortical peritubular microcirculation at specific time points (7 and 60 days) after experimental 75% surgical nephron reduction using two strains ..
  82. ncbi The microcirculation and inflammation: site of action for glucocorticoids
    M Perretti
    Department of Biochemical Pharmacology, The William Harvey Research Institute, London, England
    Microcirculation 7:147-61. 2000
    ..widespread efficacy is the result of multiple modes of action occurring predominantly at the level of the microcirculation. Indeed the glucocorticoids interfere with the function of all of the cellular components of the ..
  83. ncbi Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia
    Shengxiang Zhang
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    J Neurosci 25:5333-8. 2005
    ..The relationship between microcirculation and dendritic spine structure was determined in mouse somatosensory neurons during stroke...
  84. ncbi Heterogeneous expression of cell adhesion molecules by endothelial cells in ARDS
    Annette M Müller
    Institute of Pathology, University Clinic Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    J Pathol 198:270-5. 2002
    ..There is also markedly heterogeneous expression of E-selectin and VCAM, indicating toporegional differences in the function of pulmonary ECs...
  85. ncbi Relationship between optic nerve head microcirculation and visual field loss in glaucoma
    Kiyoshi Yaoeda
    Department of Ophthalmology, Faculty of Medicine, Niigata University, Niigata City, Japan
    Acta Ophthalmol Scand 81:253-9. 2003
    ..To study the relationship between optic nerve head blood flow velocity and visual field loss in patients with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG)...
  86. ncbi Microcirculation patterns in different stages of melanoma growth
    Shiwu Zhang
    Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, PR China
    Oncol Rep 15:15-20. 2006
    Several microcirculation patterns in tumors have been reported, including vasculogenic mimicry (VM), mosaic vessels (MV) and endothelium-dependent vessels...
  87. ncbi Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Diabetes 57:1645-50. 2008
    ..We sought to examine whether microvascular lesions in the retina and in the brain are associated and whether this association differs among people with and without diabetes...
  88. ncbi Microvascular dysfunction: a potential pathophysiological role in the metabolic syndrome
    Erik H Serne
    Department of Internal Medicine, VU Medical Center, Amsterdam, The Netherlands
    Hypertension 50:204-11. 2007
  89. ncbi Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis
    M Kaya
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Hokkaido, Japan
    Clin Cancer Res 6:572-7. 2000
    ....
  90. ncbi The role of the microcirculation in acute kidney injury
    Matthieu Le Dorze
    Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin Crit Care 15:503-8. 2009
    Alterations of the renal microcirculation can promote the development of acute kidney injury through the interlinked occurrence of renal hypoxia and activation of inflammatory pathways...
  91. ncbi Cerebral white matter lesions, retinopathy, and incident clinical stroke
    Tien Yin Wong
    Department of Ophthalmology, University of Wisconsin, Madison, USA
    JAMA 288:67-74. 2002
    ..White matter lesions (WMLs) detected on cerebral imaging scans have been hypothesized to have a microvascular etiology and to precede the development of clinical stroke. However, few clinical data are available to support these hypotheses...
  92. pmc Cerebral microcirculation is impaired during sepsis: an experimental study
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R140. 2010
    ..Cerebral microcirculatory alterations may play a role; however, experimental data are scarce. This study sought to investigate whether the cerebral microcirculation is altered in a clinically relevant animal model of septic shock.
  93. ncbi Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance
    Renate T de Jongh
    Department of Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 109:2529-35. 2004
    ..We hypothesized that obesity is a primary cause of microvascular dysfunction, which may contribute to the development of these obesity-related disorders...
  94. pmc Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis
    J G G Dobbe
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Med Biol Eng Comput 46:659-70. 2008
    ..The technique was validated and compared to commercial software. The method was applied to the sublingual microcirculation in a healthy volunteer and in a patient during cardiac surgery...
  95. ncbi Effect of different dialyzer membranes on cutaneous microcirculation during hemodialysis
    M Sato
    Department of Kidney and Dialysis, Social Insurance Chukyo Hospital, 1 1 10 Sanjou, Minami Ku, Nagoya 457 8510, Japan
    Clin Nephrol 66:426-32. 2006
    Biocompatibility profiles of synthetic membranes may vary. In this prospective crossover study, we examined the effect of various membranes on cutaneous microcirculation during HD.
  96. ncbi Orthogonal polarization spectral imaging of the microcirculation during acute hypervolemic hemodilution and epidural lidocaine injection
    Huub L A van den Oever
    Department of Anesthesiology, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Anesth Analg 103:484-7, table of contents. 2006
    We used Orthogonal Polarization Spectral Imaging to examine the microcirculation of the vaginal mucosa in nine anesthetized patients during two consecutive anesthetic interventions: hypervolemic hemodilution using hydroxyethyl starch ..
  97. pmc Effect of shenfu injection on gastrointestinal microcirculation in rabbits after myocardial ischemia-reperfusion injury
    Xue Juan Zhang
    Department of Cardiology, Affiliated Hospital of Qingdao Medical University, Qingdao 266003, Shandong Province, China
    World J Gastroenterol 12:4389-91. 2006
    To investigate the effect of shenfu injection on gastrointestinal microcirculation after myocardial ischemic-reperfusion (IR) injury in rabbits and probe into the mechanism.
  98. pmc Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs
    Jiri Chvojka
    Intensive Care Unit, 1st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Alej Svobody 80, Plzen, 304 60, Czech Republic
    Crit Care 12:R164. 2008
    ..Therefore, we dynamically assessed renal haemodynamic, microvascular and metabolic responses to, and ultrastructural sequelae of, sepsis in a porcine model of faecal peritonitis-induced progressive hyperdynamic sepsis...
  99. ncbi Microcirculation and vascular reactivity during endotoxemia and endotoxin tolerance in humans
    Annelies Draisma
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Shock 31:581-5. 2009
    The purpose of the study was to investigate microcirculation and vascular reactivity during experimental endotoxemia and endotoxin tolerance in humans by comparing different methods of approach...
  100. ncbi Short-time effects of laser needle stimulation on the peripheral microcirculation assessed by laser Doppler spectroscopy and near-infrared spectroscopy
    Winfried Banzer
    Department of Sports Medicine, Johann Wolfgang Goethe University Frankfurt am Main, Frankfurt Main, Germany
    Photomed Laser Surg 24:575-80. 2006
    ..The aim of the present study was to evaluate immediate effects of a standardized laser needle stimulation over a defined acupuncture point on the microvascular blood flow and muscle oxygenation in the human forearm...
  101. ncbi Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects
    Rumiana Bakalova
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Bioconjug Chem 19:1135-42. 2008
    ..of the probe in experimental animals did not affect significantly the physiological parameters and microcirculation (e.g...

Research Grants69

  1. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..In addition, the effect of the successful treatments on the brain microcirculation will be assessed by intravital microscopy and the expression of eNOS, nNOS, iNOS and HO-1will be determined...
  2. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..development of occlusive vascular lesions, and may conceivably be linked to direct impact on the myocardial microcirculation. Understanding the mechanisms by which MetS affects the heart would facilitate development of strategies for ..
  3. Tumor Cell Arrest and Adhesion in the Microcirculation
    Bingmei M Fu; Fiscal Year: 2013
    ..The long-term goal of our research is to elucidate the relationships between microcirculation-induced mechanical factors, microvascular permeability (vascular integrity), cell adhesion molecules, nitric ..
  4. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..in the lung, characterized by hemorrhage in the parenchyma, increased alveolar spaces, decreased pulmonary microcirculation, and impaired basement membrane formation...
  5. Astrocytic Ca2+ Signaling in the Ischemic Penumbra
    Maiken Nedergaard; Fiscal Year: 2011
    ..Combined with recording of local field potential, we can simultaneously monitor local microcirculation, astrocytic Ca2+ signaling, and synaptic activity within the same field...
  6. TRP channels in regulation of vascular tone
    David X Zhang; Fiscal Year: 2013
    ..regulated relaxing factors (NO and mitochondria-derived H2O2) responsible for FMD in the human coronary microcirculation. We further propose that the signaling cascade occurs within caveolae that host novel interactions between ..
  7. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..a sequence of recognizable stages, which begin with structural and functional derangement of the retinal microcirculation even before the early clinical signs occur...
  8. Treatment of stroke with a clinically approved proteasome inhibitor
    Li Zhang; Fiscal Year: 2012
    ..the detrimental effects of delayed administration of tPA on vascular function and consequently improves microcirculation and vascular integrity...
  9. Experimental engineering of ovarian grafting to promote angiogenesis for fertilit
    GLENN LEWIS SCHATTMAN; Fiscal Year: 2010
    ..factors to stimulate endothelial cells and pericytes with the goal of accelerating the formation of a stable microcirculation in murine grafts...
  10. BIOENGINEERING DESIGN OF ARTIFICIAL BLOOD
    Marcos Intaglietta; Fiscal Year: 2011
    ..b>Microcirculation studies will use the awake hamster window chamber model, with direct measurements of O2 and NO levels, flow ..
  11. Insulin action in human cardiac and skeletal muscle microvasculature
    Zhenqi Liu; Fiscal Year: 2013
    ..insulin-mediated glucose uptake, and attenuates FFA-induced dysfunction in the coronary and skeletal muscle microcirculation in healthy humans;and 3) patients with diabetes have decreased coronary microvascular flow reserve and ..
  12. Blood Pressure -- Determinants &Controllers
    Allen W Cowley; Fiscal Year: 2012
    ..Project 5 focuses on the microcirculation and the mechanisms that control and alter organ and tissue perfusion in hypertension and the impact that ..
  13. The Role of Complement in Airway Microvascular Disease
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..systemic arterial revascularization at the time of surgery, lung transplants rely on the establishment of a microcirculation and are especially vulnerable to the effects of microvascular loss...
  14. Effect of cardioplegia and cardiopulmonary Bypass on coronary microvascular react
    Frank W Sellke; Fiscal Year: 2013
    ..responses to serotonin, endothelin-1 and thromboxane A2 will be examined after cardioplegia in the coronary microcirculation in well controlled, poorly controlled diabetic patients and age-matched non- diabetic patients...
  15. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2012
    ..This post- infarction angiogenic therapy to augment myocardial microcirculation will study three specific aims: 1) Mobilization and targeted chemokinesis of EPCs to revascularize ischemic ..
  16. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    ..Thus, it is conceivable that platelet/CTL interactions occurring within the hepatic microcirculation may direct CTLs to extravasate, reach parenchymal cells (i.e...
  17. Calcium wave propagation along microvascular endothelial tubes
    MATTHEW JOHN SOCHA; Fiscal Year: 2012
    ..by applicant): The long-term research goals of our laboratory center on defining signaling events in the microcirculation that underlie the control of oxygen and nutrient delivery to tissue with an emphasis on skeletal muscle ..
  18. L-carnitine Treatment for Vasopressor Dependent Septic Shock
    Alan E Jones; Fiscal Year: 2013
    ..We will use sidestream dark-field video-microscopy imaging of the sublingual microcirculation to directly visualize microcirculatory flow and to determine the effect of L-carnitine and placebo treatment ..
  19. Impact of adipokines and insulin resistance on progression of prehypertension
    Cynthia Cheng; Fiscal Year: 2013
    ..Prior microcirculation research in hypertension has been limited by sample size, the lack of inclusion of minority populations such ..
  20. CT imaging for the assessment of kidney injury distal to renal artery stenosis
    Lilach O Lerman; Fiscal Year: 2013
    ..Early renal dysfunction in MetS may be linked to direct impact on the renal microcirculation, but the nature and mechanisms of the renal effects of MetS have not been elucidated...
  21. NO-Zinc Signaling in Intact Pulmonary Endothelium
    CLAUDETTE MARIE ST CROIX; Fiscal Year: 2010
    ..g. pericytes) in their wall, the nature of contractile events within the microcirculation are likely to be distinct from vasoregulation of proximal pulmonary vessels...
  22. Hydrogen Peroxide and Flow-Induced Dilation of Human Coronary Microcirculation
    David D Gutterman; Fiscal Year: 2012
    ..The direct relevance to humans with chronic coronary disease provides a strong foundation for this mechanistic approach to understanding microvascular reactivity. ..
  23. Molecular Control of Gut Permeability in Trauma
    Mack H Wu; Fiscal Year: 2013
    ..The hypothesis to be tested is that inflammation in the intestinal microcirculation induces endothelial paracellular leakage and neutrophil infiltration into lamina propria leading to mucosal ..
  24. The role of cochlear pericytes in control of cochlear microcirculation
    Xiao Rui Shi; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The cochlear microcirculation is essential for normal hearing. A reduction of cochlear blood flow is involved in a number of hearing disorders...
  25. CONTROL OF INNER EAR MICROCIRCULATION
    Alfred L Nuttall; Fiscal Year: 2013
    ..A GPF- mitochondria transgenic mouse will be used to study the sound altered population of mitochondria in the process called biogenesis. ..
  26. Hydrogen Sulfide in Newborn Cerebral Circulation
    Charles W Leffler; Fiscal Year: 2013
    ..To accomplish these aims, techniques will be used that allow investigation of intact newborn cerebral microcirculation in vivo, pressurized isolated cerebral arterioles, freshly isolated cerebral microvessels and smooth muscle ..
  27. Microvascular Health and Nanoparticle Exposure
    Timothy R Nurkiewicz; Fiscal Year: 2010
    ..This is a critical consideration as the microcirculation is the principal site of origin for numerous vascular pathologies...
  28. Monitoring Red Cell Metabolism using a Lab on a Chip
    Dana M Spence; Fiscal Year: 2010
    ..ATP is a known stimulant of nitric oxide production in endothelial cells that line resistance vessels in the microcirculation. When released, this endothelium-derived NO results in the eventual relaxation of smooth muscle cells ..
  29. Microcirculation in Renovascular Hypertension
    ALEJANDRO ROBERTO CHADE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Microcirculation in Renovascular Hypertension Renal artery stenosis (RAS) is becoming a more common etiology of end-stage renal disease...
  30. Cyclophilin-CD147 interaction in autoimmune arthritis
    Stephanie L Constant; Fiscal Year: 2010
    ..diseases, including rheumatoid arthritis (RA), begins with the emigration of effector cells from the microcirculation. Suppression of inflammatory leukocyte extravasation could provide protection against joint damage in RA...
  31. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2013
    ..This model will therefore allow us to study the effect of sonothrombolysis on the macro- and the microcirculation with intervening temporal human skull bone to more closely mimic the human setting...
  32. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Wesley Dewhirst; Fiscal Year: 2013
    ..abstract_text> ..
  33. Role of Thromboxane in the Exercise Pressor Reflex in Peripheral Artery Disease
    ANNA KATHERINE LEAL; Fiscal Year: 2013
    ..to improve walking economy in patients with peripheral artery disease by increasing collateral blood flow and microcirculation expression of vasodilators and by decreasing urinary excretion of thromboxane B2, the stable metabolite of ..
  34. TRP Channel-Dependent Regulation of Arterial Tone
    Scott Earley; Fiscal Year: 2013
    Project Summary: The luminal diameter of muscular arteries and arterioles of the microcirculation is the principal site of control of vascular resistance...
  35. Atherogenic Mechanisms Associated with Hyperhomocysteinemia
    Hong Wang; Fiscal Year: 2013
    ..MC rolling/adhesion on EC will be examined in cremaster microcirculation model using intravital microscopy technology...
  36. Nitric oxide protects against microcirculatory complications of malaria
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2010
    ..A major controversy in microcirculation research is the role of NO in mediating vascular leak and pathogenesis, and our proposed studies will define ..
  37. Renal Vascular Reactivity in Hypertension
    William J Arendshorst; Fiscal Year: 2013
    ..new information that CD38 is the primary cyclase family member mediating Ca2+ signaling in the renal microcirculation and its functional significance in long-term regulation of renal vasoconstriction, Na+ retention and the ..
  38. Keratin biomaterial-based fluid for trauma resuscitation
    LUKE RUSSELL BURNETT; Fiscal Year: 2013
    ..These include the ability to restore plasma volume, microcirculation, and oxygen delivery as well as practical items such as a low cost, low to no side effects, easy ..
  39. CARBON MONOXIDE IN NEWBORN CEREBRAL CIRCULATION
    CHARLES LEFFLER; Fiscal Year: 2009
    ..To accomplish these aims, techniques allowing investigation of intact cerebral microcirculation, isolated cerebral microvessels, and primary culture of cells from newborn pigs will be employed...
  40. Eicosanoids and carbon monoxide in neonatal cerebral microcirculation
    ALIE JOSEPH KANU; Fiscal Year: 2012
    ..End of Abstract) ..
  41. Integrative Mechanisms of Adipose Tissue Dysfunction In obesity
    ROSARIO G SCALIA; Fiscal Year: 2013
    ..tissue experiences an abnormal infiltration of circulating leukocytes, a phenomenon that occurs in the microcirculation and it is associated with adipose tissue inflammation and insulin resistance...
  42. Mechanisms of Vascular Dysfunction in Cirrhosis
    Sandeep Khurana; Fiscal Year: 2012
    ..Dr. Pallone (Professor, Departments of Medicine and Physiology) is a renowned leader in microcirculation. Dr. Raufman (Chief, Division of Gastroenterology and Hepatology) has expertise in bile acid signaling...
  43. Molecular Mechanisms of Enhanced Contractility following Traumatic Brain Injury:
    Christian W Kreipke; Fiscal Year: 2011
    ..of neural circuits underlying cognitive and motoric behaviors, and 3) alterations in the brain's microcirculation that cause a persistent state of hypoperfusion and improper delivery of vital metabolites to neural tissue...
  44. CONTROL OF NEONATAL CIRCULATION
    Charles W Leffler; Fiscal Year: 2013
    ..Techniques will be used that allow investigation of intact newborn cerebral microcirculation in vivo, isolated pressurized cerebral arterioles, and freshly isolated astrocytes, microvessels and smooth ..
  45. Nitric Oxide in Tumor Angiogenesis, Microcirculation and Radiation Therapy
    Dai Fukumura; Fiscal Year: 2012
    ..This project will advance the basic understanding of NO-mediated vessel maturation and help develop novel strategies to improve the delivery of drugs and oxygen to tumors. ..
  46. Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
    STEPHEN WALTER TRZECIAK; Fiscal Year: 2012
    ..Currently, there are no novel therapies for sepsis that specifically target the microcirculation. Nitric oxide (NO) maintains microcirculatory homeostasis and patency, especially when the microcirculation ..
  47. Microcirculation in Health and Disease
    Robert L Hester; Fiscal Year: 2012
    ..Therefore, a better understanding of the mechanisms by which chronic exercise training improves muscle blood flow in obesity is important. ..
  48. Compromised microcirculation in women with Polycystic Ovary Syndrome
    NINA STACHENFELD; Fiscal Year: 2010
    ..with PCOS have greater circulating concentrations of endothelin-1 (ET-1), a potent vasoconstrictor in the microcirculation (including that of the skin), which can increase blood pressure and lead to endothelial damage...
  49. Preventing Venous Leg Ulcers with Cryotherapy: A Randomized Clinical Trial
    Teresa J Kelechi; Fiscal Year: 2013
    ..Our 9-month intervention is based on principles of heat transfer and cryotherapy theories involving microcirculation. With input from a cryotherapy expert and participants who completed the R21 pilot, we propose a sequenced ..
  50. Elafin Therapy for Lung Diseases
    Marlene Rabinovitch; Fiscal Year: 2013
    ..Project III shows, in exciting preliminary data, that elafin can protect the microcirculation in the murine tracheal transplant model, and prevent airway ischemia associated with bronchiolitis obliterans...
  51. AIBP-Mediated Cholesterol Efflux and Angiogenesis
    Longhou Fang; Fiscal Year: 2013
    ..Following reperfusion, angiogenesis and restoration of microcirculation is a critical component in the recovery of normal cardiac function...
  52. Volumetric imaging of blood perfusion and tissue morphology in the cochlea
    Ruikang Wang; Fiscal Year: 2013
    ..first time, to image the 3D distribution of dynamic blood perfusion, down to the capillary level, within the microcirculation tissue beds at an imaging depth up to 2.00mm into tissue...
  53. Cerebromicrovascular disease in elderly with diabetes
    Vera Novak; Fiscal Year: 2010
    ..Our goal is to determine prospectively mechanisms by which type 2 DM alters cerebral microcirculation and contributes to brain tissue damage and cognitive decline in the elderly. The primary hypotheses are: 1...
  54. Multiscale, Transport-Dependent NO Signaling: Cells to Vascular Networks
    Dov Jaron; Fiscal Year: 2013
    ..that will provide quantitative information regarding mechanisms governing nitric oxide (NO) activity in the microcirculation and to utilize innovative, real-time experiments to validate the model...
  55. Fibrovascular coupling in the cochlea and pericyte recruitment after noise
    Xiao Rui Shi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cochlear microcirculation is essential for normal hearing, with reduction of cochlear blood flow and disruption of blood-labyrinth barrier (BLB) involved in a number of hearing disorders...
  56. Digestive Enzymes and Microvascular Inflammation in Shock
    Geert W Schmid-Schoenbein; Fiscal Year: 2012
    ..the pancreatic digestive enzymes from the lumen of the intestine along multiple pathways into the peripheral microcirculation and the level of the associated microvascular inflammatory reaction. 2...
  57. Coronary Vasculature Progenitor Cell in Human Ischemic Heart Failure
    Annarosa Leri; Fiscal Year: 2012
    ..to correct rarefaction of resistance coronary arterioles and capillary structures by expansion of the cardiac microcirculation. If this were possible, cell therapy may be employed to interfere with ischemic injury, the prevailing cause ..
  58. Optimizing vascular protective effects of antitrypsin in COPD
    Irina Petrache; Fiscal Year: 2013
    ..and endotehlial cell apoptosis, on live cell and animal imaging of A1AT intracellular fate in the lung microcirculation, and on molecular and pharamcoligical approaches to increase the A1AT vascular retention during short- and ..
  59. VASOMOTOR CONTROL OF DESCENDING VASA RECTA
    Thomas L Pallone; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The microcirculation of the renal medulla traps NaCl and urea to facilitate urinary concentration and supplies metabolites to mitigate hypoxia...
  60. Impact of Blood Storage Duration on Physiologic Measures: RECESS Ancillary Study
    CHRISTOPHER PUTNAM STOWELL; Fiscal Year: 2013
    ..The impact of RBC storage on physiologic variables related to tissue oxygenation and the microcirculation has not been rigorously studied, nor have they been correlated with clinical outcomes...
  61. Ethanol Prevents Microvascular Dysfunction
    Ronald J Korthuis; Fiscal Year: 2010
    ..is involved in transducing signals elicited by ethanol to effect the acquisition of tolerance to I/R in the microcirculation. Our overall hypothesis is that ethanol-induced, AMPK-dependent eNOS activation serves as an important ..
  62. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
    ..Vascular integrity will be studied with intravital microscopy which allows direct observation of the cerebral microcirculation. Adequacy of cerebral oxygen delivery will be monitored by near infrared spectroscopy...
  63. Venous Ulcers: Testing Effects of Compression & Position
    Deidre Wipke Tevis; Fiscal Year: 2005
    Chronic venous insufficiency causes changes in the skin microcirculation that result in hypoxia, impaired blood flow, edema, and painful venous ulcers. Nursing management of these ulcers is an ongoing challenge...
  64. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2007
    ..with the relapsing fever spirochete Borrelia turicatae the site of entry into the CNS is the cerebral microcirculation. Relapsing fever borrelias are best known for antigenic variation due to sequential expression of variable ..
  65. Role of Musculo-Dynamics in Bone Fluid Flow, Circulation and Adaptation
    Yi Xian Qin; Fiscal Year: 2009
    ..Musculoskeletal complications, induced by reduced microcirculation in the condition during injury and functional disuse (e.g...
  66. MICROVASCULAR TRANSPORT IN THE RENAL MEDULLA
    THOMAS PALLONE; Fiscal Year: 2002
    Theories that account for renal medullary handling of solutes and water frequently neglect the role of the microcirculation. In contrast, studies shown that descending (DVR) and ascending vasa recta (AVR) have markedly different transport ..
  67. Microvascular O2 Delivery: Impact of Erythrocyte-Released ATP
    Mary Ellsworth; Fiscal Year: 2009
    ..In the microcirculation, ATP released from RBCs in response to reduced O2 tension in capillaries or venules can function in a ..
  68. ROLE OF L-ARGININE IN CONTROL OF BRAIN MICROCIRCULATION
    William Rosenblum; Fiscal Year: 1993
    We postulate 2 roles for L-Arginine in the control of brain microcirculation. Both roles are endothelium dependent and depend on the production of an endothelium derived relaxing factor ("EDRF") from L-Arginine...