pulmonary artery

Summary

Summary: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.

Top Publications

  1. ncbi Cellular and molecular pathobiology of pulmonary arterial hypertension
    Marc Humbert
    Service de Pneumologie et Reanimation Respiratoire, Centre des Maladies Vasculaires Pulmonaires, UPRES EA2705, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    J Am Coll Cardiol 43:13S-24S. 2004
  2. pmc Role for miR-204 in human pulmonary arterial hypertension
    Audrey Courboulin
    Departement de Medecine, Faculte de Medecine, Hôtel Dieude Québec, Canada
    J Exp Med 208:535-48. 2011
  3. ncbi Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007
  4. pmc Pulmonary arterial remodeling induced by a Th2 immune response
    Eleen Daley
    St Luke s Roosevelt Hospital, New York, NY 10019, USA
    J Exp Med 205:361-72. 2008
  5. pmc PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B
    Xianghuai Lu
    Department of Medicine, Atlanta Veterans Affairs, Emory University Medical Centers, Georgia, USA
    Am J Physiol Lung Cell Mol Physiol 299:L559-66. 2010
  6. pmc MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration
    Joy Sarkar
    Dept of Pediatrics, University of Illinois College of Medicine at Chicago, 60612, USA
    Am J Physiol Lung Cell Mol Physiol 299:L861-71. 2010
  7. pmc Reversal of experimental pulmonary hypertension by PDGF inhibition
    Ralph Theo Schermuly
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Clin Invest 115:2811-21. 2005
  8. pmc Alterations of cellular bioenergetics in pulmonary artery endothelial cells
    Weiling Xu
    Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 104:1342-7. 2007
  9. ncbi Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    M Sean McMurtry
    Department of Medicine and Pediatrics, University of Alberta, Edmonton, Canada
    Circ Res 95:830-40. 2004
  10. pmc Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
    M Sean McMurtry
    The Vascular Biology Group and Pulmonary Hypertension Program, University of Alberta, Edmonton, Alberta, Canada
    J Clin Invest 115:1479-91. 2005

Detail Information

Publications369 found, 100 shown here

  1. ncbi Cellular and molecular pathobiology of pulmonary arterial hypertension
    Marc Humbert
    Service de Pneumologie et Reanimation Respiratoire, Centre des Maladies Vasculaires Pulmonaires, UPRES EA2705, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    J Am Coll Cardiol 43:13S-24S. 2004
    ..Disordered proteolysis of the extracellular matrix is also evident in PAH. Future studies are required to find which if any of these abnormalities initiates PAH and which ones are best targeted to cure the disease...
  2. pmc Role for miR-204 in human pulmonary arterial hypertension
    Audrey Courboulin
    Departement de Medecine, Faculte de Medecine, Hôtel Dieude Québec, Canada
    J Exp Med 208:535-48. 2011
    Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation and reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs)...
  3. ncbi Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007
    ..This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH)...
  4. pmc Pulmonary arterial remodeling induced by a Th2 immune response
    Eleen Daley
    St Luke s Roosevelt Hospital, New York, NY 10019, USA
    J Exp Med 205:361-72. 2008
    ..muscularization, and support the clinical observations in pediatric patients and in companion animals that muscularization represents one of several injurious events to the pulmonary artery that may collectively contribute to PAH.
  5. pmc PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B
    Xianghuai Lu
    Department of Medicine, Atlanta Veterans Affairs, Emory University Medical Centers, Georgia, USA
    Am J Physiol Lung Cell Mol Physiol 299:L559-66. 2010
    ..examined the molecular mechanisms involved in PPARγ-regulated, hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells (HPASMC)...
  6. pmc MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration
    Joy Sarkar
    Dept of Pediatrics, University of Illinois College of Medicine at Chicago, 60612, USA
    Am J Physiol Lung Cell Mol Physiol 299:L861-71. 2010
    Hypoxia stimulates pulmonary artery smooth muscle cell (PASMC) proliferation...
  7. pmc Reversal of experimental pulmonary hypertension by PDGF inhibition
    Ralph Theo Schermuly
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Clin Invest 115:2811-21. 2005
    ..This regimen offers a unique novel approach for antire-modeling therapy in progressed pulmonary hypertension...
  8. pmc Alterations of cellular bioenergetics in pulmonary artery endothelial cells
    Weiling Xu
    Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 104:1342-7. 2007
    ..Evaluation of pulmonary artery endothelial cells from IPAH and control lungs in vitro revealed that oxygen consumption of IPAH cells was ..
  9. ncbi Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    M Sean McMurtry
    Department of Medicine and Pediatrics, University of Alberta, Edmonton, Canada
    Circ Res 95:830-40. 2004
    ..5 in the media. We identify mitochondria-dependent apoptosis as a potential target for therapy and DCA as an effective and selective treatment for PAH...
  10. pmc Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
    M Sean McMurtry
    The Vascular Biology Group and Pulmonary Hypertension Program, University of Alberta, Edmonton, Alberta, Canada
    J Clin Invest 115:1479-91. 2005
    ..Inhibition of the inappropriate expression of survivin that accompanies human and experimental PAH is a novel therapeutic strategy that acts by inducing vascular mitochondria-dependent apoptosis...
  11. pmc Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    Koen Brusselmans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 111:1519-27. 2003
    ....
  12. ncbi Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels
    Evangelos D Michelakis
    Department of Medicine, University of Alberta, Edmonton, Canada
    Circulation 105:244-50. 2002
    ..CH-PHT) is associated with suppressed expression and function of voltage-gated K(+) channels (Kv) in pulmonary artery (PA) smooth muscle cells (SMCs) and a shift in cellular redox balance toward a reduced state...
  13. ncbi Multidetector computed tomography for acute pulmonary embolism
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
    N Engl J Med 354:2317-27. 2006
    ..The accuracy of multidetector computed tomographic angiography (CTA) for the diagnosis of acute pulmonary embolism has not been determined conclusively...
  14. ncbi Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins
    N W Morrell
    Department of Medicine, University of Cambridge, Addenbrooke s and Papworth Hospitals, Cambridge, United Kingdom
    Circulation 104:790-5. 2001
    ..We postulated that pulmonary artery smooth muscle cells (PASMCs) from patients with PPH might demonstrate abnormal growth responses to TGF-beta ..
  15. doi Interleukin-6 overexpression induces pulmonary hypertension
    M Kathryn Steiner
    Division of Pulmonary Critical Care Medicine, University of Massachusetts Memorial Medical Center, Worcester, MA 01655, USA
    Circ Res 104:236-44, 28p following 244. 2009
    Inflammatory cytokine interleukin (IL)-6 is elevated in the serum and lungs of patients with pulmonary artery hypertension (PAH). Several animal models of PAH cite the potential role of inflammatory mediators...
  16. ncbi Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
    R M Tuder
    Department of Pathology, Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Colorado, USA
    J Pathol 195:367-74. 2001
    ..Because markers of angiogenesis are expressed in plexiform lesions in SPH, it is proposed that these lesions may form by a process of disordered angiogenesis...
  17. pmc S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy
    Steven Greenway
    Division of Cardiovascular Research, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 164:253-62. 2004
    ..The relationship of increased S100A4/Mts1 to pathologically similar lesions in the transgenic mice and patients occurs despite differences in localization (endothelial versus smooth muscle cells)...
  18. pmc Pathology of pulmonary hypertension
    Rubin M Tuder
    Division of Cardiopulmonary Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Baltimore, MD 21217, USA
    Clin Chest Med 28:23-42, vii. 2007
    ..This article seeks to show the complementarities of the pathology and pathobiology of PH...
  19. ncbi A USA-based registry for pulmonary arterial hypertension: 1982-2006
    T Thenappan
    Department of Medicine, University of Chicago, IL, USA
    Eur Respir J 30:1103-10. 2007
    ..Inappropriate calcium channel blocker treatment is common. Survival rates have increased but remain low suggesting that prognosis is improving but PAH is still a progressive, fatal disease...
  20. doi Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial
    William T Abraham
    Ohio State University Heart and Vascular Center, Columbus, OH, USA
    Lancet 377:658-66. 2011
    ..Results of previous studies support the hypothesis that implantable haemodynamic monitoring systems might reduce rates of hospitalisation in patients with heart failure. We undertook a single-blind trial to assess this approach...
  21. ncbi Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension
    Xudong Yang
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Circ Res 96:1053-63. 2005
    ..Studies involving normal human pulmonary artery smooth muscle cells (PASMCs) suggest site-specific responses to BMPs...
  22. doi A-lines and B-lines: lung ultrasound as a bedside tool for predicting pulmonary artery occlusion pressure in the critically ill
    Daniel A Lichtenstein
    Daniel A Lichtenstein, Service de Reanimation Medicale, Hopital Ambroise Pare, F 92100 Boulogne, Paris Ouest, France
    Chest 136:1014-20. 2009
    ..The relationship between anterior interstitial edema detected by lung ultrasound and the pulmonary artery occlusion pressure (PAOP) value was investigated.
  23. pmc The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
    Sebastien Bonnet
    Pulmonary Hypertension Program, University of Alberta, Edmonton, AB, Canada IGG 2B7
    Proc Natl Acad Sci U S A 104:11418-23. 2007
    ..increase in intracellular free Ca(2+) ([Ca(2+)](i)) and K(+) ([K(+)](i)) concentrations explains the pulmonary artery smooth muscle cell (PASMC) contraction, proliferation and resistance to apoptosis...
  24. pmc NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3
    Saleh Ismail
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah Health Sciences Centerand VA Medical Center, Salt Lake City, Utah 84132, USA
    Am J Physiol Lung Cell Mol Physiol 296:L489-99. 2009
    ..We previously demonstrated that the NADPH oxidase homolog NOX4 mediates human pulmonary artery smooth muscle cell (HPASMC) proliferation by transforming growth factor-beta1 (TGF-beta1)...
  25. ncbi Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension
    T K Jeffery
    Department of PhysiologyPharmacology, The University of Queensland, St Lucia, Brisbane, Queensland, 4072, Australia
    Pharmacol Ther 92:1-20. 2001
    ..Inhibition of remodelling is generally accompanied by reductions in pulmonary artery pressure. The efficacy of some of the drugs varies, depending on the animal model of the disease...
  26. ncbi Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension
    Mehran Mandegar
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Microvasc Res 68:75-103. 2004
    b>Pulmonary artery vasoconstriction and vascular remodeling greatly contribute to a sustained elevation of pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP) in patients with pulmonary arterial hypertension (PAH)...
  27. ncbi Pathologic assessment of vasculopathies in pulmonary hypertension
    Giuseppe G Pietra
    Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 43:25S-32S. 2004
    ....
  28. pmc Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment
    Danielle L Burke
    Department of Pediatrics and Medicine, University of Colorado Denver, USA
    Am J Physiol Lung Cell Mol Physiol 297:L238-50. 2009
    ....
  29. ncbi Pulmonary artery aneurysms in Behçet syndrome
    Vedat Hamuryudan
    Behçet s Syndrome Research Center, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Am J Med 117:867-70. 2004
  30. ncbi Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells
    Anne Sturrock
    Div of Respiratory, Critical Care and Occupational Pulmonary Medicine, Wintrobe 701, Univ of Utah Medical Center, Salt Lake City, UT 84132, USA
    Am J Physiol Lung Cell Mol Physiol 290:L661-L673. 2006
    ..We studied the consequences of TGF-beta1 stimulation on freshly isolated human pulmonary artery smooth muscle cells (HPASMC)...
  31. pmc Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage
    Maria G Frid
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Pathol 168:659-69. 2006
    ..Vascular remodeling in chronic hypoxic pulmonary hypertension includes marked fibroproliferative changes in the pulmonary artery (PA) adventitia...
  32. pmc Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization
    C Guignabert
    Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford Univ School of Medicine, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1082-90. 2009
    ..Thus the disruption of PPARgamma signaling in EC is sufficient to cause mild PAH and to impair recovery from CH-induced PAH. Inhibition of heightened PDGF-Rbeta signaling is sufficient to reverse PAH in this genetic model...
  33. doi Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats
    Harm J Bogaard
    Division of Pulmonary and Critical Care, Department of Medicine and Victoria Johnson Center for Lung Research, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Respir Crit Care Med 183:1402-10. 2011
    ..Inhibitors of histone deacetylases (HDACs) reduce pressure-overload-induced left ventricular hypertrophy and dysfunction, but their effects on right ventricular (RV) adaptation to pressure overload are unknown...
  34. doi Evaluation of pulmonary artery stiffness in pulmonary hypertension with cardiac magnetic resonance
    Javier Sanz
    Clinical Cardiac MR CT Program, Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 2:286-95. 2009
    This study sought to evaluate indexes of pulmonary artery (PA) stiffness in patients with pulmonary hypertension (PH) using same-day cardiac magnetic resonance (CMR) and right heart catheterization (RHC).
  35. doi Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension
    Amal Houssaini
    INSERM U955 Team 8 and Département de Physiologie, Creteil, France
    Am J Respir Cell Mol Biol 48:568-77. 2013
    b>Pulmonary artery (PA) smooth muscle cell (SMC) proliferation in pulmonary hypertension (PH) may be linked to dysregulated mammalian target of rapamycin (mTOR) signaling...
  36. doi Prognostic relevance of a non-invasive evaluation of right ventricular function and pulmonary artery pressure in patients with chronic heart failure
    Stefano Ghio
    Cardiac, Thoracic and Vascular Department, Fondazione IRCCS Policlinico San Matteo, Piazza Golgi 1, 27100 Pavia, Italy
    Eur J Heart Fail 15:408-14. 2013
    To determine the prognostic relevance of the echocardiographic evaluation of pulmonary artery systolic pressure (PASP) and tricuspid annular plane systolic excursion (TAPSE) in patients with chronic heart failure (CHF)...
  37. ncbi A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter
    C S Ng
    Department of Radiology, Royal Brompton National Heart and Lung Hospital, London, England
    J Thorac Imaging 14:270-8. 1999
    The aim of this study was to determine whether the ratio of the diameters of the main pulmonary artery and of the ascending aorta (rPA), as assessed on computed tomography (CT), is predictive of pulmonary arterial hypertension (PAH)...
  38. pmc Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation
    Qiwei Yang
    Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 303:L1001-10. 2012
    ....
  39. pmc Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells
    Paul D Upton
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge CB2 2QQ, UK
    J Biol Chem 284:15794-804. 2009
    ..the functional roles of these receptors, we examined their relative contributions to BMP signaling in human pulmonary artery endothelial cells (HPAECs)...
  40. doi Reciprocal regulation of HIF-1α and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia
    Lan Yao
    Biopharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150081, PR China
    Prostaglandins Other Lipid Mediat 99:96-106. 2012
    ..Therefore, it is possible that there may be some connections between HIF-1α and 15-LO/15-HETE in hypoxic pulmonary artery smooth muscle cells...
  41. ncbi Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension
    C Tji Joong Gan
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Chest 132:1906-12. 2007
    ..We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated ..
  42. pmc Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8
    Kylie M Drake
    Genomic Medicine Institute, Cleveland Clinic, OH 44195, USA
    Am J Respir Crit Care Med 184:1400-8. 2011
    ..We therefore hypothesized that noncanonical pathways may play an important role in PAH...
  43. ncbi Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension
    Kaori Ihida-Stansbury
    University of Pennsylvania, Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, Philadelphia, PA 19104 6383, USA
    Am J Physiol Lung Cell Mol Physiol 291:L694-702. 2006
    ..BMPR2 mutations express high levels of tenascin-C (TN-C), an extracellular matrix glycoprotein that promotes pulmonary artery (PA) smooth muscle cell (SMC) proliferation...
  44. pmc Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia
    Beata Wojciak-Stothard
    Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, London, UK
    Circ Res 110:1423-34. 2012
    ..RhoB, a protein homologous to RhoA and activated by hypoxia, regulates neoplastic growth and vasoconstriction but its role in the regulation of pulmonary vascular function is not known...
  45. pmc Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
    Peter Dorfmuller
    Universite Paris Sud, Faculte de Medecine, Kremlin Bicetre, F 94276, France
    Respir Res 12:119. 2011
    ..The impact of OS on vascular remodeling in PH is still to be determined. We hypothesized, that augmented blood-flow could increase OS and might thereby contribute to DC/inflammatory cell-recruitment and smooth-muscle-cell-proliferation...
  46. pmc Role of protein transamidation in serotonin-induced proliferation and migration of pulmonary artery smooth muscle cells
    Yinglin Liu
    Rutgers University, Piscataway, New Jersey, USA
    Am J Respir Cell Mol Biol 44:548-55. 2011
    Pulmonary hypertension is characterized by elevated pulmonary artery pressure and pulmonary artery smooth muscle cell (SMC) proliferation and migration...
  47. pmc Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells
    Cong Wang
    Beijing Institute of Respiratory Medicine, Beijing Chao Yang Hospital, Capital Medical University, Beijing, PR China
    Respir Res 10:123. 2009
    ..The mechanism of its anti-proliferative effect on pulmonary artery smooth muscle cells (PASMC) is unclear...
  48. ncbi Extent of MRI delayed enhancement of myocardial mass is related to right ventricular dysfunction in pulmonary artery hypertension
    Gerry P McCann
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    AJR Am J Roentgenol 188:349-55. 2007
    The purpose of our study was to assess the presence and extent of delayed contrast enhancement of ventricular myocardium in pulmonary artery hypertension.
  49. ncbi Primary pulmonary hypertension: a vascular biology and translational research "Work in progress"
    S Archer
    Division of Cardiolgy, Department of Medicine, University of Alberta, WMC 2C2 36, 8440, Edmonton, Alberta, Canada
    Circulation 102:2781-91. 2000
    ..Pharmacological and gene therapies aimed at enhancing the activity of prostacyclin, nitric oxide synthases, and Kv channels or at inhibiting endothelin and matrix metalloproteinases are promising areas for future development...
  50. doi Intramural hematoma of the pulmonary artery and hemopneumomediastinum after endobronchial ultrasound-guided transbronchial needle aspiration
    Maribel Botana-Rial
    Bronchopleural Techniques Unit, Pulmonology Service, Respiratory and Infectious Disease Research Group, Biomedical Research Institute, Complexo Hospitalario Universitario de Vigo, Vigo, Spain
    Respiration 83:353-6. 2012
    ..We describe the first reported case of pulmonary artery intramural hematoma after EBUS-TBNA puncture of this artery...
  51. ncbi Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells
    Paul B Yu
    Cardiovascular Research Center and Anesthesia Center for Critical Care Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 283:3877-88. 2008
    ..b>Pulmonary artery smooth muscle cells lacking BMPRII can transduce BMP signals using ActRIIa (Activin type II receptor)...
  52. pmc Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension
    Grazyna Kwapiszewska
    Department of Pathology, Justus Liebig University Giessen, Germany
    Respir Res 6:109. 2005
    ..For specific investigation of the vascular compartment, laser-microdissection of intrapulmonary arteries was combined with array profiling...
  53. ncbi The 'aortic rim' recount: embolization of interatrial septal occluder into the main pulmonary artery bifurcation after atrial septal defect closure
    Manoranjan Misra
    Department of Cardio Vascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India 695 011
    Interact Cardiovasc Thorac Surg 6:384-6. 2007
    ..We report a rare complication of early embolization of the Blockaid septal occluder into the main pulmonary artery bifurcation associated with 'aortic rim' erosion and present a brief review of literature pertaining to the ..
  54. doi Role of vasodilator-stimulated phosphoprotein in cGMP-mediated protection of human pulmonary artery endothelial barrier function
    Otgonchimeg Rentsendorj
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 294:L686-97. 2008
    ..hypothesis, we examined the role of VASP in the transient barrier dysfunction caused by H(2)O(2) in human pulmonary artery endothelial cell (HPAEC) monolayers studied without and with PKG(I) expression introduced by adenoviral ..
  55. doi Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1-/- mice
    Nikolaos A Maniatis
    Am J Physiol Lung Cell Mol Physiol 294:L865-73. 2008
    ..The elevated basal plasma NO level in Cav1(-/-) mice compensates partly for the vascular structural abnormalities by promoting pulmonary vasodilation...
  56. doi Rosiglitazone attenuates hypoxia-induced pulmonary arterial hypertension in rats
    Eun Kyung Kim
    Department of Pulmonary and Critical Care Medicine, Bundang CHA Hospital, College of Medicine, CHA University, Seongnam, Korea
    Respirology 15:659-68. 2010
    ..We hypothesized that PPARgamma may play a critical role in the development of pulmonary hypertension induced by chronic hypoxia...
  57. ncbi Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferation
    V A Golovina
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Heart Circ Physiol 280:H746-55. 2001
    ..CCE, potentially via hTRP1-encoded Ca(2+)-permeable channels, may be an important mechanism required to maintain the elevated [Ca(2+)](cyt) and stored [Ca(2+)] in human PASMC during proliferation...
  58. pmc Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure
    Jeffrey A Kline
    Department of Emergency Medicine, Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Chest 136:1202-10. 2009
    No published data have systematically documented pulmonary artery pressure over an intermediate time period after submassive pulmonary embolism (PE)...
  59. doi Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo
    Jun Yang
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospital, Cambridge CB20QQ, UK
    Circ Res 107:252-62. 2010
    ..Mutations lead to reduced Smad1/5-driven expression of inhibitor of DNA binding protein 1 (Id1) and loss of the growth suppressive effects of BMPs. The impact of existing PAH therapies on BMP signaling is lacking...
  60. ncbi Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension
    Fares A Masri
    Department of Pathobiology, Allergy and Critical Care Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Physiol Lung Cell Mol Physiol 293:L548-54. 2007
    ..is characterized by plexiform vascular lesions, which are hypothesized to arise from deregulated growth of pulmonary artery endothelial cells (PAEC)...
  61. ncbi Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension
    Hideki Takahashi
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae Machi, Itabashi ku, Tokyo 173 0015, Japan
    Am J Physiol Lung Cell Mol Physiol 290:L450-8. 2006
    ..In rats under normal conditions, BMP-2 is localized in the endothelium of the pulmonary artery, whereas BMPR-II is abundantly expressed in the endothelium, smooth muscle cells, and adventitial fibroblasts...
  62. pmc P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells
    Taras Lyubchenko
    Dept of Pediatrics, University of Colorado Denver, Research 2, Box B131, Aurora, CO 80045, USA
    Am J Physiol Cell Physiol 300:C266-75. 2011
    Extracellular ATP and ADP have been shown to exhibit potent angiogenic effects on pulmonary artery adventitial vasa vasorum endothelial cells (VVEC)...
  63. doi Magnetic resonance-derived 3-dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonary arterial pressure
    Gert Reiter
    Siemens Medical Solutions, Graz, Austria
    Circ Cardiovasc Imaging 1:23-30. 2008
    ..Such pathological altered pressures in the pulmonary vascular system should lead to changes in blood flow patterns in the main pulmonary artery.
  64. ncbi Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling
    Jörg Hänze
    University of Giessen Lung Center UGLC, Medical Clinic II, Biochemistry, Friedrichstr 24, 35392 Giessen, Germany
    Thromb Haemost 97:774-87. 2007
    ..This response results in pulmonary hypertension with right ventricular hypertrophy, a lethal disease. In this review, we summarize and discuss mechanisms by which HIF interferes with the different vascular remodeling processes...
  65. pmc Modern age pathology of pulmonary arterial hypertension
    Elvira Stacher
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Am J Respir Crit Care Med 186:261-72. 2012
    ..The impact of modern treatments of pulmonary arterial hypertension (PAH) on pulmonary vascular pathology remains unknown...
  66. pmc Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation
    Samuel Jalali
    Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, FL, USA
    PLoS ONE 7:e46808. 2012
    ..The effects of miR-206 in modulating cell proliferation, apoptosis and smooth muscle cell markers in human pulmonary artery smooth muscle cells (hPASMCs) were investigated in vitro...
  67. pmc Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
    Tero Pekka Alastalo
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 5162, USA
    J Clin Invest 121:3735-46. 2011
    ..Taken together, our findings suggest that apelin could be effective in treating PAH by rescuing BMPR2 and PAEC dysfunction...
  68. doi Inflammation in pulmonary arterial hypertension
    Laura C Price
    Faculte de Medecine, Universite Paris Sud, Kremlin Bicetre, France
    Chest 141:210-21. 2012
    ..The potential benefit of antiinflammatory therapies in iPAH is of importance and requires further study...
  69. ncbi The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness
    Dante Penaloza
    Department of Medicine, Faculty of Medicine, University Cayetano Heredia, Lima, Peru
    Circulation 115:1132-46. 2007
    ..Chronic mountain sickness is a public health problem in the Andean mountains and other mountainous regions around the world. Therefore, dissemination of preventive and therapeutic measures is essential...
  70. ncbi Operative classification of thromboembolic disease determines outcome after pulmonary endarterectomy
    Patricia A Thistlethwaite
    Divisions of Cardiothoracic Surgery, Biostatistics, and Cardiology, University of California, San Diego, Calif 92103 8892, USA
    J Thorac Cardiovasc Surg 124:1203-11. 2002
    ..We sought to determine whether type and location of thromboembolic disease in the pulmonary vascular tree predicts the hemodynamic result and clinical outcome in patients undergoing pulmonary endarterectomy...
  71. pmc Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells
    Rakesh Rathore
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Free Radic Biol Med 45:1223-31. 2008
    The importance of NADPH oxidase (Nox) in hypoxic responses in hypoxia-sensing cells, including pulmonary artery smooth muscle cells (PASMCs), remains uncertain...
  72. pmc ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif
    Masato Morikawa
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Nucleic Acids Res 39:8712-27. 2011
    ..These results provide insights into the molecular mechanism of BMP signaling and the pathogenesis of vascular lesions of certain genetic disorders, including hereditary hemorrhagic telangiectasia...
  73. pmc NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation
    Sergio de Frutos
    Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Biol Chem 282:15081-9. 2007
    ..These results strongly suggest that NFATc3 plays a role in the chronic hypoxia-induced vascular changes that underlie pulmonary hypertension...
  74. ncbi Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia
    Saadia Eddahibi
    INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
    Circulation 113:1857-64. 2006
    The mechanism of pulmonary artery smooth muscle cell (PA-SMC) hyperplasia in idiopathic pulmonary artery hypertension (iPH) may involve both an inherent characteristic of PA-SMCs and abnormal control by external stimuli...
  75. ncbi Alterations in zinc homeostasis underlie endothelial cell death induced by oxidative stress from acute exposure to hydrogen peroxide
    Dean A Wiseman
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Lung Cell Mol Physiol 292:L165-77. 2007
    ..Previously, we showed that pulmonary artery endothelial cells (PAECs) undergo apoptosis after acute exposure to H(2)O(2)...
  76. pmc Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells
    Sergey Zharikov
    SB Rm M452, Div of Pulmonary, Critical Care, and Sleep Medicine, Dept of Medicine, Univ of Florida, Gainesville, FL 32610, USA
    Am J Physiol Cell Physiol 295:C1183-90. 2008
    ..In isolated porcine pulmonary artery segments (PAS), UA (7.5 mg/dl) inhibits acetylcholine-induced vasodilation...
  77. pmc FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
    Francesca Tonelli
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, UK
    Cell Signal 22:1536-42. 2010
    ..are novel inhibitors of SK1 catalytic activity and induce the proteasomal degradation of this enzyme in human pulmonary artery smooth muscle cells, MCF-7 breast cancer cells and androgen-independent LNCaP-AI prostate cancer cells...
  78. pmc Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites
    Stephen J Wort
    Department of Critical Care, National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom
    J Biol Chem 284:24297-305. 2009
    ..by a combination of tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) in primary human pulmonary artery smooth muscle cells...
  79. pmc Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension
    Patrick Crosswhite
    Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126 0901, USA
    J Hypertens 28:201-12. 2010
    ..arterial hypertension (PAH) is a chronic and progressive disease characterized by a persistent elevation of pulmonary artery pressure accompanied by right ventricular hypertrophy (RVH)...
  80. ncbi Reverse cardiac remodelling in patients with primary pulmonary hypertension after isolated lung transplantation
    Marie Theres Kasimir
    Department of Cardiothoracic and Vascular Anaesthesia and Intensive Care, Medical University of Vienna, Vienna, Austria
    Eur J Cardiothorac Surg 26:776-81. 2004
    ....
  81. pmc Intravascular ultrasound of the elastic pulmonary arteries: a new approach for the evaluation of primary pulmonary hypertension
    J Rodes-Cabau
    Department of Cardiology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Heart 89:311-5. 2003
    ....
  82. ncbi Pulmonary artery rupture induced by a pulmonary artery catheter: a case report and review of the literature
    Alexandre R Abreu
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
    J Intensive Care Med 19:291-6. 2004
    Placement and use of pulmonary artery catheters (PACs) carry potential risks...
  83. pmc Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury
    Sarah A Pendergrass
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS ONE 5:e12106. 2010
    ..The identification and characterization of biomarkers for lSSc-PAH should lead to less invasive screening, a better understanding of pathogenesis, and improved treatment...
  84. ncbi Quantitative models of the rat pulmonary arterial tree morphometry applied to hypoxia-induced arterial remodeling
    Robert C Molthen
    Medical College of Wisconsin, USA
    J Appl Physiol (1985) 97:2372-84; discussion 2354. 2004
    ..015 +/- 0.00077 (SE) mmHg(-1)] (n = 9). The results of the study show that these models can be applied to the Sprague-Dawley rat data and, specifically, can be used to differentiate between the hypoxic and the control groups...
  85. pmc Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1
    Victoria C Foletta
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade Parkville, Victoria 3050, Australia
    J Cell Biol 162:1089-98. 2003
    ..This study identifies the first function of the BMPR-II tail domain and suggests that the deregulation of actin dynamics may contribute to the etiology of PPH...
  86. ncbi Fibrous remodeling of the pulmonary venous system in pulmonary arterial hypertension associated with connective tissue diseases
    Peter Dorfmuller
    Service d Anatomie et de Cytologie Pathologiques, Centre Hospitalier Universitaire Pitie Salpetriere, 47 83, Boulevard de l Hopital, F 75651 Paris Cedex 13, France
    Hum Pathol 38:893-902. 2007
    ....
  87. ncbi Myosin light chain kinase in endothelium: molecular cloning and regulation
    J G Garcia
    Department of Medicine, Indiana University School of Medicine, and Richard Roudebush Veterans Administration Center, Indianapolis, USA
    Am J Respir Cell Mol Biol 16:489-94. 1997
    ..5-fold increase) and reduced kinase activity in MLCK immunoprecipitates (4-fold decrease). These data suggest potentially novel mechanisms of endothelial cell contraction and barrier regulation...
  88. ncbi Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstriction
    S S McDaniel
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, San Diego, California 92103, USA
    Am J Physiol Lung Cell Mol Physiol 280:L870-80. 2001
    Agonist-induced increases in cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) in pulmonary artery (PA) smooth muscle cells (SMCs) consist of a transient Ca(2+) release from intracellular stores followed by a sustained Ca(2+) influx...
  89. ncbi Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
    W Steudel
    Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Circ Res 81:34-41. 1997
    ..Pulmonary hemodynamics were studied by measuring pulmonary artery pressure, left ventricular end-diastolic pressure, and lower thoracic aortic flow by using a novel open-chest ..
  90. ncbi Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy
    Ralph Theo Schermuly
    University of Giessen Lung Centre, Justus Liebig Universitat Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Circulation 115:2331-9. 2007
    ..The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation...
  91. pmc Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents
    Mohamed Izikki
    INSERM U841, Faculte de Medecine, 8 Avenue du General Sarrail, 94010 Creteil, France
    J Clin Invest 119:512-23. 2009
    Pulmonary hypertension (PH) is a progressive, lethal lung disease characterized by pulmonary artery SMC (PA-SMC) hyperplasia leading to right-sided heart failure...
  92. ncbi Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation
    Judd W Landsberg
    Department of Medicine, School of Medicine, University of California, San Diego, California 92103, USA
    News Physiol Sci 19:44-50. 2004
    ..Upregulation of genes encoding these channels is involved in the development of pulmonary hypertension...
  93. ncbi The effects of hypoxia on the cells of the pulmonary vasculature
    O Pak
    Scottish Pulmonary Vascular Unit, Level 8, Western Infirmary, Dumbarton Road, Glasgow, G11 6NT, UK
    Eur Respir J 30:364-72. 2007
    ..It is possible that hypoxia is sensed by fibroblasts, endothelial cells, or both, and relayed to adjacent pulmonary artery smooth muscle cells by intercellular signalling, causing proliferation...
  94. ncbi Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene
    Sami I Said
    Departments of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA
    Circulation 115:1260-8. 2007
    ..We have tested the hypothesis that targeted deletion of the VIP gene may lead to PAH with pulmonary vascular remodeling...
  95. doi Role of G(i/o)-Src kinase-PI3K/Akt pathway and caveolin-1 in β₂-adrenoceptor coupling to endothelial NO synthase in mouse pulmonary artery
    Sébastien Banquet
    INSERM U1045, Centre de recherche cardiothoracique de Bordeaux, Bordeaux, France
    Cell Signal 23:1136-43. 2011
    ..AR) elicits an endothelial nitric oxide synthase (eNOS)-dependent relaxation in mouse pulmonary artery, which, contrary to the muscarinic receptor-dependent relaxation, is preserved in hypoxic pulmonary arterial ..
  96. pmc Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease
    Hibo Noureddine
    INSERM U955, Hopital Henri Mondor, AP HP, Creteil, France
    Circ Res 109:543-53. 2011
    Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by telomere shortening or oxidative stress may contribute to pulmonary hypertension associated with chronic lung diseases.
  97. doi CCN2 promotes cigarette smoke-induced proliferation of rat pulmonary artery smooth muscle cells through upregulating cyclin D1 expression
    Ran Wang
    Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    J Cell Biochem 113:349-59. 2012
    ..by medial thickening of the pulmonary arteries mainly resulting from the abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs). However, the molecular mechanism underlying this process is still unclear...
  98. ncbi Usefulness of magnetic resonance angiography in the evaluation of complex congenital heart disease in newborns and infants
    Ashwin Prakash
    Division of Pediatric Cardiology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Cardiol 100:715-21. 2007
    ..In conclusion, MRA is excellent for the visualization of extracardiac thoracic vessels in young infants with CHD and can be used as an alternative to cardiac catheterization when echocardiography is inconclusive...
  99. doi Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries
    J Milara
    Clinic Research Unit, University General Hospital Consortium, Valencia, Spain
    Eur Respir J 39:927-38. 2012
    ..study examined the effect of cigarette smoke (CS) on ET receptor A (ET(A)) and B (ET(B)) expression in human pulmonary artery smooth muscle cells (HPASMCs) and human small intrapulmonary arteries, as well as their functional ..
  100. doi Pro-apoptotic effects of imatinib on PDGF-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension
    Kazufumi Nakamura
    Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Cardiol 159:100-6. 2012
    Remodeling of the pulmonary artery by an inappropriate increase of pulmonary artery smooth muscle cells (PASMCs) is problematic in the treatment of idiopathic pulmonary arterial hypertension (IPAH)...
  101. pmc The cancer paradigm of severe pulmonary arterial hypertension
    Pradeep R Rai
    Department of Pathology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 178:558-64. 2008
    ..The concept of the endothelial cell as a "quasi-malignant" cell provides a new framework for antiproliferative, antiangiogenic therapy in severe PAH...

Research Grants70

  1. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..provided by applicant): Pulmonary arterial hypertension (PAH) is a fatal disease associated with increased pulmonary artery pressure (PAP) and abnormalities in blood vessel growth...
  2. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..Aim 1 will utilize lung and pulmonary artery tissue and serum procured at the time of organ transplantation in patients with IPAH, disease-specific ..
  3. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..we will breed the RoGFP mice with smooth muscle-specific Cre recombinase mice, to elicit RoGFP expression in pulmonary artery smooth muscle cells in the lung...
  4. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..stimulate the association of eNOS with the mitochondrial outer membrane protein, porin in normal fetal lamb pulmonary artery endothelial cells (PAEC)...
  5. Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary Hypertension
    C Michael Hart; Fiscal Year: 2013
    ..Complementary studies will be performed in vitro in human pulmonary artery endothelial or smooth muscle cells (HPAEC or HPASMC) exposed to hypoxia or in HPAEC or HPASMC isolated from ..
  6. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..This proposal seeks to understand the role of the HIF-1a and mitofusin in PAH and develop therapies (inhibition of HIF-1 a and supplementation of mitofusin-2) to restore mitochondrial form and function and cure PAH. ..
  7. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..The information generated by the proposed experiments will be valuable for the development of new treatments for pulmonary vascular diseases. ..
  8. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    Endothelial dysfunction and platelet aggregation cause pulmonary artery vasoconstriction, mitogenesis, thrombosis, and vascular obliteration in pulmonary arterial hypertension (PAH) The recognition of abnormal eicosanoid metabolism and ..
  9. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2013
    ..and inhibits BMP-mediated activation of vascular smooth muscle cell (VSMC)- specific contractile genes in pulmonary artery smooth muscle cells (PASMCs)...
  10. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..over 12 months on exercise capacity in patients with at least moderate pulmonary hypertension (PH) (mean pulmonary artery pressure [mPAP] >30 mm Hg, pulmonary vascular resistance [PVR]>3...
  11. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..Aim 2 will determine if the combination of asthma plus SCD impairs pulmonary artery vasodilatation, increases pulmonary arterial hypertension (PAH) and increases airway hyperresponsiveness...
  12. Nitric Oxide in Pulmonary Hypertension
    Serpil C Erzurum; Fiscal Year: 2013
    ..provided by applicant): Pulmonary arterial hypertension (PAH) is a fatal disease associated with increased pulmonary artery pressure (PAP) and abnormalities in blood vessel growth...
  13. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..macrophage (AM) which may allow for AM activation of other cells including type 2 pneumocytes (T2P) and pulmonary artery endothelial cells (PAEC)...
  14. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..the discovery that lipopolysaccharide (LPS)/endotoxin binds to and activates A1 adenosine receptors on human pulmonary artery endothelial cells to produce acute lung injury (ALI)...
  15. Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye Dilution
    Istvan Seri; Fiscal Year: 2013
    ..However, placement and maintenance of a pulmonary artery catheter required for such a measurement is technically challenging in neonates and infants and is associated ..
  16. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..Severe pulmonary hypertension (SPH) is an irreversible, malignant elevation of pulmonary artery pressures, often associated with high mortality due to right side heart failure...
  17. Neprilysin and Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
    EDWARD CHARLES DEMPSEY; Fiscal Year: 2013
    ..Proliferation of pulmonary artery (PA) smooth muscle cells (SMCs) at the medial/adventitial border and migration to more distal sites are ..
  18. Interventions Against the Molecular Etiology of BMPR2-induced PAH
    James D West; Fiscal Year: 2013
    ..This study will clarify the early molecular etiology of BMPR2-induced PAH, as well as providing information about BMP regulation of inflammation with implications to a host of diseases. ..
  19. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
    ..The proposed studies will investigate the role of antenatal betamethasone to restore normal vascular function to the infant's lungs before birth to avoid periods of hypoxemia. ..
  20. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2013
    ..that enhances the catalytic activity of endothelial NO synthase (eNOS) and inhibits cGMP-specific PDE5 in pulmonary artery endothelial cells as well as in pulmonary artery smooth muscle cells...
  21. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura V Gonzalez Bosc; Fiscal Year: 2012
    ..A better understanding of this mechanisms in PAH will lead to the development of novel therapeutic approaches to prevent and cure this debilitating disease. ..
  22. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
    ..Recent reports of elevated pulmonary artery pressures in as many as 35% of asymptomatic HIV- positive individuals suggests that HIV-PAH is a more ..
  23. Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)
    Stephen R Wisniewski; Fiscal Year: 2013
    ..the past year tended to have better diffusing capacity for carbon monoxide, less airway obstruction, lower pulmonary artery pressures and cardiac strain, lower peripheral cytokines, and decreased sputum neutrophils despite being ..
  24. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..Ethyl nitrite is an inhaled gas that markedly increases SNO-Hb. Ethyl nitrite decreases severity of pulmonary artery hypertension in adult and infant humans, and selectively decreases end-organ ischemia in models of ..
  25. Novel bundled mechanical and pharmacological CPR platform
    Anja Metzger; Fiscal Year: 2012
    ..return to the heart, increases cardiac output and systemic arterial blood pressure, lowers right atrial and pulmonary artery pressures, lowers intracranial pressure by immediate transference of the negative intrathoracic pressure to ..
  26. Toll-like receptor signaling in pathogenesis of pulmonary hypertension
    Yabing Chen; Fiscal Year: 2013
    ..studies found that hypoxia inhibited the expression of TLR4, and induced the expression of NOX1 and NOX4 in pulmonary artery SMC...
  27. Prostacyclin Synthase and Receptors in Pulmonary Arterial Hypertension
    Mark W Geraci; Fiscal Year: 2011
    Pulmonary Arterial Hypertension (PAH) is characterized by elevations in pulmonary artery pressure, vascular remodeling, and hyperproliferation of endothelial cells...
  28. The role of the Wnt/planar cell polarity pathway in pulmonary angiogenesis
    Vinicio A de Jesus Perez; Fiscal Year: 2013
    ..dealing with the interaction between Wingless (Wnt) and bone morphogenetic protein (BMP) signaling in pulmonary artery endothelial (PAEC) and smooth muscle cells...
  29. Free Hemoglobin Potentiates Pulmonary Vascular Dysfunction in Acute Lung Injury
    JULIE ANNE BASTARACHE; Fiscal Year: 2013
    ..the association between plasma free hemoglobin levels and pulmonary vascular dysfunction (as measured by pulmonary artery pressure, pulmonary vascular resistance, transpulmonary resistance), cardiac dysfunction (as measured by ..
  30. Genetic Analysis of Murine Chronic Hypoxia-Induced Pulmonary Hypertension
    William C Nichols; Fiscal Year: 2013
    ..is known about genes that influence the susceptibility for right ventricular hypertrophy (RVH) and elevated pulmonary artery pressure (PAP)...
  31. Role of Bone Morphogenetic Protein 4 in Hypoxic Pulmomary Hypertension
    Jian Wang; Fiscal Year: 2013
    ..Hypoxia, an important trigger of PH, has been found to enhance calcium signaling in pulmonary artery smooth muscle cells, causing cell proliferation and constriction...
  32. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2012
    ..family of growth factors, TGF2s and BMPs, promote a switch from a "synthetic" to "contractile" phenotype of pulmonary artery smooth muscle cells (PASMCs) by inducing the expression of VSMC-specific genes...
  33. Endothelial Dysfunction and the RV in the Multi-Ethnic Study of Atherosclerosis
    Steven M Kawut; Fiscal Year: 2010
    Pulmonary hypertension is an elevation in pulmonary artery pressure which may result from a variety of heart and lung diseases...
  34. Redox Regulation of Vascular cGMP Signaling in Neonatal Lungs
    Kathryn N Farrow; Fiscal Year: 2013
    ..has previously published that hyperoxia exposure increases both mitochondrial and cytoplasmic ROS in isolated pulmonary artery smooth muscle cells (PASMC)...
  35. DNA LESIONS AND GENE EXPRESSION IN HYPOXIC LUNG DISEASE
    Mark N Gillespie; Fiscal Year: 2013
    ..To test key elements of this hypothesis, we will use pulmonary artery endothelial cells as the model system and manipulate the strand break-forming and break re-ligating steps of ..
  36. Intrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteries
    Sean M Wilson; Fiscal Year: 2013
    ..Such results will provide an important positive impact, because RyRs are highly likely to provide novel targets for therapeutic interventions in the treatment of pulmonary vascular disease. ..
  37. Calpain Activates Intracellular TGF-beta1 in Pulmonary Hypertension
    Yunchao Su; Fiscal Year: 2013
    ..molecule of PDGF, EGF and VEGF, and mediates PDGF- and EGF-induced collagen synthesis and proliferation of pulmonary artery smooth muscle cells (PASMCs) and VEGF-induced angiogenesis of pulmonary artery endothelial cells (PAECs)...
  38. Impact of Insufficient Vascular EC-SOD in Pulmonary Hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2013
    ..We hypothesize that EC-SOD localized to the pulmonary artery (PA) wall is critical to the protection against vascular inflammation and remodeling because it prevents ..
  39. Investigation into Cold-induced Pulmonary Vascular Inflammation and Dysfunction
    Zhongjie Sun; Fiscal Year: 2013
    ..The characteristics of animal CIPH (high pulmonary arterial pressure, pulmonary artery hypertrophy, plexiform lesion) mimic those of human idiopathic PH, making it a relevant and unique model for ..
  40. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2012
    Under conditions of chronic pulmonary artery ischemia, the systemic bronchial circulation undergoes massive proliferation. However, the functional consequences of this rapidly constructed new circulation remain largely unexplored...
  41. PKC Signaling in cAMP-Induced Pulmonary Vasodilation
    SCOTT BARMAN; Fiscal Year: 2010
    ..Progress of these studies will provide important knowledge towards the development of novel therapeutic agents that will help reduce the morbidity and mortality associated with pulmonary hypertension. ..
  42. Properties of Clca Channels in Vascular Myocytes
    Normand Leblanc; Fiscal Year: 2009
    ..the effect of general phosphorylation status on the biophysical properties of Clca channels in rabbit pulmonary artery smooth muscle cells;(2) determine the relative role of CaMKII and serine/threonine phosphatases in the ..
  43. PPAR gamma and Nox4 in pulmonary hypertension
    Roy L Sutliff; Fiscal Year: 2013
    ..In vitro studies will be performed using hypoxia-exposed human pulmonary artery smooth muscle or endothelial cells...
  44. Red Blood Cell S-nitrosothiols and Oxygenation
    Jonathan S Stamler; Fiscal Year: 2012
    ..We have demonstrated that RBCs regulate HPV and thus pulmonary artery pressure, and improve oxygenation, and that these effects are mediated through the pO2- dependent formation ..
  45. ecSOD derived peroxide in pulmonary adaptation to hypoxia
    Michael S Wolin; Fiscal Year: 2013
    ....
  46. Circulating biomarkers of IPAH.
    Allen D Everett; Fiscal Year: 2012
    b>Pulmonary artery hypertension in children or adults (PAH) is a progressive and fatal disease characterized by sustained elevations of pulmonary artery pressure of unknown etiology. Vasodilators are the mainstay of therapy...
  47. MicroRNAs regulate proliferative signaling pathways in pulmonary hypertension
    DAVID EMERSON GREEN; Fiscal Year: 2013
    ..Following exposure to hypoxic conditions that stimulate human pulmonary artery smooth muscle cell (HPASMC) proliferation, qRT-PCR will be employed to determine miRNA-21 levels...
  48. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI MICHELLE PORTER; Fiscal Year: 2010
    ..by applicant): We have found that HIV-1 transgenic rats and HIV-1-treated co-cultures containing human pulmonary artery endothelial cells (HPAEC) and peripheral blood mononuclear cells (PBMC) demonstrate striking increases in ..
  49. Mechanisms of Vascular Neotissue Formation In Tissue Engineered Vascular Grafts
    CHRISTOPHER KANE BREUER; Fiscal Year: 2013
    ..the first clinical trial evaluating the use of our TEVG as a conduit connecting the inferior vena cava to the pulmonary artery in children requiring modified Fontan surgery...
  50. Muscularization of pulmonary arteries induced by an adaptive immune response
    Gabriele Grunig; Fiscal Year: 2010
    ..The proposed studies are aimed at delineating the cellular origin and mediators that cause the accumulation of these smooth muscle cells in a mouse model of severe pulmonary arterial remodeling induced by the adaptive immune response. ..
  51. Mechanobiology of Vascular Remodeling in Pulmonary Arterial Hypertension
    LAURA ELIZABETH FREDENBURGH; Fiscal Year: 2013
    ..hypertension (PAH) is a severe disease characterized by excessive proliferation of apoptosis-resistant pulmonary artery endothelial cells (PAEC) and smooth muscle cells (PASMC), progressive pulmonary arterial (PA) stiffening, and ..
  52. Morphogenesis of the pulmonary artery smooth muscle layer
    Daniel Greif; Fiscal Year: 2012
    ..and cellular events encompassing the morphogenesis of the smooth muscle cell (SMC) layer of the left pulmonary artery during the initial four days of murine lung development...
  53. HIMF/FIZZ1/RELM-alpha activates macrophages in pulmonary hypertension
    Lucas Meuchel; Fiscal Year: 2013
    ..by contraction and significant remodeling of the small pulmonary vessels, resulting in increased pulmonary artery pressure, right heart failure, and death...
  54. Smooth Muscle Cell Protein Serotonylation and Pulmonary Hypertension
    BARRY FANBURG; Fiscal Year: 2013
    ..We believe we have discovered a novel explanation for the mechanism by which serotonin (5- HT) produces pulmonary artery smooth muscle cell (SMC) proliferation and migration...
  55. Directed Self Assembly of Complex Branching Micro-Tissues
    JEFFREY R contact MORGAN; Fiscal Year: 2010
    ..cells (SMC) and two endothelial cell lines;human umbilical cord vein endothelial cells (HUVEC) and calf pulmonary artery endothelial cells (CPAE) to test the following specific aims: Aim 1...
  56. BH4 in hyperoxic lung injury in newborn
    Ru Jeng Teng; Fiscal Year: 2013
    ..Decreased NO formation can increase pulmonary artery vasomotor tone and aggravate respiratory distress in premature infants...
  57. Effect of Spironolactone of Collagen Synthesis in Pulmonary Arterial Hypertension
    Zeenat Safdar; Fiscal Year: 2013
    ..Biosynthesis of aldosterone was documented in human pulmonary artery endothelial cells...
  58. Role of the PDGF signaling pathway in pulmonary artery hypertension
    Akiko Hata; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pulmonary artery hypertension (PAH) is a disease characterized by increased pulmonary artery (PA) resistance associated with pulmonary vascular remodeling, including proliferation of pulmonary artery ..
  59. Role of 15-lipoxygenase in Enhanced Pulmonary Vasoconstriction in Females
    Sandra L Pfister; Fiscal Year: 2010
    ..by applicant): Pulmonary arterial hypertension encompasses a group of diseases characterized by high pulmonary artery pressure and pulmonary vascular resistance...
  60. AccuTemp Sensor: Radiometry based non-invasive continuous core body temperature m
    DOUGLAS O REUDINK; Fiscal Year: 2013
    ..The most accurate predictions of brain temperature today uses intravascular sensors in the pulmonary artery or jugular vein, but these are inconvenient and potentially harmful...
  61. Vevo 2100 Imaging System - High Resolution Ultrasound for Biomicroscopy
    R John Solaro; Fiscal Year: 2013
    ..are (1) the ability to perform blood flow quantification in muscle and tumors, and measure aortic and pulmonary artery regurgitation in hypertrophic and maladaptive hearts, (2) acquire data at higher frame rates and higher ..
  62. Peri-arteriolar Myofibroblast Differentiation in the Pathobiology of IPAH
    ARTHUR ROGER STRAUCH; Fiscal Year: 2012
    ..syndromes using epigenetic/metabolic approaches that target SRF-Pur [unreadable] physical interplay in pulmonary artery adventitial fibroblasts isolated from normal or disease-affected donors...
  63. T helper 2 Inflammation &Severe Muscularization of Arteries in the Lungs.
    Gabriele Grunig; Fiscal Year: 2013
    ..is commonly seen in infections with helminth parasites that spend part of their life cycle in the pulmonary artery (e.g. Dirofilaria immitis). These parasites induce a T helper 2 (Th2) response...
  64. INHIBITORY LEFT ATRIAL INFLUENCES ON THE BAROREFLEX
    David Ramsay; Fiscal Year: 1991
    ..be achieved by graded constriction of cuffs placed around the thoracic portion of the inferior vena cava, pulmonary artery, ascending aorta and abdominal aorta proximal to the renal arteries...
  65. PATHOPHYSIOLOGY OF ISCHEMIA-REPERFUSION LUNG INJURY
    AUBREY TAYLOR; Fiscal Year: 1992
    ..By correlating the pathophysiological changes in vascular permeability and resistances with biochemical and histologic findings, a better understanding of the mechanisms of lung injury following ischemia-reperfusion will be obtained...
  66. PERINATAL PULMONARY CIRCULATION--VASOACTIVE MEDIATORS
    Michael Heymann; Fiscal Year: 1999
    ....
  67. ENDOTHELIAL CELL DIVERSITY DURING FETAL DEVELOPMENT
    Eugene Levin; Fiscal Year: 2001
    ..This will not only serve to broaden our understanding of the molecular basis of endothelial phenotype variation but will also serve as a model for other developing systems. ..
  68. A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2007
    ..Moreover, LPS binds to and activates A1 ARs on human pulmonary artery endothelial cells to induce the release of substances which are cytotoxic to endothelial cells thereby ..
  69. Novel Treatment for Septicemia Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2004
    ..on the discovery and recent report that endotoxin binds to and activates A1 adenosine receptors (AR) on human pulmonary artery endothelial cells. Previously, it was reported that A1 AR antagonists block endotoxin-induced ALl...
  70. Bronchial Angiogenesis in the Ischemic Lung
    Adlah Sukkar; Fiscal Year: 2007
    ..Our laboratory has studied systemic angiogenesis in mice after chronic left pulmonary artery ligation (LPAL) where inflammatory cytokines, predominantly ELR+ CXC chemokines, appear to play a role in ..