arm

Summary

Summary: The superior part of the upper extremity between the SHOULDER and the ELBOW.

Top Publications

  1. doi Functional magnetic resonance imaging reveals the neural substrates of arm transport and grip formation in reach-to-grasp actions in humans
    Cristiana Cavina-Pratesi
    Department of Psychology, Durham University, Durham DH13LE, United Kingdom
    J Neurosci 30:10306-23. 2010
  2. pmc Reach and grasp by people with tetraplegia using a neurally controlled robotic arm
    Leigh R Hochberg
    Rehabilitation Research and Development Service, Department of Veterans Affairs, Providence, Rhode Island 02908, USA
    Nature 485:372-5. 2012
  3. ncbi Control of fast-reaching movements by muscle synergy combinations
    Andrea d'Avella
    Department of Neuromotor Physiology, Santa Lucia Foundation, 00179 Rome, Italy
    J Neurosci 26:7791-810. 2006
  4. pmc Supplementary motor area exerts proactive and reactive control of arm movements
    Xiaomo Chen
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 30:14657-75. 2010
  5. pmc Effects of robot-assisted therapy on upper limb recovery after stroke: a systematic review
    Gert Kwakkel
    Department Rehabilitation Medicine and Research Institute MOVE, VU University Medical Center Amsterdam, The Netherlands
    Neurorehabil Neural Repair 22:111-21. 2008
  6. ncbi Prediction of arm movement trajectories from ECoG-recordings in humans
    Tobias Pistohl
    Bernstein Center for Computational Neuroscience, Albert Ludwigs University, Freiburg, Germany
    J Neurosci Methods 167:105-14. 2008
  7. ncbi Ambulatory measurement of arm orientation
    H J Luinge
    Xsens Technologies b v, Enschede, The Netherlands
    J Biomech 40:78-85. 2007
  8. pmc Learning to control a brain-machine interface for reaching and grasping by primates
    Jose M Carmena
    Department of Neurobiology, Duke University, Durham, North Carolina, USA
    PLoS Biol 1:E42. 2003
  9. doi Deep brain stimulation of subthalamic nuclei affects arm response inhibition in Parkinson's patients
    G Mirabella
    Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, 86077 Pozzilli IS, Italy
    Cereb Cortex 22:1124-32. 2012
  10. pmc Decoding complete reach and grasp actions from local primary motor cortex populations
    Carlos E Vargas-Irwin
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 30:9659-69. 2010

Detail Information

Publications386 found, 100 shown here

  1. doi Functional magnetic resonance imaging reveals the neural substrates of arm transport and grip formation in reach-to-grasp actions in humans
    Cristiana Cavina-Pratesi
    Department of Psychology, Durham University, Durham DH13LE, United Kingdom
    J Neurosci 30:10306-23. 2010
    Picking up a cup requires transporting the arm to the cup (transport component) and preshaping the hand appropriately to grasp the handle (grip component)...
  2. pmc Reach and grasp by people with tetraplegia using a neurally controlled robotic arm
    Leigh R Hochberg
    Rehabilitation Research and Development Service, Department of Veterans Affairs, Providence, Rhode Island 02908, USA
    Nature 485:372-5. 2012
    ..Able-bodied monkeys have used a neural interface system to control a robotic arm, but it is unknown whether people with profound upper extremity paralysis or limb loss could use cortical neuronal ..
  3. ncbi Control of fast-reaching movements by muscle synergy combinations
    Andrea d'Avella
    Department of Neuromotor Physiology, Santa Lucia Foundation, 00179 Rome, Italy
    J Neurosci 26:7791-810. 2006
    ..We recorded electromyographic activity from up to 19 shoulder and arm muscles during point-to-point movements between a central location and 8 peripheral targets in each of 2 vertical ..
  4. pmc Supplementary motor area exerts proactive and reactive control of arm movements
    Xiaomo Chen
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 30:14657-75. 2010
    ..The LFP power in high- (60-150 Hz) and low- (25-40 Hz) frequency bands was significantly correlated with arm movement reaction time, starting before target onset...
  5. pmc Effects of robot-assisted therapy on upper limb recovery after stroke: a systematic review
    Gert Kwakkel
    Department Rehabilitation Medicine and Research Institute MOVE, VU University Medical Center Amsterdam, The Netherlands
    Neurorehabil Neural Repair 22:111-21. 2008
    ..The aim of the study was to present a systematic review of studies that investigate the effects of robot-assisted therapy on motor and functional recovery in patients with stroke...
  6. ncbi Prediction of arm movement trajectories from ECoG-recordings in humans
    Tobias Pistohl
    Bernstein Center for Computational Neuroscience, Albert Ludwigs University, Freiburg, Germany
    J Neurosci Methods 167:105-14. 2008
    Electrocorticographic (ECoG) signals have been shown to contain reliable information about the direction of arm movements and can be used for on-line cursor control...
  7. ncbi Ambulatory measurement of arm orientation
    H J Luinge
    Xsens Technologies b v, Enschede, The Netherlands
    J Biomech 40:78-85. 2007
    ..In order to evaluate the impact of neuromuscular disorders affecting the upper extremities, the functional use of the arm need to be evaluated during daily activities...
  8. pmc Learning to control a brain-machine interface for reaching and grasping by primates
    Jose M Carmena
    Department of Neurobiology, Duke University, Durham, North Carolina, USA
    PLoS Biol 1:E42. 2003
    ..Here we demonstrate that primates can learn to reach and grasp virtual objects by controlling a robot arm through a closed-loop brain-machine interface (BMIc) that uses multiple mathematical models to extract several ..
  9. doi Deep brain stimulation of subthalamic nuclei affects arm response inhibition in Parkinson's patients
    G Mirabella
    Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, 86077 Pozzilli IS, Italy
    Cereb Cortex 22:1124-32. 2012
    ..does not cause a general improvement in task-related motor function as it does not affect the length of the reaction times of arm movements, that is, in our experimental context, STN seems to play a selective role in response inhibition.
  10. pmc Decoding complete reach and grasp actions from local primary motor cortex populations
    Carlos E Vargas-Irwin
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 30:9659-69. 2010
    How the activity of populations of cortical neurons generates coordinated multijoint actions of the arm, wrist, and hand is poorly understood...
  11. ncbi Persisting consequences of stroke measured by the Stroke Impact Scale
    Sue Min Lai
    Department of Preventive Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7313, USA
    Stroke 33:1840-4. 2002
    ....
  12. doi Differential representation of arm movement direction in relation to cortical anatomy and function
    Tonio Ball
    Epilepsy Center, University Clinic, Albert Ludwigs University, 79095 Freiburg, Germany
    J Neural Eng 6:016006. 2009
    Information about arm movement direction in neuronal activity of the cerebral cortex can be used for movement control mediated by a brain-machine interface (BMI)...
  13. ncbi Single-unit activity related to bimanual arm movements in the primary and supplementary motor cortices
    O Donchin
    Department of Physiology and the Center for Neural Computation, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel
    J Neurophysiol 88:3498-517. 2002
    ..were recorded from the primary motor (MI) and supplementary motor (SMA) areas of Rhesus monkeys performing one-arm (unimanual) and two-arm (bimanual) proximal reaching tasks...
  14. ncbi Quantifying generalization from trial-by-trial behavior of adaptive systems that learn with basis functions: theory and experiments in human motor control
    Opher Donchin
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Neurosci 23:9032-45. 2003
    ....
  15. ncbi Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. The Cardiovascular Health Study Group
    A B Newman
    University of Pittsburgh, Pittsburgh, PA, USA
    Arterioscler Thromb Vasc Biol 19:538-45. 1999
    Peripheral arterial disease (PAD) in the legs, measured noninvasively by the ankle-arm index (AAI) is associated with clinically manifest cardiovascular disease (CVD) and its risk factors...
  16. ncbi The Motor Activity Log-28: assessing daily use of the hemiparetic arm after stroke
    G Uswatte
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neurology 67:1189-94. 2006
    ..Before the Motor Activity Log (MAL) was developed, no instruments assessed spontaneous use of a hemiparetic arm outside the treatment setting.
  17. doi A randomized controlled trial of gravity-supported, computer-enhanced arm exercise for individuals with severe hemiparesis
    Sarah J Housman
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, Illinois 60660, USA
    Neurorehabil Neural Repair 23:505-14. 2009
    The authors previously developed a passive instrumented arm orthosis (Therapy Wilmington Robotic Exoskeleton [T-WREX]) that enables individuals with hemiparesis to exercise the arm by playing computer games in a gravity-supported ..
  18. ncbi A standardized approach to performing the action research arm test
    Nuray Yozbatiran
    Departments of Neurology and Anatomy, University of California, Irvine Medical Center, Orange, CA 92868 4280, USA
    Neurorehabil Neural Repair 22:78-90. 2008
    The study of stroke and its treatment in human subjects requires accurate measurement of behavioral status. Arm motor deficits are among the most common sequelae after stroke...
  19. ncbi Persistence of motor adaptation during constrained, multi-joint, arm movements
    R A Scheidt
    Department of Biomedical Engineering, Northwestern University, Evanston, IL 60622, USA
    J Neurophysiol 84:853-62. 2000
    ..associated with adaptation to a novel dynamic environment during goal-directed movements of the dominant arm. Eleven normal, human subjects made targeted reaching movements in the horizontal plane while holding the handle of ..
  20. ncbi Evidence for a dynamic-dominance hypothesis of handedness
    Robert L Sainburg
    Department of Kinesiology, The Pennsylvania State University, 266 Recreation Bldg, University Park, PA 16802, USA
    Exp Brain Res 142:241-58. 2002
    ..A recent study examining interlimb differences in coordination of reaching demonstrated dominant arm advantages in controlling limb segment inertial dynamics (Sainburg and Kalakanis 2000)...
  21. ncbi Multisensory integration during motor planning
    Samuel J Sober
    Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, and Neuroscience Graduate Program, University of California San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 23:6982-92. 2003
    When planning goal-directed reaches, subjects must estimate the position of the arm by integrating visual and proprioceptive signals from the sensory periphery...
  22. ncbi Robot-assisted movement training compared with conventional therapy techniques for the rehabilitation of upper-limb motor function after stroke
    Peter S Lum
    Rehabilitation Research and Development Center, VA Palo Alto Health Care System, Palo Alto, CA, USA
    Arch Phys Med Rehabil 83:952-9. 2002
    ..To compare the effects of robot-assisted movement training with conventional techniques for the rehabilitation of upper-limb motor function after stroke...
  23. ncbi Assessing Wolf motor function test as outcome measure for research in patients after stroke
    S L Wolf
    Division of Physical Therapy, Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Stroke 32:1635-9. 2001
    ..This study addresses selected psychometric attributes of the WMFT applied to a chronic stroke population...
  24. doi Arm motor recovery using a virtual reality intervention in chronic stroke: randomized control trial
    Sandeep K Subramanian
    McGill University, Montreal, Canada
    Neurorehabil Neural Repair 27:13-23. 2013
    Despite interest in virtual environments (VEs) for poststroke arm motor rehabilitation, advantages over physical environment (PE) training have not been established.
  25. doi The effects of arm swing on human gait stability
    Sjoerd M Bruijn
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University Van der Boechorststraat 9, NL 1081 BT, Amsterdam, The Netherlands
    J Exp Biol 213:3945-52. 2010
    b>Arm swing during human gait has been shown to reduce both angular momentum about the vertical and energy expenditure, and has been hypothesized to enhance gait stability...
  26. doi Sensor-based arm skill training in chronic stroke patients: results on treatment outcome, patient motivation, and system usability
    Annick A A Timmermans
    Department of Biomedical Technology, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands
    IEEE Trans Neural Syst Rehabil Eng 18:284-92. 2010
    ..was to evaluate patient motivation for and the feasibility and effects of a new technology-supported task-oriented arm training regime (T-TOAT)...
  27. doi Nature, timing, frequency and type of augmented feedback; does it influence motor relearning of the hemiparetic arm after stroke? A systematic review
    Birgit I Molier
    Roessingh Research and Development, 7500 AH Enschede, the Netherlands b molier rrd nl
    Disabil Rehabil 32:1799-809. 2010
    To investigate the effect of different aspects and types of augmented feedback on motor functions and motor activities of the hemiparetic arm after stroke.
  28. doi Psychosocial factors predicted nonrecovery in both specific and nonspecific diagnoses at arm, neck, and shoulder
    Ellen Keijsers
    Department of General Practice, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Epidemiol 63:1370-9. 2010
    To evaluate the differences in predictors of nonrecovery between patients with a specific diagnosis at arm, neck, and/or shoulder, vs. patients with a nonspecific diagnosis in general practice at 6 months after the first consultation.
  29. pmc Software-recorded and self-reported duration of computer use in relation to the onset of severe arm-wrist-hand pain and neck-shoulder pain
    Stefan IJmker
    Research Centre on Physical Activity, Work and Health, TNO VU VUmc, Amsterdam, The Netherlands
    Occup Environ Med 68:502-9. 2011
    ..The objective of this study was to examine the association between duration of computer use at work, measured with software and self-reports, and the onset of severe arm-wrist-hand and neck-shoulder symptoms.
  30. pmc Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients
    Nazanin Noori
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin J Am Soc Nephrol 5:2258-68. 2010
    ..We hypothesized that mid-arm muscle circumference (MAMC), a conveniently measured surrogate of lean body mass (LBM), has stronger association ..
  31. doi Hip velocity and arm coordination in front crawl swimming
    C Schnitzler
    Faculty of Sport Science from Rouen, Laboratory CETAPS UPRES EA 3832, University of Rouen, Faculty of Sports Sciences France, Mont Saint Aignan, France
    Int J Sports Med 31:875-81. 2010
    ..velocity variability and its stability over a range of swimming paces, which result from optimized inter-arm coordination, are characteristic of skilled performance...
  32. doi What's new in new technologies for upper extremity rehabilitation?
    Sylvain Brochard
    CHU Brest, Service de Medecine Physique et de Readaptation, Brest, France
    Curr Opin Neurol 23:683-7. 2010
    ..The review presents new trends and studies of effectiveness from recent literature regarding robots, virtual reality and telerehabilitation for neurorehabilitation of the upper limb...
  33. doi Cathodal transcranial direct current stimulation of the primary motor cortex improves selective muscle activation in the ipsilateral arm
    Alana B McCambridge
    Movement Neuroscience Laboratory, The University of Auckland, Auckland, New Zealand
    J Neurophysiol 105:2937-42. 2011
    ..These findings may have relevance for the use of tDCS in rehabilitation after stroke...
  34. pmc Technology-assisted training of arm-hand skills in stroke: concepts on reacquisition of motor control and therapist guidelines for rehabilitation technology design
    Annick A A Timmermans
    Faculty of Biomedical Technology, Technical University Eindhoven, Eindhoven, The Netherlands
    J Neuroeng Rehabil 6:1. 2009
    It is the purpose of this article to identify and review criteria that rehabilitation technology should meet in order to offer arm-hand training to stroke patients, based on recent principles of motor learning.
  35. ncbi Interstitial muscle lactate, pyruvate and potassium dynamics in the trapezius muscle during repetitive low-force arm movements, measured with microdialysis
    L Rosendal
    National Institute of Occupational Health, Copenhagen, Denmark
    Acta Physiol Scand 182:379-88. 2004
    ..Local muscle metabolic responses to repetitive low-force contractions and to intense static contractions were studied by microdialysis in humans...
  36. ncbi Endpoint stiffness of the arm is directionally tuned to instability in the environment
    David W Franklin
    National Institute of Information and Communications Technology, Keihanna Science City, Kyoto 619 0288, Japan
    J Neurosci 27:7705-16. 2007
    ..Furthermore, it supports the idea that the CNS incorporates an impedance controller that acts to ensure stability, reduce movement variability, and reduce metabolic cost...
  37. ncbi Movement-related potentials associated with self-paced, cued and imagined arm movements
    S K Jankelowitz
    Institute of Neurological Sciences and UNSW Clinical School, The Prince of Wales Hospital, Randwick, Sydney 2031, NSW, Australia
    Exp Brain Res 147:98-107. 2002
    ..In addition, in view of the greater SMA activation in association with proximal arm movements, we studied movements at multiple joints in the right arm. All the potentials were largest at Cz...
  38. ncbi Computerized arm training improves the motor control of the severely affected arm after stroke: a single-blinded randomized trial in two centers
    S Hesse
    Klinik Berlin, Neurological Rehabilitation, Charite, Berlin, Germany
    Stroke 36:1960-6. 2005
    To compare a computerized arm trainer (AT), allowing repetitive practice of passive and active bilateral forearm and wrist movement cycle, and electromyography-initiated electrical stimulation (ES) of the paretic wrist extensor in ..
  39. doi Cortical control of a prosthetic arm for self-feeding
    Meel Velliste
    Department of Neurobiology, School of Medicine, E1440 BST, Lothrop Street, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nature 453:1098-101. 2008
    b>Arm movement is well represented in populations of neurons recorded from the motor cortex...
  40. ncbi Voluntary modification of automatic arm movements evoked by motion of a visual target
    B L Day
    MRC Human Movement and Balance Unit, Institute of Neurology, London, UK
    Exp Brain Res 130:159-68. 2000
    ..to a reach are: (1) modifiable by the subject's intention, and (2) available to initiate movement of a stationary arm. Unpredictable movement of a target (80 m/s through 10 cm, left or right in a third of trials) either evoked a mid-..
  41. pmc Cortical representation of ipsilateral arm movements in monkey and man
    Karunesh Ganguly
    Department of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, California 94720, USA
    J Neurosci 29:12948-56. 2009
    ..neurons in primary motor cortex (M1) may represent, on average, the direction of movements of the ipsilateral arm. Given the increasing body of evidence demonstrating that neural ensembles can reliably represent information with ..
  42. doi Neck Disability Index, short form-36 physical component summary, and pain scales for neck and arm pain: the minimum clinically important difference and substantial clinical benefit after cervical spine fusion
    Leah Y Carreon
    Norton Leatherman Spine Center, 210 East Gray St, Suite 900, Louisville, KY 40202, USA
    Spine J 10:469-74. 2010
    The Neck Disability Index (NDI), the short form-36 (SF-36) physical component summary (PCS), and pain scales for arm and neck pain are increasingly used to evaluate treatment effectiveness after cervical spine surgery...
  43. ncbi Web-based telerehabilitation for the upper extremity after stroke
    David J Reinkensmeyer
    Department of Mechanical and Aerospace Engineering, Center for Biomedical Engineering, University of California, Irvine 92697 3975, USA
    IEEE Trans Neural Syst Rehabil Eng 10:102-8. 2002
    ..This paper provides a detailed design description of a telerehabilitation system for arm and hand therapy following stroke...
  44. doi Virtual reality in the rehabilitation of the arm after hemiplegic stroke: a randomized controlled pilot study
    J H Crosbie
    Neurological Physiotherapist, Belfast, UK
    Clin Rehabil 26:798-806. 2012
    ..the effectiveness of virtual reality-mediated therapy compared to conventional physiotherapy in the motor rehabilitation of the arm following stroke, and to provide data for a power analysis to determine numbers for a future main trial.
  45. ncbi Robot-aided neurorehabilitation of the upper extremities
    R Riener
    Rehabilitation Engineering Group, Automatic Control Laboratory, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Med Biol Eng Comput 43:2-10. 2005
    ..The devices are critically compared with respect to technical function, clinical applicability, and, if they exist, clinical outcomes...
  46. pmc Robotically facilitated virtual rehabilitation of arm transport integrated with finger movement in persons with hemiparesis
    Alma S Merians
    Department of Rehabilitation and Movement Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    J Neuroeng Rehabil 8:27. 2011
    Recovery of upper extremity function is particularly recalcitrant to successful rehabilitation. Robotic-assisted arm training devices integrated with virtual targets or complex virtual reality gaming simulations are being developed to ..
  47. ncbi MIME robotic device for upper-limb neurorehabilitation in subacute stroke subjects: A follow-up study
    Peter S Lum
    Hunter Holmes McGuire Department of Veterans Affairs VA Medical Center, Richmond, VA, USA
    J Rehabil Res Dev 43:631-42. 2006
    ..Robot-assisted treatment gains exceeded those expected from spontaneous recovery. These results are discussed in light of the need for further device development and continued clinical trials...
  48. pmc Waist circumference and mid-upper arm circumference in evaluation of obesity in children aged between 6 and 17 years
    M Mumtaz Mazicioglu
    Department of Family Medicine, School of Medicine, Erciyes University, Kayseri, Turkey
    J Clin Res Pediatr Endocrinol 2:144-50. 2010
    The purpose of this study was to determine the cut-off values for waist circumference (WC) and mid-upper arm circumference (MUAC) and to assess their use in screening for obesity in children.
  49. pmc Spontaneous synchronization of arm motion between Japanese macaques
    Yasuo Nagasaka
    Laboratory for Adaptive Intelligence, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Sci Rep 3:1151. 2013
    ..This study establishes advanced tasks for testing social coordination in monkeys, and illustrates ways in which monkeys coordinate their actions to establish synchronization...
  50. ncbi Cerebellar complex spikes encode both destinations and errors in arm movements
    S Kitazawa
    Information Science Division, Electrotechnical Laboratory, Japan Science and Technology Corporation, Tsukuba
    Nature 392:494-7. 1998
    ..complex spikes, named after the complexity of their waveforms, with a frequency of approximately 1 Hz during arm movements...
  51. ncbi The central nervous system stabilizes unstable dynamics by learning optimal impedance
    E Burdet
    Department of Mechanical Engineering, National University of Singapore, 119260, Singapore
    Nature 414:446-9. 2001
    ..Stability may be dependent on the control of mechanical impedance in the human arm because mechanical impedance can generate forces which resist destabilizing motion...
  52. pmc Effect of arm position on the prediction of kinematics from EMG in amputees
    Ning Jiang
    Department of Neurorehabilitation Engineering, Bernstein Focus Neurotechnology Göttingen, Bernstein Center for Computational Neuroscience, University Medical Center Gottingen, Gottingen, Germany
    Med Biol Eng Comput 51:143-51. 2013
    ..One of these factors is the change in arm posture during the daily use of prostheses...
  53. doi Three-dimensional, task-specific robot therapy of the arm after stroke: a multicentre, parallel-group randomised trial
    Verena Klamroth-Marganska
    Sensory Motor Systems Lab, Institute of Robotics and Intelligent Systems, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland Electronic address
    Lancet Neurol 13:159-66. 2014
    b>Arm hemiparesis secondary to stroke is common and disabling...
  54. ncbi Intensity of leg and arm training after primary middle-cerebral-artery stroke: a randomised trial
    G Kwakkel
    Department of Physical Therapy and Research Institute for Fundamental and Clinical Human Movement Sciences, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Lancet 354:191-6. 1999
    We investigated the effects of different intensities of arm and leg rehabilitation training on the functional recovery of activities of daily living (ADL), walking ability, and dexterity of the paretic arm, in a single-blind randomised ..
  55. ncbi Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex
    J K Chapin
    Department of Neurobiology and Anatomy, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Nat Neurosci 2:664-70. 1999
    ..recorded motor cortex neurons can be used for real-time device control, rats were trained to position a robot arm to obtain water by pressing a lever...
  56. ncbi The development toward stereotypic arm kinematics during reaching in the first 3 years of life
    J Konczak
    Department of Neurology, University of Tubingen, Germany
    Exp Brain Res 117:346-54. 1997
    ..Here we analyze hand and proximal joint trajectories and examine the emerging temporal coordination between arm segments...
  57. ncbi Role of cocontraction in arm movement accuracy
    Paul L Gribble
    Department of Psychology, Graduate Program in Neuroscience, The University of Western Ontario, London, Canada
    J Neurophysiol 89:2396-405. 2003
    ..energetically expensive, cocontraction may be a strategy used by the motor system to facilitate multi-joint arm movement accuracy...
  58. ncbi Prediction of arm trajectory from a small number of neuron activities in the primary motor cortex
    Yasuharu Koike
    Core Research for Evolution Science and Technology CREST, Japan Science an Technology Agency, Kawaguchi 332 0012, Japan
    Neurosci Res 55:146-53. 2006
    Monkey arm movement was reconstructed from neuron activities recorded in the primary motor cortex (Ml). We recorded single neuron activities from a monkey's Ml, while the animal performed an arm reaching task...
  59. ncbi Effects of altering initial position on movement direction and extent
    Robert L Sainburg
    Department of Kinesiology, The Pennsylvania State University, University Park 16802, USA
    J Neurophysiol 89:401-15. 2003
    ..Subjects performed a horizontal-plane reaching task with the dominant arm supported above a table top by a frictionless air-jet system...
  60. ncbi Repetitive bilateral arm training with rhythmic auditory cueing improves motor function in chronic hemiparetic stroke
    J Whitall
    Departments of Physical Therapy, School of Medicine, University of Maryland at Baltimore, USA
    Stroke 31:2390-5. 2000
    ..We investigated the hypothesis that bilateral arm training with rhythmic auditory cueing (BATRAC) will improve motor function in the hemiparetic arm of stroke ..
  61. pmc Impact of botulinum toxin type A on disability and carer burden due to arm spasticity after stroke: a randomised double blind placebo controlled trial
    B B Bhakta
    Rheumatology and Rehabilitation Research Unit, University of Leeds, 36 Clarendon Road, Leeds LS2 9NZ, UK
    J Neurol Neurosurg Psychiatry 69:217-21. 2000
    After stroke, abnormal arm posture due to spasticity in a functionally useless arm may interfere with self care tasks. In these patients botulinum toxin treatment presents an opportunity to reduce disability...
  62. ncbi Concurrent adaptations of left and right arms to opposite visual distortions
    Otmar Bock
    Institute of Physiology and Anatomy, German Sport University, 50927 Koln, Germany
    Exp Brain Res 162:513-9. 2005
    Previous research has shown that subjects can adapt with either arm to an opposite visual distortion, and the two adaptive states can then be used in sequence to control the respective arm...
  63. doi Training-induced changes in the pattern of triceps to biceps activation during reaching tasks after chronic and severe stroke
    Ruth Nancy Barker
    Discipline of Physiotherapy, James Cook University, Townsville, Australia
    Exp Brain Res 196:483-96. 2009
    ..who completed the study, 10 received training of reaching using a non-robotic upper limb training device, the SMART Arm, with EMG triggered functional electrical stimulation (EMG-stim), 13 received training of reaching using the SMART ..
  64. ncbi Effects of arm exercise on serum glucose response in type 2 DM patients
    Chii Jeng
    School of Nursing, Taipei Medical University
    J Nurs Res 10:187-94. 2002
    ..Thirty-three type 2 DM patients who met the selection criteria were selected. An arm cycle ergometer exercise test was conducted, and then 12 arm exercise sessions were arranged based on different ..
  65. ncbi The ABILHAND questionnaire as a measure of manual ability in chronic stroke patients: Rasch-based validation and relationship to upper limb impairment
    M Penta
    Rehabilitation and Physical Medicine Unit, , Brussels, Belgium
    Stroke 32:1627-34. 2001
    ..patients often retain the ability to manage activities requiring both hands, either through the use of the affected arm or compensation with the unaffected limb...
  66. doi Langerhans cell sarcoma emanating from the upper arm skin: successful treatment by MAID regimen
    Kenzo Uchida
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Matsuoka, Fukui, Japan
    J Orthop Sci 13:89-93. 2008
  67. doi The influence of predicted arm biomechanics on decision making
    Ignasi Cos
    Departement de Physiologie, Universite de Montreal, Montreal, QC, Canada
    J Neurophysiol 105:3022-33. 2011
    ..in our task, subjects preferred movements whose final trajectory was better aligned with the major axis of the arm's mobility ellipse, even when the launching properties were very similar...
  68. ncbi Reverse correlation between ankle-brachial index and left ventricular hypertrophy in patients on maintenance haemodialysis
    Wencheng Fu
    Department of Nephrology, Center of Kidney Disease, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Nephrology (Carlton) 11:9-14. 2006
    ..Ankle-brachial index (ABI) has been recently demonstrated to be a predictor for all-cause and cardiovascular mortality in MHD Patients. The main objective of the present study is to see whether ABI is correlated with LVH in MHD patients...
  69. ncbi The incidence of arm edema in women with breast cancer randomized on the National Surgical Adjuvant Breast and Bowel Project study B-04 to radical mastectomy versus total mastectomy and radiotherapy versus total mastectomy alone
    Melvin Deutsch
    National Surgical Adjuvant Breast and Bowel Project NSABP Operations and Biostatistical Centers, University of Pittsburgh Medical Center, Department of Radiation Oncology, Pittsburgh, PA, USA
    Int J Radiat Oncol Biol Phys 70:1020-4. 2008
    To determine the incidence and factors associated with the development of arm edema in women who participated in the National Surgical Adjuvant Breast and Bowel Project (NSABP) study B-04.
  70. doi Assessment of upper-limb sensorimotor function of subacute stroke patients using visually guided reaching
    Angela M Coderre
    Queen s University, Kingston, ON, Canada
    Neurorehabil Neural Repair 24:528-41. 2010
    ..Using robotic technology, we examined the ability of a visually guided reaching task to assess the sensorimotor function of patients with stroke...
  71. doi Mentally represented motor actions in normal aging: III. Electromyographic features of imagined arm movements
    Pascaline Personnier
    Universite de Bourgogne, UFR STAPS, Institut National de la Sante et de la Recherche Medicale INSERM, Unité 887, Motricité et Plasticité, BP 27877, F 21078 Dijon, France
    Behav Brain Res 206:184-91. 2010
    ..Here, we investigated the temporal and electromyographic (EMG) features of imagined arm movements in healthy elderly adults. Twelve young (mean age: 24.0+/-1.3 years) and 12 elderly (mean age: 67.0+/-4...
  72. pmc Continuous neuronal ensemble control of simulated arm reaching by a human with tetraplegia
    E K Chadwick
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
    J Neural Eng 8:034003. 2011
    ..electrical stimulation (FES), the coordinated electrical activation of multiple muscles, has been used to restore arm and hand function in people with paralysis...
  73. pmc Cerebellar inputs to intraparietal cortex areas LIP and MIP: functional frameworks for adaptive control of eye movements, reaching, and arm/eye/head movement coordination
    Vincent Prevosto
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR9040 CNRS, 1 Av de la Terrasse, Gif sur Yvette, France
    Cereb Cortex 20:214-28. 2010
    ..Area MIP is the target of projections from the ventral D (mainly middle third), and gaze- and arm-related domains of IP involved in reaching and arm/eye/head coordination...
  74. pmc The relation between arm/shoulder problems and quality of life in breast cancer survivors: a cross-sectional and longitudinal study
    Inger Lise Nesvold
    National Resource Center for Late Effects, Department of Oncology, Oslo University Hospital and University of Oslo, Oslo, Norway
    J Cancer Surviv 5:62-72. 2011
    This cross-sectional and longitudinal study of breast cancer survivors (BCSs) examines the associations between arm/shoulder problems (ASPs), which consist of pain, restricted mobility and lymphedema, and different aspects of quality of ..
  75. pmc Visuomotor learning generalizes between bilateral and unilateral conditions despite varying degrees of bilateral interference
    Jinsung Wang
    Department of Human Movement Sciences, 491 Enderis Hall, University of Wisconsin, Milwaukee, WI 53201, USA
    J Neurophysiol 104:2913-21. 2010
    Bilateral interference, referring to the tendency of movements of one arm to disrupt the intended movements made simultaneously with the other arm, is often observed in a task that involves differential planning of each arm movement ..
  76. pmc Bilateral and unilateral arm training improve motor function through differing neuroplastic mechanisms: a single-blinded randomized controlled trial
    Jill Whitall
    Department of Physical Therapy and Rehabilitation Science, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Neurorehabil Neural Repair 25:118-29. 2011
    This randomized controlled trial tests the efficacy of bilateral arm training with rhythmic auditory cueing (BATRAC) versus dose-matched therapeutic exercises (DMTEs) on upper-extremity (UE) function in stroke survivors and uses ..
  77. ncbi Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection
    Claude Nos
    Department of Gynecologic and Oncologic Surgery, Hopital Europeen Georges Pompidou, Paris, France
    Ann Surg Oncol 14:2490-6. 2007
    ..many patients with invasive breast cancer still undergo an axillary lymph node dissection and are at risk of arm lymphedema...
  78. pmc The illusion of owning a third arm
    Arvid Guterstam
    Brain, Body and Self Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e17208. 2011
    ..that, in the not-so-distant future, we will be able to reshape the human body so as to have extra limbs? A third arm helping us out with the weekly shopping in the local grocery store, or an extra artificial limb assisting a ..
  79. pmc Population-based cohort study of incident and persistent arm pain: role of mental health, self-rated health and health beliefs
    K T Palmer
    MRC Epidemiology Resource Centre, Community Clinical Sciences, University of Southampton, Southampton General Hospital, Southampton, England SO16 6YD, UK
    Pain 136:30-7. 2008
    To investigate whether somatising tendency, low mood and poor self-rated health (SRH) predict incident arm pain, and whether these factors and beliefs about causation and prognosis predict symptom persistence, we conducted an 18-month ..
  80. pmc Evidence for composite cost functions in arm movement planning: an inverse optimal control approach
    Bastien Berret
    Italian Institute of Technology, Department of Robotics, Brain and Cognitive Sciences, Genoa, Italy
    PLoS Comput Biol 7:e1002183. 2011
    ..In order to better clarify this last point, we consider an innovative experimental paradigm characterized by arm reaching with target redundancy...
  81. ncbi Influence of obesity on accurate and rapid arm movement performed from a standing posture
    F Berrigan
    Groupe de Recherche en Analyse du Mouvement et Ergonomie GRAME, Quebec, Canada
    Int J Obes (Lond) 30:1750-7. 2006
    ..This study sought to examine if obesity imposes an additional balance control constraint limiting the speed and accuracy with which an upper limb goal-directed movement performed from an upright standing position can be executed...
  82. pmc The influence of target sensory modality on motor planning may reflect errors in sensori-motor transformations
    F R Sarlegna
    Department of Kinesiology, The Pennsylvania State University, PA, USA
    Neuroscience 164:597-610. 2009
    ..Here we investigated the effect of visuo-proprioceptive integration on the control of multi-joint arm movements by manipulating target modality...
  83. ncbi Bilateral actions of the reticulospinal tract on arm and shoulder muscles in the monkey: stimulus triggered averaging
    Adam G Davidson
    Neuroscience Graduate Studies Program, The Ohio State University, 1583 Perry Street, Rm 516G, Columbus, OH 43210, USA
    Exp Brain Res 173:25-39. 2006
    ..muscles of both upper limbs while two awake monkeys (Macaca fascicularis) performed a reaching task using either arm. Extensor and flexor muscles were studied at the wrist, elbow, and shoulder; muscles acting on the scapula were ..
  84. pmc Cerebellum predicts the future motor state
    Timothy J Ebner
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Cerebellum 7:583-8. 2008
    ..However, Purkinje cell firing has several of the characteristics of a forward internal model of the arm. A synthesis of the evidence suggests that the cerebellum is involved in integrating the current state of the motor ..
  85. pmc Strategies for stroke rehabilitation
    Bruce H Dobkin
    Neurologic Rehabilitation and Research Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, USA
    Lancet Neurol 3:528-36. 2004
    ..Biological strategies for neural repair may augment rehabilitation in the next decade...
  86. ncbi Comparison of two techniques of robot-aided upper limb exercise training after stroke
    Joel Stein
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts 02114, USA
    Am J Phys Med Rehabil 83:720-8. 2004
    ..This study examined whether incorporating progressive resistive training into robot-aided exercise training provides incremental benefits over active-assisted robot-aided exercise for the upper limb after stroke...
  87. ncbi Impact of time on improvement of outcome after stroke
    Gert Kwakkel
    Department of Rehabilitation, VU University Medical Centre and Rehabilitation Centre De Hoogstraat, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, The Netherlands
    Stroke 37:2348-53. 2006
    ..The aim of the present study was to study the effects of progress of time on observed improvements in motor strength, synergisms, and activities during the first 16 weeks poststroke...
  88. doi Cortical control of arm movements: a dynamical systems perspective
    Krishna V Shenoy
    Department of Electrical Engineering, Stanford Institute for Neuro Innovation and TranslationalNeuroscience, Stanford University, Stanford, CA 94305, USA
    Annu Rev Neurosci 36:337-59. 2013
    ..Investigating the neural control of movement in general, and the cortical control of volitional arm movements in particular, has been a major research focus in recent decades...
  89. pmc Impedance control and internal model use during the initial stage of adaptation to novel dynamics in humans
    Theodore E Milner
    ATR Computational Neuroscience Laboratories, Keihanna Science City, Kyoto, Japan
    J Physiol 567:651-64. 2005
    ..Feedforward cocontraction of all muscles was used to increase the viscoelastic impedance of the arm. While stiffening the arm, subjects also exerted a lateral force to counteract the perturbing effect of the force ..
  90. ncbi Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise
    Nikolai Nordsborg
    The August Krogh Institute, IFI, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 285:R143-8. 2003
    ..human skeletal muscle by microdialysis during exhaustive leg exercise, with (AL) and without (L) previous intense arm exercise. In addition, the reproducibility of the [K+]i determinations was examined...
  91. ncbi Effects of robotic therapy on motor impairment and recovery in chronic stroke
    Susan E Fasoli
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Arch Phys Med Rehabil 84:477-82. 2003
    To examine whether robotic therapy can reduce motor impairment and enhance recovery of the hemiparetic arm in persons with chronic stroke.
  92. ncbi Assessing mechanisms of recovery during robot-aided neurorehabilitation of the upper limb
    R Colombo
    Salvatore Maugeri Foundation, IRCCS, Service of Bioengineering Veruno NO, Italy
    Neurorehabil Neural Repair 22:50-63. 2008
    ..The present study aimed to qualify and quantify the different components of motor recovery in a group of stroke patients treated by robot-aided techniques. In addition, the learning model of each motor recovery component was analyzed...
  93. doi Influence of task-oriented training content on skilled arm-hand performance in stroke: a systematic review
    Annick A A Timmermans
    Eindhoven University of Technology, Eindhoven, Netherlands
    Neurorehabil Neural Repair 24:858-70. 2010
    This review evaluates the underlying training components currently used in task-oriented training and assesses the effects of these components on skilled arm-hand performance in patients after a stroke.
  94. ncbi Robot-based hand motor therapy after stroke
    Craig D Takahashi
    Department of Neurology, University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868 4280, USA
    Brain 131:425-37. 2008
    ..Subjects with chronic stroke producing moderate right arm/hand weakness received 3 weeks therapy that emphasized intense active movement repetition as well as attention, ..
  95. ncbi The dominant and nondominant arms are specialized for stabilizing different features of task performance
    Jinsung Wang
    Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    Exp Brain Res 178:565-70. 2007
    ..During aimed movements, the dominant arm shows advantages for coordinating intersegmental dynamics as required for specifying trajectory speed and direction,..
  96. ncbi Role of limb and target vision in the online control of memory-guided reaches
    Matthew Heath
    Dept of Kinesiology and Program in Neural Science, Indiana University, Bloomington, Indiana 47405, USA
    Motor Control 9:281-311. 2005
    ..It is therefore proposed that a reasonably accurate and temporally stable stored target representation can be combined with vision of the moving limb for the online control of memory-guided reaches...
  97. pmc Somatosensory plasticity and motor learning
    David J Ostry
    McGill University, Montreal, Quebec H3A 1B1, Canada
    J Neurosci 30:5384-93. 2010
    ..The findings indicate that motor learning affects not only motor areas of the brain but changes sensory function as well...
  98. ncbi Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial
    Robert E Mansel
    Department of Surgery, Cardiff University, Cardiff, UK
    J Natl Cancer Inst 98:599-609. 2006
    ....
  99. doi Risk factors for arm lymphedema following breast cancer diagnosis in Black women and White women
    Kathleen A Meeske
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Breast Cancer Res Treat 113:383-91. 2009
    Purpose Lymphedema of the arm is a potential complication of breast cancer therapy...
  100. doi Concurrent adaptation of force and impedance in the redundant muscle system
    Keng Peng Tee
    Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore
    Biol Cybern 102:31-44. 2010
    ..Simulations of multijoint arm movements with a neuromuscular plant that incorporates neural delays, reflexes, and signal-dependent noise, ..
  101. pmc Reaching activity in parietal area V6A of macaque: eye influence on arm activity or retinocentric coding of reaching movements?
    Nicoletta Marzocchi
    Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, I 40126 Bologna, Italy
    Eur J Neurosci 27:775-89. 2008
    ..area V6A contains neurons modulated by the direction of gaze as well as neurons able to code the direction of arm movement...

Research Grants76

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..The hair will be collected from the back of the head, and the skin will be collected from the inside of the upper arm. Title: A Pilot Phase I/II Study for the Evaluation of Dextromethorphan as a Microglia Inhibitor in the Treatment ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..The hair will be collected from the back of the head, and the skin will be collected from the inside of the upper arm. Title: A Pilot Phase I/II Study for the Evaluation of Dextromethorphan as a Microglia Inhibitor in the Treatment ..
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  5. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2013
    ..provided by applicant): The testis-specific protein Y-encoded (TSPY) gene is a tandemly repeated gene on the short arm of the human Y chromosome. Its 2...
  6. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..To test this hypothesis, we propose a double-blind randomized, placebo-controlled, five-arm pilot study which includes a dose ranging component in patients with T2DM and established nephropathy...
  7. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..well as SIV vaccine studies in monkeys suggest that it is unlikely that vaccine approaches that stimulate a single arm of the immune system will provide effective protection from viral infection...
  8. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..Life style, dietary and risk factor information was collected from participants. The intervention arm received for lung cancer, posterior-anterior (PA) chest x-ray annually for four screens (except never smokers who ..
  9. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..Life style, dietary and risk factor information was collected from participants. The intervention arm received for lung cancer, posterior-anterior (PA) chest x-ray annually for four screens (except never smokers who ..
  10. Behavioral Activation Therapy for Rural Veterans with Diabetes and Depression
    Aanand Dinkar Naik; Fiscal Year: 2013
    ..factors that mediate or moderate effectiveness at 6 and 12 months for patients enrolled in the HOPE intervention arm. Intervention factors include adherence (e.g...
  11. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    ..We will also identify lung diseases which will pre-dispose for the development of Abs to self-Ags. Control arm for this pilot clinical trial will be patients who currently participate in an ongoing clinical trial of Ab ..
  12. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..Specific Aim 2 is to examine if changes in ESH levels are associated with changes in glucose by intervention arm. Specific Aim 3 is to examine whether changes in adiposity, insulin sensitivity, and insulin secretion explain ..
  13. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..suffer from degeneration of the peripheral nerves that control sensory information of the foot/leg and hand/arm. The nerve degeneration causes the subsequent degeneration of the muscles in the extremities...
  14. Characterizing TLR Function of Human Dendritic Cells in the Elderly
    Alexander Panda; Fiscal Year: 2012
    ..Our research focuses on defects of the innate immunity arm in older adults and, ultimately, we hope that our work will help explain the deterioration of immunity seen in ..
  15. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..To test this hypothesis, we propose a double-blind randomized, placebo-controlled, five-arm pilot study which includes a dose ranging component in patients with T2DM and established nephropathy...
  16. UNDERSTANDING VIBRATION INJURY
    Danny A Riley; Fiscal Year: 2013
    ..manufacturing, agriculture-forestry and fishing, and mining Sectors and are currently exposed to levels of hand-arm vibration putting them at risk for developing hand-arm vibration syndrome (HAVS) with a prevalence of 10-50% after ..
  17. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..pathologic readout of passively acquired autoimmunity, provides an exceptional opportunity to examine the effector arm of immunity and define the mechanism whereby an Ab mediates fibrosis, which is particularly aberrant in fetal ..
  18. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..DESIGN: This is a randomized, double-blind, placebo-controlled, parallel-arm, feasibility study...
  19. The Role of the Terminal Complement Pathway in ALS
    Scott R Barnum; Fiscal Year: 2013
    ..The complement system, a major arm of the innate immune system, drives neuroinflammation along with other inflammatory mediators in most, if not all, ..
  20. Arm Exercise versus Other Stress Test Modalities for Clinical Outcome Prediction
    WADE HAMPTON MARTIN; Fiscal Year: 2013
    ..The major hypothesis of this project is that composite findings of arm ergometer exercise ECG stress testing, with selective myocardial perfusion imaging (MPI) in a subset of patients ..
  21. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2012
    ..B1a B-cells are a critical arm of the innate immune system and provides the first line of defense against a variety of bacterial and viral ..
  22. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..HSCT as the control and R-BEAM or Bexxar/BEAM + autologous HSCT + lenalidomide maintenance as the experimental arm (2:1 randomization). 3) To analyze the results according to the germinal center type (GOB) vs...
  23. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2011
    ..Nab-paclitaxel, a FDA approved nanoparticle formulation of paclitaxel forms the systemic therapeutic arm. We will use a hyperspectral fluorescence microscope capable of non-invasively imaging BPD and ICG for simultaneous,..
  24. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..Preliminary calculations suggest that ~200 subjects in each treatment arm would provide us with reasonable power to detect a clinically meaningful and achievable reduction in GFR decline in ..
  25. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..cervical SCI a natural and volitionally controlled FES command interface for regaining functional control of the arm and hand...
  26. Complement Activation on Neisseria meningitidis
    Sanjay Ram; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Complement (C) is a key arm of innate immune defenses against invasive meningococcal infections. Neisseria meningitidis (Nm) have evolved several sophisticated mechanisms to evade host C...
  27. Planning Grant for the Efficacy of Auranofin for the Treatment of Amebiasis
    Sharon L Reed; Fiscal Year: 2012
    ..Our proposed clinical trial is a Phase IIa, 3 parallel arm, randomized, double blin treatment study comparing an active control (metronidazole) to once or twice daily doses ..
  28. Molecular Analysis of Pericentric Sister Chromatid Cohesion
    PAUL CONNOR MEGEE; Fiscal Year: 2013
    ..association of the RSC ATP-dependent chromatin remodeler, Scc2/Scc4, and cohesin will be determined at chromosome arm cohesin-associated regions to dissect the pathway for cohesin deposition...
  29. Identification of Biomarkers for Early Detection of Renal Cell Carcinoma
    Othon Iliopoulos; Fiscal Year: 2012
    ..For example, the duration of treatment for small molecule inhibitors, patient crossover among arms in multi-arm clinical trials, testing of rational combinations of small molecules, and selection of patients for adjuvant ..
  30. Regulatory targets and pathogenic mechanisms of anthrax edema factor
    Jin Mo Park; Fiscal Year: 2011
    ..the mechanisms by which anthrax bacteria manipulate macrophages, major cell participants in the first-strike arm of the immune system, disturbing the signaling system and commandeering the cells as transport, thus allowing the ..
  31. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2013
    ..Nab-paclitaxel, a FDA approved nanoparticle formulation of paclitaxel forms the systemic therapeutic arm. We will use a hyperspectral fluorescence microscope capable of non-invasively imaging BPD and ICG for simultaneous,..
  32. Inhibiting EGFR and ER pathways in NSCLC
    Edward B Garon; Fiscal Year: 2013
    ..The primary objective of the study is to determine the response rate in each arm. Secondary objectives include progression-free survival, overall survival and safety...
  33. C3, CR1, CRRY: INTERACTIONS, HOMEOSTASIS AND TRANSLATIONAL IMPLICATIONS
    JOHN PATTERSON ATKINSON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The complement system is a major player in innate immunity and an effector arm of the humoral immune response...
  34. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..Data obtained will include socioeconomic status, anthropometric data (weight, length, head circumference, and arm anthropometries), dietary intake (including breastfeeding duration and frequency), hemoglobin, ferritin...
  35. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    ..This involves both a "LLO biosynthetic" arm and a counter-intuitive "LLO degradative" arm...
  36. Acupuncture for Aromatase Inhibitor-Related Arthralgias in Breast Cancer Patients
    Dawn Hershman; Fiscal Year: 2013
    ..for 6 weeks follow by maintenance weekly acupuncture or sham acupuncture for 6 weeks or to a wait list control arm. True acupuncture sessions will consists of standardized full body and joint specific point prescription and the ..
  37. Nonheme Diiron Centers and the Biological Oxidation of Hydrocarbons
    Stephen J Lippard; Fiscal Year: 2013
    ..macrocycles and dendrimer sheaths as well as from a novel strategy that employs a pendant bridging carboxylate arm. Because of their ability to degrade hydrocarbons, BMMs have been applied for the bioremediation of contaminated ..
  38. Translational Diebetes Prevention in GDM
    Assiamira Ferrara; Fiscal Year: 2013
    ..Women will be randomly assigned to lifestyle intervention or usual medical care (175 in each arm)...
  39. Integrated Treatment for Smoking Cessation &Anxiety in People with HIV
    Michael J Zvolensky; Fiscal Year: 2013
    ..During the following two years, a small two-arm efficacy study (N = 60) will be undertaken comparing the new intervention to a control intervention...
  40. Surgical Indirect Revascularization For Symptomatic Intracranial Aterial Stenosis
    Nestor Gonzalez; Fiscal Year: 2013
    ..2% in the intensive medical therapy arm. The incidence of recurrence stroke can be even higher in some high-risk groups, as high as 25% in African-..
  41. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..on brain function and behavior and yield valuable information on neuroimmune mechanisms involving the adaptive arm of the immune response...
  42. Biomedical Computing Support of Cancer Control and Surveillance
    DAVID RONEY; Fiscal Year: 2009
    ..The DCCPS is the arm of the National Cancer Institute that both generates new knowledge and seeks to ensure that the products of cancer ..
  43. PERL: A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2013
    ..size calculations under various dropout and non- adherence scenarios suggest that 240 subjects in each treatment arm would provide at least 80% power to detect a clinically meaningful and achievable reduction in GFR decline in the ..
  44. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine A Curcio; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The clinical management of patients with age-related maculopathy (ARM) has been revolutionized by non-invasive imaging of the retina at near-histological detail...
  45. Immune activation by cetuximab in head and neck cancer patients
    Robert L Ferris; Fiscal Year: 2013
    ..Thus, we hypothesize that the cellular arm of the immune system plays an important role in mediating the anti-tumor effects of cetuximab...
  46. Causes of rotavirus vaccine failure in Zambian children
    Roma Chilengi; Fiscal Year: 2013
    ..infection both in mothers and infants, vitamin A and zinc deficiency, weight for age Z-scores as well as mid upper arm circumference will also be assessed...
  47. GRAFT REJECTION AND DIRECT VERSUS INDIRECT RECOGNITION
    PETER SCOTT HEEGER; Fiscal Year: 2013
    ..In addition to acting as an effector arm of antibody initiated injury to a transplant, graft-derived complement impacts ischemia reperfusion injury, ..
  48. Persistent microRNA changes in serum of cancer-free breast cancer patients
    Harikrishna Nakshatri; Fiscal Year: 2012
    ..The circulating microRNAs may be the invisible long-arm of cancer that reaches distant organs as circulating microRNAs can fuse with heterotypic cells and influence gene ..
  49. MECHANISM OF ACTION OF A MAJOR FOLATE ENZYME
    Sergey A Krupenko; Fiscal Year: 2013
    ..This flexible long arm is covalently attached to the enzyme, transferring the reaction intermediate between two catalytic sites, and its ..
  50. A randomized trial of bariatric surgery for the treatment of sleep apnea
    Sanjay R Patel; Fiscal Year: 2013
    ..e., in the OSA arm, while using CPAP in a controlled environment vs...
  51. Effects of prenatal stress exposure on childhood physical and metabolic outcomes
    Kelsey Needham Dancause; Fiscal Year: 2013
    ..I will collect detailed anthropometric measurements (height;weight;waist, hip, mid-upper-arm, and calf circumference;and triceps, subscapular, and suprailiac skinfolds) among Iowa Flood Study participants at ..
  52. Effect of botulinum toxin plus vibration on bone in children with cerebral palsy
    Christopher M Modlesky; Fiscal Year: 2012
    ..A pilot therapeutic trial with two randomized treatment arms (Botox and Botox + HLV) and a convenience control arm of children with CP (5 - 11 y) will be used to accomplish the aims...
  53. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The long-term goal of this project is to restore arm and hand function to people paralyzed below the neck due to a spinal cord injury...
  54. Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial
    Anil Sapru; Fiscal Year: 2013
    ..We will correlate changes over time in the biomarkers with allocation to treatment arm to test whether the beneficial effects of TGC-NL are achieved via normalization of coagulation and fibrinolysis...
  55. Quercetin to enhance the bioavailability and activity of green tea polyphenols
    SUSANNE MARGARETE HENNING; Fiscal Year: 2013
    ..We therefore propose a placebo- controlled, double-blinded, randomized, parallel two arm human pilot intervention study to determine whether the consumption of GT extract and quercetin will increase the ..
  56. Phase 2 Study of rAAV1-CB-hAAT for Treatment of Alpha-1 Antitrypsin Deficiency
    Jeffrey D Chulay; Fiscal Year: 2013
    ..The study is a non-randomized, open-label, multi-center, sequential, three-arm, Phase 2 clinical trial evaluating the safety and efficacy of administration of a rAAV1-CB-hAAT vector administered ..
  57. Somatosensory feedback controlling a neuroprosthesis
    Douglas J Weber; Fiscal Year: 2010
    ..Neural recordings will be made during limb movements imposed by a robot arm attached to the foot...
  58. Faith-Based Approaches to Treating Hypertension and Colon Cancer Prevention
    Hayley S Thompson; Fiscal Year: 2013
    ..Participants in the MINT lifestyle intervention arm will attend one face-to-face counseling followed by 8 sessions of telephone-based MINT sessions over the next 6 ..
  59. Mission Reconnect: Promoting Resilience and Reintegration of Post-Deployment Vete
    Janet Kahn; Fiscal Year: 2013
    ..In Phase II We will complete and evaluate the full program in a four-arm randomized controlled trial. Specific Aims: 1...
  60. Development of a nanosecond pulsed electric field system to treat skin cancer
    RICHARD LEE NUCCITELLI; Fiscal Year: 2011
    ..implementing safety features required by the ANSI/AAMI ES60601-1 and ES60601-2 standards, fabricating an adjustable arm to facilitate electrode placement on humans, developing a computer interface to record both patient and treatment ..
  61. Repurposing cholinesterase inhibitors for smoking cessation
    REBECCA ASHARE; Fiscal Year: 2013
    ..In this randomized, parallel-arm trial, I will compare the effects of galantamine with placebo on withdrawal-related cognitive deficits and short-..
  62. Development of an instrument to track oxygen from blood to mitochondria in vivo
    Kenneth A Schenkman; Fiscal Year: 2013
    ..Finally, in Aim 3, spectra will be acquired from the hands of healthy subjects during arm ischemia. These spectra will be used to calibrate in vivo LWR models...
  63. SEGMENTATION AND PATTERNING IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 2000
    ..The initial phase of the proposal is a structure function analysis of the arm protein. Most alleles of arm previously identified were selected based on its segment polarity phenotype...
  64. Prevention of Overfeeding During Infancy
    Kathryn G Dewey; Fiscal Year: 2010
    ..The second objective is to evaluate the relationship between parental feeding styles and infant intake. In one arm of the study, formula-fed infants will be randomly assigned to use the novel nipple or a conventional nipple...
  65. One Dimensional Hand Held Gamma Ray Scanner
    FARHAD DAGHIGHIAN; Fiscal Year: 2009
    ..That is why x-ray C- arm, and ultrasound are being used in many surgeries...
  66. Rapid release paclitaxel nanoparticles for bladder cancer intravestical therapy
    Ze Lu; Fiscal Year: 2009
    ..method to enhance the delivery of MMC to superficial bladder tumors, and tested this method in a randomized, two-arm NCI-supported international phase III trial in 14 academic centers...
  67. Minimum Y gene complement necessary for successful ART
    MONIKA WARD; Fiscal Year: 2009
    ..focus on analyzing various mouse models with limited Y gene complements: (1) males with an almost intact Y short arm but complete absence of Y long arm genes;(2) males with no Y long arm genes and the known Y short arm genes limited ..
  68. The Role of the Cortex in Discoordination After Stroke
    Julius Dewald; Fiscal Year: 2009
    ..loss of certain muscle coactivation patterns and associated abnormal shoulder/elbow torque coupling in the paretic arm of individuals with hemiparetic stroke...
  69. Arm Motor Rehabilitation, Entertainment and Cognition System for the Elderly
    Grigore C Burdea; Fiscal Year: 2010
    ..SPECIFIC AIMS The first aim is to develop the BC 100 system for improving arm/shoulder motion, motor control, endurance, grasp strength, memory, anticipation and reaction time in elderly ..
  70. Resistance in HIV-infected infants after extended ARV prophylaxis: PEPI-Malawi
    Susan H Eshleman; Fiscal Year: 2010
    ..most women received sdNVP in labor, and 3,352 infants were randomized to one of three study arms: (1) the control arm [sdNVP plus 1 week of daily ZDV], (2) the extended NVP arm [control regimen plus daily NVP to 14 weeks of age], or (..
  71. Sensor Network for Monitoring Real-world Arm Activity of Rehabilitation Patients
    Gitendra Uswatte; Fiscal Year: 2010
    ..The PI has shown that his group's measure is correlated with self-reported more-impaired arm use in daily life after brain injury, and is a reliable and valid index of rehabilitation outcome...
  72. VOCAL MEASURES OF STRESS-ANXIETY: NURSING APPLICATIONS
    Barbara Fuller; Fiscal Year: 1993
    ..Both foci have emerged from research in the previous years. One arm of the basic research is to begin an investigation into a radically new area of physiological or voice measurement ..
  73. THE BIOMECHANICS OF OCCUPATIONAL SHOULDER INJURIES
    Andrew Karduna; Fiscal Year: 2001
    ..Institute of Occupational Safety and Health (NIOSH) has identified a clear epidemiological link between repetitive arm motion and shoulder disorders in the workplace, there are few scientific data available regarding the biomechanics ..
  74. Implanted Neuroprosthesis for Restoring Arm and Hand Function after Stroke
    Jayme Knutson; Fiscal Year: 2009
    ..neuromuscular electrical stimulation (NMES) neuroprosthesis that enables stroke survivors to use their paretic arm and hand again to perform activities of daily living...
  75. NAPRTCS CLINICAL TRIALS IN PRIMARY & REPEAT TRANSPLANTS
    William Harmon; Fiscal Year: 2002
    ..recipients to test the 1st hypothesis, that patients randomized to RAD, cyclosporine (CSA) and prednisone (P) (test arm) will have significantly less acute rejections in the first six months than the control arm of mycophenolate ..
  76. MUSCLE ACTIVITY AT ONSET OF HUMAN THREE-JOINT MOVEMENT
    GAIL KOSHLAND; Fiscal Year: 1992
    ..investigator's abstract) The purpose of this study is to investigate neural strategies used to make point-to-point arm movements in a desired direction...