fingers

Summary

Top Publications

  1. ncbi Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia
    Piero O Bonetti
    Center for Coronary Physiology and Imaging, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 44:2137-41. 2004
  2. ncbi Decoupling the cortical power spectrum reveals real-time representation of individual finger movements in humans
    K J Miller
    Department of Physics, Seattle Children s Research Institute and Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 29:3132-7. 2009
  3. ncbi Coding and use of tactile signals from the fingertips in object manipulation tasks
    Roland S Johansson
    Physiology Section, Department of Integrative Medical Biology, Umea University, SE 901 87 Umea, Sweden
    Nat Rev Neurosci 10:345-59. 2009
  4. ncbi Integration of sensory and motor representations of single fingers in the human cerebellum
    Tobias Wiestler
    Institute of Cognitive Neuroscience, University College London, London, United Kingdom
    J Neurophysiol 105:3042-53. 2011
  5. pmc Developmental basis of sexually dimorphic digit ratios
    Zhengui Zheng
    Howard Hughes Medical Institute and Department of Molecular Genetics and Microbiology and Department of Biology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 108:16289-94. 2011
  6. ncbi 2nd to 4th digit ratios, fetal testosterone and estradiol
    S Lutchmaya
    Developmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
    Early Hum Dev 77:23-8. 2004
  7. ncbi Single-trial reconstruction of finger-pinch forces from human motor-cortical activation measured by near-infrared spectroscopy (NIRS)
    Isao Nambu
    ATR Computational Neuroscience Laboratories, Kyoto, Japan
    Neuroimage 47:628-37. 2009
  8. pmc Finger vein recognition using local line binary pattern
    Bakhtiar Affendi Rosdi
    Intelligent Biometric Group, School of Electrical and Electronic Engineering, USM Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Seberang Perai Selatan, Pulau Pinang, Malaysia
    Sensors (Basel) 11:11357-71. 2011
  9. pmc Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratio
    Jack van Honk
    Department of Experimental Psychology, Utrecht University, 3584 CS, Utrecht The Netherlands
    Proc Natl Acad Sci U S A 108:3448-52. 2011
  10. ncbi Second to fourth digit ratio: ethnic differences and family size in English, Indian and South African populations
    J T Manning
    School of Biological Sciences, The University of Liverpool, Liverpool, UK
    Ann Hum Biol 30:579-88. 2003

Research Grants

  1. UNDERSTANDING VIBRATION INJURY
    Danny A Riley; Fiscal Year: 2013
  2. Arsenic co-carcinogenesis with UVR: nitrosation and oxidation of target proteins
    Ke Jian Liu; Fiscal Year: 2013
  3. Transcriptional regulation of proteinuria
    SUMANT SINGH CHUGH; Fiscal Year: 2011
  4. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2013
  5. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2012
  6. Prostate cancer prevention by selenium supplementation
    Rayudu Gopalakrishna; Fiscal Year: 2012
  7. The structural role of ING proteins in chromatin remodeling.
    KAREN CHAMPAGNE GLASS; Fiscal Year: 2010
  8. GENETIC AND MOLECULAR ANALYSIS OF YEAST DNA REPLICATION
    Robert A Sclafani; Fiscal Year: 2012
  9. MOLECULAR GENETICS OF HSV DNA POLYMERASE GENE
    James M Hogle; Fiscal Year: 2013
  10. A New Device for Rapid Measurement of Touch Sensation in neuropathy
    Donald A Simone; Fiscal Year: 2010

Detail Information

Publications291 found, 100 shown here

  1. ncbi Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia
    Piero O Bonetti
    Center for Coronary Physiology and Imaging, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 44:2137-41. 2004
    ..We investigated the value of reactive hyperemia peripheral arterial tonometry (RH-PAT) as a noninvasive tool to identify individuals with coronary microvascular endothelial dysfunction...
  2. ncbi Decoupling the cortical power spectrum reveals real-time representation of individual finger movements in humans
    K J Miller
    Department of Physics, Seattle Children s Research Institute and Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 29:3132-7. 2009
    ..This broad-spectral change exhibited spatially discrete representation for individual fingers and reproduced the temporal movement trajectories of different individual fingers.
  3. ncbi Coding and use of tactile signals from the fingertips in object manipulation tasks
    Roland S Johansson
    Physiology Section, Department of Integrative Medical Biology, Umea University, SE 901 87 Umea, Sweden
    Nat Rev Neurosci 10:345-59. 2009
    ..Analysis of signals in tactile afferent neurons and central processes in humans reveals how contact events are encoded and used to monitor and update task performance...
  4. ncbi Integration of sensory and motor representations of single fingers in the human cerebellum
    Tobias Wiestler
    Institute of Cognitive Neuroscience, University College London, London, United Kingdom
    J Neurophysiol 105:3042-53. 2011
    ..In the present study we investigated the relationship between these two maps for the representation of single fingers. Participants made isometric key presses with individual fingers or received vibratory tactile stimulation to the ..
  5. pmc Developmental basis of sexually dimorphic digit ratios
    Zhengui Zheng
    Howard Hughes Medical Institute and Department of Molecular Genetics and Microbiology and Department of Biology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 108:16289-94. 2011
    ..Our results also suggest that the 2D:4D ratio can serve as an indicator of disrupted endocrine signaling during early development, which may aid in the identification of fetal origins of adult diseases...
  6. ncbi 2nd to 4th digit ratios, fetal testosterone and estradiol
    S Lutchmaya
    Developmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
    Early Hum Dev 77:23-8. 2004
    ..However, there are no studies which show direct relationships between fetal testosterone (FT), fetal estradiol (FE) and 2D:4D...
  7. ncbi Single-trial reconstruction of finger-pinch forces from human motor-cortical activation measured by near-infrared spectroscopy (NIRS)
    Isao Nambu
    ATR Computational Neuroscience Laboratories, Kyoto, Japan
    Neuroimage 47:628-37. 2009
    ..These data demonstrate the potential for reconstructing different levels of external loads (forces) from those of the internal loads (activation) in the human brain using NIRS...
  8. pmc Finger vein recognition using local line binary pattern
    Bakhtiar Affendi Rosdi
    Intelligent Biometric Group, School of Electrical and Electronic Engineering, USM Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Seberang Perai Selatan, Pulau Pinang, Malaysia
    Sensors (Basel) 11:11357-71. 2011
    ..Experimental results show that the proposed method using LLBP has better performance than the previous methods using LBP and local derivative pattern (LDP)...
  9. pmc Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratio
    Jack van Honk
    Department of Experimental Psychology, Utrecht University, 3584 CS, Utrecht The Netherlands
    Proc Natl Acad Sci U S A 108:3448-52. 2011
    ..These findings have importance for our understanding of the psychobiology of human social intelligence...
  10. ncbi Second to fourth digit ratio: ethnic differences and family size in English, Indian and South African populations
    J T Manning
    School of Biological Sciences, The University of Liverpool, Liverpool, UK
    Ann Hum Biol 30:579-88. 2003
    ..Negative associations between male 2D:4D and family size and positive associations between female 2D:4D and family size have been found in some European populations...
  11. ncbi Increased synchronization of cortical oscillatory activities between human supplementary motor and primary sensorimotor areas during voluntary movements
    S Ohara
    Human Brain Research Center, Department of Neurology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo, Kyoto, 606-8507, Japan
    J Neurosci 21:9377-86. 2001
    ..This increase of synchronization between multiple motor areas in the preparation and execution of voluntary movements may reflect the multiregional functional interactions in human motor behavior...
  12. pmc Improvement of sensorimotor functions in old age by passive sensory stimulation
    Tobias Kalisch
    Department of Theoretical Biology, Institute for Neuroinformatics, Ruhr University Bochum, Bochum, Germany
    Clin Interv Aging 3:673-90. 2008
    ..Further optimizing of the stimulation protocol can be assumed to strengthen both the range and durability of its efficacy...
  13. ncbi A functional MRI study of subjects recovered from hemiparetic stroke
    S C Cramer
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Stroke 28:2518-27. 1997
    ..We used functional magnetic resonance imaging to compare brain activations in normal controls and subjects who recovered from hemiparetic stroke...
  14. ncbi Second to fourth digit length ratio (2D:4D) and adult sex hormone levels: new data and a meta-analytic review
    Johannes Hönekopp
    Technische Universitat Chemnitz, Institut fur Psychologie, Wilhelm Raabe Str 43, D 09120 Chemnitz, Germany
    Psychoneuroendocrinology 32:313-21. 2007
    ..The findings from this current study add to the growing body of evidence demonstrating that 2D:4D is a suitable tool to study the effects of prenatal androgenization on human behavior and cognition...
  15. pmc Second-to-fourth digit ratio predicts success among high-frequency financial traders
    John M Coates
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 106:623-8. 2009
    ..The success and longevity of traders exposed to high levels of prenatal androgens further suggests that financial markets may select for biological traits rather than rational expectations...
  16. ncbi TMS of the occipital cortex induces tactile sensations in the fingers of blind Braille readers
    M Ptito
    Chaire Harland Sanders en sciences de la vision, Ecole d Optometrie, Universite de Montreal, Montreal, Canada
    Exp Brain Res 184:193-200. 2008
    ..phosphenes following occipital cortex stimulation, some of the blind subjects reported tactile sensations in the fingers that were somatotopically organized onto the visual cortex...
  17. ncbi Suppression of the non-dominant motor cortex during bimanual symmetric finger movement: a functional magnetic resonance imaging study
    Y Aramaki
    National Institute for Physiological Sciences, 38 Nishigo naka, Myodaiji, Okazaki, Aichi 444 8585, Japan
    Neuroscience 141:2147-53. 2006
    ..subjects completed four conditions: sequential finger tapping using the right and left index and middle fingers, bimanual mirror and parallel finger tapping...
  18. ncbi Post-movement beta rebound is generated in motor cortex: evidence from neuromagnetic recordings
    Michael T Jurkiewicz
    Neuromagnetic Imaging Laboratory, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Neuroimage 32:1281-9. 2006
    ....
  19. ncbi A new form of autosomal dominant limb-girdle muscular dystrophy (LGMD1G) with progressive fingers and toes flexion limitation maps to chromosome 4p21
    Alessandra Starling
    Human Genome Research Center, Department of Biology, University of Sao Paulo, Sao Paulo, Brazil
    Eur J Hum Genet 12:1033-40. 2004
    ..loci in a Brazilian-Caucasian family with 12 patients affected by AD late-onset LGMD associated with progressive fingers and toes flexion limitation...
  20. ncbi Discharges in human muscle receptor afferents during block grasping
    Michael Dimitriou
    Physiology Section, Department of Integrative Medical Biology, Umea University, S 901 87 Umea, Sweden
    J Neurosci 28:12632-42. 2008
    ..We therefore let subjects use their thumb and fingers to grasp blocks presented to them while we recorded muscle afferents from the thumb and finger extensor muscles ..
  21. ncbi Hand function: peripheral and central constraints on performance
    Marc H Schieber
    Department of Neurology, University of Rochester Medical Center, 601 Elmwood Ave, Box 673, Rochester, NY 14642, USA
    J Appl Physiol (1985) 96:2293-300. 2004
    ..Experimental evidence indicates that the simultaneous motion and force of the fingers are characterized by coordination patterns that reduce the number of independent degrees of freedom to be ..
  22. ncbi Timing of muscle activation in a hand movement sequence
    Mary D Klein Breteler
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Cereb Cortex 17:803-15. 2007
    ..The results suggest that hand movements may be generated by activity waves unfolding in time. Because finger muscles are under relatively direct cortical control, this suggests a specific form of cortical pattern generation...
  23. ncbi Online myoelectric control of a dexterous hand prosthesis by transradial amputees
    Christian Cipriani
    The BioRobotics Institute formerly ARTS and CRIM Labs, Scuola Superiore Sant Anna, 56025 Pontedera, Italy
    IEEE Trans Neural Syst Rehabil Eng 19:260-70. 2011
    ..These results are encouraging for the development of noninvasive EMG interfaces for the control of dexterous prostheses...
  24. ncbi Grip force regulation during pinch grip lifts under somatosensory guidance: comparison between people with stroke and healthy controls
    Jannette M Blennerhassett
    Physiotherapy Department, Austin Health Royal Talbot Rehabilitation Centre, Kew, Australia
    Arch Phys Med Rehabil 87:418-29. 2006
    ..To compare the timing and grip force application in a pinch grip task performed under somatosensory guidance in stroke and matched controls and to identify characteristics of impaired grip force regulation after stroke...
  25. ncbi Second to fourth digit ratio and cooperative behavior
    Kobe Millet
    Department of Marketing, Katholieke Universiteit Leuven, Naamsestraat 69, 3000 Leuven, Belgium
    Biol Psychol 71:111-5. 2006
    ..These findings suggest that: (1) there might be a high and a low testosterone strategy to gain status and (2) the high testosterone strategy is characterized by a preference for normative behavior...
  26. pmc Proprioceptive signals contribute to the sense of body ownership
    Lee D Walsh
    Neuroscience Research Australia, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 589:3009-21. 2011
    ..It seems that the congruence of sensory stimuli ismore important to establish body ownership than the presence of multiple sensory signals...
  27. ncbi Partial reconstruction of muscle activity from a pruned network of diverse motor cortex neurons
    Marc H Schieber
    Department of Neurology, Neurobiology and Anatomy, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Neurophysiol 97:70-82. 2007
    ....
  28. ncbi Beta-range EEG-EMG coherence with isometric compensation for increasing modulated low-level forces
    Vihren Chakarov
    Neurological Clinic, University Freiburg, Freiburg, Germany
    J Neurophysiol 102:1115-20. 2009
    ..This finding re-enforces the importance of the beta-range EEG-EMG coherence in sensorimotor integration...
  29. pmc Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood
    David C Muller
    Cancer Epidemiology Centre, The Cancer Council of Victoria, Melbourne, Australia
    Reprod Biol Endocrinol 9:57. 2011
    ..The objective of this study was to examine whether circulating concentrations of sex hormones and SHBG measured in adulthood was associated with 2D:4D...
  30. ncbi Centrifugal regulation of human cortical responses to a task-relevant somatosensory signal triggering voluntary movement
    Tetsuo Kida
    Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    Neuroimage 32:1355-64. 2006
    ..The present findings indicate a difference in function between the SI and SII in somatosensory-motor regulation...
  31. pmc The effect of bilateral isometric forces in different directions on motor cortical function in humans
    Juliette A Yedimenko
    CNBC Systems Neuroscience Institute, Department of Physical Medicine and Rehabilitation, 3501 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurophysiol 104:2922-31. 2010
    ..These findings suggest that during generation of bimanual isometric forces the M1 is driven by "extrinsic" parameters related to the hand action...
  32. ncbi Separating deceptive and orienting components in a Concealed Information Test
    Wolfgang Ambach
    Institute for Frontier Areas of Psychology and Mental Health, Freiburg, Germany
    Int J Psychophysiol 70:95-104. 2008
    ..The findings further support the notion that psychophysiological measures elicited by a modified CIT may reflect different mental processes involved in orienting and deception...
  33. ncbi Motor command for precision grip in the macaque monkey can be mediated by spinal interneurons
    B Alstermark
    Department of Integrative Medical Biology, Section of Physiology, Umea University, Umea, Sweden
    J Neurophysiol 106:122-6. 2011
    ..The precision grip could be performed within the first 15 days after a CST lesion in C4/C5 but not in C2. We conclude that C3-C4 propriospinal interneurons also can carry the command for precision grip...
  34. ncbi The brain's fingers and hands
    Patrick Haggard
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, Alexandra House, London, UK
    Exp Brain Res 172:94-102. 2006
    ..fingertips, with the hands in one of two postures: either the right hand was vertically above the left, or the fingers of both hands were interwoven...
  35. ncbi Tactile spatial resolution in blind braille readers
    R W Van Boven
    Department of Neurology, Northwestern University Medical School, Chicago, IL, USA
    Neurology 54:2230-6. 2000
    ..To determine if blind people have heightened tactile spatial acuity...
  36. ncbi Noise-enhanced vibrotactile sensitivity in older adults, patients with stroke, and patients with diabetic neuropathy
    Wen Liu
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Arch Phys Med Rehabil 83:171-6. 2002
    ..To test the hypothesis that vibrotactile detection thresholds in older adults, patients with stroke, and patients with diabetic neuropathy can be significantly reduced with the introduction of mechanical noise...
  37. ncbi Tactile acuity is enhanced in blindness
    Daniel Goldreich
    Department of Occupational Therapy, Rangos School of Health Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    J Neurosci 23:3439-45. 2003
    ..The results suggest that crossmodal plasticity may underlie tactile acuity enhancement in blindness...
  38. ncbi Dynamic lumped element response of the human fingerpad
    D T Pawluk
    Harvard University, Division of Engineering and Applied Sciences, Cambridge, MA 02138, USA
    J Biomech Eng 121:178-83. 1999
    ..4 s) plus a constant. The model was confirmed with data from sinusoidal displacement trajectories...
  39. ncbi On somatotopic representation centers for finger movements in human primary motor cortex and supplementary motor area
    I Indovina
    Laboratory of Functional Neuroimaging, Fondazione Santa Lucia IRCCS, Via Ardeatina 306, 10079 Rome, Italy
    Neuroimage 13:1027-34. 2001
    ..While separations for digit representations occurred, the entire data set provided more support for the concept of distributed, overlapping representations than for a classic homunculus organization for voluntary finger movements...
  40. ncbi The role of fingerprints in the coding of tactile information probed with a biomimetic sensor
    J Scheibert
    Laboratoire de Physique Statistique de l Ecole Normale Superieure, CNRS UMR 8550, Associé aux Universités Paris 6 et Paris 7, 24 rue Lhomond, 75231 Paris Cedex 05, France
    Science 323:1503-6. 2009
    ..Thus, fingerprints may perform spectral selection and amplification of tactile information that facilitate its processing by specific mechanoreceptors...
  41. ncbi Second to fourth digit ratio, body mass index, waist-to-hip ratio, and waist-to-chest ratio: their relationships in heterosexual men and women
    B Fink
    Ludwig Boltzmann Institute of Urban Ethology, University of Vienna, Austria
    Ann Hum Biol 30:728-38. 2003
    ....
  42. pmc A subcortical oscillatory network contributes to recovery of hand dexterity after spinal cord injury
    Yukio Nishimura
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Brain 132:709-21. 2009
    ..We propose that a subcortical oscillator commonly recruits hand/arm muscles, via remaining pathways such as reticulospinal and/or propriospinal tracts, independent of cortical oscillation, and contributes to functional recovery...
  43. pmc Decoding flexion of individual fingers using electrocorticographic signals in humans
    J Kubanek
    BCI R and D Program, Wadsworth Center, New York State Department of Health, Albany, NY, USA
    J Neural Eng 6:066001. 2009
    ..these results by demonstrating that it is also possible to decode the time course of the flexion of individual fingers using ECoG signals in humans, and by showing that these flexion time courses are highly specific to the moving ..
  44. ncbi Brain regions controlling nonsynergistic versus synergistic movement of the digits: a functional magnetic resonance imaging study
    H Henrik Ehrsson
    Motor Control Laboratory, Department of Woman and Child Health, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Neurosci 22:5074-80. 2002
    ..A task in which flexion of the thumb is accompanied by extension of the fingers and vice versa, i.e...
  45. ncbi Coarticulation in fluent fingerspelling
    Thomas E Jerde
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 23:2383-93. 2003
    ..The proximal interphalangeal (PIP) joints of the index and middle fingers tended to show dissimilation, whereas at the same time (i.e...
  46. ncbi Finger interaction during accurate multi-finger force production tasks in young and elderly persons
    Minoru Shinohara
    Department of Integrative Physiology, University of Colorado, CO 80309, Boulder, USA
    Exp Brain Res 156:282-92. 2004
    ..of finger interaction during maximal force production (MVC) tasks are accompanied by changed coordination of fingers in multi-finger accurate force production tasks...
  47. ncbi Differential activation in somatosensory cortex for different discrimination tasks
    C Braun
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, D 72074 Tubingen, Germany
    J Neurosci 20:446-50. 2000
    ..EEG revealed that, when subjects received passive tactile stimulation of D1 or D5, the representations of the fingers in primary somatosensory cortex were closer together after training than before...
  48. ncbi Digit ratio (2D:4D) and physical fitness in males and females: Evidence for effects of prenatal androgens on sexually selected traits
    Johannes Hönekopp
    Department of Psychology, Technische Universitat Chemnitz, Germany
    Horm Behav 49:545-9. 2006
    ..Thus, 2D:4D in males may be a negative correlate of frequent exercise which then relates to achievement in sports and athletics...
  49. ncbi Perception of the consequences of self-action is temporally tuned and event driven
    Paul M Bays
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom
    Curr Biol 15:1125-8. 2005
    ..When a motor generated a tap on the left finger synchronously with the right tap, simulating contact between the fingers, the perception of force in the left finger was attenuated compared to the same tap experienced during rest...
  50. pmc Anticipatory planning and control of grasp positions and forces for dexterous two-digit manipulation
    Qiushi Fu
    Department of Kinesiology, Arizona State University, Tempe, Arizona 85287 0404, USA
    J Neurosci 30:9117-26. 2010
    ..These results are discussed in the context of motor equivalence and sensorimotor integration of grasp kinematics and kinetics...
  51. ncbi Heritability of the second to fourth digit ratio (2d:4d): A twin study
    Simon N Paul
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, United Kingdom
    Twin Res Hum Genet 9:215-9. 2006
    ..However the current study design does not preclude the possibility of confounding between heritability estimates and unobserved prenatal effects...
  52. ncbi Having a body versus moving your body: How agency structures body-ownership
    Manos Tsakiris
    Department of Psychology, Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Conscious Cogn 15:423-32. 2006
    ..However, the distribution of the RHI across stimulated and non-stimulated fingers depended on the kind of stimulation...
  53. ncbi Patterns of hand motion during grasping and the influence of sensory guidance
    Marco Santello
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:1426-35. 2002
    ..on the kinematics, and the effect of the physical presence of the object became manifest primarily after the fingers had contacted the object. Two principal components accounted for >75% of the variance...
  54. ncbi Early onset of post-movement beta electroencephalogram synchronization in the supplementary motor area during self-paced finger movement in man
    G Pfurtscheller
    Department of Medical Informatics, Institute of Biomedical Engineering, University of Technology Graz, Inffeldgasse 16a, A 8010, Graz, Austria
    Neurosci Lett 339:111-4. 2003
    ..This assumed resetting or inhibitory process within the SMA precedes that of the networks within the primary motor hand area...
  55. ncbi Effector-independent representations of simple and complex imagined finger movements: a combined fMRI and TMS study
    J P Kuhtz-Buschbeck
    Institute of Physiology, Christian Albrechts Universitat, Olshausenstr 40, D 24098 Kiel, Germany
    Eur J Neurosci 18:3375-87. 2003
    ..The effector-independent activation of left premotor areas was particularly evident in the simple motor imagery task and suggests a left hemispherical dominance for kinesthetic movement representations in right-handed subjects...
  56. ncbi Keeping with the beat: movement trajectories contribute to movement timing
    Ramesh Balasubramaniam
    Behavioural Brain Sciences Centre, School of Psychology, University of Birmingham, Edgbaston, B15 2TT, UK
    Exp Brain Res 159:129-34. 2004
    ..We suggest that movement asymmetry in repetitive timing tasks helps satisfy requirements of precision and accuracy relative to a target event...
  57. pmc Differential effects of synchronous and asynchronous multifinger coactivation on human tactile performance
    Tobias Kalisch
    Department of Theoretical Biology, Institute for Neuroinformatics, Ruhr University Bochum, D 44780 Bochum Germany
    BMC Neurosci 8:58. 2007
    ..Here we investigated the effect of different types of multifinger CA on the tactile performance of each finger of the right hand...
  58. pmc Dissociation of the pathways mediating ipsilateral and contralateral motor-evoked potentials in human hand and arm muscles
    U Ziemann
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
    J Physiol 518:895-906. 1999
    ..Other pathways, such as branching of corticomotoneuronal axons, a transcallosal projection or a slow-conducting monosynaptic ipsilateral pathway are very unlikely or can be excluded...
  59. ncbi Utility of second derivative of the finger photoplethysmogram for the estimation of the risk of coronary heart disease in the general population
    Toshiaki Otsuka
    Environmental Medicine, Graduate School of Medicine, Tama Nagayama Hospital, Nippon Medical School, Tokyo, Japan
    Circ J 70:304-10. 2006
    ....
  60. ncbi Quantification of myelinated endings and mechanoreceptors in human digital skin
    Maria Nolano
    Salvatore Maugeri Foundation, IRCCS, Center of Telese Terme, Italy
    Ann Neurol 54:197-205. 2003
    ..In addition to diagnostic applications, this technique allows clarification of the mode of termination of Abeta fibers and their relationship with mechanoreceptors, leading to relevant electrophysiological speculations...
  61. ncbi Covert respiration measures for the detection of concealed information
    Eitan Elaad
    Ariel University Center, Ariel, Israel
    Biol Psychol 77:284-91. 2008
    ..One of the covert measures produced detection efficiency that was similar to that of the standard respiration and finger pulse measures, but less than the electrodermal measure...
  62. ncbi Integration of hand and finger location in external spatial coordinates for tactile localization
    Tobias Heed
    Biological Psychology and Neuropsychology, University of Hamburg, Von Melle Park 11, 20146 Hamburg, Germany
    J Exp Psychol Hum Percept Perform 38:386-401. 2012
    ..Whereas remapping seems to occur automatically for the hands and feet, the fingers may constitute an exception in that some studies have implied purely somatotopic coding of touch to the fingers...
  63. ncbi The presence of aggression cues inverts the relation between digit ratio (2D:4D) and prosocial behaviour in a dictator game
    Kobe Millet
    Department of Marketing and Organization Studies, Katholieke Universiteit Leuven, Leuven, Belgium
    Br J Psychol 100:151-62. 2009
    Digit ratio (2D:4D) is a sexually dimorphic trait. Men have relatively shorter index (2D) compared to ring (4D) fingers than women. More masculine ratios are thought to be influenced by higher prenatal testosterone levels...
  64. ncbi The relationship between the photoplethysmographic waveform and systemic vascular resistance
    Aymen A Awad
    Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208051, New Haven, CT 06520 8051, USA
    J Clin Monit Comput 21:365-72. 2007
    ..The objective of this study was to determine the relationship between systemic vascular resistance (SVR), finger & ear photoplethysmographic measurements in 14 adult patients undergoing coronary artery bypass grafting (CABG)...
  65. ncbi Sensorimotor integration to cutaneous afferents in humans: the effect of the size of the receptive field
    Stefano Tamburin
    Department of Neurological Sciences and Vision, Section of Neurological Rehabilitation, University of Verona, Verona, Italy
    Exp Brain Res 167:362-9. 2005
    ..second (D2) and third finger (D3), the right second and third finger together (D23) and the right first three fingers together (D123) on the amplitude of motor evoked potentials (MEPs) to TMS in hand and forearm muscles...
  66. ncbi Analysis of finger-tapping movement
    Akos Jobbágy
    Department of Measurement and Information Sytems, Budapest University of Technology and Economics, P O B 91, 1521 Budapest, Hungary
    J Neurosci Methods 141:29-39. 2005
    ..32 healthy subjects (148 recordings) and 10 Parkinsonian patients (25 recordings) were tested. The tracking of fingers during the whole movement increased the level of information obtained from the finger-tapping test compared to ..
  67. ncbi Digit ratio (2D:4D) and performance in elite rugby players
    M Bennett
    Ospreys Rugby Union Club, Swansea
    J Sports Sci 28:1415-21. 2010
    ..Low right 2D:4D and low right - left 2D:4D difference were significantly linked with large numbers of tries. We conclude that low right 2D:4D and low right - left 2D:4D difference are predictors of high rugby performance...
  68. ncbi Finger length ratios (2D:4D) in anthropoids implicate reduced prenatal androgens in social bonding
    Emma Nelson
    School of Archaeology, Classics and Egyptology, University of Liverpool, Liverpool L69 3GS, United Kingdom
    Am J Phys Anthropol 141:395-405. 2010
    ..Human ratios are intermediate between pair-bonded and more promiscuous hominoids. We propose that PAE may be involved in promoting species characteristic social behavior in anthropoids...
  69. ncbi Digit ratio and hand-grip strength in German and Mizos men: cross-cultural evidence for an organizing effect of prenatal testosterone on strength
    Bernhard Fink
    Department of Sociobiology Anthropology, University of Gottingen, Gottingen, D 37073, Germany
    Am J Hum Biol 18:776-82. 2006
    ..Measures of grip strength correlate strongly with strength in other muscle groups, so we conclude that PT may have an early organizing effect on strength in men, and this is likely to be widespread in human groups...
  70. ncbi A new algorithm for distorted fingerprints matching based on normalized fuzzy similarity measure
    Xinjian Chen
    Center for Biometrics and Security Research, Key Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China
    IEEE Trans Image Process 15:767-76. 2006
    ..The algorithm gives considerably higher matching scores compared to conventional matching algorithms for the deformed fingerprints...
  71. ncbi Sporting achievement: what is the contribution of digit ratio?
    Nicholas Tester
    Durham University, UK
    J Pers 75:663-77. 2007
    ..We suggest that physiological as well as psychological factors may be an important avenue for future study...
  72. ncbi Multiresolution imaging of MEG cortical sources using an explicit piecewise model
    Benoit Cottereau
    Cognitive Neuroscience and Brain Imaging Laboratory, CNRS UPR 640 LENA, University Pierre and Marie Curie Paris 6, Hopital de la Salpetriere, Paris, France
    Neuroimage 38:439-51. 2007
    ..An experimental evaluation was conducted with MEG data from a somatotopic paradigm. Results show that MiMS is an efficient image model selection technique with robust performances at realistic noise levels...
  73. pmc Finger vein recognition based on a personalized best bit map
    Gongping Yang
    School of Computer Science and Technology, Shandong University, Jinan 250101, China
    Sensors (Basel) 12:1738-57. 2012
    ..Experimental results show that PBBM achieves not only better performance, but also high robustness and reliability. In addition, PBBM can be used as a general framework for binary pattern based recognition...
  74. pmc Receptive field properties of the macaque second somatosensory cortex: representation of orientation on different finger pads
    Paul J Fitzgerald
    Zanvyl Krieger Mind Brain Institute, Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 26:6473-84. 2006
    ..orientations on their tuned pads, which can be interpreted as evidence for integration of information across fingers or as a form of positional invariance...
  75. ncbi Altered pattern of motor cortical activation-inhibition during voluntary movements in Tourette syndrome
    Stephanie Franzkowiak
    Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Duesseldorf, Germany
    Mov Disord 25:1960-6. 2010
    ..The stronger this inhibition is, the better symptoms appear to be controlled...
  76. ncbi High fetal testosterone and sexually dimorphic cerebral networks in females
    C Ciumas
    Stockholm Brain Institute and Department of Clinical Neuroscience, SE 17177 Stockholm, Sweden
    Cereb Cortex 19:1167-74. 2009
    ..Thus, we find no evidence for masculinization of the limbic circuits in women with high fetal testosterone...
  77. ncbi High gamma oscillations of sensorimotor cortex during unilateral movement in the developing brain: a MEG study
    Xiaolin Huo
    Department of Neurology, MLC 2015, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Brain Topogr 23:375-84. 2011
    ..In addition, the interesting finding of the ipsilateral high-gamma neuromagnetic activities opens a new window for us to understand the developmental changes of the hemispherical functional lateralization in the motor system...
  78. ncbi Effects of attention and precision of exerted force on beta range EEG-EMG synchronization during a maintained motor contraction task
    Rumyana Kristeva-Feige
    Neurological Clinic, Albert Ludwigs University, Breisacherstrasse 64, 79106 Freiburg, Germany
    Clin Neurophysiol 113:124-31. 2002
    ..The present study was aimed at investigating the effect of attention and precision level of exerted force on beta range EEG-EMG synchronization...
  79. pmc Sexual dimorphism in the prenatal digit ratio (2D:4D)
    Frietson Galis
    Institute of Biology, Leiden University, PO Box 9516, 2300 RA Leiden, The Netherlands
    Arch Sex Behav 39:57-62. 2010
    ..Therefore, the sexual dimorphism is probably determined by prenatal as well as by postnatal developmental processes...
  80. pmc Gender differences in financial risk aversion and career choices are affected by testosterone
    Paola Sapienza
    Kellogg School of Management, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:15268-73. 2009
    ..These results suggest that testosterone has both organizational and activational effects on risk-sensitive financial decisions and long-term career choices...
  81. pmc Maximal voluntary fingertip force production is not limited by movement speed in combined motion and force tasks
    Kevin G Keenan
    Department of Biomedical Engineering and Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 29:8784-9. 2009
    Numerous studies of limbs and fingers propose that force-velocity properties of muscle limit maximal voluntary force production during anisometric tasks, i.e., when muscles are shortening or lengthening...
  82. ncbi Body posture affects tactile discrimination and identification of fingers and hands
    Martin Riemer
    Otto Selz Institute for Applied Psychology, Mannheim Centre for Work and Health, University of Mannheim, 68131, Mannheim, Germany
    Exp Brain Res 206:47-57. 2010
    It is an unresolved question whether the posture of single fingers relative to each other is represented in the brain within an external frame of reference...
  83. ncbi Coordinated force production in multi-finger tasks: finger interaction and neural network modeling
    V M Zatsiorsky
    Department of Kinesiology, Pennsylvania State University, University Park 16802, USA
    Biol Cybern 79:139-50. 1998
    During maximal voluntary contraction (MVC) with several fingers, the following three phenomena are observed: (1) the total force produced by all the involved fingers is shared among the fingers in a specific manner (sharing); (2) the ..
  84. ncbi Meta-analysis of digit ratio 2D:4D shows greater sex difference in the right hand
    Johannes Hönekopp
    Department of Psychology, Northumbria University, Newcastle upon Tyne NE1 8ST, United Kingdom
    Am J Hum Biol 22:619-30. 2010
    ..Second, to infer the loss of reliability observed in 2D:4D based on self-measured finger lengths...
  85. pmc Simultaneous measurements of kinematics and fMRI: compatibility assessment and case report on recovery evaluation of one stroke patient
    Claudia Casellato
    Politecnico di Milano, Bioengineering Dept, NearLab, Piazza L, Da Vinci 32, 20133, Milano, Italy
    J Neuroeng Rehabil 7:49. 2010
    ..Therefore, we have explored a new set-up combining fMRI with an optoelectronic motion capture system, which provides a multi-parameter quantification of the performed motor task...
  86. ncbi Large index-fingertip forces are produced by subject-independent patterns of muscle excitation
    F J Valero-Cuevas
    Rehabilitation Research and Development Center, Veterans Affairs Palo Alto Health Care System, CA 94304 1200, USA
    J Biomech 31:693-703. 1998
    ....
  87. pmc Somatosensory activation of two fingers can be discriminated with ultrahigh-density diffuse optical tomography
    Christina Habermehl
    Berlin NeuroImaging Center, Charite Universitatsmedizin, Chariteplatz 1, 10117 Berlin, Germany
    Neuroimage 59:3201-11. 2012
    ..Distinct activation patterns for both fingers correlated well with the expected neuroanatomy in five of eight subjects...
  88. pmc Finger inter-dependence: linking the kinetic and kinematic variables
    Sun Wook Kim
    Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, United States
    Hum Mov Sci 27:408-22. 2008
    We studied the dependence between voluntary motion of a finger and pressing forces produced by the tips of other fingers of the hand...
  89. ncbi Second to fourth digit ratios, male genital development and reproductive health: a clinical study among fertile men and testis cancer patients
    J Auger
    Service d Histologie Embryologie, Biologie de la Reproduction CECOS, Hopital Cochin, Paris, France
    Int J Androl 34:e49-58. 2011
    ....
  90. ncbi Tactile spatial acuity enhancement in blindness: evidence for experience-dependent mechanisms
    Michael Wong
    McMaster Integrative Neuroscience Discovery and Study, McMaster University, Hamilton, Ontario, L8S 4K1 Canada
    J Neurosci 31:7028-37. 2011
    ..tactile spatial acuity of 28 profoundly blind and 55 normally sighted humans on the index, middle, and ring fingers of each hand, and on the lips...
  91. ncbi Fetal development of the hand, digits and digit ratio (2D:4D)
    Mehmet Ali Malas
    Medical Faculty, Department of Anatomy, Suleyman Demirel University, 32260 Isparta, Turkey
    Early Hum Dev 82:469-75. 2006
    ..The purpose of this study was to investigate growth patterns in human hands, digits and digit ratio (2D:4D) during the fetal period...
  92. pmc Minireview: Organizational hypothesis: instances of the fingerpost
    S Marc Breedlove
    Neuroscience Program and Department of Psychology, 108 Giltner Hall, Michigan State University, East Lansing, Michigan 48824 1101, USA
    Endocrinology 151:4116-22. 2010
    ..Thus digit ratios offer a valid test of the organizational hypothesis that androgens act early in life to masculinize various human behaviors...
  93. ncbi The role of somatotopy and body posture in the integration of texture across the fingers
    Roberta D Roberts
    Behavioural Brain Sciences Centre, University of Birmingham, Birmingham, UK
    Psychol Sci 21:476-83. 2010
    In two experiments, we investigated the automatic integration of touch across the fingers. Participants made judgments about the roughness of sequences of textures presented to one finger while simultaneously feeling textures of varying ..
  94. ncbi A randomized controlled pilot study to obtain the best estimate of the size of the effect of a thermoplastic resting splint on spasticity in the stroke-affected wrist and fingers
    J L Sheehan
    School of Occupational Therapy, La Trobe University and The Royal Melbourne Hospital, Royal Park Campus, Victoria, Australia
    Clin Rehabil 20:1032-7. 2006
    ..To obtain the best estimate of the size of the effect of a thermoplastic resting splint on spasticity in the stroke-affected upper limb...
  95. ncbi Tactile feedback and timing accuracy in piano performance
    Werner Goebl
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada
    Exp Brain Res 186:471-9. 2008
    ..These findings suggest that sensory information available at finger-key contact enhances the timing accuracy of finger movements in piano performance...
  96. ncbi On the relations between affordance and representation of the agent's effector
    Filippo Barbieri
    Dipartimento di Neuroscienze, Universita di Parma, Via Volturno 39, 43100 Parma, Italy
    Exp Brain Res 180:421-33. 2007
    ..Finally, our data confirm the influence of semantics on the control of arm movements, though less strong than that due to visual input...
  97. ncbi Grasp with hand and mouth: a kinematic study on healthy subjects
    M Gentilucci
    Istituto di Fisiologia Umana, I 43100 Parma, Italy
    J Neurophysiol 86:1685-99. 2001
    ..size while opening the mouth (experiments 1 and 3), or extending the other forearm (experiment 4), or the fingers of the other hand (experiment 5)...
  98. ncbi Bio-inspired sensorization of a biomechatronic robot hand for the grasp-and-lift task
    B B Edin
    Physiology Section, Department of Integrative Medical Biology, Umea University, SE 901 87 Umea, Sweden
    Brain Res Bull 75:785-95. 2008
    ..To accomplish this we have developed (1) a contact sensor that can be applied to the surface of the robotic fingers and that show a sensitivity to indentation and a spatial resolution comparable to that of the human glabrous skin,..
  99. ncbi Touch and temporal behavior of grand piano actions
    Werner Goebl
    Austrian Research Institute for Artificial Intelligence OFAI, Freyung 6 6, 1010 Vienna, Austria
    J Acoust Soc Am 118:1154-65. 2005
    ..Constant temporal behavior over type of touch and low compression properties of the parts of the action (reflected in key bottom contact times) were hypothesized to be indicators for instrumental quality...
  100. pmc Second to fourth digit ratio, testosterone and perceived male dominance
    Nick Neave
    Human Cognitive Neuroscience Unit, School of Psychology and Sport Sciences, Northumberland Building, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
    Proc Biol Sci 270:2167-72. 2003
    ..We conclude that facial dominance and masculinity reflect a male's perceived status rather than his physical attraction to women...
  101. ncbi Optimal feedback control as a theory of motor coordination
    Emanuel Todorov
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0515, USA
    Nat Neurosci 5:1226-35. 2002
    ..We present experimental results from a range of motor tasks to support this theory...

Research Grants74

  1. UNDERSTANDING VIBRATION INJURY
    Danny A Riley; Fiscal Year: 2013
    ..The major nerve and artery pathologies of HAVS are debilitating numbness and reduced blood flow in the fingers. The Approach: Exposing humans to damaging vibration in a research study is unethical so animal model surrogates ..
  2. Arsenic co-carcinogenesis with UVR: nitrosation and oxidation of target proteins
    Ke Jian Liu; Fiscal Year: 2013
    ..Aim 2 will investigate the interaction of arsenic-generated reactive oxygen and nitrogen species with the zinc fingers of XPA and PARP-1 and apply analytical techniques to define specific modifications of the zinc finger domain and ..
  3. Transcriptional regulation of proteinuria
    SUMANT SINGH CHUGH; Fiscal Year: 2011
    ..The goal of this proposal is to understand the role of transcriptional factor Zinc Fingers and Homeoboxes 3 (ZHX3) in the pathogenesis of glomerular disease...
  4. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2013
    ..Another current focus is determining the function of highly conserved PHD fingers in MLL...
  5. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2012
    ..Another current focus is determining the function of highly conserved PHD fingers in MLL...
  6. Prostate cancer prevention by selenium supplementation
    Rayudu Gopalakrishna; Fiscal Year: 2012
    ..their cancer-preventive actions, at least in part, through oxidation of unique cysteine- rich regions and zinc fingers present in protein kinase C (PKC), a known target for a variety of tumor promoters...
  7. The structural role of ING proteins in chromatin remodeling.
    KAREN CHAMPAGNE GLASS; Fiscal Year: 2010
    ..Recently, our group found that the PHD fingers of ING proteins recognize methylated H3K4...
  8. GENETIC AND MOLECULAR ANALYSIS OF YEAST DNA REPLICATION
    Robert A Sclafani; Fiscal Year: 2012
    ..and regulation of the MCM DNA helicase by investigating both the N- terminal and C- terminal [unreadable] (Beta)-fingers and the N-terminal region A domain regulated by DDK...
  9. MOLECULAR GENETICS OF HSV DNA POLYMERASE GENE
    James M Hogle; Fiscal Year: 2013
    ..investigate the roles of structural domains of the catalytic subunits that are N-terminal to the thumb, palm, and fingers domains in terms of enzymatic functions, binding to the base excision repair (BER) enzyme uracil DNA glycosylase (..
  10. A New Device for Rapid Measurement of Touch Sensation in neuropathy
    Donald A Simone; Fiscal Year: 2010
    ..In neuropathy, sensory dysfunction almost always begins in the distal extremities (fingers or toes) where the sensation of touch is diminished or lost...
  11. Recognition of Regulatory and Pathogenic RNA by Muscleblind Zinc Fingers
    PETER EDWIN WRIGHT; Fiscal Year: 2010
    ..The interactions of the human muscleblind zinc fingers with single stranded RNA targets and with double stranded CUG and CCUG repeats will be mapped using NMR and ..
  12. Molecular analysis of CHD4
    Tatiana G Kutateladze; Fiscal Year: 2013
    ..CHD4 contains tandem plant homeodomain (PHD) fingers of unknown function...
  13. STATIC AND DYNAMIC ORGANIZATION OF PRIMATE MOTOR CORTEX
    John P Donoghue; Fiscal Year: 2013
    ..be used to simultaneously record neuronal spiking (192 channels) and measure the actions of the arm, wrist and fingers while monkeys perform tasks in different contexts...
  14. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2010
    ..treating these highly disabled stroke subjects, AMES treatment usually did not restore functional movement at the fingers, wrist, or ankle if the joint was plegic...
  15. Structure and function of the fingers tendinous apparatus
    Francisco J Valero-Cuevas; Fiscal Year: 2013
    ..That is, we will confront the very challenge the nervous system faces by controlling the tendons of cadaveric fingers with an autonomous neuromechatronic system of microprocessors and motors that implements the known motor and ..
  16. Promoter Specific Hypermethylation Sensors for Early Cancer Detection
    Indraneel Ghosh; Fiscal Year: 2011
    ..by methyl-CpG binding domains (MBDs), while the correct promoter sequence will recognized by designed zinc-fingers. Our approach has the potential to provide sensitive turn-on sensors for directly reporting upon CpG methylation ..
  17. A Biomimetic Prehensile Digit for Upper-Limb Prostheses
    BRADLEY D VEATCH; Fiscal Year: 2011
    ..Hand Enterprises'innovative new prehensile digit technology uses synthetic textile fibers to realize modular fingers that are robust, lightweight, and inexpensive...
  18. HITCH: A Study of HPV Transmission in Young Couples
    Eduardo L Franco; Fiscal Year: 2013
    ..determinants for HPV transmission upon exposure;and (5) to characterize HPV infection in the oral tract and fingers and its agreement with genital infection and partner's infection status...
  19. Structural insight into the role of CHD4 PHD fingers.
    CATHERINE ANNE MUSSELMAN; Fiscal Year: 2011
    ..The role of CHD4 in this complex, however, remains unclear. Our preliminary data suggest that two PHD fingers of CHD4 recognize histone H3, with PHD2 specifically recognizing H3K9me3, a novel interaction...
  20. The Role of the Vasculature in the Pathogenesis of Arthritis
    DEAN YAW LI; Fiscal Year: 2013
    ..form the disease has debilitating effects including painful inflammation and destruction of the joints of the fingers, wrists, knees, hips, and vertebral column and leads to reduced life expectancy...
  21. DEVICE FOR PROMOTING SURVIVAL OF CONGESTED TISSUE FLAPS
    John A Russell; Fiscal Year: 2010
    ..Effective salvage of amputated limbs, fingers, breasts, or critical tissues of the head and neck will clearly enhance physical, occupational, and vocational ..
  22. Artificial Hand's Seeing Fingers: A New Device for Ingested Foreign Bodies Remova
    VLADIMIR RUBTSOV; Fiscal Year: 2010
    ..Therefore, physicians involved in these procedures need a tool that can mimic human fingers, which provide maximum articulation...
  23. ATTENTION AND TACTILE PROCESSING IN SOMATOSENSORY CORTEX
    Steven S Hsiao; Fiscal Year: 2013
    ..In these studies the animals'hand and fingers will be passively moved to contact objects of varying size and shape...
  24. PDRemote: Automated Telehealth Diagnostics for Remote Parkinson's Monitoring
    JOSEPH GIUFFRIDA; Fiscal Year: 2013
    ..PD is characterized by tremors of the fingers, hands, head, and neck, bradykinesia (slowed movements), and rigidity of musculature...
  25. Function of PHD Domain Proteins in Chromatin Regulation
    Or P Gozani; Fiscal Year: 2013
    ..This module is present throughout eukaryotic proteomes, and mutations in the PHD fingers of many proteins are associated with cancers, immunodeficiency and mental retardation syndromes, and other ..
  26. Intraflagellar transport mediated regulation of hedgehog signaling
    Bradley K Yoder; Fiscal Year: 2012
    ..of this organelle leads to severe developmental abnormalities including a truncated limb and formation of extra fingers and toes...
  27. NextGen DNA Binding Proteins Based on TAL Domains
    David J Segal; Fiscal Year: 2013
    ..TAL domains appear to be even more flexible in their recognition properties than zinc fingers (ZFs), the engineering of which have had transformative impact in the areas of gene regulation, genome ..
  28. Molecular Mechanisms of Myoblast Fusion
    ELIZABETH HUI CHEN; Fiscal Year: 2013
    ..podosome-like structure (PLS), which invades the opposing fusion partner with multiple protrusive fingers leading to fusion pore formation...
  29. EMG-Based Multi-Joint Control of Dexterous Prosthetic Limbs
    CHRISTOPHER LEE PULLIAM; Fiscal Year: 2012
    ..Since normal human hand function has coordinated, simultaneous movement of the fingers, thumb, and wrist, this sequential control method can be frustratingly slow due to the significant cognitive ..
  30. Molecular Regulation of Mammalian Meiosis
    Kenneth Paigen; Fiscal Year: 2013
    ..an integrated model of its molecular functions;and d) Exploit the exceptional degree of variability in the Zn fingers (ZNF) of PRDM9 to clarify the complex nature of ZNF - DNA interactions, which are so ubiquitous in genomic ..
  31. Developing a Medical Biometric Identification System wit a Secure Database Networ
    Jason W Sohn; Fiscal Year: 2012
    ..A new patient initially will have two fingers scanned (about 1 second each) and is photographed with web camera...
  32. Dissecting the Mechanisms of Cell-Cell Fusion Using A Cell Culture System
    ELIZABETH HUI CHEN; Fiscal Year: 2013
    ..F-actin-enriched podosome-like structure that invades the opposing fusion partner with multiple protrusive fingers, which ultimately leads to fusion pore formation. In addition, studies in the round worm C...
  33. Prediction and Design of Nucleic Acid Recognition by Repeat Proteins
    Philip Bradley; Fiscal Year: 2013
    ..ankyrin, and HEAT repeat proteins have been selected for use in protein-protein interactions, while C2H2 zinc fingers, PUF, and PPR repeats are widely deployed for sequence-specific recognition of nucleic acids...
  34. Control of lymphoid effector programs by the E3 ligase cullin 3
    ALBERT S BENDELAC; Fiscal Year: 2013
    ..their BTB domain in order to induce chromatin modifications at sequence-specific target sites bound by their zinc fingers. PLZF directs the developmental acquisition of innate-like effector properties by microbial lipid-specific NKT ..
  35. Biological functions and mechanisms of action of Ikaros proteins
    Stephen T Smale; Fiscal Year: 2013
    ..approximately 800 C2H2 zinc finger proteins encoded by mammalian genomes, Ikaros contains multiple tandem zinc fingers within its DNA-binding domain...
  36. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian-Smith; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cervical dorsal root injuries that result in the deafferentation of the fingers can severely impair hand function, especially the execution of manual tasks that depend on continuous sensory feedback (..
  37. Cancer Epigenetics Deregulation of Chromatin templated Processes
    Robert G Roeder; Fiscal Year: 2010
    ..Notably, both the H3K4me "writer", MLL, and the "eraser", JARID1, contain several PHD fingers that "read" H3K4me marks, and the dysregulation of either of these enzymes causes blood cancers in humans...
  38. The Bumps, a device for rapid, non invasive quantification of touch sensation
    William R Kennedy; Fiscal Year: 2012
    ..simple, pocket size device, called "the Bumps" that rapidly quantifies the important sensation of touch on the fingers in micrometer ([unreadable]m) units...
  39. Hoogsteen base pairing in human DNA polymerase iota
    Satya Prakash; Fiscal Year: 2010
    ..base pairing in Poll's active site by analyzing the effects that mutational changes in the residues of the fingers and palm domains, that are seen to interact with the templating nt or with the incoming nt in Poll ternary ..
  40. Targeted Reinnervation and Pattern-Recognition Control for Transradial Amputees
    TODD ALAN KUIKEN; Fiscal Year: 2012
    ..of prostheses that have more functions including wrist rotation, wrist flexion/extension and hands with moving fingers and thumbs...
  41. Intra-Oral drug-eluting adhesive film
    Haesun Park; Fiscal Year: 2011
    ..adhesive layer is such that the film will not be removed from the sore surface unless carefully pulled away by fingers. Our preliminary study showed that the films could stay in place until being peeled away by fingers...
  42. Biomimetic Tactile Sensor for Prosthetics
    NICHOLAS WETTELS; Fiscal Year: 2011
    ..has been the absence of sensitive yet robust sensors that can be incorporated into anthropomorphic mechatronic fingers and used in the diverse and often hostile environments in which hands need to function...
  43. The Bumps ad device for rapid non invasive quantification of touch sensation
    William R Kennedy; Fiscal Year: 2013
    ..by applicant): Our proposal describes an elegant device called the Bumps that quantifies touch sensation on the fingers at low micron levels...
  44. Coding of Action by Motor &Premotor Cortial Ensembles
    Nicholas G Hatsopoulos; Fiscal Year: 2013
    ..reaching and prehensile movements are characterized by distinct coordination patterns among the arm, wrist, and fingers and has postulated the existence of coordination mechanisms that temporally couple these segments of the upper ..
  45. Development and Performance Evaluation of a Handheld Noninvasive Glucose Monitor
    REBECCA A BURRELL; Fiscal Year: 2011
    ..development, and bring millions of diabetics a way to monitor their disease without the need to prick their fingers. Under previous SBIR grants and company funds, VivaScan has developed and successfully tested VS175 an advanced ..
  46. Assessment of the Chemical Biology of HNO via New Donors
    Katrina M Miranda; Fiscal Year: 2010
    ..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions.
  47. DNA sequencing using nanopore-nanoelectrode devices for sensing and manipulation
    Marija Drndic; Fiscal Year: 2010
    ..This sensor works just like picking out the knots on a string by running it through one's fingers, except the string is a million times thinner! It will enable major improvements in the understanding, diagnosis, ..
  48. Cortical Control of a Dextrous Prosthetic Hand
    Andrew B Schwartz; Fiscal Year: 2012
    ..behavior is characterized by four components- reach, hand shaping, orientation and the closing of the fingers around the object...
  49. Deep Letter Knowledge for Emerging Literacy Using iPads
    JEANNINE HERRON; Fiscal Year: 2013
    ..Specific Aims: Talking Fingers, Inc...
  50. Pre-motor Neural Circuits for Exploratory Movement
    Fan Wang; Fiscal Year: 2013
    ..Humans use delicate and complex movements of fingers/fingertips to discern the texture, shape and other physical properties of objects, and to manipulate tools...
  51. MITOCHONDRIAL DNA OF NORMAL AND MUTANT TRYPANOSOMES
    Kenneth D Stuart; Fiscal Year: 2013
    ..finger domains to determine if their effect on endonuclease activity and mRNA cleavage;B6, B7 and B8 and their Zn fingers to determine their effects on endonuclease specificity and regulation;and the low abundance B9 and B10 that ..
  52. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2007
    ..g., fingers, wrist, and ankle) rendered completely plegic by the stroke...
  53. Sensory pathways for stimulus detection during behavior
    Manuel A Castro-Alamancos; Fiscal Year: 2013
    ..Animals, including humans, explore the environment using active strategies that involve moving their sensors (fingers, eyes). An excellent example of this type of behavior is active whisking in rodents...
  54. Multi-modal Application for the Perception of Spaces (MAPS)
    Richard J Adams; Fiscal Year: 2013
    ..The tactile display peripheral, similar to ear buds (but worn on two fingers), plugs into the standard USB port on any modern Android tablet;providing independent cues for touch screen ..
  55. Adaptive Smart Controller For Brain-Prosthetic Hand Interface
    SAMUEL THOMAS CLANTON; Fiscal Year: 2010
    ..experiments will be used to characterize controlled features of grasping, such as kinematic coordination of the fingers and measures of manipulability of objects with achieved grasps...
  56. Clinical Demonstration of Implantable Myoelectric Sensors for Prosthesis Control
    RICHARD FERGUS FFRENCH WEIR; Fiscal Year: 2013
    ..Myoelectric Hand Prostheses In Transradial Amputees;Phase 2 - Demonstration of the IMES System and MDOF Controller Coordinating Volitional Movements of The Individual Fingers And Thumb of A Prosthetic Hand In Transradial Amputees.
  57. Electrocorticography signals for human hand prosthetics
    Jeffrey G Ojemann; Fiscal Year: 2013
    ..aim, we will look for control signals reflecting different hand functions, rather than movement of different fingers. For instance, we will examine if pinch and grasp behaviors give more separable high- frequency ECoG signals...
  58. Development of a biomimetic exoskeleton for effective rehabilitation of the hand
    Sang Wook Lee; Fiscal Year: 2013
    ..The proposed device will produce a range of functional hand movements with 20 exotendons, 16 for fingers and 4 for thumbs, which are controlled by 7 motors...
  59. DEVELOPMENT OF AN IMPLANTABLE EMG MICRO-TELEMETER
    DAVID EDELL; Fiscal Year: 2006
    ..For below-elbow amputees, simultaneous control of multiple powered joints (i.e. wrist, thumb, fingers) could be accomplished if multiple sources of high quality control signals were available...
  60. Artificial Hand: A New Device for Ingested Foreign Bodies Removal
    VLADIMIR RUBTSOV; Fiscal Year: 2007
    ..The development of a flexible, safe tool that can, ideally, mimic human fingers (there is nothing more articulating than the human hand) is the dream of physicians involved in these procedures...
  61. Feel-Beyond-Fingers device for the Blind
    PHILIP SCHAEFER; Fiscal Year: 2009
    ..Based on an innovative infrared distance-sensing technology, the proposed Feel-Beyond-Fingers device has several significant advantages that make it unique among solutions for blind users...
  62. Neurological Exams Teaching &Evaluation Using Virtual Patients
    Benjamin Lok; Fiscal Year: 2013
    ..history, a neurological exam (including using an ophthalmoscope and administering tests such as holding up fingers, visual acuity, and asking the patient to project the tongue), and an after-action review of the patient-doctor ..
  63. Nucleotide selectivity and drug resistance by HIV reverse transcriptase
    KENNETH ALLEN JOHNSON; Fiscal Year: 2012
    ..In preliminary data, we show that we can label HIV RT with a fluorophore on the fingers domain in a position that provides a signal to monitor the conformational changes upon nucleotide binding, and we ..
  64. An Outcome Study of Rheumatoid Hand Arthroplasty
    Kevin C Chung; Fiscal Year: 2013
    ..A common deformity is at the metacarpophalangeal joints (MCPJs) to cause ulnar drift and extension lag of the fingers. Because of the paucity of high-level evidence studies for RA hand surgical procedures, we began in 2003 a ..
  65. METALLOENZYME SYNTHESIS, STRUCTURE AND FUNCTION
    William Konigsberg; Fiscal Year: 1999
    ..roles of Zn(II) in 1) zinc metalloenzymes, 2) the eukaryotic transcription factors originally termed zinc fingers, and 3) several proteins involved in nucleic acid replication which contain zinc...
  66. PROTEIN BINDING DOMAINS ON EUKARYOTIC 5S RRNA AND RDNA
    Paul Huber; Fiscal Year: 2000
    ..of adduct formation on the protein will be determined in order to assess the relative importance of the nine fingers for binding to the different nucleic acids and whether the linker sequences that connect the fingers form ..
  67. CASE CROSSOVER STUDY OF OCCUPATIONAL HAND INJURIES
    Murray Mittleman; Fiscal Year: 2000
    ..4 million emergency department visits for occupational upper extremity trauma, 80% of which involved the fingers, hand or wrist...
  68. PROMYELOCYTIC ZINC FINGER GENE
    Jennifer Morris; Fiscal Year: 1999
    ..Recombinant PLZF protein containing the nine C2H2 zinc fingers will be used to affinity select (by gel shift assays or chromatography) DNA binding sites from a degenerate ..
  69. LCP Nerve Cuff with Telemetry for Prosthetic Sensation
    RONALD RISO; Fiscal Year: 2004
    ..it will be possible to induce sensations that appear to the amputee to emanate from specific regions of the fingers and hand...
  70. SYNTHESIS ANTI-HIV AGENTS THAT TARGET ZINC FINGERS
    MARK WELKER; Fiscal Year: 2000
    ..of new sulfur heterocycles which will chemically modify the nucleophilic cysteine residues in the NCp7 zinc fingers. All new heterocycles produced will be screened in collaboration with Dr...
  71. NMR STUDIES OF RETROVIRAL NUCLEIC ACID BINDING PROTEINS
    Michael Summers; Fiscal Year: 1993
    ..Although zinc fingers from DNA-binding proteins have received much recent attention, important questions exist regarding the structural ..
  72. Development and Evaluation of a VRX CT Scanner
    Frank DiBianca; Fiscal Year: 2006
    ..necks, breasts, extremities, larger research animals) 7-14 cylmm, and small sections (neonatal extremities, fingers, research mice) 24-42 cy/mm...
  73. MOLECULAR MECHANISMS IN EVI1-INDUCED MYELOID LEUKEMIA
    Archibald Perkins; Fiscal Year: 2000
    ..known to bind with high specificity to two sequences (GACAAGATA and GAAGATGAG) via two separate domains of zinc fingers, although the target genes on which it acts have not been described...
  74. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2004
    ..Char syndrome is an inherited heart-hand disorder comprising patent ductus arteriosus (PDA), abnormal 5th fingers, and facial dysmorphism...