aorta

Summary

Summary: The main trunk of the systemic arteries.

Top Publications

  1. ncbi ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    Y Nakashima
    Department of Pathology, University of Washington, Seattle 98195
    Arterioscler Thromb 14:133-40. 1994
  2. pmc Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    Jennifer P Habashi
    Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 312:117-21. 2006
  3. ncbi Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 37:1236-41. 2001
  4. pmc Arterial stiffness and cardiovascular events: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    Circulation 121:505-11. 2010
  5. ncbi Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    L Gu
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 2:275-81. 1998
  6. ncbi Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population
    Tine Willum-Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    Circulation 113:664-70. 2006
  7. pmc Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    Elena Galkina
    Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 203:1273-82. 2006
  8. ncbi Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study
    Francesco U S Mattace-Raso
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Circulation 113:657-63. 2006
  9. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
  10. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001

Research Grants

  1. Sharon M Moe; Fiscal Year: 2014
  2. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
  3. Iris Z Jaffe; Fiscal Year: 2016
  4. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
  5. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
  6. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
  7. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
  8. Imaging of Aortic Atherosclerosis and Inflammation in the Metabolic Syndrome
    Warren J Manning; Fiscal Year: 2012
  9. AMPK Endothelial Cell Dysfunction and the Metabolic Syndrome (PROGRAM PROJECT)
    Neil B Ruderman; Fiscal Year: 2013
  10. KATHLEEN RAMAN; Fiscal Year: 2016

Detail Information

Publications380 found, 100 shown here

  1. ncbi ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    Y Nakashima
    Department of Pathology, University of Washington, Seattle 98195
    Arterioscler Thromb 14:133-40. 1994
    ..of lesions in the aortic root, at the lesser curvature of the aortic arch, the principal branches of the aorta, and in the pulmonary and carotid arteries...
  2. pmc Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    Jennifer P Habashi
    Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 312:117-21. 2006
    ....
  3. ncbi Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 37:1236-41. 2001
    ..This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension...
  4. pmc Arterial stiffness and cardiovascular events: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    Circulation 121:505-11. 2010
    ..Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffness measures to prognosis in the community...
  5. ncbi Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    L Gu
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 2:275-81. 1998
    ..Thus, MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder...
  6. ncbi Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population
    Tine Willum-Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    Circulation 113:664-70. 2006
    ..Few population studies addressed the prognostic significance of aortic pulse wave velocity (APWV) above and beyond other cardiovascular risk factors...
  7. pmc Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    Elena Galkina
    Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 203:1273-82. 2006
    ..Adoptively transferred lymphocytes constitutively homed to the aorta and resided within the adventitia up to 7 d after transfer...
  8. ncbi Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study
    Francesco U S Mattace-Raso
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Circulation 113:657-63. 2006
    ..We evaluated whether arterial stiffness is a predictor of coronary heart disease and stroke in a population-based study among apparently healthy subjects...
  9. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
    ..The full text of this article is available at http://www.circresaha.org...
  10. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
    ..The area of early atherosclerotic lesions in the aorta, quantified by en face oil red O staining, was reduced significantly in Vcam1(D4D/D4D) mice, although cholesterol ..
  11. ncbi Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers
    S A Steitz
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Circ Res 89:1147-54. 2001
    ..The findings suggest a positive role for SMCs in promoting vascular calcification...
  12. pmc Vitamin D receptor activators can protect against vascular calcification
    Suresh Mathew
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 19:1509-19. 2008
    ..At protective dosages, the VDR activators reduced osteoblastic gene expression in the aorta, which is normally increased in CKD, perhaps explaining this inhibition of aortic calcification...
  13. pmc The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease
    L Elia
    Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0613C, USA
    Cell Death Differ 16:1590-8. 2009
    ..Loss of miR-143 and miR-145 expression induces structural modifications of the aorta, because of an incomplete differentiation of VSMCs...
  14. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
    ..This study provides the first direct evidence in a longitudinal study that aortic stiffness is an independent predictor of primary coronary events in patients with essential hypertension...
  15. pmc Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice
    Debra L Rateri
    Saha Cardiovascular Research Center, BBSRB, Room 243, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 108:574-81. 2011
    ..for angiotensin II (Ang II)-based mechanisms as an underlying cause of aneurysms localized to the ascending aorta. In agreement with this associative evidence, we have published recently that Ang II infusion induces aneurysmal ..
  16. doi Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery
    Veronica Jackson
    Cardiothoracic Surgery Unit at the Department of Molecular Medicine and Surgery at Karolinska Institutet and Karolinska University Hospital
    Eur J Cardiothorac Surg 40:e118-24. 2011
    ..weakness of the aortic wall? This study evaluated the possibility of BAV morphology being related to ascending aorta morphology as such a correlation would strengthen the idea that hemodynamic alterations cause the dilatation of ..
  17. ncbi Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    Nature 394:894-7. 1998
    ..These data reveal a role for MCP-1 in the development of early atherosclerotic lesions and suggest that upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation...
  18. pmc Angiotensin II blockade and aortic-root dilation in Marfan's syndrome
    Benjamin S Brooke
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    N Engl J Med 358:2787-95. 2008
    ..We evaluated the clinical response to ARBs in pediatric patients with Marfan's syndrome who had severe aortic-root enlargement...
  19. doi Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells
    Jan H N Lindeman
    Department of Vascular Surgery, K6R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 119:2209-16. 2009
    ..We thus hypothesized that doxycycline acts through an effect on vascular inflammation...
  20. ncbi The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues
    Maria G Minasi
    Stem Cell Research Institute, DIBIT, H S Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Development 129:2773-83. 2002
    We have previously reported the origin of a class of skeletal myogenic cells from explants of dorsal aorta. This finding disagrees with the known origin of all skeletal muscle from somites and has therefore led us to investigate the in ..
  21. pmc Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    Sean B Joseph
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1662, USA
    Proc Natl Acad Sci U S A 99:7604-9. 2002
    ..These observations provide direct evidence for an atheroprotective effect of LXR agonists and support their further evaluation as potential modulators of human cardiovascular disease...
  22. ncbi Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice
    Niels R Veillard
    Division Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
    Circ Res 94:253-61. 2004
    ..Thus, our findings indicate that blockade of chemokine receptor/ligand interactions might become a novel therapeutic strategy to reduce the evolution of this common disease...
  23. ncbi Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hypertension 50:197-203. 2007
    ..These findings support prospective examination of use of central blood pressure as a treatment target in future trials...
  24. pmc Flow measurement by cardiovascular magnetic resonance: a multi-centre multi-vendor study of background phase offset errors that can compromise the accuracy of derived regurgitant or shunt flow measurements
    Peter D Gatehouse
    CMR Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 12:5. 2010
    ..We studied the severity of uncorrected velocity offset errors across sites and CMR systems...
  25. doi Influence of bicuspid valve geometry on ascending aortic fluid dynamics: a parametric study
    Christian Vergara
    Department of Information Engineering and Mathematical Methods, University of Bergamo, Italy
    Artif Organs 36:368-78. 2012
    ..a complementary, hemodynamic hypothesis stating that it is the peculiar fluid dynamics of blood in the ascending aorta of patients with BAV configurations that leads to aneurysm formation...
  26. ncbi Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy
    Michael F O'Rourke
    St Vincent s Clinic, University of New South Wales, VCCRI, Sydney, Australia
    Hypertension 46:200-4. 2005
    ..The logical approach to prevention and treatment requires reduction of central pulse pressure. Because the aorta and large arteries are not directly affected by drugs, this entails reduction of wave reflection by dilation of ..
  27. pmc Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism
    Jennifer P Habashi
    Howard Hughes Medical Institute and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 332:361-5. 2011
    ..We show that loss of AT2 expression accelerates the aberrant growth and rupture of the aorta in a mouse model of Marfan syndrome (MFS)...
  28. ncbi Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Circulation 111:3384-90. 2005
    Aging results in vascular stiffening and an increase in the velocity of the pressure wave as it travels down the aorta. Increased aortic pulse wave velocity (aPWV) has been associated with mortality in clinical but not general ..
  29. ncbi Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
    T North
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Development 126:2563-75. 1999
    ..Cbfa2 are in the yolk sac, the vitelline and umbilical arteries, and in the ventral aspect of the dorsal aorta in the aorta/genital ridge/mesonephros (AGM) region...
  30. pmc Hematopoietic stem cell fate is established by the Notch-Runx pathway
    Caroline Erter Burns
    Stem Cell Program and Division of Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2331-42. 2005
    ..during embryogenesis via an inducible transgenic system led to a Runx1-dependent expansion of HSCs in the aorta-gonad-mesonephros (AGM) region...
  31. ncbi Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    Jian Xu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 116:944-53. 2007
    ....
  32. ncbi Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice
    Kiran Saraff
    Division of Cardiovascular Medicine, Gill Heart Institute, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 23:1621-6. 2003
    ....
  33. ncbi Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3
    Guangdong Yang
    Department of Physiology, College of Medicine, Cardiovascular Research Group, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    FASEB J 18:1782-4. 2004
    ..In this study, we demonstrate that H2S at physiologically relevant concentrations induced apoptosis of human aorta smooth muscle cells (HASMCs)...
  34. ncbi Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 100:2473-6. 1999
    ..The present study investigated whether adiponectin could modulate endothelial function and relate to coronary disease...
  35. ncbi Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD
    Joanne L Reynolds
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Soc Nephrol 15:2857-67. 2004
    ..These vesicles contain mineralization inhibitors derived from VSMC and serum, and perturbation of the production or function of these inhibitors would lead to accelerated vascular calcification...
  36. doi Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review
    Marina Cecelja
    King s College London British Heart Foundation Centre, Cardiovascular Division, Department of Clinical Pharmacology, St Thomas Hospital, London, United Kingdom
    Hypertension 54:1328-36. 2009
    ..The prognostic value of cfPWV may relate to a process of arterial ageing unrelated to classic risk factors other than hypertension...
  37. ncbi Usefulness of bicuspid aortic valve phenotype to predict elastic properties of the ascending aorta
    Benjamin M Schaefer
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 99:686-90. 2007
    ..Aortic dimensions were measured at the sinuses of Valsalva, ascending aorta, and aortic arch. Distensibility and stiffness index were calculated using cuff blood pressure. Mean age was 41...
  38. pmc Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice
    Alan Daugherty
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, U S A
    Clin Sci (Lond) 118:681-9. 2010
    ..All regions of the ascending aorta of AngII-infused mice had diffuse medial macrophage accumulation...
  39. pmc Proteomics characterization of extracellular space components in the human aorta
    Athanasios Didangelos
    King s British Heart Foundation Centre, King s College, London, United Kingdom
    Mol Cell Proteomics 9:2048-62. 2010
    ....
  40. doi Arterial stiffness, physical function, and functional limitation: the Whitehall II Study
    Eric J Brunner
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK
    Hypertension 57:1003-9. 2011
    ..The nature of the link between arterial stiffness and quality of life in older people merits attention...
  41. ncbi Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells
    Jaw Wen Chen
    National Yang Ming University School of Medicine, Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China
    Arterioscler Thromb Vasc Biol 23:1559-66. 2003
    ....
  42. ncbi Central blood pressure measurements and antihypertensive therapy: a consensus document
    Enrico Agabiti-Rosei
    Clinica Medica and Department of Medicine, University Hospital, Brescia, Italy
    Hypertension 50:154-60. 2007
  43. doi Validation and reproducibility of aortic pulse wave velocity as assessed with velocity-encoded MRI
    Heynric B Grotenhuis
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Magn Reson Imaging 30:521-6. 2009
    ..To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV(MRI)) with PWV determined from invasive intra-aortic pressure measurements (PWV(INV)) and to test the reproducibility of the measurement by MRI...
  44. pmc Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels
    Asif K Mustafa
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 109:1259-68. 2011
    ..Hydrogen sulfide (H(2)S) is a prominent EDRF, since mice lacking its biosynthetic enzyme, cystathionine γ-lyase (CSE), display pronounced hypertension with deficient vasorelaxant responses to acetylcholine...
  45. ncbi Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice
    R K Tangirala
    Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Lipid Res 36:2320-8. 1995
    ..origin, where particular pathogenic conditions may exist, correlates with lesion formation throughout the entire aorta, we measured the extent of atherosclerosis in both areas in 8 apoE- and 11 LDL receptor-deficient mice fed ..
  46. pmc Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    J Appl Physiol (1985) 105:1652-60. 2008
    ....
  47. ncbi Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products
    Biao Xu
    Center for Cardiovascular Biology and Medicine, King s College London, London SE1 1UL, UK
    FASEB J 17:1289-91. 2003
    ..In isolated rabbit aorta, this effect was reversible after AGE-Glu washout, and the response to the endothelium-independent vasodilator ..
  48. ncbi A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization
    M Eto
    Division of Chemistry, Hokkaido University
    J Biochem 118:1104-7. 1995
    A novel phosphorylation-dependent inhibitory protein (IP) of porcine aorta myosin light chain phosphatase (PA-MLCP) was purified to homogeneity from porcine aorta media. The molecular mass of IP was 20 kDa...
  49. pmc Endothelial protein kinase C isoform identity and differential activity of PKCzeta in an athero-susceptible region of porcine aorta
    Richard Magid
    Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6383, USA
    Circ Res 97:443-9. 2005
    Endothelial protein kinase C (PKC) signaling was investigated in different regions of normal porcine aorta. The locations map to differential atherosclerotic susceptibility and correlate with sites of disturbed (DF) or undisturbed (UF) ..
  50. ncbi Salvianolic acid B attenuates cyclooxygenase-2 expression in vitro in LPS-treated human aortic smooth muscle cells and in vivo in the apolipoprotein-E-deficient mouse aorta
    Yuh Lien Chen
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Biochem 98:618-31. 2006
    ..This new mechanism of action of Sal B, in addition to its previously reported inhibition of LDL oxidation, may help explain its efficacy in the treatment of atherosclerosis...
  51. ncbi Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?
    Kennedy Cruickshank
    Clinical Epidemiology Group, School of Epidemiology and Health Sciences, University of Manchester Medical School, Manchester, UK
    Circulation 106:2085-90. 2002
    ..We tested whether aortic PWV predicts cardiovascular and all-cause mortality in type 2 diabetes and glucose-tolerance-tested (GTT) multiethnic population samples...
  52. ncbi Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta
    Liming Jin
    Dept of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3000, USA
    Am J Physiol Heart Circ Physiol 287:H1495-500. 2004
    ..These observations demonstrate that ROS-induced Ca(2+) sensitization is through activation of Rho and a subsequent increase in Rho kinase activity but not Ca(2+)-independent PKC...
  53. pmc Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis
    Jenny Jongstra-Bilen
    Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 203:2073-83. 2006
    ..In the intima of atherosclerosis-predisposed regions of the wild-type C57BL/6 mouse aorta, we quantified increased expression of several proinflammatory genes that have been implicated in atherogenesis, ..
  54. pmc Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1
    Alex Robert-Moreno
    Centre Oncologia Molecular, IDIBELL, Gran Via km 2 7 Hospitalet, Barcelona, Spain
    EMBO J 27:1886-95. 2008
    ..for the correct execution of the definitive haematopoietic programme, including expression of GATA2 in the dorsal aorta. Moreover, successful haematopoietic rescue of the Jagged1-null AGM cells was obtained by culturing them with ..
  55. doi The molecular basis of vascular lumen formation in the developing mouse aorta
    Boris Strilic
    Institute of Metabolic Physiology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
    Dev Cell 17:505-15. 2009
    ..Here, we investigated vascular lumen formation in the developing aorta, the first and largest arterial blood vessel in all vertebrates...
  56. pmc MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function
    Sebastian Albinsson
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 30:1118-26. 2010
    ..Here, we investigated the role of miRNAs in VSM by deleting the rate-limiting enzyme in miRNA synthesis, Dicer...
  57. ncbi Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?
    Michael A Borger
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Thorac Cardiovasc Surg 128:677-83. 2004
    The optimal diameter at which replacement of the ascending aorta should be performed in patients with bicuspid aortic valve disease is not known.
  58. doi Aortic stiffness is independently associated with rate of renal function decline in chronic kidney disease stages 3 and 4
    Martin L Ford
    Brighton and Sussex Medical School, University of Sussex, Brighton, East Sussex, United Kingdom
    Hypertension 55:1110-5. 2010
    ..17; P=0.039), and urine protein:creatinine ratio (r=0.20; P=0.021). We, therefore, conclude that aortic stiffening is independently associated with rate of change in renal function in patients with chronic kidney disease stages 3 and 4...
  59. ncbi LRP: role in vascular wall integrity and protection from atherosclerosis
    Philippe Boucher
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Science 300:329-32. 2003
    ..Thus, LRP1 has a pivotal role in protecting vascular wall integrity and preventing atherosclerosis by controlling PDGFR activation...
  60. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    ..At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and coronary and pulmonary arteries...
  61. ncbi A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter
    C S Ng
    Department of Radiology, Royal Brompton National Heart and Lung Hospital, London, England
    J Thorac Imaging 14:270-8. 1999
    ..this study was to determine whether the ratio of the diameters of the main pulmonary artery and of the ascending aorta (rPA), as assessed on computed tomography (CT), is predictive of pulmonary arterial hypertension (PAH)...
  62. pmc Detection of Treponema denticola in atherosclerotic lesions
    K Okuda
    Oral Health Science Center, Tokyo Dental College, 1 2 2, Masago, Mihama ku, Chiba, Japan
    J Clin Microbiol 39:1114-7. 2001
    We examined 26 atherosclerotic lesions and 14 nondiseased aorta specimens to detect the periodontopathogenic part of the bacterial 16S rRNA locus by PCR...
  63. ncbi Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging
    Edward G Lakatta
    Gerontology Research Center, Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Circulation 107:490-7. 2003
  64. doi Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area
    Arik Wolak
    Departments of Imaging, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California at Los Angeles, USA
    JACC Cardiovasc Imaging 1:200-9. 2008
    To determine normal limits for ascending and descending thoracic aorta diameters in a large population of asymptomatic, low-risk adult subjects.
  65. pmc Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling
    Katharina Lotzer
    Institute for Vascular Medicine, Friedrich Schiller University of Jena, Bachstrasse 18, 07743 Jena, Germany
    Arterioscler Thromb Vasc Biol 30:395-402. 2010
    Mouse aorta smooth muscle cells (SMC) express tumor necrosis factor receptor superfamily member 1A (TNFR-1) and lymphotoxin beta-receptor (LTbetaR)...
  66. pmc Haematopoietic stem cells derive directly from aortic endothelium during development
    Julien Y Bertrand
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0380, USA
    Nature 464:108-11. 2010
    ..waves during zebrafish development, with HSCs arising in the final wave in close association with the dorsal aorta. Recent reports have suggested that murine HSCs derive from haemogenic endothelial cells (ECs) lining the aortic ..
  67. doi Mechanistic insight into the physiological relevance of helical blood flow in the human aorta: an in vivo study
    Umberto Morbiducci
    Department of Mechanics, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129, Turin, Italy
    Biomech Model Mechanobiol 10:339-55. 2011
    The hemodynamics within the aorta of five healthy humans were investigated to gain insight into the complex helical flow patterns that arise from the existence of asymmetries in the aortic region...
  68. doi Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice
    Wing Tak Wong
    Institute of Vascular Medicine, Chinese University of Hong Kong, Hong Kong, China Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Cell Metab 14:104-15. 2011
    ..Thus, the adipose tissue represents a promising target for treating diabetic vasculopathy...
  69. doi The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification
    Daisuke Saito
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Science 336:1578-81. 2012
    ..We found that the dorsal aorta acts as a morphogenetic signaling center that coordinates NCC migration and cell lineage segregation...
  70. doi Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide
    Ling Li
    Department of Pharmacology, National University of Singapore, Singapore
    Circulation 117:2351-60. 2008
    ....
  71. doi Invasive validation of a new oscillometric device (Arteriograph) for measuring augmentation index, central blood pressure and aortic pulse wave velocity
    Ivan G Horvath
    aHeart Institute, Medical School, University of Pecs, Pecs, Hungary bDepartment of Cardiology, University of Rome La Sapienza, Polo Pontino, Italy
    J Hypertens 28:2068-75. 2010
    ..The aim of this study was to evaluate the accuracy of a new, easily applicable oscillometric device (Arteriograph), determining these parameters simultaneously, against invasive measurements...
  72. ncbi Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products
    Qian Cai
    Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi Lu Hospital of Shandong University, China
    Biosci Biotechnol Biochem 75:1692-7. 2011
    ..GSPB2 may therefore have therapeutic potential in preventing and treating vascular complications of diabetes mellitus...
  73. doi Use of the mouse aortic ring assay to study angiogenesis
    Marianne Baker
    Adhesion and Angiogenesis Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK
    Nat Protoc 7:89-104. 2011
    ..The assay takes 6-14 d to complete, depending on the age of the mice, treatments applied and whether immunostaining is performed...
  74. pmc Mechanical stretch modulates microRNA 21 expression, participating in proliferation and apoptosis in cultured human aortic smooth muscle cells
    Jian Tao Song
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    PLoS ONE 7:e47657. 2012
    ..We tested whether the expression of microRNA 21 (miR-21) is modulated by stretch and is involved in stretch-induced proliferation and apoptosis of human aortic smooth muscle cells (HASMCs)...
  75. pmc Biomechanical forces promote embryonic haematopoiesis
    Luigi Adamo
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 459:1131-5. 2009
    ..After initiation of the heartbeat in vertebrates, cells lining the ventral aspect of the dorsal aorta, the placental vessels, and the umbilical and vitelline arteries initiate expression of the transcription factor ..
  76. pmc Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3
    A Phillip Owens
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 106:611-9. 2010
    ..Angiotensin II (Ang II) has diverse effects on smooth muscle cells (SMCs). The diversity of effects may relate to the regional location of this cell type...
  77. doi Prevalence of Chlamydophila pneumoniae is higher in aorta and coronary artery than in carotid artery of coronary artery disease patients
    Hem C Jha
    Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India
    APMIS 117:905-11. 2009
    ..pneumoniae, H. pylori, CMV and HSV-1 in different vascular locations were as follows: aorta (64.7, 35.3, 11.7 and 11.7 respectively); carotid (27.2, 27.2, 9 and 0 respectively); coronary artery (58.3, 33...
  78. doi Endothelial function, carotid-femoral stiffness, and plasma matrix metalloproteinase-2 in men with bicuspid aortic valve and dilated aorta
    Nikolaos Tzemos
    Division of Cardiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 55:660-8. 2010
    ..This study sought to examine the relationship between proximal aortic dilation and systemic vascular function in men with bicuspid aortic valve (BAV)...
  79. ncbi MG132, a proteasome inhibitor, attenuates pressure-overload-induced cardiac hypertrophy in rats by modulation of mitogen-activated protein kinase signals
    Baolin Chen
    Department of Cardiology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Acta Biochim Biophys Sin (Shanghai) 42:253-8. 2010
    ..In conclusion, our results suggested that long-term treatment with MG132 attenuates pressureoverload-induced cardiac hypertrophy and improves cardiac function in AAB rats through regulation of ERK1/2 and JNK1 signaling pathways...
  80. pmc Angiotensin II mediates the high-glucose-induced endothelial-to-mesenchymal transition in human aortic endothelial cells
    Rining Tang
    Institute of Nephrology, Zhong Da Hospital, Southeast University, Nanjing 210009, China
    Cardiovasc Diabetol 9:31. 2010
    ..The aim of this study was to investigate the influence of HG on the endothelial-to-mesenchymal transition (EndMT) and its relevance to the activation of the renin-angiotensin system...
  81. pmc Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}
    Venkateswaran Subramanian
    Saha Cardiovascular Research Center, BBSRB, Room B243, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 107:953-8. 2010
    ..Peroxisome proliferator-activated receptor (PPAR)γ agonists attenuate atherosclerosis and abdominal aortic aneurysms (AAAs). PPARγ, a nuclear receptor, is expressed on many cell types including smooth muscle cells (SMCs)...
  82. pmc Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease
    Changcheng Zhou
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY, USA
    J Lipid Res 52:1483-93. 2011
    ..Thus, the Ins2(Akita)Ldlr⁻/⁻ mouse appears to be a promising model for mechanistic studies of type 1 diabetes-accelerated atherosclerosis...
  83. doi Ethnic differences in aortic pulse wave velocity occur in the descending aorta and may be related to vitamin D
    Mohammad Reza Rezai
    Diabetes, Nutrition and Cardiovascular Medicine Research Group, Franklin Wilkins Building level 4, King s College University of London and King s Health Partners, 150 Stamford Street, London SE1 9NH, UK
    Hypertension 58:247-53. 2011
    ..PWVs over the aortic arch and descending aorta were measured by magnetic resonance in a subsample (n=47)...
  84. doi Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent
    Ji Seok Baik
    Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Korea
    Can J Physiol Pharmacol 89:467-76. 2011
    ..were to investigate the calcium-dependent mechanism underlying levobupivacaine-induced contraction of isolated rat aorta in vitro and to elucidate the pathway responsible for the endothelium-dependent attenuation of levobupivacaine-..
  85. doi Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension
    Yuan Chieh Lee
    Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Circulation 124:1160-71. 2011
    ..Its chemical nature remains unknown. We determined whether palmitic acid methyl ester (PAME) was the PVATRF and whether its release and/or vasorelaxing activity decreased in hypertension...
  86. pmc Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis
    Hong Lu
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Br J Pharmacol 165:2000-8. 2012
    ..The purpose of this study was to determine the relative effects of these three modes of pharmacological RAS inhibition in reducing atherosclerosis by determining the dose-response relationships...
  87. doi Relationship between magnesium and clinical biomarkers on inhibition of vascular calcification
    Silvia Salem
    Charite, Medical Clinic IV, University of Berlin, Germany
    Am J Nephrol 35:31-9. 2012
    ..Furthermore, plasma Mg(2+) concentrations of ESRD and healthy controls were investigated for association with surrogate parameters of vascular calcification in vivo...
  88. ncbi Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny
    T Jaffredo
    Institut d Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France 49 bis, avenue de la Belle Gabrielle, France
    Development 125:4575-83. 1998
    ..the developmental relationship of the hemopoietic and endothelial lineages in the floor of the chicken aorta, a site of hemopoietic progenitor emergence in the embryo proper...
  89. ncbi Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure
    A P Guerin
    , , , , , Paris, France
    Circulation 103:987-92. 2001
    ....
  90. doi Cinacalcet suppresses calcification of the aorta and heart in uremic rats
    Takehisa Kawata
    Pharmacology Group, Development Research Laboratories, Research Division, Kirin Pharma Co, Ltd, Takasaki, Japan
    Kidney Int 74:1270-7. 2008
    ..Here we measured the effects of oral cinacalcet on calcification of the aorta and heart in rats with a remnant kidney (5/6 nephrectomy) model of uremia that were fed a high-phosphate diet ..
  91. doi c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative stress
    Elena Osto
    Cardiology and Cardiovascular Research, Institute of Physiology, Zurich, Switzerland
    Circulation 118:2073-80. 2008
    ..We investigated whether JNK2 deletion protects from hypercholesterolemia-induced endothelial dysfunction and oxidative stress...
  92. pmc Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans
    Alban Redheuil
    Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Hypertension 55:319-26. 2010
    ..In particular, compared with other measures of aortic function, the best markers of subclinical large artery stiffening, were AA distensibility in younger and aortic arch pulse wave velocity in older individuals...
  93. pmc Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos
    Tomomasa Yokomizo
    Erasmus MC Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
    Development 137:3651-61. 2010
    Hematopoietic cell clusters in the aorta of vertebrate embryos play a pivotal role in the formation of the adult blood system...
  94. doi Improved aortic pulse wave velocity assessment from multislice two-directional in-plane velocity-encoded magnetic resonance imaging
    Jos J M Westenberg
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Magn Reson Imaging 32:1086-94. 2010
    ..To evaluate the accuracy and reproducibility of aortic pulse wave velocity (PWV) assessment by in-plane velocity-encoded magnetic resonance imaging (MRI)...
  95. pmc Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
    Thiago M C Pereira
    Laboratory of Transgenes and Cardiovascular Control, Physiological Sciences Graduate Program, Health Sciences Center, Federal University of EspÃrito Santo, Av Marechal Campos 1468, Vitoria, ES 29043 900, Brazil
    Lipids Health Dis 9:87. 2010
    ..Our hypothesis was that advanced age-related cardiovascular changes are aggravated in atherosclerotic male mice...
  96. doi Subendocardial viability ratio estimated by arterial tonometry: a critical evaluation in elderly hypertensive patients with increased aortic stiffness
    Denis Chemla
    Paris Sud University, Research Team EA4046, Le Kremlin Bicetre, France
    Clin Exp Pharmacol Physiol 35:909-15. 2008
    ..4. The tonometric SEVR was not impaired in elderly hypertensive patients with increased aortic stiffness. In resting elderly and middle-aged individuals, the tonometric SEVR was mainly related to DT/ST ratio, not to aortic pressure...
  97. doi Caveolin-1 regulates BMPRII localization and signaling in vascular smooth muscle cells
    Jeffrey W Wertz
    Department of Surgery, University of Pittsburgh, BST 3, Room 6058, Pittsburgh, PA 15261, USA
    Biochem Biophys Res Commun 375:557-61. 2008
    ..Taken together, our findings establish caveolin-1 as an important regulator of downstream signaling and membrane targeting of BMPRII in vascular smooth muscle cells...
  98. doi Accelerated phase-contrast MR imaging: comparison of k-t BLAST with SENSE and Doppler ultrasound for velocity and flow measurements in the aorta
    Andreas Stadlbauer
    MR Physics Group, Department of Radiology, Landesklinikum St Poelten, Austria
    J Magn Reson Imaging 29:817-24. 2009
    To evaluate differences in velocity and flow measurements in the aorta between accelerated phase-contrast (PC) magnetic resonance imaging (MRI) using SENSE and k-t BLAST and in peak velocity to Doppler ultrasound.
  99. doi Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms
    Christiane Pilop
    Departments of Nephrology and Hypertension, University Hospital of Bern, Bern, Switzerland
    Circulation 120:983-91. 2009
    ..The most life-threatening manifestations are aortic aneurysm and dissection. We investigated changes in the proteome of aortic media in patients with and without MFS to gain insight into molecular mechanisms leading to aortic dilatation...
  100. doi Visceral arterial compromise during intra-aortic balloon counterpulsation therapy
    Ardawan Julian Rastan
    University of Leipzig, Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
    Circulation 122:S92-9. 2010
    ....
  101. pmc Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques
    C M Giachelli
    Department of Pathology SJ 60 University of Washington School of Medicine, Seattle 98195
    J Clin Invest 92:1686-96. 1993
    ..Injury to either the adult rat aorta or carotid artery using a balloon catheter initiated a qualitatively similar time-dependent increase in both ..

Research Grants84

  1. Sharon M Moe; Fiscal Year: 2014
    ..serum measures of mineral homeostasis, bone turnover, architecture and biomechanics, and arterial calcification, aorta compliance and left ventricular mass index...
  2. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..The first HSCs arise in the embryo from an area encompassing the dorsal aorta, termed the aorta-gonad mesonephros (AGM) region...
  3. Iris Z Jaffe; Fiscal Year: 2016
    ..We now have preliminary data demonstrating that direct activation of MR in the aorta induces expression of the pro-atherosclerotic gene, placental growth factor (PlGF), and that genetic deficiency of ..
  4. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..It has become increasingly apparent that the capacitance function of larger vessels, and in particular the aorta, modulates hemodynamics by accommodating a portion of stroke volume during systole, reducing systolic pressure and ..
  5. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..In hypertension and heart failure, Ac-SDKP prevents monocyte/macrophage infiltration and fibrosis in the aorta, kidneys and left ventricle (LV)...
  6. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..Aortic dissection describes a tear in the wall of the main vessel in the body, the aorta. The underlying pathology is diverse and predisposing factors include aortic aneurysms and diseases of the ..
  7. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
    ..It is also recognized that increased aorta stiffness, which exposes resistance vessels of the microvasculature to pulsatile flow, results in microvascular ..
  8. Imaging of Aortic Atherosclerosis and Inflammation in the Metabolic Syndrome
    Warren J Manning; Fiscal Year: 2012
    ..primarily affects large and medium sized vessels with autopsy data demonstrating that the abdominal aorta offers a valuable early window for the study of atherosclerosis...
  9. AMPK Endothelial Cell Dysfunction and the Metabolic Syndrome (PROGRAM PROJECT)
    Neil B Ruderman; Fiscal Year: 2013
    ..then assess the effect of these deletions on muscle capillarity (Projects 3 and 1) and atherogenic changes in the aorta (Project 2) in control mice and mice fed a high-fat/high sucrose diet...
  10. KATHLEEN RAMAN; Fiscal Year: 2016
    ..presence of RAGE on bone marrow derived leukocytes is sufficient to polarize macrophages into an M1 subtype in the aorta of elastase-perfused mice...
  11. STRUCTURE AND FUNCTION OF HEPARIN COFACTOR II
    Douglas M Tollefsen; Fiscal Year: 2010
    ..HC-/- mice also develop more atherosclerotic lesions in the aorta when hypercholesterolemic...
  12. IVAN B YANACHKOV; Fiscal Year: 2015
    ..human P2Y2, P2Y4, P2Y6, or P2X1 receptors, and had good safety margin in the endothelium P2Y-dependent guinea pig aorta relaxation model...
  13. ALBERT PHILLIP OWENS III; Fiscal Year: 2014
    ..dilation in the arterial wall with a diameter greater than 50% of normal, is an inflammatory disease of the aorta that can result in dissection of the wall, formation of an intramural clot, and rupture of th aorta resulting in ..
  14. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..biomarkers in retinal vasculature in vivo, and to correlate expression levels with plaque severity in proximal aorta ex vivo in a mouse model of atherosclerosis...
  15. Oxymax System with Teadmill for Quantifying Exercise in Mice
    Neil B Ruderman; Fiscal Year: 2012
    ..on the SIRT1/LKB1/AMPK/eNOS signaling mechanism that it has recently identified in the endothelium of the mouse aorta and is presently studying in other tissues...
  16. HUA LINDA CAI; Fiscal Year: 2016
    ..Ultrasound monitoring of abdominal aorta diameter in the survived mice and immediate dissection of the suddenly died mice revealed expansive or rupturing ..
  17. Mechanisms of vascular-specific gene regulation by estrogen
    Gavin R Schnitzler; Fiscal Year: 2013
    ..and microarray studies have shown that E2 regulates very different sets of genes in mouse liver versus mouse aorta, and also that distinct sets of genes are regulated in mouse aorta over increasing times of E2 treatment...
  18. Abdominal Adipose Tissue Inflammation
    Peter S Tobias; Fiscal Year: 2013
    ..a distinct atherosclerosis pathology to understand the cause of the exacerbated lesions found in the abdominal aorta of hyperlipidemic mice challenged with a chronic, systemic proinflammatory stimulus...
  19. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013
    ..During vertebrate development, the site of hematopoieis moves from the yolk sac of the embryo to the embryo dorsal aorta to the fetal liver, then to the fetal spleen and finally to the bone marrow...
  20. Integrated MRI-Based Examination for Evaluation of Peripheral Arterial Disease
    Felix W Wehrli; Fiscal Year: 2010
    ..of time-resolved aortic blood flow in a single heart beat simultaneously in the ascending and descending aorta for quantifying pulse-wave velocity and compliance. 2...
  21. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..The blood then passes through the pump and is returned to the ascending aorta. The Apical Copulsation Device (ACD) proposed here affords a very effective ventricular decompression and ..
  22. Paul J Boor; Fiscal Year: 2014
    ..DAA is the sudden tearing, or splitting of the layers of the muscular wall of the thoracic aorta. In humans, DAA affects those in the teen years to early adulthood, resulting in occlusion of distal vessels, ..
  23. KESAVALU NAIDU LAKSHMYYA; Fiscal Year: 2015
    ..inflammatory disease and several periodontal bacterial genomic DNA were detected in atherosclerosis plaque from aorta, carotid, and coronary arteries in humans...
  24. MUKESH KUMAR JAIN; Fiscal Year: 2015
    ..homeostatic mechanisms secondary to genetic and/or environmental factors can lead to permanent dilatations termed aorta aneurysms (AA)...
  25. Human CYP1A1, diet and dioxin-induced hypertension
    Mary K Walker; Fiscal Year: 2012
    ..by which CYP1A1 mediates TCDD-induced vascular dysfunction, using CYP1A1 WT and hCYP1A mice, and studying the aorta and mesenteric vasoreactivity ? and ?-3 PUFAs...
  26. EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSURE
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..In the rabbit aorta and mouse mesenteric artery, endothelium-dependent relaxations to acetylcholine (ACh) are reduced, but not blocked,..
  27. Jay D Humphrey; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The ascending aorta experiences unique multiaxial loading during each cardiac cycle: finite distension due to changes in blood pressure plus finite extension, torsion, and bending due to the direct ..
  28. Adiponetin and AMPK Biosensor
    John Y J Shyy; Fiscal Year: 2010
    ..The AMPK activity in the mouse aorta and the consequent vascular tone (i.e...
  29. Shiyou Chen; Fiscal Year: 2014
    ..SMC phenotype will be determined by morphological, biochemical and contractility assay in huMSC and rat aorta SMC...
  30. Transglutaminase 2 S-Nitrosylation: Role in Age-Related Vascular Stiffness
    Dan E Berkowitz; Fiscal Year: 2013
    ..We further demonstrate that in aging rat and human aorta, TG2 activity is increased, and it's S-nitrosylation is decreased despite unchanged TG2 abundance...
  31. Functional study of novel transcriptional regulators of hematopoietic stem cells
    Shannon L McKinney-Freeman; Fiscal Year: 2012
    ..The RNA- binding protein, Zfp36l1, was predicted by our analyses to regulate HSC specification in the aorta-gonads- mesonephros (AGM)...
  32. WILLIAM ANTHONY BAUMGARTNER; Fiscal Year: 2016
    ..circulatory arrest (HCA) is an established neuroprotective strategy allowing complex repairs of the thoracic aorta and congenital cardiac malformations...
  33. Implications of Endothelial-Myocyte Uncoupling in Cardiac Arrhythmia
    Suresh C Tyagi; Fiscal Year: 2010
    ..In these mice, chronic volume overload heart failure will be created by aorta-venacava (AV) fistula. NMDA-R1 will be blocked by dizocilpine (MK-801)...
  34. Gadiparthi N Rao; Fiscal Year: 2016
    ..15- LOX1/2 product of AA, 15(S)-HETE, via its capacity to trigger the migration and adhesion of macrophages to the aorta/artery under the influence of cardiovascular risk factors may set the soil for the development of atherosclerosis...
  35. Jeffrey A Jones; Fiscal Year: 2016
    ..devastating disease process which often lacks specific symptomology, rendering them unnoticed until the aorta ruptures, resulting in significant morbidity and mortality...
  36. Sadashiva S Karnik; Fiscal Year: 2015
    ..gene expression to hypertrophy and fibrosis, we profiled mRNA and microRNA (miRNA) expression in the AT1R TG mice aorta, heart, and in HL1-AT1R (cardiomyocyte) and the VSMC-AT1R cell lines...
  37. WILSON KENDRICK CLEMENTS; Fiscal Year: 2014
    ..in the formation or behavior of a somite compartment, the sclerotome, which is adjacent to the primitive dorsal aorta, the tissue that gives rise to the first HSCs in vertebrates...
  38. HAL C DIETZ; Fiscal Year: 2016
    ..to test the hypothesis that loss of matricellular integrin-ligand interaction is an inciting event in the MFS aorta and to test integrn-targeted therapies...
  39. Sharon M Moe; Fiscal Year: 2015
    ..We will determine if oral administration of cystamine, a broad TG inhibitor, can inhibit aorta vascular calcification in a naturally occurring rat model of CKD-MBD (Chronic Kidney Disease-Mineral Bone Disorder)..
  40. Hiromi Yanagisawa; Fiscal Year: 2014
    ..of Fbln4 and showed that lack of Fbln4 in SMCs (Fbln4SMKO) leads to aortic aneurysms exclusively in the ascending aorta by 3-months of age...
  41. Neural Crest Modulates FGF Signaling in the Pharynx
    Margaret Loewy Kirby; Fiscal Year: 2010
    ..is not added to the growing arterial pole and this results in conotruncal malalignment defects such as overriding aorta and double outlet right ventricle...
  42. Alpha Lipoic Acid Derivatives for Treatment of Hypertension
    DESIKAN RAJAGOPAL; Fiscal Year: 2010
    ..vascular inflammation, endothelial protection, ACE activity in heart and lung, super oxide generation in the aorta. In specific aim 3, we will further modify lead molecules derived from Aim 1 into "nitric oxide" releasing drugs ..
  43. Julie M Barkmeier-Kraemer; Fiscal Year: 2016
    ..increased aortic compliance, would impose increased stretch and compression to the RLN where it is adjacent to the aorta that can impair nerve function...
  44. Pax genes in cardiac development
    ZACHARY PAUL NEEB; Fiscal Year: 2012
    ..by Pax3 or the great arteries exiting the heart will not be appropriately remodeled to give rise to a separate aorta and pulmonary trunk...
  45. TNF-ALPHA AND BMP2-WNT SIGNALING IN DIABETIC VASCULAR DISEASE
    Dwight A Towler; Fiscal Year: 2012
    ..g., heart, aorta) &microvascular (e.g. retina, renal glomerulus) functions...
  46. Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
    Scott A LeMaire; Fiscal Year: 2011
    ..TAAD will occur in an aorta if one or more of the following conditions are present: 1) original aortic structure is too weak;2) destructive ..
  47. Hematopoietic Stem Cell Development in Zebrafish
    YARIV J HOUVRAS; Fiscal Year: 2010
    ..Recent experiments in our lab have defined the genesis of adult HSCs in the aorta-gonad-mesonephros (AGM) of the developing zebrafish...
  48. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2013
    ..We will instead use the rabbit renal circulation since it presents an arterial bifurcation (aorta to renal) of similar dimensions as the MCA...
  49. John S Ikonomidis; Fiscal Year: 2015
    ..that defects in TGF-b signaling are responsible for age-dependent changes in TAA progression in the "old" aorta. The outcomes from this project will establish that the structural and compositional changes in the aortic ECM of ..
  50. Regulation of Vascular Smooth Muscle Calcium by NADPH Redox
    Sachin A Gupte; Fiscal Year: 2012
    ..function after inhibiting G6PD with pharmacological agents and siRNA transfection, and in G6PD deficient mouse aorta. In Aim #3, we will determine whether glucose-6-phosphate dehydrogenase modulates the L-type Ca2+ channel function,..
  51. Role of mesenchymal stem cells in the blood stem cell niche
    Paul S Frenette; Fiscal Year: 2012
    ..In Specific Aim I, we will evaluate the spatial location and relationships of HSCs with Nestin+ cells in the aorta-gonad-mesonephros (AGM) region and the fetal liver...
  52. Zhiyong Lin; Fiscal Year: 2016
    ..Insights gleaned from clinical, pathologic, and experimental studies indicate that local inflammation of the aorta, fragmentation of the extracellular matrix, and loss of smooth muscle cells are central features in the initiation ..
  53. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    JACK CABELL GRIFFIS; Fiscal Year: 2012
    ..An abdominal aortic aneurysm (AAA) is a condition in which the aorta, the main blood vessel in the abdomen, expands like a balloon...
  54. Cellular Mechanisms of Vasoregulation by Volatile Anesthetics
    Rostislav Bychkov; Fiscal Year: 2012
    ..Specific Aim 1: To determine pharmacology of blockers-resistive K2P-like currents in thoracic aorta and middle cerebral artery...
  55. Angiotensin II, oxidative stress and aneurysm formation
    Neal L Weintraub; Fiscal Year: 2013
    ..aortic aneurysms are common in elderly Americans and can lead to progressive enlargement and even rupture of the aorta, the largest blood vessel in the body...
  56. Role of CYP P450s in the Regulation of Vascular Tone through Adenosine Receptors
    S Jamal Mustafa; Fiscal Year: 2013
    ..To test this hypothesis, we will use A2A AR-/-, A2A AR+/+, A1 AR-/- and A1 AR+/+ mice aorta employing organ bath;+/- endothelium;AR agonists &antagonists;CYP epoxygenases inhibitors;EETs &20-HETE ..
  57. Profilin-1 phosphorylation in neovascularization
    Yi Fan; Fiscal Year: 2013
    ..Deficiency in Pfn-1 phosphorylation inhibits EC sprouting in the aorta and wound-induced neovascularization, and also suppresses VSC homing to the ischemic hindlimb, suggesting a ..
  58. Mehran M Sadeghi; Fiscal Year: 2016
    ..Aneurysm will be induced in the mouse aorta through angiotensin II infusion...
  59. Mechanisms of abdominal aortic aneurysm formation
    Alan Daugherty; Fiscal Year: 2010
    ..II promotes aneurysm formation by initiating regional-specific matrix degradation in the media of the abdominal aorta, leading to recruitment of macrophages, medial dissection, and subsequent vascular remodeling...
  60. THOMAS GILLETTE GLEASON; Fiscal Year: 2016
    ..SMCs, disrupted matrix architecture and altered biomechanical tensile and delamination strengths in the ascending aorta of BAV patients compared with tricuspid aortic valve (TAV)-TAA and non- aneurysmal patients...
  61. The Role of LOX/LOXL Family Members in Abdominal Aortic Aneurysms (AAA)
    EBONY WASHINGTON; Fiscal Year: 2010
    ..AAA is a permanent dilation of the abdominal aorta that exceeds the normal aortic diameter by more than 50%...
  62. Suresh C Tyagi; Fiscal Year: 2016
    ..Chronic heart failure will be created by LV volume overload by aorta-venacava fistula (AVF) in wild type (WT), PAR-1-/+, iNOS-/-, MMP-9-/-, TIMP-3-/-, and TIMP-4++/++ mice, treated ..
  63. CEREBRAL FUNCTION AFTER HYPOTHERMIC CIRCULATORY ARREST
    Gabriele DiLuozzo; Fiscal Year: 2012
    ..find a way to provide flow to the visceral vessels either by devising a simple system for branched stents from the aorta, or by providing flow from the ascending aorta or iliac arteries (extra-anatomic debranching)...
  64. Development of Experimental and Computational Models for Traumatic Aortic Rupture
    Kurosh Darvish; Fiscal Year: 2009
    ..In Specific Aim 1 a physical model of TAR will be developed. This model will consist of a porcine aorta-heart specimen installed in a model of thorax made from clear silicone and urethane with similar compression ..
  65. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    Jack Griffis; Fiscal Year: 2009
    ..An abdominal aortic aneurysm (AAA) is a condition in which the aorta, the main blood vessel in the abdomen, expands like a balloon...
  66. Exchangeable Heart Valve for Tissue Engineering Applications
    Ivan Vesely; Fiscal Year: 2007
    ..is a two-component device, consisting of a permanent "docking station" that remains affixed to the patient's aorta, and a collapsible frame that supports the exchangeable leaflet set and plugs into the docking station...
  67. PATHOGENESIS OF DISEASE IN MUCOPOLYSACCHARIDOSIS I AND VII
    Katherine P Ponder; Fiscal Year: 2010
    ..that upregulation of proteases that degrade these proteins is a common pathophysiological pathway to disease in aorta and spine...
  68. INHIBITORY LEFT ATRIAL INFLUENCES ON THE BAROREFLEX
    David Ramsay; Fiscal Year: 1991
    ..constriction of cuffs placed around the thoracic portion of the inferior vena cava, pulmonary artery, ascending aorta and abdominal aorta proximal to the renal arteries...
  69. Bioengineering Studies of Abdominal Aortic Aneurysm Fluid and Wall Dynamics
    ENDER FINOL; Fiscal Year: 2009
    ..environment of the native AAAs will be reproduced by non-invasively evaluating blood flow in the abdominal aorta, aneurysmal wall thickness and wall motion as it is mediated by the cardiac cycle...
  70. Development of an Implantable "Plug and Play" TransApical to Aorta VAD
    Stephen Topaz; Fiscal Year: 2007
    ..All current LVADs used to treat post-cardiotomy shock use a blood return graft (or cannula) to the aorta and a large cannula (>16 mm outer diameter) through the cardiac apex...
  71. The human placenta as a novel source of hematopoietic stem cells
    Alicia Barcena; Fiscal Year: 2009
    ..Cells resembling primitive hematopoietic progenitors are first detected in the human aorta-gonad-mesonephros (AGM) region at day 27 and the population quickly expands until their disappearance by day 40...
  72. HDL AND PLAQUES--NOVEL MODELS AND IMAGING TECHNIQUES
    Edward Fisher; Fiscal Year: 2001
    ..3, magnetic resonance imaging (MRI), capable of noninvasively characterizing advanced lesions in mouse abdominal aorta, will be further developed to serially assess lesion changes in mice (from Projects 1 and 2) during plaque ..
  73. ARTERIAL BARORECEPTORS IN CARDIOVASCULAR CONTROL
    Robert Cox; Fiscal Year: 1980
    ..Measurement of pulsatile pressure and flow will be made in the ascending aorta, celiac, mesenteric, renal and iliac arteries...
  74. New roles of Src tyrosine kinases in vascular tone
    LIGIA TORO DE STEFANI; Fiscal Year: 2007
    ..of TXA2 and 5-HT2A receptors in smooth muscle cells from blood vessels subject to thrombotic episodes, like aorta, coronary, and cerebral arteries...
  75. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..application we propose to assess the utility of transplanting neonatal or fetal cardiac cells directly into the aorta of rodents. The concept is to build a biologic ventricular assist device or an auxiliary heart...
  76. BIOMECHANICAL EVALUATION OF ABDOMINAL AORTIC ANEURYSM
    DAVID ALAN VORP; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) is a focal enlargement of the infrarenal aorta. If left untreated, AAA will gradually expand until rupture, an event that carries a mortality rate of 90%...
  77. ATHEROSCLEROSIS & W-3 FATTY ACIDS IN ALASKAN NATIVES
    William Newman; Fiscal Year: 1993
    ..and the extent of atherosclerotic lesions (fatty streaks and raised lesions) in the coronary arteries and aorta in autopsied Alaskan natives (Aleuts, Indians, and Eskimos) and in non-natives dying of all causes, 2) to examine ..
  78. Quantifying altered hemodynamics in response to stenting for aortic coarctation
    JOHN LADISA; Fiscal Year: 2009
    Coarctation of the aorta (CoA) is a congenital heart disease characterized by a severe stenosis of the main artery that delivers blood from the heart to the rest of the body...