coronary vessels

Summary

Summary: The veins and arteries of the HEART.

Top Publications

  1. ncbi Coronary plaque classification with intravascular ultrasound radiofrequency data analysis
    Anuja Nair
    Department of Biomedical Engineering, The Cleveland Clinic Foundation, OH 44195, USA
    Circulation 106:2200-6. 2002
  2. ncbi Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk
    Michael Joner
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 48:193-202. 2006
  3. ncbi Evaluation of the second generation of a bioresorbable everolimus drug-eluting vascular scaffold for treatment of de novo coronary artery stenosis: six-month clinical and imaging outcomes
    Patrick W Serruys
    Thoraxcenter, Ba 583, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Circulation 122:2301-12. 2010
  4. ncbi A prospective natural-history study of coronary atherosclerosis
    Gregg W Stone
    Columbia University Medical Center New York Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY 10022, USA
    N Engl J Med 364:226-35. 2011
  5. pmc A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse
    Erhe Gao
    Center for Translational Medicine, George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Thomas Jefferson University, 1025 Walnut St, Room 302, Philadelphia, PA 19107, USA
    Circ Res 107:1445-53. 2010
  6. pmc Coronary artery calcium score and risk classification for coronary heart disease prediction
    Tamar S Polonsky
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA
    JAMA 303:1610-6. 2010
  7. ncbi Comparison of inflammatory response after implantation of sirolimus- and paclitaxel-eluting stents in porcine coronary arteries
    Gregory J Wilson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Circulation 120:141-9, 1-2. 2009
  8. ncbi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
  9. ncbi Quantitative ex vivo and in vivo comparison of lumen dimensions measured by optical coherence tomography and intravascular ultrasound in human coronary arteries
    Nieves Gonzalo
    Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, Paises Bajos
    Rev Esp Cardiol 62:615-24. 2009
  10. ncbi Characterization of human atherosclerosis by optical coherence tomography
    Hiroshi Yabushita
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Circulation 106:1640-5. 2002

Detail Information

Publications269 found, 100 shown here

  1. ncbi Coronary plaque classification with intravascular ultrasound radiofrequency data analysis
    Anuja Nair
    Department of Biomedical Engineering, The Cleveland Clinic Foundation, OH 44195, USA
    Circulation 106:2200-6. 2002
    ..Spectral analysis of backscattered intravascular ultrasound (IVUS) data has potential for real-time in vivo plaque classification...
  2. ncbi Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk
    Michael Joner
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 48:193-202. 2006
    ..This study examined human drug-eluting stents (DES) to determine the long-term effects of these stents on coronary arterial healing and identified mechanisms underlying late stent thrombosis (LST)...
  3. ncbi Evaluation of the second generation of a bioresorbable everolimus drug-eluting vascular scaffold for treatment of de novo coronary artery stenosis: six-month clinical and imaging outcomes
    Patrick W Serruys
    Thoraxcenter, Ba 583, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Circulation 122:2301-12. 2010
    ..Nevertheless, late luminal loss was less than that observed with bare metal stents. To maintain the mechanical integrity of the device up to 6 months, the scaffold design and manufacturing process of its polymer were modified...
  4. ncbi A prospective natural-history study of coronary atherosclerosis
    Gregg W Stone
    Columbia University Medical Center New York Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY 10022, USA
    N Engl J Med 364:226-35. 2011
    ..Atherosclerotic plaques that lead to acute coronary syndromes often occur at sites of angiographically mild coronary-artery stenosis. Lesion-related risk factors for such events are poorly understood...
  5. pmc A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse
    Erhe Gao
    Center for Translational Medicine, George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Thomas Jefferson University, 1025 Walnut St, Room 302, Philadelphia, PA 19107, USA
    Circ Res 107:1445-53. 2010
    ..We developed a novel and rapid surgical method to induce MI that does not require ventilation...
  6. pmc Coronary artery calcium score and risk classification for coronary heart disease prediction
    Tamar S Polonsky
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA
    JAMA 303:1610-6. 2010
    ..The coronary artery calcium score (CACS) has been shown to predict future coronary heart disease (CHD) events. However, the extent to which adding CACS to traditional CHD risk factors improves classification of risk is unclear...
  7. ncbi Comparison of inflammatory response after implantation of sirolimus- and paclitaxel-eluting stents in porcine coronary arteries
    Gregory J Wilson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Circulation 120:141-9, 1-2. 2009
    ....
  8. ncbi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
    ..However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups...
  9. ncbi Quantitative ex vivo and in vivo comparison of lumen dimensions measured by optical coherence tomography and intravascular ultrasound in human coronary arteries
    Nieves Gonzalo
    Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, Paises Bajos
    Rev Esp Cardiol 62:615-24. 2009
    ..The objectives were to compare the lumen measurements obtained ex vivo in human coronary arteries using IVUS, OCT and histomorphometry, and in vivo in patients using IVUS and OCT with and without balloon occlusion...
  10. ncbi Characterization of human atherosclerosis by optical coherence tomography
    Hiroshi Yabushita
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Circulation 106:1640-5. 2002
    ..The aim of this study was to establish objective OCT image criteria for atherosclerotic plaque characterization in vitro...
  11. ncbi Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial
    Holger Thiele
    Universität Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Lancet 379:923-31. 2012
    ..However, the safety and efficacy of intracoronary versus standard intravenous bolus application in patients with ST-elevation myocardial infarction (STEMI) undergoing this intervention has not been tested in a large-scale clinical trial...
  12. ncbi Effect of intensive statin therapy on regression of coronary atherosclerosis in patients with acute coronary syndrome: a multicenter randomized trial evaluated by volumetric intravascular ultrasound using pitavastatin versus atorvastatin (JAPAN-ACS [Japan
    Takafumi Hiro
    Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan
    J Am Coll Cardiol 54:293-302. 2009
    ....
  13. ncbi Coronary microvascular dysfunction
    Paolo G Camici
    Medical Research Council Clinical Sciences Centre Hammersmith Hospital, and National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 356:830-40. 2007
  14. ncbi Patient-specific modeling of blood flow and pressure in human coronary arteries
    H J Kim
    Aerospace Engineering Sciences, University of Colorado at Boulder, Boulder, CO 80309, USA
    Ann Biomed Eng 38:3195-209. 2010
    ..To model coronary flow realistically, the compressive force of the heart acting on the coronary vessels needs to be included...
  15. ncbi Optical coherence tomography assessment of the acute effects of stent implantation on the vessel wall: a systematic quantitative approach
    N Gonzalo
    Thoraxcenter, Erasmus MC, 3015 CE Rotterdam, The Netherlands
    Heart 95:1913-9. 2009
    ....
  16. ncbi Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease
    Habib Samady
    Department of Medicine, Emory University School of Medicine, 1365 Clifton Rd, Ste F606, Atlanta, GA 30322, USA
    Circulation 124:779-88. 2011
    ..We hypothesized that low-WSS segments in patients with coronary artery disease develop plaque progression and high-WSS segments develop necrotic core progression with fibrous tissue regression...
  17. ncbi Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage
    G J Ughi
    Department of Cardiovascular Diseases, Catholic University Leuven, Leuven, Belgium
    Int J Cardiovasc Imaging 28:229-41. 2012
    ..This will be important for the integration of this technology in clinical routine and for the analysis of datasets of larger clinical trials...
  18. ncbi Incomplete stent apposition and very late stent thrombosis after drug-eluting stent implantation
    Stephane Cook
    Department of Cardiology, University Hospital Bern, 3010 Bern, Switzerland
    Circulation 115:2426-34. 2007
    ..The present study investigated differences of the stented segment between patients with and without very late stent thrombosis with the use of intravascular ultrasound...
  19. ncbi Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis
    Rajat Deo
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Coll Cardiol 44:1812-8. 2004
    ..We sought to evaluate the association between plasma levels of monocyte chemoattractant protein (MCP)-1 and the risk for subclinical atherosclerosis...
  20. ncbi Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
    T Matsui
    Program in Cardiovascular Gene Therapy, CVRC, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:330-5. 2001
    ..Akt may represent an important nodal target for therapy in ischemic and other heart disease...
  21. ncbi Optical coherence tomography: high resolution intravascular imaging to evaluate vascular healing after coronary stenting
    Giulio Guagliumi
    Cardiovascular Department, Ospedali Riuniti di Bergamo, Bergamo, Italy
    Catheter Cardiovasc Interv 72:237-47. 2008
    ..The value of these improvements must be gauged by the degree of impact in DES technology and patient care...
  22. ncbi Intravascular ultrasound: novel pathophysiological insights and current clinical applications
    S E Nissen
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 103:604-16. 2001
    ..Ultrasound has proven useful in evaluating brachytherapy. New and emerging applications for IVUS are continuing to evolve, particularly in atherosclerosis regression-progression trials...
  23. ncbi Coronary calcium score improves classification of coronary heart disease risk in the elderly: the Rotterdam study
    Suzette E Elias-Smale
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 56:1407-14. 2010
    ....
  24. ncbi Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells
    Andrew Y Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, USA
    Hypertension 47:74-80. 2006
    ..These results suggest that LR clustering occurs in coronary endothelial cells. The formation of redox signaling platforms on the cell membrane mediates transmembrane signaling of death receptors, resulting in endothelial dysfunction...
  25. ncbi Impact of atherosclerotic plaque composition on coronary microembolization during percutaneous coronary interventions
    Dirk Bose
    Dept of Cardiology, West German Heart Center, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Basic Res Cardiol 103:587-97. 2008
    ....
  26. ncbi CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease
    T J Brown
    Department of Pediatrics, Northwestern University Medical School, and Children's Memorial Hospital, Chicago, Illinois 60611, USA
    J Infect Dis 184:940-3. 2001
    ....
  27. pmc Coronary arteries form by developmental reprogramming of venous cells
    Kristy Red-Horse
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford, California 94305 5307, USA
    Nature 464:549-53. 2010
    ..Here we show, using histological and clonal analysis in mice and cardiac organ culture, that coronary vessels arise from angiogenic sprouts of the sinus venosus-the vein that returns blood to the embryonic heart...
  28. pmc CT coronary angiography: 256-slice and 320-detector row scanners
    Edward M Hsiao
    Applied Imaging Science Laboratory, Brigham and Women s Hospital Radiology and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Curr Cardiol Rep 12:68-75. 2010
    ..These emerging technical advances and novel applications will continue to change the way we study coronary artery disease beyond detecting luminal stenosis...
  29. pmc Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation
    Azza B el-Remessy
    College of Pharmacy, The University of Georgia, 1120 15th Street, HM 1200, Augusta, GA 30912, USA
    Exp Diabetes Res 2010:247861. 2010
    ..Together, peroxynitrite can suppress eNOS expression via activation of RhoA and hence cause vascular dysfunction...
  30. ncbi Intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction: the INFUSE-AMI randomized trial
    Gregg W Stone
    Columbia University Medical Center and New York Presbyterian Hospital, New York, New York 10022, USA
    JAMA 307:1817-26. 2012
    ..Two strategies proposed to reduce distal embolization and improve outcomes after primary PCI are bolus intracoronary abciximab and manual aspiration thrombectomy...
  31. ncbi Induced pluripotent stem cell (iPSC)-derived Flk-1 progenitor cells engraft, differentiate, and improve heart function in a mouse model of acute myocardial infarction
    Christina Mauritz
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Department of Cardiothoracic, Transplantation and Vascular Surgery, Rebirth Cluster of Excellence, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 32:2634-41. 2011
    ....
  32. ncbi Presence of periodontopathic bacteria in coronary arteries from patients with chronic periodontitis
    Silvia L Marcelino
    Department of Stomatology, University of Sao Paulo, SP, Brazil
    Anaerobe 16:629-32. 2010
    ..Our results indicate a significant association between the presence of Porphyromonas gingivalis and atheromas, and the periodontal bacteria in oral biofilm may find a way to reach arteries...
  33. ncbi A computational study of the interaction between coronary blood flow and myocardial mechanics
    Nicolas P Smith
    Bioengineering Institute, University of Auckland, Auckland 1020, New Zealand
    Physiol Meas 25:863-77. 2004
    ..finite deformation mechanics solutions the regional variation in intramyocardial pressure (IMP) exerted on coronary vessels embedded in the ventricular wall is calculated...
  34. ncbi Virtual histology evaluation of atherosclerosis regression during atorvastatin and ezetimibe administration: HEAVEN study
    Tomas Kovarnik
    2nd Department of Medicine, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Circ J 76:176-83. 2012
    ..There is no study focusing on changes in coronary atherosclerosis during dual lipid-lowering therapy with statin and ezetimibe...
  35. ncbi Human-like atherosclerosis in minipigs: a new model for detection and treatment of vulnerable plaques
    Troels Thim
    Department of Cardiology and Institute of Clinical Medicine, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark
    Dan Med Bull 57:B4161. 2010
    ..The usefulness of this animal model was demonstrated in a study testing an imaging modality aimed at vulnerable plaque detection in humans...
  36. ncbi Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the PREDICTION Study
    Peter H Stone
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 126:172-81. 2012
    ....
  37. ncbi Intracoronary optical coherence tomography and histology at 1 month and 2, 3, and 4 years after implantation of everolimus-eluting bioresorbable vascular scaffolds in a porcine coronary artery model: an attempt to decipher the human optical coherence tomo
    Yoshinobu Onuma
    Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
    Circulation 122:2288-300. 2010
    ..We therefore report OCT findings with corresponding histology in the porcine coronary artery model immediately after and at 28 days and 2, 3, and 4 years after BVS implantation...
  38. ncbi Delayed coverage in malapposed and side-branch struts with respect to well-apposed struts in drug-eluting stents: in vivo assessment with optical coherence tomography
    Juan Luis Gutiérrez-Chico
    Erasmus Medical Centre, Thoraxcenter, Rotterdam, Netherlands
    Circulation 124:612-23. 2011
    ..Whether the neointimal coverage of nonapposed side-branch and ISA struts is delayed with respect to well-apposed struts is unknown...
  39. ncbi Detection of coronary artery anomalies in infants and young children with congenital heart disease by using MR imaging
    Tarinee Tangcharoen
    Division of Imaging Sciences, Guy s and St Thomas Hospital, The Rayne Institute, King s College London, 4th Floor, Lambeth Wing, London SE1 7EH, England
    Radiology 259:240-7. 2011
    ..To evaluate the feasibility and accuracy of magnetic resonance (MR) coronary angiography for the detection of coronary artery anomalies in infants and children by using surgical findings as a reference...
  40. ncbi Cardiac magnetic resonance detection of myocardial scarring in hypertrophic cardiomyopathy: correlation with histopathology and prevalence of ventricular tachycardia
    Deborah H Kwon
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 54:242-9. 2009
    ....
  41. ncbi Reproducibility of coronary Fourier domain optical coherence tomography: quantitative analysis of in vivo stented coronary arteries using three different software packages
    Takayuki Okamura
    Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    EuroIntervention 6:371-9. 2010
    ..We tested the reproducibility of in vivo, intracoronary FD OCT and assessed the influence of different computer-assisted algorithms on quantitative analysis...
  42. pmc Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction
    Si Jin
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th, Richmond, VA 23298, USA
    Arterioscler Thromb Vasc Biol 28:485-90. 2008
    ..The present study tested whether EST stimulates clustering of ceramide-enriched lipid rafts (LRs), which assembles and activates NADPH oxidase to form redox signaling platforms...
  43. pmc Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells
    S W Seto
    Department of Pharmacology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, PR China
    Br J Pharmacol 151:987-97. 2007
    ..We hypothesized that this enzyme exists in different cardiovascular tissues, and simvastatin modulates the vascular iberiotoxin-sensitive Ca2+-activated K(+) (BK(Ca)) channels...
  44. ncbi Novel bioabsorbable salicylate-based polymer as a drug-eluting stent coating
    Refat Jabara
    Saint Joseph s Translational Research Institute, Saint Joseph s Hospital of Atlanta, Atlanta, Georgia 30342, USA
    Catheter Cardiovasc Interv 72:186-94. 2008
    ..Therefore, optimal polymer selection and the use of completely absorbable but biocompatible polymers are expected to minimize these risks...
  45. ncbi Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study
    Gaku Nakazawa
    CVPath Institute, Inc, 19 Firstfield Rd, Gaithersburg, MD 20878, USA
    Circulation 118:1138-45. 2008
    ..Using autopsy data, we evaluated the pathological responses of the stented segment in patients treated with DES for AMI and compared with patients with stable angina...
  46. ncbi Improved survival with radial artery versus vein conduits in coronary bypass surgery with left internal thoracic artery to left anterior descending artery grafting
    Anoar Zacharias
    Division of Cardiovascular Surgery, St Vincent Mercy Medical Center, Toledo, Ohio 43608, USA
    Circulation 109:1489-96. 2004
    ..This grafting also led to increased use of other arterial conduits, of which the radial artery is most popular. Whether radial grafting improves survival beyond that achieved by LITA-LAD alone is not known...
  47. ncbi Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel
    V P Deenadayalu
    Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, Ohio 45435-0927, USA
    Am J Physiol Heart Circ Physiol 281:H1720-7. 2001
    ..This novel mechanism may provide a better understanding of testosterone-induced vasorelaxation reported in recent experimental and early clinical studies...
  48. ncbi Relation between coronary artery calcium and incident chest pain in a community-dwelling screening population
    Allen J Taylor
    Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA
    Am J Cardiol 96:61-3. 2005
    ..Incident chest pain is common and should be examined according to a patient's pretest probability of developing coronary artery disease, without excessive influence of the presence of coronary artery calcium...
  49. ncbi Relation of thoracic aortic and aortic valve calcium to coronary artery calcium and risk assessment
    Nathan D Wong
    Heart Disease Prevention Program, Department of Medicine, University of California, Irvine, California, USA
    Am J Cardiol 92:951-5. 2003
    ....
  50. ncbi Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    FASEB J 17:1183-5. 2003
    ..Thus, a proinflammatory shift in the profile of vascular cytokine expression may contribute to the aging-induced phenotypic changes in coronary arteries, promoting the development of ischemic heart disease in the elderly...
  51. ncbi Radiation dose reduction and coronary assessability of prospective electrocardiogram-gated computed tomography coronary angiography: comparison with retrospective electrocardiogram-gated helical scan
    Takao Maruyama
    Department of Cardiology, Kawasaki Hospital, Kobe, Japan
    J Am Coll Cardiol 52:1450-5. 2008
    ....
  52. ncbi High serum leptin is associated with attenuated coronary vasoreactivity
    Jan Sundell
    Department of Medicine, Turku University, Turku, Finland
    Obes Res 11:776-82. 2003
    ..We examined the association between circulating leptin concentration and coronary vasoreactivity in young obese and nonobese males...
  53. ncbi A preliminary study on the cardioprotection of acupuncture pretreatment in rats with ischemia and reperfusion: involvement of cardiac beta-adrenoceptors
    Junhong Gao
    Department of Physiology, Institute of Acupuncture, China Academy of Chinese Medical Sciences, Beijing 100700, P R China
    J Physiol Sci 56:275-9. 2006
    ..There was no significant cardioprotective effect observed in the EAN group. The results suggest that pretreatment may be a better way to apply acupuncture in the prevention and treatment of coronary heart disease...
  54. ncbi Unreliable assessment of necrotic core by virtual histology intravascular ultrasound in porcine coronary artery disease
    Troels Thim
    The Atherosclerosis Research Unit, Department of Cardiology, Aarhus University Hospital, Brendstrupgaardsvej 100, Skejby, Denmark
    Circ Cardiovasc Imaging 3:384-91. 2010
    ..We tested for correlation between VH IVUS necrotic core size and necrotic core size by histology in porcine coronary arteries with human-like coronary disease...
  55. pmc Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy
    Christian Templin
    Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Eur Heart J 31:1792-801. 2010
    ..Hence, the present study was designed to evaluate the capacity of coronary OFDI by electron (SEM) and light microscopy (LM) analysis to detect and evaluate stent strut coverage in a porcine model...
  56. ncbi Evaluation in 3 months duration of neointimal coverage after zotarolimus-eluting stent implantation by optical coherence tomography: the ENDEAVOR OCT trial
    Jung Sun Kim
    Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea
    JACC Cardiovasc Interv 2:1240-7. 2009
    ..We performed this study to investigate the vascular response in early period after zotarolimus-eluting stent (ZES) (Endeavor Sprint, Medtronic CardioVascular, Minneapolis, Minnesota) implantation...
  57. ncbi Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model
    T Suzuki
    Stanford University Medical Center, Stanford, California, USA
    Circulation 104:1188-93. 2001
    ..CONCLUSIONS: Stent-based delivery of SRL via a nonerodable polymer matrix is feasible and effectively reduces in-stent neointimal hyperplasia by inhibiting cellular proliferation...
  58. ncbi Transcoronary transplantation of progenitor cells after myocardial infarction
    Birgit Assmus
    Division of Cardiology and Molecular Cardiology, Department of Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1222-32. 2006
    ..The effects of cell transplantation in patients with healed myocardial infarction are unknown...
  59. ncbi In vivo volumetric analysis of coronary stent using optical coherence tomography with a novel balloon occlusion-flushing catheter: a comparison with intravascular ultrasound
    Yoshiaki Kawase
    Cardiology Laboratory for Integrative Physiology and Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 31:1343-9. 2005
    ..Although OCT underestimates the stent strut thickness, motorized pullback OCT imaging with the occlusion catheter can provide appropriate in-stent images in the porcine coronary arteries...
  60. ncbi Multidetector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries
    Konstantin Nikolaou
    Department of Clinical Radiology, University of Munich, Grosshadern Campus, Marchioninistr 15, 81377 Munich, Germany
    Atherosclerosis 174:243-52. 2004
    ..Using the information presented in this study, in vivo coronary artery wall imaging using MDCT as well as MRI could be facilitated and supported for future investigations on this subject...
  61. ncbi A new imaging technique to study 3-D plaque and shear stress distribution in human coronary artery bifurcations in vivo
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, Ee2322, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Biomech 40:2349-57. 2007
    ..Both are related to blood flow-induced shear stress (SS). We present a new approach to generate 3-D reconstructions of coronary artery bifurcations in vivo and investigate the relationship between SS, wall thickness (WT) and remodeling...
  62. ncbi The coronary artery calcium score and stress myocardial perfusion imaging provide independent and complementary prediction of cardiac risk
    Su Min Chang
    Methodist DeBakey Heart and Vascular Center and The Methodist Hospital Research Institute, The Methodist Hospital, Houston, Texas, USA
    J Am Coll Cardiol 54:1872-82. 2009
    ..This study sought to examine the relationship between coronary artery calcium score (CACS) and single-photon emission computed tomography (SPECT) results for predicting the short- and long-term risk of cardiac events...
  63. ncbi Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    Atherosclerosis 186:20-8. 2006
    ..This study identified genes not previously known to be regulated by VDR, providing insight into understanding the role of VDR on regulating smooth muscle cell growth, thrombogenicity, fibrinolysis and endothelial regeneration...
  64. ncbi Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study
    Pavan K Cheruvu
    Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 50:940-9. 2007
    ..Our purpose was to quantify the frequency and distribution of suspected vulnerable lesions, defined as thin-capped fibroatheroma (TCFA) and ruptured plaque, in human coronary artery autopsy specimens...
  65. ncbi Comparison of virtual histology to intravascular ultrasound of culprit coronary lesions in acute coronary syndrome and target coronary lesions in stable angina pectoris
    Myeong Ki Hong
    Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Am J Cardiol 100:953-9. 2007
    ..In conclusion, culprit lesions in patients with ACS were more unstable and had greater amounts of necrotic core and smaller amounts of fibrofatty plaque compared with target lesions in patients with SAP...
  66. pmc A novel feature-tracking echocardiographic method for the quantitation of regional myocardial function: validation in an animal model of ischemia-reperfusion
    Bahar Pirat
    Methodist DeBakey Heart Center Echocardiography Laboratory and Baylor College of Medicine, Division of Cardiology, Houston, Texas 77030, USA
    J Am Coll Cardiol 51:651-9. 2008
    ..The aim of this study was to validate a novel, angle-independent, feature-tracking method for the echocardiographic quantitation of regional function...
  67. ncbi Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study
    Peter H Stone
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:438-44. 2003
    ..The endothelium controls local arterial responses by transduction of shear stress. Characterization of endothelial shear stress (ESS) may allow for prediction of progression of atherosclerosis and in-stent restenosis...
  68. ncbi Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries
    Wendy W Batenburg
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    Circulation 109:2296-301. 2004
    ..In contrast, AT2 receptor-mediated vasodilation could not be observed in large human coronary arteries. We studied Ang II-induced vasodilation of human coronary microarteries (HCMAs)...
  69. ncbi Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements
    Brian W McCrindle
    University of Toronto, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Circulation 116:174-9. 2007
    ..Analysis of serial normalized artery measurements may reveal a broader continuous spectrum of involvement and different risk factors...
  70. ncbi Measurement of the thickness of the fibrous cap by optical coherence tomography
    Teruyoshi Kume
    Department of Cardiology, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Am Heart J 152:755.e1-4. 2006
    ..The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to measure the thickness of the fibrous cap within lipid-rich plaque...
  71. ncbi Comparing coronary artery calcium and thoracic aorta calcium for prediction of all-cause mortality and cardiovascular events on low-dose non-gated computed tomography in a high-risk population of heavy smokers
    Peter C Jacobs
    Julius Center for Health Sciences and Primary Care, Department of Radiology, University Medical Center Utrecht, Netherlands
    Atherosclerosis 209:455-62. 2010
    ..This study compared CAC and TAC as independent predictors of all-cause mortality and cardiovascular events in a population of heavy smokers using low-dose, non-gated CT...
  72. ncbi Double-oblique free-breathing high resolution three-dimensional coronary magnetic resonance angiography
    M Stuber
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 34:524-31. 1999
    ..The goal of the present study was to develop a strategy for three-dimensional (3D) volume acquisition along the major axes of the coronary arteries...
  73. ncbi A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization
    Marie Claude Morice
    Institut Cardiovasculaire Paris Sud, Massy, France
    N Engl J Med 346:1773-80. 2002
    ..Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared a sirolimus-eluting stent with a standard uncoated stent in patients with angina pectoris...
  74. ncbi Treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter
    Bruno Scheller
    Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    N Engl J Med 355:2113-24. 2006
    ..Treatment of coronary in-stent restenosis is hampered by a high incidence of recurrent in-stent restenosis. We assessed the efficacy and safety of a paclitaxel-coated balloon in this setting...
  75. pmc A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps
    Yuliya Vengrenyuk
    Department of Biomedical Engineering, City College of New York, Convent Avenue and 138th Street, New York, NY 10031, USA
    Proc Natl Acad Sci U S A 103:14678-83. 2006
    ..The most likely candidates for the inclusions are either calcified macrophages or smooth muscle cells that have undergone apoptosis...
  76. ncbi Perivascular inflammation after balloon angioplasty of porcine coronary arteries
    E Okamoto
    Winship Cancer Institute, Department of Surgery, Emory University, Atlanta, GA, USA
    Circulation 104:2228-35. 2001
    ....
  77. ncbi Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
    V Schachinger
    Department of Internal Medicine IV, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    Circulation 101:1899-906. 2000
    ..Therefore, we prospectively investigated whether coronary endothelial dysfunction predicts disease progression and cardiovascular event rates...
  78. ncbi Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response
    George P Sorescu
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 278:31128-35. 2003
    ..We suggest that BMP4 is a mechanosensitive, inflammatory factor playing a critical role in early steps of atherogenesis in the lesion-prone areas...
  79. ncbi Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries?
    Kerstin Wustmann
    Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland
    Circulation 107:2213-20. 2003
    ..Such preformed coronary collateral vessels could form the basis for subsequently developing protective natural bypasses in the presence of coronary artery disease...
  80. ncbi Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
    Manuel D Cerqueira
    American Society of Nuclear Cardiology, USA
    Circulation 105:539-42. 2002
  81. ncbi Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions
    Antonio Colombo
    EMO Centro Cuore Columbus, Milan, Italy
    Circulation 109:1244-9. 2004
    ..A sirolimus-eluting stent (Cypher, Cordis Corp) has been reported to markedly decrease restenosis in selected lesions; higher-risk lesions, including coronary bifurcations, have not been studied...
  82. ncbi Shape-driven segmentation of the arterial wall in intravascular ultrasound images
    Gozde Unal
    Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey
    IEEE Trans Inf Technol Biomed 12:335-47. 2008
    ..All these features greatly enhance our segmentation method. The tests of our algorithm on a large dataset demonstrate the effectiveness of our approach...
  83. ncbi A randomized optical coherence tomography study of coronary stent strut coverage and luminal protrusion with rapamycin-eluting stents
    Philip Moore
    Royal Brompton and Harefield NHS Trust, Middlesex, United Kingdom
    JACC Cardiovasc Interv 2:437-44. 2009
    ..We used optical coherence tomography, which has a resolution of <20 microm, to analyze thin layers of neointima in rapamycin-eluting coronary stents...
  84. ncbi Relationship between cardiovascular autonomic neuropathy and coronary artery calcification in patients with type 2 diabetes
    Seong Su Moon
    Department of Endocrinology and Metabolism, Kyungpook National University Hospital, Jungu, Daegu, Korea
    Endocr J 57:445-54. 2010
    ..This may help to explain the excess cardiovascular mortality seen in diabetic patients with CAN...
  85. pmc Role of TNF-alpha-induced reactive oxygen species in endothelial dysfunction during reperfusion injury
    Xue Gao
    Department of Internal Medicine, Dalton Cardiovascular Research Center, University of Missouri Columbia, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 295:H2242-9. 2008
    ..We conclude that myocardial ischemia initiates TNF-alpha expression, which induces vascular oxidative stress, independent of neutrophil activation, and leads to coronary endothelial dysfunction...
  86. ncbi Severe coronary tortuosity or myocardial bridging in patients with chest pain, normal coronary arteries, and reversible myocardial perfusion defects
    Nicola Gaibazzi
    Division of Cardiology, Parma University Hospital, Italy
    Am J Cardiol 108:973-8. 2011
    ....
  87. ncbi Optical coherence tomography
    E Regar
    Department of Cardiology, Thoraxcentre, Erasmus Medical Centre Rotterdam, Bd 406, Dr Molewaterplein 40, NL 3015 GD Rotterdam, The Netherlands
    Cardiovasc Radiat Med 4:198-204. 2003
    ..The rationale for intravascular application of OCT is its potential for in vivo visualisation of the coronary artery microstructure...
  88. pmc Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture
    Jacques Ohayon
    National Heart, Lung and Blood Institute, NIH, Bldg 10, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 295:H717-27. 2008
    ..This study demonstrates that plaque instability is to be viewed not as a consequence of fibrous cap thickness alone but rather as a combination of cap thickness, necrotic core thickness, and the arterial remodeling index...
  89. pmc Feasibility of perfusion cardiovascular magnetic resonance in paediatric patients
    Emanuela R Valsangiacomo Buechel
    University Children s Hospital Zurich, Division of Paediatric Cardiology, 8032 Zurich, Switzerland
    J Cardiovasc Magn Reson 11:51. 2009
    ..As coronary artery disease may also occur during childhood in some specific conditions, we sought to assess the feasibility and accuracy of perfusion cardiovascular magnetic resonance (CMR) in paediatric patients...
  90. pmc Drug-eluting stents in preclinical studies: updated consensus recommendations for preclinical evaluation
    Robert S Schwartz
    Minneapolis Heart Institute and Foundation, 920 E 28th Street, Suite 600, Minneapolis, MN 55407
    Circ Cardiovasc Interv 1:143-53. 2008
    ..This expert consensus document is consistent with the Food and Drug Administration guidance. The dynamic nature of this field mandates future modifications and additions that will be added over time...
  91. ncbi Potential and limitations of wave intensity analysis in coronary arteries
    Maria Siebes
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Med Biol Eng Comput 47:233-9. 2009
    ..of pulse wave velocity at the point of measurement, which at present cannot accurately be determined in human coronary vessels. This prompted us to study the sensitivity of wave separation to variations in wave speed...
  92. ncbi Pattern of arterial calcification in patients with systemic lupus erythematosus
    Kai Hang Yiu
    Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong
    J Rheumatol 36:2212-7. 2009
    ..Multidetector computed tomography (MDCT) measured arterial calcium score (CS) reflecting underlying atherosclerosis and is closely associated with cardiovascular events...
  93. ncbi Functional and structural adaptations of coronary microvessels distal to a chronic coronary artery stenosis
    Oana Sorop
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands
    Circ Res 102:795-803. 2008
    ..These structural and functional alterations may aggravate flow abnormalities distal to a chronic coronary artery stenosis...
  94. ncbi Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia
    Markus Rehm
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Circulation 116:1896-906. 2007
    ..As already demonstrated, this structure plays a key role in the regulation of inflammation and vascular permeability...
  95. ncbi Embryonic development of the proepicardium and coronary vessels
    Anna Ratajska
    Department of Pathological Anatomy, Medical University of Warsaw, Poland
    Int J Dev Biol 52:229-36. 2008
    ..The coronary artery wall matures first before cardiac veins. Maturity of the vessel wall is demonstrated by the specific shape of the internal surface of the vascular wall...
  96. ncbi Free-breathing 3D coronary MRA: the impact of "isotropic" image resolution
    R M Botnar
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Magn Reson Imaging 11:389-93. 2000
    ..coronary magnetic resonance angiography (MRA) usually provides only one or two views of the major coronary vessels. A coronary MRA approach that allowed for reconstruction of arbitrary isotropic orientations might therefore ..
  97. ncbi Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow
    Shu Ichi Saitoh
    Department of Physiology, LSU Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Arterioscler Thromb Vasc Biol 26:2614-21. 2006
    ..Accordingly, we measured O2*- and H2O2 production by isolated cardiac myocytes, determined the role of mitochondrial electron transport in the production of these species, and determined the vasoactive properties of the produced H2O2...
  98. ncbi Free-breathing whole-heart coronary MRA with 3D radial SSFP and self-navigated image reconstruction
    C Stehning
    Institute of Biomedical Engineering, Karlsruhe, Germany
    Magn Reson Med 54:476-80. 2005
    ..Image quality was improved in phantom studies using self-navigation, while equivalent results were obtained with both techniques in preliminary in vivo studies...
  99. ncbi Correction for heart rate variability improves coronary magnetic resonance angiography
    Tim Leiner
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Magn Reson Imaging 22:577-82. 2005
    ..To address degradation of coronary MR angiography (MRA) image quality due to heart rate variability (HRV)-associated variations in coronary artery position and motion...
  100. ncbi Cell type-specific localization of human cardiac S1P receptors
    David Mazurais
    Laboratoire GlaxoSmithKline, Unité de Biologie Cardiovasculaire, Saint Grégoire, France
    J Histochem Cytochem 50:661-70. 2002
    ..The present results provide new insight into the expression pattern of S1P receptors in human cardiovascular tissues, indicating a differential pattern of expression for these receptors in human vessels...
  101. ncbi Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy
    Takashi Kubo
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    J Am Coll Cardiol 50:933-9. 2007
    ....

Research Grants62

  1. EICOSANOID SYNTHESIS AND FUNCTION IN CORONARY VESSELS
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..These studies will provide specific pharmacological tools to study the role of EETs as EDHFs and provide new insights into the vascular action of the EETs. ..
  2. Emerging Functions of Mitochondrial Fission in Postischemic Endothelial Cells
    BARBARA RITA ALEVRIADOU; Fiscal Year: 2012
    ..The decline in bioavailable nitric oxide (NO) impairs the EC-dependent dilation in coronary vessels. NO, both by itself and via peroxynitrite formation, is known to promote mitochondrial O27- production...
  3. Flow-induced coronary vasospasm in diabetic patients
    Zsolt Bagi; Fiscal Year: 2013
    ..via inducing phospholipase A2 and arachidonic acid release leads to enhanced production of thromboxane A2 in coronary vessels of T2-DM patients...
  4. Periodontal Pathogens and Cardiovascular Disease
    KESAVALU NAIDU LAKSHMYYA; Fiscal Year: 2013
    ..intermedia, Fusobacterium nucleatum, and Eikenella corrodens) in atherosclerotic lesions of aortic tissue, coronary vessels, and carotid artery...
  5. IGF-1, Gender, Heart Failure and Longevity: A Paradigm Shift
    Piero Anversa; Fiscal Year: 2010
    ..is a stem cell myopathy in which a defective stem cell compartment conditions aging and death of myocytes and coronary vessels, which are delayed in the female heart...
  6. Elucidating the mechanisms of venous reprogramming during coronary development
    MARY K RED-HORSE; Fiscal Year: 2011
    ..b>Coronary vessels begin as venous sprouts of the sinus venosus that de-differentiate as they migrate onto and invade the heart...
  7. Effects of K+ Accumulation/Depletion in the Heart
    Guy Salama; Fiscal Year: 2013
    ..K+]a elevation will be correlated with coronary vessels, fiber orientation and the origins of premature impulses...
  8. Coronary Vasculature Progenitor Cell in Human Ischemic Heart Failure
    Annarosa Leri; Fiscal Year: 2012
    ..of an ischemic myopathy chronically, we need to identify a PC capable of restoring the integrity of injured coronary vessels and/or creating de novo conductive coronary arteries and their distal branches...
  9. Disease Mechanisms in Sleep Apnea
    Virend K Somers; Fiscal Year: 2013
    ..vessel endothelial dysfunction is associated with endothelial dysfunction in other vessels, including in the coronary vessels and in the microvasculature...
  10. Regulation of coronary vascular development by differential tissue hypoxia
    Michiko Watanabe; Fiscal Year: 2010
    ..inducible factor -1a (HIF-1a) nuclear localization in the developing heart at specific sites where major coronary vessels will develop...
  11. Elucidating the mechanisms of venous reprogramming during coronary development
    MARY K RED-HORSE; Fiscal Year: 2013
    ..b>Coronary vessels begin as venous sprouts of the sinus venosus that de-differentiate as they migrate onto and invade the heart...
  12. Telomeric Shortening, p53 and miR-34a Condition Senescence of Cardiac Progenitors
    Annarosa Leri; Fiscal Year: 2013
    ..by applicant): The recognition that the heart possesses a stem cell compartment that forms myocytes and coronary vessels raises the possibility that alterations in number and/or function of cardiac progenitor cells (CPCs) ..
  13. Origins and Patterning of the Epicardium
    NATHALIA SARAH GLICKMAN HOLTZMAN; Fiscal Year: 2010
    ..In addition, the epicardial cells populate and pattern the coronary vessels that are required to oxygenate the heart muscle...
  14. Ancillary Investigation of Mental Stress Biomarkers in Coronary Heart Disease
    Andrew Sherwood; Fiscal Year: 2013
    ..resting conditions, and further compromise of this critical vascular regulatory mechanism, especially in the coronary vessels, may provoke mental stress ischemia and increase the risk for cardiac events...
  15. Characterization of Cell-Based Therapy for Congenital Heart Patients
    Sunjay Kaushal; Fiscal Year: 2013
    ..it is superior, inferior, or equal to bone marrow-derived cells for the regeneration of cardiomyocytes and coronary vessels in the doxorubicin- induced cardiomyopathy model...
  16. VENTRICULAR FIBRILLATION AND ITS ALTERATION BY PACING
    Raymond E Ideker; Fiscal Year: 2010
    ..than in the remainder of the ventricles, (2) conduction block occurs more frequently along the paths of coronary vessels or in regions with a high spatial dispersion of refractoriness, and (3) cardiac disease and drugs alter the ..
  17. MECHANISM OF CORONARY ENDOTHELIUM MEDIATED VASODILATION
    Pin Lan Li; Fiscal Year: 2000
    ..factor, nitric oxide (NO) have been reported to activate K+ channel in vascular smooth muscle and dilate coronary vessels. However, the mechanism by which EETs and NO activate K+ channels remains unknown...
  18. MYOCARDIAL ISCHEMIA INDUCED BY INHALED ANESTHETICS
    CHARLES BUFFINGTON; Fiscal Year: 1993
    ..that halothane and isoflurane, the major inhalation anesthetics in use today, differ in their effects on coronary vessels and platelets and thus differ in their tendency to cause or worsen ischemia due to thrombus formation or ..
  19. CORONARY BLOOD VESSELS AND HEART DISEASE
    Thomas Sato; Fiscal Year: 2004
    ..Normal morphogenesis and physiological functions of coronary vessels are critically required for the physiological functions of the heart...
  20. An Endothelial Progenitor Cell-Specific Nanofibrous Vascular Graft
    Lisa Fitzgerald; Fiscal Year: 2009
    ..arterial graft clinically accepted for use in the peripheral circulation (below knee popliteal) and coronary vessels, which affects over 500,000 patients each year...
  21. FACTORS THAT REGULATE COLLATERAL PERFUSION
    David Harrison; Fiscal Year: 1993
    ..These will be coupled with parallel studies of larger epicardial coronary vessels studied in isolated organ chambers...
  22. Accelerated Repair of Vascular Injury in Diabetes by TGF-beta Modified Stem Cells
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..Our focus is to demonstrate proof of principle that adult HSC can be effectively used to repair infarcted coronary vessels and eventually greatly improve the quality and duration of these patient's lives.
  23. CORONARY VASCULAR RESPONSE TO ISCHEMIA
    ROBERT BACHE; Fiscal Year: 2007
    The studies in this proposal will examine responses of the coronary vessels to myocardial ischemia, and determine whether alterations of nitric oxide (NO) or superoxide (02-) influence vascular or myocardial responses in ischemic regions...
  24. CARDIOVASCULAR ADAPTATIONS TO RENOVASCULAR HYPERTENSION
    PATRICIA GWIRTZ; Fiscal Year: 2001
    ..These alterations would cause exaggerated vasoconstrictor reflex influences on the coronary vessels and a reduced ability to increase coronary blood flow...
  25. COMPUTER ASSISTED MAPPING OF VENTRICULAR FIBRILLATION
    Raymond Ideker; Fiscal Year: 2009
    ..Specific Aim 3: Ascertain the role of coronary vessels in causing block and reentry during VF...
  26. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
    ..This hypothesis will be tested by crossing the Brown Norway with Dahl S rat. The isolated heart model and coronary vessels will be used to facilitate discrete, well-controlled investigations of susceptibility to ischemia with and ..
  27. ANTIOXIDANTS AND ENDOTHELIAL FUNCTION IN DIABETES
    Mark Creager; Fiscal Year: 2000
    ..administration of the antioxidants, vitamin C and vitamin E, on vasodilator reactivity in peripheral and coronary vessels of patients with diabetes mellitus (both IDDM and NIDDM) and healthy, age-matched control subjects...
  28. Postmenopause CHD risk: Platelet genes & hormone therapy
    Paul Bray; Fiscal Year: 2006
    ..of MI and stroke, these findings raise questions about the effect of HRT on platelet thrombus formation in coronary vessels. Our published and preliminary data show that 1) female platelets are hyperreactive compared to male ..
  29. MOLECULAR/CELLULAR BIOLOGY OF CARDIOMYOCTE DEVELOPMENT
    DONALD FISCHMAN; Fiscal Year: 2000
    ..retroviral vectors which have been used to trace the lineage of cardiomyocytes, precursors of the coronary vessels, and the cardiac conduction system; e) proposed plausible models to explain the morphogenesis of the ..
  30. Nitric oxide and superoxide effects on the failing heart
    Yingjie Chen; Fiscal Year: 2006
    ..Additional studies will determine whether mRNA and protein expression and activity for eNOS, nNOS, iNOS, CuZn-SOD, Mn-SOD and Ec-SOD are altered in coronary vessels and myocardium by the presence of CHF.
  31. A Prospective Study of Young Adults with ESRD
    Rulan Parekh; Fiscal Year: 2004
    ..of the carotid vessels to assess carotid intimal medial wall thickness, and ECG-triggered helical CT of the coronary vessels to assess coronary calcification...
  32. HETEROGENEITY OF CORONARY ARTERY VASOMOTION
    Frederick Cobb; Fiscal Year: 1993
    ..mechanisms in each segment by characterizing responses of proximal conductance and distal resistance coronary vessels to endogenous and exogenous vasoactive agents...
  33. Regulation of Coronary Vessel Assembly and Growth
    Robert Tomanek; Fiscal Year: 2007
    ..which regulate these events, 2) are the first to address bone marrow-derived cells as contributors to the coronary vessels during development, and 3) explore stretch as a growth associated stimulus for myocardial vascularization...
  34. ANTIFIBRILLATORY MECHANISMS OF INTRAPERICARDIAL AGENTS
    RICHARD VERRIER; Fiscal Year: 2004
    ..has the intrinsic advantage of delivering high concentrations of compounds to intracardiac nerves, coronary vessels and myocardium while minimizing adverse side effects of systemic drug administration...
  35. Methods for MR Guided Interventions in Coronary Vessels
    Nikolaos Tsekos; Fiscal Year: 2006
    DESCRIPTION (provided by applicant):Methods for MRI Guided Interventions in Coronary Vessels. MRI can provide the means to assess both vascular and soft tissue morphology and function...
  36. MOLECULAR AND FUNCTIONAL IMPACT OF CARDIAC FIBROSIS
    Karen Vikstrom; Fiscal Year: 2003
    ..features of human HCM, including myocellular disarray, fibrosis and the presence of abnormal small coronary vessels. In this model, females continue to hypertrophy while males progress from a hypertrophied to a dilated ..
  37. In-site Measurement of Plaque Biomechanical Properties
    Brett Bouma; Fiscal Year: 2005
    ..and apply an optical coherence tomography (OCT) imaging method for assessing stress, strain and compliance in coronary vessels in vivo...
  38. PRESSURE AND FLOW INDUCED REMODELING OF CORONARY VESSELS
    Ghassan Kassab; Fiscal Year: 2002
    ....
  39. Molecular Regulation of Coronary Vessel Development
    David Bader; Fiscal Year: 2005
    Development of the coronary vessels is one of the most critical events in the formation of a functional heart...
  40. SCOR IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
    DAVID HAJJAR; Fiscal Year: 2001
    ..in angiogenesis, mitogenic factors in the formation of the coronary network and patterning of coronary vessels, and the molecular deficiencies associated with growth control of atherosclerotic cells using dominant-..
  41. Effects of HAART drugs on endothelial dysfunction of pu*
    Changyi Chen; Fiscal Year: 2009
    ..abstract_text> ..
  42. Tissue engineering of small diameter vascular graft
    Changyi Chen; Fiscal Year: 2006
    ..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
  43. ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSION
    Changyi Chen; Fiscal Year: 2002
    ....
  44. Molecular Surgeon Symposium on Vascular Injury, Repair
    Changyi Chen; Fiscal Year: 2005
    ..A pre-approved letter for acceptance of submission of this application from NIH/NHLBI is included. ..
  45. HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIA
    Changyi Chen; Fiscal Year: 2002
    ....
  46. A Validated Micro-Structural Mechanical Model of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ....
  47. Pressure and Flow-Induced Remodeling of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ..The long-term goal of this research is to develop optimal therapies to restore the oxidative balance in CAD. ..
  48. HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Changyi Chen; Fiscal Year: 2004
    ..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
  49. Hemodynamic forces regulate BMPs in coronary arteries
    Zoltan Ungvari; Fiscal Year: 2009
    ..abstract_text> ..
  50. Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic Cancer
    Changyi Chen; Fiscal Year: 2008
    ..Furthermore, invited speakers are encouraged to submit manuscripts related to their presentations to "World Journal of Surgery" for consideration of publications. [unreadable] [unreadable] [unreadable]..
  51. Effects of HIV Protease Inhibitors of Endothelial Barrie
    Changyi Chen; Fiscal Year: 2005
    ..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
  52. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  53. Mechanisms of Cardioprotection
    Roberto Bolli; Fiscal Year: 2007
    ....
  54. OXYGEN RADICALS AND POSTISCHEMIC DYSFUNCTION
    Roberto Bolli; Fiscal Year: 2002
    ..Elucidation of the mechanism of late PC should facilitate the development of drugs that duplicate its powerful cardioprotective effects. ..
  55. Hematopoietic Stem Cell Therapy for Myocardial Regeneration
    Roberto Bolli; Fiscal Year: 2007
    ..The results may eventually lead to the development of novel therapeutic strategies in patients with ischemic heart disease. ..
  56. Highly Automated Analysis of 4-D Cardiovascular MR Data
    Milan Sonka; Fiscal Year: 2006
    ..The relationship between disease status, standard measures of ventricular function and aortic size, and novel quantitative indices will be assessed. ..
  57. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2007
    ..unreadable]..
  58. SIMULATION RESOURCE IN CIRCULATORY MASS TRANSPORT
    James Bassingthwaighte; Fiscal Year: 2006
    ..Section D.IV. provides core support for software development, simulation and modeling analysis, training, and the dissemination of NSR deliverables. ..
  59. DNA Methylation Profiles in a Polygenic Mouse Model of Diet-Induced Obesity
    Jan Bressler; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Mechanisms of Nural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2010
    ..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..
  61. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  62. Endothelial Deformation and Coronary Arteriolar Function
    Dong Sun; Fiscal Year: 2006
    ....