arteries

Summary

Summary: The vessels carrying blood away from the heart.

Top Publications

  1. ncbi Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease
    Edward G Lakatta
    Gerontology Research Center, Intramural Research Program, Gerontology Research Center, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Circulation 107:139-46. 2003
  2. pmc Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries
    Mei Y Speer
    Department of Bioengineering, University of Washington, Box 355061, 1705 NE Pacific St Foege N330L, Seattle, WA 98195, USA
    Circ Res 104:733-41. 2009
  3. ncbi The uterine spiral arteries in human pregnancy: facts and controversies
    R Pijnenborg
    Department of Obstetrics and Gynaecology, Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven, Belgium
    Placenta 27:939-58. 2006
  4. pmc Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
    G J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Placenta 30:473-82. 2009
  5. ncbi Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
    Thomas Nystrom
    Karolinska Institutet, Department of Internal Medicine, Stockholm South Hospital SE 118 83 Stockholm, Sweden
    Regul Pept 125:173-7. 2005
  6. ncbi Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 43:1239-45. 2004
  7. ncbi Clinical applications of arterial stiffness; definitions and reference values
    Michael F O'Rourke
    St Vincent s Hospital UNSW and St Vincent s Clinic, Sydney, Australia
    Am J Hypertens 15:426-44. 2002
  8. ncbi Distributions of diffuse intimal thickening in human arteries: preferential expression in atherosclerosis-prone arteries from an early age
    Yutaka Nakashima
    Pathophysiological and Experimental Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Virchows Arch 441:279-88. 2002
  9. ncbi Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
  10. pmc Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SK(Ca) channels and caveolin-rich domains
    M Absi
    Faculty of Life Sciences, University of Manchester, Core Technology Facility, Manchester, UK
    Br J Pharmacol 151:332-40. 2007

Research Grants

  1. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
  2. Mark W Chapleau; Fiscal Year: 2015
  3. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
  4. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
  5. Sharon M Moe; Fiscal Year: 2014
  6. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
  7. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
  8. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
  9. Danny A Riley; Fiscal Year: 2014
  10. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010

Detail Information

Publications421 found, 100 shown here

  1. ncbi Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease
    Edward G Lakatta
    Gerontology Research Center, Intramural Research Program, Gerontology Research Center, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Circulation 107:139-46. 2003
  2. pmc Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries
    Mei Y Speer
    Department of Bioengineering, University of Washington, Box 355061, 1705 NE Pacific St Foege N330L, Seattle, WA 98195, USA
    Circ Res 104:733-41. 2009
    ....
  3. ncbi The uterine spiral arteries in human pregnancy: facts and controversies
    R Pijnenborg
    Department of Obstetrics and Gynaecology, Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven, Belgium
    Placenta 27:939-58. 2006
    Uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and for this purpose they are remodelled into highly dilated vessels by the action of invading trophoblast (physiological change)...
  4. pmc Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
    G J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Placenta 30:473-82. 2009
    Physiological conversion of the maternal spiral arteries is key to a successful human pregnancy...
  5. ncbi Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
    Thomas Nystrom
    Karolinska Institutet, Department of Internal Medicine, Stockholm South Hospital SE 118 83 Stockholm, Sweden
    Regul Pept 125:173-7. 2005
    ..In conclusion, we now report a direct vascular action of GLP-1, relaxing conduit vessels independently of NO and the endothelium...
  6. ncbi Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 43:1239-45. 2004
    ..This phenomenon may facilitate forward transmission of potentially deleterious pressure pulsations into the periphery...
  7. ncbi Clinical applications of arterial stiffness; definitions and reference values
    Michael F O'Rourke
    St Vincent s Hospital UNSW and St Vincent s Clinic, Sydney, Australia
    Am J Hypertens 15:426-44. 2002
    ..Stiffening affects predominantly the aorta and proximal elastic arteries, and to a lesser degree the peripheral muscular arteries...
  8. ncbi Distributions of diffuse intimal thickening in human arteries: preferential expression in atherosclerosis-prone arteries from an early age
    Yutaka Nakashima
    Pathophysiological and Experimental Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Virchows Arch 441:279-88. 2002
    Diffuse intimal thickening (DIT) is a thickened intima present in human arteries before atherosclerosis develops and is considered to be related to atherogenesis...
  9. ncbi Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
    ..converted into a rigid material capable of sustaining mechanical force; pathological calcification can occur in arteries and cartilage and other soft tissues...
  10. pmc Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SK(Ca) channels and caveolin-rich domains
    M Absi
    Faculty of Life Sciences, University of Manchester, Core Technology Facility, Manchester, UK
    Br J Pharmacol 151:332-40. 2007
    ..The importance of caveolae in the functioning of IK(Ca) and SK(Ca) channels was investigated...
  11. ncbi Arterial wave reflections and survival in end-stage renal failure
    G M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, Ste Genevieve des Bois, France
    Hypertension 38:434-8. 2001
    The increased effect of arterial wave reflections on central arteries like the common carotid artery seen in end-stage renal failure (ESRF) patients favors myocardial hypertrophy and oxygen consumption and alters coronary blood flow ..
  12. ncbi Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study
    Eamon Dolan
    The ADAPT Centre, Beaumont Hospital, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Hypertension 47:365-70. 2006
    ..89; P=0.47 versus 0.40). AASI is a novel measure of arterial stiffness, which can be readily determined from ambulatory blood pressure recordings and which independently predicts cardiovascular mortality, even in normotensive subjects...
  13. ncbi Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study
    Ronald M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 107:2089-95. 2003
    ..In nondiabetic individuals, increased arterial stiffness is an important cause of cardiovascular disease. Associations between DM-2 and IGM and arterial stiffness have not been systematically investigated...
  14. ncbi Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
    Arndt F Siekmann
    Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 445:781-4. 2007
    ..that Notch signalling is necessary to restrict angiogenic cell behaviour to tip cells in developing segmental arteries in the zebrafish embryo...
  15. ncbi Nitric oxide regulates local arterial distensibility in vivo
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circulation 105:213-7. 2002
    ..We hypothesized that nitric oxide (NO) acting locally regulates arterial stiffness in vivo, and the aim of this experiment was to test this hypothesis in an ovine hind-limb preparation...
  16. pmc Mechanisms of vein graft adaptation to the arterial circulation: insights into the neointimal algorithm and management strategies
    Akihito Muto
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    Circ J 74:1501-12. 2010
    ..Scientific inquiry into venous-specific adaptation mechanisms will ultimately provide improvements in vein graft clinical outcomes...
  17. ncbi Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging
    Edward G Lakatta
    Gerontology Research Center, Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Circulation 107:490-7. 2003
  18. pmc Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice
    Anthony J Donato
    Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA, USA Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, USA Veteran s Affairs Medical Center Salt Lake City, Geriatrics Research Education and Clinical Center, Salt Lake City, UT, USA Department of Exercise and Sports Science, University of Utah, Salt Lake City, UT, USA
    Aging Cell 12:772-83. 2013
    ..Old AL). Lastly, CR normalized age-related changes in the critical nutrient-sensing pathways SIRT-1 and mTOR (P < 0.05 vs. Old AL). Our findings demonstrate that CR is an effective strategy for attenuation of arterial aging. ..
  19. ncbi Medial localization of mineralization-regulating proteins in association with Mönckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification
    C M Shanahan
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Circulation 100:2168-76. 1999
    Calcification of the media of peripheral arteries is referred to as Mönckeberg's sclerosis (MS) and occurs commonly in aged and diabetic individuals...
  20. ncbi Spatial heterogeneity in VEGF-induced vasodilation: VEGF dilates microvessels but not epicardial and systemic arteries and veins
    Roger J Laham
    Angiogenesis Research Center, Department of Medicine and Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Vasc Surg 17:245-52. 2003
    ..120-200 mm in internal diameter) that was partially inhibited by L-NNA, but had no effect on epicardial coronary arteries, systemic arteries, or veins...
  21. ncbi Histomorphology of the placenta and the placental bed of growth restricted foetuses and correlation with the Doppler velocimetries of the uterine and umbilical arteries
    R Madazli
    Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Placenta 24:510-6. 2003
    ..of the placenta and the placental bed and to correlate this with the Doppler study of the uterine and umbilical arteries of intrauterine growth restricted pregnancies...
  22. ncbi Toward functional genomics of flow-induced outward remodeling of resistance arteries
    Jo G R De Mey
    Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Am J Physiol Heart Circ Physiol 288:H1022-7. 2005
    In resistance-sized arteries, a chronic increase in blood flow leads to increases in arterial structural luminal diameter and arterial wall mass...
  23. ncbi NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries
    Alyson A Miller
    Department of Pharmacology, University of Melbourne, Parkville, Victoria 3010, Australia
    Circ Res 97:1055-62. 2005
    ..tested whether the activity, function, and expression of NADPH oxidase differs between rat cerebral and systemic arteries. Superoxide production by basilar (BA), middle cerebral (MCA), carotid (CA), renal (RA), and mesenteric (MA) ..
  24. ncbi Increased ambulatory arterial stiffness index is associated with target organ damage in primary hypertension
    Giovanna Leoncini
    Department of Cardio Nephrology, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Hypertension 48:397-403. 2006
    ..These data strengthen the role of this index as a marker of risk and help to explain the high cardiovascular mortality reported in patients with high ambulatory arterial stiffness index...
  25. ncbi Physiological regulation of penile arteries and veins
    D Prieto
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Int J Impot Res 20:17-29. 2008
    ..Sympathetic nerves maintain flaccidity and tonically released noradrenaline induces vasoconstriction of both arteries and veins through alpha(1)- and alpha(2)-postsynaptic receptors and downregulates its own release and that of ..
  26. doi IFPA Gabor Than Award lecture: Transformation of the spiral arteries in human pregnancy: key events in the remodelling timeline
    L K Harris
    Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
    Placenta 32:S154-8. 2011
    During human pregnancy, the uterine spiral arteries are progressively remodelled to form dilated conduits lacking maternal vasomotor control...
  27. doi A morphometric study concerning the branching points of the main arteries in humans: relationships and correlations
    Eleni Panagouli
    Department of Anatomy, Medical School, University of Athens, Mikras Asias Str 75, Athens, Greece
    Ann Anat 193:86-99. 2011
    An adequate quantity of data on the branching points and important arterial segments of the main arteries in humans is missing...
  28. ncbi Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality in Ohasama, Japan
    Masahiro Kikuya
    Tohoku University Graduate School of Medicine and Pharmaceutical Science, 1 1 Seiryomachi, Sendai, Japan
    Stroke 38:1161-6. 2007
    ..We investigated the prognostic value of AASI and PP in relation to fatal outcomes...
  29. ncbi Galen: on blood, the pulse, and the arteries
    Michael Boylan
    Department of Philosophy, Marvmount University, 2807 N Globe Road, Arlington, VA 22207, USA
    J Hist Biol 40:207-30. 2007
    This essay examines several important issues regarding Galen's depiction of the physiology of the arteries. In the process some of Galen's supporting doctrines on the blood and pulse will also be discussed in the context of a coherent ..
  30. doi Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries
    Benjamin M Hogan
    Hubrecht Institute KNAW and University Medical Centre, Utrecht, and Centre for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Development 136:4001-9. 2009
    The development of arteries, veins and lymphatics from pre-existing vessels are intimately linked processes controlled by a number of well-studied reiteratively acting signalling pathways...
  31. ncbi Osteopontin expression in cardiovascular diseases
    C M Giachelli
    Department of Pathology SJ 60, University of Washington, School of Medicine, Seattle 98195, USA
    Ann N Y Acad Sci 760:109-26. 1995
    ....
  32. pmc Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques
    C M Giachelli
    Department of Pathology SJ 60 University of Washington School of Medicine, Seattle 98195
    J Clin Invest 92:1686-96. 1993
    ..Using immunochemistry and in situ hybridization, we found that medial smooth muscle cells (SMC) in uninjured arteries contained very low levels of osteopontin protein and mRNA...
  33. ncbi Aldosterone-to-renin ratio, arterial stiffness, and the response to aldosterone antagonism in essential hypertension
    Azra Mahmud
    Department of Therapeutics and Hypertension Clinic, St James s Hospital, Dublin, Ireland
    Am J Hypertens 18:50-5. 2005
    ..As aldosterone reduces arterial compliance, we examined the relationship between aldosterone-to-renin ratio, aortic blood pressure (BP), arterial stiffness, and the effect of spironolactone in a hypertensive population...
  34. pmc The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells
    Mirko Corselli
    Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, UCLA and Orthopaedic Hospital, Los Angeles, California 90095, USA
    Stem Cells Dev 21:1299-308. 2012
    ..In conclusion, we demonstrate the co-existence of 2 separate perivascular MSC progenitors: pericytes in capillaries and microvessels and adventitial cells around larger vessels...
  35. pmc Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation
    Shane P Herbert
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Science 326:294-8. 2009
    ..Thus, directional control of progenitor migration drives arterial-venous segregation and generation of separate parallel vessels from a single precursor vessel, a process essential for vascular development...
  36. ncbi Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel
    V P Deenadayalu
    Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, Ohio 45435-0927, USA
    Am J Physiol Heart Circ Physiol 281:H1720-7. 2001
    ..studies demonstrated that testosterone or dihydrotestosterone (a nonaromatizable metabolite) relaxed these arteries by an endothelium-independent mechanism involving potassium efflux...
  37. ncbi Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases
    Michel E Safar
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Circulation 107:2864-9. 2003
  38. ncbi Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease
    Dan Wang
    Department of Nephrology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Kidney Int 64:1381-8. 2003
    ..We investigated the relationship between endothelial dysfunction and nitric oxide generation in hypertension and chronic renal insufficiency (CRI) in ADPKD...
  39. ncbi Ambulatory arterial stiffness index derived from 24-hour ambulatory blood pressure monitoring
    Yan Li
    Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Institute of Hypertension, Shanghai Second Medical University, Shanghai, China
    Hypertension 47:359-64. 2006
    ..Pending additional validation in outcome studies, normal values of AASI are probably <0.50 and 0.70 in young and older subjects, respectively...
  40. pmc Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis
    Jeltsje S Cnossen
    Department of General Practice, Academic Medical Center, Amsterdam, The Netherlands
    CMAJ 178:701-11. 2008
    ..We investigated the predictive accuracy of all uterine artery Doppler indices for both conditions in the first and second trimesters...
  41. ncbi A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    M Yanagisawa
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nature 332:411-5. 1988
    ..Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system...
  42. ncbi Lead-induced hypertension: possible role of endothelial factors
    F Khalil-Manesh
    Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048
    Am J Hypertens 6:723-9. 1993
    ....
  43. ncbi Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
    H U Wang
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 93:741-53. 1998
    The vertebrate circulatory system is composed of arteries and veins. The functional and pathological differences between these vessels have been assumed to reflect physiological differences such as oxygenation and blood pressure...
  44. ncbi Determination of age-related increases in large artery stiffness by digital pulse contour analysis
    S C Millasseau
    Department of Clinical Pharmacology, St Thomas Hospital, Centre for Cardiovascular Biology and Medicine, King s College London, Lambeth Palace Road, London SE1 7EH, UK
    Clin Sci (Lond) 103:371-7. 2002
    ..The timing of these components of the DVP is determined by PWV in the aorta and large arteries. SI(DVP) was, therefore, expected to provide a measure of stiffness similar to PWV...
  45. ncbi Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity
    Li Ru You
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 435:98-104. 2005
    b>Arteries and veins are anatomically, functionally and molecularly distinct...
  46. ncbi Ageing of the conduit arteries
    S E Greenwald
    Pathology Group, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London
    J Pathol 211:157-72. 2007
    Conduit arteries become stiffer with age due to alterations in their morphology and the composition of the their major structural proteins, elastin and collagen...
  47. pmc Increased apoptosis in first trimester extravillous trophoblasts from pregnancies at higher risk of developing preeclampsia
    Guy St J Whitley
    Developmental and Endocrine Signalling Centre, Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London, UK
    Am J Pathol 170:1903-9. 2007
    ..Although the cause is unknown, inadequate invasion and remodeling of maternal uterine arteries by extravillous trophoblasts (EVTs) in the first trimester is a common feature...
  48. doi Validation of a one-dimensional model of the systemic arterial tree
    Philippe Reymond
    Laboratory of Hemodynamics and Cardiovascular Technology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 297:H208-22. 2009
    A distributed model of the human arterial tree including all main systemic arteries coupled to a heart model is developed...
  49. ncbi Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    Arterioscler Thromb Vasc Biol 18:1400-7. 1998
    High doses of warfarin cause focal calcification of the elastic lamellae in the media of major arteries and in aortic heart valves in the rat...
  50. ncbi Vascular development: from precursor cells to branched arterial and venous networks
    Anne Eichmann
    INSERM U36, College de France, Paris, France
    Int J Dev Biol 49:259-67. 2005
    ..cells in the embryo, of their assembly into the primary vascular plexus and of the remodeling of this plexus into arteries and veins...
  51. ncbi Arterial stiffness and cardiovascular risk factors in a population-based study
    J Amar
    Service de Médecine Interne et d Hypertension artérielle, CHU Purpan Toulouse, France
    J Hypertens 19:381-7. 2001
    ..To determine the relationships between pulse wave velocity (PWV), an estimate of arterial distensibility and cardiovascular risk factors...
  52. ncbi Comparison of ultrasonic energy, bipolar thermal energy, and vascular clips for the hemostasis of small-, medium-, and large-sized arteries
    K L Harold
    Department of Surgery, Carolinas Medical Center, 1000 Blythe Boulevard, MEB 601, Charlotte, NC 28203, USA
    Surg Endosc 17:1228-30. 2003
    ..The purpose of this study was to compare the bursting pressure of arteries sealed with ultrasonic coagulating shears (UCS), electrothermal bipolar vessel sealer (EBVS), titanium ..
  53. doi Arterial function in youth: window into cardiovascular risk
    Bo Fernhall
    Exercise and Cardiovascular Research Laboratory, Kinesiology and Community Health Department, College of Applied Health Sciences, University of Illinois at Urbana Champaign, Champaign, Illiois, USA
    J Appl Physiol (1985) 105:325-33. 2008
    ..Future studies need to focus on the mechanism by which exercise and diet improve arterial function, the most effective types of diet and exercise, and if intervening in childhood leads to favorable outcomes in adulthood...
  54. doi Genetics and pathophysiology of arterial stiffness
    Patrick Lacolley
    INSERM, U961, Faculte de Medecine, 9 Avenue de la Forêt de Haye, B P 184, 54500 Vandoeuvre Les Nancy Cedex, France
    Cardiovasc Res 81:637-48. 2009
    ....
  55. ncbi Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries: role of extracellular signal-regulated kinases
    R M Touyz
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 17:907-16. 1999
    ..This study investigates the growth effects and associated signaling pathways of angiotensin II (Ang II) in human vascular smooth muscle cells...
  56. pmc EDHF, NO and a prostanoid: hyperpolarization-dependent and -independent relaxation in guinea-pig arteries
    M Tare
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Br J Pharmacol 130:605-18. 2000
    ..a prostanoid (PG) to endothelium-dependent hyperpolarization and relaxation were assessed in coronary and mammary arteries of guinea-pigs by integration of the responses evoked during discrete applications of acetylcholine (ACh)...
  57. ncbi Phosphate regulation of vascular smooth muscle cell calcification
    S Jono
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Circ Res 87:E10-7. 2000
    ..The full text of this article is available at http://www.circresaha.org...
  58. ncbi F-18 FDG uptake in the large arteries: a new observation
    M Yun
    Department of Nuclear Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Clin Nucl Med 26:314-9. 2001
    ..The presence of vascular FDG uptake was assessed in the abdominal aorta, iliac, and proximal femoral arteries on the 132 whole-body scans, whereas only the femoral and the popliteal arteries were examined on the leg scans...
  59. ncbi Endothelium-derived nitric oxide regulates arterial elasticity in human arteries in vivo
    S Kinlay
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Hypertension 38:1049-53. 2001
    ..02). NO, an endothelium-derived vasodilator, augments arterial elasticity in the human brachial artery. Loss of constitutively released NO associated with cardiovascular risk factors may adversely affect arterial elasticity in humans...
  60. ncbi Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly
    Zorina S Galis
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Circ Res 90:251-62. 2002
    ..Our future potential ability to control vascular remodeling via regulation of MMPs will also depend on reaching a consensus of what is indeed "good" or "bad" vascular remodeling, concepts that have continued to evolve and change...
  61. ncbi Nitric oxide donor sodium nitroprusside dilates rat small arteries by activation of inward rectifier potassium channels
    Rudolf Schubert
    Institute of Physiology, University Rostock, Rostock, Germany
    Hypertension 43:891-6. 2004
    ..The hypothesis that K(IR) channels are involved in sodium nitroprusside (SNP)-induced dilation of rat-tail small arteries was tested. SNP relaxed tail small arteries with an EC50 of 2.6x10(-8) mol/L...
  62. ncbi Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries
    Scott Earley
    Department of Pharmacology, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT, USA
    Circ Res 95:922-9. 2004
    Local control of cerebral blood flow is regulated in part through myogenic constriction of resistance arteries. Although this response requires Ca2+ influx via voltage-dependent Ca2+ channels secondary to smooth muscle cell depolarization,..
  63. ncbi Arterial stiffness: pathophysiology and clinical impact
    Gerard M London
    Nephrology Department, Manhes Hospital, Ste Genevieve des Bois, France
    Clin Exp Hypertens 26:689-99. 2004
    ..stiffness, whose role is to dampen pressure and flow oscillations and to transform pulsatile flow and pressure in arteries into a steady flow and pressure in peripheral tissues. Stiffness is the reciprocal value of D...
  64. ncbi Priming and remodelling of human placental bed spiral arteries during pregnancy--a review
    F Lyall
    University of Glasgow, Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK
    Placenta 26:S31-6. 2005
    ..placentation and to provide a progressive increase in blood supply to the growing fetus, the uterine spiral arteries must undergo considerable alterations...
  65. ncbi Impact of oxidative stress on arterial elasticity in patients with atherosclerosis
    Jaak Kals
    Department of Biochemistry, Center of Molecular and Clinical Medicine, University of Tartu, Tartu, Estonia
    Am J Hypertens 19:902-8. 2006
    Alterations in the elastic behavior of arteries is an early sign of vascular damage in atherogenesis and may be promoted by oxidative stress (OxS)...
  66. ncbi Functional arterial and venous fate is determined by graded VEGF signaling and notch status during embryonic stem cell differentiation
    Fredrik Lanner
    Department of Cell and Molecular Biology, Karolinska Institutet, Box 285, SE 17177 Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 27:487-93. 2007
    The aim of this work was to develop a mouse embryonic stem (ES) cell system addressing the early specification of the developing vasculature into functional arteries and veins.
  67. ncbi Impact of smoking and smoking cessation on arterial stiffness and aortic wave reflection in hypertension
    Noor A Jatoi
    Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Hypertension 49:981-5. 2007
    ..Although smokers have stiffer arteries, whether smoking cessation is associated with reduced arterial stiffness is not known...
  68. doi Smooth muscle apoptosis and vascular remodeling
    Vyacheslav A Korshunov
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14586, USA
    Curr Opin Hematol 15:250-4. 2008
    ..In normal blood vessels apoptosis counteracts cell division, whereas apoptosis is especially crucial for regulating vascular remodeling during cardiovascular diseases...
  69. doi First-trimester uterine artery Doppler indices in term and preterm pre-eclampsia
    K Melchiorre
    Academic Department of Obstetrics and Gynaecology, St George s University of London, London, UK
    Ultrasound Obstet Gynecol 32:133-7. 2008
    ..To assess the relationship between first-trimester uterine artery Doppler measurements and the development of term and preterm pre-eclampsia...
  70. doi Critical appraisal of targeted ultrasound contrast agents for molecular imaging in large arteries
    Liselotte M Kornmann
    Department of Biophysics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Ultrasound Med Biol 36:181-91. 2010
    ..For large arteries, however, successful application is less obvious...
  71. ncbi Brachial-ankle pulse wave velocity as an index of central arterial stiffness
    Shoko Tsuchikura
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    J Atheroscler Thromb 17:658-65. 2010
    Stiffness of the central arteries plays an important role in the pathophysiology of cardiovascular disease, and pulse wave velocity (PWV) of the aorta has been used as the standard measure of central arterial stiffness...
  72. doi The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling
    Monica Corada
    IFOM, The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Dev Cell 18:938-49. 2010
    ..We propose that early and sustained beta-catenin signaling prevents correct endothelial cell differentiation, altering vascular remodeling and arteriovenous specification...
  73. doi Numerical modeling of stress in stenotic arteries with microcalcifications: a micromechanical approximation
    Jonathan F Wenk
    Department of Mechanical Engineering, University of California Berkeley, CA 94720 1740, USA
    J Biomech Eng 132:091011. 2010
    Most finite element models of atherosclerotic arteries do not account for the heterogeneity of the plaque constituents at the microscale...
  74. ncbi Aging and arterial stiffness
    Hae Young Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Circ J 74:2257-62. 2010
    ..are luminal enlargement with wall thickening and a reduction of elastic properties at the level of large elastic arteries. Longstanding arterial pulsation in the central artery causes elastin fiber fatigue and fracture...
  75. doi Impaired resistance artery function in patients with end-stage renal disease
    Natallia Luksha
    Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Sci (Lond) 120:525-36. 2011
    We investigated an effect of uraemia on structural and functional features of human resistance vasculature. Arteries (≈ 200 μm) isolated from subcutaneous fat biopsies obtained from 35 ESRD (end-stage renal disease) patients starting ..
  76. ncbi Imatinib mesylate-incorporated nanoparticle-eluting stent attenuates in-stent neointimal formation in porcine coronary arteries
    Seigo Masuda
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Atheroscler Thromb 18:1043-53. 2011
    ....
  77. doi Experimental validation of a pulse wave propagation model for predicting hemodynamics after vascular access surgery
    W Huberts
    Eindhoven University of Technology, Department of Biomedical Engineering, The Netherlands
    J Biomech 45:1684-91. 2012
    ..Furthermore, it was found that in the analysis output uncertainties, resulting from input uncertainties, cannot be neglected and should thus be considered...
  78. pmc Mechanisms of endothelial dysfunction in resistance arteries from patients with end-stage renal disease
    Leanid Luksha
    Division of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital, Department of Clinical Science, Intervention and Technology, Stockholm, Sweden
    PLoS ONE 7:e36056. 2012
    The study focuses on the mechanisms of endothelial dysfunction in the uremic milieu. Subcutaneous resistance arteries from 35 end-stage renal disease (ESRD) patients and 28 matched controls were studied ex-vivo...
  79. doi Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction
    Olga Zavaritskaya
    Centre for Biomedicine and Medical Technology Mannheim, Research Division Cardiovascular Physiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Hypertension 61:151-9. 2013
    ..the hypothesis that KCNQ channels contribute to periadventitial vasoregulation in peripheral skeletal muscle arteries by perivascular adipose tissue and that they represent novel targets to rescue periadventitial vascular ..
  80. doi Outflow boundary conditions for 3D simulations of non-periodic blood flow and pressure fields in deformable arteries
    I E Vignon-Clementel
    INRIA Paris Rocquencourt, Le Chesnay, France
    Comput Methods Biomech Biomed Engin 13:625-40. 2010
    The simulation of blood flow and pressure in arteries requires outflow boundary conditions that incorporate models of downstream domains...
  81. ncbi Fatty acids modulate the composition of extracellular matrix in cultured human arterial smooth muscle cells by altering the expression of genes for proteoglycan core proteins
    U Olsson
    Wallenberg Laboratory for Cardiovascular Research, Faculty of Medicine, University of Gothenburg, Sweden
    Diabetes 48:616-22. 1999
    ..and atherosclerosis, there are alterations of the extracellular matrix (ECM) in the intima of small and large arteries. High levels of circulating nonesterified fatty acids (NEFAs) are present in insulin resistance and type 2 ..
  82. ncbi [Doppler ultrasound assisted hemorrhoid artery ligation. A new therapy in symptomatic hemorrhoids]
    S Arnold
    Chirurgische Abteilung, Krankenhaus der Stadt Bludenz, Spitalsgasse 13, 6700 Bludenz, Osterreich
    Chirurg 73:269-73. 2002
    ..By a specially designed proctoscope coupled with a Doppler transducer, the hemorrhoidal arteries are looked for and ligated. All stages of hemorrhoid were treated...
  83. ncbi Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites
    Leanid Luksha
    Institution for Clinical Science, Intervention and Technology, Department of Obstetrics and Gynecology, Karolinska Institute, Karolinska University Hospital Huddinge Campus, 14186 Stockholm, Sweden
    Am J Physiol Regul Integr Comp Physiol 294:R510-9. 2008
    ..We aimed to assess endothelial function and morphology in arteries from NP and PE with particular focus on EDHF...
  84. doi Two-center experience in the treatment of hemorrhoidal disease using Doppler-guided hemorrhoidal artery ligation: functional results after 1-year follow-up
    Piotr Wałega
    3rd Department of General Surgery, Jagiellonian University School of Medicine, Pradnicka 35 37 31 202, Krakow, Poland
    Surg Endosc 22:2379-83. 2008
    ..The aim of our study was to evaluate the clinical effectiveness and functional results of DGHAL as estimated by means of anorectal manometry...
  85. ncbi Renal and vascular protective effects of cilnidipine in patients with essential hypertension
    Satoshi Morimoto
    Department of Internal Medicine, Ohmihachiman City Hospital, Japan
    J Hypertens 25:2178-83. 2007
    ..This study compares the effects on renal and vascular endothelial functions and arterial stiffness of monotherapy regimens of amlodipine, an L-type calcium antagonist, and cilnidipine, in patients with essential hypertension...
  86. pmc Assembly and patterning of the vascular network of the vertebrate hindbrain
    Misato Fujita
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 138:1705-15. 2011
    ..a second wave of dorsal sprouting from the primordial hindbrain channels gives rise to angiogenic central arteries that penetrate into and innervate the hindbrain...
  87. doi Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness
    Christian F Clarenbach
    Pulmonary Clinic, University Hospital Zurich, Zurich, Switzerland
    Hypertens Res 35:228-33. 2012
    ..Therefore, digital pulse wave analysis may be a valuable tool to estimate arterial stiffness in large clinical studies...
  88. ncbi Cardio-ankle vascular index (CAVI) as a novel indicator of arterial stiffness: theory, evidence and perspectives
    Kohji Shirai
    Internal Medicine, Sakura Hospital, School of Medicine, Toho University
    J Atheroscler Thromb 18:924-38. 2011
    ..This review covers the principles of CAVI and our current knowledge about CAVI, focusing on its roles and future outlook...
  89. ncbi Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age
    S Meaume
    Geriatrics Department of Charles-Foix Hospital, Limeil-Brevannes, France
    Arterioscler Thromb Vasc Biol 21:2046-50. 2001
    ..In subjects 70 to 100 years old, aortic PWV is a strong, independent predictor of cardiovascular death, whereas systolic or pulse pressure was not. This prospective result will need to be confirmed in an intervention trial...
  90. ncbi In-stent restenosis in small coronary arteries: impact of strut thickness
    Carlo Briguori
    Laboratory of Interventional Cardiology, Vita e Salute University School of Medicine, San Raffaele Hospital, Milan, Italy
    J Am Coll Cardiol 40:403-9. 2002
    OBJECTIVES; We sought to evaluate whether strut thickness may impact the restenosis rate after stent implantation in small coronary arteries.
  91. ncbi Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Hypertension 44:112-6. 2004
  92. ncbi Arterial adaptations to chronic changes in haemodynamic function: coupling vasomotor tone to structural remodelling
    Dorota Dajnowiec
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Sci (Lond) 113:15-23. 2007
    Healthy mature arteries are usually extremely quiescent tissues with cell proliferation rates much below 1%/day and with extracellular matrix constituents exhibiting half-lives of years to decades...
  93. ncbi Low nanomolar concentration of mercury chloride increases vascular reactivity to phenylephrine and local angiotensin production in rats
    Giulia Alessandra Wiggers
    Department of Physiological Sciences, Federal University of Espirito Santo, Brazil
    Comp Biochem Physiol C Toxicol Pharmacol 147:252-60. 2008
    ..Pressor responses to phenylephrine (PHE) were investigated in perfused rat tail arteries before and after treatment with 6 nM HgCl2 during 1 h, in the presence (E+) and absence (E-) of endothelium, ..
  94. ncbi Possible involvement of altered arginase activity, arginase type I and type II expressions, and nitric oxide production in occurrence of intimal hyperplasia in premenopausal human uterine arteries
    Galina Vasileva Marinova
    Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Japan
    J Pharmacol Sci 106:385-93. 2008
    ..of arginase I and II are involved in the occurrence of intimal hyperplasia in premenopausal human uterine arteries. They were obtained from thirty-four patients undergoing total abdominal hysterectomy with informed consent for ..
  95. pmc CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury
    Guohong Li
    Cardiovascular Division, Robert M Berne Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, USA
    Am J Pathol 172:1141-52. 2008
    ..and Gr-1(+) monocytes (at 3 days) and the late accumulation of Mac-2(+) macrophages (at 28 days) in the denudated arteries; it also reduced the exaggerated neointima formation at 28 days...
  96. pmc Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos
    Alexandre Trindade
    Centro de Informatica do Instituto Superior de Agronomia CIISA, Lisbon Technical University, Lisbon, Portugal
    Blood 112:1720-9. 2008
    ..These results establish the role of Dll4 in arterial identity determination, and regulation of angiogenesis subject to dose and location...
  97. doi Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries
    G A Wiggers
    Departamento de Farmacologia, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain
    Am J Physiol Heart Circ Physiol 295:H1033-H1043. 2008
    ..exposure to low mercury concentrations on endothelium-dependent responses in aorta and mesenteric resistance arteries (MRA). Wistar rats were treated with mercury chloride (1st dose 4.6 microg/kg, subsequent dose 0.07 microg.kg(-1)...
  98. pmc Blood supply in melanoma xenografts is governed by the morphology of the supplying arteries
    Jon Vidar Gaustad
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Neoplasia 11:277-85. 2009
    Tumor blood supply was related to the morphology of the tumor microvasculature and the supplying arteries (SAs) of A-07-GFP and D-12-GFP melanoma xenografts growing in window chamber preparations in BALB/c nu/nu mice...
  99. pmc Specification of arterial, venous, and lymphatic endothelial cells during embryonic development
    Tsutomu Kume
    Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Histol Histopathol 25:637-46. 2010
    ....
  100. pmc Proteomic evaluation of biological nanoparticles isolated from human kidney stones and calcified arteries
    Farooq A Shiekh
    Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Acta Biomater 6:4065-72. 2010
    ..These elements, including EF-Tu, can be used as biomarkers to further define the processes that mediate propagation of biological NPs and their contribution to disease...
  101. doi Greater arterial stiffness in polycystic ovary syndrome (PCOS) is an obesity--but not a PCOS-associated phenomenon
    I J Ketel
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Vrije Universiteit Medical Centre VU, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 95:4566-75. 2010
    ..Polycystic ovary syndrome (PCOS) and obesity are associated with cardiovascular disease, but it is unclear to what extent they contribute independently. Arterial stiffness might link obesity and PCOS to cardiovascular diseases...

Research Grants78

  1. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..devastating disease with inflammatory cell mediated damage to all tissue layers of medium and large vessel arteries. Inflammatory vasculitis (IVS) ranges from rarer disorders such as TKD (2...
  2. Mark W Chapleau; Fiscal Year: 2015
    ..pro- and anti- oxidant molecules will be measured in the relevant brain regions, sensory ganglia, and peripheral arteries. The significance of identifying nervous system CGRP/RAMP1 receptors as positive modulators of autonomic control ..
  3. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..Diffuse vascular dysfunction involving small and medium sized arteries may play a central role in causing multiorgan injury...
  4. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..prenatal ductal constriction demonstrated a decrease in NO release and increase in oxidative stress in pulmonary arteries. Activation of NADPH oxidase and uncoupled activity of endothelial nitric oxide synthase (eNOS) are sources of ..
  5. Sharon M Moe; Fiscal Year: 2014
    ..PUBLIC HEALTH RELEVANCE: In patients with chronic kidney disease there is abnormal bone and hardening of the arteries. Both of these problems may be linked...
  6. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..smooth muscle cells (vSMCs) and buildup of cholesterol and extracellular matrix within the inner lining of arteries. Clinical disease results from occlusion of vessels that feed the heart, brain, or extremities...
  7. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..an aberrant maternal immune response that restricts CTB invasion and leads to impaired remodeling of the spiral arteries into large bore low resistance vessels necessary to increase uterine blood flow to the developing feto-placental ..
  8. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..a syndrome characterized by obstructive vascular remodeling, inflammation and vasoconstriction of small pulmonary arteries. Despite recent therapeutic advances, 1-year mortality rates remains high (~15%)...
  9. Danny A Riley; Fiscal Year: 2014
    ..Exposing humans to damaging vibration in a research study is unethical so animal model surrogates with nerves and arteries similar in structure and function to those in human fingers are essential...
  10. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..effective pharmaceutical strategy to reduce the incidence of restenosis due to intimal hyperplasia in peripheral arteries. Therefore, the relevance of this proposal lies in its potential to improve patency of lower extremity ..
  11. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..At the same time, activation of RAS and XO in resistance arteries leads to impairment in endothelium- dependent vasodilation...
  12. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..Accumulation of cADPR in pulmonary arteries has also been implicated as the trigger for hypoxic pulmonary vasoconstriction (HPV)...
  13. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..negative regulation of KCNQ channels underlies the vasoconstrictor actions of low [AVP] (30 pM) in rat mesenteric arteries. No previous studies have examined how KCNQ channels may be regulated by vasoactive hormones, the signal ..
  14. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..extracellular matrix (EM) have a negative impact on the physiology and function of end target organs such as the arteries, heart and kidneys in hypertension...
  15. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..The vessels will then be implanted as interposition grafts in the carotid arteries of living sheep, and will be imaged in 500[unreadable]m resolution to follow the tissue regeneration and function...
  16. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..it may lead to global myocardial ischemia by compromising the aortic valve and blood flow through the coronary arteries. Rupture of the aorta is more rare but almost always associated with a 100% mortality...
  17. Linda M Graham; Fiscal Year: 2014
    ..LysoPC inhibits EC migration in vitro, and hypercholesterolemia reduces EC migration into injured arteries and onto grafts...
  18. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
    ..confirm these findings in vivo by examining the vascular morphological and functional changes of large conduit arteries and the microvasculature associated with aldosterone-induced autophagy in mouse models of G6PD deficiency, G6PD ..
  19. HUA LINDA CAI; Fiscal Year: 2016
    ..shares some similarity with endothelium regulation of vascular smooth muscle relaxation and signaling in conduit arteries. Cardiac I/R injury is a major clinical problem with unclear molecula mechanisms, and therefore lack of new ..
  20. Devendra K Agrawal; Fiscal Year: 2016
    ..by applicant): Epicardial adipose tissue (EAT) is present in close proximity to the adventitia of the coronary arteries and the underlying myocardium, and functions as both endocrine organ and inflammatory tissue, secreting hormones, ..
  21. Edward O McFalls; Fiscal Year: 2016
    ..heart is transiently stressed by increased work load demands, by spasm or fluctuating thrombosis in one of the arteries prior to its complete closure...
  22. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..Our team is composed of investigators in 4 different academic institutions in 3 different states, with enormous expertise in all aspects of this proposal. ..
  23. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..We have documented the presence of PSA-NCAM in the glycocalyx of human vascular endothelial cells in arteries, veins and lymphatics of all organs (10 organ systems) studied...
  24. Danny J Schust; Fiscal Year: 2016
    ..TB (EVCTB), which invade deeply, interact with maternal decidual immune cells, and remodel the spiral arteries. Both TB subsets are in direct contact with maternal blood and maternal immune cells and both are derived from an ..
  25. James D West; Fiscal Year: 2016
    ..This chronic inflammatory state in precapillary pulmonary arteries leads to PAH through loss of normal vasoreactivity, increased formation of thrombi, and a predisposition to ..
  26. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..interaction that must contribute to various aspects of pregnancy, including remodeling of the uterine spiral arteries to increase blood flow to the developing fetus, implantation of the blastocyst (16 cell stage embryo) into the ..
  27. Mouse Models of Non-Syndromic Cardiac Progeria
    Ali J Marian; Fiscal Year: 2012
    ..D300N is associated with degenerative disease involving myocardium, conduction system, valves and the coronary arteries, while the p.R644C is the most common cause of cardiolaminopathy...
  28. EDWARD CHARLES DEMPSEY; Fiscal Year: 2014
    ..Smooth muscle cells in the walls of lung arteries may grow abnormally in response to smoke and hypoxia, leading to a reduction in vessel diameter and increased ..
  29. Mechanism and therapy for arteriovenous malformation
    Suk Paul Oh; Fiscal Year: 2013
    ..hemorrhagic telangiectasia (HHT), an inherited rare blood disease, contains arteriovenous malformation (AVM)-arteries and vein are directly connected without capillaries in between them-in various organs in a very high frequency ..
  30. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
    ..Ideal intervention for these babies will correct the vascular dysfunction in pulmonary arteries antenatally to restore normal adaptation to the lungs...
  31. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    ..understanding how physiological ECM compliance inhibits vascular smooth muscle cell proliferation, and how this control can be overcome by pathological stiffening of arteries, has the potential to be a significant biomedical advance.
  32. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..CVD that ascends from contracting skeletal muscle into respective feed arteries (ascending vasodilation;AVD) is an essential component of exercise hyperemia...
  33. SMOOTH MUSCLE MYOSIN PHOSPHATASE SUBUNIT ISOFORMS
    Steven A Fisher; Fiscal Year: 2013
    ..g. portal vein and mesenteric resistance arteries, and skipped in the slow (tonic) smooth muscle of the large arteries and veins...
  34. STRUCTURE AND FUNCTION OF HEPARIN COFACTOR II
    Douglas M Tollefsen; Fiscal Year: 2010
    ..Hirudin-binding and chromogenic substrate assays will be used to examine arteries of HCII-/- mice for evidence of increased thrombin activity during neointima formation or development of ..
  35. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..Middle cerebral arteries from 5 autopsies and surgically resected cerebral cortex from 10 epilepsy patients will be used as control...
  36. Plasminogen activators and NMDA after brain injury
    William M Armstead; Fiscal Year: 2012
    ..Cerebral blood flow (CBF) falls and pial arteries constrict more in newborn versus juvenile pigs after fluid percussion brain injury (FPI), supporting the idea ..
  37. Moti L Kashyap; Fiscal Year: 2014
    ..of HDL) to facilitate cholesterol efflux which removes excess cholesterol from peripheral tissues (such as arteries) and anti-inflammatory properties...
  38. George L King; Fiscal Year: 2016
    ..C (PKC), specifically the 21/2 and 4 isoforms, and induce "selective insulin resistance" in the microvessels or arteries of diabetic or insulin resistant animals...
  39. Redox Regulation of SERCA by Nitric Oxide
    Richard A Cohen; Fiscal Year: 2013
    ..by applicant): Because of the high levels of reactive oxygen and nitrogen species (ROS/RNS) present in diseased arteries, the function of endothelium-derived nitric oxide (7NO) is decreased, and this contributes to the growth of ..
  40. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura V Gonzalez Bosc; Fiscal Year: 2012
    ..The hypothesis is that CH activates NFATc3 in PASMC to mediate hypertrophy and enhance contractility of pulmonary arteries (PA) contributing to PAH. Specific Aim 1: To determine the role of NFATc3 in CH-induced PASMC hypertrophy and PAH...
  41. The role of the orphan receptor tyrosine kinase Ros1 in vascular disease
    ZIAD ANWAR ALI; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Hardening and narrowing of the arteries, known as atherosclerosis, can lead to such devastating events such as heart attack and stroke...
  42. Rosalind J Wright; Fiscal Year: 2015
    ..we will archive and extract genomic DNA from the 3 target tissues (umbilical cord blood, placentas, umbilical arteries)...
  43. Gadiparthi N Rao; Fiscal Year: 2015
    ..Atherosclerotic arteries produce 15(S)-HETE as a major 15- LOX product of AA...
  44. Alan D Cherrington; Fiscal Year: 2016
    ..hepatic vein, as well as in other vessels and sites as needed (splenic and jejunal veins, carotid and vertebral arteries, the 3rd ventricle etc.)...
  45. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..However, these approaches do not possess the resolution necessary to detect early lesions, and imaging of arteries located deep in the body, such as the aorta, can be difficult due to the presence of connective tissue and fat...
  46. Lawrence D Longo; Fiscal Year: 2014
    ..In cerebral arteries, we will test hypotheses regarding Oi-adrenergic-mediated signal transduction mechanisms for both Ca^*-dependent ..
  47. WILLIAM BRYSON CAMPBELL; Fiscal Year: 2014
    ..It relax arteries, in part, by activating apamin-sensitive, small conductance, calcium-activated potassium (SKCa) channels and ..
  48. Treatment of Acute Coronary Syndromes with Recombinant LCAT Infusion
    BRIAN ROBERT KRAUSE; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The "hallmark" of atherosclerosis is the accumulation of cholesterol in arteries, resulting in plaque which can lead to a heart attack (myocardial infarction (MI))...
  49. Toll-like receptor signaling in pathogenesis of pulmonary hypertension
    Yabing Chen; Fiscal Year: 2013
    ..Hypoxia induces PAH, which comprises structural remodeling of pulmonary arteries. Recently studies have found that mice deficient in Toll- like receptor 4 (TLR4) are susceptible to lethal ..
  50. WILLIAM BRYSON CAMPBELL; Fiscal Year: 2015
    ..In pM concentrations, AII relaxes adrenal arteries by two mechanisms...
  51. Andrew J Morris; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Ischemic heart disease, caused by atherosclerosis of the coronary arteries, remains the most frequent cause of mortality among Veterans despite extensive investigation into its pathobiology, the ..
  52. Cecilia M Giachelli; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Vascular calcification, commonly known as "hardening of the arteries", is a major risk factor and independent predictor of cardiovascular mortality in the general population as well as high-risk ..
  53. Calcium wave propagation along microvascular endothelial tubes
    MATTHEW JOHN SOCHA; Fiscal Year: 2012
    ..the coordination of activity among endothelial cells (ECs) and smooth muscle cell (SMCs) of arterioles and feed arteries (FA) that comprise microvascular resistance networks...
  54. Release of FGF1 and Pathology of Angiogenesis
    Igor Prudovsky; Fiscal Year: 2010
    ..Copper chelation known to repress the release of FGF1 and IL11 in vitro, inhibits the restenosis in rat arteries and development of adjuvant induced arthritis in rats...
  55. AMP-activated protein kinase in the ischemic heart
    Lawrence H Young; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: People with hardening of the arteries or coronary artery disease can develop heart attacks from a lack of blood flow and oxygen delivery to their heart ..
  56. Vinicio A de Jesus Perez; Fiscal Year: 2016
    ..Patients with PAH demonstrate progressive narrowing and loss of small distal pulmonary arteries without significant compensatory vascular regeneration indicating that a defect in pulmonary angiogenesis is ..
  57. HIGH SALT DIET, ANGIOTENSIN II, AND MICROVESSEL DILATION
    Julian H Lombard; Fiscal Year: 2012
    ..of ANG II, namely the maintenance of normal vascular relaxation by preventing oxidative stress in resistance arteries. PUBLIC HEALTH RELEVANCE: A growing body of evidence indicates that elevated dietary salt intake leads to ..
  58. Integrated MRI-Based Examination for Evaluation of Peripheral Arterial Disease
    Felix W Wehrli; Fiscal Year: 2010
    ..PAD's clinical manifestations are caused by stenosing of the major arteries supplying the lower extremities (iliac, femoral and popliteal arteries)...
  59. Cthrc1 function as a novel TGF-beta antagonist in the vasculature
    Volkhard Lindner; Fiscal Year: 2013
    ..Transgenic mice overexpressing Cthrc1 have brittle bones due a lack of collagenous bone matrix, and their arteries are remarkably resistant to neointimal lesion formation upon injury...
  60. R Graham Barr; Fiscal Year: 2016
    ..Since the pulmonary arterioles and arteries in COPD respond to small increases in resistance at the level of the pulmonary capillaries by marked vasodilation,..
  61. Role of Nox4 in VSMC Migration
    MAZEN KHALIL KHALIL; Fiscal Year: 2011
    ..Different Noxes are present in different areas of the vasculature. In the large arteries, VSMCs contain Nox4 and Nox1...
  62. Jay D Humphrey; Fiscal Year: 2016
    ..Cardiovascular disease remains the leading cause of death and disability in the USA and stiffening of central arteries is now an unquestioned independent risk factor for many such diseases, including heart attack, stroke, and end-..
  63. Anti-fibrotic Coatings for Rapidly Exchangeable Bioprosthetic Heart Valve
    Ivan Vesely; Fiscal Year: 2010
    ..tissue of the aortic root;a vital part of the conduction system of the heart and the origin of the coronary arteries. VXI has successfully completed two Phase I projects...
  64. INHALATIONAL ANESTHETICS AND CORONARY VASOMOTION
    JOHN SILL; Fiscal Year: 1992
    ..The coronary vasculature consists of proximal epicardial coronary arteries that conduct blood from the aorta to myocardium and smaller distal intramyocardial arteries and arterioles that ..
  65. Prevention of neointimal thickening by Mst1
    Junichi Sadoshima; Fiscal Year: 2006
    ..mammalian sterile 20 like kinase 1 (Mst1) strongly prevents neointimal thickening in rat balloon-injured carotid arteries. Mst1 is a serine threonine kinase having versatile functions, including apoptosis and suppression of cell growth ..
  66. ENDOTHELIAL CELL DIVERSITY DURING FETAL DEVELOPMENT
    Eugene Levin; Fiscal Year: 2001
    ..marker, we have found a pattern of progressive and transitory tPA expression in endothelial cells of specific arteries. Expression of tPA starts with the dorsal aortae and is followed by the appearance of tPA in the endothelium of ..
  67. K Channel Plasticity and Regulation of Vasomotor Tone
    STEPHEN T O apos ROURKE; Fiscal Year: 2010
    ..uncovered a novel, and potentially important, mechanism that serves to limit the degree of nitrate tolerance in arteries. Namely, that coincident with tolerance to the nitrates, blood vessels adapt by developing a compensatory ..
  68. Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.
    Nancy L Kanagy; Fiscal Year: 2010
    ..New preliminary data demonstrate that mesenteric resistance arteries from these hypertensive IH rats have augmented vasoconstrictor responses to ET-1 but not to phenylephrine or KCI...
  69. MELATONIN AND CEREBRAL BLOOD FLOW AUTOREGULATION
    Mohan Viswanathan; Fiscal Year: 2000
    ..Recent studies demonstrate that high affinity melatonin receptors are also present in cerebral arteries and that melatonin is capable of causing constriction of these arteries...
  70. MECHANISMS OF HYPOXIC CEREBRAL VASODILATATION IN NEWBORN
    William Pearce; Fiscal Year: 1992
    ..be conducted using isolated segments of common carotid, basilar, posterior communicating, and rostral choroidal arteries taken from 3-7 day old lambs and adult sheep. Three main hypotheses will be examined...
  71. REACTIVE OXYGEN SPECIES AND VASCULAR O2 SENSING
    Michael S Wolin; Fiscal Year: 2010
    ..NADH levels control a baseline Nox oxidase-derived hydrogen peroxide-mediated relaxation of bovine pulmdnary arteries which is removed by hypoxia, resulting in contraction...
  72. Antithrombotic Gene Therapy
    Pierre Zoldhelyi; Fiscal Year: 2006
    ..work is that gene transfer of tissue factor pathway inhibitor (TFPI) to mechanically damaged atherosclerotic arteries and to vein grafts will suppress the development of chronic vascular stenosis and vein graft deterioration by ..
  73. IN VIVO ENDOTHELIAL INJURY AND DEPENDENT VASOMOTION
    James Chesebro; Fiscal Year: 1990
    The impairment of endothelial-dependent vascular relaxation (EDVR) in vivo in coronary arteries is probably related to the amount of endothelial injury induced in part by coronary risk factors and atherosclerosis in pigs and patients and ..