blood vessels

Summary

Summary: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).

Top Publications

  1. ncbi In vivo imaging of embryonic vascular development using transgenic zebrafish
    Nathan D Lawson
    Laboratory of Molecular Genetics, NICHD NIH, Building 6B, 6 Center Drive, Bethesda, MD 20892, USA
    Dev Biol 248:307-18. 2002
  2. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
  3. ncbi Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization
    George E Davis
    Department of Pathology, Texas A and M University System Health Science Center, College Station, USA
    Circ Res 97:1093-107. 2005
  4. ncbi Angiogenesis in health and disease
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Med 9:653-60. 2003
  5. doi Angiogenesis: a team effort coordinated by notch
    L K Phng
    London Research Institute, Cancer Research UK, United Kingdom
    Dev Cell 16:196-208. 2009
  6. ncbi Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels
    Dan E Berkowitz
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 108:2000-6. 2003
  7. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
  8. doi Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia
    Hiroyasu Kidoya
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Blood 115:3166-74. 2010
  9. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
  10. pmc Molecular control of endothelial cell behaviour during blood vessel morphogenesis
    Shane P Herbert
    Department of Biochemistry and Biophysics, Program in Developmental Biology, Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Nat Rev Mol Cell Biol 12:551-64. 2011

Detail Information

Publications351 found, 100 shown here

  1. ncbi In vivo imaging of embryonic vascular development using transgenic zebrafish
    Nathan D Lawson
    Laboratory of Molecular Genetics, NICHD NIH, Building 6B, 6 Center Drive, Bethesda, MD 20892, USA
    Dev Biol 248:307-18. 2002
    ..the zebrafish fli1 promoter is able to drive expression of enhanced green fluorescent protein (EGFP) in all blood vessels throughout embryogenesis...
  2. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
    ....
  3. ncbi Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization
    George E Davis
    Department of Pathology, Texas A and M University System Health Science Center, College Station, USA
    Circ Res 97:1093-107. 2005
    ..Thus, the composition of ECM and therefore the regulation of ECM degradation and remodeling serves pivotally in the control of lumen and tube formation and, finally, neovessel stability and maturation...
  4. ncbi Angiogenesis in health and disease
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Med 9:653-60. 2003
    b>Blood vessels constitute the first organ in the embryo and form the largest network in our body but, sadly, are also often deadly...
  5. doi Angiogenesis: a team effort coordinated by notch
    L K Phng
    London Research Institute, Cancer Research UK, United Kingdom
    Dev Cell 16:196-208. 2009
    ..Understanding when and how blood vessels respond to the combination of signals they encounter to achieve a balanced cellular response is a major ..
  6. ncbi Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels
    Dan E Berkowitz
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 108:2000-6. 2003
    ..We tested the hypotheses that arginase reciprocally regulates NOS by modulating L-arginine bioavailability and that arginase is upregulated in aging vasculature, contributing to depressed endothelial function...
  7. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
    The association of pericytes (PCs) to newly formed blood vessels has been suggested to regulate endothelial cell (EC) proliferation, survival, migration, differentiation, and vascular branching...
  8. doi Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia
    Hiroyasu Kidoya
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Blood 115:3166-74. 2010
    ..Apelin-deficient mice are viable but have narrow intersomitic vessels during embryogenesis and narrow blood vessels in the trachea and skin after birth...
  9. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
    ..types - endothelial cells and vascular smooth muscle cells/pericytes (vSMC/PC) - into many different types of blood vessels. Most, if not all, vessels begin as endothelial tubes that subsequently acquire a vSMC/PC coating...
  10. pmc Molecular control of endothelial cell behaviour during blood vessel morphogenesis
    Shane P Herbert
    Department of Biochemistry and Biophysics, Program in Developmental Biology, Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Nat Rev Mol Cell Biol 12:551-64. 2011
    The vertebrate vasculature forms an extensive branched network of blood vessels that supplies tissues with nutrients and oxygen...
  11. doi Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis
    Li Kun Phng
    Vascular Biology Laboratory, London Research Institute Cancer Research UK, London, UK
    Dev Cell 16:70-82. 2009
    ..In vivo, loss of Nrarp, Lef1, or endothelial Ctnnb1 causes vessel regression. We suggest that the balance between Notch and Wnt signaling determines whether to make or break new vessel connections...
  12. pmc Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels
    Christa Maes
    Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Dev Cell 19:329-44. 2010
    ..Throughout the translocation, some precursors were found to intimately associate with invading blood vessels, in pericyte-like fashion. A similar coinvasion occurs during endochondral healing of bone fractures...
  13. ncbi Molecular regulation of angiogenesis and lymphangiogenesis
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 8:464-78. 2007
    b>Blood vessels and lymphatic vessels form extensive networks that are essential for the transport of fluids, gases, macromolecules and cells within the large and complex bodies of vertebrates...
  14. doi Vascularization is the key challenge in tissue engineering
    Esther C Novosel
    University of Stuttgart, Institute for Interfacial Engineering, Nobelstrasse 12, Stuttgart, Germany
    Adv Drug Deliv Rev 63:300-11. 2011
    ..Advantages and pitfalls of the approaches to create vascularized tissues in vitro are outlined and feasible future strategies are discussed...
  15. pmc VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels
    Anna Cariboni
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Development 138:3723-33. 2011
    ..but not endothelial, NRP1 expression and that it occurs independently of KDR, the main VEGF receptor in blood vessels. Therefore, VEGF164 provides survival signals directly to developing GnRH neurons, independently of its role ..
  16. pmc Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos
    Mercedes Montero-Balaguer
    FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 4:e5772. 2009
    ..However, the mechanism of action of VE-cadherin is complex and, in the mouse embryo, it is difficult to define the specific steps of vascular development in which this protein is involved...
  17. pmc Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
    Sunyoung Lee
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles 90095, USA
    J Cell Biol 169:681-91. 2005
    ..Our findings support the view that matrix-bound VEGF and nontethered VEGF provide different signaling outcomes. These findings reveal a novel aspect in the regulation of extracellular VEGF that holds significance for vascular patterning...
  18. ncbi Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis
    Gianfranco Bazzoni
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Physiol Rev 84:869-901. 2004
    ..Finally, we analyze in vivo studies and highlight information that specifically relates to the role of junctions in vascular endothelial cells...
  19. ncbi Angiogenesis in life, disease and medicine
    Peter Carmeliet
    Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology VIB, B 3000 Leuven, Belgium
    Nature 438:932-6. 2005
    The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders...
  20. ncbi Cellular and molecular analyses of vascular tube and lumen formation in zebrafish
    Suk Won Jin
    Department of Biochemistry and Biophysics and Cardiovascular Research Institute, Program in Developmental Biology, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
    Development 132:5199-209. 2005
    ..These studies provide the tools and a cellular framework for the investigation of mutations affecting vasculogenesis in zebrafish...
  21. ncbi The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
    Xiaowei Lu
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nature 432:179-86. 2004
    b>Blood vessels and nerves are complex, branched structures that share a high degree of anatomical similarity. Guidance of vessels and nerves has to be exquisitely regulated to ensure proper wiring of both systems...
  22. pmc Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Pathol 162:1951-60. 2003
    ..In contrast, no differences in the density of tumor-associated blood vessels were found...
  23. doi The role of the Angiopoietins in vascular morphogenesis
    Markus Thomas
    Joint Research Division Vascular Biology, Medical Faculty Mannheim CBTM, University of Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Angiogenesis 12:125-37. 2009
    ..The better mechanistic understanding of the Ang/Tie system is gradually paving the way toward the rationale exploitation of this vascular signaling system as a therapeutic target for neoplastic and non-neoplastic diseases...
  24. pmc Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation
    Amber N Stratman
    Department of Medical Pharmacology and Physiology, School of Medicine, Dalton Cardiovascular Center, University of Missouri, Columbia, MO 65212, USA
    Blood 114:5091-101. 2009
    ....
  25. ncbi Angiogenic network formation in the developing vertebrate trunk
    Sumio Isogai
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Development 130:5281-90. 2003
    ..of living Tg(fli1:EGFP)y1 zebrafish embryos to examine how a patterned, functional network of angiogenic blood vessels is generated in the early vertebrate trunk...
  26. doi The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
    Rui Benedito
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    Cell 137:1124-35. 2009
    ..In growing blood vessels, sprouting of endothelial tip cells is inhibited by Notch signaling, which is activated by binding of the ..
  27. ncbi Molecular regulation of vessel maturation
    Rakesh K Jain
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Med 9:685-93. 2003
    ..Normalization of the abnormal vasculature can facilitate drug delivery to tumors and formation of a mature vasculature can help realize the promise of therapeutic angiogenesis and tissue engineering...
  28. pmc Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels
    Hisamichi Naito
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    EMBO J 31:842-55. 2012
    ..However, EPCs are scattered throughout newly developed blood vessels and cannot be solely responsible for vascularization...
  29. pmc Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    Johannes Peter Stasch
    Institute of Cardiovascular Research, Bayer HealthCare, Wuppertal, Germany
    J Clin Invest 116:2552-61. 2006
    ..Importantly, in isolated cells, in blood vessels, and in vivo, BAY 58-2667 was more effective and potentiated under pathophysiological and oxidative stress ..
  30. pmc Notch signaling in the vasculature
    Thomas Gridley
    The Jackson Laboratory, Bar Harbor, ME, USA
    Curr Top Dev Biol 92:277-309. 2010
    ..This review summarizes recent studies that highlight the multiple roles the Notch signaling pathway plays during vascular development and physiology...
  31. pmc Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling
    Jason D Roh
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 107:4669-74. 2010
    ..These TEVGs transform into living blood vessels in vivo, with an endothelial cell (EC) lining invested by smooth muscle cells (SMCs); however, the process by ..
  32. ncbi Regulation of vascular morphogenesis by Notch signaling
    Cristina Roca
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 21:2511-24. 2007
    ..Recent findings highlight the Notch ligand Delta-like 4 as a key regulator of tumor angiogenesis and suggest that this protein might be a promising target for cancer therapy...
  33. pmc Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels
    Patrick Au
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Blood 111:1302-5. 2008
    ..blood-derived endothelial progenitor cells (EPCs) are attractive source of cells for use in engineering blood vessels. However, the durability and function of EPC-derived vessels implanted in vivo are unclear...
  34. ncbi Endothelial glycocalyx: sweet shield of blood vessels
    Jurgen W Van Teeffelen
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Trends Cardiovasc Med 17:101-5. 2007
    ..microscopic observations had shown that anionic polysaccharides were also presented by the inner surface of blood vessels but the length of these structures was considered to be small and their functional significance was unknown...
  35. ncbi Cellular abnormalities of blood vessels as targets in cancer
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Curr Opin Genet Dev 15:102-11. 2005
    Tumor blood vessels have multiple structural and functional abnormalities. They are unusually dynamic, and naturally undergo sprouting, proliferation, remodeling or regression...
  36. ncbi Requirement of vascular integrin alpha v beta 3 for angiogenesis
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 264:569-71. 1994
    ..Integrin alpha v beta 3 was expressed on blood vessels in human wound granulation tissue but not in normal skin, and it showed a fourfold increase in expression ..
  37. ncbi Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
    D J Dumont
    Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    Science 282:946-9. 1998
    ..5. Thus, VEGFR-3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels...
  38. pmc ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification
    Dongjun Lee
    National Research Laboratory, Department of Biological Science, KAIST, Daejeon, Korea
    Cell Stem Cell 2:497-507. 2008
    ..Collectively, we provide compelling evidence that ER71 functions downstream of BMP, Notch, and Wnt signals and regulates FLK1(+) mesoderm, blood, and vessel development...
  39. ncbi Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    J Holash
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 284:1994-8. 1999
    ....
  40. ncbi Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Nature 380:435-9. 1996
    ..Here we report that formation of blood vessels was abnormal, but not abolished, in heterozygous VEGF-deficient (VEGF+/-) embryos, generated by aggregation of ..
  41. ncbi Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels
    Beth L Roman
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 129:3009-19. 2002
    ..Movies available on-line..
  42. ncbi Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors
    K M Channon
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Physiol Pharmacol 53:515-24. 2002
    ..In human blood vessels, the NAD(P)H oxidase system is the principal source of superoxide, and is functionally related to clinical ..
  43. ncbi Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63. 2004
    ..During the normalization window, but not before or after it, VEGFR2 blockade increases pericyte coverage of brain tumor vessels via upregulation of Ang1 and degrades their pathologically thick basement membrane via MMP activation...
  44. pmc IP-10 induces dissociation of newly formed blood vessels
    Richard J Bodnar
    Pittsburgh Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA
    J Cell Sci 122:2064-77. 2009
    ..We demonstrate that activation of CXC chemokine receptor 3 (CXCR3) mediates the regression of newly formed blood vessels. We present evidence that CXCR3 is expressed on newly formed vessels in vivo and in vitro...
  45. doi Bronchial vascular remodelling in patients with COPD and its relationship with inhaled steroid treatment
    A Zanini
    Salvatore Maugeri Foundation, Division of Pneumology, IRCCS Rehabilitation Institute of Tradate, Italy
    Thorax 64:1019-24. 2009
    ..A study was undertaken to evaluate vascular remodelling, its relationship with inflammatory cells and treatment effects in the bronchial mucosa of patients with COPD...
  46. doi Lymphatic and blood vessels in basal and triple-negative breast cancers: characteristics and prognostic significance
    Rabab A A Mohammed
    Department of Clinical Oncology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Mod Pathol 24:774-85. 2011
    ..studies have examined their pathological and molecular profile, the vascular characteristics of lymphatic and blood vessels have not been examined...
  47. pmc Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
    Clare R Ozawa
    Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    J Clin Invest 113:516-27. 2004
    ..constitutive expression of VEGF for therapeutic angiogenesis may be limited by the growth of abnormal blood vessels and hemangiomas...
  48. ncbi Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases
    J P Montani
    Department of Medicine Division of Physiology, University of Fribourg, Switzerland
    Int J Obes Relat Metab Disord 28:S58-65. 2004
    ..is to explore the possible locations of ectopic fat in key target-organs of cardiovascular control (heart, blood vessels and kidneys) and to propose how ectopic fat storage can play a role in the pathogenesis of cardiovascular ..
  49. pmc In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels
    Hidekazu Sekine
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, TWIns, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Nat Commun 4:1399. 2013
    ..Here we report a technique to engineer cardiac tissues with perfusable blood vessels in vitro...
  50. pmc Isolating and defining cells to engineer human blood vessels
    P J Critser
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA
    Cell Prolif 44:15-21. 2011
    ..into which the cells should be embedded and delivered to accelerate and even pattern number and size of blood vessels formed, in vivo...
  51. pmc Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells
    Debanjan Chakroborty
    Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 108:20730-5. 2011
    Impaired blood flow in the tumor vascular bed caused by structurally and functionally abnormal blood vessels not only hinders the delivery of chemotherapeutic agents but also aggravates tumor hypoxia, making the tumor cells further ..
  52. pmc Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels
    Deepesh Pandey
    Vascular Biology Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    Am J Physiol Heart Circ Physiol 302:H1919-28. 2012
    ..The goal of this study was to determine whether Nox5-α, -β, -δ, -γ, and -ε (short) are expressed in human blood vessels and evaluate their respective functions...
  53. doi Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction
    Ping Gu
    Department of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR
    Rev Endocr Metab Disord 14:49-58. 2013
    There is a close anatomical and functional relationship between adipose tissue and blood vessels. The crosstalk between these two organs is vital to both metabolic and vascular homeostasis...
  54. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..The existence of these cells opens new opportunities for myocardial repair...
  55. ncbi A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis
    Shosei Yoshida
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Science 317:1722-6. 2007
    ..This is different from what is observed in Drosophila or Caenorhabditis elegans, which display developmentally specified niche structures within polarized gonads...
  56. ncbi Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities
    Mattias Bjarnegard
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 131:1847-57. 2004
    ..we show here that genetic ablation of Pdgfb in endothelial cells leads to impaired recruitment of pericytes to blood vessels. The endothelium-restricted Pdgfb knockout mutants also developed organ defects including cardiac, placental ..
  57. doi The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow
    Ivan B Lobov
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 6707, USA
    Blood 117:6728-37. 2011
    ..Modulation of VEGF-A and Dll4/Notch signaling produced distinct changes in blood vessel morphology and gene expression, indicating that these pathways can have largely independent functions in vascular remodeling...
  58. ncbi Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 120:813-9. 2007
    ..Increased vascularity and expression of vascular endothelial growth factor (VEGF) are recognized features of the asthmatic airway. The association of vascular remodeling with airway hyperresponsiveness (AHR) is unclear...
  59. ncbi Imaging of angiogenesis: from microscope to clinic
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, California 94143 0452, USA
    Nat Med 9:713-25. 2003
    ..Vascular imaging makes it possible to quantify the number and spacing of blood vessels, measure blood flow and vascular permeability, and analyze cellular and molecular abnormalities in blood ..
  60. ncbi The vascular niche and its basement membrane
    Ganka Nikolova
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D 01307 Dresden, Germany
    Trends Cell Biol 17:19-25. 2007
    ..We further propose that these cells require a vascular niche when they retain a high degree of plasticity...
  61. doi Vasculitis
    Carol A Langford
    Center for Vasculitis Care and Research, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH 44195, USA
    J Allergy Clin Immunol 125:S216-25. 2010
    ..Individual diseases predominantly affect blood vessels of a particular size, which influences their clinical manifestations and has been used in their classification...
  62. doi Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts
    Simon Walker-Samuel
    Cancer Research UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
    Int J Cancer 130:1284-93. 2012
    ....
  63. pmc Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA
    Radiat Res 174:331-40. 2010
    ..Further study of low fluence rate as a means to improve responses to PDT under conditions designed to predominantly damage vasculature is warranted...
  64. pmc Vascular permeability, vascular hyperpermeability and angiogenesis
    Janice A Nagy
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Angiogenesis 11:109-19. 2008
    ..Further work will be required to elucidate the signaling pathways by which each of these molecules, and others likely to be discovered, mediate the different types of vascular permeability...
  65. pmc Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation
    Timothy P Fitzgibbons
    Program in Molecular Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Am J Physiol Heart Circ Physiol 301:H1425-37. 2011
    ....
  66. doi Alterations in perivascular adipose tissue structure and function in hypertension
    Chao Lu
    Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
    Eur J Pharmacol 656:68-73. 2011
    ..The functional impairment observed in SHR PVAT may be related to changes in adipocyte composition but not to reduced PVAT mass in SHR...
  67. pmc Mechanotransduction in vascular physiology and atherogenesis
    Cornelia Hahn
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Mol Cell Biol 10:53-62. 2009
    ....
  68. pmc The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells
    Julia Testori
    Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 117:2735-44. 2011
    ..These data suggest that HLX may function to balance attractive with repulsive vessel guidance by up-regulating UNC5B and to down-modulate sprouting under normoxic conditions...
  69. ncbi In vivo visualization of bonghan ducts inside blood vessels of mice by using an Alcian blue staining method
    Jung Sun Yoo
    Frontier Physics Research Division and Biomedical Physics Laboratory, Department of Physics and Astronomy, Seoul National University, Seoul, Korea
    Indian J Exp Biol 46:336-9. 2008
    An in vivo method using Alcian blue (AB) was developed for visualizing floating threadlike tissues inside blood vessels of mice...
  70. doi Cranial vasculature in zebrafish forms by angioblast cluster-derived angiogenesis
    Kira Proulx
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Dev Biol 348:34-46. 2010
    ..Such angioblast cluster-derived angiogenesis is likely to be involved during vasculature formation in other vertebrate systems as well...
  71. pmc Regulation of vascular integrity
    Masahiro Murakami
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Mol Med (Berl) 87:571-82. 2009
    The integrity of blood vessels is critical to vascular homeostasis. Maintenance of vascular integrity has been conventionally regarded as a passive process that is largely dependent on continuous blood flow...
  72. pmc VE-PTP controls blood vessel development by balancing Tie-2 activity
    Mark Winderlich
    Max Planck Institute of Molecular Biomedicine, D 48149 Munster, Germany
    J Cell Biol 185:657-71. 2009
    ..We conclude that VE-PTP is required to balance Tie-2 activity and endothelial cell proliferation, thereby controlling blood vessel development and vessel size...
  73. doi Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1
    Coral Ann B Lewis
    School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada
    Glia 57:1410-9. 2009
    ....
  74. doi Vascular imaging in small rodents using micro-CT
    Sebastian J Schambach
    Department of Neuroradiology, University of Heidelberg, Mannheim, Germany
    Methods 50:26-35. 2010
    ..Our setup in mice is at isotropic resolutions up to 16 microm with scanning times less than 1 min. The described protocol also addresses some of the technical challenges associated with the imaging of vascular structures in mice models...
  75. pmc Tissue-engineered blood vessels in pediatric cardiac surgery
    Toshiharu Shinoka
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8039, USA
    Yale J Biol Med 81:161-6. 2008
    ..In this review article, we provide an overview of our work developing "tissue-engineered blood vessels" created by utilizing autologous mononuclear bone marrow cells.
  76. ncbi Vascular wall-resident stem cells
    Diana Klein
    Institute of Anatomy, University Hospital Essen, Essen, Germany
    Histol Histopathol 25:681-9. 2010
    ..g. whether a VW-SC is able to give rise to a complete hierarchy of vascular progenitors still remains to be studied. This review will provide a survey about the VW-SCs and their potential impact in vascular biology...
  77. pmc Neuropilin ligands in vascular and neuronal patterning
    Alessandro Fantin
    UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Biochem Soc Trans 37:1228-32. 2009
    b>Blood vessels and neurons share guidance cues and cell-surface receptors to control their behaviour during embryogenesis...
  78. ncbi Thoracic aortas from multiorgan donors are suitable for obtaining resident angiogenic mesenchymal stromal cells
    Gianandrea Pasquinelli
    Clinical Pathology, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    Stem Cells 25:1627-34. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  79. ncbi Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    P C Maisonpierre
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 277:55-60. 1997
    ..Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system...
  80. ncbi Antiangiogenic agents are effective inhibitors of endometriosis
    M Louise Hull
    Department of Pathology, Reproductive Molecular Research Group, Cambridge, United Kingdom CB2 1QP
    J Clin Endocrinol Metab 88:2889-99. 2003
    ..These findings suggest that antiangiogenic agents may provide a novel therapeutic approach for the treatment of endometriosis...
  81. pmc Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse
    Feng Ju Huang
    Sanford Burnham Medical Research Institute, Cancer Center, La Jolla, CA 92037, USA
    Dev Biol 344:1035-46. 2010
    ..crosstalk between endothelial cells and pericytes is required for formation and maintenance of functional blood vessels. When the NG2 proteoglycan is absent from pericyte surfaces, vascularization of syngeneic tumors growing in ..
  82. doi Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy
    Vincent T Marchesi
    Department of Pathology, Boyer Center for Molecular Medicine, Yale University, 295 Congress Ave, P O Box 9812, New Haven, CT 06536 0812, USA
    FASEB J 25:5-13. 2011
    ..the possibility that the initial pathological changes involve oxidative-induced inflammatory damage to small blood vessels. The resulting ischemia activates amyloid-processing enzymes and other proinflammatory factors that eventually ..
  83. ncbi Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage
    Fiorentina Roviezzo
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras, Greece 26504
    J Pharmacol Exp Ther 314:738-44. 2005
    ..It is widely accepted that Ang-1 promotes the structural integrity of blood vessels and exhibits anti-inflammatory properties...
  84. ncbi Extra-cellular matrix in vascular networks
    George Bou-Gharios
    Renal Medicine, Imperial College London, Hammersmith Campus, London, W12 ONN, UK
    Cell Prolif 37:207-20. 2004
    The vascular network is a series of linked conduits of blood vessels composed of the endothelium, a monolayer of cells that adorn the vessel lumen and surrounding layer(s) of mesenchymal cells (vascular smooth muscle, pericytes and ..
  85. pmc The netrin receptor UNC5B promotes angiogenesis in specific vascular beds
    Sutip Navankasattusas
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 135:659-67. 2008
    There is emerging evidence that the canonical neural guidance factor netrin can also direct the growth of blood vessels. We deleted the gene encoding UNC5B, a receptor for the netrin family of guidance molecules, specifically within the ..
  86. ncbi Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    Jeffrey B Wyckoff
    Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:2649-56. 2007
    ..These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors...
  87. ncbi Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:62-6. 1995
    ..Yolk-sac blood islands were absent at 7.5 days, organized blood vessels could not be observed in the embryo or yolk sac at any stage, and haematopoietic progenitors were severely ..
  88. ncbi Angiogenesis and tumor metastasis
    B R Zetter
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Med 49:407-24. 1998
    Angiogenesis, the recruitment of new blood vessels, is an essential component of the metastatic pathway. These vessels provide the principal route by which tumor cells exit the primary tumor site and enter the circulation...
  89. ncbi Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF-family gene expression
    William W L Choi
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30033, USA
    Mod Pathol 18:143-52. 2005
    ..0558 by microscopy). Immunohistochemical VEGF signal in peritumoral blood vessels correlated with image cytometric CD31 and D2-40 microvessel density (P=0.022 and 0...
  90. ncbi Pericytes and vascular stability
    Desiree von Tell
    Vascular Biology Laboratory, Division of Matrix Biology, Department of Medical, Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Exp Cell Res 312:623-9. 2006
    ..Several ligand-receptor systems have been implicated in endothelial-pericyte interactions. Here, we discuss the role of some of these signaling systems in the regulation of vascular stability...
  91. pmc Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis
    Hiroyasu Kidoya
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    EMBO J 27:522-34. 2008
    b>Blood vessels change their caliber to adapt to the demands of tissues or organs for oxygen and nutrients. This event is mainly organized at the capillary level and requires a size-sensing mechanism...
  92. pmc Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease: a cross-sectional study
    Amir Soltani
    Respiratory Research Group, Menzies Research Institute, University of Tasmania, 17 Liverpool St, Hobart, 7000, Australia
    Respir Res 11:105. 2010
    ..We conducted an initial pilot study comparing BB from COPD patients with nonsmoking controls. This pilot study suggested the presence of reticular basement membrane (Rbm) fragmentation and altered vessel distribution in COPD...
  93. pmc Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development
    Arjan van der Flier
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 137:2439-49. 2010
    ..These integrins on other cells, and/or other integrins on endothelial cells, might contribute to fibronectin assembly and vascular development...
  94. pmc Notch pathway modulation on bone marrow-derived vascular precursor cells regulates their angiogenic and wound healing potential
    Francisco Caiado
    Angiogenesis Laboratory, CIPM, Portuguese Institute of Oncology, Lisbon, Portugal
    PLoS ONE 3:e3752. 2008
    ..cells at sites of vascular remodelling/recovery, and their contribution towards the formation of new blood vessels are still undisclosed...
  95. ncbi Intussusceptive angiogenesis: its role in embryonic vascular network formation
    V Djonov
    Institute of Anatomy, University of Berne, Switzerland
    Circ Res 86:286-92. 2000
    ....
  96. pmc Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
    Rickmer Braren
    The Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery, Howard Hughes Medical Institute, San Francisco, CA 94143, USA
    J Cell Biol 172:151-62. 2006
    ..This study reveals that FAK is crucial for vascular morphogenesis and the regulation of EC survival and morphology...
  97. pmc Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis
    Philip M Bauer
    Department of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 102:204-9. 2005
    ..These data strongly support the idea that, in vivo, Cav-1 may modulate signaling pathways independent of its essential role in caveolae biogenesis...
  98. ncbi Overexpression of semicarbazide sensitive amine oxidase in the cerebral blood vessels in patients with Alzheimer's disease and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    I Ferrer
    Institut de Neuropatologia, Hospital Princeps d Espanya, L Hospitalet de Llobregat 08907, Barcelona, Spain
    Neurosci Lett 321:21-4. 2002
    ..deamination of primary aromatic and aliphatic amines, and, in the brain, it is selectively expressed in blood vessels. SSAO expression is examined, by immunohistochemistry with a purified polyclonal antibody to SSAO from bovine ..
  99. pmc Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels
    Beverly L Falcon
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Am J Pathol 175:2159-70. 2009
    ..The Ang2 inhibitor decreased the overall abundance of tumor blood vessels by reducing tumor growth and keeping vascular density constant...
  100. ncbi Structural and functional alteration of blood vessels caused by cigarette smoking: an overview of molecular mechanisms
    Mohammad M Rahman
    Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, University of British Columbia, Vancouver, B C, V6T 1Z3, Canada
    Curr Vasc Pharmacol 5:276-92. 2007
    ....
  101. pmc FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish
    Jayoung Choi
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 304:735-44. 2007
    ..Taken together, our data provide the first evidence that flk1 is a direct target of FoxH1 and that FoxH1 is involved in vessel formation in zebrafish...

Research Grants78

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..It causes the blood vessels in the retina at the back of the eye to leak, causing swelling...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..It causes the blood vessels in the retina at the back of the eye to leak, causing swelling...
  3. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..protein C is now established as a protein that will dampen blood clotting, and exert a protective effect on blood vessels, thus serving as a feedback mechanism to down modulate thrombin's clotting and inflammatory functions...
  4. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..neurons called the C1 neurons that innervate the spinal cord and regulate sympathetic tone to the heart and blood vessels. The contribution of the C1 neurons to blood pressure stabilization, including during hypoxia, is well ..
  5. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..found that damaging a particular gene in mice results in reduced body fat, diabetic symptoms, abnormal major blood vessels of the heart, and marked inability to perform exercise...
  6. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..production and deposition of abnormal immunoglobulin light chain proteins in various organs such as the heart, blood vessels, kidneys, gut and liver. The cause of injury to blood vessels by amyloid light chains is unknown...
  7. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    ..Retinopathy (DR) and Macular Degeneration (AMD), blindness results from the pathologic development of new blood vessels which are incomplete, weak and porous...
  8. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..HEALTH RELEVANCE: Our research aim is to understand why atherosclerosis, also known as the "hardening of blood vessels," occurs in cardiovascular system...
  9. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..the inflammatory process, which is central to so many pathophysiological conditions that affect the heart and blood vessels (e.g., heart attacks and strokes), as well as other organs and tissues of the body...
  10. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..There are two primary control points. Blood vessels near the brain surface maintain blood pressure in a relatively constant range according to the physiological ..
  11. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..SJIA)] that afflict adults and children, as well as organ systems including joints, skin, blood elements, and blood vessels, and will both test efficacy of therapy and develop tests to characterize the mechanisms of action of these ..
  12. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Project Narrative Anesthetic gases are known to protect blood vessels and organs such as the heart, from injury during periods of low oxygen stress...
  13. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..Juvenile dermatomyositis (JDM) is an autoimmune disease of children, in which there is damage to the small blood vessels;chronic inflammation is associated with persistent rash, loss of range of motion, deposits of calcifications ..
  14. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..by negatively affecting nitric oxide synthases (NOS) and production of nitric oxide (NO), and NOS activity in blood vessels can be restored by statins. NO preserves vascular endothelial function in part by inhibiting angiotensin II...
  15. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Angiogenesis, the development of new blood vessels from existing vasculature, is a key event in many physiological processes, like organ growth and development, ..
  16. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2013
    ..the exciting finding that these mice are hypertensive and exhibit abnormality in the vascular tone of large blood vessels. In SA1, we will elucidate the molecular mechanism by which the BMPRII(TD)-FHL2 pathway modulates VSMC gene ..
  17. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..tomography system for regenerative medicine and to demonstrate its utility in assessing the bioengineered blood vessels at the pre- and post-implantation stages...
  18. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    ..approach has been to identify drugs that inhibit tumor angiogenesis, the process by which tumors attract blood vessels that bring in the nutrients needed for tumor growth...
  19. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..Oxidation changes "good cholesterol" into "bad cholesterol," which can no longer clean up blood vessels and airways...
  20. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..neutrophils and CD4+ (helper) and CD8+ (cytotoxic/suppressor) lymphocytes, as well as growth and dilation of blood vessels in the papillary dermis with CD4+ lymphocytes...
  21. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Development and remodeling of retinal blood vessels occurs through the complex and still poorly understood processes of vasculogenesis and angiogenesis...
  22. Tumor Cell Arrest and Adhesion in the Microcirculation
    Bingmei M Fu; Fiscal Year: 2013
    ..For example, breast cancer cells preferentially arrest in the small blood vessels of the lungs, liver, brain and bones...
  23. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..govern their ability to infect and kill humans, and why patients with AIDS develop diseases of the heart and blood vessels prematurely...
  24. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..because EVT ultimately become the invasive trophoblast (TR) cells of human placenta that penetrate maternal blood vessels and enhance blood flow...
  25. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012
    ..regulates Eos activation and potentially its adhesive function leading to increased trafficking of Eos in blood vessels and recruitment to inflamed lungs...
  26. Enhance Production of Functional Recombinant Human Protein C Variant In Mammalian
    Nienwen Chow; Fiscal Year: 2010
    ..Recent findings indicated that the compromised blood vessels in the ALS-affected spinal cord and brain areas may play an important role in the disease progression...
  27. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The healing of tissues after surgery or trauma is critical for long-term survival. The proposed work will study novel mechanisms by which blood vessels grow in response to tissue injury.
  28. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda M Graham; Fiscal Year: 2013
    ..We will investigate how oxidized lipids block the movement of endothelial cells (cells that normally line blood vessels) into an area of injury or onto a bypass graft...
  29. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..upper aerodigestive tract in speech and swallowing and due to the concentration of cranial nerves and major blood vessels in the neck, standard therapeutic modalities frequently result in unacceptable morbidity including speech and ..
  30. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
    ..overwhelming cause of severe vision loss in AMD is choroidal neovascularization (CNV), the growth of abnormal blood vessels into the retina...
  31. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ..To invade joints and other host tissue, the cells must adhere to the endothelium of blood vessels in target organs and penetrate through them. The unique motility and morphology of B...
  32. Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary Dysplasia
    Marlowe Eldridge; Fiscal Year: 2013
    ..the airways and pulmonary vasculature, leading to a decrease in the air exchanging units of the lung and fewer blood vessels that can participate in exchanging CO2 and O2...
  33. Examination of the Final Stages of Platelet Production
    JONATHAN NOAH THON; Fiscal Year: 2013
    ..MKs release long branched extensions called proPLTs into sinusoidal blood vessels that undergo repeated abcissions to yield circulating PLTs...
  34. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2012
    ..These mechanisms are explored in 3 Specific Aims using intact animals, blood vessels and cells with VSMC- or EC-specific, induced deletions of ER1 or ER2 in studies of the (SA1) role of vascular ..
  35. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..loss of capillaries with resulting ischemia, and, in the final stage of DR, the growth of abnormal retinal blood vessels (pathological retinal neovascularization) known as proliferative diabetic retinopathy (PDR)...
  36. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Pulmonary hypertension is a severe disease caused by an increase in pressure in the blood vessels that carry blood from the right side of the heart to the lungs...
  37. Mechanisms of endothelial barrier phenotypes in sickle cell disease
    SOLOMON FIIFI OFORI-ACQUAH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Endothelium forms a thin lining inside blood vessels that acts a barrier to control the response of the vasculature to inflammatory agonists...
  38. Neprilysin and Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
    EDWARD CHARLES DEMPSEY; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Project Narrative: Pulmonary hypertension, or high pressure in the lung blood vessels, is often caused by exposure to cigarette smoke and low oxygen levels (hypoxia);it is a major clinical problem ..
  39. Mechanism and therapy for arteriovenous malformation
    Suk Paul Oh; Fiscal Year: 2013
    ..noninvasive multiphoton fluorescence microscopy will be employed to capture 3-dimensional time lapse images blood vessels at subcellular level during AVM formation...
  40. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..through production of specific, estrogen-regulated enzymes that inhibit inflammatory cells from entering into blood vessels. This proposal may improve the application of anti-atherosclerosis agents and lead to development of new ..
  41. THE ROLE OF A-BETA SPECIES IN VASCULAR SMOOTH MUSCLE CELL AND CEREBRAL ARTERIOLE
    Gregory J Zipfel; Fiscal Year: 2013
    ..First, cerebral blood flow (CBF) is reduced in early stages of AD, and the reactivity of cerebral blood vessels is impaired - both of which have been linked to the vasoactive properties of A[unreadable]...
  42. Mechanisms mediating hematopoietic stem and progenitor cell trafficking
    Paul S Frenette; Fiscal Year: 2013
    ..found that these Nestin+ cells are anatomically and functionally associated with CD150+ CD48- Lin- HSCs near blood vessels of the BM...
  43. Endothelial Cell Dysregulation in Neovascular AMD
    Mark E Kleinman; Fiscal Year: 2013
    ..overwhelming cause of severe vision loss in AMD is choroidal neovascularization (CNV), the growth of abnormal blood vessels beneath the retina...
  44. TNF-Mediated Tumor Promotion: The Role of Vascular Leukocytes
    Pampee P Young; Fiscal Year: 2011
    ..biphenotypic cells represent a subpopulation of myeloid cells that are promote tumor growth and blood vessels. Using tumors that express slightly higher levels of TNF, we have strong evidence that at least one important ..
  45. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
    ..HEALTH RELEVANCE: After various forms of injury, the inner ear degenerates and inflammatory cells exit the blood vessels and enter the cochlea...
  46. Estrogen, Aging and Vascular Inflammation
    Anne A Knowlton; Fiscal Year: 2013
    ..set of molecules whose synthesis in the body may vary over time, in modulating inflammation and changes in the blood vessels with aging. The research investigates links between changes in estrogen and EETs...
  47. Plasminogen activators and NMDA after brain injury
    William M Armstead; Fiscal Year: 2012
    ..The term neurovascular unit (NVU) focuses attention on the interactions between cerebral blood vessels and neurons. The tPA treatment paradox could relate to vasodilation...
  48. BIOENGINEERING DESIGN OF ARTIFICIAL BLOOD
    Marcos Intaglietta; Fiscal Year: 2011
    ..use the awake hamster window chamber model, with direct measurements of O2 and NO levels, flow and diameter in blood vessels and functional capillary density...
  49. Regulatory targets and pathogenic mechanisms of anthrax edema factor
    Jin Mo Park; Fiscal Year: 2011
    ..known to increase vascular permeability, thereby causing edema, and also promote the growth of lymphatic and blood vessels. Based on these findings, we propose that EF may play a role in accelerating the migration of B...
  50. Harness Germinal Matrix Hemorrhage
    John H Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Germinal matrix hemorrhage (GMH) is defined as the rupture of immature blood vessels within the subependymal brain tissue. Occurring in approximately 3...
  51. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George L King; Fiscal Year: 2013
    ..explanations and potential interventions, such as the use of inhibitor of an enzyme, PKC, that can improve insulin's effect on the heart and the blood vessels, and decrease the risk of cardiovascular deaths in diabetic patients.
  52. Inhibition of angiogenesis by thrombospondin-1 (A2)
    JOHN W LAWLER; Fiscal Year: 2012
    ..The proposed research is designed to develop new strategies for inhibiting tumor growth by destroying the blood vessels that supply oxygen and nutrients to them...
  53. Mechanisms of Sensitization in High Risk Corneal Grafts
    Reza Dana; Fiscal Year: 2013
    ..to pursue four specific aims: In Aim 1, we will investigate the precise and distinct contributions of corneal blood vessels and lymphatics in mediating cell trafficking, and the function of pro-lymphangiogenic mediators, VEGF-C, VEGF-..
  54. The Forkhead Transcription Factor, FOXO1, and its Role in Pituitary Gland Develop
    BUFFY SUE ELLSWORTH; Fiscal Year: 2010
    ..The forkhead transcription factor, FOXO1, is essential for the normal development and function of muscle, blood vessels, and pancreas...
  55. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Angiogenesis, the formation of new blood vessels from preexisting capillaries, occurs during development and in many reparative processes in adults, such as ..
  56. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..In this proposal, we seek to non-invasively image atherosclerosis in blood vessels using a retinal imaging system...
  57. Insulin action in human cardiac and skeletal muscle microvasculature
    Zhenqi Liu; Fiscal Year: 2013
    ..We and others have recently shown that insulin resistance is present in the small blood vessels in heart and skeletal muscle...
  58. Regulatory Mechanisms of Oxidative Stress in Cardiac Angiogenesis Postinfarction
    Yao Sun; Fiscal Year: 2013
    ..In the infarcted myocardium, loss of contractile myocardium and blood vessels is induced by MI...
  59. Role of the zinc finger transcription factor ZBP89 in blood &vascular developmen
    M Amin Arnaout; Fiscal Year: 2013
    ..hematopoietic stem cells (HSCs) that in turn derive from hemangioblasts, common precursors of blood and blood vessels. Extensive studies have identified key transcription factors, such as the basic helix loop helix (bLH) SCL/..
  60. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2013
    ..functional studies in the kidney and vessels to test the hypothesis that ADMA mediates the effects of ROS on blood vessels and proximal tubular transport which could lead to new targets for intervention to prevent progressive ..
  61. C MYC--TRANSCRIPTION AND APOPTOSIS
    Chi V Dang; Fiscal Year: 2011
    ..We have shown that the hypoxia inducible factor, HIF that is required for tumor to recruit new blood vessels and to adapt to low oxygen tension, is essential for the cancer-inducing ability of MYC and plan to determine ..
  62. Histone deacetylase 7 and its interacting proteins in endothelial cells
    Hung Ying Kao; Fiscal Year: 2013
    ..dissect the roles of PML in TNF1-mediated adhesion, migration, proliferation, apoptosis, and remodeling of blood vessels using in vitro and in vivo approaches...
  63. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2013
    ..We propose to develop agents that can report on areas of instability in blood vessels and detoxify some of the reactive molecules that cause instability, which has implications in preventing heart ..
  64. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..Either direct incorporation into blood vessels in the area of ischemia or paracrine expression of growth promoting factors could enhance the observed repair...
  65. Lymphangiogenesis and Angiogenesis in Airway Inflammation
    Donald McDonald; Fiscal Year: 2009
    ..The overall hypothesis is that abnormalities in mucosal lymphatics and blood vessels contribute in multiple ways to the pathophysiology of airway inflammation and can be exploited as therapeutic ..
  66. K Channel Plasticity and Regulation of Vasomotor Tone
    STEPHEN T O apos ROURKE; Fiscal Year: 2010
    ..Namely, that coincident with tolerance to the nitrates, blood vessels adapt by developing a compensatory relaxation pathway...
  67. Novel Adeno-Associated Viral Therapy for Wet Age-Related Macular Degeneration
    James M Wilson; Fiscal Year: 2012
    ..The oxygen supply to the macula is disrupted and the body responds by growing new, abnormal blood vessels. These begin to grow through the breaks of the membrane behind the retina towards the macula, often raising ..
  68. Novel Reagents to Bypass Limitations of Existing Coagulation Assays
    Stephen Burgess; Fiscal Year: 2009
    ..Blood coagulation protects the integrity of damaged blood vessels and is localized specifically to cells at a site of injury by exposure of a specific type of lipid, ..
  69. Nox Isoforms and Vascular Cell Phenotype
    John Keaney; Fiscal Year: 2009
    ..Aged blood vessels are characterized by reduced control of antioxidant enzymes, an increased flux of reactive oxygen species, and ..
  70. CORONARY BLOOD VESSELS AND HEART DISEASE
    Thomas Sato; Fiscal Year: 2004
    The long-term objectives are to understand how the morphogenesis and the physiological functions of coronary blood vessels are controlled at the molecular level, and to contribute to the translation of our findings into novel and ..
  71. Treatment of Retinal Vascular Leakage Using Angiostatin
    Gennadiy Moiseyev; Fiscal Year: 2005
    ..barrier (BRB) and subsequent retinal vascular hyper-permeability or leakage of macromolecules from the blood vessels into the retina are believed to be the major causes of DME...
  72. Accelerated Repair of Vascular Injury in Diabetes by TGF-beta Modified Stem Cells
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..CD34+ stem cells can give rise to endothelial progenitor cells (EPC), which have been shown to repair damaged blood vessels. CXCR4 are homing receptors expressed on EPC...
  73. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2005
    ..Recently, we have demonstrated that the hair follicle gives rise to blood vessels in vivo with the blood vessels apparently originating from the hair-follicle stem cells (Amoh, Y., et al...
  74. Targeting Caveolae in Breast Tumors
    Jan Schnitzer; Fiscal Year: 2006
    ..The growth of blood vessels in tumors is essential for their growth and metastasis...
  75. Cytomegalovirus infection of blood vessels
    Fenyong Liu; Fiscal Year: 2005
    ..from developing CMV-associated vascular diseases requires eliminating HCMV infection from the blood vessels and blocking viral replication in these tissues...
  76. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..We have demonstrated that the hair follicle gives rise to blood vessels in vivo with the blood vessels originating from the hair-follicle bulge cells (13)...
  77. SKELETAL MUSCLE MICROVASCULAR PERFUSION IN HYPERTENSION
    Sarah Gray; Fiscal Year: 1999
    ..Hypertension may have a significant effect on muscle regeneration, particularly on the regeneration of muscle blood vessels and the restoration of normal vascular control mechanisms...
  78. Mechanisms of Early Kidney Development
    TERI MAUCH; Fiscal Year: 2007
    ..Time-lapse videomicroscopy will follow the development of PM, IM angioblasts, and blood vessels. We will determine whether ectopically induced somites and pronephroi form in association with ectopic blood ..