cerebral arteries

Summary

Summary: The arteries supplying the cerebral cortex.

Top Publications

  1. pmc Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools
    S Salomone
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Br J Pharmacol 153:140-7. 2008
  2. ncbi Delayed cell death related to acute cerebral blood flow changes following subarachnoid hemorrhage in the rat brain
    Giselle F Prunell
    Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, Stockholm, Sweden
    J Neurosurg 102:1046-54. 2005
  3. ncbi Arterial spin-labeled perfusion MRI in basic and clinical neuroscience
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Opin Neurol 22:348-55. 2009
  4. ncbi Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
    Am J Physiol Heart Circ Physiol 293:H3750-8. 2007
  5. ncbi Velocity-selective arterial spin labeling
    Eric C Wong
    Department of Radiology, University of California San Diego, La Jolla, 92093, USA
    Magn Reson Med 55:1334-41. 2006
  6. ncbi Comparative velocity investigations in cerebral arteries and aneurysms: 3D phase-contrast MR angiography, laser Doppler velocimetry and computational fluid dynamics
    Dorothea I Hollnagel
    Institute of Neuroradiology, University Hospital Zurich, Zurich, Switzerland
    NMR Biomed 22:795-808. 2009
  7. ncbi Ion channels and calcium signaling in cerebral arteries following subarachnoid hemorrhage
    George C Wellman
    Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Neurol Res 28:690-702. 2006
  8. ncbi ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat
    Saema A S Beg
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 26:846-56. 2006
  9. pmc Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model
    Aida Maddahi
    Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Cereb Blood Flow Metab 31:144-54. 2011
  10. ncbi Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen
    Alyson A Miller
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Stroke 38:2142-9. 2007

Detail Information

Publications287 found, 100 shown here

  1. pmc Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools
    S Salomone
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Br J Pharmacol 153:140-7. 2008
    Sphingosine 1-phosphate (S1P) selectively and potently constricts isolated cerebral arteries, but this response has not been pharmacologically characterized.
  2. ncbi Delayed cell death related to acute cerebral blood flow changes following subarachnoid hemorrhage in the rat brain
    Giselle F Prunell
    Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, Stockholm, Sweden
    J Neurosurg 102:1046-54. 2005
    ....
  3. ncbi Arterial spin-labeled perfusion MRI in basic and clinical neuroscience
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Opin Neurol 22:348-55. 2009
    ....
  4. ncbi Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
    Am J Physiol Heart Circ Physiol 293:H3750-8. 2007
    ..SAH was induced by injecting 250 microl blood into the prechiasmatic cistern in rats. The cerebral arteries were removed 0, 1, 3, 6, 12, 24, and 48 h after the SAH for functional and molecular studies...
  5. ncbi Velocity-selective arterial spin labeling
    Eric C Wong
    Department of Radiology, University of California San Diego, La Jolla, 92093, USA
    Magn Reson Med 55:1334-41. 2006
    ..The technical considerations described here include the design of VS pulses, background suppression, anisotropy with respect to velocity-encoding directions, and CBF quantitation issues...
  6. ncbi Comparative velocity investigations in cerebral arteries and aneurysms: 3D phase-contrast MR angiography, laser Doppler velocimetry and computational fluid dynamics
    Dorothea I Hollnagel
    Institute of Neuroradiology, University Hospital Zurich, Zurich, Switzerland
    NMR Biomed 22:795-808. 2009
    ....
  7. ncbi Ion channels and calcium signaling in cerebral arteries following subarachnoid hemorrhage
    George C Wellman
    Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Neurol Res 28:690-702. 2006
    ..The ability of VDCC blockers or K(+) channel activators to alleviate SAH-induced vasospasm will also be examined...
  8. ncbi ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat
    Saema A S Beg
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 26:846-56. 2006
    ..At 2 days after the SAH, cerebral arteries were harvested for quantitative real-time polymerase chain reaction, immunohistochemistry and analysis of ..
  9. pmc Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model
    Aida Maddahi
    Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Cereb Blood Flow Metab 31:144-54. 2011
    ..After 48 hours, cerebral arteries were harvested, and iNOS, interleukin (IL)-6, IL-1β, matrix metalloproteinase (MMP)-9, tissue inhibitors of ..
  10. ncbi Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen
    Alyson A Miller
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Stroke 38:2142-9. 2007
    ..This study tested whether NADPH-oxidase activity, expression, and functional effects on vascular tone are influenced by gender in the rat cerebral circulation and whether such differences are estrogen-dependent...
  11. pmc Vascular plasticity in cerebrovascular disorders
    Lars I H Edvinsson
    Department of Clinical Experimental Research, Copenhagen University, Glostrup Hospital Research Park, Copenhagen, Denmark
    J Cereb Blood Flow Metab 31:1554-71. 2011
    ..insight obtained during the last decade into plastic changes in the vasoconstrictor receptor profiles of cerebral arteries and microvessels that takes place after different types of stroke...
  12. ncbi Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12
    E Tournier-Lasserve
    Laboratoire de Pathologie de l Immunité INSERM CJF 90 01, Faculte de Medecine Necker Enfants Malades, Paris, France
    Nat Genet 3:256-9. 1993
    ..Multilocus analysis with the location scores method established the best estimate for the location of the affected gene within a 14 centimorgan interval bracketed by D19S221 and D19S222 loci...
  13. pmc Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries
    K Fassbender
    Department of Neurology, University Clinic Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer, 68135 Mannheim, Germany
    J Neurol Neurosurg Psychiatry 70:534-7. 2001
    ..SAH) and control subjects and compared with development of complicating haemodynamic abnormalities in basal cerebral arteries and clinical outcome...
  14. ncbi Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function
    C K Willie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, 3333 University Way, Kelowna, BC, Canada V1V 1V7
    J Neurosci Methods 196:221-37. 2011
    ..The integration of these regulatory mechanisms from an integrated systems perspective is discussed, and future research directions are explored...
  15. pmc A two-stage approach for measuring vascular water exchange and arterial transit time by diffusion-weighted perfusion MRI
    Keith S St Lawrence
    Lawson Health Research Institute, London, Ontario, Canada
    Magn Reson Med 67:1275-84. 2012
    ..The intrasubject coefficient of variation was 26% ± 23% in grey matter and 21% ± 17% in white matter, indicating that reproducible k(w) measurements can be obtained...
  16. pmc Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries
    Ivana Y Kuo
    John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, Australian Capital Territory, Australia
    J Cereb Blood Flow Metab 30:1226-39. 2010
    ..2) and T-type (Ca(V)3.1 and Ca(V)3.2) channels in adult rat basilar and middle cerebral arteries and their branches...
  17. pmc Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells
    Manuel F Navedo
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Am J Physiol Cell Physiol 298:C211-20. 2010
    ..These findings suggest that hyperglycemia increases Ca(2+) influx by increasing Ca(2+) sparklet activity via a PKA-dependent pathway in cerebral arterial myocytes and contributes to vascular dysfunction during diabetes...
  18. ncbi Acute and chronic effects of oxyhemoglobin on voltage-dependent ion channels in cerebral arteries
    M Ishiguro
    Department of Pharmacology, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    Acta Neurochir Suppl 104:99-102. 2008
    ..Recent evidence suggests VDCC activity is increased and Kv channel activity is decreased in cerebral arteries following subarachnoid hemorrhage (SAH), promoting enhanced constriction...
  19. pmc Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation
    Jennifer L Kielczewski
    Program in Stem Cell Biology and Regenerative Medicine, University of Florida, Gainesville, FL 32610, USA
    Circ Res 105:897-905. 2009
    ..This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury...
  20. ncbi Can arterial spin labeling detect white matter perfusion signal?
    Matthias J P van Osch
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Magn Reson Med 62:165-73. 2009
    ..It can be concluded that, except within the deep WM, ASL is sensitive enough to detect WM perfusion signal and perfusion deficits...
  21. ncbi Functional and molecular evidence for impairment of calcium-activated potassium channels in type-1 diabetic cerebral artery smooth muscle cells
    Ling Dong
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Cereb Blood Flow Metab 28:377-86. 2008
    ..Diabetic mice show increased myogenic tone and decreased contraction in response to iberiotoxin in cerebral arteries and elevated blood pressure...
  22. ncbi Type V phosphodiesterase expression in cerebral arteries with vasospasm after subarachnoid hemorrhage in a canine model
    Satoshi Inoha
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurol Res 24:607-12. 2002
    ..PDE V expression was most prominent in smooth muscle cells following SAH. These results suggest that clinical administration of a PDE V inhibitor may be a useful therapeutic tool in the prevention of vasospasm following SAH...
  23. ncbi Two-compartment exchange model for perfusion quantification using arterial spin tagging
    J Zhou
    Department of Radiology, Johns Hopkins University Medical School, Baltimore, Maryland 21205-2195, USA
    J Cereb Blood Flow Metab 21:440-55. 2001
    ..FAIR flow values with correction for restricted exchange, however, correlate well with the radioactive microsphere flow values. The limitations of the approach in terms of choice of the intercompartmental exchange rates are discussed...
  24. ncbi Antagonism of R-type calcium channels significantly improves cerebral blood flow after subarachnoid hemorrhage in rats
    Fei Wang
    Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Neurotrauma 27:1723-32. 2010
    ....
  25. ncbi Flow territory mapping of the cerebral arteries with regional perfusion MRI
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 35:882-7. 2004
    ..angiography is the gold standard for visualization of the vascular tree supplied by the major cerebral arteries and assessment of collateral flow...
  26. ncbi Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries
    Scott Earley
    Department of Pharmacology, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT, USA
    Circ Res 95:922-9. 2004
    ..Several other of the approximately 22 identified TRP proteins are also present in cerebral arteries, but their functions have not been elucidated...
  27. ncbi Novel isoforms of NADPH-oxidase in cerebral vascular control
    Alyson A Miller
    Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
    Pharmacol Ther 111:928-48. 2006
    ..Studies have shown that Nox1, Nox2 (also known as gp91phox) and Nox4 are all expressed in cerebral arteries, suggesting that multiple isoforms of NADPH-oxidase may be important for ROS production by cerebral arteries...
  28. ncbi Damage within a network of white matter regions underlies executive dysfunction in CADASIL
    M O'SULLIVAN
    Clinical Neuroscience, St George s, University of London, UK
    Neurology 65:1584-90. 2005
    ....
  29. ncbi Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats
    Tomohiro Aoki
    Kyoto University, Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto, Japan
    Stroke 38:162-9. 2007
    ..Matrix metalloproteinases (MMPs) are a family of proteinases which are involved in the remodeling of vascular walls. In the present study, we investigated the significance of MMPs in the progression of cerebral aneurysms...
  30. pmc Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries
    Damodaran Narayanan
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis TN 38163, USA
    Circ Res 107:631-41. 2010
    ..Mitochondria can uptake calcium (Ca(2+)), but intracellular Ca(2+) signals that regulate mitochondrial Ca(2+) concentration ([Ca(2+)](mito)) and physiological functions of changes in [Ca(2+)](mito) in arterial myocytes are unclear...
  31. pmc Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke
    T Michael De Silva
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e28393. 2011
    Post-ischemic oxidative stress and vasomotor dysfunction in cerebral arteries may increase the likelihood of cognitive impairment and secondary stroke...
  32. ncbi Improvement in neurological outcome and abolition of cerebrovascular endothelin B and 5-hydroxytryptamine 1B receptor upregulation through mitogen-activated protein kinase kinase 1/2 inhibition after subarachnoid hemorrhage in rats
    Carl Christian Larsen
    Departments of Neurosurgery, Glostrup University Hospital, Glostrup, Denmark
    J Neurosurg 114:1143-53. 2011
    ..The aim in the present study was to determine whether treatment with the MEK1/2 inhibitor U0126 can prevent cerebrovascular receptor upregulation and improve functional outcome after experimental SAH in rats...
  33. pmc Beta-amyloid, blood vessels, and brain function
    Eric E Smith
    Division of Neurology, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 40:2601-6. 2009
    ..In this review, we discuss current evidence linking beta-amyloid metabolism with vascular function and morphological changes in animals and humans...
  34. ncbi Selective up-regulation of 5-HT(1B/1D) receptors during organ culture of cerebral arteries
    N L Hoel
    Department of Clinical Experimental Research, Glostrup University Hospital, Denmark
    Neuroreport 12:1605-8. 2001
    ..Therefore we investigated if these changes also applied for the vasoconstrictive 5-HT receptors. Rat cerebral arteries express 5-HT2 receptors...
  35. ncbi Effect of short-term phytoestrogen treatment in male rats on nitric oxide-mediated responses of carotid and cerebral arteries: comparison with 17beta-estradiol
    Christopher G Sobey
    Department of Pharmacology, The University of Melbourne, Parkville, Victoria, Australia
    J Pharmacol Exp Ther 310:135-40. 2004
    ..Isoflavone therapy may therefore be a feasible approach to protect against cerebrovascular disease and stroke...
  36. ncbi Comparison of experimental rat models of early brain injury after subarachnoid hemorrhage
    Jin Yul Lee
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Neurosurgery 65:331-43; discussion 343. 2009
    ..To investigate acute pathophysiological changes after subarachnoid hemorrhage (SAH) in rats and compare endovascular perforation and double blood injection models for studies of early brain injury after SAH...
  37. pmc Extracellular K(+)-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels
    H J Knot
    Department of Pharmacology, University of Vermont, Colchester, VT 05446 2500, USA
    J Physiol 492:419-30. 1996
    ..1. The hypothesis that inward rectifier K(+) channels are involved in the vasodilatation of small coronary and cerebral arteries (100-200 microm diameter) in response to elevated [K+]o was tested...
  38. ncbi Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms
    Tomohiro Aoki
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kawaharacho, Shogoin, Sakyo ku, Kyoto, Japan
    Stroke 38:2337-45. 2007
    ..We investigated the role of TIMPs in the progression of cerebral aneurysms in the present study...
  39. ncbi Association of the metabolic syndrome with intracranial atherosclerotic stroke
    O Y Bang
    Department of Neurology, School of Medicine, Ajou University, Suwon, South Korea
    Neurology 65:296-8. 2005
    ..005). The results suggest that treatment of metabolic abnormalities may be an important prevention strategy for intracranial atherosclerosis...
  40. ncbi Cerebral vascular dysfunction in TallyHo mice: a new model of Type II diabetes
    Sean P Didion
    Dept of Internal Medicine, The Univ of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 292:H1579-83. 2007
    ....
  41. ncbi Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, BMC A13, Lund University, 221 84 Lund, Sweden
    Stroke 39:185-90. 2008
    ..kinase (MAPK) and protein kinase C (PKC) subtypes in the pathophysiology of cerebral ischemia after SAH in cerebral arteries and microvessels and to examine temporal activation of the kinases...
  42. ncbi Immunotherapy reduces vascular amyloid-beta in PDAPP mice
    Sally Schroeter
    Elan Pharmaceuticals, South San Francisco, California 94080, and Wyeth Pharmaceuticals, Cambridge, Massachusetts 02140, USA
    J Neurosci 28:6787-93. 2008
    ..These observations raise the possibility that Abeta immunotherapy can potentially slow or halt the course of CAA development in AD that is implicated in vascular dysfunction...
  43. ncbi Effects of statins on the progression of cerebral white matter lesion: Post hoc analysis of the ROCAS (Regression of Cerebral Artery Stenosis) study
    Vincent C T Mok
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    J Neurol 256:750-7. 2009
    ..001) and simvastatin treatment (beta = -0.214, P = 0.043) independently predicted change in WML volume. Our findings suggest that statins may delay the progression of cerebral WML only among those who already have severe WML at baseline...
  44. ncbi Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species
    T Michael De Silva
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Stroke 40:1091-7. 2009
    ..We tested whether gender influences cerebrovascular responses to angiotensin II (AngII) and the role(s) of Nox2...
  45. ncbi NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2
    Alyson A Miller
    Dept of Pharmacology, Monash Univ, Clayton, Melbourne, Victoria 3800, Australia
    Am J Physiol Heart Circ Physiol 296:H220-5. 2009
    ..NADPH-stimulated superoxide (O(2)(-)) production by basilar, middle cerebral arteries (MCA), and common carotid arteries (CA) and thoracic aorta (AO) from rat, mouse, rabbit, and pig was ..
  46. ncbi Differences in anatomical distribution, gender, and sidedness between ruptured and unruptured intracranial aneurysms in a defined patient population
    Mads Aarhus
    Department of Surgical Sciences, University of Bergen, Norway
    Acta Neurochir (Wien) 151:1569-74. 2009
    ..The aim of the study was to examine the anatomical distribution of ruptured and unruptured intracranial aneurysms in a defined population...
  47. ncbi NF-kappaB activation plays a role in superoxide-mediated cerebral endothelial dysfunction after hypoxia/reoxygenation
    Hui Xie
    Department of Neonatology, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
    Stroke 36:1047-52. 2005
    ....
  48. ncbi Impaired endothelium-dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes
    Sean P Didion
    Department of Internal Medicine, University of Iowa Carver College of Medicine Iowa City, IA 52242, USA
    Stroke 36:342-7. 2005
    ..The goals of this study were to examine the role of superoxide in impaired endothelium-dependent responses and to examine the influence of Rho-kinase on vascular tone in the cerebral microcirculation in type II diabetes...
  49. ncbi Subarachnoid hemorrhage induces enhanced expression of thromboxane A2 receptors in rat cerebral arteries
    Saema Ansar
    Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Sweden
    Brain Res 1316:163-72. 2010
    ..the involvement of thromboxane A(2) receptors (TP) in the pathophysiology of cerebral ischemia after SAH in cerebral arteries. SAH was induced in rats by injecting 250 microl of blood into the prechiasmatic cistern...
  50. ncbi Vessel-encoded arterial spin-labeling using pseudocontinuous tagging
    Eric C Wong
    Department of Radiology, University of California, San Diego, La Jolla, CA, USA
    Magn Reson Med 58:1086-91. 2007
    ..High SNR maps of left carotid, right carotid, and basilar territories are generated in 6 min of scan time...
  51. ncbi NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke
    Alyson A Miller
    Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
    Brain Res 1111:111-6. 2006
    ..We tested whether activity of the superoxide-generating enzyme, NADPH-oxidase, is enhanced in cerebral arteries within, adjacent and distant from the ischemic core...
  52. pmc Statins and selective inhibition of Rho kinase protect small conductance calcium-activated potassium channel function (K(Ca)2.3) in cerebral arteries
    Alister J McNeish
    Reading School of Pharmacy, University of Reading, Reading, Berkshire, United Kingdom
    PLoS ONE 7:e46735. 2012
    ..In cerebral arteries, K(Ca)2.3 loss is associated with NO synthase inhibition, but is restored if TP receptors are blocked...
  53. ncbi Loss of CO2-induced distensibility in cerebral arteries with chronic hypertension or vasospasm after subarachnoid hemorrhage
    Seiji Nakajima
    Department of Neurosurgery, Graduate School of Medicine, Kobe University, Kobe, Japan
    Kobe J Med Sci 53:317-26. 2007
    ..ICA in WKY and both BA and ICA in SHR were unchanged in wall thickness before and after SAH. High quality angiography demonstrated deteriorated distensibility in chronic hypertension or SAH-induced spastic vessels...
  54. ncbi Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Blood 103:2624-9. 2004
    ..These findings demonstrate that the Mthfr(+/-) genotype sensitizes mice to diet-induced hyperhomocysteinemia and that hyperhomocysteinemia alters tissue methylation capacity and impairs endothelial function in cerebral microvessels...
  55. ncbi Alkaline pH shifts Ca2+ sparks to Ca2+ waves in smooth muscle cells of pressurized cerebral arteries
    Thomas J Heppner
    Department of Pharmacology, University of Vermont College of Medicine, Burlington 05405 0068, USA
    Am J Physiol Heart Circ Physiol 283:H2169-76. 2002
    ..These findings indicate that alkaline pH-induced Ca(2+) waves originate from ryanodine receptors and make a minor, direct contribution to alkaline pH-induced vasoconstriction...
  56. ncbi Vascular smooth muscle actin cytoskeleton in cerebral artery forced dilatation
    M J Cipolla
    Department of Surgery, Oregon Health Sciences University, Portland 97201, USA
    Stroke 29:1223-8. 1998
    We investigated the role of actin polymerization in regulating arterial diameter in response to increasing pressure and modulating forced dilatation of cerebral arteries at pressures above the upper limit of autoregulation.
  57. pmc Notch-1 signalling is activated in brain arteriovenous malformations in humans
    Qichuan ZhuGe
    Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical College, Wenzhou, China
    Brain 132:3231-41. 2009
    ....
  58. ncbi Multiphase pseudocontinuous arterial spin labeling (MP-PCASL) for robust quantification of cerebral blood flow
    Youngkyoo Jung
    Center for Functional MRI and Department of Radiology, University of California San Diego, La Jolla, California 92093, USA
    Magn Reson Med 64:799-810. 2010
    ..Our results show that multiple phase offset PCASL provides robust cerebral blood flow quantification while retaining much of the sensitivity advantage of PCASL...
  59. pmc Measurement of T1 of human arterial and venous blood at 7T
    Swati D Rane
    Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
    Magn Reson Imaging 31:477-9. 2013
    ....
  60. ncbi The response to rapid infusion of fentanyl in the human brain measured using pulsed arterial spin labelling
    Fernando O Zelaya
    Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    MAGMA 25:163-75. 2012
    ..v.) infusion of an opioid agonist (fentanyl) and an opioid antagonist (naloxone)...
  61. ncbi beta(1)-Subunit of BK channels regulates arterial wall[Ca(2+)] and diameter in mouse cerebral arteries
    M Lohn
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Charite University Hospitals, Humboldt University of Berlin, D 13125 Berlin, Germany
    J Appl Physiol 91:1350-4. 2001
    ..effects of inhibitors of ryanodine receptor and BK channels on the global [Ca(2+)](i) and diameter of small cerebral arteries pressurized to 60 mmHg...
  62. pmc Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels
    Sulayma Albarwani
    Department of Physiology, College of Medicine, Sultan Qaboos University, Al Khod, Sultanate of Oman
    J Physiol 551:751-63. 2003
    ..evaluate the contribution of KV1 family channels to the resting membrane potential and diameter of small rat cerebral arteries, and to identify the alpha-subunit composition of these channels using patch-clamp, molecular and ..
  63. ncbi The supratentorial arteries
    Albert L Rhoton
    Department of Neurological Surgery, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610 0265, USA
    Neurosurgery 51:S53-120. 2002
  64. pmc Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries
    Christiane Wirrig
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    J Cereb Blood Flow Metab 31:212-21. 2011
    ..In rat cerebral arteries, SPC but not S1P activated p38 mitogen-activated protein kinase (MAPK)...
  65. ncbi Visualization of intracerebral arteries by synchrotron radiation microangiography
    K Myojin
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    AJNR Am J Neuroradiol 28:953-7. 2007
    ..The goal of our study was the development of methodology allowing visualization of small cerebral arteries in rodents, suitable for experimental models.
  66. pmc Determination of spin compartment in arterial spin labeling MRI
    Peiying Liu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 65:120-7. 2011
    ..The arterial blood volume was calculated to be 1.18 ± 0.21 mL/100 g. A postlabeling delay time of 2 s is sufficient to allow the spins to completely enter the tissue space for gray matter but not for white matter...
  67. ncbi Dual vessel arterial spin labeling scheme for regional perfusion imaging
    Ivan Zimine
    Department of Neuroradiology, National Neuroscience Institute, Singapore
    Magn Reson Med 56:1140-4. 2006
    ..The new approach was tested on seven healthy volunteers and compared to the original labeling scheme. The results showed that the same perfusion territories and regional CBF values can be obtained...
  68. ncbi Minimizing acquisition time of arterial spin labeling at 3T
    Maria A Fernandez-Seara
    Neuroimaging Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Magn Reson Med 59:1467-71. 2008
    ..It is shown that perfusion measurements obtained in less than 1 min of scan time are reproducible, with a coefficient of variation of 7%. The perfusion maps generated from these data can be used to characterize the stroke lesion...
  69. ncbi Efficient visualization of vascular territories in the human brain by cycled arterial spin labeling MRI
    Matthias Gunther
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Heidelberg, Germany
    Magn Reson Med 56:671-5. 2006
    ..3+/-2.4 and 15.3+/-5.1, respectively. An optimized setup was achieved by combining the regional labeling scheme with an efficient readout technique, which yielded a total measurement time of 2 min for three vascular territories...
  70. ncbi Identification of the characteristic vascular changes in a sural nerve biopsy of a case with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
    J M Schroder
    Institute of Neuropathology, Medical Faculty, Technical University Aachen, Germany
    Acta Neuropathol 89:116-21. 1995
    ..Occasional focal accumulation of pinocytotic vesicles opposite the granular deposits suggests exocytosis as one of the possible pathomechanisms for their production...
  71. ncbi Maturation alters cyclic nucleotide and relaxation responses to nitric oxide donors in ovine cerebral arteries
    Surya M Nauli
    Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif 92350, USA
    Biol Neonate 83:123-35. 2003
    To examine the hypothesis that maturation modulates nitric oxide (NO)-induced relaxation in cerebral arteries, we quantified concentration-relaxation relations and the corresponding dynamic responses of guanosine 3':5'-cyclic ..
  72. ncbi L-type Ca2+ channels in fetal and adult ovine cerebral arteries
    Arlin B Blood
    Center for Perinatal Biology, Department of Physiology Pharmacology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 282:R131-8. 2002
    Recently, we reported that, whereas in cerebral arteries of the adult a majority of norepinephrine (NE)-induced increase in intracellular Ca2+ concentration ([Ca2+]i) comes from release of the sarcoplasmic reticulum (SR) Ca2+ stores, in ..
  73. ncbi Kv2 channels oppose myogenic constriction of rat cerebral arteries
    Gregory C Amberg
    Dept of Physics and Biophysics, Univ of Washington, PO Box 357290, Seattle, WA 98195, USA
    Am J Physiol Cell Physiol 291:C348-56. 2006
    ..In this study, we tested the hypothesis Kv2 channels may also significantly regulate tone of rat cerebral arteries. We found that Kv2.1 transcript and protein are present in cerebral arterial smooth muscle...
  74. ncbi Bimodal effects of fluoxetine on cerebral nitrergic neurogenic vasodilation in porcine large cerebral arteries
    Mei Fang Chen
    Department of Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Neuropharmacology 62:1651-8. 2012
    Fluoxetine-induced relaxation of the smooth muscle of small cerebral arteries is thought beneficial in treating mental disorders...
  75. ncbi The effect of i.v. L-NG methylarginine hydrochloride (L-NMMA: 546C88) on basal and acetazolamide (Diamox) induced changes of blood velocity in cerebral arteries and regional cerebral blood flow in man
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Cephalalgia 25:344-52. 2005
    ..The percentage increase of V(mean) was 1.5 times that of rCBF (n = 8). Our data suggest that the basal tone of human cerebral arterioles but not of conduit arteries is NO-dependent. The action of acetazolamide in man is not NO-dependent...
  76. ncbi Histamine-induced depolarization: ionic mechanisms and role in sustained contraction of rabbit cerebral arteries
    N I Gokina
    Department of Pharmacology, College of Medicine, The University of Vermont, Burlington 05405, USA
    Am J Physiol Heart Circ Physiol 278:H2094-104. 2000
    ....
  77. ncbi A novel haemodynamic cerebral aneurysm model of rats with normal blood pressure
    Jun Cai
    Department of Neurosurgery, Shanghai Tenth People s Hospital, Tongji University School of Medicine, 301 Middle YanChang Road, Shanghai, China
    J Clin Neurosci 19:135-8. 2012
    ..To evaluate the morphological changes of the cerebral arteries, synchrotron radiation angiography was utilised at 1 month, 2 months and 3 months after induction...
  78. pmc Maturation and the role of PKC-mediated contractility in ovine cerebral arteries
    Ravi Goyal
    Department of Physiology, Center for Perinatal Biology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 297:H2242-52. 2009
    ..produced a robust contractile response, which was increased a further 20 to 30% by U-0126 (MEK inhibitor) in cerebral arteries of both age groups...
  79. ncbi Human endothelin subtype A receptor enhancement during tissue culture via de novo transcription
    Jacob Hansen-Schwartz
    Department of Clinical Experimental Research, Glostrup Hospital, DK 2600 Glostrup, Denmark
    Neurosurgery 50:127-33; discussion 133-5. 2002
    ..We present data that indicate an inherent capacity of human cerebral arteries to change their sensitivity to ET.
  80. pmc uPA impairs cerebrovasodilation after hypoxia/ischemia through LRP and ERK MAPK
    William M Armstead
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Res 1231:121-31. 2008
    ..These data suggest that modulation of uPA upregulation and/or uPA-mediated signal transduction may preserve cerebrohemodynamic control after hypoxia/ischemia...
  81. pmc The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat
    Aida Maddahi
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    J Neuroinflammation 8:107. 2011
    ..Secondly, we asked if the expression was regulated via activation of the MEK-ERK1/2 pathway...
  82. pmc Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel
    Diansan Su
    Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
    Anesthesiology 114:374-9. 2011
    ..In the current study, we hypothesized that salvinorin A dilates pial arteries via activation of nitric oxide synthase, adenosine triphosphate-sensitive potassium channels, and opioid receptors...
  83. ncbi Enhanced myogenic tone in cerebral arteries from a rabbit model of subarachnoid hemorrhage
    Masanori Ishiguro
    Department of Pharmacology, Division of Neurological Surgery, University of Vermont College of Medicine, Burlington 05405 0068, USA
    Am J Physiol Heart Circ Physiol 283:H2217-25. 2002
    ..Currently, little is known regarding the impact of SAH on small diameter (100-200 microm) cerebral arteries, which play an important role in the autoregulation of cerebral blood flow...
  84. pmc Ryanodine receptors regulate arterial diameter and wall [Ca2+] in cerebral arteries of rat via Ca2+-dependent K+ channels
    H J Knot
    Department of Pharmacology, Given Building, The University of Vermont, Burlington, VT 05405, USA
    J Physiol 508:211-21. 1998
    ..KCa) channels on the membrane potential, intracellular [Ca2+], and diameters of small pressurized (60 mmHg) cerebral arteries (100-200 micron) were studied using digital fluorescence video imaging of arterial diameter and wall [Ca2+], ..
  85. pmc Doppler study of cerebral arteries in hypercholesterolemia
    Mehdi Farhoudi
    Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Vasc Health Risk Manag 7:203-7. 2011
    ..Although transcranial Doppler (TCD) studies of the cerebral arteries are indicative of decreased cerebral blood flow velocities in patients with hypercholesterolemia, the number ..
  86. ncbi Arachidonic acid metabolites, hydrogen peroxide, and EDHF in cerebral arteries
    Junping You
    Cerebrovascular Research Laboratory, Department of Anesthesiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 289:H1077-83. 2005
    We tested the hypotheses that EDHF in rat middle cerebral arteries (MCAs) involves 1) metabolism of arachidonic acid through the epoxygenase pathway, 2) metabolism of arachidonic acid through the lipoxygenase pathway, or 3) reactive ..
  87. ncbi TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries
    S A Reading
    Department of Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Heart Circ Physiol 288:H2055-61. 2005
    ..with antisense oligodeoxynucleotides significantly decreased the depolarization and constriction of intact cerebral arteries in response to UTP...
  88. ncbi EP1- and EP3-receptors mediate prostaglandin E2-induced constriction of porcine large cerebral arteries
    Vikram Jadhav
    Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield, Illinois 62794 9629, USA
    J Cereb Blood Flow Metab 24:1305-16. 2004
    ..therefore, was designed to examine the receptor mechanisms involved in PGE2-induced constriction of large cerebral arteries in the adult pig...
  89. ncbi The phosphodiesterase 3 inhibitor cilostazol dilates large cerebral arteries in humans without affecting regional cerebral blood flow
    Steffen Birk
    Danish Headache Center and Department of Neurology, University of Copenhagen, Glostrup University Hospital, Glostrup, Copenhagen, Denmark
    J Cereb Blood Flow Metab 24:1352-8. 2004
    ..Mean flow velocity in the middle cerebral arteries (VMCA) was measured with transcranial Doppler, and the superficial temporal and radial arteries diameters ..
  90. ncbi Mice with a deletion in the first intron of the Col1a1 gene develop dissection and rupture of aorta in the absence of aneurysms: high-resolution magnetic resonance imaging, at 4.7 T, of the aorta and cerebral arteries
    J Marjamaa
    Neurosurgery Research Group, Biomedicum, Helsinki, Finland
    Magn Reson Med 55:592-7. 2006
    ..b>Cerebral arteries were imaged using a three-dimensional time of fight pulse sequence...
  91. ncbi In vivo stimulatory effect of erythropoietin on endothelial nitric oxide synthase in cerebral arteries
    Anantha Vijay R Santhanam
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 291:H781-6. 2006
    ..Our studies suggest that in cerebral circulation, Epo enhances endothelium-dependent vasodilatation mediated by NO. This effect could play an important role in the vascular protective effect of Epo...
  92. pmc Endothelin receptors mediating contraction in goat cerebral arteries
    J B Salom
    , Hospital Universitario La Fe, Spain
    Br J Pharmacol 109:826-30. 1993
    ..the subtype of receptor mediating contraction to endothelin-1 and sarafotoxin S6b in goat isolated middle cerebral arteries. 2...
  93. ncbi Gender and risk factor dependence of cerebral blood flow velocity in Chinese adults
    Puhong Zhang
    Department of Epidemiology, Cardiovascular Institute, Fuwai Hospital, Chinese Academy of Medical Sciences, 167 Beilishilu, Beijing 100037, China
    Brain Res Bull 69:282-7. 2006
    ..The objective of this study is to determine if and how cerebral blood flow velocity and stroke risk factors are related in a stroke free population...
  94. ncbi Peroxynitrite diminishes myogenic activity and is associated with decreased vascular smooth muscle F-actin in rat posterior cerebral arteries
    Matthew J Maneen
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Stroke 37:894-9. 2006
    This study investigated the effect of peroxynitrite (ONOO-) on pressure-induced myogenic activity and vascular smooth muscle (VSM) actin of isolated posterior cerebral arteries (PCAs).
  95. ncbi Evidence for two-pore domain potassium channels in rat cerebral arteries
    Robert M Bryan
    Department of Anesthesiology, Baylor College of Medicine, University of Houston, Houston, Texas 77030, USA
    Am J Physiol Heart Circ Physiol 291:H770-80. 2006
    ..We conclude that AA dilates the rat MCA and increases K+ currents in VSMCs via an atypical K+ channel that is likely a member of the K(2P) channel family...
  96. ncbi Novel vasodilatory effect of intracisternal injection of magnesium sulfate solution on spastic cerebral arteries in the canine two-hemorrhage model of subarachnoid hemorrhage
    Kentaro Mori
    Department of Neurosurgery, Shizuoka Hospital, Shizuoka, Japan
    J Neurosurg 110:73-8. 2009
    ..The extracellular Mg++ has a vasodilatory effect on the cerebral artery. The present study investigated the effect of intracisternal injection of MgSO4 solution on cerebral vasospasm in a canine model of subarachnoid hemorrhage (SAH)...
  97. ncbi 17beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilation
    Jose A Ospina
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Am J Physiol Heart Circ Physiol 285:H241-50. 2003
    ..Middle cerebral arteries were isolated from ovariectomized female Fischer-344 rats with or without chronic in vivo 17beta-estradiol ..
  98. ncbi Expression of ET(A) and ET(B) receptor mRNA in human cerebral arteries
    J Hansen-Schwartz
    Department of Clinical Experimental Research, Glostrup University Hospital, Denmark
    Br J Neurosurg 16:149-53. 2002
    ..ET(B) receptor mRNA using the reverse transcription polymerase chain reaction (RT-PCR) in both normal human cerebral arteries and cerebral arteries from patients with cerebrovascular disease...
  99. ncbi Altered structure of small cerebral arteries in patients with essential hypertension
    Damiano Rizzoni
    Clinica Medica, Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    J Hypertens 27:838-45. 2009
    ..Alterations in the structure of small cerebral arteries have been demonstrated in animal models of experimental or genetic hypertension...
  100. ncbi S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate
    Salvatore Salomone
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, CNY 149 13th Street, Room 6403, Charlestown, MA 02129, USA
    Eur J Pharmacol 469:125-34. 2003
    ..of S1P, indicating that S1P(3) receptors account for at least part of S1P-mediated vasoconstriction in cerebral arteries. In vivo, intracarotid injection of S1P decreased cerebral blood flow, an effect prevented by suramin ..
  101. ncbi Alteration in contractile G-protein coupled receptor expression by moist snuff and nicotine in rat cerebral arteries
    Hardip Sandhu
    Department of Clinical Experimental Research, Glostrup Research Institute, Ndr Ringvej 69, 2600 Glostrup, Denmark
    Toxicol Appl Pharmacol 252:138-49. 2011
    ..receptors (GPCR), such as endothelin ET(B), serotonin 5-HT(1B), and thromboxane A(2) TP receptors, in rat cerebral arteries. Studies show that these vasocontractile GPCR show alterations by lipid-soluble cigarette smoke particles ..

Research Grants65

  1. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..Middle cerebral arteries from 5 autopsies and surgically resected cerebral cortex from 10 epilepsy patients will be used as control...
  2. (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION: FETUS AND ADULT
    Lawrence D Longo; Fiscal Year: 2013
    ..In cerebral arteries, we will test hypotheses regarding Oi-adrenergic-mediated signal transduction mechanisms for both Ca^*-..
  3. Calcium channels in arterial smooth muscle cells
    Jonathan H Jaggar; Fiscal Year: 2013
    ..This proposal stems from preliminary data which suggest that myocytes of resistance-size cerebral arteries express a novel CaV1.2 11 subunit splice variant that is uniquely modulated by the auxiliary 124 subunit...
  4. Potassium Channel Dysfunction in Cerebral Arteries
    David W Busija; Fiscal Year: 2013
    ..Furthermore, many of the initial elements of the insulin signaling cascade in cerebral arteries are similar to those that we have found to promote neuronal preconditioning;leading to speculation that ..
  5. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    ..metalloproteinases (MMPs) which can cleave endothelin-1 into fragments that can subsequently cause spasm of cerebral arteries. Our second aim is to correlate SAH-related disability with white blood cells'release of MMPs and their ..
  6. Role of BK subunits in ethanol-cholesterol synergistic inhibition of BK channel
    Anna Bukiya; Fiscal Year: 2011
    ..Cerebrovascular ischemia results from impaired vasodilation and/or enhanced constriction of cerebral arteries. The activity of large-conductance, calcium- and voltage-gated (BK) channels critically limits vascular ..
  7. Cellular Mechanisms of Vasoregulation by Volatile Anesthetics
    Rostislav Bychkov; Fiscal Year: 2012
    ..This is a novel finding that positions K2P channels as potential targets of inhalation anesthetics in cerebral arteries. Our overall working hypothesis is that volatile anesthetics activate K2P channels in vascular myocytes and ..
  8. TRP Channel-Dependent Regulation of Arterial Tone
    Scott Earley; Fiscal Year: 2013
    ..These experiments will utilize intact cerebral arteries for intracellular microelectrode recordings of smooth muscle membrane potential confocal Ca2+ imaging, and ..
  9. Preclinical Alzheimer's Disease Biomarkers: Effects of Midlife Vascular Factors
    WHITNEY LEE WHARTON; Fiscal Year: 2013
    ..e. pulse-wave velocity and flow mediated vasodilation). CBF will be assessed in the middle and posterior cerebral arteries, bilaterally...
  10. Vasodilation via selective pharmacological targeting of BK channel beta1 subunits
    Alex M Dopico; Fiscal Year: 2013
    ..Given the high prevalence of disease requiring acute dilation of both mesenteric and cerebral arteries, we focus on 3rd-4th branches of mesenteric artery and resistance-size, middle cerebral artery...
  11. Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging
    Farzaneh A Sorond; Fiscal Year: 2010
    ..TCD procedures routinely used in our laboratory allow us to assess these hypotheses as they relate to the cerebral arteries of humans, a field in which our knowledge is most deficient...
  12. Vascular control by K+ channel trafficking
    Jonathan H Jaggar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Small (resistance-size) cerebral arteries and arterioles control regional brain blood flow, thereby providing neurons and other brain cells with necessary oxygen and nutrients...
  13. Signaling Mechanisms in Myogenic Tone of Skeletal Muscle Arterioles: Role of BKCa
    Michael A Hill; Fiscal Year: 2012
    ..This hypothesis is largely based on studies performed in small cerebral arteries, however our work does not support an identical role for BKCa in regulating myogenic tone of skeletal muscle ..
  14. PSD95 scaffolding of vascular K+ channels in hypertension
    Sung W Rhee; Fiscal Year: 2013
    ..K+ (KV1) channels are an important determinant of the resting membrane potential and diameter of small cerebral arteries. During hypertension, KV1 channel-mediated dilation appears to be blunted and is postulated to increase ..
  15. Variation in platelet function: the genetics of platelet gene expression
    Paul F Bray; Fiscal Year: 2013
    ..variation in human platelet reactivity, which likely contributes to occlusion of coronary and cerebral arteries upon atherosclerotic plaque rupture in some individuals, whereas other individuals repair the wound without ..
  16. Effects of obstructive sleep apnea on cerebral circulation
    Robert M Bryan; Fiscal Year: 2013
    ..We propose that ROS and endothelin act in a pathological cycle to produce a hypercontractile phenotype in cerebral arteries and arterioles...
  17. Cerebrovascular Myosin Light Chain Phosphorylation in Fetus, Newborn, and Adult
    William J Pearce; Fiscal Year: 2013
    ..Compared to adult arteries, immature cerebral arteries exhibit greater reliance on Ca++ influx than on intracellular Ca++ release for initiation of contraction, ..
  18. Endothelial Dysfunction in Insulin Resistance
    David W Busija; Fiscal Year: 2010
    ..We will test the hypothesis that IR impairs endothelium- and VSM potassium channel-dependent function of cerebral arteries via vascular production and actions of ROS...
  19. Mitochondrial Influences on Cerebral Arteries
    David W Busija; Fiscal Year: 2013
    ..and/or augment the release of ROS from mitochondria activate signaling pathways leading to net dilation of cerebral arteries. Furthermore, our preliminary data indicate that mitochondrial influences are adversely affected by insulin ..
  20. Mechanisms of Endothelial Cell Hyperpolarization
    Sean P Marrelli; Fiscal Year: 2012
    ..the role of TRP channels in IKCa channel activation, EC hyperpolarization, and EDHF-mediated dilation in cerebral arteries. EDHF-mediated dilation of cerebral arteries requires EC Ca2+ influx, IKCa channel activation, and EC ..
  21. Cerebral Autoregulation Monitoring to Reduce Brain Injury from Cardiac Surgery
    OLA ARVID SELNES; Fiscal Year: 2013
    ..additional aim of the study will be to assess whether preoperative transcranial Doppler examination of major cerebral arteries can identify patients who are prone to the composite neurological end-point...
  22. Vasoregulation by the Cav1.2 channel C-terminus
    Kirk W Evanson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Resistance-size cerebral arteries modulate brain regional blood pressure and flow. Arterial smooth muscle cell voltage-dependent calcium (CaV1.2) channels are key regulators of vascular contractility...
  23. Role of TRP channels and calcium signaling in cerebral arteries.
    ALBERT LOUIS GONZALES; Fiscal Year: 2011
    ..The proposed study will provide a novel molecular mechanism, as well as exciting potential targets for the development of novel treatments. ..
  24. Control of Cerebral Blood Flow by KCa2 and KCa3
    Robert M Bryan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A novel endothelium-dependent dilator mechanism was identified in cerebral arteries and arterioles...
  25. Vasoregulation by IP3 receptor coupling to TRPC channels
    Adebowale Adebiyi; Fiscal Year: 2013
    ..IP3R to TRPC3 coupling mediates IP3-induced membrane depolarization, [Ca2+]i elevation, and constriction in cerebral arteries. Aim 3 will examine the hypothesis that arterial myocyte caveolae mediate physical and functional coupling ..
  26. Diffusion weighted imaging Evaluation For Understanding Stroke Evolution2:DEFUSE
    Gregory W Albers; Fiscal Year: 2010
    ..The success of tPA therapy is attributed to the medication's ability to open occluded cerebral arteries before irreversible brain injury has occurred...
  27. Arterial Smooth Muscle Chloride Channels
    Jonathan H Jaggar; Fiscal Year: 2013
    ..b>Cerebral arteries are major resistance vessels critical for control of brain regional blood flow...
  28. Flow Divertors to Cure Cerebral Aneurysms
    Baruch B Lieber; Fiscal Year: 2012
    ..a small incision in the groin area (no need for open brain surgery) and navigated through a catheter into cerebral arteries to treat brain aneurysms...
  29. MELATONIN AND CEREBRAL BLOOD FLOW AUTOREGULATION
    Mohan Viswanathan; Fiscal Year: 2000
    ..Recent studies demonstrate that high affinity melatonin receptors are also present in cerebral arteries and that melatonin is capable of causing constriction of these arteries...
  30. MECHANISMS OF HYPOXIC CEREBRAL VASODILATATION IN NEWBORN
    William Pearce; Fiscal Year: 1992
    ..that the vascular endothelium makes a greater contribution to hypoxic relaxation in adult than in newborn cerebral arteries. Because previous studies by the applicant suggest that the endothelium of adult cerebral arteries plays an ..
  31. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2005
    ..In this proposal, we will focus on the molecular mechanisms of vascular adaptation in coronary and cerebral arteries and arterioles, and the associated integrated manifestations in vessel morphology and function at the ..
  32. Cerebral artery Ca2+ signaling & subarachnoid hemorrhage
    George Wellman; Fiscal Year: 2009
    ..in Ca2+ signaling and voltage-dependent Ca2+ channel (VDCC) properties lead to enhanced constriction of cerebral arteries in an established rabbit SAH model...
  33. New roles of Src tyrosine kinases in vascular tone
    LIGIA TORO DE STEFANI; Fiscal Year: 2007
    ..in smooth muscle cells from blood vessels subject to thrombotic episodes, like aorta, coronary, and cerebral arteries. Src tyrosine kinases (classical regulators of cell migration and differentiation) are emerging as new ..
  34. COCAINE AND PERINATAL CEREBRAL AND UMBILICAL VESSELS
    Michael Schreiber; Fiscal Year: 1992
    ..This may alter the response of the cerebral arteries to various stimuli...
  35. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 2002
    ..apposition of adrenergic and nonadrenergic/NOergic nerve terminals has been frequently observed in large cerebral arteries from different species...
  36. MECHANISM AND THERAPY OF CEREBROVASCULAR SPASM
    Thomas Duff; Fiscal Year: 1992
    ..In its strict sense CVS consists of severe, sustained narrowing of the lumen of cerebral arteries and usually has its onset five to ten days after SAH...
  37. Sphingosine 1 Phosphate and Embolic Stroke
    Christian Waeber; Fiscal Year: 2003
    ..preliminary data by showing that the high expression of S1P phosphatase (S1PP) mRNA in peripheral, but not cerebral arteries, is paralleled by a high [32P]S1P degrading activity with an inhibition profile corresponding to that of ..
  38. Hutchinson Gilford Progeria Syndrome and Atherosclerosis
    Stephen Young; Fiscal Year: 2009
    ..merciless disease;death occurs on average at age 13, nearly always from atherosclerosis in the coronary and cerebral arteries. A recent NIH workshop on HGPS concluded that a thorough understanding of vascular disease in HGPS syndrome ..
  39. Serum fatty acids and ischemic stroke in women
    Ka He; Fiscal Year: 2009
    ..One explanatory hypothesis for the paradoxical observations is that arteriosclerosis in different types of cerebral arteries has different causal patterns...
  40. Rheolytic Thrombectomy for Treatment of Ischemic Stroke
    Cindy Setum; Fiscal Year: 2001
    ..rheolytic catheter--NV150-- has been designed with adequate diameter, length and flexibility to access the cerebral arteries. Animal studies demonstrated that the NV150 catheter could be delivered to target arterial segments and ..
  41. COGNITIVE AND NEUROIMAGING STUDY OF SICKLE CELL ANEMIA
    Elias Melhem; Fiscal Year: 2001
    ..parenchymal perfusion to test the hypothesis that as cerebral blood flow velocity in the individual major cerebral arteries increases, perfusion at the arteriolar/capillary level will decrease; (2) examine the relationship between ..
  42. Cerebral Microvascular Endothelin Production
    Momoh Yakubu; Fiscal Year: 2003
    ..is prominent, and characterized by impaired vasodilator and increased vasoconstrictor mechanisms in cerebral arteries. Several factors may contribute to the observed alterations of pial arteriolar reactivity...
  43. Maturation and myogenic reactivity of cerebral arteries
    John Buchholz; Fiscal Year: 2005
    We have shown that maturation increases the magnitude and sensitivity of myogenic reactivity in neonatal cerebral arteries compared to adult mice...
  44. CELLULAR CONTROL MECHANISMS OF CEREBROVASCULAR TONE
    David Harder; Fiscal Year: 1999
    ..Isolated, cannulated cerebral arteries subjected to increasing levels of transmural pressure develop active tone, and constrict as pressure is ..
  45. CEREBAL ARTERIAL ADVENTITIA AND VASOSPASM
    ZVONIMIR KATUSIC; Fiscal Year: 2001
    ..We hypothesize that increased biosynthesis of nitric oxide in adventitia of cerebral arteries may cause vasodilatation and prevent development of vasospasm...
  46. Vascular Biomechanics in Traumatic Brain Injury
    Geoffrey Manley; Fiscal Year: 2006
    ..Recent work by our group has defined the longitudinal mechanical properties of human cerebral arteries and veins...
  47. VASOACTIVE DRUGS AND NEONATAL CEREBROVASCULAR REACTIVITY
    DANILYN ANGELES; Fiscal Year: 2004
    ..organ and tissue donation, the present proposal explores the specific hypothesis that exposure of immature cerebral arteries to commonly administered vasoactive pharmaceuticals during the neonatal period alters acute and long-term ..
  48. SRF/MYOCD: new targets in Alzheimer's neurovasculature
    JOSEPH MIANO; Fiscal Year: 2006
    ..an over-abundance of two interactive transcription factors in vascular smooth muscle cells (VSMC) from pial cerebral arteries of patients with AD which critically regulate CBF...
  49. EFFECTS OF O2 RADICALS AND PERIVASCULAR NERVES IN TRAUMA
    DOUGLAS DEWITT; Fiscal Year: 2009
    ..that inhibitors of gap junctions (GJ) attenuate myogenic tone and acetylcholine-mediated vasodilation in cerebral arteries suggests that GJ communication between vascular endothelial and smooth muscle cells plays an important role ..
  50. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2005
    ..4) defining the time course of changes in and the immunohistochemical locations of the 3 isoforms of NOS in cerebral arteries and perivascular blood clot after SAH in monkeys...
  51. PATHOPHYSIOLOGY OF BLOOD INDUCED CEREBRAL ARTERIOPATHY
    Marc Mayberg; Fiscal Year: 1991
    ..recent clinical and experimental evidence has demonstrated ultrastructural changes in the wall of cerebral arteries exposed to subarachnoid blood, which correspond temporally the the development of angiographic and clinical ..
  52. NEUROGENIC VASODILATION--MEDIATORS AND MECHANISMS
    Joseph Brayden; Fiscal Year: 1993
    ..whether endothelium-dependent hyperpolarization, which is transient in systemic arteries, is sustained in cerebral arteries due to intrinsic properties of the cerebral vascular smooth muscle cells or is a result of unique actions of ..
  53. Venoarterial ECMO and neonatal cerebrovascular injury
    Billie Short; Fiscal Year: 2004
    ..of newborn lambs to 2 hours of VA ECMO or hypoxia decreases the basal production of nitric oxide (NO) in cerebral arteries. The present proposal is to understand the mechanisms for this functional impairment...
  54. MAXIK CHANNELS IN AGING CORONARY SMOOTH MUSCLE
    LIGIA TORO DE STEFANI; Fiscal Year: 2003
    ..We and others have shown that KCa channels set the level of smooth muscle contractility in cerebral arteries and myometrium...
  55. CEREBRAL ARTERY REACTIVITY IN HYPERTENSION
    George Osol; Fiscal Year: 1992
    ..A new video-electronic technique will be used in which cerebral arteries ranging in diameter from 25 to 300 mum are cannulated, pressurized and perfused...
  56. MYOGENIC PROPERTIES OF CEREBRAL ARTERIES IN HYPERTENSION
    George Osol; Fiscal Year: 1991
    ..This study will add to our understanding of intrinsic events within the vessel wall itself which can result in hypertension-induced blood brain barrier breakdown, stroke and encephalopathy...
  57. ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2007
    ..controls without AD, and established a positive correlation between the degree of atherosclerotic disease of cerebral arteries in AD patients and neuropathological features typical for AD...
  58. Mechanisms Regulating Cerebral Blood Flow
    David Harder; Fiscal Year: 2009
    ..vascular tone, functional hyperemia and angiogenesis in the brain by regulating K+ channel activity in the cerebral arteries. This renewal application builds upon the outstanding progress and accomplishments made over the last 4 ..
  59. Role of Cerebrovascular K+ Channels in Hypertension
    NANCY RUSCH; Fiscal Year: 2005
    ..Notably, this vasoconstriction is regarded as a fundamental adaptive response of small cerebral arteries to the development of high blood pressure in vivo, which minimizes the damaging transmission of the high ..
  60. Mechanisms of resistance artery contraction
    JOSEPH ELLIOTT BRAYDEN; Fiscal Year: 2010
    ..of several novel mediators and mechanisms involved in regulating intracellular Ca2+ and contractility of cerebral arteries. Through their constrictor and dilator activity, cerebral arteries tightly regulate blood flow and capillary ..
  61. Role of Gap Junctions in EDHF-Mediated Dilations
    ELKE SOKOYA; Fiscal Year: 2007
    ..My laboratory has shown that EDHF-mediated dilations in middle cerebral arteries are attenuated in females compared to males, an effect attributed to estrogen...
  62. SRF/MYOCD: new targets in Alzheimer's neurovasculature
    JOSEPH MIANO; Fiscal Year: 2009
    ..following hypothesis: elevated SRF/MYOCD activity in AD VSMC leads to a hypercontractile phenotype in small cerebral arteries and the accumulation of A? which contribute to CBF reductions and neurovascular uncoupling as seen in A?, ..
  63. ELECTROPHYSIOLOGY OF CEREBRAL VASCULAR SMOOTH MUSCLE
    David Harder; Fiscal Year: 1980
    ..study is designed to elucidate some of the electrophysiological properties of smooth muscle cells from cerebral arteries. We will determine membrane electrical parameters such as; resistance, capacitance, resitivity and the ..
  64. Hemodynamic predictors of brain and cognitive aging
    Naftali Raz; Fiscal Year: 2005
    ..the links between age-related slowing of cerebral arterial blood velocity (CBF-V) in anterior and middle cerebral arteries, as a marker for cerebral hypoperfusion, and regional increase in white matter hyperintensities (WMH) burden ..
  65. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....