femoral artery

Summary

Summary: The main artery of the thigh, a continuation of the external iliac artery.

Top Publications

  1. ncbi Radial versus femoral access for coronary angiography or intervention and the impact on major bleeding and ischemic events: a systematic review and meta-analysis of randomized trials
    Sanjit S Jolly
    Department of Medicine, Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
    Am Heart J 157:132-40. 2009
  2. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
  3. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
  4. pmc Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis
    Sarah L Tressel
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 28:1989-95. 2008
  5. ncbi Natural killer cells and CD4+ T-cells modulate collateral artery development
    V van Weel
    Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2310-8. 2007
  6. ncbi Type 2 diabetes is associated with increased pulse wave velocity measured at different sites of the arterial system but not augmentation index in a Chinese population
    Minghua Zhang
    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
    Clin Cardiol 34:622-7. 2011
  7. ncbi Impact of bed rest on conduit artery remodeling: effect of exercise countermeasures
    Noortje T L van Duijnhoven
    Department of Physiology, Geert Grooteplein Noord 21, 6525 EZ Nijmegen, The Netherlands
    Hypertension 56:240-6. 2010
  8. ncbi Early adverse effect of abnormal glucose metabolism on arterial stiffness in drug naive hypertensive patients
    Gregory Vyssoulis
    Hypertension and Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece
    Diab Vasc Dis Res 9:18-24. 2012
  9. pmc Cellular and molecular mechanism regulating blood flow recovery in acute versus gradual femoral artery occlusion are distinct in the mouse
    Yagai Yang
    Department of Medicine, Division of Cardiology, University of California, San Francisco, California, USA
    J Vasc Surg 48:1546-58. 2008
  10. ncbi Transapical versus transfemoral aortic valve implantation: a comparison of survival and safety
    Malin Johansson
    Department of Cardiothoracic Surgery, Cardiothoracic Anesthesia and Intensive Care, Skåne University Hospital and Lund University, Lund, Sweden
    Ann Thorac Surg 91:57-63. 2011

Detail Information

Publications291 found, 100 shown here

  1. ncbi Radial versus femoral access for coronary angiography or intervention and the impact on major bleeding and ischemic events: a systematic review and meta-analysis of randomized trials
    Sanjit S Jolly
    Department of Medicine, Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
    Am Heart J 157:132-40. 2009
    ..The objective of this meta-analysis was to determine if radial access reduces major bleeding and as a result can reduce death and ischemic events compared to femoral access...
  2. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
    ..This study provides the first direct evidence in a longitudinal study that aortic stiffness is an independent predictor of primary coronary events in patients with essential hypertension...
  3. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
    ..Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages...
  4. pmc Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis
    Sarah L Tressel
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 28:1989-95. 2008
    ..We hypothesized that Ang2 plays an important role in blood flow recovery after arterial occlusion in vivo by regulating angiogenesis and arteriogenesis...
  5. ncbi Natural killer cells and CD4+ T-cells modulate collateral artery development
    V van Weel
    Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2310-8. 2007
    ..Here, we studied the role of lymphocytes in a murine model of hindlimb ischemia...
  6. ncbi Type 2 diabetes is associated with increased pulse wave velocity measured at different sites of the arterial system but not augmentation index in a Chinese population
    Minghua Zhang
    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
    Clin Cardiol 34:622-7. 2011
    ..Moreover, the association between pulse wave velocity (PWV) and augmentation index (AIx) in diabetes is poorly understood...
  7. ncbi Impact of bed rest on conduit artery remodeling: effect of exercise countermeasures
    Noortje T L van Duijnhoven
    Department of Physiology, Geert Grooteplein Noord 21, 6525 EZ Nijmegen, The Netherlands
    Hypertension 56:240-6. 2010
    ..the impact of 60 days of bed rest, with or without exercise countermeasures, on carotid and superficial femoral artery wall thickness...
  8. ncbi Early adverse effect of abnormal glucose metabolism on arterial stiffness in drug naive hypertensive patients
    Gregory Vyssoulis
    Hypertension and Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece
    Diab Vasc Dis Res 9:18-24. 2012
    ..Given the prognostic significance of arterial stiffness, aims should be towards closer monitoring and intensive care of hypertensive patients with abnormal glucose metabolism...
  9. pmc Cellular and molecular mechanism regulating blood flow recovery in acute versus gradual femoral artery occlusion are distinct in the mouse
    Yagai Yang
    Department of Medicine, Division of Cardiology, University of California, San Francisco, California, USA
    J Vasc Surg 48:1546-58. 2008
    ..We, therefore, developed the first mouse model of gradual arterial occlusion and tested the hypothesis that the mechanisms regulating blood flow recovery are critically dependent on the rate of arterial occlusion...
  10. ncbi Transapical versus transfemoral aortic valve implantation: a comparison of survival and safety
    Malin Johansson
    Department of Cardiothoracic Surgery, Cardiothoracic Anesthesia and Intensive Care, Skåne University Hospital and Lund University, Lund, Sweden
    Ann Thorac Surg 91:57-63. 2011
    ..We aimed to evaluate access-related complications between the transfemoral (TF) and the transapical (TA) approach and to compare survival between TAVI and conventional AVR in propensity-score-matched patients...
  11. ncbi Dynamic contrast-enhanced MRI of muscle perfusion combined with MR angiography of collateral artery growth in a femoral artery ligation model
    Quido G de Lussanet
    Department of Radiology, Maastricht University Hospital, Maastricht, The Netherlands
    NMR Biomed 20:717-25. 2007
    ..and MRA) protocol was performed serially in 15 male rabbits at 2 h (day 0(+)), 7 days, and 21 days after femoral artery ligation...
  12. ncbi A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI)
    Kohji Shirai
    Internal Medicine, Sakura Hospital, Medical Center, Toho University, 564 1 Shimoshizu, Sakura shi, Chiba 285 8741, Japan
    J Atheroscler Thromb 13:101-7. 2006
    To measure the stiffness of the aorta, femoral artery and tibial artery noninvasively, cardio-ankle vascular index (CAVI) which is independent of blood pressure was developed...
  13. ncbi Radial versus femoral approach for percutaneous coronary diagnostic and interventional procedures; Systematic overview and meta-analysis of randomized trials
    Pierfrancesco Agostoni
    Department of Biomedical and Surgical Sciences, Section of Cardiology, University of Verona, Verona, Italy
    J Am Coll Cardiol 44:349-56. 2004
    ..We sought to compare, through a meta-analytic process, the transradial and transfemoral approaches for coronary procedures in terms of clinical and procedural outcomes...
  14. ncbi Complications of femoral artery closure devices
    D Carey
    Stroobants Heart Center, Lynchburg General Hospital, Lynchburg, Virginia 24501, USA
    Catheter Cardiovasc Interv 52:3-7; discussion 8. 2001
    We have examined our prospectively collected experience with femoral artery closure devices...
  15. ncbi Predictors of complications and learning curve using the Angio-Seal closure device following interventional and diagnostic catheterization
    B S Warren
    Department of Chemistry, Carleton College, Northfield, Minnesota, USA
    Catheter Cardiovasc Interv 48:162-6. 1999
    ..Complications included vascular surgery for collagen plug perforation into the femoral artery (0.8%), failure to deploy (5.6%), pseudoaneurysm (0...
  16. ncbi Safety and efficacy of the subclavian approach for transcatheter aortic valve implantation with the CoreValve revalving system
    Anna Sonia Petronio
    Cardiothoracic Department, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
    Circ Cardiovasc Interv 3:359-66. 2010
    ..The standard retrograde approach through the femoral artery is contraindicated in case of unfavorable iliofemoral anatomy or extensive disease...
  17. ncbi Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial
    Sanjit S Jolly
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 377:1409-20. 2011
    ..We aimed to assess whether radial access was superior to femoral access in patients with acute coronary syndromes (ACS) who were undergoing coronary angiography with possible intervention...
  18. ncbi Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion
    W D Ito
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Circ Res 80:829-37. 1997
    ..In order to investigate whether MCP-1 enhances collateral growth after femoral artery occlusion, 12 rabbits were randomly assigned to receive either MCP-1, PBS, or no local infusion via osmotic ..
  19. pmc Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis
    Xuming Dai
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Rd, CB 7545, Chapel Hill, NC 27599, USA
    Circ Res 106:1870-81. 2010
    ..The collateral circulation is tissue- and life-saving in obstructive arterial disease. Disappointing outcomes in clinical trials aimed at augmenting collateral growth highlight the need for greater understanding of collateral biology...
  20. ncbi Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation
    Jiayi Cheng
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Life Sci 72:2263-71. 2003
    ..We measured thrombotic occlusion time in a mouse femoral artery thrombosis model by the photochemical reaction between intravenously injected rose bengal and green light ..
  21. pmc Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats
    Xiao Lu
    Department of Biomedical Engineering, Cellular and Integrative Physiology, Surgery, and Indiana Center for Vascular Biology and Medicine, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Cardiovasc Diabetol 10:48. 2011
    ..We investigated whether inhibition of protein kinase C (PKC) would affect vascular function in diabetic hypertensive (DH) rats...
  22. ncbi Evaluation of left ventricular function in anesthetized patients using femoral artery dP/dt(max)
    Stefan G De Hert
    Department of Anesthesiology, University Hospital Antwerp, Edegem, Belgium
    J Cardiothorac Vasc Anesth 20:325-30. 2006
    The purpose of this study was to compare dP/dt(max) estimated from a femoral artery pressure tracing to left ventricular (LV) dP/dt(max) during various alterations in myocardial loading and contractile function.
  23. ncbi Combination of amlodipine and atorvastatin synergistically reduces leukocyte recruitment to mechanically injured mouse femoral artery
    Sumihiko Hagita
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertens Res 34:450-5. 2011
    ..The intraluminal wire injury of the mouse femoral artery induced significant leukocyte recruitment to the injured area and oxidative stress within 24 h...
  24. pmc Consistency of aortic distensibility and pulse wave velocity estimates with respect to the Bramwell-Hill theoretical model: a cardiovascular magnetic resonance study
    Anas Dogui
    INSERM U678, Paris, France
    J Cardiovasc Magn Reson 13:11. 2011
    ..This study aimed at evaluating the consistency of the automated estimation of regional and local aortic stiffness indices from cardiovascular magnetic resonance (CMR) data...
  25. ncbi Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women
    Kerrie L Moreau
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, Colorado, USA
    Eur J Cardiovasc Prev Rehabil 13:805-11. 2006
    b>Femoral artery intima-media thickness (IMT), an independent predictor of atherosclerotic disease risk, increases with age in sedentary adults. It is not known whether regular aerobic exercise modulates femoral IMT with ageing.
  26. ncbi Balloon angioplasty versus stenting with nitinol stents in intermediate length superficial femoral artery lesions
    Petra Dick
    Department of Angiology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria, Europe
    Catheter Cardiovasc Interv 74:1090-5. 2009
    ..trials investigating stent implantation compared with balloon angioplasty for treatment of superficial femoral artery (SFA) disease have given divergent results in short (mean 5 cm) and intermediate (mean 10 cm) lesions...
  27. pmc Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Cardiovasc Magn Reson 13:66. 2011
    ..Here we demonstrate the feasibility of a simultaneous measurement of blood flow and HbO2 in the femoral circulation as part of a single procedure...
  28. ncbi Skeletal muscle degeneration and regeneration after femoral artery ligation in mice: monitoring with diffusion MR imaging
    Anneriet M Heemskerk
    Biomedical NMR Group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Radiology 243:413-21. 2007
    To prospectively evaluate quantitative diffusion magnetic resonance (MR) imaging for monitoring skeletal muscle injury and repair after femoral artery ligation in mice.
  29. ncbi Hemodynamic relationships among upper-abdominal aorta and femoral arteries: basis for measurement of arterial blood flow to abdominal-pelvic organs
    Takuya Osada
    Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo, Japan
    Med Sci Monit 15:CR332-40. 2009
    ..The aim was to examine 1) basal hemodynamic parameters such as vessel diameter (VD), blood velocity (BV), and BF and their relationship to Ao and FAs and 2) how both BFAo and BFFAs influence the magnitude of BFAP...
  30. ncbi Impact of diabetes mellitus on outcomes of superficial femoral artery endoluminal interventions
    Andrew M Bakken
    Center for Vascular Disease, Division of Vascular Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Vasc Surg 46:946-958; discussion 958. 2007
    Although aggressive endoluminal therapy for superficial femoral artery (SFA) occlusive disease is commonplace, the implications of diabetes mellitus (DM) on long-term outcomes in this population are unclear...
  31. pmc Blood flow interplays with elastin: collagen and MMP: TIMP ratios to maintain healthy vascular structure and function
    Poulami Basu
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Vasc Health Risk Manag 6:215-28. 2010
    ..To test this hypothesis, in vivo blood flow and blood pressure in the aorta, carotid, femoral artery, and femoral vein was measured in male Sprague-Dawley rats (weight 380-400 gm)...
  32. ncbi Impact of wall thickness on conduit artery function in humans: is there a "Folkow" effect?
    Dick H J Thijssen
    Research Institute for Sport and Exercise Science, Liverpool John Moore s University, Liverpool L3 2ET, United Kingdom
    Atherosclerosis 217:415-9. 2011
    ....
  33. ncbi Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age
    S Meaume
    Geriatrics Department of Charles-Foix Hospital, Limeil-Brevannes, France
    Arterioscler Thromb Vasc Biol 21:2046-50. 2001
    ..In subjects 70 to 100 years old, aortic PWV is a strong, independent predictor of cardiovascular death, whereas systolic or pulse pressure was not. This prospective result will need to be confirmed in an intervention trial...
  34. ncbi Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery
    Hok Sum Leung
    Li Ka Shing Institute of Health Sciences and Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Vascul Pharmacol 44:299-308. 2006
    ..factor (EDHF, sensitive to charybdotoxin plus apamin, ouabain, and BaCl2), the endothelium of rat femoral artery can release H2O2 in response to acetylcholine, which was sensitive to L-NAME...
  35. pmc Tempol attenuates the exercise pressor reflex independently of neutralizing reactive oxygen species in femoral artery ligated rats
    Jennifer L McCord
    Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Appl Physiol (1985) 111:971-9. 2011
    In decerebrate rats, we reported previously that the exercise pressor reflex arising from a limb whose femoral artery was occluded for 72 h before the experiment was significantly higher than the exercise pressor reflex arising from a ..
  36. ncbi Effect of vascular risk factors on increase in carotid and femoral intima-media thickness. Identification of a risk scale
    A Berni
    Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy
    Atherosclerosis 216:109-14. 2011
    ....
  37. ncbi Weight change is associated with change in arterial stiffness among healthy young adults
    Rachel P Wildman
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
    Hypertension 45:187-92. 2005
    ..These data greatly underscore the vascular benefit of weight loss. Successful weight loss programs in young adults, particularly blacks, are needed...
  38. ncbi Mechanisms of the dilator action of Danshen (Salvia miltiorrhiza) on rat isolated femoral artery
    Francis Fu Yuen Lam
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    J Cardiovasc Pharmacol 46:361-8. 2005
    This study investigates the actions of Danshen crude extract (Salvia miltiorrhiza) on rat isolated femoral artery rings precontracted with phenylephrine...
  39. pmc Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats
    Y Shi
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Br J Pharmacol 154:639-51. 2008
    ..To investigate the dysfunction of vascular smooth muscle in streptozotocin-induced diabetic rats...
  40. ncbi Development of animal model for vasculatic neuropathy: Induction by ischemic-reperfusion in the rat femoral artery
    Arunachalam Muthuraman
    Rayat Institute of Pharmacy, Ropar Campus, Nawanshahr District, Railmajra, Near Ropar 144533, Punjab, India
    J Neurosci Methods 186:215-21. 2010
    ..This model can be used to explore pathophysiological mechanisms implied in the genesis of neuropathic pain and also to evaluate the new analgesic agents, peripheral neuro-vasoactive substances and neuroprotective drugs...
  41. ncbi Hypoxia sensing in the fetal chicken femoral artery is mediated by the mitochondrial electron transport chain
    Bea Zoer
    University Hospital Maastricht, P Debyelaan 25, AZ Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 298:R1026-34. 2010
    ..In conclusion, our experiments suggest that the mETC plays a critical role in O(2) sensing in fetal chicken femoral arteries. In contrast, hypoxia-induced relaxation appears not to be mediated by ROS or K(+) channels...
  42. ncbi Heparin-bonded expanded polytetrafluoroethylene vascular graft for femoropopliteal and femorocrural bypass grafting: 1-year results
    Marc Bosiers
    Department of Vascular Surgery, St Blasius Hospital, Dendermonde, Belgium
    J Vasc Surg 43:313-8; discussion 318-9. 2006
    ..This study assessed the performance of a new heparin-bonded ePTFE vascular graft that was designed to provide resistance to thrombosis and thereby decrease early graft failures and possibly prolong patency...
  43. ncbi Validation of a new non-invasive portable tonometer for determining arterial pressure wave and pulse wave velocity: the PulsePen device
    Paolo Salvi
    Department of Internal Medicine, Bufalini Hospital, Cesena, Italy
    J Hypertens 22:2285-93. 2004
    ..Its software provides absolute arterial pressure values, an assessment of arterial pulse wave contours, an estimation of reflection waves and measurements of PWV...
  44. pmc Single limb exercise induces femoral artery remodeling and improves blood flow in the hemiparetic leg poststroke
    Sandra A Billinger
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Stroke 40:3086-90. 2009
    ..The purpose of this study was to determine the effect of single limb exercise (SLE) on femoral artery blood flow, diameter, and peak flow velocity in the hemiparetic leg after stroke.
  45. pmc Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
    Xiao Lu
    Department of Biomedical Engineering, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Cardiovasc Diabetol 9:19. 2010
    ..The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling...
  46. ncbi Saphenous vein loop to femoral artery arteriovenous fistula: a practical alternative
    Daphne Pierre-Paul
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Ann Vasc Surg 18:223-7. 2004
    ..The authors' experience with the greater saphenous vein to common femoral artery loop arteriovenous fistula (GSV-CFA AVF) is presented...
  47. ncbi A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia
    M Sata
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, 113 8655, Japan
    J Mol Cell Cardiol 32:2097-104. 2000
    ..A straight spring wire was inserted into the femoral artery via arterioctomy in a small muscular branch...
  48. ncbi Ultrastructure and molecular histology of rabbit hind-limb collateral artery growth (arteriogenesis)
    D Scholz
    Department of Experimental Cardiology, Max Planck Institute, Bad Nauheim, Germany
    Virchows Arch 436:257-70. 2000
    ..the ultrastructure and molecular histology of growing and remodeling collateral arteries that develop after femoral artery occlusion in rabbits as a function of time from 2 h to 240 days after occlusion...
  49. ncbi Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness
    Hirofumi Tanaka
    Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX 78712, USA
    J Hypertens 27:2022-7. 2009
    ..Carotid-femoral pulse wave velocity (cfPWV) is the most recognized and established index of arterial stiffness. An emerging automatic measure of PWV primarily used in the Asian countries is brachial-ankle PWV (baPWV)...
  50. ncbi Neutralizing antibody against interleukin-6 attenuates posthemorrhagic vasospasm in the rat femoral artery model
    George Bowman
    Division of Neurosurgery, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Neurosurgery 54:719-25; discussion 725-6. 2004
    ..In the present study, we investigated the relationship between various inflammatory cytokines (tumor necrosis factor-alpha, interleukin [IL]-1alpha, IL-1beta, and IL-6) and the development of experimental vasospasm...
  51. ncbi The range of adaptation by collateral vessels after femoral artery occlusion
    Inka Eitenmüller
    Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Circ Res 99:656-62. 2006
    Natural adaptation to femoral artery occlusion in animals by collateral artery growth restores only approximately 35% of adenosine-recruitable maximal conductance (C(max)) probably because initially elevated fluid shear stress (FSS) ..
  52. ncbi Survival after transapical and transfemoral aortic valve implantation: talking about two different patient populations
    Sabine Bleiziffer
    Clinic for Cardiovascular Surgery, German Heart Center Munich, Lazarettstrasse 36, Munich, Germany
    J Thorac Cardiovasc Surg 138:1073-80. 2009
    ..We analyzed survival in patients undergoing transcatheter aortic valve implantation with special emphasis on the access site for implantation...
  53. ncbi Detection of peripheral vascular stenosis by assessing skeletal muscle flow reserve
    Thanjuvar Bragadeesh
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia
    J Am Coll Cardiol 45:780-5. 2005
    ..We sought to determine whether the severity of peripheral arterial disease (PAD) can be assessed by measuring blood flow reserve in limb skeletal muscle with contrast-enhanced ultrasound (CEU)...
  54. ncbi A causal role for endothelin-1 in the vascular adaptation to skeletal muscle deconditioning in spinal cord injury
    Dick H J Thijssen
    Department of Physiology, Institute of Fundamental and Clinical Movement Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein Noord 21, 6525 EZ, Nijmegen, The Netherlands
    Arterioscler Thromb Vasc Biol 27:325-31. 2007
    ..In this study, we assess the contribution of ET-1 to the increased vascular tone in the extremely deconditioned legs of spinal cord-injured (SCI) individuals before and after exercise training...
  55. ncbi A new rat model of diabetic macrovascular complication
    Celine Bouvet
    University of Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 73:504-11. 2007
    ..The aim was to devise a rat model of elastocalcinosis in association with diabetes to examine the hypothesis that diabetes accelerates vascular calcification experimentally...
  56. ncbi Claudication secondary to Perclose use after percutaneous procedures
    James J Jang
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York 10029, USA
    Catheter Cardiovasc Interv 67:687-95. 2006
    ..Once diagnosis was correctly made, the patients either underwent surgical repair or percutaneous balloon angioplasty and in all cases the symptoms abated...
  57. ncbi Inhibition of 5-hydroxytryptamine receptor prevents occlusive thrombus formation on neointima of the rabbit femoral artery
    K Nishihira
    Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    J Thromb Haemost 4:247-55. 2006
    ..However, the roles of 5-HT2A receptor in occlusive thrombus formation on disrupted plaque remain obscure...
  58. pmc Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: role of adipo-vascular axis in chronic inflammation
    Sumihiko Hagita
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    PLoS ONE 6:e19871. 2011
    ..In the present study, we examined the direct effects of adipose tissue on macro-vascular inflammation using intravital microscopic analysis of the femoral artery after adipose tissue transplantation.
  59. pmc Evaluation of cuff-induced ischemia in the lower extremity by magnetic resonance oximetry
    Michael C Langham
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 55:598-606. 2010
    ....
  60. ncbi Variations in surgical procedures for hind limb ischaemia mouse models result in differences in collateral formation
    A A Hellingman
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Vasc Endovasc Surg 40:796-803. 2010
    ..To identify the optimal mouse model for hind limb ischaemia, which offers a therapeutic window that is large enough to detect improvements of blood flow recovery, for example, using cell therapies...
  61. ncbi Subintimal recanalization of long superficial femoral artery occlusions through the retrograde popliteal approach
    S Yilmaz
    Department of Radiology, Akdeniz University School of Medicine, Arapsuyu 07070, Antalya, Turkey
    Cardiovasc Intervent Radiol 24:154-60. 2001
    To investigate the value of the retrograde popliteal artery approach for the percutaneous intentional extraluminal recanalization (PIER) of long superficial femoral artery (SFA) occlusions.
  62. ncbi Comparison of ascending aorta versus femoral artery cannulation for acute aortic dissection type A
    Hiroyuki Kamiya
    Department of Cardiac Surgery, University Hospital Heidelberg, Germany
    Circulation 120:S282-6. 2009
    ..The site of cannulation for repair of ascending aortic dissection remains controversial. We present our experience with ascending aortic cannulation for acute aortic dissection type A...
  63. ncbi Totally videoendoscopic descending thoracic aorta-to-femoral artery bypass
    Sumio Fukui
    Department of Vascular Surgery, Clinique Alleray Labrouste, Paris, France
    J Vasc Surg 51:1560-3. 2010
    Descending thoracic aorta to femoral artery bypass is an effective and safe procedure for the treatment of aortoiliac occlusive disease when an approach to the abdominal aorta is undesirable...
  64. ncbi Paclitaxel-eluting stents show superiority to balloon angioplasty and bare metal stents in femoropopliteal disease: twelve-month Zilver PTX randomized study results
    Michael D Dake
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center, 300 Pasteur Drive, Stanford, CA 94305 5407, USA
    Circ Cardiovasc Interv 4:495-504. 2011
    ....
  65. ncbi Heparin-bonded ePTFE grafts compared with vein grafts in femoropopliteal and femorocrural bypasses: 1- and 2-year results
    Kim Daenens
    Department of Vascular Surgery, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium
    J Vasc Surg 49:1210-6. 2009
    ..This nonrandomized study compared the performance of these grafts with that of ASV conduits in the largest clinical series of heparin-bonded ePTFE graft implantations reported so far...
  66. ncbi Tuberculous pseudoaneurysm of the femoral artery complicated by cutaneous tuberculosis of the foot: a case report
    Kathryn Leccese
    Department of Surgery, Division of Vascular Surgery, Hopital Maisonneuve Rosemont
    J Vasc Surg 44:654-7. 2006
    An infected pseudoaneurysm of the right common femoral artery in a 69-year-old patient receiving methotrexate therapy was confirmed to have been caused by Mycobacterium tuberculosis...
  67. ncbi Deep hypothermic circulatory arrest and the femoral-to-radial arterial pressure gradient
    Gerard R Manecke
    Department of Anesthesiology, UCSD Medical Center, San Diego, CA 92103
    J Cardiothorac Vasc Anesth 18:175-9. 2004
    ..To determine the femoral-to-radial arterial pressure gradient, as well as the factors associated with them, in patients receiving cardiopulmonary bypass (CPB) with profound hypothermia and circulatory arrest...
  68. ncbi Time course of changes in collateral blood flow and isolated vessel size and gene expression after femoral artery occlusion in rats
    Barry M Prior
    Biomedical Sciences, E102 Vet Med Bldg, Univ of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 287:H2434-47. 2004
    ..time course of enlargement and gene expression of a collateral vessel that enlarges following occlusion of the femoral artery and to relate these responses to the increases in collateral-dependent blood flow to the calf muscles in vivo...
  69. pmc Clinical and pathological assessment of different suture techniques for microvascular anastomosis in rat femoral artery
    Khaled Radad
    Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
    J Vet Sci 8:269-73. 2007
    This study examined the clinical and pathological features after a microvascular anastomosis of a rat femoral artery using four different suture techniques. Sixty Sprage-Dawely rats were divided randomly into 4 groups...
  70. pmc Peripheral mu-opioid receptors attenuate the augmented exercise pressor reflex in rats with chronic femoral artery occlusion
    Hirotsugu Tsuchimochi
    Penn State Heart and Vascular Institute, 500 University Dr, Mail Code H047, Hershey Medical Center, Hershey, PA 17033, USA
    Am J Physiol Heart Circ Physiol 299:H557-65. 2010
    ..DAMGO; 1 microg) into the abdominal aorta of decerebrated rats in which one femoral artery had been occluded 72 h previously (n = 10) and in control rats whose femoral arteries were freely perfused (n =..
  71. ncbi Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery
    Chihiro Hosoda
    Department of Pharmacology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Am J Physiol Heart Circ Physiol 293:H514-9. 2007
    ..In this study, we examined the neointimal formation after vascular injury in the femoral artery of alpha(1A)-knockout (alpha(1A)-KO), alpha(1B)-KO, alpha(1D)-KO, alpha(1A)-/alpha(1B)-AR double-KO (alpha(1AB)..
  72. ncbi Cost per day of patency: understanding the impact of patency and reintervention in a sustainable model of healthcare
    Michael C Stoner
    Department of Cardiovascular Sciences, East Carolina University, Greenville, NC 27858 4354, USA
    J Vasc Surg 48:1489-96. 2008
    ..Herein we describe an amortized cost model that accounts for procedural costs, durability, and re-intervention costs...
  73. ncbi Nitinol stent implantation in long superficial femoral artery lesions: 12-month results of the DURABILITY I study
    Marc Bosiers
    Department of Vascular Surgery, AZ St Blasius, Dendermonde, Belgium
    J Endovasc Ther 16:261-9. 2009
    To evaluate the long-term efficacy and integrity of the PROTEGE EverFlex stent in superficial femoral artery (SFA) lesions in symptomatic patients with peripheral artery disease (PAD).
  74. ncbi Wall shear stress in the superficial femoral artery of healthy adults and its response to postural changes and exercise
    O Schlager
    Division of Angiology, Department of Medicine II, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur J Vasc Endovasc Surg 41:821-7. 2011
    ..of WSS might contribute to the typical distribution of atherosclerotic lesions along the superficial femoral artery (SFA)...
  75. pmc Blockade of acid sensing ion channels attenuates the augmented exercise pressor reflex in rats with chronic femoral artery occlusion
    Hirotsugu Tsuchimochi
    Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Physiol 589:6173-89. 2011
    We found previously that static contraction of the hindlimb muscles of rats whose femoral artery was ligated evoked a larger reflex pressor response (i.e...
  76. pmc Femoral artery occlusion increases expression of ASIC3 in dorsal root ganglion neurons
    Jiahao Liu
    Pennsylvania State Heart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Heart Circ Physiol 299:H1357-64. 2010
    ..Also, femoral artery occlusion augments the reflex sympathetic nerve response in rats...
  77. ncbi Obesity promotes injury induced femoral artery thrombosis in mice
    Nobuo Nagai
    Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
    Thromb Res 122:549-55. 2008
    ..80; p<0.0001) or Factor V levels (r=0.65; p=0.003). Thus, this injury induced femoral artery thrombosis model in mice establishes experimentally a correlation between obesity and prothrombotic tendency.
  78. ncbi Results of the Protégé EverFlex 200-mm-long nitinol stent (ev3) in TASC C and D femoropopliteal lesions
    Marc Bosiers
    Department of Vascular Surgery, Algemeen Ziekenhuis Sint Blasius, Dendermonde, Belgium
    J Vasc Surg 54:1042-50. 2011
    ....
  79. ncbi Vessel-specific rate of vasorelaxation is slower in diabetic rats
    Juan M Murias
    School of Kinesiology, Western University, London, ON, Canada
    Diab Vasc Dis Res 10:179-86. 2013
    ..4%·s(-1)) in both groups and in the iliac compared to the aorta (p < 0.05) in the control group. In conclusion, the vasorelaxation response was vessel specific with a slower rate of adjustment in diabetic compared to control animals...
  80. ncbi Common femoral artery ligation and local debridement: a safe treatment for infected femoral artery pseudoaneurysms
    S Arora
    VA Medical Center and George Washington University School of Medicine, Washington, DC, USA
    J Vasc Surg 33:990-3. 2001
    The management of infected femoral artery pseudoaneurysms (IFAPs) is difficult and controversial...
  81. pmc Case report: Common femoral artery ligation after sarcoma resection in an infant
    Luis Aponte-Tinao
    Carlos E Ottolenghi Institute of Orthopedics, Italian Hospital of Buenos Aires, Potosí 4247, 1199 Buenos Aires, Argentina
    Clin Orthop Relat Res 469:609-12. 2011
    ..Thus a surgeon can consider tumor and vessel resection, without the need for vascular reconstruction...
  82. ncbi Apolipoprotein C1 and apolipoprotein E are differentially expressed in atheroma of the carotid and femoral artery
    Hyun Seon Eo
    Samsung Biomedical Research Institute, Seoul, Korea
    J Surg Res 144:132-7. 2008
    ..A number of the genes and proteins as the causes of carotid atherosclerotic disease have been recently reported, but the major factors for atherosclerosis have still not been identified...
  83. ncbi Percutaneous transluminal dilatation of inadvertent partial or complete occlusion of the femoral artery caused by Angio-Seal deployment for puncture site closure after cardiac catheterization
    Martin Brueck
    Department of Cardiology, Interventional Radiology, Clinic of Wetzlar, Wetzlar, Germany
    J Invasive Cardiol 22:353-7. 2010
    ..the efficacy of percutaneous transluminal angioplasty (PTA) of inadvertent occlusion or severe stenosis of the femoral artery after deployment of the Angio-Seal closure device...
  84. pmc Framingham risk score is associated with femoral artery intima-media thickness in asymptomatic young adults (the Bogalusa heart study)
    Timir K Paul
    Tulane Center for Cardiovascular Health, Tulane School of Public Health, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Atherosclerosis 213:627-31. 2010
    b>Femoral artery intima-media thickness (IMT), like carotid IMT, is a surrogate indicator of atherosclerotic coronary and peripheral vascular diseases...
  85. ncbi Endovascular repair of profunda femoral artery false aneurysms using covered stents
    George N Kouvelos
    Department of Surgery Vascular Surgery Unit, University of Ioannia, Greece
    Vascular 19:51-4. 2011
    Pseudoaneurysms of the profunda femoral artery (PFA) have been reported following different types of trauma, mostly iatrogenic...
  86. ncbi ACE inhibition restores the vasodilator potency of the endothelium-derived relaxing factor, L-S-nitrosocysteine, in conscious Spontaneously Hypertensive rats
    Stephen J Lewis
    Department of Physiology and Pharmacology, Institute of Comparative Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 7389, USA
    Vascul Pharmacol 44:491-507. 2006
    ....
  87. ncbi How to interpret data from the superficial femoral artery stenting trials and registries
    Peter H Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden Road, Suite 1500, Houston, TX 77030, USA
    Semin Vasc Surg 23:138-47. 2010
    ..trials on the efficacy of drug-eluting stent placement and covered stent implantation of the superficial femoral artery are also discussed...
  88. pmc Assessment of endothelial function of large, medium, and small vessels: a unified myograph
    Xiao Lu
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA
    Am J Physiol Heart Circ Physiol 300:H94-H100. 2011
    ..In conclusion, an isovolumic myograph was used to unify arterial vasoreactivity from large to small arteries and shows the uniformity of wall stress and %tension throughout the range of vessel sizes...
  89. ncbi Effect of exercise on frequency of stent fracture in the superficial femoral artery
    Osamu Iida
    Cardiovascular Division, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan
    Am J Cardiol 98:272-4. 2006
    Stent fracture has emerged as a new problem in the percutaneous transluminal angioplasty of the superficial femoral artery (SFA). The aim of our study was to delineate the factors influencing nitinol stent fracture in the SFA...
  90. ncbi Delayed presentation of a posttraumatic superficial femoral artery pseudoaneurysm
    Stefano Schena
    University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, IL, USA
    J Am Coll Surg 203:250-1. 2006
  91. ncbi Real-time imaging of mechanically injured femoral artery in mice reveals a biphasic pattern of leukocyte accumulation
    Mizuko Osaka
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, School of Medicine, Keio University, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 292:H1876-82. 2007
    ..In this study, we documented the recruitment of leukocytes to the murine femoral artery after a wire injury...
  92. pmc The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study
    Feiyu Li
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 12:37. 2010
    ..This study investigated associations of plaque eccentricity with plaque components and morphology in the proximal superficial femoral artery using cardiovascular magnetic resonance (CMR).
  93. pmc Alpha-adrenergic inhibition increases collateral circuit conductance in rats following acute occlusion of the femoral artery
    Jessica C Taylor
    Department of Biomedical Sciences, E102 Vet Medical Bldg, University of Missouri, Columbia, MO 65211, USA
    J Physiol 586:1649-67. 2008
    ..to collateral circuit vascular resistance in the hindlimb following acute unilateral occlusion of the femoral artery in rats...
  94. ncbi The anatomic relationship between the common femoral artery and common femoral vein in frog leg position versus straight leg position in pediatric patients
    Jennifer W Hopkins
    Department of Pediatrics, University of Louisville Health Sciences Center, Kosair Children s Hospital, Louisville, KY, USA
    Acad Emerg Med 16:579-84. 2009
    Overlap of the femoral artery (FA) on the femoral vein (FV) has been shown to occur in pediatric patients. This overlap may increase complications such as arterial puncture and failed insertions of central venous lines (CVLs)...
  95. ncbi Emergency stent grafting after unsuccessful surgical repair of a mycotic common femoral artery pseudoaneurysm in a drug abuser
    Tommaso Lupattelli
    Department of Interventional Radiology, Multimedica IRCCS, Sesto San Giovanni, Milan, Italy
    Cardiovasc Intervent Radiol 32:347-51. 2009
    ..We report a case of rupturing mycotic pseudoaneurysm of the left common femoral artery treated by surgical resection followed by vessel reconstruction with autologous material...
  96. ncbi Mycobacterium bovis abdominal aortic and femoral artery aneurysms following intravesical bacillus Calmette-Guérin therapy for bladder cancer
    Cecilia T Costiniuk
    Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    Cardiovasc Pathol 19:e29-32. 2010
    ..Infectious complications of intravesical bacillus Calmette-Guérin (BCG) therapy are rare, but these have included a handful of cases of mycotic aneurysm...
  97. ncbi Randomized comparison of ePTFE/nitinol self-expanding stent graft vs prosthetic femoral-popliteal bypass in the treatment of superficial femoral artery occlusive disease
    Karen McQuade
    Department of Vascular Surgery, Baylor University Medical Center, Dallas, Texas 75226, USA
    J Vasc Surg 49:109-15, 116.e1-9; discussion 116. 2009
    A randomized prospective study comparing the treatment of superficial femoral artery occlusive disease percutaneously with an expanded polytetrafluoroethylene (ePTFE)/nitinol self-expanding stent graft (stent-graft) vs surgical femoral to ..
  98. ncbi Percutaneous transluminal angioplasty of suture-mediated closure device-related femoral artery stenosis or occlusive disease
    Y J Kim
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Br J Radiol 82:486-90. 2009
    ..angiography revealed focal segmental steno-occlusion (<1 cm) in the common femoral or proximal superficial femoral artery in four patients and long segmental occlusion (>1 cm) in the external iliac and common femoral arteries in ..
  99. ncbi PTFE bypass or thrupass for superficial femoral artery occlusion? A randomised controlled trial
    M Lepantalo
    Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Vasc Endovasc Surg 37:578-84. 2009
    ..Less morbidity and better cost-effectiveness are suggested to be achieved in the treatment of chronic lower limb ischaemia with endovascular treatment compared to surgical treatment...
  100. ncbi Past, present and future of femoropopliteal stenting
    Martin Schillinger
    Department of Angiology, Medical University Vienna, Austria
    J Endovasc Ther 16:I147-52. 2009
    ..From a current perspective, femoropopliteal stenting remains the Achilles' heel of the interventionist...
  101. ncbi Primary nitinol stenting for femoropopliteal disease
    Mark W Mewissen
    Vascular Center, St Luke s Medical Center, 2801 W Kinnickinnic River Parkway, Suite 514, Milwaukee, WI 53215, USA
    J Endovasc Ther 16:II63-81. 2009
    ..Development and implementation of uniform reporting and surveillance standards is important for optimizing current and future research...

Research Grants63

  1. Laser Catheter for Dethrombosis of Arterial Occlusion
    Brant Watson; Fiscal Year: 2005
    ..We will then insert the device via a femoral artery under X-ray fluoroscopy, first to examine the effectiveness of this device to dilate the rat CCA, and then to ..
  2. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..Unfortunately, only one-third of patients have a patent artery one year after balloon angioplasty of the femoral artery [4]...
  3. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..Cases and controls will have femoral artery microvascular endothelial function assessed invasively in the cardiac catheterization laboratory using Doppler ..
  4. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013
    ..large animal model of acute LIRI (n=6 minipigs per group) induced by an endovascular balloon occlusion of the femoral artery for 6 h, we will establish the dose-response of parenteral CM (0, 10, 30, 80 mg/kg/day TID) initiated 10 min ..
  5. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..Three weeks before study catheters will be inserted under general anesthesia into the femoral artery, the hepatic portal vein and the hepatic vein, as well as in other vessels and sites as needed (splenic and ..
  6. Integrated MRI-Based Examination for Evaluation of Peripheral Arterial Disease
    Felix W Wehrli; Fiscal Year: 2010
    ..from the time lag of the systolic pressure wave between a location in the carotid artery and a point in the femoral artery using tonometry, an approach that is problematic since the path length the blood travels can only be estimated...
  7. GCL-M Regulation of Angiogenesis
    CHRISTOPHER BRUCE PATTILLO; Fiscal Year: 2010
    ..with a VEGF containing diffusion disk to determine vascular recruitment, and another group will have their femoral artery ligated and angiogenesis measured over a period of 21 days...
  8. The role of smooth muscle PPAR gamma in neointima formation
    SETH BERNAT FURGESON; Fiscal Year: 2013
    ..In Aim Three, we will examine the effects of the agents in vivo during femoral artery wire injury...
  9. Role of Femoral Atherosclerosis in Functional Status, CVD Events, and Mortality
    CHRISTINA LYNN WASSEL; Fiscal Year: 2013
    ..Measures such as femoral artery intima media thickness (IMT) and femoral artery compliance, as well as presence and characteristics of ..
  10. Targeting Inflammation to Treat Cardiovascular Aging in Humans
    Gary L Pierce; Fiscal Year: 2013
    ..will test the hypothesis that chronic inhibition of inflammation will improve aortic wall stiffness (carotid- femoral artery pulse wave velocity;proximal aortic characteristic impedance);Aim 2 will test the hypothesis that chronic ..
  11. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn J Pelletier; Fiscal Year: 2010
    ..fail resuscitative efforts in the University of Michigan Emergency Department will undergo cannulation of the femoral artery and vein after pronouncement of death...
  12. In vivo model of hypoxia in Ewing Sarcoma
    Joanna B Kitlinska; Fiscal Year: 2013
    ..To provide a direct proof for this notion, we propose developing a novel animal model by performing femoral artery ligation (FAL) in mice bearing orthotopic ESFT xenografts in their gastrocnemius muscles, followed by excision ..
  13. Adenosine Receptors and Atherogenesis
    Katya Ravid; Fiscal Year: 2012
    ..A2bAR KO mice display greater lesion formation after guidewire-induced femoral artery injury...
  14. The role of HMGB-1 and innate immunity in promoting angiogenesis after ischemia
    Ulka Sachdev; Fiscal Year: 2013
    ..endothelial tube formation, and results in greater muscle necrosis when given to mice that have undergone femoral artery ligation, which is a recognized model of angiogenesis...
  15. Commercialization of Tissue Lined Stent Graft for Dialysis Access Failure
    DON GUSTAVSON; Fiscal Year: 2013
    ..excellent performance in animal and international human clinical studies for both dialysis access failure and femoral artery occlusive disease...
  16. Nox4 and Vascular Smooth Muscle Differentiation
    Kathy K Griendling; Fiscal Year: 2013
    ..In addition, we will use a femoral artery wire injury model in Poldip2 heterozygous mice to create a situation in vivo in which VSMCs are stimulated to ..
  17. Novel Biological Tissue Lined Vascular Stent Crimping and Delivery System
    MICHAEL JOHN WIGGINS; Fiscal Year: 2010
    ..Of the arteries in the lower extremity, the superficial femoral artery (SFA) is the most commonly affected by PAD with over 50% of all PAD involving the SFA...
  18. Vascular Delivery of alpha-Sarcoglycan for LGMD2D
    JERRY ROY MENDELL; Fiscal Year: 2013
    ..rh.74 can effectively deliver hSGCA to specific muscle groups through the femoral artery in the non-human primate...
  19. MRI Assessment of Vascular Reactivity
    Felix W Wehrli; Fiscal Year: 2013
    ..Key elements of the protocol comprise high-speed projection mapping of time-resolved femoral artery velocity at baseline and during hyperemia, simultaneously with a method for quantifying the dynamics of venous ..
  20. Modeling Diabetic Cardiomyopathy and Microangiopathy
    EVAN DALE ABEL; Fiscal Year: 2010
    ..artery ligation, or reverse impaired recovery of hind-limb perfusion that occurs in diabetic animals following femoral artery occlusion...
  21. Biomedical and Functional Studies of CD39
    AARON JACOB MARCUS; Fiscal Year: 2011
    ..These models include: a) Transluminal wire injury of mouse femoral artery, in which we will ascertain the role of CD39 in both the initial platelet- dependent stage, as well as the ..
  22. KLF4 and Transcriptional Control of Neovascularization
    Anne Hamik; Fiscal Year: 2013
    ..In hindlimb ischemia studies endothelial KLF4 overexpression leads to poor blood flow immediately post femoral artery ligation (decreased function of native collaterals), but enhanced collateral remodeling during the recovery ..
  23. Surrogate measures of endothelial dysfunction with integrated MRI
    MICHAEL LANGHAM; Fiscal Year: 2013
    ..to the clinic are comprised of techniques for simultaneous mapping of time-resolved velocity in the femoral artery and for quantifying the time-course of blood oxygen resaturation in the femoral vein during hyperemia, ..
  24. Function of the 130kDa MLCK in vasculature physiology and pathophysiology
    BRIAN PAUL HERRING; Fiscal Year: 2010
    ..A wire induced injury of the mouse femoral artery and collateral artery remodeling following hind limb ischemia will be used...
  25. Stem Cells in Vascular Remodeling
    Song Li; Fiscal Year: 2013
    ..we have isolated and characterized MVSCs from human atherosclerotic plaques, coronary artery, aorta and femoral artery. Based on our preliminary studies, we hypothesize that MVSC differentiation is a major source of proliferative/..
  26. The role of satellite cells in adult skeletal muscle growth and maintenance
    Charlotte A Peterson; Fiscal Year: 2013
    ..of satellite cells in the response of skeletal muscle to hind lim ischemia (HLI) using the standard model of femoral artery ligation and excision...
  27. Improved Adventitial Rapamycin Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2013
    ..Unfortunately, only one-third of patients have a patent artery one year after balloon angioplasty of the femoral artery [4]...
  28. Diverse Strategies to Correct the Dystrophin Gene Using Vascular Delivery (U54)
    JERRY ROY MENDELL; Fiscal Year: 2010
    ..Our proposal revolves around this central point and gene delivery to the legs through the femoral artery is the starting place. In project 1, rAAV...
  29. Clinically Translatable Nanotechnology: Hemostasis and Neuroprotection
    Erin Lavik; Fiscal Year: 2010
    ..nanoparticles based on FDA-approved materials that is administered intravenously and halves bleeding time in a femoral artery injury model...
  30. Cardioscopy New Platform for Less Invasive Surgery on the Beating Heart
    Tomislav Mihaljevic; Fiscal Year: 2013
    ..the LV apex via a small thoracotomy or small subxiphoid incision or across the aortic valve via the carotid or femoral artery percutaneous approach...
  31. NEUROTRANSMITTERS AND VENTILATORY CONTROL
    EARL OLSON; Fiscal Year: 1990
    ..Unanesthetized, unrestrained rats prepared with chronically indwelling femoral artery catheters will be used to obtain arterial blood gas and acid-base measurements...
  32. Resorbable Small Diameter Vascular Grafts
    Eun Seok Gil; Fiscal Year: 2010
    ..proposal addresses a critical outstanding clinical need for small diameter vascular grafts for coronary or femoral artery bypass in patients with advanced vascular disease and no suitable blood vessels to harvest, the common ..
  33. Femoral Plaque Composition, Oxidative Stress, and Coronary Events
    Mary Mcgrae McDermott; Fiscal Year: 2013
    ..no prior prospective studies have established whether presence of lipid-rich necrotic core in the superficial femoral artery (SFA) predicts atherosclerotic disease progression either locally or in distant vascular beds...
  34. HYPOGLYCEMIC ACTION OF 2-CHLOROPROPIONATE
    Robert Harris; Fiscal Year: 1980
    ..An intact rat model with cannulae in the left femoral artery and vein will be used...
  35. THE EFFECTS OF COCAINE ON FETAL OXYGENATION
    James Woods; Fiscal Year: 1993
    ..In Phase II (fetal) studies surgical instrumentation at 110 days will consist of catheters in the maternal femoral artery and vein, fetal umbilical vein and fetal aorta and placement of an electromagnetic flow probe on the fetal ..
  36. Translational Studies of ADAMTS7 a Novel GWAS Locus for Coronary Atherosclerosis
    Muredach P Reilly; Fiscal Year: 2013
    ..preliminary studies suggest that Adamts7-/- gene deletion in mice reduces the in vivo neointimal response to femoral artery injury...
  37. Dystrophin restoration in two animal models of Duchenne Muscular Dystrophy
    LOUISE RODINO; Fiscal Year: 2009
    ..This proposal revolves around this central point and gene delivery to the legs through the femoral artery is the starting point...
  38. Osteocyte reaction to decreased bone fluid flow
    Shijing Qiu; Fiscal Year: 2003
    ..In the proposed study, the right femoral artery in 74 adult Sprague-Dawley rats will be ligated to decrease CIFF in the tibia...
  39. Inflammatory Mechanisms in Arteriogenesis
    Armin Helisch; Fiscal Year: 2012
    ..of the primarily pro-inflammatory cell adhesion protein osteopontin in collateral artery growth in a mouse femoral artery ligation model...
  40. Clinical Implications of Peripheral Plaque Morphology
    Daniel Clair; Fiscal Year: 2007
    ..claudication, based on our hypothesis that statin therapy will result in stabilization or regression of femoral artery plaque, differences best assessed with high resolution imaging studies...
  41. Circuit Weight Training and Blood Pressure Regulation in Prehypertension
    William Cooke; Fiscal Year: 2007
    ..Doppler ultrasound probes, pulse waves velocities between the left common carotid artery and the left femoral artery, and the left femoral artery and the superior dorsalis pedis artery will be obtained...
  42. Study of design variables of the endovascular graft
    MADHAVAN RAGHAVAN; Fiscal Year: 2007
    ..endovascular repair, the endovascular graft (EVG) - a vascular graft covered by stents - is passed through a femoral artery to the aneurysm...
  43. RESUSCITATION AFTER PROLONGED CARDIAC ARREST
    Max Weil; Fiscal Year: 1990
    ..We propose to compare extracorporeal pump oxygenation (ECPO) utilizing femoral artery and jugular vein access and internal cardiac massage (ICM) after thoracotomy as interventions for cardiac ..
  44. Effects of Diabetes Mellitus on the Development of Collateral Criculation
    Divya Gupta; Fiscal Year: 2009
    ..Four treatment groups will be used (femoral artery ligation and excision in normals and and diabetics and sham operation in normals and diabetics)...
  45. Effect of lipid modification on peripheral arterial disease (PAD)
    Christie Ballantyne; Fiscal Year: 2007
    ..We will recruit a total of 120 patients with symptomatic femoral artery occlusive disease in one leg...
  46. Early Growth Response-1 (Egr-1), PKC Beta and Restenosis
    Shi Fang Yan; Fiscal Year: 2007
    ..mice genetically deficient in egr-1 or PKCbeta display significantly decreased neointimal expansion after femoral artery denudation injury...
  47. ULTRASOUND ENHANCED THROMBOLYSIS AND MONITOR
    MARK MOEHRING; Fiscal Year: 2000
    ..The innovative aspect of this proposal is to explore these advances in an in vivo rabbit femoral artery model of the human middle cerebral artery to develop a noninvasive and cost effective method of thrombolysis ..
  48. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    MOHAMED BAYORH; Fiscal Year: 1990
    ..Biochemical and endocrine status will be assessed by withdrawal of blood from arterial lines implanted in the femoral artery. Catecholamines will be assayed by the radioenzymatic-TLC method...
  49. Sealing Air Leaks by Inductive Coagulation Following Lung Surgery
    KEVIN MARCHITTO; Fiscal Year: 2006
    ..Pilot testing of the device has proven feasibility for sealing dialysis needle perforations, femoral artery punctures, and anastomosing arteries. The non-contact process is safe, easy to use and inexpensive...
  50. Miniaturization of Catheters and Pressure Sensors
    Huntly Millar; Fiscal Year: 2002
    ..high-fidelity silicon pressure sensor to be mounted at the catheter tip, suitable for introduction through the femoral artery of a 20- gram transgenic mouse for measuring blood pressure and rate of change of blood pressure (dP/dt) ..
  51. Vascular Biology: Exercise Training and Vascular Disease
    M Harold Laughlin; Fiscal Year: 2010
    ..wall stretch (Ts) is critical for retention of very large collateral arteries sustaining perfusion following femoral artery occlusion. Tw and Ts will be increased with a unique A-V shunt placed distal to the occlusion...
  52. A Nanofibrous Biocomposite Small-Diameter Graft
    Matthew Phaneuf; Fiscal Year: 2006
    ..Lastly, the ESDC graft showed excellent handling characteristics when implanted into a canine femoral artery in a preliminary in vivo evaluation of the graft...
  53. Sonothrombolysis of Vascular Clots with Targeted Bubbles
    Evan Unger; Fiscal Year: 2007
    ..for efficient ultrasound-mediated thrombolysis, 4) conduct preclinical studies in the occluded rabbit femoral artery model to determine safety and efficacy of targeted microbubbles and ultrasound using parameters based upon ..
  54. Cell cycle control of vascular remodeling
    RICHARD ASSOIAN; Fiscal Year: 2009
    ..In Aim 3, we will use femoral artery injury in knock-out and transgenic mice to determine the importance of the PGI2-IP-Skp2 pathway on SMC ..
  55. Estradiol and Gene Expression in Intimal Hyperplasia
    John Hoch; Fiscal Year: 2006
    ..Specific Aim I: Evaluate E2 for a dose dependent effect on IH and macrophage accumulation in a rat femoral artery interposition vein graft. Five groups of male rats will have pellets implanted s.c...
  56. CIRCULATORY AND METABOLIC ADAPTATIONS IN ISCHEMIC LIMBS
    Martin Kushmerick; Fiscal Year: 1991
    ..ischemic lower limb of the rat as an animal model and study it at intervals after ligation of the superficial femoral artery and in response to graded exercise training...
  57. ATHEROSCLEROSIS PROGRESSION/REGRESSION IN MAN
    DAVID BLANKENHORN; Fiscal Year: 1990
    ..The endpoint is a computer derived comparison of averaged atherosclerosis in 5 cm. segments of femoral artery as seen by angiography at two year intervals...
  58. MECHANISMS OF EXERCISE HYPEREMIA
    Lana Kaiser; Fiscal Year: 1992
    ..in exercise hyperemia, (b) to further characterize the mechanism of flow-dependent dilation in the canine femoral artery, and (c) to determine the role of endothelial cells in the dilation and growth of collateral vessels during ..
  59. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    HERBERT ASHLINE; Fiscal Year: 1992
    ..will be induced with streptozotocin after the development of hypertension as monitored by cannulation of the femoral artery. Presence of diabetes will be ascertained by showing that urinary glucose exceeds 1%; in some cases, plasma ..
  60. STIMULANT ABUSE BEHAVIOR AND PHARMACOKINETICS
    CHYAN LAU; Fiscal Year: 2000
    ..Experiments with rats implanted with dual catheters (jugular vein and femoral artery) will determine the concentration-effect relations after constant-rate i.v...
  61. GENE THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY
    Jon Wolff; Fiscal Year: 2004
    ..We have shown that the intravascular injection of naked plasmid DNA (pDNA) into the femoral artery of rats leads to very high foreign gene expression in skeletal muscle throughout the leg and without damaging ..
  62. EXERCISE TRAINING AND PERIPHERAL ARTERIAL INSUFFICIENCY
    RONALD TERJUNG; Fiscal Year: 2004
    ..Our previous work, using a claudicate rat model produced by femoral artery occlusion, has shown that these adaptations improve muscle performance and increase collateral-dependent blood ..
  63. FLOW DEPENDENT DILATION--MECHANISMS AND SIGNIFICANCE
    Lana Kaiser; Fiscal Year: 1991
    ..Finally, we will investigate the effect of canine heartworm (D. immitis) infection on femoral artery vasoreactivity in vivo and in vitro...