hand

Summary

Top Publications

  1. ncbi Numbers within our hands: modulation of corticospinal excitability of hand muscles during numerical judgment
    Marc Sato
    Universita degli Studi di Parma, Italy
    J Cogn Neurosci 19:684-93. 2007
  2. pmc The influence of sex, handedness, and washing on the diversity of hand surface bacteria
    Noah Fierer
    Department of Ecology and Evolutionary Biology, University of Colorado, UCB 334, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 105:17994-9. 2008
  3. ncbi That's my hand! Activity in premotor cortex reflects feeling of ownership of a limb
    H Henrik Ehrsson
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Science 305:875-7. 2004
  4. ncbi Measuring the whole or the parts? Validity, reliability, and responsiveness of the Disabilities of the Arm, Shoulder and Hand outcome measure in different regions of the upper extremity
    D E Beaton
    Institute for Work and Health Toronto, Ontario, Canada
    J Hand Ther 14:128-46. 2001
  5. ncbi The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability
    Ann Christin Eliasson
    Neuropaediatric Research Unit, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Dev Med Child Neurol 48:549-54. 2006
  6. ncbi Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct
    R J Nudo
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, 77030, USA
    Science 272:1791-4. 1996
  7. pmc Modulation of training by single-session transcranial direct current stimulation to the intact motor cortex enhances motor skill acquisition of the paretic hand
    Maximo Zimerman
    Brain Imaging and Neurostimulation Labor, Department of Neurology, University Medical Center, Hamburg Eppendorf, Hamburg, Germany
    Stroke 43:2185-91. 2012
  8. ncbi Role of intracortical inhibition in selective hand muscle activation
    Cathy M Stinear
    Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand 1005, USA
    J Neurophysiol 89:2014-20. 2003
  9. ncbi Symptomatic hand osteoarthritis in the United States: prevalence and functional impairment estimates from the third U.S. National Health and Nutrition Examination Survey, 1991-1994
    Charles F Dillon
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA
    Am J Phys Med Rehabil 86:12-21. 2007
  10. doi Interhemispheric competition after stroke: brain stimulation to enhance recovery of function of the affected hand
    Dennis A Nowak
    Department of Neurology, University Hospital, University of Cologne, Cologne, Germany
    Neurorehabil Neural Repair 23:641-56. 2009

Research Grants

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
  3. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
  4. ANTHONY JOHN KANAI; Fiscal Year: 2016
  5. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
  6. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
  7. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
  8. Tobacco Control Research Branch Scientific and Technical Services Support
    KOURTNEY MARSHALL; Fiscal Year: 2009
  9. Junichi Sadoshima; Fiscal Year: 2016
  10. James B Martins; Fiscal Year: 2014

Detail Information

Publications448 found, 100 shown here

  1. ncbi Numbers within our hands: modulation of corticospinal excitability of hand muscles during numerical judgment
    Marc Sato
    Universita degli Studi di Parma, Italy
    J Cogn Neurosci 19:684-93. 2007
    ..Here, we used transcranial magnetic stimulation to study changes of excitability of hand muscles of individuals performing a visual parity judgment task, a task not requiring counting, on Arabic numerals ..
  2. pmc The influence of sex, handedness, and washing on the diversity of hand surface bacteria
    Noah Fierer
    Department of Ecology and Evolutionary Biology, University of Colorado, UCB 334, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 105:17994-9. 2008
    ..We used a novel pyrosequencing-based method that allowed us to survey hand surface bacterial communities at an unprecedented level of detail...
  3. ncbi That's my hand! Activity in premotor cortex reflects feeling of ownership of a limb
    H Henrik Ehrsson
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Science 305:875-7. 2004
    ..A perceptual illusion was used to manipulate feelings of ownership of a rubber hand presented in front of healthy subjects while brain activity was measured by functional magnetic resonance imaging...
  4. ncbi Measuring the whole or the parts? Validity, reliability, and responsiveness of the Disabilities of the Arm, Shoulder and Hand outcome measure in different regions of the upper extremity
    D E Beaton
    Institute for Work and Health Toronto, Ontario, Canada
    J Hand Ther 14:128-46. 2001
    The Disabilities of the Arm, Shoulder and Hand (DASH) outcome measure was developed to evaluate disability and symptoms in single or multiple disorders of the upper limb at one point or at many points in time.
  5. ncbi The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability
    Ann Christin Eliasson
    Neuropaediatric Research Unit, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Dev Med Child Neurol 48:549-54. 2006
    ..The intraclass correlation coefficient between therapists was 0.97 (95% confidence interval 0.96-0.98), and between parents and therapist was 0.96 (0.89-0.98), indicating excellent agreement...
  6. ncbi Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct
    R J Nudo
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, 77030, USA
    Science 272:1791-4. 1996
    ..A subtotal lesion confined to a small portion of the representation of one hand was previously shown to result in a further loss of hand territory in the adjacent, undamaged cortex of adult ..
  7. pmc Modulation of training by single-session transcranial direct current stimulation to the intact motor cortex enhances motor skill acquisition of the paretic hand
    Maximo Zimerman
    Brain Imaging and Neurostimulation Labor, Department of Neurology, University Medical Center, Hamburg Eppendorf, Hamburg, Germany
    Stroke 43:2185-91. 2012
    ..the capacity of cathodal transcranial direct current stimulation (tDCS) applied over the contralesional motor cortex during training to enhance the acquisition and retention of complex sequential finger movements of the paretic hand.
  8. ncbi Role of intracortical inhibition in selective hand muscle activation
    Cathy M Stinear
    Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand 1005, USA
    J Neurophysiol 89:2014-20. 2003
    ..Fifteen subjects were asked to rest their dominant hand on a computer mouse and depress the mouse button using their index finger in time with a 1-Hz auditory metronome, ..
  9. ncbi Symptomatic hand osteoarthritis in the United States: prevalence and functional impairment estimates from the third U.S. National Health and Nutrition Examination Survey, 1991-1994
    Charles F Dillon
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA
    Am J Phys Med Rehabil 86:12-21. 2007
    To estimate the United States prevalence of symptomatic hand osteoarthritis using American College of Rheumatology (ACR) physical examination criteria.
  10. doi Interhemispheric competition after stroke: brain stimulation to enhance recovery of function of the affected hand
    Dennis A Nowak
    Department of Neurology, University Hospital, University of Cologne, Cologne, Germany
    Neurorehabil Neural Repair 23:641-56. 2009
    ..motor areas in the contralesional and ipsilesional hemisphere has been applied in an attempt to enhance recovery of hand function following stroke...
  11. doi Hand movement direction decoded from MEG and EEG
    Stephan Waldert
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 28:1000-8. 2008
    ..To this end, we recorded whole-head MEG during center-out movements with the hand and found significant power modulation of MEG activity between rest and movement in three frequency bands: an ..
  12. pmc Learning to control a brain-machine interface for reaching and grasping by primates
    Jose M Carmena
    Department of Neurobiology, Duke University, Durham, North Carolina, USA
    PLoS Biol 1:E42. 2003
    ..e., hand position, velocity, gripping force, and the EMGs of multiple arm muscles) from the electrical activity of ..
  13. doi Closely overlapping responses to tools and hands in left lateral occipitotemporal cortex
    Stefania Bracci
    Center for Mind Brain Sciences CIMeC, University of Trento, Rovereto, Italy
    J Neurophysiol 107:1443-56. 2012
    ..Finally, functional connectivity analysis showed that the left LOTC hand/tool region was selectively connected, relative to neighboring body-, motion-, and object-responsive regions, with ..
  14. ncbi Optimal spatial filtering of single trial EEG during imagined hand movement
    H Ramoser
    Department of Medical Informatics, Institute of Biomedical Engineering, Graz University of Technology, Austria
    IEEE Trans Rehabil Eng 8:441-6. 2000
    ..g., associated with imaginary movement. One-sided hand movement imagination results in EEG changes located at contra- and ipsilateral central areas...
  15. ncbi Neural signatures of body ownership: a sensory network for bodily self-consciousness
    Manos Tsakiris
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Cereb Cortex 17:2235-44. 2007
    ..In the rubber hand illusion (RHI), correlated visuotactile stimulation causes a fake hand to be perceived as part of one's own body...
  16. ncbi Prefrontal involvement in imitation learning of hand actions: effects of practice and expertise
    Stefan Vogt
    Department of Psychology, Lancaster University, UK
    Neuroimage 37:1371-83. 2007
    In this event-related fMRI study, we demonstrate the effects of a single session of practising configural hand actions (guitar chords) on cortical activations during observation, motor preparation and imitative execution...
  17. ncbi Ipsilateral motor cortex activity during unimanual hand movements relates to task complexity
    Timothy Verstynen
    Deptartment of Psychology, University of California, Berkeley, CA 94720, USA
    J Neurophysiol 93:1209-22. 2005
    ..This phenomenon is more prominent in the left hemisphere during left-hand movements than in the right hemisphere during right-hand movements...
  18. ncbi Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The Framingham Study
    Yuqing Zhang
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Epidemiol 156:1021-7. 2002
    ..joint disorders in the elderly, yet few studies have targeted symptomatic osteoarthritis, especially symptomatic hand osteoarthritis...
  19. ncbi Neural circuits underlying imitation learning of hand actions: an event-related fMRI study
    Giovanni Buccino
    Dipartimento di Neuroscienze, Universita di Parma, Parma 43100, Italy
    Neuron 42:323-34. 2004
    ..Given the functional properties of area 46, a model of imitation learning is proposed based on interactions between this area and the mirror neuron system...
  20. ncbi Contribution of hand motor circuits to counting
    Michael Andres
    Universite Catholique de Louvain, Belgium
    J Cogn Neurosci 19:563-76. 2007
    The finding that number processing activates a cortical network partly overlapping that recruited for hand movements has renewed interest in the relationship between number and finger representations...
  21. ncbi Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Prof
    John M Boyce
    Hospital of Saint Raphael, New Haven, Connecticut, USA
    MMWR Recomm Rep 51:1-45, quiz CE1-4. 2002
    The Guideline for Hand Hygiene in Health-Care Settings provides health-care workers (HCWs) with a review of data regarding handwashing and hand antisepsis in health-care settings...
  22. ncbi Effects of correct and transformed visual feedback on rhythmic visuo-motor tracking: tracking performance and visual search behavior
    M Roerdink
    Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, 1081BT Amsterdam, The Netherlands
    Hum Mov Sci 24:379-402. 2005
    ..reduced to 9 in the analyses) manually tracked an oscillating visual target signal in phase (by moving the hand in the same direction as the target signal) and in antiphase (by moving the hand in the opposite direction), while ..
  23. ncbi Eye-hand coordination in object manipulation
    R S Johansson
    Department of Integrative Medical Biology, Section for Physiology, Umea University, S 90187 Umea, Sweden
    J Neurosci 21:6917-32. 2001
    ..Subjects never fixated the hand or the moving bar. Gaze and hand/bar movements were linked concerning landmarks, with gaze leading...
  24. ncbi The role of multiple contralesional motor areas for complex hand movements after internal capsular lesion
    Martin Lotze
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, D 72076 Tuebingen, Germany
    J Neurosci 26:6096-102. 2006
    ..In the subacute stage, increased activity within motor areas in the CON-H during simple movements of the affected hand has been shown to correlate with poorer motor outcome...
  25. doi Repetitive transcranial magnetic stimulation over bilateral hemispheres enhances motor function and training effect of paretic hand in patients after stroke
    Naoyuki Takeuchi
    Department of Rehabilitation Medicine, Hospital of Hokkaido University, Sapporo, Japan
    J Rehabil Med 41:1049-54. 2009
    ..We investigated whether bilateral repetitive transcranial magnetic stimulation might improve the paretic hand in patients after stroke.
  26. ncbi Establishing a standardized clinical assessment tool of pathologic and prosthetic hand function: normative data, reliability, and validity
    Colin M Light
    Department of Electronics and Computer Science, University of Southampton, Southampton, England
    Arch Phys Med Rehabil 83:776-83. 2002
    To develop a new assessment procedure, the Southampton Hand Assessment Procedure (SHAP), that allows contextual results of hand function to be obtained readily in a clinical environment.
  27. pmc Dorsal premotor neurons encode the relative position of the hand, eye, and goal during reach planning
    Bijan Pesaran
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 51:125-34. 2006
    ..the medial intraparietal area (area MIP) of two monkeys while systematically varying the starting position of the hand and eye during reaching. PMd neurons encoded the relative position of the target, hand, and eye...
  28. pmc Mechanisms underlying functional changes in the primary motor cortex ipsilateral to an active hand
    Monica A Perez
    Human Cortical Physiology Section and Stroke Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:5631-40. 2008
    Performance of a unimanual hand motor task results in functional changes in both primary motor cortices (M1(ipsilateral) and M1(contralateral))...
  29. ncbi Muscular and postural synergies of the human hand
    Erica J Weiss
    Department of Neuroscience, University of Minnesota, Minneapolis MN 55455, USA
    J Neurophysiol 92:523-35. 2004
    Because humans have limited ability to independently control the many joints of the hand, a wide variety of hand shapes can be characterized as a weighted combination of just two or three main patterns of covariation in joint rotations, ..
  30. pmc Integration of visual and tactile signals from the hand in the human brain: an FMRI study
    Giovanni Gentile
    Brain, Body and Self Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurophysiol 105:910-22. 2011
    ..In humans, activity in a similar set of brain regions has been associated with visuotactile stimulation of the hand. However, little is known about how these areas integrate visual and tactile information...
  31. ncbi Having a body versus moving your body: How agency structures body-ownership
    Manos Tsakiris
    Department of Psychology, Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Conscious Cogn 15:423-32. 2006
    We investigated how motor agency in the voluntary control of body movement influences body awareness. In the Rubber Hand Illusion (RHI), synchronous tactile stimulation of a rubber hand and the participant's hand leads to a feeling of the ..
  32. doi Dynamic intra- and interhemispheric interactions during unilateral and bilateral hand movements assessed with fMRI and DCM
    Christian Grefkes
    Neuromodulation and Neurorehabilitation Group, Max Planck Institute for Neurological Research, Cologne, Germany
    Neuroimage 41:1382-94. 2008
    ..the specific excitatory and inhibitory influences within the human motor system for the generation of voluntary hand movements...
  33. ncbi Activation of cortical and cerebellar motor areas during executed and imagined hand movements: an fMRI study
    M Lotze
    Institute for Medical Psychology, Tubingen, Germany
    J Cogn Neurosci 11:491-501. 1999
    Brain activation during executed (EM) and imagined movements (IM) of the right and left hand was studied in 10 healthy right-handed subjects using functional magnetic resonance imagining (fMRI)...
  34. ncbi Motor imagery: a backdoor to the motor system after stroke?
    Nikhil Sharma
    Department of Clinical Neurosciences, University of Cambridge, England
    Stroke 37:1941-52. 2006
    ..Specifically, whether the primary motor cortex (M1), considered a prime target of poststroke rehabilitation, is involved in motor imagery is unresolved...
  35. ncbi ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion--Part II: shoulder, elbow, wrist and hand
    Ge Wu
    Department of Physical Therapy, University of Vermont, 305 Rathwell Building, Burlington, VT, USA
    J Biomech 38:981-992. 2005
    ..of Biomechanics proposes a definition of a joint coordinate system (JCS) for the shoulder, elbow, wrist, and hand. For each joint, a standard for the local axis system in each articulating segment or bone is generated...
  36. pmc Upper limb amputees can be induced to experience a rubber hand as their own
    H Henrik Ehrsson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain 131:3443-52. 2008
    We describe how upper limb amputees can be made to experience a rubber hand as part of their own body...
  37. ncbi Mental rotation of objects versus hands: neural mechanisms revealed by positron emission tomography
    S M Kosslyn
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychophysiology 35:151-61. 1998
    ..The results suggest that at least two different mechanisms can be used in mental rotation, one mechanism that recruits processes that prepare motor movements and another mechanism that does not...
  38. ncbi A fronto-parietal circuit for object manipulation in man: evidence from an fMRI-study
    F Binkofski
    Department of Neurology, Heinrich Heine University of Dusseldorf, Germany
    Eur J Neurosci 11:3276-86. 1999
    ..It is proposed that area SII analyses the intrinsic object characteristics whilst the superior parietal lobule is related to kinaesthesia...
  39. ncbi Roles of primate spinal interneurons in preparation and execution of voluntary hand movement
    E E Fetz
    Department of Physiology and Biophysics and Washington National Primate Research Center, University of Washington, Seattle, WA 98195 7290 USA
    Brain Res Brain Res Rev 40:53-65. 2002
    To study the contribution of primate cervical interneurons (INs) to preparation and execution of normal voluntary hand movement we investigated their activity and correlational linkages to muscles in monkeys performing tracking tasks...
  40. pmc Functional results of the first human double-hand transplantation
    Jean Michel Dubernard
    Service de Chirurgie de Transplantation, Hopital Edouard Herriot, Place d Arsonval, 69347 Lyon, France
    Ann Surg 238:128-36. 2003
    Objective of this study was to analyze fifteen months after surgery the sensorimotor recovery of the first human double hand transplantation.
  41. ncbi Disinhibition of the premotor cortex contributes to a maladaptive change in the affected hand after stroke
    Naoyuki Takeuchi
    Department of Rehabilitation Medicine, Hospital of Hokkaido University, Sapporo, Japan
    Stroke 38:1551-6. 2007
    ..Using these data, we investigated whether a change in the inhibitory system might influence motor recovery...
  42. pmc Coherent neural representation of hand speed in humans revealed by MEG imaging
    Karim Jerbi
    Cognitive Neuroscience and Brain Imaging Laboratory, Centre National de la Recherche Scientifique, UPR 640 LENA, MEG Center, Universite Pierre et Marie Curie Paris 6, Hopital de la Salpetriere, 75013 Paris, France
    Proc Natl Acad Sci U S A 104:7676-81. 2007
    ..Recent findings obtained using local field potentials suggest that hand speed may also be encoded in the summed activity of neuronal populations...
  43. doi Influence of initial hand and target position on reach errors in optic ataxic and normal subjects
    Aarlenne Z Khan
    Espace et Action, INSERM U534, Bron, France
    J Vis 7:8.1-16. 2007
    ..studies suggest that reach planning areas in the posterior parietal cortex encode both target and initial hand position in gaze-centered coordinates, which could be used to calculate a desired movement vector...
  44. doi Time course analyses confirm independence of imitative and spatial compatibility
    Caroline Catmur
    ESRC Centre for Economic Learning and Social Evolution, University College London, 26 Bedford Way, London WC1H 0AP, United Kingdom
    J Exp Psychol Hum Percept Perform 37:409-21. 2011
    ..It was found that imitative compatibility follows a different time course from spatial compatibility, providing further evidence for their independence and supporting the use of imitative compatibility as a measure of imitation...
  45. pmc The SmartHand transradial prosthesis
    Christian Cipriani
    The BioRobotics Institute, Scuola Superiore Sant Anna, Pontedera Pi, Italy
    J Neuroeng Rehabil 8:29. 2011
    ..This paper presents the design and on bench evaluation of the SmartHand...
  46. pmc Impaired endogenously evoked automated reaching in Parkinson's disease
    Elizabeth B Torres
    Psychology Department, Rutgers University, Piscataway, New Jersey 08854, USA
    J Neurosci 31:17848-63. 2011
    ....
  47. pmc Software-recorded and self-reported duration of computer use in relation to the onset of severe arm-wrist-hand pain and neck-shoulder pain
    Stefan IJmker
    Research Centre on Physical Activity, Work and Health, TNO VU VUmc, Amsterdam, The Netherlands
    Occup Environ Med 68:502-9. 2011
    ..The objective of this study was to examine the association between duration of computer use at work, measured with software and self-reports, and the onset of severe arm-wrist-hand and neck-shoulder symptoms.
  48. pmc Eye-hand coordination skills in children with and without amblyopia
    Catherine M Suttle
    School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
    Invest Ophthalmol Vis Sci 52:1851-64. 2011
    ..whether binocular information provides benefits for programming and guidance of reach-to-grasp movements in normal children and whether these eye-hand coordination skills are impaired in children with amblyopia and abnormal binocularity.
  49. pmc Flexible, task-dependent use of sensory feedback to control hand movements
    David C Knill
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14618, USA
    J Neurosci 31:1219-37. 2011
    ..simple pointing movements leads humans to adjust the feedback control laws that map sensory signals from the moving hand to motor commands...
  50. doi Motor corticospinal excitability during the observation of interactive hand gestures
    Peter G Enticott
    Monash Alfred Psychiatry Research Centre, School of Psychology and Psychiatry, Monash University and the Alfred, Level 1, Old Baker Building, The Alfred, Melbourne, Victoria, 3004, Australia
    Brain Res Bull 85:89-95. 2011
    ..were administered transcranial magnetic stimulation (TMS) to the primary motor cortex while viewing matched hand movements with or without (1) an interactive context and (2) an interactive context with an implied heightened ..
  51. doi A case of refractory orofacial pain treated by transcranial direct current stimulation applied over hand motor area in combination with NMDA agonist drug intake
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Gottingen, Germany
    Brain Stimul 4:117-21. 2011
    ..A female patient presented with persistent orofacial pain on the right side for 3 years, attributed to a viral infection. The pain had remained largely pharmacoresistant, reaching a value of 8/10 on the visual analogue scale...
  52. doi FMRI adaptation reveals a cortical mechanism for the coding of space near the hand
    Claudio Brozzoli
    Brain, Body and Self Laboratory, Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Neurosci 31:9023-31. 2011
    ..ventral portions of the premotor cortex that exhibit selective BOLD adaptation to an object moving near the right hand. Crucially, these areas did not manifest adaptation if the stimulus was presented in far space (100 cm) or when the ..
  53. pmc Hand shape selection in pantomimed grasping: interaction between the dorsal and the ventral visual streams and convergence on the ventral premotor area
    Michiru Makuuchi
    Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany
    Hum Brain Mapp 33:1821-33. 2012
    In visually guided grasping, possible hand shapes are computed from the geometrical features of the object, while prior knowledge about the object and the goal of the action influence both the computation and the selection of the hand ..
  54. ncbi The precision of proprioceptive position sense
    R J van Beers
    Department of Industrial Design Engineering, Delft University of Technology, The Netherlands
    Exp Brain Res 122:367-77. 1998
    The purpose of this study was to determine the precision of proprioceptive localization of the hand in humans...
  55. ncbi Evolution of cortical activation during recovery from corticospinal tract infarction
    R S Marshall
    Columbia Presbyterian Medical Center, Columbia University, New York, NY, USA
    Stroke 31:656-61. 2000
    ..Functional MRI (fMRI) provides a means of identifying focal brain activity related to movement of a paretic hand. Although prior studies have suggested that supplementary motor regions in the ipsilesional and contralesional ..
  56. ncbi A comparison of surface and intramuscular myoelectric signal classification
    Levi J Hargrove
    Institute of Biomedical Engineering, Department of Electrical and Computer Engineering, University of New Brunswick, P O Box 4400, Fredericton, NB E3B 5A3, Canada
    IEEE Trans Biomed Eng 54:847-53. 2007
    ..Impressive classification accuracy (97%) could be achieved by optimally selecting only three channels of surface MES...
  57. pmc The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis
    Eric C Sayre
    Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada
    PLoS ONE 5:e10470. 2010
    Osteoarthritis (OA) has a significant impact on individuals' ability to work. Our goal was to investigate the effects of the site of OA (knee, hip, hand, foot, lower back or neck) on employment reduction due to OA (EROA).
  58. doi Influence of task-oriented training content on skilled arm-hand performance in stroke: a systematic review
    Annick A A Timmermans
    Eindhoven University of Technology, Eindhoven, Netherlands
    Neurorehabil Neural Repair 24:858-70. 2010
    This review evaluates the underlying training components currently used in task-oriented training and assesses the effects of these components on skilled arm-hand performance in patients after a stroke.
  59. doi The International Registry on Hand and Composite Tissue Transplantation
    Palmina Petruzzo
    Department of Transplantation, Hopital Edouard Herriot, Lyon, France
    Transplantation 90:1590-4. 2010
    The International Registry on Hand and Composite Tissue Transplantation was founded in May 2002, and the analysis of all cases with follow-up information up to July 2010 is presented here.
  60. pmc The Rubber Hand Illusion: feeling of ownership and proprioceptive drift do not go hand in hand
    Marieke Rohde
    Department of Cognitive Neuroscience, University of Bielefeld, Bielefeld, Germany
    PLoS ONE 6:e21659. 2011
    In the Rubber Hand Illusion, the feeling of ownership of a rubber hand displaced from a participant's real occluded hand is evoked by synchronously stroking both hands with paintbrushes...
  61. pmc Disturbances in body ownership in schizophrenia: evidence from the rubber hand illusion and case study of a spontaneous out-of-body experience
    Katharine N Thakkar
    Department of Psychology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e27089. 2011
    ..Body ownership, one component of self-awareness, can be studied with the rubber hand illusion (RHI)...
  62. pmc Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas
    H Henrik Ehrsson
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 25:10564-73. 2005
    In the "rubber-hand illusion," the sight of brushing of a rubber hand at the same time as brushing of the person's own hidden hand is sufficient to produce a feeling of ownership of the fake hand...
  63. ncbi Power Doppler ultrasound assessment of rheumatoid hand synovitis
    M Stone
    Department of Rheumatology, Mater Misericordiae Hospital, Dublin, Ireland
    J Rheumatol 28:1979-82. 2001
    ..power Doppler ultrasound (PD) as a technique in assessing response to treatment with steroids in rheumatoid hand synovitis...
  64. ncbi Visual feedback control of hand movements
    Jeffrey A Saunders
    Center for Visual Science, University of Rochester, Center for Visual Science, Rochester, New York 14627, USA
    J Neurosci 24:3223-34. 2004
    We investigated what visual information contributes to on-line control of hand movements. It has been suggested that motion information predominates early in movements but that position information predominates for endpoint control...
  65. ncbi Spatial transformations for eye-hand coordination
    J D Crawford
    Canadian Institutes of Health Research Group for Action and Perception, York Centre for Vision Research, Department of Psychology, York University, 4700 Keele St, Toronto, Ontario M3J 1P3, Canada
    J Neurophysiol 92:10-9. 2004
    Eye-hand coordination is complex because it involves the visual guidance of both the eyes and hands, while simultaneously using eye movements to optimize vision...
  66. ncbi Lateral somatotopic organization during imagined and prepared movements
    Pascale Michelon
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    J Neurophysiol 95:811-22. 2006
    ..specific to the body part whose movement is imagined or prepared, participants performed, imagined, and prepared hand movements while undergoing functional MRI scanning...
  67. ncbi Differential roles of monkey striatum in learning of sequential hand movement
    S Miyachi
    Laboratory of Neural Control, National Institute for Physiological Sciences, Okazaki, Japan
    Exp Brain Res 115:1-5. 1997
    ..These results suggest that the anterior and posterior portions of the striatum participate in different aspects of learning of sequential movements...
  68. ncbi Ipsilesional deficits during fast diadochokinetic hand movements following unilateral brain damage
    J Hermsdorfer
    Clinical Research Group EKN, Neuropsychological Department, Munchen Bogenhausen Hospital, Dachauerstr 164, Germany
    Neuropsychologia 40:2100-15. 2002
    Impaired sensorimotor function of the hand ipsilateral to a unilateral brain lesion has been reported in a variety of motor tasks; however, elementary diadochokinetic movements, such as tapping with the index finger, seem to be preserved ..
  69. ncbi The impact of physical therapy on functional outcomes after stroke: what's the evidence?
    R P S Van Peppen
    Department of Physical Therapy, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Rehabil 18:833-62. 2004
    ..To determine the evidence for physical therapy interventions aimed at improving functional outcome after stroke...
  70. ncbi Hand impairments and their relationship with manual ability in children with cerebral palsy
    Carlyne Arnould
    Laboratory of Rehabilitation and Physical Medicine, Universite Catholique de Louvain, Bruxelles, Belgium
    J Rehabil Med 39:708-14. 2007
    To study hand impairments and their relationship with manual ability in children with cerebral palsy.
  71. ncbi Functional properties of grasping-related neurons in the ventral premotor area F5 of the macaque monkey
    Vassilis Raos
    Dipartimento di Neuroscienze, Sezione di Fisiologia, Universita di Parma, Parma, Italy
    J Neurophysiol 95:709-29. 2006
    ..Because the same paradigm has been used to study the properties of hand-grasping neurons in the dorsal premotor area F2, and in the anterior intraparietal area (AIP), a comparison of the ..
  72. doi Mirror activity in the human brain while observing hand movements: a comparison between EEG desynchronization in the mu-range and previous fMRI results
    Anat Perry
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Brain Res 1282:126-32. 2009
    ..The EEG power in the mu range has been recorded while participants passively observed either a left or a right hand, reaching to and grasping objects, and compared it with that recorded while participants observed the movement of a ..
  73. doi Manual activity shapes structure and function in contralateral human motor hand area
    Oliver Granert
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neuroimage 54:32-41. 2011
    ..e., training) of manual activity lead to opposing changes in grey matter in the contralateral primary motor hand area (M1(HAND))...
  74. pmc The primate reticulospinal tract, hand function and functional recovery
    Stuart N Baker
    Institute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    J Physiol 589:5603-12. 2011
    ..Recent data provide evidence that the reticulospinal tract can exert some influence over hand movements...
  75. doi Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranical magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke
    Naoyuki Takeuchi
    Department of Rehabilitation Medicine, Hospital of Hokkaido University, Sapporo, Japan
    J Rehabil Med 40:298-303. 2008
    ..repetitive transcranial magnetic stimulation (rTMS) over the unaffected hemisphere improved the affected hand function in chronic stroke patients...
  76. ncbi Evidence for the flexible sensorimotor strategies predicted by optimal feedback control
    Dan Liu
    Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093 0515, USA
    J Neurosci 27:9354-68. 2007
    ..diverse and often conflicting mixtures of task goals, requiring sensorimotor strategies customized for the task at hand. Such customization is mostly ignored by traditional theories emphasizing movement geometry and servo control...
  77. doi The role of the right temporo-parietal junction in maintaining a coherent sense of one's body
    Manos Tsakiris
    Department of Psychology, Royal Holloway University of London, Egham, Surrey, United Kingdom
    Neuropsychologia 46:3014-8. 2008
    ....
  78. doi Referral of sensation to an advanced humanoid robotic hand prosthesis
    Birgitta Rosén
    Department of Hand Surgery, Malmo University Hospital, Malmo, Sweden
    Scand J Plast Reconstr Surg Hand Surg 43:260-6. 2009
    b>Hand prostheses that are currently available on the market are used by amputees to only a limited extent, partly because of lack of sensory feedback from the artificial hand...
  79. doi Hand bone loss measured by digital X-ray radiogrammetry is a predictor of joint damage in early rheumatoid arthritis
    K Forslind
    Department of Medicine, Section of Rheumatology, Helsingborg Hospital, Sweden
    Scand J Rheumatol 38:431-8. 2009
    ..The aim of this study was to evaluate whether loss of bone measured by digital X-ray radiogrammetry (DXR) of hands early in the course of rheumatoid arthritis (RA) may predict future radiographic joint damage after 1 and 2 years...
  80. ncbi Somatosensory evoked potentials during a rubber-hand illusion in schizophrenia
    Avi Peled
    Institute for Psychiatric Studies, Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Hadera, Israel
    Schizophr Res 64:157-63. 2003
    The rubber-hand illusion (RHI), an illusion in which tactile sensations are referred to a synthetic alien limb, is enhanced in schizophrenia patients...
  81. pmc Dual-hemisphere tDCS facilitates greater improvements for healthy subjects' non-dominant hand compared to uni-hemisphere stimulation
    Bradley W Vines
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    BMC Neurosci 9:103. 2008
    ..shown that applying anodal tDCS to the non-dominant motor cortex can improve motor performance for the non-dominant hand, presumably by means of changes in synaptic plasticity between neurons...
  82. ncbi Extending or projecting peripersonal space with tools? Multisensory interactions highlight only the distal and proximal ends of tools
    Nicholas P Holmes
    Department of Experimental Psychology, South Parks Road, Oxford, OX13UD, Oxford University, UK
    Neurosci Lett 372:62-7. 2004
    ..tasks on the integration of visual and tactile stimuli at three distances from participants' hands along two hand-held tools...
  83. ncbi Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation
    Paulo S Boggio
    Department of Experimental Psychology, University of Sao Paulo, Brazil
    Neurosci Lett 404:232-6. 2006
    ..investigate the effects of anodal tDCS (1 mA, 20 min) of the dominant and non-dominant primary motor cortex (M1) on hand motor performance in healthy right-handed volunteers, healthy subjects underwent one session of both sham and ..
  84. pmc Tool use changes multisensory interactions in seconds: evidence from the crossmodal congruency task
    Nicholas P Holmes
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Exp Brain Res 183:465-76. 2007
    ..Such enhancements are likely due to the increased behavioural relevance of visual stimuli as each tool use action is prepared before execution...
  85. ncbi Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery
    S B Frost
    Center on Aging, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurophysiol 89:3205-14. 2003
    ..stimulation techniques to examine functional remodeling in cerebral cortex after an ischemic infarct in the hand representation of primary motor cortex in five adult squirrel monkeys...
  86. ncbi Target and hand position information in the online control of goal-directed arm movements
    Fabrice Sarlegna
    UMR Mouvement and Perception, CNRS et Universite de la Mediterranee, 163 Avenue de Luminy, 13288, Marseille Cedex 9, France
    Exp Brain Res 151:524-35. 2003
    The present study compared the contribution of visual information of hand and target position to the online control of goal-directed arm movements...
  87. pmc Continuous attraction toward phonological competitors
    Michael J Spivey
    Department of Psychology, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 102:10393-8. 2005
    ..Here, we provide compelling evidence for this continuity assumption by using a continuous response, hand movements, to track the temporal dynamics of lexical activations during real-time spoken-word recognition in a ..
  88. pmc The shortened disabilities of the arm, shoulder and hand questionnaire (QuickDASH): validity and reliability based on responses within the full-length DASH
    Christina Gummesson
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    BMC Musculoskelet Disord 7:44. 2006
    The 30-item disabilities of the arm, shoulder and hand (DASH) questionnaire is increasingly used in clinical research involving upper extremity musculoskeletal disorders...
  89. ncbi Internalizing agency of self-action: perception of one's own hand movements depends on an adaptable prediction about the sensory action outcome
    Matthis Synofzik
    Department of Cognitive Neurology, Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, Germany
    J Neurophysiol 96:1592-601. 2006
    ..Furthermore, they indicate that the updated sensory prediction can be used to optimize motor control...
  90. ncbi A 'rubber-hand' illusion reveals a relationship between perceptual body image and unhealthy body change
    Alexander J Mussap
    School of Psychology, Deakin University, Australia
    J Health Psychol 11:627-39. 2006
    The 'rubber-hand' illusion, in which individuals misattribute tactile sensations felt by their hand to a rubber prosthetic hand that they see being stimulated, was employed to examine the relationship between perceptual body image and ..
  91. ncbi Prevalence and involvement patterns of radiographic hand osteoarthritis in Japanese women: the Hizen-Oshima Study
    Naoki Toba
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    J Bone Miner Metab 24:344-8. 2006
    The prevalence and pattern of joint involvement in radiographic hand osteoarthritis (OA) have been reported in Western populations, but similar data are lacking for Japanese...
  92. ncbi Evidence-based model for hand transmission during patient care and the role of improved practices
    Didier Pittet
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    Lancet Infect Dis 6:641-52. 2006
    b>Hand cleansing is the primary action to reduce health-care-associated infection and cross-transmission of antimicrobial-resistant pathogens...
  93. ncbi Control strategies in object manipulation tasks
    J Randall Flanagan
    Department of Psychology, Centre for Neuroscience Studies, Queen s University, Kingston, ON, K7L 3N6, Canada
    Curr Opin Neurobiol 16:650-9. 2006
    The remarkable manipulative skill of the human hand is not the result of rapid sensorimotor processes, nor of fast or powerful effector mechanisms...
  94. pmc Design of a cybernetic hand for perception and action
    M C Carrozza
    ARTS Lab, Scuola Superiore Sant Anna, Pontedera Pi, Italy
    Biol Cybern 95:629-44. 2006
    Strong motivation for developing new prosthetic hand devices is provided by the fact that low functionality and controllability-in addition to poor cosmetic appearance-are the most important reasons why amputees do not regularly use their ..
  95. ncbi Pegylated liposomal doxorubicin-related palmar-plantar erythrodysesthesia ('hand-foot' syndrome)
    D Lorusso
    Department of Oncology, Catholic University of the Sacred Heart, Campobasso, Italy
    Ann Oncol 18:1159-64. 2007
    Palmar-plantar erythrodysesthesia (PPE), also called hand-foot syndrome or hand-to-foot syndrome, is a distinctive and relatively frequent dermatologic toxic reaction associated with certain chemotherapeutic agents...
  96. ncbi Hand-held dynamometry for muscle strength measurement in children with cerebral palsy
    Jodi Crompton
    Rehabilitation Sciences Research Centre, School of Physiotherapy, The University of Melbourne, Parkville, Victoria, 3108 Australia
    Dev Med Child Neurol 49:106-11. 2007
    The aim of this study was to investigate the reliability of hand-held dynamometry for measuring isometric lower-limb muscle strength in children with cerebral palsy (CP)...
  97. ncbi On the relations between affordance and representation of the agent's effector
    Filippo Barbieri
    Dipartimento di Neuroscienze, Universita di Parma, Via Volturno 39, 43100 Parma, Italy
    Exp Brain Res 180:421-33. 2007
    ..of the effector potentially interacting with the object: specifically, in this study, vision of the interacting hand. In Experiment 1 we used an apparatus by which a fruit to be reached and grasped was identified by word reading, ..
  98. pmc The epidemiology of arm and hand swelling in premenopausal breast cancer survivors
    Electra D Paskett
    Ohio State University Comprehensive Cancer Center, A356 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA
    Cancer Epidemiol Biomarkers Prev 16:775-82. 2007
    Breast cancer survivors suffer from lymphedema of the arm and/or hand. Accurate estimates of the incidence and prevalence of lymphedema are lacking, as are the effects of this condition on overall quality of life.
  99. ncbi Field trial of a low cost method to evaluate hand cleanliness
    Stephen P Luby
    Division of Bacterial and Mycotic Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Trop Med Int Health 12:765-71. 2007
    To evaluate a simple low cost method for measuring hand contamination as an objective assessment of handwashing practices.
  100. pmc The Clinical Assessment Study of the Hand (CAS-HA): a prospective study of musculoskeletal hand problems in the general population
    Helen Myers
    Primary Care Musculoskeletal Research Centre, Keele University, Keele, Staffordshire, ST5 5BG, UK
    BMC Musculoskelet Disord 8:85. 2007
    Pain in the hand affects an estimated 12-21% of the population, and at older ages the hand is one of the most common sites of pain and osteoarthritis...
  101. ncbi Parallel evolution of cortical areas involved in skilled hand use
    Jeffrey Padberg
    Center for Neuroscience, University of California, Davis, California 95618, USA
    J Neurosci 27:10106-15. 2007
    ....

Research Grants80

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  3. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..and city schools, focusing on the interaction between physical fitness, obesity, and metabolic syndrome on the one hand, and allergic responses and inflammation on the other...
  4. ANTHONY JOHN KANAI; Fiscal Year: 2016
    ..On the other hand, intracolonic administration of the antagonists blocked cross-sensitization and cystitis due to colonic irradiation...
  5. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..With this information in hand, it should be possible to design drugs with fewer side-effects...
  6. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..Smoking and aging can result in higher amounts of citrullination. On the other hand, DQ8 can present native and de-amidated peptides thus generating a robust immune response to an antigen...
  7. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..Therefore, our work should help understand why signals fail, or get out of hand. This occurs in diseases, including muscular dystrophies, malignant hyperthermia, and others...
  8. Tobacco Control Research Branch Scientific and Technical Services Support
    KOURTNEY MARSHALL; Fiscal Year: 2009
    ..Diseases or conditions which may be directly or indirectly caused by smoking or tobacco use, including second-hand smoke or involuntary smoking...
  9. Junichi Sadoshima; Fiscal Year: 2016
    ..On the other hand, phosphorylation/inactivation of GSK-3b during reperfusion is beneficial through activation of mTOR. 3...
  10. James B Martins; Fiscal Year: 2014
    ..All the techniques required for these studies are in hand in the laboratories where this preliminary work was done...
  11. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..Our pump is currently made by hand, a long and tedious process...
  12. JAMES M COGHILL; Fiscal Year: 2015
    ..Dr. Coghill will learn first-hand from an expert mentoring team led by Drs...
  13. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..On the other hand, plasma free heme has been incriminated in the genesis of CM...
  14. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..CMT patients suffer from degeneration of the peripheral nerves that control sensory information of the foot/leg and hand/arm. The nerve degeneration causes the subsequent degeneration of the muscles in the extremities...
  15. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..SHM, on the other hand, introduces point mutations into V genes at a very high rate, ultimately leading to increased antibody affinity...
  16. Danny A Riley; Fiscal Year: 2014
    ..manufacturing, agriculture-forestry and fishing, and mining Sectors and are currently exposed to levels of hand-arm vibration putting them at risk for developing hand-arm vibration syndrome (HAVS) with a prevalence of 10-50% ..
  17. BEATRICE JENNY KIRATLI; Fiscal Year: 2014
    ..in the following variables will be evaluated: balance, strength, active range of movement per joint, coordination, hand and shoulder function, and compared across groups, matching for injury level as described above...
  18. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..When we have mutations in individual genes in hand, we will examine their phenotypes in detail and analyze their epistatic relationships with each other, as well as ..
  19. A fully validated assay to identify activators of ERSR in human glioma cells: ide
    Maurizio Grimaldi; Fiscal Year: 2012
    ..On the other hand, normal glial cells and neurons seem to be resistant to ERSR-mediated cell death...
  20. Albert Anderson; Fiscal Year: 2016
    ..The prevalence of HIV-associated neurocognitive disorder (HAND) is increasing. The presence of HAND is a risk factor for work disability, poor quality of life, and mortality...
  21. Intermediary Metabolism, Histone Acetylation, and Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2013
    ..On the other hand, many HDAC inhibitors reactivate the transcription of multiple genes that are silenced in cancer and thus possess ..
  22. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    ..SEMA3F inhibits tumor angiogenesis and metastasis, whereas NRPs, on the other hand, promote VEGF-dependent angiogenesis...
  23. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..On the other hand, as defined in the NIH roadmap molecular imaging plays an increasingly important role in the advancement of ..
  24. Exploring persistent epigenetic changes after prenatal famine exposure in humans
    L H Lumey; Fiscal Year: 2010
    ..between maternal famine exposure in the periconceptional period and in different stages of pregnancy on the one hand and DNA methylation patterns in adulthood on the other...
  25. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
    ..Toxicity of SB-505124 in GFS was shown to be substantially lower than that of MMC. On the other hand, while the bleb survival was improved by SB-505124, the survival period of GFS with SB-505124 was still shorter ..
  26. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..On the other hand, PI3 kinase activates protein kinase B (PKB = Akt)...
  27. Robot-Assisted MRI-Guided Prostate Biopsy
    Dan Stoianovici; Fiscal Year: 2010
    ..On the other hand some PCs are aggressive, killing 28,000 US men annually...
  28. Irritable bowel syndrome-diarrhea: the role of gluten intolerance and HLA-DQ2
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..Community studies suggest that celiac disease affects 0.5 to 1.0% of people in the USA. On the other hand, there is increasing recognition of a potential role of intolerance to gluten in patients with IBS-D or FD...
  29. CHRISTOPHER KIRK THOMPSON; Fiscal Year: 2014
    ..He wil also have the publication record and preliminary data on hand to write a R01 proposal with a high likelihood of funding...
  30. Veena Taneja; Fiscal Year: 2014
    ..On the other hand, DQ8 can present native and de-amidated peptides derived from synovial proteins generating a robust autoimmune ..
  31. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..status, and quality of life (Specific Aim #3: life space mobility, Short Physical Performance Battery, leg and hand grip strength, Short Form-36 Health Related Quality of Life, Impact of Weight on Quality of Life-Lite)...
  32. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    ..On the other hand, an orderly supply of osteoblasts and osteoclasts are needed for maintaining the critical bone homeostasis...
  33. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ..On the other hand, we have shown in PAC and PDAC cells in vitro that the stimulating cAMP signaling downstream of b-ARs is inhibited ..
  34. Ezra Burstein; Fiscal Year: 2016
    ..On the other hand, clinical and translational research involves formal training in study design, including ethics and biostatics, ..
  35. MICHAEL A O'REILLY; Fiscal Year: 2016
    ..to elevated oxygen at birth are more likely to have viral infections, asthma, increased sensitivity to second hand cigarette smoke, and more out-of-school sick days than children who were not exposed to oxygen...
  36. Elizabeth R Jacobs; Fiscal Year: 2016
    ..We are uniquely positioned to test novel therapeutic interventions to improve IR lung injury with prognostic and mechanistic information in hand.
  37. Sulie L Chang; Fiscal Year: 2014
    ..been correlated with neurodegenerative diseases and behavioral disorders, such as HIV-1 induced neurodegeneration (HAND) and HIV-1 induced dementia (HAD)...
  38. Endocrine Targets for Prevention of Lung Cancer
    Robert M Bigsby; Fiscal Year: 2012
    ..On the other hand, using the antiprogestin, mifepristone, we will determine the role of PR in tumor progression...
  39. Stavros C Manolagas; Fiscal Year: 2015
    ..On the other hand ROS are required for osteoclast generation, function, and survival...
  40. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2012
    ..hypotheses we have evolved over the past decade using exciting new genetically modified mice that are now in hand. These mice, and their tissues and cells, enable the precise deletion of ER1 or ER2 from either EC or VSMC and ..
  41. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    ..On the other hand, acupuncture has been used extensively for treatment of various painful conditions and gastrointestinal diseases in ..
  42. Ciaran P Kelly; Fiscal Year: 2015
    ..is currently commercially available, and measures to prevent CDAD through patient isolation and implementation of hand-hygiene and contact precautions have had variable and often limited success. We propose to develop a recombinant C...
  43. Adam Lin; Fiscal Year: 2014
    ..They also have known toxicities post degradation. Gold nanoparticles (AuNPs), on the other hand, have three advantages: potential lymph drainage due to their small size, simplistic synthesis/conjugation process ..
  44. Microfluidic-microtiter interface for rapid large-scale screenings of C. elegans
    Adela Ben Yakar; Fiscal Year: 2010
    ..On the other hand, thanks to their simplicity and large similarities to mammals, the use of small invertebrate animals is of great ..
  45. Abidemi Bolu Ajiboye; Fiscal Year: 2015
    ..SCI a natural and volitionally controlled FES command interface for regaining functional control of the arm and hand. The role of the brain in controlling arm and hand movements has been extensively studied in able-bodied non-human ..
  46. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..We propose to do this via a two-pronged approach involving protein purification and mass spectrometry on the one hand, and screening of systematic collections of yeast ER membrane proteins on the other...
  47. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..microti infect the salivary glands of the tick, hence poised to exit the tick vector during feeding. On the other hand, B...
  48. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    ..S. According to the CDC, most cases of human enteroviral encephalitis resolve without complication. One the other hand, herpes simplex encephalitis results in rapid death in approximately 70% of cases if left untreated...
  49. Wei Xing Zong; Fiscal Year: 2016
    ..On the other hand, we also found that SCCA1 promotes apoptosis in response to proteotoxic stress...
  50. Kamel Khalili; Fiscal Year: 2015
    ..cognitive disorders and peripheral neuropathies remain significant in HIV-1 associated neurological disorders (HAND) even in the HAART era...
  51. Role of Id1 in NSCLC Progression and Metastasis
    Srikumar P Chellappan; Fiscal Year: 2013
    ..At the same time, only about 10-20% of smokers are afflicted with NSCLC. On the other hand, 25% of NSCLC patients are non-smokers...
  52. Estrogen receptor, p38 MAPKs and topo IIa in breast cancer
    Guan Chen; Fiscal Year: 2013
    ..DNA topoisomerase II1 (topo II1), on the other hand, maintains proper DNA topology and acts as a therapeutic target for both ER+ and ER- breast cancer...
  53. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    JAMES PRESTON MAPES; Fiscal Year: 2011
    ..Delaying treatment until symptoms arise can be life threatening. On the other hand, recurrent treatment with antibiotics in non- infants holds potential risks to these infants by furthering the ..
  54. Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
    SHANNON MARIE BAILEY; Fiscal Year: 2013
    ..aspects: 1) widespread hyperlipidemia and 2) pervasive exposure to airborne environmental toxicants like second-hand cigarette smoke, a.k.a. environmental tobacco smoke (ETS)...
  55. Skeletal Muscle Mitochondrial Adaptations to a Two-Year Caloric Restiction
    STEVEN RICHARD SMITH; Fiscal Year: 2012
    ..Importantly, we will measure mitochondrial ROS production and ROS damage to fully test the hypotheses at hand;namely that CR will increase coupling, reduce ROS production and decrease ROS damage...
  56. Michael Freitag; Fiscal Year: 2015
    ..preliminary data have been accumulated, most materials and methods to address underlying mechanisms are at hand, and currently no other lab is working on this fundamental problem with filamentous fungi...
  57. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..On the other hand, other viruses such as influenza and varicella predispose to exaggerated immune responses that prime the host for ..
  58. Combination Clostridium Difficile Toxin and Adhesin Vaccine
    Ciaran P Kelly; Fiscal Year: 2011
    ..is currently commercially available, and measures to prevent CDAD through patient isolation and implementation of hand-hygiene and contact precautions have had variable and often limited success. We propose to develop a recombinant C...
  59. Hong Li; Fiscal Year: 2015
    ..On the other hand, successfully disseminated mobile elements can benefit the bacterial hosts, for instance, by introducing ..
  60. Harry L Mobley; Fiscal Year: 2016
    ..On the other hand, in patients with complicated urinary tracts, ones in which normal urine flow are blocked by structural abnormality ..
  61. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..If the proposed aims are achieved, we not only would have in hand an optimized vaccine formulation to be assayed in ruminants but we will also put forward a new concept of how to ..
  62. Joseph Y Cheung; Fiscal Year: 2014
    ..We already have 2 genetically engineered mice (PLM-KO, inducible PLMS68E TG) on hand, and we are confident that given the resources, we will be able to generate inducible PLMS68E TG in PLM-KO ..
  63. OSTEOARTHRITIS & OSTEOPOROSIS IN ELDERLY WOMAN
    Michael Nevitt; Fiscal Year: 1992
    ..Therefore, we will study bone mass in the hip in relation to hip OA, bone mass in the radius in relation to hand OA, and bone mass in the spine in relation to spine OA...
  64. Exchangeable Heart Valve for Tissue Engineering Applications
    Ivan Vesely; Fiscal Year: 2007
    ..Mechanical valves, on the other hand, because anticoagulation-related complications and used only if the patient is too young to receive a bioprosthesis...
  65. Phase-contrast enhanced X-ray imaging system for small joints of hand
    Thomas J Beck; Fiscal Year: 2010
    ..It initially attacks the small joints of the hand and foot...
  66. Primate Model of Stroke and Recovery in Aging
    Tara Moore; Fiscal Year: 2009
    ..performance, a unilateral lesion will be made in the area of the motor cortex identified as controlling the digits, hand and forearm. The lesion will produce impairment in the use of the contralateral hand...
  67. Artificial Hand: A New Device for Ingested Foreign Bodies Removal
    VLADIMIR RUBTSOV; Fiscal Year: 2007
    ..of a flexible, safe tool that can, ideally, mimic human fingers (there is nothing more articulating than the human hand) is the dream of physicians involved in these procedures...
  68. Effect of tool design on hand pain in dental practiioners
    David M Rempel; Fiscal Year: 2010
    ..by applicant): This is a randomized controlled trial to evaluate the effects of a new dental tool handle design on hand and arm symptoms and function among 120 dental hygienists and dentists who perform dental scaling...
  69. Glycogen synthase kinase-3beta: a setpoint for dopamine dysfunction in neuroAIDS
    Seth Perry; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): HIV-associated neurologic disease (HAND) remains a source of significant morbidity, and is increasing in prevalence, despite success reducing viral load in HIV-infected individuals with highly active ..
  70. AMES+Brain Stimulation: Treatment for Profound Plegia in Stroke
    Paul Cordo; Fiscal Year: 2010
    ..by applicant): An estimated 30% of chronic stroke patients with motor disabilities of the limbs are plegic in the hand or the foot - that is, they cannot move the hand or foot...
  71. RRSS #1 - Evaluation of Process Efficiency in the Task of Case Consolidation with
    Kevin Ward; Fiscal Year: 2009
    ..The underlying key to these methodologies is to let the data drive continual improvement of the process at hand. Almost every process has some degree of waste associated with it...
  72. Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania
    Joseph Himle; Fiscal Year: 2007
    ..The device will monitor relative body position between the hand and the effected hair, creating awareness by signaling the user, using vibration and/or sound, prior to pulling...
  73. Joseph D Towles; Fiscal Year: 2014
    ..of the median or ulnar nerve in the veteran population is one of the most frequently encountered disorders seen by hand surgeons...
  74. Childhood Illness and Risk Perception: Opportunity to Improve Handwashing
    Pavani Kalluri Ram; Fiscal Year: 2010
    ..proven health benefits of handwashing, data from numerous settings confirm that individuals do not practice good hand hygiene at the appropriate times...
  75. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian-Smith; Fiscal Year: 2012
    ..by applicant): Cervical dorsal root injuries that result in the deafferentation of the fingers can severely impair hand function, especially the execution of manual tasks that depend on continuous sensory feedback (i.e...
  76. CASE CROSSOVER STUDY OF OCCUPATIONAL HAND INJURIES
    Murray Mittleman; Fiscal Year: 2000
    ..4 million emergency department visits for occupational upper extremity trauma, 80% of which involved the fingers, hand or wrist...
  77. One Dimensional Hand Held Gamma Ray Scanner
    FARHAD DAGHIGHIAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): 1-D Hand-held Gamma Ray Scanner Daghighian, PI Phase I SBIR Dec. 2008 During surgery anatomy and physiology are often altered...
  78. DIGITAL HAND ATLAS IN ASSESSMENT OF SKELETAL DEVELOPMENT
    H K Huang; Fiscal Year: 2006
    ..The most common clinical method for bone age assessment is atlas matching by a left-hand wrist radiograph against a small reference set of atlas patterns of normal standards developed by Greulich and Pyle ..
  79. Implanted Neuroprosthesis for Restoring Arm and Hand Function after Stroke
    Jayme Knutson; Fiscal Year: 2009
    ..One of the most frequently persisting consequences of stroke is impaired hand function...
  80. Holographic Sonic Flashlighlt for Guiding Interventional Procedures
    George Stetten; Fiscal Year: 2009
    ..The hand-held device permits insertion of needles directly into a virtual image of the ultrasound scan, which floats beneath ..