circle of willis

Summary

Summary: A polygonal anastomosis at the base of the brain formed by the internal carotid (CAROTID ARTERY, INTERNAL), proximal parts of the anterior, middle, and posterior cerebral arteries (ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY), the anterior communicating artery and the posterior communicating arteries.

Top Publications

  1. ncbi Magnetic resonance angiographic evidence of sex-linked variations in the circle of willis and the occurrence of cerebral aneurysms
    Toru Horikoshi
    Department of Neurosurgery, Yamanashi Medical University, Akiyama Neurosurgical Clinic, Japan
    J Neurosurg 96:697-703. 2002
  2. ncbi Circle of Willis at CT angiography: dose reduction and image quality--reducing tube voltage and increasing tube current settings
    Annet Waaijer
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Radiology 242:832-9. 2007
  3. ncbi Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows
    J Alastruey
    Department of Aeronautics, South Kensington Campus, Imperial College London, SW7 2AZ, UK
    J Biomech 40:1794-805. 2007
  4. ncbi The influence of contrast agent injection on physiological flow in the circle of Willis
    G Mulder
    Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
    Med Eng Phys 33:195-203. 2011
  5. ncbi Distribution of cerebral blood flow in the circle of Willis
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, PO Box 85500, Hp E 01 132, 3508 GA Utrecht, The Netherlands
    Radiology 235:184-9. 2005
  6. ncbi Computation of hemodynamics in the circle of Willis
    Martin Sandve Alnaes
    Simula Research Laboratory, Oslo, Norway
    Stroke 38:2500-5. 2007
  7. ncbi CT angiography of the circle of Willis and intracranial internal carotid arteries: maximum intensity projection with matched mask bone elimination-feasibility study
    H W Venema
    Departments of Radiology, and Medical Physics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Radiology 218:893-8. 2001
  8. pmc Cervical carotid and circle of willis arterial anatomy of macaque monkeys: a comparative anatomy study
    Nishant Kumar
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anat Rec (Hoboken) 292:976-84. 2009
  9. ncbi Absent collateral function of the circle of Willis as risk factor for ischemic stroke
    A W J Hoksbergen
    Department of Neurology, University Medical School, Debrecen, Hungary
    Cerebrovasc Dis 16:191-8. 2003
  10. ncbi Migraine and circle of Willis anomalies
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, United States
    Med Hypotheses 70:860-5. 2008

Research Grants

  1. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
  2. Epidemiology of Aging and Dementia-Autopsy Research
    LON RAY WHITE; Fiscal Year: 2010
  3. ANGIOPLASTY IN ANEURYSMAL SUBARACHNOID HEMORRHAGE
    J Muizelaar; Fiscal Year: 2005
  4. HUMAN BRAIN FUNCTION IN INDUCED CEREBRAL HYPOPERFUSION
    RANDOLPH MARSHALL; Fiscal Year: 2001
  5. Image-guided treatment planning for neuro-interventions
    Kenneth Hoffmann; Fiscal Year: 2006
  6. Epidemiology of Aging and Dementia-Autopsy Research
    Lon White; Fiscal Year: 2007
  7. PEROXYNITRITE MEDIATED MECHANISMS IN CEREBRAL ISCHEMIA
    WILLIAM CHILIAN; Fiscal Year: 2001
  8. FLUID DYNAMICS IN TRANSPARENT NATURAL BLOOD VESSELS
    Takeshi Karino; Fiscal Year: 1990
  9. Trigeminal Neuralgia Association 5th National Conference
    Albert Rhoton; Fiscal Year: 2005
  10. BOEC in Biology
    Robert Hebbel; Fiscal Year: 2005

Detail Information

Publications237 found, 100 shown here

  1. ncbi Magnetic resonance angiographic evidence of sex-linked variations in the circle of willis and the occurrence of cerebral aneurysms
    Toru Horikoshi
    Department of Neurosurgery, Yamanashi Medical University, Akiyama Neurosurgical Clinic, Japan
    J Neurosurg 96:697-703. 2002
    In this study the authors investigated the relationship between variations in the circle of Willis observed on magnetic resonance (MR) angiograms and locations of cerebral aneurysms, and evaluated the risk of aneurysm formation.
  2. ncbi Circle of Willis at CT angiography: dose reduction and image quality--reducing tube voltage and increasing tube current settings
    Annet Waaijer
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Radiology 242:832-9. 2007
    To prospectively assess the effects of lower tube voltage and various effective tube currents on image quality for computed tomographic (CT) angiography of the circle of Willis.
  3. ncbi Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows
    J Alastruey
    Department of Aeronautics, South Kensington Campus, Imperial College London, SW7 2AZ, UK
    J Biomech 40:1794-805. 2007
    Blood flow in the circle of Willis (CoW) is modelled using the 1-D equations of pressure and flow wave propagation in compliant vessels. The model starts at the left ventricle and includes the largest arteries that supply the CoW...
  4. ncbi The influence of contrast agent injection on physiological flow in the circle of Willis
    G Mulder
    Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
    Med Eng Phys 33:195-203. 2011
    ..cycle, the response does vary with the location within the cerebral circulation and the geometry of the circle of Willis. At the injection site, the injection partly suppresses the incoming blood flow, such that the distal flow is ..
  5. ncbi Distribution of cerebral blood flow in the circle of Willis
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, PO Box 85500, Hp E 01 132, 3508 GA Utrecht, The Netherlands
    Radiology 235:184-9. 2005
    To prospectively determine the effect of anatomic variations in the circle of Willis on volume flow in the internal carotid arteries (ICAs) and basilar artery (BA).
  6. ncbi Computation of hemodynamics in the circle of Willis
    Martin Sandve Alnaes
    Simula Research Laboratory, Oslo, Norway
    Stroke 38:2500-5. 2007
    ..We aimed to develop a computational fluid dynamics simulator for flow in the complete circle of Willis to study the impact of variations in vessel radii and bifurcation angles on WSS and pressure on vessel walls.
  7. ncbi CT angiography of the circle of Willis and intracranial internal carotid arteries: maximum intensity projection with matched mask bone elimination-feasibility study
    H W Venema
    Departments of Radiology, and Medical Physics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Radiology 218:893-8. 2001
    ..This method is an effective means to remove bone from CT angiographic images with only a slight increase in radiation dose...
  8. pmc Cervical carotid and circle of willis arterial anatomy of macaque monkeys: a comparative anatomy study
    Nishant Kumar
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anat Rec (Hoboken) 292:976-84. 2009
    ..The ICA is similar in course to that of the human. The anterior circle of Willis was intact in all monkeys in our study...
  9. ncbi Absent collateral function of the circle of Willis as risk factor for ischemic stroke
    A W J Hoksbergen
    Department of Neurology, University Medical School, Debrecen, Hungary
    Cerebrovasc Dis 16:191-8. 2003
    Autopsy studies show a higher prevalence of circle of Willis anomalies in brains with signs of ischemic infarction...
  10. ncbi Migraine and circle of Willis anomalies
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, United States
    Med Hypotheses 70:860-5. 2008
    ..The circle of Willis is a major source of collateral blood flow supply in the human brain, and developmental morphologic variants ..
  11. ncbi Relationship between circle of Willis morphology on 3D time-of-flight MR angiograms and transient ischemia during vascular clamping of the internal carotid artery during carotid endarterectomy
    Jeong Hyun Lee
    Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    AJNR Am J Neuroradiol 25:558-64. 2004
    ..We investigated whether circle of Willis morphology on 3D time-of-flight (TOF) MR angiograms can reliably predict transient ischemia during vascular ..
  12. ncbi Discrepancy rates of on-call radiology residents' interpretations of CT angiography studies of the neck and circle of Willis
    Russell E Meyer
    Department of Radiology, Fletcher Allen Health Care, University of Vermont School of Medicine, 111 Colchester Ave, Burlington, VT 05401, USA
    AJR Am J Roentgenol 193:527-32. 2009
    The purpose of our study was to determine the discrepancy rates of radiology residents' interpretations of emergent CT angiography (CTA) studies of the neck and circle of Willis and to assess any adverse clinical outcomes.
  13. ncbi The supratentorial arteries
    Albert L Rhoton
    Department of Neurological Surgery, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610 0265, USA
    Neurosurgery 51:S53-120. 2002
  14. ncbi Flow diverters at and beyond the level of the circle of willis for the treatment of intracranial aneurysms
    Silvia Pistocchi
    Service de Neuroradiologie Interventionnelle, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild, 25 29 rue Manin, 75940 Paris Cedex 19, France
    Stroke 43:1032-8. 2012
    ..Initial reports focused on the treatment of proximally located aneurysms. We report our experience with FDs in the treatment of aneurysms at and beyond the circle of Willis.
  15. ncbi The role of circle of Willis anomalies in cerebral aneurysm rupture
    Marc A Lazzaro
    Department of Neurology, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, Wisconsin, USA
    J Neurointerv Surg 4:22-6. 2012
    ..Cerebral aneurysms have been associated with circle of Willis anomalies but whether this association is also related to aneurysm rupture is not known...
  16. pmc A computational model study of the influence of the anatomy of the circle of willis on cerebral hyperperfusion following carotid artery surgery
    Fuyou Liang
    Computational Science Research Program, RIKEN, Wako, Saitama, Japan
    Biomed Eng Online 10:84. 2011
    ..The purpose of this study is to investigate whether and how the anatomy of the Circle of Willis (CoW) of the cerebral circulation influences post-CAS cerebral hyperperfusion.
  17. ncbi Anatomical variants of the circle of willis and brain lesions in migraineurs
    C Cavestro
    Department of Neurology, San Lazzaro Hospital, Alba, Italy
    Can J Neurol Sci 38:494-9. 2011
    ..vascular alterations in brain magnetic resonance imaging (MRI) in migraineurs and a relationship between circle of Willis (Circle) variants and lacunar brain infarcts...
  18. ncbi Characteristics of circle of Willis variations in the mongolian gerbil and a newly established ischemia-prone gerbil group
    Xiao Yan Du
    Department of Laboratory Animal Science, School of Basic Medical Science, Capital Medical University, Beijing, China
    ILAR J 52:E1-7. 2011
    Mongolian gerbils (Meriones unguiculatus) have an incomplete circle of Willis (CoW), as a result of which approximately 30-40% of these animals develop focal cerebral ischemia after unilateral carotid occlusion (UCO)...
  19. ncbi Stent reconstruction of wide-necked aneurysms across the circle of Willis
    Michael E Kelly
    Division of Cerebrovascular and Endovascular Neurosurgery, Department of Neurosurgery, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurosurgery 61:249-54; discussion 254-5. 2007
    To describe a novel technique for single stent reconstruction of wide-necked aneurysms arising from the circle of Willis.
  20. ncbi Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles
    Thomas G Beach
    W H Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 113:13-21. 2007
    ..by three independent groups have found a significant statistical association between postmortem measures of circle of Willis atherosclerosis and AD...
  21. ncbi Arteriogenesis in hypoperfused rat brain
    Hans Jörg Busch
    Max Planck Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany
    J Cereb Blood Flow Metab 23:621-8. 2003
    ..Three-vessel occlusion is a reliable model for the induction of arteriogenesis in the adult brain and is a new approach for exploring the potentials of arteriogenesis for the prevention of progressing brain ischemia...
  22. ncbi Collateral variations in circle of willis in atherosclerotic population assessed by means of transcranial color-coded duplex ultrasonography
    A W Hoksbergen
    Department of Vascular Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Stroke 31:1656-60. 2000
    ..combined with common carotid artery (CCA) compression can be used to assess the collateral function of the circle of Willis. The aim of this study was to assess the unknown fraction of hemodynamic functional anterior and posterior ..
  23. ncbi Modeling blood flow circulation in intracranial arterial networks: a comparative 3D/1D simulation study
    L Grinberg
    Division of Applied Mathematics, Brown University, 182 George St, Providence, RI 02912, USA
    Ann Biomed Eng 39:297-309. 2011
    ..Sensitivity of the flow and pressure with respect to variation in the elasticity parameters is investigated with the 1D model...
  24. ncbi Changes in blood flow of anterior and middle cerebral arteries following carotid endarterectomy: a transcranial Doppler study
    C K Maltezos
    Department of Vascular Surgery, General Hospital Georgios Gennimatas, Athens, Greece
    Vasc Endovascular Surg 41:389-96. 2007
    ..The aim of the present study was to evaluate the changes in blood flow of anterior and middle cerebral arteries following carotid endarterectomy, using transcranial Doppler (TCD) flow studies...
  25. ncbi Collateral circulation via the ophthalmic artery or leptomeningeal vessels is associated with impaired cerebral vasoreactivity in patients with symptomatic carotid artery occlusion
    J Hofmeijer
    University Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 14:22-6. 2002
    ..been considered secondary collaterals, which are recruited only if the primary collateral circulation via the circle of Willis is insufficient...
  26. ncbi Incomplete posterior circle of willis: a risk factor for migraine?
    Jean Marc Bugnicourt
    Department of Neurology, Amiens University Hospital, Amiens, France
    Headache 49:879-86. 2009
    ..hypoperfusion is known to be one mechanism underlying WMA and a few studies have shown that an incomplete circle of Willis (CW) may predispose to cerebral hypoperfusion...
  27. ncbi One-dimensional and three-dimensional models of cerebrovascular flow
    S M Moore
    Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    J Biomech Eng 127:440-9. 2005
    The Circle of Willis is a ring-like structure of blood vessels found beneath the hypothalamus at the base of the brain. Its main function is to distribute oxygen-rich arterial blood to the cerebral mass...
  28. ncbi The anatomic variations of the circle of Willis in preterm-at-term and term-born infants: an MR angiography study at 3T
    C Malamateniou
    Department of Imaging Sciences, Imperial College London, London, UK
    AJNR Am J Neuroradiol 30:1955-62. 2009
    ..Our aims were to establish reference data for the prevalence of the anatomic variations of the neonatal circle of Willis (CoW) and to explore the effect of prematurity, MR imaging abnormality, vascular-related abnormality, ..
  29. ncbi Posterior communicating artery hypoplasia as a risk factor for acute ischemic stroke in the absence of carotid artery occlusion
    Yu Ming Chuang
    Department of Neurology, Tao Yuan General Hospital, Tao Yuan City, Tao Yuan, Taiwan
    J Clin Neurosci 15:1376-81. 2008
    Posterior communicating artery (PCoA) hypoplasia is a fetal variant of the Circle of Willis. According to angiograms and autopsy reports, this congenital variation is found in 6-21% of the general population...
  30. ncbi Incomplete circle of Willis and right axillary artery perfusion
    Päivi Merkkola
    Department of Thoracic and Cardiovascular Surgery, Kuopio University Hospital, Kuopio, Finland
    Ann Thorac Surg 82:74-9. 2006
    ..We considered that critical arteries to examine are anterior and left posterior communicating arteries of the circle of Willis because the absence or insufficiency of either one would drastically endanger perfusion to the left ..
  31. ncbi Some variations of the circle of Willis, important for cerebral protection in aortic surgery--a study in Eastern Europeans
    Vassil Papantchev
    Department of Anatomy and Histology, Medical University, 1 G Sofiiski Street, 1431 Sofia, Bulgaria
    Eur J Cardiothorac Surg 31:982-9. 2007
    ..For perfusion of the contralateral (left) hemisphere it is counted on the competence of the circle of Willis (CoW). It is well known that variations of CoW are present in more than 50% of the people...
  32. ncbi A longitudinal study of collateral flow patterns in the circle of Willis and the ophthalmic artery in patients with a symptomatic internal carotid artery occlusion
    D R Rutgers
    Department of Radiology, University Medical Center Utrecht, The Netherlands
    Stroke 31:1913-20. 2000
    The purpose of the present study was to assess whether the direction of flow via the circle of Willis and the ophthalmic artery (OphA) changed over time in patients with a symptomatic occlusion of the internal carotid artery (ICA) who did ..
  33. ncbi An autopsy study of atherosclerosis in aorta, common carotid arteries and circle of Willis
    Kanchan Kopoor
    Department of Anatomy, Government Medical College, Chandigarh, India
    Nepal Med Coll J 6:69-77. 2004
    ..incidence, extent and degree of atherosclerosis was studied in descending aorta, common carotid arteries and circle of Willis obtained from 50 cadavers above the age of 30 years...
  34. ncbi Presence of anatomical variations of the circle of Willis in patients undergoing surgical treatment for ruptured intracranial aneurysms
    Nebojsa Stojanović
    Clinical Center Nis, Department of Neurosurgery, Nis, Serbia
    Vojnosanit Pregl 66:711-7. 2009
    ..This study investigated the relation between ruptured aneurysms and anatomical configuration of the Circle of Willis, with the purpose to obtain an insight into their mutual connection.
  35. ncbi Collateral ability of the circle of Willis in patients with unilateral internal carotid artery occlusion: border zone infarcts and clinical symptoms
    J Hendrikse
    Departments of Radiology, University Medical Center Utrecht, The Netherlands
    Stroke 32:2768-73. 2001
    The circle of Willis is regarded as the major source of collateral flow in patients with severe carotid artery disease...
  36. ncbi Assessment of the collateral function of the circle of Willis: three-dimensional time-of-flight MR angiography compared with transcranial color-coded duplex sonography
    Arjan W J Hoksbergen
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 24:456-62. 2003
    ..We investigated the usefulness of MR angiography in identifying functional collaterals of the circle of Willis.
  37. ncbi Configuration of the circle of Willis, direction of flow, and shape of the aneurysm as risk factors for rupture of intracranial aneurysms
    Nicolien K de Rooij
    Dept of Neurology, Rudolf Magnus Institute of Neuroscience, Room H02 128, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Neurol 256:45-50. 2009
    ..We studied whether configuration of the circle of Willis, direction of flow towards the aneurysm, and shape of the aneurysm are risk factors for rupture.
  38. ncbi Comparative morphological variations and abnormalities of circles of Willis: a minireview including two personal cases
    Ljiljana Vasovic
    Department of Anatomy, Faculty of Medicine, Bul Braće Tasković 81, 18000 Nis, Yugoslavia
    Neurosurg Rev 25:247-51. 2002
    Two rare cases of the circle of Willis are presented. One of them represents a fetal circle of Willis (crown-rump length, or CRL, 17 cm), the other one is adult circle from a male cadaver 65 years of age...
  39. ncbi The fetal variant of the circle of Willis and its influence on the cerebral collateral circulation
    A Fleur van Raamt
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 22:217-24. 2006
    In a fetal-type posterior circle of Willis (FTP) there is an embryonic derivation of the posterior cerebral artery (PCA) from the internal carotid artery (ICA)...
  40. ncbi A fetal circle of Willis is associated with a decreased deep white matter lesion load
    K Ikeda
    Neurology 64:2163-4; author reply 2163-4. 2005
  41. ncbi Expression of alpha2-macroglobulin, neutrophil elastase, and interleukin-1alpha differs in early-stage and late-stage atherosclerotic lesions in the arteries of the circle of Willis
    Sergey Larionov
    Department of Neuropathology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Acta Neuropathol 113:33-43. 2007
    ..the proinflammatory protein interleukin-1alpha (IL-1alpha) in all types of AS plaques in the arteries of the circle of Willis from 78 human autopsy cases of both genders (61-91 years of age)...
  42. ncbi Relationship between variations in the circle of Willis and flow rates in internal carotid and basilar arteries determined by means of magnetic resonance imaging with semiautomated lumen segmentation: reference data from 125 healthy volunteers
    H Tanaka
    Department of Radiology, Osaka University Medical School, Osaka, Japan
    AJNR Am J Neuroradiol 27:1770-5. 2006
    ..Although these flow values are thought to be effected by anatomic variations in the circle of Willis, few reports have described the effect...
  43. ncbi Assessment of flow changes in the circle of Willis after stenting for severe internal carotid artery stenosis
    Anna Kablak-Ziembicka
    Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    J Endovasc Ther 13:205-13. 2006
    ..To assess flow velocities in the cerebral arteries after carotid artery stenting (CAS) in patients with unilateral versus bilateral lesions and analyze velocities in patients with neurological complications after CAS...
  44. pmc Are the distributions of variations of circle of Willis different in different populations? - Results of an anatomical study and review of literature
    Behzad Eftekhar
    Sina Trauma and Surgery Research Center and Department of Neurosurgery, Sina Hospital, Tehran University, Tehran, Iran
    BMC Neurol 6:22. 2006
    Previous studies have proposed correlation between variants of the cerebral arterial circle (also known as circle of Willis) and some cerebrovascular diseases...
  45. ncbi The intronic deletion polymorphism of the Alpha2- macroglobulin gene modulates the severity and extent of atherosclerosis in the circle of Willis
    S Larionov
    Neuropathol Appl Neurobiol 32:451-4. 2006
  46. ncbi Localization of the m5 muscarinic cholinergic receptor in rat circle of Willis and pial arteries
    S K Tayebati
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Neuroscience 122:205-11. 2003
    ..and microanatomical localization of the muscarinic cholinergic m5 receptor subtype was investigated in rat circle of Willis and pial arteries by in situ hybridization, immunoblotting and immunohistochemistry...
  47. ncbi Multiple intracranial arterial stenoses around the circle of Willis in association with Graves' disease: report of two cases
    Kazuhiro Nakamura
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurosurgery 53:1210-4; discussion 1214-5. 2003
    ..The association of Graves' disease with multiple intracranial arterial stenoses is rare...
  48. ncbi Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Arterioscler Thromb Vasc Biol 23:2055-62. 2003
    ..We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer's disease (AD)...
  49. ncbi Direction of flow in posterior communicating artery on magnetic resonance angiography in patients with occipital lobe infarcts
    Jacqueline C F Jongen
    Department of Neurology, Hospital Zevenaar, PO Box 9000, 6900 GA Zevenaar, Netherlands
    Stroke 35:104-8. 2004
    ..We studied the presence and direction of flow in the posterior communicating artery (PCoA) in patients with an occipital lobe infarct and in healthy controls...
  50. ncbi A fetal circle of Willis is associated with a decreased deep white matter lesion load
    J van der Grond
    Department of Radiology, E01 132, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Neurology 63:1452-6. 2004
    To investigate the relationship between morphologic differences in the circle of Willis and the presence and location of white matter lesions (WMLs).
  51. ncbi Incompetent circle of Willis and vertebrobasilar insufficiency
    Louis W Welsh
    Ann Otol Rhinol Laryngol 112:657-64. 2003
    ..or more of the source vessels, the internal carotid and vertebral arteries, in conjunction with an incomplete circle of Willis increased the potential for hindbrain perfusion deficits...
  52. ncbi Double-balloon remodeling of wide-necked aneurysms distal to the circle of Willis
    Anil Arat
    Department of Radiology, Hacettepe University Hospitals, Ankara, Turkey
    AJNR Am J Neuroradiol 26:1768-71. 2005
    ..two compliant balloon catheters were used to treat large, wide-necked bifurcation aneurysms distal to the circle of Willis in two patients with subarachnoid hemorrhage...
  53. ncbi Variations in the configuration of the circle of Willis
    Kanchan Kapoor
    Department of Anatomy, Government Medical College, 1404 Sector 42B, Chandigarh, India
    Anat Sci Int 83:96-106. 2008
    ..These variations are discussed with regard to development and other hemodynamic factors...
  54. ncbi Morphology and comparative anatomy of circulus arteriosus cerebri in mammals
    K Kapoor
    Department of Anatomy, Government Medical College, Chandigarh Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Anat Histol Embryol 32:347-55. 2003
    ..In rhesus monkeys, dogs and rabbits, the circle of Willis is almost similar to that in human beings except that in these animals, (i) the anterior cerebral arteries ..
  55. ncbi Intracranial aneurysms: evaluation in 200 patients with spiral CT angiography
    N Young
    Department of Radiology, Westmead Hospital, Wentworthville NSW, Australia
    Eur Radiol 11:123-30. 2001
    ..CTA) with three- dimensional reconstructions in defining intracranial aneurysms, particularly around the Circle of Willis. Two hundred consecutive patients with angiographic and/or surgical correlation were studied between 1993 and ..
  56. ncbi Incomplete oculomotor nerve palsy caused by an unruptured internal carotid-anterior choroidal artery aneurysm--case report--
    Yasutaka Kurokawa
    Division of Neurosurgery, Asahikawa Neurosurgical Hospital, Hokkaido
    Neurol Med Chir (Tokyo) 45:143-7. 2005
    ....
  57. ncbi Complex intracranial arterial anatomy in swine is unsuitable for cerebral infarction projects
    Brent Burbridge
    Department of Medical Imaging, Royal University Hospital, Saskatoon, Sask
    Can Assoc Radiol J 55:326-9. 2004
    ..To see whether swine provide a suitable animal model for cerebral ischemia research projects related to apoptosis. Swine angiograms had not been obtained previously in our institution...
  58. ncbi Rupture of a cerebral aneurysm during MR Imaging: leakage of gadolinium into the subarachnoid space
    Rodney S Allan
    AJNR Am J Neuroradiol 26:200-1. 2005
  59. ncbi Unilateral pterional approach to bilateral aneurysms of the middle cerebral artery
    Atos Alves de Sousa
    Faculdade de Ciencias Medicas de Minas Gerais, Santa Casa de Belo Horizonte, Belo Horizonte, MG 30150 310, Brazil
    Surg Neurol 63:S1-7. 2005
    ....
  60. ncbi [Anatomical study and three dimensional image characteristic analysis of basicranial artery and its clinical significance]
    Hua Yang
    Department of Neurosurgery, Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China
    Zhonghua Yi Xue Za Zhi 83:13-7. 2003
    ..To observe and measure the inside diameter of basicranial arteries, the angulation of main arteries, the three dimensional image characteristic of internal carotid arteries and the anatomical variation of Willis circle...
  61. ncbi Spect measurements of regional cerebral perfusion and carbondioxide reactivity: correlation with cerebral collaterals in internal carotid artery occlusive disease
    Michiel J de Boorder
    Department of Radiology, University Medical Center, Utrecht, The Netherlands
    J Neurol 253:1285-91. 2006
    ..The aim of the present study was to assess the regional variation in cerebral perfusion, vasomotor reactivity (VMR) and the role of cerebral collaterals in patients with symptomatic internal carotid artery (ICA)...
  62. ncbi Pituitary apoplexy associated with anterior communicating artery aneurysm and aberrant blood supply
    Kiarash Shahlaie
    Department of Neurological Surgery, University of California at Davis Medical Center, Sacramento, California, USA
    J Clin Neurosci 13:1057-62. 2006
    ..This recurrent hypophyseal artery established a direct vascular relationship between an intracerebral aneurysm and the pituitary gland...
  63. ncbi Anatomic variations in the circle of Willis in patients with symptomatic carotid artery stenosis assessed with multidetector row CT angiography
    A Waaijer
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 23:267-74. 2007
    To assess the presence of anterior and posterior collateral pathways in the circle of Willis in patients with symptomatic carotid artery stenosis (SCAS) and to compare this to patients without carotid artery stenosis.
  64. ncbi Carotid-anterior cerebral artery anastomosis: MR angiographic features and literature review
    Akiro Uchino
    Department of Radiology, Saga Medical School, 5 1 1, Nabeshima, Saga 849 8501, Japan
    Clin Imaging 28:377-80. 2004
    Carotid-anterior cerebral artery anastomosis is a rare anomaly of the anterior part of the circle of Willis. We report here magnetic resonance (MR) angiographic findings in 2 patients with this anomaly...
  65. ncbi The value of phase-contrast magnetic resonance angiography of the circle of Willis in predicting cerebral ischemia-hypoxia (shunt need) during carotid endarterectomy
    P Bagan
    Department of Thoracic and Vascular Surgery, Avicenne Hospital, AP HP, University Paris XIII, Bobigny, France
    Surg Radiol Anat 27:544-7. 2005
    Cerebral perfusion during carotid cross-clamping depends on collateral function of the circle of Willis. The aim of this study was to determine the value of 3D Phase-Contrast (3D PC) MR angiography in predicting pre-operatively the need ..
  66. ncbi Flow redistribution in the major cerebral arteries after carotid endarterectomy: a study with transcranial Doppler scan
    E M Vriens
    Department of Clinical Neurophysiology, University Medical Centre Utrecht, The Netherlands
    J Vasc Surg 33:139-47. 2001
    ..This open single-center prospective study aimed to determine the redistribution of blood flow within the circle of Willis and through collateral pathways after carotid endarterectomy...
  67. ncbi A case of Horner syndrome with intermittent mydriasis in a patient with hypoplasia of the internal carotid artery
    M Ibrahim
    Department of Radiology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 27:1318-20. 2006
    ....
  68. ncbi Magnetic resonance angiography of cerebral arteries after neonatal venoarterial and venovenous extracorporeal membrane oxygenation
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, The Netherlands
    Stroke 37:e15-7. 2006
    ..The authors present the magnetic resonance angiography (MRA) evaluation of cerebral hemodynamics in a case of venoarterial and a case of venovenous ECMO...
  69. ncbi Spurious absence of signal on 3D time-of-flight MR angiograms on 1 and 3 tesla magnets in cerebral arteries associated with a giant ophthalmic segment aneurysm: the need for alternative techniques
    B Thomas
    Department of Radiology, University Hospitals, KULeuven, Leuven, Belgium
    JBR-BTR 88:241-4. 2005
    There are many high-resolution MR angiographic techniques available today for the evaluation of circle of Willis. We report a case of bilateral aneurysms of the carotico-ophthalmic segment, the left one being a giant aneurysm, in a 41-..
  70. ncbi Evaluation of cerebral circulation in patients with significant carotid artery stenosis
    Anna Kabłak-Ziembicka
    Institute of Cardiology, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Kardiol Pol 63:381-9; discussion 390. 2005
    ..Assessment of haemodynamical profile of cerebral arteries in both symptomatic and asymptomatic patients with carotid artery stenosis is of clinical importance...
  71. ncbi Hyperplastic anterior choroidal artery identified using magnetic resonance angiography: a report of two cases
    Letizia C L Antonietti
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, CA 94143 0628, USA
    Cerebrovasc Dis 22:450-2. 2006
  72. ncbi [Cerebral aneurysms diagnosis by three-dimensional CT angiography]
    Guilherme Cabral de Andrade
    Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Arq Neuropsiquiatr 61:74-8. 2003
    ..method presents a 100% specificity and can reach 95% of sensibility in the evaluation of the aneurysms in the circle of Willis, substituting the digital angiography but not in all of the cases...
  73. ncbi Successful treatment of a blood blister-like aneurysm of the internal carotid artery by trapping with a high-flow bypass
    Akitsugu Kawashima
    Department of Neurosurgery, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Clin Neurosci 15:797-800. 2008
    ..Trapping of the ICA with a bypass, if necessary a high-flow bypass, is recommended...
  74. ncbi Giant and large peripheral cerebral aneurysms: etiopathologic considerations, endovascular treatment, and long-term follow-up
    A Biondi
    Department of Neuroradiology, Pitie Salpetriere Hospital, Paris VI University School of Medicine, Paris, France
    AJNR Am J Neuroradiol 27:1685-92. 2006
    Giant/large peripheral cerebral aneurysms beyond the circle of Willis and middle cerebral artery (MCA) bifurcation are rare lesions, their etiopathogenesis is not completely elucidated, and their treatment is often difficult...
  75. ncbi In vivo flow territory mapping of major brain feeding arteries
    Peter Jan van Laar
    Department of Radiology Hp E01 332, University Medical Center, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Neuroimage 29:136-44. 2006
    ..However, when the subjects are further categorized into groups with a complete circle of Willis, with a missing A1 segment and with a unilateral or bilateral fetal-type posterior cerebral artery, the ..
  76. ncbi Diagnosing cerebral collateral flow patterns: accuracy of non-invasive testing
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 25:430-7. 2008
    ....
  77. ncbi Configuration of intracranial arteries and development of aneurysms: a follow-up study
    A Stijntje E Bor
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Neurology 70:700-5. 2008
    ..The reasons for development of intracranial aneurysms are unknown; hemodynamic factors may play an important role in this process. We performed a cohort study to further elicit the role of intracranial arterial geometry...
  78. ncbi Patient-specific computational modeling of cerebral aneurysms with multiple avenues of flow from 3D rotational angiography images
    Marcelo A Castro
    School of Computational Sciences, George Mason University, 4400 University Drive, MSN 4C7, Fairfax, VA 22030, USA
    Acad Radiol 13:811-21. 2006
    ..However, aneurysms of the circle of Willis frequently involve locations with more than one source of inflow, such as aneurysms of the anterior ..
  79. ncbi Loss of visual evoked potential following temporary occlusion of the superior hypophyseal artery during aneurysm clip placement surgery. Case report
    Tetsuya Goto
    Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan
    J Neurosurg 107:865-7. 2007
    ..The patient did not have any deterioration of vision after surgery. Intraoperative VEP monitoring can be used to help determine whether the SHA can be sacrificed safely...
  80. ncbi Endangered cerebral blood supply after closure of left subclavian artery: postmortem and clinical imaging studies
    Hannu Manninen
    Department of Radiology, Diagnostic Medical Imaging Centre, Kuopio University Hospital and Kuopio University, Kuopio, Finland
    Ann Thorac Surg 85:120-5. 2008
    ..The existence and the diameters of these arteries were studied in a postmortem anatomic study with review of clinical craniocervical computed tomographic (CT) and magnetic resonance (MR) angiographies...
  81. ncbi Effect of carotid endarterectomy on primary collateral blood flow in patients with severe carotid artery lesions
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 34:1650-4. 2003
    ..internal carotid artery (ICA), it is recognized that the preoperative failure to visualize collaterals of the circle of Willis increases the risk of hemispheric ischemia before, during, and after carotid endarterectomy (CEA)...
  82. ncbi Ruptured aneurysm associated with partially duplicated posterior communicating artery--case report
    Masanori Hashimoto
    Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
    Neurol Med Chir (Tokyo) 42:23-6. 2002
    ..A curved Yasargil clip was used to clip the aneurysm and preserve the PcoA and branches. Careful observation of this PcoA variation is needed because the arterial structures may be hidden by the thickened arachnoid membrane...
  83. ncbi Blood flow dynamics in patient-specific cerebral aneurysm models: the relationship between wall shear stress and aneurysm area index
    Alvaro Valencia
    Department of Mechanical Engineering, Universidad de Chile, Casilla 2777, Santiago, Chile
    Med Eng Phys 30:329-40. 2008
    ..models of saccular aneurysms located in the region of the anterior and posterior circulation of the circle of Willis. The models were obtained from three-dimensional rotational angiography image data and blood flow dynamics ..
  84. ncbi Agenesis of the left internal carotid artery associated with right anterior cerebral artery A1 segment bifurcation aneurysm: a case report
    B Demirgil
    Bakirkö Psychiatric and Neurological Diseases Hospital, 2nd Neurosurgery Clinic, Istanbul, Turkey
    Minim Invasive Neurosurg 50:300-3. 2007
    ..Intracranial aneurysms accompany agenesis in 25-43% of the patients. We present a unique patient with a saccular aneurysm of the anterior communicating artery associated with agenesis of contralateral internal carotid artery...
  85. ncbi [Results of 25-years study of bifurcational aneurysms of the cerebral arteries in the cranial base]
    Iu A Medvedev
    A L Polenov Russian Neurosurgical Institute, 191104, Saint Petersburg
    Arkh Patol 65:31-6. 2003
    ..The authors are in favor of the hypothesis on the acquired (rather than congenital) origin of aneurysms (diverticula) that are an optional manifestation of DJCAC...
  86. ncbi Complete neck clipping of internal carotid-posterior communicating artery aneurysms using bayonet-shaped aneurysm clips: technical note
    Hiroshi Kashimura
    Department of Neurosurgery, Iwate Medical University School of Medicine, Morioka, Iwate, Japan
    Neurol Med Chir (Tokyo) 47:282-4; discussion 284. 2007
    ..Postoperative cerebral angiography demonstrated no residual aneurysm neck and preservation of the Pcom in all patients. This technique is useful for cases of IC-PC aneurysm involving the origin of the Pcom...
  87. ncbi Magnetic resonance angiography in childhood arterial brain infarcts: a comparative study with contrast angiography
    Beatrice Husson
    Service de Radiologie, Hopital Bicetre, Universite Paris XI, Le Kremlin Bicetre, France
    Stroke 33:1280-5. 2002
    ..We sought to compare the results of MRA with those of CA for the study of cerebral arteries in children with arterial infarction in an arterial distribution...
  88. ncbi Treatment of an anterior communicating artery aneurysm through an anomalous anastomosis from the cavernous internal carotid artery
    Virany Huynh Hillard
    Department of Neurosurgery, New York Medical College, Valhalla, New York, USA
    J Neurosurg 97:1432-5. 2002
    ..The presence of the anomalous vessel provided a straightforward endovascular approach to the ACoA and allowed the use of coil placement rather than surgical clipping to treat the aneurysm successfully...
  89. ncbi The circle of Willis in healthy older persons
    C Macchi
    Department of Cardiovascular Medicine, Don Gnocchi Foundation, Florence, Italy
    J Cardiovasc Surg (Torino) 43:887-90. 2002
    ..This approach shows many limitations, one of which is to presume the anatomical completeness of the circle of Willis in all patients who are evaluated...
  90. ncbi Randomly segmented central k-space ordering in high-spatial-resolution contrast-enhanced MR angiography of the supraaortic arteries: initial experience
    Winfried A Willinek
    Department of Radiology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Radiology 225:583-8. 2002
    ..CENTRA enabled reliable depiction of the aortic arch up to the circle of Willis at high spatial resolution (true voxel size, 0.81 x 0.81 x 1.0 mm(3))...
  91. ncbi Magnetic resonance angiography of collateral compensation in asymptomatic and symptomatic internal carotid artery stenosis
    Jeroen Hendrikse
    Department of Radiology, University Medical Center, Utrecht, The Netherlands
    J Vasc Surg 36:799-805. 2002
    ..The purpose of the present study was to determine whether patients with asymptomatic stenosis of the ICA have a better collateral ability of the circle of Willis when compared with patients with symptomatic ICA stenosis.
  92. ncbi Hemodynamic and metabolic changes in transient ischemic attack patients: a magnetic resonance angiography and (1)H-magnetic resonance spectroscopy study performed within 3 days of onset of a transient ischemic attack
    Robertus H C Bisschops
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 33:110-5. 2002
    ..attack (TIA) have systemic low flow to the brain or an abnormal intracranial flow distribution caused by an abnormal anatomy of the circle of Willis. Furthermore, we investigated whether metabolic changes were present in the brain.
  93. ncbi Carotid endarterectomy in a patient with persistent proatlantal artery
    Julia Schoof
    Department of Neurology, University Hospital of Magdeburg, Magdeburg, Germany
    Cerebrovasc Dis 23:458-9. 2007
  94. ncbi [Increased cerebrovascular reactivity and risk factors for ischaemic stroke in patients with inadequate circulation in the posterior circle of Willis]
    Janusz Kwieciński
    Katedry i Kliniki Neurologii w Zabrzu Slaskiej Akademii Medycznej w Katowicach
    Wiad Lek 56:319-23. 2003
    ....
  95. ncbi Sensitivity encoding (SENSE) for high spatial resolution time-of-flight MR angiography of the intracranial arteries at 3.0 T
    W A Willinek
    Department of Radiology, University of Bonn, Germany
    Rofo 176:21-6. 2004
    ..0 T using a 1024 imaging matrix and 2) to compare image quality and diagnostic yield with 3.0 T TOF MRA without SENSE...
  96. ncbi Bilateral severe carotid artery stenosis or occlusion - cerebral autoregulation dynamics and collateral flow patterns
    M Reinhard
    Department of Neurology and Clinical Neurophysiology, University of Freiburg, Freiburg, Germany
    Acta Neurochir (Wien) 145:1053-9; discussion 1059-60. 2003
    ..We aimed to (1) analyze dynamic cerebral autoregulation (DCA) in affected patients, and (2) to correlate DCA data with different collateral flow patterns...
  97. ncbi Three-dimensional cerebral vasculature of the CBA mouse brain: a magnetic resonance imaging and micro computed tomography study
    A Dorr
    Sunnybrook Health Sciences Centre, 3080 Yonge Street, Suite 6020, P O Box 89, Toronto, ON, Canada M4N 3N1
    Neuroimage 35:1409-23. 2007
    Studies of mouse cerebral vasculature to date have focused on the circle of Willis without examining the morphological distribution of blood vessels through the rest of the brain...
  98. ncbi Effects of RF inhomogeneity at 3.0T on ramped RF excitation: application to 3D time-of-flight MR angiography of the intracranial arteries
    Amir M Eissa
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    J Magn Reson Imaging 25:466-72. 2007
    ..0T, and to introduce a simple correction for improving visualization of distal intracranial arteries in three-dimensional time-of-flight MR angiography (3D-TOF-MRA)...
  99. ncbi Symptomatic carotid artery occlusion: flow territories of major brain-feeding arteries
    Peter Jan van Laar
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Radiology 242:526-34. 2007
    ..To prospectively investigate the extent of flow territories of the contralateral internal carotid artery (ICA) and vertebrobasilar arteries in patients with symptomatic ICA occlusion...
  100. ncbi A rare anomaly of the anterior communicating artery complex hidden by a large broad-neck aneurysm and disclosed by three-dimensional rotational angiography
    Jean G de Oliveira
    Neurocenter, Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Acta Neurochir (Wien) 150:279-84; discussion 284. 2008
    ..The DSA images missed the double fenestration which was disclosed by 3D-RA, indicating the importance of 3D-RA in the diagnosis and surgical planning of intracranial aneurysms...
  101. ncbi [The importance of Willis ring as valvular mechanism in cerebral circulation in patients with different degree of internal carotid artery occlusion]
    Alma Volievica
    Institut za anatomiju Prof dr Hajrudin Hadziselimovic, Medicinski fakultet Univerziteta u Sarajevu
    Med Arh 60:339-42. 2006
    ..Studies till now have shown that all components of Willis ring do not contribute equally in colateral function among obstructive diseases...

Research Grants32

  1. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    An emerging literature and preliminary data suggest that circle of Willis anomalies are more prevalent in migraine patients than in the general population...
  2. Epidemiology of Aging and Dementia-Autopsy Research
    LON RAY WHITE; Fiscal Year: 2010
    ..of microinfarcts and Alzheimer's lesions, (3) relationships between structural characteristics of Circle of Willis arteries and lesions in the brain parenchyma, and (4) identification of the major underlying pathogenic ..
  3. ANGIOPLASTY IN ANEURYSMAL SUBARACHNOID HEMORRHAGE
    J Muizelaar; Fiscal Year: 2005
    ..In the severe group, TBA will be performed on all vessels forming the Circle of Willis, in the less severe group, only the aneurysm-bearing part of the circulation...
  4. HUMAN BRAIN FUNCTION IN INDUCED CEREBRAL HYPOPERFUSION
    RANDOLPH MARSHALL; Fiscal Year: 2001
    ..cerebral hypoperfusion and simultaneously measuring quantitative cerebral blood flow, alterations in circle of Willis collaterals, and brain tissue oxygenation, we have an opportunity to develop a human model of ischemia that ..
  5. Image-guided treatment planning for neuro-interventions
    Kenneth Hoffmann; Fiscal Year: 2006
    ..Devices are being placed above the Circle of Willis. Currently, interventionalists are judging accessibility via the proximal vessels using only subjective ..
  6. Epidemiology of Aging and Dementia-Autopsy Research
    Lon White; Fiscal Year: 2007
    ..of microinfarcts and Alzheimer's lesions, (3) relationships between structural characteristics of Circle of Willis arteries and lesions in the brain parenchyma, and (4) identification of the major underlying pathogenic ..
  7. PEROXYNITRITE MEDIATED MECHANISMS IN CEREBRAL ISCHEMIA
    WILLIAM CHILIAN; Fiscal Year: 2001
    ..In the proposed experiments, we will use freshly isolated cells and vessels from the rat brain Circle of Willis arteries...
  8. FLUID DYNAMICS IN TRANSPARENT NATURAL BLOOD VESSELS
    Takeshi Karino; Fiscal Year: 1990
    ..focus our study on the pathogenesis of saccular aneurysms at the major bifurcations and T-junctions of the circle of Willis. We will also improve our electric circuit model of the human circle of Willis and study the effects of multi ..
  9. Trigeminal Neuralgia Association 5th National Conference
    Albert Rhoton; Fiscal Year: 2005
    ..abstract_text> ..
  10. BOEC in Biology
    Robert Hebbel; Fiscal Year: 2005
    ..Aside from eventual therapeutics, these studies will define aspects of this unique cell type. ..
  11. THE VALIDITY OF CE-MRA: A NUMERICAL AND PHANTOM STUDY
    Liang Der Jou; Fiscal Year: 2002
    ..It is anticipated that this project will provide improved tools for the understanding of Contrast-Enhanced MRA and will lead to more accurate and reliable methods for assessing vascular disease in vivo. ..
  12. 2008 Summer Bioengineering Conference
    Baruch Lieber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. DEVELOPMENTAL HEMATO-ENDOTHELIAL BIOLOGY OF P1H12
    Robert Hebbel; Fiscal Year: 2002
    ..These studies represent a first step towards defining the role of P1H12 in embryology, with an emphasis on hematopoiesis and vasculogenesis (as rationalized by exciting preliminary data). ..
  14. ERYTHROCYTE MEMBRANE ABNORMALITIES IN SICKLE DISEASE
    Robert Hebbel; Fiscal Year: 2002
    ..These studies will rigorously test our hypotheses regarding the participation of TSP and CD36 in mediating sickle RBC adhesion to endothelium. ..
  15. GENETICALLY ENGINEERED ANTI ANGIOGENIC ANTI GLIOMA CTL'S
    Bob Carter; Fiscal Year: 2005
    ..abstract_text> ..
  16. Application of ALGEL for embolization of aneurysms
    Timothy Becker; Fiscal Year: 2004
    ..We feel that it is highly likely that ALGEL will turn out to be a clinically useful material. ..
  17. ENDOTHELIAL CELL OUTGROWTH FROM BLOOD
    Robert Hebbel; Fiscal Year: 2001
    ..abstract_text> ..
  18. Substance Abuse and HIV: Genetics and Disease Progression
    Howard Crystal; Fiscal Year: 2009
    ..Using all relevant longitudinal data, we will evaluate the effects of gene polymorphisms on the risk of persistent substance abuse, on progression to AIDS and to death, and on the risk of depression. ..
  19. Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    William C Culp; Fiscal Year: 2010
    ..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..
  20. THE VALIDITY OF CE-MRA: A NUMERICAL AND PHANTOM STUDY
    Liang Der Jou; Fiscal Year: 2003
    ..It is anticipated that this project will provide improved tools for the understanding of Contrast-Enhanced MRA and will lead to more accurate and reliable methods for assessing vascular disease in vivo. ..
  21. Cortical Spreading Depression, Proteases and Ischemia
    Michael Moskowitz; Fiscal Year: 2008
    ..By doing so, we intend to explore ways in which neuronal activity during cerebral ischemia modulates the extracellular matrix and neurovascular unit and contribute to tissue injury. ..
  22. INTERDEPARTMENTAL STROKE PROGRAM
    Michael Moskowitz; Fiscal Year: 2008
    ..abstract_text> ..
  23. HMG1 SIGNALING IN INFLAMMATION FOLLOWING BRAIN ISCHEMIA
    Michael Moskowitz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. AMYLOIDOGENIC EFFECTS OF CHOLINERGIC DENERVATION
    Thomas Beach; Fiscal Year: 2002
    ..This could lead to impaired cerebral vasoregulation and increased susceptibility to ischemia, further compromising cortical function in AD. ..
  25. Application of alginate for endovascular embolization
    Timothy Becker; Fiscal Year: 2005
    ..The project team includes a core group of physicians, consultants, suppliers, and business alliances that has the technical, medical, and business expertise to make this project successful. ..
  26. TCD Ultrasound of Subjects Enrolled in Baby HUG
    Robert Adams; Fiscal Year: 2004
    ..Although the sample size is purposely small as designed by the parent study, large differences in the prevalence of high-risk patients at the end of treatment could be detected by Baby TCD. ..
  27. REDUCING SPINAL CORD INJURY WITH RETROGRADE PERFUSION
    John Kern; Fiscal Year: 2004
    ..Basic research is needed, however, before applying this technique clinically. ..
  28. MIGRAINE DRUG PROPHYLAXIS
    Michael Moskowitz; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. Caspase Mechanisms after Brain Injury
    Michael Moskowitz; Fiscal Year: 2006
    ..Together these experiments will explore death receptor-mediated acute cell killing within brain in order to identify mechanisms and potential targets of ischemic and traumatic brain injury. ..
  30. Cerebrovascular mechanisms of ischemic injury in diabetes
    Adviye Ergul; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. Mechanism of Endothelial Dysfunction in Diabetes
    Adviye Ergul; Fiscal Year: 2004
    ..The results will lead to the development of novel therapeutic targets for the high-risk diabetic patients and may identify subgroups of patients that would be more suitable for these new treatment strategies. ..