cardiovascular system

Summary

Summary: The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.

Top Publications

  1. ncbi Biological properties of baicalein in cardiovascular system
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Curr Drug Targets Cardiovasc Haematol Disord 5:177-84. 2005
  2. ncbi Aldosterone: effects on the kidney and cardiovascular system
    Marie Briet
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
    Nat Rev Nephrol 6:261-73. 2010
  3. ncbi MicroRNAs in the cardiovascular system
    Mingyue Han
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Curr Opin Cardiol 26:181-9. 2011
  4. ncbi Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system
    B Delorme
    Laboratoire de Genetique et Physiologie du Developpement, UMR C9943, Institut de Biologie du Developpement de Marseille, France
    Circ Res 81:423-37. 1997
  5. pmc CaMKII in the cardiovascular system: sensing redox states
    Jeffrey R Erickson
    Department of Pharmacology, University of California at Davis, Davis, California 95616, USA
    Physiol Rev 91:889-915. 2011
  6. ncbi Prolactin-releasing peptide regulates the cardiovascular system via corticotrophin-releasing hormone
    T Yamada
    Department of Regulatory Biology, Graduate School of Science and Engineering, Saitama University, Sakura ku, Saitama, Japan
    J Neuroendocrinol 21:586-93. 2009
  7. ncbi Invited review: aging and the cardiovascular system
    Alberto U Ferrari
    Dipartimento di Medicina, Universita di Milano Bicocca, Milano, Italy
    J Appl Physiol (1985) 95:2591-7. 2003
  8. ncbi Neural influences on cardiovascular variability: possibilities and pitfalls
    Simon C Malpas
    Circulatory Control Laboratory, Department of Physiology, University of Auckland, Auckland, New Zealand
    Am J Physiol Heart Circ Physiol 282:H6-20. 2002
  9. ncbi Effects of thyroid hormone on the cardiovascular system
    Serafino Fazio
    Department of Clinical Medicine and Cardiovascular Sciences, University of Naples Federico II School of Medicine, 80131, Naples, Italy
    Recent Prog Horm Res 59:31-50. 2004
  10. ncbi Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system
    Donald H Maurice
    Heart and Stroke Foundation of Ontario Career Investigator, Department of Pharmacology and Toxicology, Botterell Hall, A215, Queen s University, Kingston, Ontario, Canada, K7L 3N6
    Mol Pharmacol 64:533-46. 2003

Detail Information

Publications323 found, 100 shown here

  1. ncbi Biological properties of baicalein in cardiovascular system
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Curr Drug Targets Cardiovasc Haematol Disord 5:177-84. 2005
    ..The pharmacological findings have highlighted the therapeutic potentials of using plant-derived baicalein and its analogs for the treatment of arteriosclerosis and hypertension...
  2. ncbi Aldosterone: effects on the kidney and cardiovascular system
    Marie Briet
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
    Nat Rev Nephrol 6:261-73. 2010
    ..In the cardiovascular system, aldosterone has specific hypertrophic and fibrotic effects and can alter endothelial function...
  3. ncbi MicroRNAs in the cardiovascular system
    Mingyue Han
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Curr Opin Cardiol 26:181-9. 2011
    ..In addition, they are potentially highly effective therapeutic tools. In this review, we will summarize the recent advancements in the field...
  4. ncbi Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system
    B Delorme
    Laboratoire de Genetique et Physiologie du Developpement, UMR C9943, Institut de Biologie du Developpement de Marseille, France
    Circ Res 81:423-37. 1997
    ..In addition, comparison of Cx40 and Cx43 distribution at the above developmental stages has shown that these Cxs have overlapping (left ventricle) or complementary (atrial tissue and right ventricle) expression patterns...
  5. pmc CaMKII in the cardiovascular system: sensing redox states
    Jeffrey R Erickson
    Department of Pharmacology, University of California at Davis, Davis, California 95616, USA
    Physiol Rev 91:889-915. 2011
    ..protein kinase II (CaMKII) is now recognized to play a central role in pathological events in the cardiovascular system. CaMKII has diverse downstream targets that promote vascular disease, heart failure, and arrhythmias, so ..
  6. ncbi Prolactin-releasing peptide regulates the cardiovascular system via corticotrophin-releasing hormone
    T Yamada
    Department of Regulatory Biology, Graduate School of Science and Engineering, Saitama University, Sakura ku, Saitama, Japan
    J Neuroendocrinol 21:586-93. 2009
    ..Thus, we conclude that PrRP stimulated CRH neurones in the PVN and that CRH might regulate the cardiovascular system via the sympathetic nervous system.
  7. ncbi Invited review: aging and the cardiovascular system
    Alberto U Ferrari
    Dipartimento di Medicina, Universita di Milano Bicocca, Milano, Italy
    J Appl Physiol (1985) 95:2591-7. 2003
    ..Reflexes arising from cardiopulmonary vagal afferents are also blunted in aged individuals. The cardiovascular and reflex changes brought about by aging may have significant implications for circulatory homeostasis in health and disease...
  8. ncbi Neural influences on cardiovascular variability: possibilities and pitfalls
    Simon C Malpas
    Circulatory Control Laboratory, Department of Physiology, University of Auckland, Auckland, New Zealand
    Am J Physiol Heart Circ Physiol 282:H6-20. 2002
    Altered variability in the cardiovascular system is associated with a range of cardiovascular diseases and increased mortality...
  9. ncbi Effects of thyroid hormone on the cardiovascular system
    Serafino Fazio
    Department of Clinical Medicine and Cardiovascular Sciences, University of Naples Federico II School of Medicine, 80131, Naples, Italy
    Recent Prog Horm Res 59:31-50. 2004
    ..Extensive evidence indicates that the cardiovascular system responds to the minimal but persistent changes in circulating thyroid hormone levels, which are typical of ..
  10. ncbi Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system
    Donald H Maurice
    Heart and Stroke Foundation of Ontario Career Investigator, Department of Pharmacology and Toxicology, Botterell Hall, A215, Queen s University, Kingston, Ontario, Canada, K7L 3N6
    Mol Pharmacol 64:533-46. 2003
    ..metabolism, contractility, motility, and transcription in virtually all cell types, including those of the cardiovascular system. Considerable effort over the last 20 years has allowed identification of the cellular components involved ..
  11. ncbi Cardiovascular effects of DPP-4 inhibition: beyond GLP-1
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Faculty of Medicine, Padova, Italy
    Vascul Pharmacol 55:10-6. 2011
    ..It has been shown that GLP-1 signaling is also active in the cardiovascular system, where it may exert beneficial effects...
  12. pmc CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators
    Katherine E Wiley
    Clinical Pharmacology Unit, School of Clinical Medicine, Centre for Clinical Investigation, University of Cambridge, Box 110, Level 6, Cambridge CB2 2QQ
    Br J Pharmacol 143:508-14. 2004
    ..Our objectives were to determine the presence of CRF(2) receptors in the human cardiovascular system using the selective radioligand [(125)I]antisauvagine 30...
  13. ncbi Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly?
    Michael Gekle
    Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Magdeburger Strasse 6, 06097 Halle Saale, Germany
    Pflugers Arch 458:231-46. 2009
    ..for cardiovascular electrophysiology and rhythmogenesis, represent the good face of aldosterone in the cardiovascular system. Triggering of persistent arterial hypertension with all the detrimental secondary effects on heart, ..
  14. pmc O-GlcNAc signaling in the cardiovascular system
    Gladys A Ngoh
    Institute of Molecular Cardiology, University of Louisville, 580 South Preston St, 404C, Baxter II 404C, Louisville, KY 40202, USA
    Circ Res 107:171-85. 2010
    ..In this review, we focus on the emerging evidence of its involvement in the cardiovascular system. In particular, we highlight evidence of protein O-GlcNAcylation as an autoprotective alarm or stress ..
  15. ncbi Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system
    P H Chu
    UCSD Salk Program in Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0613, USA
    Mech Dev 95:259-65. 2000
    ..three highly-related genes indicates that they are expressed in an overlapping pattern in the developing cardiovascular system, and skeletal muscle...
  16. ncbi cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling
    Miles D Houslay
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Circ Res 100:950-66. 2007
    ....
  17. ncbi The in vivo cardiovascular effects of box jellyfish Chironex fleckeri venom in rats: efficacy of pre-treatment with antivenom, verapamil and magnesium sulphate
    Sharmaine Ramasamy
    Monash Venom Group, Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
    Toxicon 43:685-90. 2004
    ..We show for the first time, the cardiovascular effects of a C. fleckeri venom sample free of tentacular contamination and the potential of MgSO(4) as an adjunct therapy for the treatment of potentially fatal C. fleckeri envenomings...
  18. ncbi Salt, aldosterone, and insulin resistance: impact on the cardiovascular system
    Guido Lastra
    Division of Endocrinology and Diabetes, Department of Internal Medicine, University of Missouri School of Medicine, D109 HSC Diabetes Center, One Hospital Drive, Columbia, MO 65212, USA
    Nat Rev Cardiol 7:577-84. 2010
    ..is not limited to classic insulin-sensitive tissues such as skeletal muscle, but it also affects the cardiovascular system, where it participates in the development of CVD and CKD...
  19. ncbi Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes
    Hemant Poudyal
    School of Biomedical Sciences, The University of Queensland, Brisbane, Australia
    Am J Physiol Endocrinol Metab 302:E1472-82. 2012
    ..These results suggest that chronic H diet feeding for 32 wk mimics the diet-induced cardiovascular and metabolic changes in middle age and that chia seed may serve as an alternative dietary strategy in the management of these changes...
  20. ncbi Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy
    Ines Pagel-Langenickel
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Med (Berl) 85:797-810. 2007
    ..NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in ..
  21. ncbi Redox signaling in central neural regulation of cardiovascular function
    Matthew C Zimmerman
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City 52245, USA
    Prog Biophys Mol Biol 84:125-49. 2004
    ..The main objective of this review is to discuss the recent progress and prospects for this new field of central redox signaling in cardiovascular regulation, while also addressing the molecular tools that have spurred it forward...
  22. pmc Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish development
    John P Incardona
    Ecotoxicology and Environmental Fish Health Program, Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, Washington 98112, USA
    Environ Health Perspect 113:1755-62. 2005
    ..These findings have multiple implications for the assessment of PAH impacts on coastal habitats...
  23. ncbi Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels
    Reza Sharif-Naeini
    IPMC CNRS, 660 route des Lucioles, Universite de Nice Sophia Antipolis, 06560 Valbonne, France
    J Mol Cell Cardiol 48:83-9. 2010
    ..TRPC6 is also involved in load-induced cardiac hypertrophy. In this review, we will focus on the molecular basis of pressure sensing in the cardiovascular system and associated disease states.
  24. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
    ..More generally, the model predicts structural and functional properties of vertebrate cardiovascular and respiratory systems, plant vascular systems, insect tracheal tubes, and other distribution networks...
  25. ncbi Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases!
    Ling Li
    Pharmaceutical Science Division, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE19NH, UK
    Pharmacol Ther 123:386-400. 2009
    ..Within the cardiovascular system, for example, all are vasodilators, promote angiogenesis and vascular remodelling and are protective ..
  26. ncbi Genetic mechanisms controlling cardiovascular development
    Jamie Bentham
    Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
    Ann N Y Acad Sci 1123:10-9. 2008
    ..A long-term goal in CHD is to manipulate these pathways to enhance buffering and prevent disease in a manner analogous to the use of folate in preventing neural tube defects...
  27. ncbi A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexes
    Yan hua Du
    J Appl Physiol 102:9-10. 2007
  28. ncbi Pharmacologically distinct cardiovascular effects of box jellyfish (Chironex fleckeri) venom and a tentacle-only extract in rats
    Sharmaine Ramasamy
    Monash Venom Group, Department of Pharmacology, Monash University, VIC 3800, Australia
    Toxicol Lett 155:219-26. 2005
    ..We show, for the first time, that a pure venom sample extracted from C. fleckeri nematocysts and a tentacle extract have cardiovascular effects in the anaesthetised rat which are different and pharmacologically distinct...
  29. ncbi Cross-talk between the kidney and the cardiovascular system
    Kerstin Amann
    Department Pathology, Friedrich Alexander University Erlangen, Erlangen, Germany
    J Am Soc Nephrol 17:2112-9. 2006
    ..The mechanisms that link dysfunction of the kidney and the cardiovascular system are being sought...
  30. ncbi Development-related changes in the expression of shear stress responsive genes KLF-2, ET-1, and NOS-3 in the developing cardiovascular system of chicken embryos
    Bianca C W Groenendijk
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 230:57-68. 2004
    ..We demonstrate overlapping expression patterns of KLF-2 and NOS-3 in the narrow parts of the cardiovascular system, like the cardiac inflow tract, the atrioventricular canal, outflow tract, and in the early stages in the ..
  31. ncbi Potentiation of baroreceptor reflex response by heat shock protein 70 in nucleus tractus solitarii confers cardiovascular protection during heatstroke
    P L Li
    Department of Biological Science and Center for Neuroscience, National Sun Yat-Sen University, Taiwan, Republic of China
    Circulation 103:2114-9. 2001
    ....
  32. pmc Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 116:709-15. 2008
    ..Exposure to fine particulate air pollution is associated with increased cardiovascular morbidity and mortality. We previously demonstrated that exposure to dilute diesel exhaust causes vascular dysfunction in humans...
  33. ncbi Vitamin D and the cardiovascular system
    Jorge N Artaza
    Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Clin J Am Soc Nephrol 4:1515-22. 2009
    ....
  34. ncbi Endothelins and NADPH oxidases in the cardiovascular system
    Karigowda J Dammanahalli
    Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Clin Exp Pharmacol Physiol 35:2-6. 2008
    ..Rac1 is an important regulator of NADPH oxidase. There is ample evidence supporting direct stimulation by Rac1 of NADPH oxidase activity. In addition, Rac1-induced cardiomyocyte hypertrophy is mediated by the generation of ROS...
  35. ncbi An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease
    Jixin Zhong
    Davis Heart and Lung Research Institute and Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA
    Atherosclerosis 226:305-14. 2013
    ..Several prospective randomized controlled clinical trials in humans with established atherosclerosis are testing the effects of DPP4 inhibition on hard cardiovascular events...
  36. ncbi Free radical biology of the cardiovascular system
    Alex F Chen
    Department of Surgery, McGowan Institute of Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Sci (Lond) 123:73-91. 2012
    ..much enthusiasm for the continued use of antioxidants to mitigate free-radical-induced changes in the cardiovascular system. In the present paper, we review the clinical use of antioxidants by providing the rationale for their use ..
  37. ncbi NO as a mediator during the early development of the cardiovascular system in the zebrafish
    Bernd Pelster
    Department of Zoology and Limnology, University of Innsbruck, Austria
    Comp Biochem Physiol A Mol Integr Physiol 142:215-20. 2005
    As a general pattern innervation of the cardiovascular system appears late during development in vertebrate embryos, and cardiovascular control may be achieved by hormonal activity in early stages...
  38. ncbi Cardiovascular responses to hypothalamic arcuate nucleus stimulation in the rat: role of sympathetic and vagal efferents
    Takeshi Nakamura
    Department of Neurological Surgery, MSB H 586, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    Hypertension 54:1369-75. 2009
    ....
  39. ncbi Beta 3-adrenoceptors in the cardiovascular system
    Chantal Gauthier
    INSERM U533, l institut du thorax, Nantes, France
    Clin Hemorheol Microcirc 37:193-204. 2007
    ..of a new beta-adrenoceptor subtype, beta(3), in addition to beta(1) and beta(2)-adrenoceptor in the cardiovascular system has changed the view of the roles of the sympathetic system...
  40. ncbi Na+/H+ exchange inhibition delays the onset of hypovolemic circulatory shock in pigs
    Dongmei Wu
    Department of Research, Division of Neonatology, Mount Sinai Medical Canter, Miami Beach, Florida 33140, USA
    Shock 29:519-25. 2008
    ..We conclude that NHE-1 inhibition attenuates ischemic myocardial hypercontracture, cardiovascular decompensation, delays the onset of hypovolemic circulatory shock, and prevents early death in severe hemorrhage...
  41. ncbi Is hypertension an inflammatory disease?
    Jian Jun Li
    Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan 430060, People s Republic of China
    Med Hypotheses 64:236-40. 2005
    ....
  42. ncbi Sex and the cardiovascular system: the intriguing tale of how women and men regulate cardiovascular function differently
    Virginia H Huxley
    Department of Medical Pharmacology and Physiology, Center for Gender Physiology and Environmental Adaptation, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Adv Physiol Educ 31:17-22. 2007
    ..This article focuses on the cardiovascular system, with examples of sex differences in the control of coronary function, blood pressure, and volume...
  43. ncbi Assessment of the cardiovascular system in pediatric chronic kidney disease: a pilot study
    Jutta Muscheites
    Department of Pediatrics, University of Rostock, Rostock, Germany
    Pediatr Nephrol 23:2233-9. 2008
    ..Therefore, routine assessment of FMD may be a useful tool to identify CKD patients at risk of progressive cardiovascular morbidity...
  44. ncbi The pharmacology of Malo maxima jellyfish venom extract in isolated cardiovascular tissues: A probable cause of the Irukandji syndrome in Western Australia
    Ran Li
    Cardiovascular Therapeutics Unit, Department of Pharmacology, The University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia
    Toxicol Lett 201:221-9. 2011
    ..These effects are consistent with the catecholamine excess thought to cause Irukandji syndrome, with additional actions of CGRP release...
  45. ncbi Nprl3 is required for normal development of the cardiovascular system
    Monika S Kowalczyk
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK
    Mamm Genome 23:404-15. 2012
    ..NPRL3 is a candidate gene for harbouring mutations in individuals with developmental abnormalities of the cardiovascular system.
  46. ncbi Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes
    Mariam H M Yousif
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait
    Pharmacol Res 66:269-75. 2012
    ..Collectively, these data shed new insights into the likely mechanism of action through which the ACE2/Ang-(1-7)/Mas receptor axis prevents Type 1 diabetes-induced cardiovascular dysfunction...
  47. pmc Estrogen, aging and the cardiovascular system
    James P Stice
    Molecular and Cellular Cardiology, University of California Davis, Davis, CA 95616, USA
    Future Cardiol 5:93-103. 2009
    ..Estrogens may decrease the expression of soluble epoxide hydrolase, which has deleterious effects on the cardiovascular system through metabolism of epoxyeicosatrienoic acids...
  48. ncbi Role for primary cilia as flow detectors in the cardiovascular system
    Kim Van der Heiden
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Int Rev Cell Mol Biol 290:87-119. 2011
    The cardiovascular system is exposed to biochemical and biomechanical signals...
  49. pmc Cardiovascular function of a glutamatergic projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarius in the rat
    T Kawabe
    Department of Neurological Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Neuroscience 153:605-17. 2008
    ....
  50. ncbi Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system
    W S Post
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cardiovasc Res 43:985-91. 1999
    ..In this study, we sought to determine whether such age-related methylation occurs in the cardiovascular system, and whether it is associated with atherosclerotic disease.
  51. ncbi Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats
    Katsuhiko Noguchi
    Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Toxicon 45:519-26. 2005
    ..Data show that C. quadrigatus venom has both vasoconstrictor and cardiodepressive effects in rats, and suggest that a calcium channel blocker can protect against the cardiovascular and lethal effects of the venom...
  52. ncbi Pharmacology of gap junctions in the cardiovascular system
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Cardiovasc Res 62:287-98. 2004
    ..channels provide the basis for intercellular communication and play an important physiological role in the cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular tone, endothelial function and ..
  53. ncbi Developmental toxicity screening in zebrafish
    Catherine W McCollum
    Center for Nuclear Receptors and Cell Signaling, University of Houston, Texas 77204, USA
    Birth Defects Res C Embryo Today 93:67-114. 2011
    ..We also compare the available data in zebrafish toxicity assays with two databases containing mammalian toxicity data. Finally, we identify gaps in our collective knowledge that are ripe for future studies...
  54. ncbi 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT)
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
    Clin Exp Pharmacol Physiol 33:575-83. 2006
    ..6. In summary, the function of SERT in the CV system is just beginning to be revealed...
  55. pmc Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in a mevinphos intoxication model of brain stem death
    S H H Chan
    Center for Translational Researchin Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Br J Pharmacol 164:2015-28. 2011
    ..We investigated the role of tropomyocin receptor kinase B (TrkB) and its downstream signalling pathways in the rostral ventrolateral medulla (RVLM) during experimental brain stem death...
  56. ncbi Differences in the responses of the pituitary beta-endorphin and cardiovascular system to ethanol and stress as a function of family history
    Xing Dai
    Department of Psychiatry, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    Alcohol Clin Exp Res 26:1171-80. 2002
    ..These studies investigated the response of pituitary beta-endorphin to stress and the effect of alcohol on the stress response in subjects at low (LR) and high (HR) risk of alcoholism, as determined from their family history...
  57. ncbi Cardiovascular effects of adrenocorticotropin microinjections into the rostral ventrolateral medullary pressor area of the rat
    Tetsuya Kawabe
    Department of Neurological Surgery, MSB H 586, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, 07103, USA
    Brain Res 1102:117-26. 2006
    ..This is the first report showing central cardiovascular actions of ACTH...
  58. ncbi Estrogen and the cardiovascular system
    A A Knowlton
    Molecular and Cellular Cardiology, Department of Medicine, University of California, Davis, CA 95616, USA
    Pharmacol Ther 135:54-70. 2012
    ..Further basic research into the underlying molecular mechanisms of estrogen's actions is essential to provide a better comprehension of the many properties of this powerful hormone...
  59. ncbi TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology
    Hugues Abriel
    Department of Clinical Research, Swiss National Centre of Competence in Research NCCR TransCure, University of Bern, Switzerland
    Biochem Pharmacol 84:873-81. 2012
    ..These channels are widely expressed in many different tissues, including those of the cardiovascular system. The transient receptor potential channel melastatin 4 (TRPM4) is a Ca(2+)-activated non-specific cationic ..
  60. pmc Differential engagements of glutamate and GABA receptors in cardiovascular actions of endogenous nNOS or iNOS at rostral ventrolateral medulla of rats
    Samuel H H Chan
    Center for Neuroscience, National Sun Yat Sen University, Kaohsiung 80424, Taiwan, Republic of China
    Br J Pharmacol 138:584-93. 2003
    ..In addition, whereas NO derived from nNOS induced sympathoexcitation via both NMDA and non-NMDA receptors in the RVLM, NO generated by iNOS elicited sympathoinhibition via GABA(A) receptors...
  61. ncbi Incorporating autoregulatory mechanisms of the cardiovascular system in three-dimensional finite element models of arterial blood flow
    H J Kim
    Department of Aerospace Engineering Sciences, University of Colorado at Boulder, Boulder, CO 80309, USA
    Ann Biomed Eng 38:2314-30. 2010
    The cardiovascular system is a closed-loop system in which billions of vessels interact with each other, and it enables the control of the systemic arterial pressure and varying organ flow through autoregulatory mechanisms...
  62. ncbi Adipokines and the cardiovascular system: mechanisms mediating health and disease
    Josette M Northcott
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 90:1029-59. 2012
    This review focuses on the role of adipokines in the maintenance of a healthy cardiovascular system, and the mechanisms by which these factors mediate the development of cardiovascular disease in obesity...
  63. ncbi Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants
    Laurent Dupays
    Laboratoire de Génétique et Physiologie du Développement UMR CNRS 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
    J Mol Cell Cardiol 38:787-98. 2005
    ..To evaluate this correlation, the expression of Cxs has been investigated in the cardiovascular system of wild-type and Nkx2-5-/- 9.2 days post-conception (dpc) mouse embryos...
  64. ncbi Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system
    Yoh Takuwa
    Department of Physiology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Biochim Biophys Acta 1781:483-8. 2008
    ..These results provide evidence for S1P receptor subtype-specific pharmacological intervention as a novel therapeutic approach to cardiovascular diseases and cancer...
  65. ncbi Hypoxia-inducible factor and the development of stem cells of the cardiovascular system
    D L Ramirez-Bergeron
    Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Stem Cells 19:279-86. 2001
    ..to our understanding of the role hypoxia plays during early embryonic development in general and the cardiovascular system in particular...
  66. ncbi Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos
    P V AshaRani
    Department of Chemistry, National University of Singapore, Singapore
    Nanotoxicology 5:43-54. 2011
    ..The toxic effects exhibited by the zebrafish embryos as a consequence of nanoparticle exposure, accompanied by the accumulation of metals inside the body calls for urgent further investigations in this field...
  67. ncbi Modifications of the cardiovascular system with aging
    Alberto U Ferrari
    Cardioriabilitazione, Ospedale di Seregno, Az Osp Vimercate MI, Centro di Fisiologia Clinica e Ipertensione, Universita di Milano Bicocca, Via F Sforza, 35, 20122 Milan, Italy
    Am J Geriatr Cardiol 11:30-3. 2002
    ..Arterial baroreceptor control of blood pressure is largely preserved in advanced age, whereas cardiopulmonary-mediated reflex responses are definitely impaired...
  68. ncbi Autophagy in the cardiovascular system
    Guido R Y De Meyer
    Division of Pharmacology, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Biochim Biophys Acta 1793:1485-95. 2009
    ....
  69. ncbi Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos
    Lori Hartnett
    Department of Biochemistry, National University of Ireland, Galway, Ireland
    Int J Dev Biol 54:573-83. 2010
    ..in ventralised embryos with reduced growth, reduced eyes, disrupted brain structures and a disrupted cardiovascular system, with igf-2b playing a more significant role in development...
  70. pmc Matricryptic sites control tissue injury responses in the cardiovascular system: relationships to pattern recognition receptor regulated events
    George E Davis
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Mol Cell Cardiol 48:454-60. 2010
    This review addresses new concepts related to the importance of how cells within the cardiovascular system respond to matricryptic sites generated from the extracellular matrix (ECM) following tissue injury...
  71. ncbi Value of a cardiovascular limited ultrasound examination using a hand-carried ultrasound device on clinical management in an outpatient medical clinic
    Bruce J Kimura
    Scripps Mercy Hospital, San Diego, California, USA
    Am J Cardiol 100:321-5. 2007
    ..In conclusion, when applied to a clinic population, brief cardiovascular ultrasound exams frequently demonstrate unsuspected findings that can change management...
  72. ncbi Hydrogen sulfide and oxygen sensing in the cardiovascular system
    Kenneth R Olson
    Indiana University School of Medicine, South Bend Center, South Bend, Indiana 46617, USA
    Antioxid Redox Signal 12:1219-34. 2010
    ..These studies also indicate that, under normoxic conditions, it is doubtful that free H(2)S has longer than a transient existence in tissue or extracellular fluid...
  73. pmc Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanisms
    Sudesh Vasdev
    Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, Health Sciences Centre, St John s, Newfoundland, Canada
    Vasc Health Risk Manag 2:263-76. 2006
    ..In conclusion, we suggest that chronic low ethanol intake confers its beneficial effect mainly through its ability to increase antioxidant capacity and lower AGEs...
  74. ncbi Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system
    Chaoshu Tang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing, People s Republic of China
    Curr Vasc Pharmacol 4:17-22. 2006
    ..The genomic basis of cystathioninuria in humans is 2 nonsense and 2 sense mutations in CSE. This review reveals that H(2)S is a new endogenous gaseous transmitter in the cardiovascular system.
  75. ncbi Numerical simulation of cardiovascular dynamics with different types of VAD assistance
    Yubing Shi
    Department of Engineering, Queen Mary, University of London, London, UK
    J Biomech 40:2919-33. 2007
    ..Similarly, three pumping modes are modelled: constant flow; counterpulsation and copulsation. The cardiovascular system is modelled using an approach developed previously, using the concentrated parameter method by considering ..
  76. ncbi Periconceptional nutrition programs development of the cardiovascular system in the fetal sheep
    L J Edwards
    Department of Physiology, University of Adelaide, Adelaide SA 5005, South Australia
    Am J Physiol Regul Integr Comp Physiol 283:R669-79. 2002
    It has been proposed that fetal adaptations to intrauterine nutrient deprivation permanently reprogram the cardiovascular system. We investigated the impact of restricted periconceptional nutrition and/or restricted gestational nutrition ..
  77. ncbi Landmarks in understanding the central nervous control of the cardiovascular system
    John H Coote
    Division of Neuroscience, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Exp Physiol 92:3-18. 2007
    ..Lecture I have tried to trace the key experiments that have developed ideas on how the brain regulates the cardiovascular system. It is a personal view and inevitably, owing to constraints on space and time, I have not been able to ..
  78. pmc Effects of tetrodotoxin on the mammalian cardiovascular system
    Thomas Zimmer
    Institute of Physiology II, Friedrich Schiller University, Kollegiengasse 9, 07743 Jena, Germany
    Mar Drugs 8:741-62. 2010
    ..Altogether, these data strongly suggest that TTX sensitive Na+ channels, detected more recently in various heart tissues, are not involved in excitation phenomena in the healthy adult heart of higher mammals...
  79. pmc NO/redox disequilibrium in the failing heart and cardiovascular system
    Joshua M Hare
    Johns Hopkins University School of Medicine, Department of Medicine, Cardiology Division, Baltimore, Maryland 21205, USA
    J Clin Invest 115:509-17. 2005
    ..tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels ..
  80. ncbi Omega-3 fatty acids and cardiovascular disease
    Clemens von Schacky
    Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Curr Opin Clin Nutr Metab Care 10:129-35. 2007
    ..EPA and DHA have advanced from scientific research into everyday practice, a development reviewed here...
  81. ncbi Thioredoxin in the cardiovascular system
    Cameron J World
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY, USA
    J Mol Med (Berl) 84:997-1003. 2006
    ..TRX and its endogenous regulators may represent important future targets to develop clinical therapies for diseases associated with oxidative stress...
  82. ncbi Proprotein convertases: lessons from knockouts
    Nathalie Scamuffa
    INSERM U716 Equipe AVENIR, Institut de Genetique Moleculaire, 27 rue Juliette Dodu, 75010 Paris, France
    FASEB J 20:1954-63. 2006
    ....
  83. ncbi Development of a mathematical model of the human circulatory system
    Martin J Conlon
    Department of Mechanical and Aerospace Engineering, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada
    Ann Biomed Eng 34:1400-13. 2006
    ..The mathematical model produces reasonable systemic pressure and flow behaviour, and graphs of this data are included...
  84. ncbi Sex hormones and the cardiovascular system: effects on arterial function in women
    H J Teede
    The Jean Hailes Foundation for Women s Health, Monash Institute for Health Services Research and Diabetes Unit, Southern Health, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 34:672-6. 2007
    ..The data on arterial function reviewed herein, along with emerging interventional human studies, suggest that the cardiovascular effects of this practice are not adverse...
  85. ncbi Acute effects of fine particles on cardiovascular system: differences between the spontaneously hypertensive rats and wistar kyoto rats
    Jinzhuo Zhao
    Department of Environment Health, School of Public Health, Fudan University, Shanghai, China
    Toxicol Lett 193:50-60. 2010
    ..The results indicated that ambient fine particles which entered into lungs could influence the cardiovascular system. When exposed to fine particles, SHR exhibited more severe cardiovascular injury in comparison to WKY rats...
  86. ncbi Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis
    Shelley R Salpeter
    Santa Clara Valley Medical Center, San Jose, CA, USA
    Chest 125:2309-21. 2004
    ..beta(2)-Agonist use in patients with obstructive airway disease has been associated with an increased risk for myocardial infarction, congestive heart failure, cardiac arrest, and acute cardiac death...
  87. ncbi Alcohol and the cardiovascular system: research challenges and opportunities
    Diane L Lucas
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism NIH, Bethesda, MD, USA
    J Am Coll Cardiol 45:1916-24. 2005
    ..National Heart, Lung, and Blood Institute sponsored a state-of-the-art workshop on "Alcohol and the Cardiovascular System: Research Challenges and Opportunities" in Bethesda, Maryland, in May 2003...
  88. ncbi The complex pattern of SMAD signaling in the cardiovascular system
    Gerhild Euler-Taimor
    Physiologisches Institut, Justus Liebig Universitat Giessen, Aulweg 129, 35392 Giessen, Germany
    Cardiovasc Res 69:15-25. 2006
    ..On the other hand, activation of SMADs by TGFbeta family members results in fibrotic, apoptotic, and anti-hypertrophic processes that are related to a detrimental cardiac remodeling and progression to heart failure...
  89. ncbi Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages
    Steven J Kattman
    Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 11:723-32. 2006
    ..Isolation and characterization of this previously unidentified population suggests that the mammalian cardiovascular system develops from multipotential progenitors.
  90. ncbi Blockade of 5-HT2A receptors suppresses hyperthermic but not cardiovascular responses to psychosocial stress in rats
    M I Beig
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2038, Australia
    Neuroscience 159:1185-91. 2009
    ....
  91. pmc Short-term complexity of cardiac autonomic control during sleep: REM as a potential risk factor for cardiovascular system in aging
    Antoine U Viola
    Centre for Chronobiology, University of Basel, Basel, Switzerland
    PLoS ONE 6:e19002. 2011
    ..The aim of our study was to evaluate the HRV complexity using two entropy-derived measures, Shannon Entropy (SE) and Corrected Conditional Entropy (CCE), during sleep in young and older subjects...
  92. pmc A multiformalism and multiresolution modelling environment: application to the cardiovascular system and its regulation
    Alfredo I Hernandez
    INSERM, U642, Rennes 35000, France
    Philos Trans A Math Phys Eng Sci 367:4923-40. 2009
    ..The pioneering model of the overall regulation of the cardiovascular system proposed by Guyton and co-workers in 1972 has been implemented under M2SL and a pulsatile ventricular ..
  93. ncbi Efficient implementation of non-linear valve law and ventricular interaction dynamics in the minimal cardiac model
    C E Hann
    Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Comput Methods Programs Biomed 80:65-74. 2005
    ..More specifically, a short 20-beat simulation that took 102 s now requires 4.3 s, significantly improving the model's potential for practical use in a diagnostic and/or decision support role in the intensive care unit...
  94. ncbi Prenatal high salt programs enhanced sympathoadrenal activation of the cardiovascular response to restraint
    James P Porter
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Auton Neurosci 150:140-3. 2009
    ..These data suggest that the prenatal high salt programmed a sympathoadrenal hyperresponsiveness to restraint stress...
  95. ncbi Coenzyme q10 confers cardiovascular protection against acute mevinphos intoxication by ameliorating bioenergetic failure and hypoxia in the rostral ventrolateral medulla of the rat
    David H T Yen
    Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Shock 23:353-9. 2005
    ....
  96. ncbi Multi-scale modeling of the human cardiovascular system with applications to aortic valvular and arterial stenoses
    Fuyou Liang
    Computational Science Research Program, RIKEN, Wako, Saitama, Japan
    Med Biol Eng Comput 47:743-55. 2009
    A computational model of the entire cardiovascular system is established based on multi-scale modeling, where the arterial tree is described by a one-dimensional model coupled with a lumped parameter description of the remainder...
  97. ncbi Comparative analysis of methods for classifying the cardiovascular system's states under stress
    V S Anishchenko
    Radiophysics and Nonlinear Dynamics Department, Saratov State University, Russia
    Crit Rev Biomed Eng 29:462-81. 2001
    ..This analysis was carried out by using standard nonlinear-dynamics algorithms and methods. Apart from that, we assessed the expediency of using a number of characteristics to classify the cardiovascular system's state under stress.
  98. ncbi Steroid hormones and the cardiovascular system: direct actions of estradiol, progesterone, testosterone, gluco- and mineralcorticoids, and soltriol [vitamin D] on central nervous regulatory and peripheral tissues
    W E Stumpf
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599
    Experientia 46:13-25. 1990
    ..These data indicate that all steroid hormones exert direct actions on the cardiovascular system at its different levels of organization, thus enabling adjustment to the changing demands during ..
  99. ncbi Simulation of hemodynamic responses to the valsalva maneuver: an integrative computational model of the cardiovascular system and the autonomic nervous system
    Fuyou Liang
    Graduate School of Science and Technology, Chiba University, Chiba, Japan
    J Physiol Sci 56:45-65. 2006
    ..In the present study, a computational model of the cardiovascular system (CVS) and its interaction with the autonomic nervous system (ANS) was developed for the purpose of ..
  100. ncbi Nongenomic effects of mineralocorticoid receptor activation in the cardiovascular system
    Anastasia S Mihailidou
    Department of Cardiology, Royal North Shore Hospital, University of Sydney, Sydney 2065, Australia
    Steroids 70:347-51. 2005
    ....
  101. ncbi Pharmacogenomics of drugs affecting the cardiovascular system
    Gerard Siest
    INSERM U 525, Centre du Medicament, Faculte de Pharmacie, Universite Henri Poincare Nancy I, Nancy, France
    Clin Chem Lab Med 41:590-9. 2003
    ..From the risk concept emphasizing impaired metabolism and adverse effects, we now moved to an approach, which is a personalized, genotype-dependent adaptation of therapy...

Research Grants65

  1. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..These issues are paramount to understanding the effects of hypoxia on the cardiovascular system and the pathology of OSA, particularly the hypertension associated with this disease...
  2. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012
    ..She has gained expertise in fetal physiology (especially of the cardiovascular system) and is well-versed in the literature surrounding the developmental origins of health and cardiovascular ..
  3. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..aim is to understand why atherosclerosis, also known as the "hardening of blood vessels," occurs in cardiovascular system. It is clear that chemical change of low density lipoprotein (LDL), which contains "bad cholesterol," is ..
  4. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2013
    ..She has gained expertise in fetal physiology (especially of the cardiovascular system) and is well-versed in the literature surrounding the developmental origins of health and cardiovascular ..
  5. A Rodent Model to Study Links Among Diet, Visceral Adipose and Cardiomyopathy
    MELINDA ANN FRYE; Fiscal Year: 2013
    ..Additionally, Dr. Frye's clinical and research interest in the cardiovascular system is longstanding, and her investigations focused on disease attributed to obesity demonstrate a commitment ..
  6. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..In contrast to mice, the physiology and anatomy of the porcine cardiovascular system closely resembles that of humans...
  7. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..of observational and experimental studies have shown that an inflammatory oxidative environment in the cardiovascular system can lead to pathologic changes in the endothelium and contribute to atherosclerosis...
  8. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..In contrast to mice, the physiology and anatomy of the porcine cardiovascular system closely resembles that of humans...
  9. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2010
    ..Both, CMG-1 and PC1 are expressed in the embryonic cardiovascular system and are upregulated during capillary morphogenesis...
  10. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
    ..persistent organ failure, which is defined as persisting for 48 or more hours and involves the cardiovascular system, the pulmonary system, and/or the kidneys...
  11. Autoimmunity in the Mediation of Infectious Myocarditis
    Jay Reddy; Fiscal Year: 2013
    ..The long-term goal is to determine the autoimmune mechanisms of pathogens that commonly infect the cardiovascular system and initiate heart autoimmunity...
  12. Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?
    Bryce Binstadt; Fiscal Year: 2012
    ..provided by applicant): Many systemic autoimmune diseases affect both the synovial joints and the cardiovascular system. For example, patients with rheumatoid arthritis or systemic lupus erythematosus (SLE) are at increased ..
  13. Regulation Of Inorganic Phosphorus (Pi) Metabolism By Estrogen
    Hassane Amlal; Fiscal Year: 2013
    ..an important and efficient therapeutic tool that can prevent hyperphosphatemia and its adverse effects on cardiovascular system in conditions associated with parathyroid gland dysfunction...
  14. A PROOF-OF-CONCEPT CLINICAL TRIAL OF XENIN-25 IN THE TREATMENT OF TYPE 2 DIABETES
    Burton M Wice; Fiscal Year: 2010
    ..Efficacy is frequently short lived and potentially serious side effects particularly in the cardiovascular system have been reported...
  15. Endogenous Cardiac Glycosides in AASK
    Brad C Astor; Fiscal Year: 2010
    ..These hormones are significantly higher in persons with CKD, and may have effects on the cardiovascular system through several different pathways...
  16. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    ..applicant): Physiological changes including menopause and ovariectomy induce irreversible changes in the cardiovascular system that frequently result in diminished endothelium-dependent regulation of vascular tone and can lead to ..
  17. Crosstalk between estrogen and bile acid signaling pathway
    Ruitang Deng; Fiscal Year: 2013
    ..estrogen exerts a vast range of biological effects in nonclassical endocrine organ systems, such as cardiovascular system and liver...
  18. Purinergic signaling in sleep apnea
    Elzbieta Kaczmarek; Fiscal Year: 2012
    ..The mechanisms by which OSA affects the cardiovascular system may result from excursions in intrathoracic pressure, increased sympathetic activation, and subsequent ..
  19. Release of FGF1 and Pathology of Angiogenesis
    Igor Prudovsky; Fiscal Year: 2010
    ..FGF1 is a potent pro-angiogenic growth factor which participates in the development of cardiovascular system, its maintenance and response to damage...
  20. Cell Death in Alcoholic Heart and Muscle
    Emanuel Rubin; Fiscal Year: 2013
    ..Stress and Tissue Injury Unit at NIAAA, who is a leader in research of oxidative/nitrosative stress in the cardiovascular system. Thus, the PIs'experience in calcium and Bcl-2 family protein-mediated mitochondrial stress and the ..
  21. Role of nuclear receptors in origin and differentiation of spermatozoa
    ADAM MICHAEL REITZEL; Fiscal Year: 2011
    ..superfamily, have pleiotropic roles in embryogenesis including roles in development of the nervous and cardiovascular system and in cancer due to expression in various embryonal carcinoma cell lines...
  22. Keratin biomaterial-based fluid for trauma resuscitation
    LUKE BURNETT; Fiscal Year: 2010
    ..effect by bringing more fluid into the circulation without instigating adverse interactions within the cardiovascular system, [Preclinical] blood and tissues...
  23. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    ..algorithms and system physical changes can be simulated including replacing the MCS model with a human cardiovascular system model...
  24. CELLULAR AND MOLECULAR BASES FOR RHYTHMIC GNRH RELEASE
    Suzanne M Moenter; Fiscal Year: 2013
    ..alter development and function of many systems, for example, bone, the central nervous system and the cardiovascular system. Episodic release of gonadotropin-releasing hormone (GnRH) is required for fertility in all vertebrates of ..
  25. NOVEL APPROACHES FOR REGULATION OF IGF-1 LEVELS THROUGHOUT THE LIFESPAN
    William Edmund Sonntag; Fiscal Year: 2013
    ..are numerous studies that have reported beneficial effects of GH and/or IGF-1 replacement on the aging cardiovascular system and an overwhelming database indicating beneficial effects of these hormones on the aging brain...
  26. Obesity, vascular inflammation, and immune cell activation in prehypertension
    Suzi Hong; Fiscal Year: 2013
    ..challenge and Trier Social Stress Test are reliable and robust stress paradigms to investigate immune and cardiovascular system responses under neuroendocrine activation...
  27. Mechanisms of Cardiac Afferents and CNS Reflex Processing
    John C Longhurst; Fiscal Year: 2013
    ..Additional knowledge derived from these studies will allow a better understanding of the mechanisms underlying the genesis of angina pectoris and reflex activation of the cardiovascular system during myocardial ischemia and reperfusion.
  28. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
    ..in deaths from cardiovascular disease, but we know little about how ozone air pollution affects the cardiovascular system. Our proposed studies will determine the effects of ozone on blood vessel and heart function that could ..
  29. Clinical Trail to Reverse Early Arterial Stiffening
    Kim Sutton Tyrrell; Fiscal Year: 2010
    ..effects that lead to increases in blood pressure and arterial stiffness and a premature aging of the cardiovascular system. This leads eventually to chronic hypertension, heart failure and cardiovascular mortality...
  30. Nitroso/redox balance in myocardial infarction
    Joshua M Hare; Fiscal Year: 2013
    ..oxide (NO), a highly versatile signaling molecule, exerts a broad range of regulatory influences in the cardiovascular system that extend from endothelial relaxation to platelet function, myocardial contractility, Ca2+ cycling, and ..
  31. Vagal afferent cell bodies as sensors of blood-borne factors
    STEPHEN JOHN LEWIS; Fiscal Year: 2010
    ..This unique response mechanism may be vital in helping the body to defend the cardiovascular system against disease states that threaten human health such as high blood pressure, inflammation and diabetes.
  32. Human Pluripotent Stem Cell and Progenitor Models of Cardiac and Blood Diseases
    LEONARD IRA ZON; Fiscal Year: 2013
    ..into relevant tissues, and in disease modeling in two major systems of central interest to the NHLBI-the cardiovascular system and the blood...
  33. Myoglobin as a Nitrite Reductase that Regulates Hypoxic Cardiac NO Signaling
    Sruti Shiva; Fiscal Year: 2013
    ..the biological function of myoglobin and the physiological and pharmacological potential of nitrite in the cardiovascular system. PUBLIC HEALTH RELEVANCE: After a heart attack, part of the tissue in the heart dies...
  34. PHOSPHORYLATION AND ENDOTHELIAL NITRIC OXIDE PRODUCTION
    William C Sessa; Fiscal Year: 2013
    ..macrovascular (atheroprotection) and microvascular (angiogenesis and permeability) functions in the cardiovascular system. As a corollary to this hypothesis, we predict that modulating eNOS phosphorylation will delay ..
  35. The roles of primary cilia in cardiovascular system
    SURYA NAULI; Fiscal Year: 2012
    ....
  36. Endothelial NOS by protein to protein interactions
    William C Sessa; Fiscal Year: 2013
    Endothelium-derived nitric oxide (NO) is a critical mediator of diverse functions in the cardiovascular system. During the tenure of this grant, we have developed the concept that eNOS inactivation/activation can be regulated by its ..
  37. Intrauterine hypoxia induces cytokine gene expression in fetal cardiac ventricles
    LASHAUNA C EVANS; Fiscal Year: 2010
    ..Adaptation of the fetal cardiovascular system to hypoxic stress is essential for survival...
  38. Development of a radioligand for assay of angiotensin-converting enzyme-2(ACE-2)
    ROBERT CHARLES SPETH; Fiscal Year: 2013
    ..Ang II receptor subtype to cause pressor, fibrotic, mitogenic, and inflammatory responses that damage the cardiovascular system as well as susceptible target organs, e.g. kidney, heart and brain...
  39. Aging and Myocardial Progenitor Recruitment
    Richard T Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aging of the cardiovascular system is characterized by a reduction in cardiac function, and cardiovascular disease frequently strikes in the latter half of life...
  40. Chlorinated Lipids in Myocardial Ischemia/Reperfusion
    David A Ford; Fiscal Year: 2013
    ..Plasmalogens are a predominant phospholipid subclass in tissues of the cardiovascular system. Based on the discovery that activated neutrophils initiate the accumulation of a family of chlorinated ..
  41. Direct and Bone-Marrow Mediated Effects of Adipose Stem Cells in Emphysema
    Irina Petrache; Fiscal Year: 2013
    ..of airspaces, but also associated with systemic effects on organs that include the bone marrow and the cardiovascular system. Little is known about the mechanisms of systemic illness in emphysema and their impact, if any, on the ..
  42. Disordered Mineral Metabolism in the CKiD Children: Role of FGF-23
    Anthony A Portale; Fiscal Year: 2013
    ..by applicant): Childhood and dolescence are crucial times for the development of a healthy skeletal and cardiovascular system. Chronic kidney disease (CKD) in youth results in metabolic bone disease, resultant growth failure and ..
  43. Model Systems for PXE
    Jouni Uitto; Fiscal Year: 2013
    ..PXE), the paradigm of heritable aberrant mineralization disorders, manifesting in the skin, eyes, and the cardiovascular system with considerable morbidity and mortality...
  44. PGC1alpha and Irisin in the Control of Diabetes and Obesity
    Bruce M Spiegelman; Fiscal Year: 2013
    ..2 diabetes, but they are still inadequate to prevent the negative effects of the Metabolic Syndrome on the cardiovascular system, cancer and other disorders...
  45. PPAR-gamma and Vascular Lesion Formation
    Yuqing Eugene Chen; Fiscal Year: 2013
    ..Thus, the investigation of the molecular mechanisms underlying PPAR-? functions especially in the cardiovascular system are of utmost importance...
  46. INTEGRATIVE NEUROBIOLOGY OF CARDIOVASCULAR REGULATION
    Francois M Abboud; Fiscal Year: 2012
    ..Mark, Rahmouni) will address the coupling of the two major components of neurohumoral drive to the cardiovascular system, namely the sympathetic nervous system and the renal-angiotension-aldosterone system in as determinants of ..
  47. Regulation of Borealin Function by Mitotic Phosphorylation
    William Taylor; Fiscal Year: 2009
    ..Increased proliferation of fibroblasts and smooth muscle cells has also been implicated in diseases of the cardiovascular system, and knowing how Borealin is regulated may also provide insight into this spectrum of diseases.
  48. Role of Ubiquitin in Cardiovascular System
    Song Li; Fiscal Year: 2013
    ..1 ..
  49. CNS AUTONOMIC PATHWAYS: CENTRAL CARDIOVASCULAR CONTROL
    Arthur D Loewy; Fiscal Year: 2012
    ..The studies presented here deal with the brain circuits controlling salt intake, and will provide new insights into the brain pathways which control sodium balance and ultimately, central regulation of the cardiovascular system.
  50. NEUROFIBROMIN, NEURAL CREST AND CARDIAC DEVELOPMENT
    Jonathan A Epstein; Fiscal Year: 2012
    ..competing renewal application to support our ongoing work to explore the function of neurofibromin in the cardiovascular system. Neurofibromin is encoded by the NF1 gene, which is mutated in von Recklinghausen Neurofibromatosis, a ..
  51. Cellular physiology of epilepsy-associated KCNQ2 channels
    ANASTASIOS TZINGOUNIS; Fiscal Year: 2013
    ..Most family members are required for proper function of either the nervous or cardiovascular system as loss of function mutations in Kcnq genes lead to LQTS syndrome (Kcnq1), progressive hearing loss (Kcnq4)..
  52. Role of CYP P450s in the Regulation of Vascular Tone through Adenosine Receptors
    S Jamal Mustafa; Fiscal Year: 2013
    ..acid (AA)-derived metabolites (EETs &20-HETE) through CYP450s have emerged as important mediators in cardiovascular system. However, the relationship between AR's and these metabolites in the regulation of VT is not well ..
  53. Identification of a Stretch-Activated Channel with a Role in Cardiac Development
    Dipayan Chaudhuri; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The ability of the cardiovascular system to sense blood pressure and flow is central to its normal function, becoming altered in diseases such as ..
  54. Dual Function of VPO1 in Pathogen Recognition and Killing
    Guangjie Cheng; Fiscal Year: 2013
    ..VPO1 is highly expressed in the cardiovascular system, lung, liver, pancreas and spleen, and is secreted into bloodstream at a 1000-fold higher concentration ..
  55. Regulation of GPER-mediated Signaling in the Vasculature by Calmodulin
    Kim Tran; Fiscal Year: 2012
    ..goal is to understand the mechanisms of action and roles of GPER in CaM- dependent activities in the cardiovascular system. Data from these studies will enhance our understanding of how estrogen works and provide timely ..
  56. Internalization of S. mutans in vascular endothelial cells
    Ann Progulske-Fox; Fiscal Year: 2013
    ..The commonality of these diseases is that they are diseases of the cardiovascular system. The ability of a pathogen to attach to and invade endothelial tissues has previously been shown to be ..
  57. Mechanisms of ROS Balance and Cardiac Energy Metabolism in Diabetes Mellitus
    SONIA DEL CARMEN CORTASSA; Fiscal Year: 2012
    ..in order to perform a rational intervention in the treatment and prevention of a disease regarding the cardiovascular system, a deeper understanding of the integrated behavior of metabolic networks is needed...
  58. Imaging Nonlinear Control of the Pulmonary Circulation with Proton MRI
    Susan R Hopkins; Fiscal Year: 2013
    ..and was lost in brain death suggesting that nonlinear control is a critical feature of a healthy human cardiovascular system. Nonlinear forecasting yields a set of metrics that provide information on the type of nonlinear ..
  59. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2010
    The overall objective of our research program is to understand the regulation of ion channels in the cardiovascular system. We made a novel observation that the large conductance Ca2+-activated K+ (BK) channels are targeted to caveolae ..
  60. Short-Term Institutional Research Training Grant
    Marlys Hearst Witte; Fiscal Year: 2013
    ..Centers of Excellence focusing on in vivo, in vitro, in situ, in silico and modeling approaches to the cardiovascular system and its disorders (e.g...
  61. Regulation of Blood Pressure by Klotho
    Zhongjie Sun; Fiscal Year: 2013
    ..The results will provide novel mechanism that klotho protects the cardiovascular system. Completion of the project may reveal new insights into therapeutic strategies for hypertension and ..
  62. AUTONOMIC CARDIOVASCULAR REGULATION
    DAVID HERLIE ROBERTSON; Fiscal Year: 2013
    ..provided by applicant): The autonomic nervous system is the crucial link between the brain and the cardiovascular system. It is the final common pathway by which central disturbances - whether initiated by exogenous ..
  63. BAROREFLEX AND POSTERIOR HYPOTHALAMIC NEUROPEPTIDE-Y
    John Martin; Fiscal Year: 1991
    ..the cholinergic system of the posterior hypothalamic nucleus (PHN) plays a role in the regulation of the cardiovascular system by affecting autonomic nervous and endocrine systems...
  64. Y Receptor In and Cardiovascular Function From the PHN
    John Martin; Fiscal Year: 2004
    ..to understand the relationship between NPY and acetylcholine in the PHN with respect to the control of the cardiovascular system. The hypothesis to be addressed is that NPY stimulates the Y1 receptor subtype within the PHN to activate ..
  65. Abcb11 and Hepatic Transport
    Anne Henkel; Fiscal Year: 2009
    ..function in both normal physiology and in pathophysiologic diseases of the liver, biliary tract, and cardiovascular system. The rate-limiting step in bile salt transport is canalicular secretion, which is mediated by the bile ..