leg

Summary

Summary: The inferior part of the lower extremity between the KNEE and the ANKLE.

Top Publications

  1. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    J Vasc Surg 45:S5-67. 2007
  2. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  3. ncbi Grip strength, postural control, and functional leg power in a representative cohort of British men and women: associations with physical activity, health status, and socioeconomic conditions
    Diana Kuh
    MRC National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free and University College Medical School, 1 19 Torrington Place, London, United Kingdom, WC1E 6BT
    J Gerontol A Biol Sci Med Sci 60:224-31. 2005
  4. ncbi Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise
    H Pilegaard
    Copenhagen Muscle Research Centre, The August Krogh Institute, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 279:E806-14. 2000
  5. pmc Leg motion classification with artificial neural networks using wavelet-based features of gyroscope signals
    Birsel Ayrulu-Erdem
    Department of Electrical and Electronics Engineering, Bilkent University, Bilkent, 06800 Ankara, Turkey
    Sensors (Basel) 11:1721-43. 2011
  6. ncbi Control of foot trajectory in human locomotion: role of ground contact forces in simulated reduced gravity
    Y P Ivanenko
    Sezione di Fisiologia Umana, Istituto Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
    J Neurophysiol 87:3070-89. 2002
  7. pmc Leg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study
    G D Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 55:867-72. 2001
  8. ncbi Modification of soft tissue vibrations in the leg by muscular activity
    J M Wakeling
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Appl Physiol (1985) 90:412-20. 2001
  9. ncbi Locomotor-like movements evoked by leg muscle vibration in humans
    V S Gurfinkel
    Laboratory of Neurobiology of Motor Control, Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia
    Eur J Neurosci 10:1608-12. 1998
  10. ncbi A comparison of leg power and leg strength within the InCHIANTI study: which influences mobility more?
    Jonathan F Bean
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, and Hebrew Rehabilitation Center for the Aged, Boston, Massachusetts 02131, USA
    J Gerontol A Biol Sci Med Sci 58:728-33. 2003

Detail Information

Publications332 found, 100 shown here

  1. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    J Vasc Surg 45:S5-67. 2007
  2. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  3. ncbi Grip strength, postural control, and functional leg power in a representative cohort of British men and women: associations with physical activity, health status, and socioeconomic conditions
    Diana Kuh
    MRC National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free and University College Medical School, 1 19 Torrington Place, London, United Kingdom, WC1E 6BT
    J Gerontol A Biol Sci Med Sci 60:224-31. 2005
    ....
  4. ncbi Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise
    H Pilegaard
    Copenhagen Muscle Research Centre, The August Krogh Institute, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 279:E806-14. 2000
    ..On day 5, nuclei were isolated from biopsies of the vastus lateralis muscle of the untrained and the trained leg before exercise and from the trained leg immediately after exercise and after 15 min, 1 h, 2 h, and 4 h of recovery...
  5. pmc Leg motion classification with artificial neural networks using wavelet-based features of gyroscope signals
    Birsel Ayrulu-Erdem
    Department of Electrical and Electronics Engineering, Bilkent University, Bilkent, 06800 Ankara, Turkey
    Sensors (Basel) 11:1721-43. 2011
    ..DWT) decomposition and provide them as input to multi-layer feed-forward artificial neural networks (ANNs) for leg motion classification...
  6. ncbi Control of foot trajectory in human locomotion: role of ground contact forces in simulated reduced gravity
    Y P Ivanenko
    Sezione di Fisiologia Umana, Istituto Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
    J Neurophysiol 87:3070-89. 2002
    ..The results did not depend on the specific instruction given to the subject. Therefore we conclude that minimal contact forces are sufficient for accurate foot trajectory control...
  7. pmc Leg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study
    G D Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 55:867-72. 2001
    ..The mechanism for this association is not well understood, however, and this was investigated by examining components of stature, cardiovascular disease risk factors and subsequent coronary heart disease in a prospective study...
  8. ncbi Modification of soft tissue vibrations in the leg by muscular activity
    J M Wakeling
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Appl Physiol (1985) 90:412-20. 2001
    ..and damping of free vibrations in these tissues were measured while isometric and isotonic contractions of the leg were performed...
  9. ncbi Locomotor-like movements evoked by leg muscle vibration in humans
    V S Gurfinkel
    Laboratory of Neurobiology of Motor Control, Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia
    Eur J Neurosci 10:1608-12. 1998
    ..It was found that continuous leg muscle vibration produced rhythmic locomotor-like stepping movements of the suspended leg, persisting up to the end ..
  10. ncbi A comparison of leg power and leg strength within the InCHIANTI study: which influences mobility more?
    Jonathan F Bean
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, and Hebrew Rehabilitation Center for the Aged, Boston, Massachusetts 02131, USA
    J Gerontol A Biol Sci Med Sci 58:728-33. 2003
    ..There was also evidence that the power-function relationship may be described as curvilinear. However, these findings have never been confirmed in a representative population...
  11. ncbi Cronobacter condimenti sp. nov., isolated from spiced meat, and Cronobacter universalis sp. nov., a species designation for Cronobacter sp. genomospecies 1, recovered from a leg infection, water and food ingredients
    Susan Joseph
    School of Science and Technology, Nottingham Trent University, Nottingham, UK
    Int J Syst Evol Microbiol 62:1277-83. 2012
    ..two previously assigned to Cronobacter genomospecies 1 (strains NCTC 9529(T) and 731, isolated from water and a leg infection, respectively) and two previously assigned to Cronobacter turicensis (strains 96 and 1435, isolated from ..
  12. ncbi Explosive power and asymmetry in leg muscle function in frequent fallers and non-fallers aged over 65
    Dawn A Skelton
    Cellular and Integrative Biology, Division of Biomedical Sciences, Imperial College School of Medicine, London SW7 2AZ, UK
    Age Ageing 31:119-25. 2002
    ..although low strength is a risk factor for falls, lower limb explosive power is more predictive of functional difficulties than strength. Power may be more predictive of a future fall than strength per se...
  13. ncbi Relative contributions of balance and voluntary leg-coordination deficits to cerebellar gait ataxia
    Susanne M Morton
    Interdisciplinary Program in Movement Science, Program in Physical Therapy, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurophysiol 89:1844-56. 2003
    ..We wanted to determine the relative contributions of balance versus leg-coordination deficits to cerebellar gait ataxia in humans...
  14. pmc Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle
    J T Treebak
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 52:891-900. 2009
    ..We hypothesised that signalling through TBC1D4 is involved in this effect of exercise as it is a common signalling element for insulin and exercise...
  15. pmc Patient-cooperative control increases active participation of individuals with SCI during robot-aided gait training
    Alexander Duschau-Wicke
    Sensory Motor Systems Lab, Institute of Robotics and Intelligent Systems, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland
    J Neuroeng Rehabil 7:43. 2010
    ..In this study, we have investigated the immediate effects of patient-cooperative versus non-cooperative robot-aided gait training on individuals with incomplete spinal cord injury (iSCI)...
  16. ncbi The prevalence of chronic chest and leg pain following cardiac surgery: a historical cohort study
    J Bruce
    Department of Public Health, University of Aberdeen, Polwarth Building, Medical School, Foresterhill, Aberdeen, AB25 2ZD, UK
    Pain 104:265-73. 2003
    ..Chronic pain following median sternotomy and saphenous vein harvesting is more common than hitherto reported and that patients undergoing CABG should be warned of this possibility...
  17. ncbi Effect of caffeine on perceptions of leg muscle pain during moderate intensity cycling exercise
    Robert W Motl
    University of Georgia, Department of Exercise Science, University of Georgia, Athens, GA 30602 6554, USA
    J Pain 4:316-21. 2003
    ..within-subjects experiment examined the effect of ingesting a large dose of caffeine on perceptions of leg muscle pain during moderate intensity cycling exercise...
  18. ncbi Effects of static stretching for 30 seconds and dynamic stretching on leg extension power
    Taichi Yamaguchi
    Laboratory of Human Performance and Fitness, Graduate School of Education, Hokkaido University, Sapporo, Japan
    J Strength Cond Res 19:677-83. 2005
    The purposes of this study were to clarify the effects of static stretching for 30 seconds and dynamic stretching on leg extension power. Eleven healthy male students took part in this study...
  19. ncbi Is leg length a biomarker of childhood conditions in older Chinese women? The Guangzhou Biobank Cohort Study
    C M Schooling
    Department of Community Medicine, School of Public Health, The University of Hong Kong, Hong Kong SAR, China
    J Epidemiol Community Health 62:160-6. 2008
    ..It was hypothesised that in transitioning populations better childhood conditions may bring forward puberty and thus decrease leg length, counteracting the overall positive effect of a favourable childhood environment on leg growth.
  20. ncbi Robot-assisted modifications of gait in healthy individuals
    Seok Hun Kim
    School of Physical Therapy and Rehabilitation Sciences, University of South Florida, Tampa, FL 33612, USA
    Exp Brain Res 202:809-24. 2010
    ..The results emphasize the short-term plasticity of locomotor circuits and provide a possible basis for persons learning to achieve more functional gait patterns following a stroke or other neurological disorders...
  21. ncbi On the origin of planar covariation of elevation angles during human locomotion
    Y P Ivanenko
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 306 via Ardeatina, 00179 Rome, Italy
    J Neurophysiol 99:1890-8. 2008
    b>Leg segment rotations in human walking covary, so that the three-dimensional trajectory of temporal changes in the elevation angles lies close to a plane...
  22. ncbi Runners adjust leg stiffness for their first step on a new running surface
    D P Ferris
    Department of Integrative Biology, University of California, Berkeley 94720 3140, USA
    J Biomech 32:787-94. 1999
    Human runners adjust the stiffness of their stance leg to accommodate surface stiffness during steady state running. This adjustment allows runners to maintain similar center of mass movement (e.g...
  23. ncbi A comparison of drop jump training methods: effects on leg extensor strength qualities and jumping performance
    W B Young
    School of Human Movement and Sport Sciences, University of Ballarat, Victoria, Australia
    Int J Sports Med 20:295-303. 1999
    ..of this study was to determine the effects of two drop jump (DJ) training methods on the strength qualities of the leg extensors and vertical jumping performance...
  24. pmc Measurement of body fat using leg to leg bioimpedance
    R Y Sung
    Department of Paediatrics, The Chinese University of Hong Kong, 6 F Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong
    Arch Dis Child 85:263-7. 2001
    1) To validate a leg to leg bioimpedance analysis (BIA) device in the measurement of body composition in children by assessment of its agreement with dual energy x ray absorptiometry (DXA) and its repeatability...
  25. ncbi Childhood socioeconomic circumstances and adult height and leg length in central and eastern Europe
    E Webb
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    J Epidemiol Community Health 62:351-7. 2008
    Adult height and leg length have been shown to be positively associated with childhood socioeconomic circumstances in several studies in western populations...
  26. pmc Trends in lower-extremity amputations in people with and without diabetes in Spain, 2001-2008
    Ana López-de-Andrés
    Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Rey Juan Carlos University, Madrid, Spain
    Diabetes Care 34:1570-6. 2011
    ..To examine trends in nontraumatic lower-extremity amputations (LEAs) over an 8-year period in patients with and without diabetes in Spain...
  27. ncbi Identifying neuropathic back and leg pain: a cross-sectional study
    Iain D Beith
    School of Rehabilitation Sciences, Faculty of Health and Social Care Sciences, St George s University of London Kingston University, Cranmer Terrace, London SW17 0RE, UK
    Pain 152:1511-6. 2011
    ..pain screening questionnaire to identify likely pain mechanisms in 343 patients with low back pain with or without leg pain in southeastern England referred for physiotherapy...
  28. ncbi Blood oxygenation level-dependent magnetic resonance imaging of the skeletal muscle in patients with peripheral arterial occlusive disease
    Hans Peter Ledermann
    Department of Radiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Circulation 113:2929-35. 2006
    ..We compared the calf muscle BOLD response of patients with peripheral arterial occlusive disease (PAOD) to that of an age-matched non-PAOD group during postischemic reactive hyperemia...
  29. pmc Enhancement of pinch force in the lower leg by anodal transcranial direct current stimulation
    Satoshi Tanaka
    ERATO Shimojo Implicit Brain Function Project, Japan Science and Technology Agency, Atsugi, Kanagawa, 243 0198, Japan
    Exp Brain Res 196:459-65. 2009
    ..Here, we investigated whether tDCS could also improve leg motor functions...
  30. ncbi Adjusting step count recommendations for anthropometric variations in leg length
    Michael W Beets
    Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
    J Sci Med Sport 13:509-12. 2010
    ..This estimate overlooks the impact of anthropometric differences between individuals, notably leg length, which is related to step frequency...
  31. ncbi Strategies for dynamic stability during locomotion on a slippery surface: effects of prior experience and knowledge
    Daniel S Marigold
    Gait and Posture Lab, Department of Kinesiology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    J Neurophysiol 88:339-53. 2002
    ..In conclusion, prior experience with the perturbations allows subsequent modification and knowledge of the surface condition results in proactive adjustments to safely traverse the slippery surface...
  32. ncbi Transcranial magnetic stimulation during resistance training of the tibialis anterior muscle
    L Griffin
    Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX, USA
    J Electromyogr Kinesiol 17:446-52. 2007
    ..These data indicate that there may be an increase in cortical excitability during the first few weeks of resistance training of the TA muscle...
  33. ncbi Validity of leg-to-leg bioelectrical impedance measurement in males
    A Cable
    Department of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    J Sports Med Phys Fitness 41:411-4. 2001
    BACKGROUND: This study determined the validity of the leg-to-leg bioelectrical impedance analysis (BIA) system (Tanita Body Fat Analyzer, TBF 105, Tanita Corporation of America, Inc...
  34. ncbi Fluid responsiveness predicted by noninvasive bioreactance-based passive leg raise test
    Brahim Benomar
    Departement d Anesthesie Reanimation, GH Pitié Salpétrière, Assistance Publique Hopitaux de Paris AP HP, UMPC Université Paris 06, 75013, Paris, France
    Intensive Care Med 36:1875-81. 2010
    To study the feasibility of predicting fluid responsiveness (FR) by passive leg raising (PLR) using a Bioreactance-based noninvasive cardiac output monitoring device (NICOM).
  35. ncbi Greater cross education following training with muscle lengthening than shortening
    T Hortobagyi
    Biomechanics Laboratory, East Carolina University, Greenville, NC 27858, USA
    Med Sci Sports Exerc 29:107-12. 1997
    ....
  36. ncbi Serial 2-point ultrasonography plus D-dimer vs whole-leg color-coded Doppler ultrasonography for diagnosing suspected symptomatic deep vein thrombosis: a randomized controlled trial
    Enrico Bernardi
    Department of Emergency and Accident Medicine, Civic Hospital, Conegliano, Italy
    JAMA 300:1653-9. 2008
    ..with ultrasonography either by the proximal veins (2-point ultrasonography) or the entire deep vein system (whole-leg ultrasonography)...
  37. pmc Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects
    F A Dinenno
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 531:573-9. 2001
    ..In Study 1, we determined whether age-associated reductions in basal whole-leg (femoral artery) blood flow and vascular conductance are modulated by habitual physical activity by studying 89 ..
  38. ncbi Diagnostic accuracy of passive leg raising for prediction of fluid responsiveness in adults: systematic review and meta-analysis of clinical studies
    Fabio Cavallaro
    Department of Anesthesiology and Intensive Care, Intensive Care Unit, Catholic University School of Medicine, Agostino Gemelli Hospital, Rome, Italy
    Intensive Care Med 36:1475-83. 2010
    To systematically review the published evidence on the ability of passive leg raising-induced changes in cardiac output (PLR-cCO) and in arterial pulse pressure (PLR-cPP) to predict fluid responsiveness.
  39. ncbi Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy
    J Peripher Nerv Syst 15:202-7. 2010
    ..performed a multicenter study to assess the normative values of intraepidermal nerve fiber (IENF) density at distal leg stratified by age deciles. Eight skin biopsy laboratories from Europe, USA, and Asia submitted eligible data...
  40. pmc Associations of height, leg length, and lung function with cardiovascular risk factors in the Midspan Family Study
    D Gunnell
    Department of Social Medicine, University of Bristol, Bristol, UK
    J Epidemiol Community Health 57:141-6. 2003
    ..Some studies have shown that leg length, an indicator of pre-pubertal nutritional status, is the component of height most strongly associated with ..
  41. ncbi Viewing the motion of human body parts activates different regions of premotor, temporal, and parietal cortex
    Kylie J Wheaton
    Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia
    Neuroimage 22:277-88. 2004
    ..During a 3T fMRI study, 12 healthy subjects viewed human face, hand, and leg motion, which was not directed at or did not involve an object...
  42. ncbi Effect of duration of upper- and lower-extremity rehabilitation sessions and walking speed on recovery of interlimb coordination in hemiplegic gait
    Gert Kwakkel
    Department of Physical Therapy and Research Institute for Fundamental and Clinical Human Movement Sciences, University Hospital Vrije Universiteit, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Phys Ther 82:432-48. 2002
    ..The effects of different durations of rehabilitation sessions for the upper extremities (UEs) and lower extremities (LEs) on the recovery of interlimb coordination in hemiplegic gait in patients who have had a stroke were investigated...
  43. ncbi Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia
    Satoaki Matoba
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am Heart J 156:1010-8. 2008
    ....
  44. ncbi Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia
    Masahiro Kajiguchi
    Department of Cardiology, Nagoya University Graduate School of Medicine, Japan
    Circ J 71:196-201. 2007
    ..However, because one-third of treated patients fail to respond, the present study was an exploration of the characteristics of responders and non-responders to this treatment regimen...
  45. pmc A strategy for identifying locomotion modes using surface electromyography
    He Huang
    Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, RI 02881, USA
    IEEE Trans Biomed Eng 56:65-73. 2009
    ..Due to the nonstationary characteristics of leg EMG signals during locomotion, a new phase-dependent EMG PR strategy was proposed for classifying the user's ..
  46. ncbi Sex-specific differences in leg fat uptake are revealed with a high-fat meal
    Susanne B Votruba
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 291:E1115-23. 2006
    ..efficiency of meal fat uptake into upper body subcutaneous fat was similar in both sexes, but women had a greater leg fat uptake, especially in response to a HF meal (P < 0.0001)...
  47. ncbi Short-term natural history of isolated gastrocnemius and soleal vein thrombosis
    P S Macdonald
    Department of Surgery, McGill University, Montreal, Quebec, Canada
    J Vasc Surg 37:523-7. 2003
    ..The purpose of this study was to establish the incidence rate of propagation of isolated gastrocnemius and soleal vein thrombosis (IGSVT) into the deep veins of the calf and thigh...
  48. ncbi ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Sur
    Alan T Hirsch
    Circulation 113:e463-654. 2006
  49. ncbi In vivo high-resolution conductivity imaging of the human leg using MREIT: the first human experiment
    Hyung Joong Kim
    Department of Biomedical Engineering, Kyung Hee University, Yongin, Gyeonggi 446 701, Korea
    IEEE Trans Med Imaging 28:1681-7. 2009
    We present the first in vivo cross-sectional conductivity image of the human leg with 1.7 mm pixel size using the magnetic resonance electrical impedance tomography (MREIT) technique...
  50. ncbi Leg muscle recruitment in highly trained cyclists
    Andrew R Chapman
    Division of Physiotherapy, The University of Queensland, Brisbane, QLD, Australia
    J Sports Sci 24:115-24. 2006
    In this study, we examined patterns of leg muscle recruitment and co-activation, and the relationship between muscle recruitment and cadence, in highly trained cyclists...
  51. ncbi Muscle interstitial ATP and norepinephrine concentrations in the human leg during exercise and ATP infusion
    Stefan P Mortensen
    The Copenhagen Muscle Research Centre, Rigshospitalet, Denmark, Denmark
    J Appl Physiol (1985) 107:1757-62. 2009
    ..Here we evaluated the effects of arterial ATP infusion and exercise on leg muscle interstitial ATP and norepinephrine (NE) concentrations to gain insight into the interstitial and ..
  52. ncbi Variation in neuromuscular responses during acute whole-body vibration exercise
    Andrew F J Abercromby
    Wyle Laboratories, Inc, Houston, TX 77058, USA
    Med Sci Sports Exerc 39:1642-50. 2007
    b>Leg muscle strength and power are increased after whole-body vibration (WBV) exercise...
  53. ncbi Ambulatory activity, body composition, and lower-limb muscle strength in older adults
    David Scott
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Med Sci Sports Exerc 41:383-9. 2009
    ..unclear how the amount of ambulatory activity (AA) participated in by older adults relates to body composition or leg strength...
  54. pmc Contribution of skeletal muscle 'ergoreceptors' in the human leg to respiratory control in chronic heart failure
    A C Scott
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    J Physiol 529:863-70. 2000
    ..We have aimed to clarify the contribution of muscle metaboreceptors in the leg to ventilation and to compare this with the contribution of mechanoreceptors...
  55. ncbi Versatility of the pedicled peroneal artery perforator flaps for soft-tissue coverage of the lower leg and foot defects
    Ting Chen Lu
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, 5, Fu Hsing St Kuei Shan, Taoyuan, Taiwan
    J Plast Reconstr Aesthet Surg 64:386-93. 2011
    Even a small defect in the lower leg and foot with exposure of bones or tendons can result in an intractable wound, which may require a microsurgical tissue transfer...
  56. pmc Impaired leg vasodilatory function after stroke: adaptations with treadmill exercise training
    Frederick M Ivey
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201 1524, USA
    Stroke 41:2913-7. 2010
    Resting and reactive hyperemic leg blood flows are significantly reduced in the paretic compared with the nonparetic limb after disabling stroke...
  57. ncbi Effects of low-frequency whole-body vibration on motor-evoked potentials in healthy men
    Katya N Mileva
    Sport and Exercise Science Research Centre, Faculty of Engineering, Science and the Built Environment, London South Bank University, 103 Borough Road, London SE1 0AA, UK
    Exp Physiol 94:103-16. 2009
    ..Motor-evoked potentials (MEPs) elicited in response to transcranial magnetic stimulation (TMS) of the leg area of the motor cortex were recorded in TA and soleus (SOL) muscles of seven healthy male subjects whilst ..
  58. ncbi Compensatory mechanisms in below-knee amputee gait in response to increasing steady-state walking speeds
    Anne K Silverman
    Department of Mechanical Engineering, The University of Texas, 1 University Station, Austin, TX 78712, USA
    Gait Posture 28:602-9. 2008
    ..We hypothesized that amputees would rely more on their intact leg to generate greater propulsion relative to the residual leg, which would result in greater GRF asymmetry between ..
  59. ncbi Are height and leg length universal markers of childhood conditions? The Guangzhou Biobank cohort study
    C M Schooling
    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    J Epidemiol Community Health 62:607-14. 2008
    ..In the first generations to experience the epidemiologic transition and associated economic development, epigenetic constraints on growth might preclude improved childhood conditions from increasing leg growth or height.
  60. ncbi Review of secondary physical conditions associated with lower-limb amputation and long-term prosthesis use
    Robert Gailey
    Department of Physical Therapy, University of Miami Leonard M Miller School of Medicine, Coral Gables, FL, USA
    J Rehabil Res Dev 45:15-29. 2008
    ..limb loss commonly complain of back pain, which is linked to poor prosthetic fit and alignment, postural changes, leg-length discrepancy, amputation level, and general deconditioning...
  61. ncbi The effect of backpack heaviness on trunk-lower extremity muscle activities and trunk posture
    Yusuf S S M Al-Khabbaz
    Department of Physical Therapy, Faculty of Health Science, Kobe University, 7 10 2 Tomogaoka, Suma ku, Kobe 654 0142, Japan
    Gait Posture 28:297-302. 2008
    ..However, it is recommended to study other backpack factors such as frequency of usage, usage time, type of the backpack and age to come up with a complete usage recommendation...
  62. ncbi Regional fat mass by DXA: high leg fat mass attenuates the relative risk of insulin resistance and dyslipidaemia in obese but not in overweight postmenopausal women
    G Aasen
    Spesialistsenteret Pilestredet Park, Oslo, Norway
    Scand J Clin Lab Invest 68:204-11. 2008
    ..b>Leg FM may attenuate the increased risk of cardiovascular disease and diabetes imposed by increased trunk FM in normal ..
  63. ncbi Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease
    Berthold Amann
    Department of Medicine, Franziskuskrankenhaus, Berlin Vascular Center, Berlin, Germany
    Cell Transplant 18:371-80. 2009
    ..due to severe critical limb ischemia had autologous bone marrow cells (BMC) transplanted into the ischemic leg. Patients 1-12 received Ficoll-isolated bone marrow mononuclear cells (total cell number 1.1 +/- 1...
  64. ncbi Stability limits, single-leg jump, and body awareness in older Tai Chi practitioners
    Amanda L Gyllensten
    Section of Physiotherapy, Department of Health Sciences, Lund University, Lund, Sweden
    Arch Phys Med Rehabil 91:215-20. 2010
    ..Cross-sectional study...
  65. ncbi Interaction of leg stiffness and surfaces stiffness during human hopping
    D P Ferris
    Department of Human Biodynamics, University of California, Berkeley 94720 4480, USA
    J Appl Physiol (1985) 82:15-22; discussion 13-4. 1997
    When mammals run, the overall musculoskeletal system behaves as a single linear "leg spring"...
  66. ncbi Clinical outcomes among low back pain consulters with referred leg pain in primary care
    Jonathan C Hill
    Arthritis Research UK National Primary Care Centre, Keele University, Keele, Staffordshire, United Kingdom
    Spine (Phila Pa 1976) 36:2168-75. 2011
    ..Merged data from two primary care prospective cohort studies...
  67. pmc Socioeconomic inequalities in height, leg length and trunk length among children aged 6.5 years and their parents from the Republic of Belarus: evidence from the Promotion of Breastfeeding Intervention Trial (PROBIT)
    Rita Patel
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Ann Hum Biol 38:592-602. 2011
    Lower socioeconomic position is associated with shorter stature, in particular shorter leg length, but the magnitude of these associations in non-Western countries has received little attention.
  68. ncbi Validity of leg-to-leg bioelectrical impedance measurement in highly active women
    Selma Civar
    Akdeniz University School of Physical Education and Sports, Department of Coaching Education, Sports Sciences Research and Application Center, Kampus, Antalya, Turkey
    J Strength Cond Res 20:359-65. 2006
    The aim of this study was to compare the validity of the leg-to-leg bioelectrical impedance analysis (BIA) method with that of anthropometry using hydrostatic weighing (HW) as the criterion test...
  69. pmc Similar muscles contribute to horizontal and vertical acceleration of center of mass in forward and backward walking: implications for neural control
    Karen Jansen
    Research Center for Movement Control and Neuroplasticity, Department of Biomedical Kinesiology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Neurophysiol 107:3385-96. 2012
    b>Leg kinematics during backward walking (BW) are very similar to the time-reversed kinematics during forward walking (FW). This suggests that the underlying muscle activation pattern could originate from a simple time reversal, as well...
  70. ncbi Measurement properties of a hand-held inclinometer during straight leg raise neurodynamic testing
    Benjamin S Boyd
    Samuel Merritt University, Department of Physical Therapy, 450 30th Street, Oakland, CA 94609, USA
    Physiotherapy 98:174-9. 2012
    The most common lower quarter neurodynamic test is the straight leg raise (SLR) test. Quantification of limb motion during SLR testing should utilize reliable and valid measurement tools that are highly sensitive to change...
  71. ncbi Only fat infiltrated muscles in resting lower leg of FSHD patients show disturbed energy metabolism
    H E Kan
    Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    NMR Biomed 23:563-8. 2010
    ..Normal appearing muscles on T1 weighted images of patients showed normal phosphoryl metabolism, which suggests that in FSHD disease progression is truly muscle specific...
  72. ncbi Hip-muscle activation during the lunge, single-leg squat, and step-up-and-over exercises
    Samantha N Boudreau
    Div of Athletic Training, University of Kentucky, Lexington, KY, USA
    J Sport Rehabil 18:91-103. 2009
    ..Functional exercises are often used in strengthening programs after lower extremity injury. Activation levels of the stabilizing hip muscles have not been documented...
  73. pmc Differences in lower-extremity muscular activation during walking between healthy older and young adults
    Anne Schmitz
    Department of Biomedical Engineering, University of Wisconsin Madison, 3039 Mechanical Engineering Building, 1513 University Ave, Madison, WI 53706, USA
    J Electromyogr Kinesiol 19:1085-91. 2009
    ..We conclude that age-related changes in neuromuscular activity reflect a strategy of stiffening the limb during single support and likely contribute to reduced push off power at fast walking speeds...
  74. ncbi The efficacy of a new stimulation technology to increase venous flow and prevent venous stasis
    M Griffin
    The Vascular Noninvasive Screening and Diagnostic Centre, 30 Weymouth Street, London W1G 7BS, UK
    Eur J Vasc Endovasc Surg 40:766-71. 2010
    ..The aim was to determine: (a) dependence of venous blood velocity and ejected volume on the rates of stimulated calf contractions: (b) clinical factors affecting efficacy in healthy individuals...
  75. ncbi Increases in thigh muscle volume and strength by walk training with leg blood flow reduction in older participants
    Hayao Ozaki
    Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba, Japan
    J Gerontol A Biol Sci Med Sci 66:257-63. 2011
    We examined the effects of walk training combined with leg blood flow reduction (BFR) on muscle hypertrophy as well as on peak oxygen uptake (VO₂ peak) in older individuals...
  76. ncbi Therapy of isolated calf muscle vein thrombosis: a randomized, controlled study
    Thomas Schwarz
    Department of Vascular Medicine, Herz Zentrum, Bad Krozingen, Germany
    J Vasc Surg 52:1246-50. 2010
    ..There are no data from prospective, controlled studies. Objective of this article was to compare the efficacy and safety of a short-term course of anticoagulation with compression therapy alone...
  77. ncbi Sensor-driven four-channel stimulation of paretic leg: functional electrical walking therapy
    Jovana Kojović
    SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D3, 9220 Aalborg, Denmark
    J Neurosci Methods 181:100-5. 2009
    ..05). The statistical strength of the clinical study was low (<70%), suggesting the need for a larger, randomized clinical trial...
  78. ncbi The influence of leg-to-body ratio (LBR) on judgments of female physical attractiveness: assessments of computer-generated images varying in LBR
    David A Frederick
    Department of Psychology, University of California, Los Angeles, California, USA
    Body Image 7:51-5. 2010
    The leg-to-body ratio (LBR), which is reliably associated with developmental stability and health outcomes, is an understudied component of human physical attractiveness...
  79. pmc Lower leg muscle involvement in Duchenne muscular dystrophy: an MR imaging and spectroscopy study
    Martin Torriani
    Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Skeletal Radiol 41:437-45. 2012
    To describe the involvement of lower leg muscles in boys with Duchenne muscular dystrophy (DMD) by using MR imaging (MRI) and spectroscopy (MRS) correlated to indices of functional status.
  80. pmc Multiclass real-time intent recognition of a powered lower limb prosthesis
    Huseyin Atakan Varol
    Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Biomed Eng 57:542-51. 2010
    ..recognizing patterns in prosthesis sensor data in real time, without the need for instrumentation of the sound-side leg. Specifically, the intent recognizer utilizes time-based features extracted from frames of prosthesis signals, ..
  81. ncbi The relationship between leg power and physical performance in mobility-limited older people
    Jonathan F Bean
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
    J Am Geriatr Soc 50:461-7. 2002
    The purpose of this study was to assess the influence of leg power and leg strength on the physical performance of community-dwelling mobility-limited older people.
  82. ncbi Muscle activity during the active straight leg raise (ASLR), and the effects of a pelvic belt on the ASLR and on treadmill walking
    Hai Hu
    Research Institute MOVE, Faculty of Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
    J Biomech 43:532-9. 2010
    ..pregnancy-related pelvic girdle pain (PPP), or athletes with groin pain, may have trouble with the active straight leg raise (ASLR), for which a pelvic belt can be beneficial...
  83. ncbi Approach to leg edema of unclear etiology
    John W Ely
    Department of Family Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Am Board Fam Med 19:148-60. 2006
    A common challenge for primary care physicians is to determine the cause and find an effective treatment for leg edema of unclear etiology...
  84. ncbi On the relative contribution of the paretic leg to the control of posture after stroke
    Melvyn Roerdink
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University, Amsterdam
    Neurorehabil Neural Repair 23:267-74. 2009
    ..Reduced postural steadiness and asymmetry of weight bearing are characteristic for posture after stroke...
  85. ncbi Anticipatory postural adjustments associated with a forward leg raising in children: effects of age, segmental acceleration and sensory context
    Estelle Palluel
    Laboratoire TIMC IMAG, Equipe Sante, Plasticite, Motricite, UMR 5525, Universite Joseph Fourier CNRS, Grenoble, 38 706 La Tronche Cedex, France
    Clin Neurophysiol 119:2546-54. 2008
    The purpose of this study was to determine the influence of age, segmental acceleration and sensory context on anticipatory postural adjustments (APAs) in a forward leg raising task.
  86. pmc Descending spinal cord volleys evoked by transcranial magnetic and electrical stimulation of the motor cortex leg area in conscious humans
    V Di Lazzaro
    Institute of Neurology, Catholic University, L go A Gemelli 8, 00168 Rome, Italy
    J Physiol 537:1047-58. 2001
    1. Descending corticospinal volleys evoked after transcranial magnetic or electrical stimulation of the leg area of the motor cortex were recorded from an electrode in the spinal epidural space of six conscious patients who had ..
  87. ncbi Cerebellar responses evoked by nociceptive leg withdrawal reflex as revealed by event-related FMRI
    A Dimitrova
    Department of Neurology, University of Essen, 45122 Essen, Germany
    J Neurophysiol 90:1877-86. 2003
    The aim of the present study was to examine nociceptive leg withdrawal reflex-related areas in the human cerebellum using event-related functional brain imaging (fMRI)...
  88. ncbi Complications associated with the use of urokinase and recombinant tissue plasminogen activator for catheter-directed peripheral arterial and venous thrombolysis
    K Ouriel
    Department of Vascular Surgery, The Cleveland Clinic Foundation, OH 44195, USA
    J Vasc Interv Radiol 11:295-8. 2000
    ....
  89. ncbi Association of plasma N-terminal pro-B-type natriuretic peptide with postoperative cardiac events in patients undergoing surgery for abdominal aortic aneurysm or leg bypass
    Harm H H Feringa
    Department of Vascular Surgery, Erasmus Medical College, University Medical Center, Rotterdam, The Netherlands
    Am J Cardiol 98:111-5. 2006
    ..Further studies in a larger number of patients are required to confirm these findings...
  90. ncbi Management of vasovagal syncope: controlling or aborting faints by leg crossing and muscle tensing
    C T Paul Krediet
    Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 106:1684-9. 2002
    ..A simple maneuver to prevent or diminish vasovagal reactions would be beneficial...
  91. ncbi Validity of the active straight leg raise test for measuring disease severity in patients with posterior pelvic pain after pregnancy
    Jan M A Mens
    Spine and Joint Centre, Rotterdam, The Netherlands
    Spine (Phila Pa 1976) 27:196-200. 2002
    A cross-sectional analysis was performed with a group of women meeting strict criteria for posterior pelvic pain after pregnancy. The active straight leg raise test and common severity measurement scales of lumbopelvic pain were scored.
  92. ncbi Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, Aging, and Body Composition Study--Dual-Energy X-ray Absorptiometry and Body Composition Working Group
    M Visser
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Appl Physiol (1985) 87:1513-20. 1999
    ..the accuracy of fan-beam dual-energy X-ray absorptiometry (DEXA) for measuring total body fat-free mass (FFM) and leg muscle mass (MM) in elderly persons...
  93. ncbi Classification of low back-related leg pain--a proposed patho-mechanism-based approach
    Axel Schäfer
    Rückenzentrum am Michel, Hamburg, Germany
    Man Ther 14:222-30. 2009
    b>Leg pain is a frequent accompaniment to low back pain, arising from disorders of neural or musculoskeletal structures of the lumbar spine...
  94. ncbi Adaptational responses in dynamic stability during disturbed walking in the elderly
    Stefanie Bierbaum
    Department of Training and Movement Sciences, Humboldt University Berlin, Germany
    J Biomech 43:2362-8. 2010
    ..the hard trial after the first unexpected perturbation, both age-groups increased MS at touchdown of the disturbed leg compared to baseline, reflecting fast predictive adjustments...
  95. ncbi The effects of 12 weeks of resistance exercise training on disease severity and autonomic modulation at rest and after acute leg resistance exercise in women with fibromyalgia
    J Derek Kingsley
    Department of Physical Education, Indiana State University, Terre Haute, IN 47809, USA
    Arch Phys Med Rehabil 91:1551-7. 2010
    To determine the effects of 12 weeks of resistance exercise training (RET) on disease severity and autonomic modulation at rest and after acute leg resistance exercise in women with fibromyalgia (FM) and healthy controls (HCs).
  96. ncbi Did continuous femoral and sciatic nerve block obscure the diagnosis or delay the treatment of acute lower leg compartment syndrome? A case report
    M Anthony Cometa
    Department of Anesthesiology, Division of Acute Pain Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Pain Med 12:823-8. 2011
    ..We report a case of acute lower extremity compartment syndrome that was diagnosed despite continuous regional analgesia with 0.2% ropivacaine via femoral and sciatic nerve catheters...
  97. ncbi Acute peripheral blood flow response induced by passive leg cycle exercise in people with spinal cord injury
    Laurent Ballaz
    Physiology and Biomechanics Laboratory, Sports Department, Rennes 2 University, France
    Arch Phys Med Rehabil 88:471-6. 2007
    To determine the acute femoral artery hemodynamic response in paraplegic subjects during a passive leg cycle exercise.
  98. ncbi Pulse contour analysis to assess hemodynamic response to passive leg raising
    Bart Geerts
    Department of Anaesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiothorac Vasc Anesth 25:48-52. 2011
    The authors evaluated the ability of 2 pulse contour cardiac output (CO) techniques to track CO changes during passive leg raising (PLR) to assess fluid loading responsiveness.
  99. ncbi The effectiveness of intradialytic leg ergometry exercise for improving sedentary life style and fatigue among patients with chronic kidney disease: a randomized clinical trial
    Yuanmay Chang
    Department of Nursing, Shin Kong Memorial Hospital, Taipei, Taiwan
    Int J Nurs Stud 47:1383-8. 2010
    ..Over the past three decades, research has been carried out on the effects of exercise on chronic kidney disease patients for improving their physical potential...
  100. ncbi The active straight leg raising test (ASLR) in pregnant women: differences in muscle activity and force between patients and healthy subjects
    M de Groot
    Department of Biomedical Physics and Technology, University Medical Center Rotterdam, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Man Ther 13:68-74. 2008
    ..The objective was to determine muscle activation patterns of trunk and leg muscles during the active straight leg raising test (ASLR) and static hip flexion, and to determine maximal hip ..
  101. ncbi The passive leg-raising maneuver cannot accurately predict fluid responsiveness in patients with intra-abdominal hypertension
    Yazine Mahjoub
    Medical and Surgical Intensive Care Unit, Department of Anesthesia and Intensive Care, Amiens University Medical Center, Amiens, France
    Crit Care Med 38:1824-9. 2010
    The passive leg-raising maneuver is a reversible fluid-loading procedure used to predict fluid responsiveness in mechanically ventilated patients...

Research Grants75

  1. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..of testosterone to DHT is obligatory for mediating its effects on fat-free mass, muscle size, muscle strength, and leg power in men...
  2. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..extensor muscle group resulted in significant increase skeletal muscle cross-sectional area (CSA), reduction in % leg FM and a trend towards decrease in visceral adipose tissue (VAT) CSA...
  3. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..We observed increased hind leg lean mass in n-3 FA fed mice. However, 40% CR is associated with increased bone loss...
  4. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..and CMT patients suffer from degeneration of the peripheral nerves that control sensory information of the foot/leg and hand/arm. The nerve degeneration causes the subsequent degeneration of the muscles in the extremities...
  5. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..It is a significant public health burden and, at its worst, leads to leg amputations...
  6. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..The purpose of the proposed three-year pilot study is to determine whether lower extremity (leg) endothelial function, exercise functions, and skeletal muscle mitochondrial gene regulation are different among ..
  7. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..functional status, and quality of life (Specific Aim #3: life space mobility, Short Physical Performance Battery, leg and hand grip strength, Short Form-36 Health Related Quality of Life, Impact of Weight on Quality of Life-Lite)...
  8. Arm Exercise versus Other Stress Test Modalities for Clinical Outcome Prediction
    WADE HAMPTON MARTIN; Fiscal Year: 2013
    ..applicant): Treadmill exercise capacity and hemodynamic, symptomatic, and electrocardiographic (ECG) responses to leg exercise are powerful predictors of all-cause mortality and other important measures of health outcome but none of ..
  9. Characterizing Ankle Function During Sloped Locomotion For Prosthesis Development
    Alena Grabowski; Fiscal Year: 2012
    ..Thus, an ankle-foot prosthesis must be able to accomodate changes in velocity and slope to allow Veterans with a leg amputation to achieve full functional equivalence during locomotion...
  10. DNA Repair of Endogenous Lesions in Carcinogenesis
    Rabindra Roy; Fiscal Year: 2010
    ..In this project we will use the Long Evans Cinnamon (LEG) rat as a model to investigate the mechanism...
  11. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    ..CMT affects both motor and sensory nerves. A typical characteristic includes weakness of the foot and lower leg muscles, which may result in foot drop and a high-stepped gait with frequent tripping or falls...
  12. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012
    ..or boots reduce the need for muscular contractions across the ankle joint, leading to atrophy and weakness of the leg muscles...
  13. Dietary Nitrate to Augment Exercise Training Benefits in DM+PAD
    Jason David Allen; Fiscal Year: 2013
    ..DM+PAD patients are at increased risk for disease progression to critical leg ischemia, lower extremity amputation, and cardiovascular events...
  14. Histone Deacetylation Regulates Growth Plate Development
    Lei Wei; Fiscal Year: 2013
    ..Prevention of leg length discrepancy, dwarfism, and other disorders of bone growth might also be possible once molecular triggers and ..
  15. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
    ..for which we have no specific therapy, post-thrombotic syndrome, which causes debilitating swelling, pain and leg ulceration in 25-60% of DVT patients...
  16. Systemic Application for Injury Site Specific Delivery via Neutrophils to Treat B
    XUDONG J LI; Fiscal Year: 2013
    ..study will provide useful insights into a novel cost-effective therapeutic strategy for acute and chronic back/neck/leg pain involving systemic injection of non-protein, nano-structured, biocompatible fullerene conjugated with cFLFLF, ..
  17. Aging, Inflammation and Exercise in Chronic Stroke
    Alice S Ryan; Fiscal Year: 2012
    ..AMPK, JNK, IRS1- Ser307, Akt and p-38 MAPK phosphorylation) and GS activity in hemiparetic and nonparetic leg skeletal muscles...
  18. MECHANISMS OF ARTERIAL GRAFT HEALING
    Alexander W Clowes; Fiscal Year: 2013
    ..in Specific Aims 1 and 2 will be conducted in a longitudinal, prospective study of 150 patients undergoing leg bypass surgery, while the studies proposed in Specific Aim 3 will make use of DNA and de-identified, adjudicated ..
  19. Analysis of associations between anemia correction in CKD and mortality: CHOIR
    LYNDA ANNE MARIE SZCZECH; Fiscal Year: 2010
    ..and strength with a significant reduction in aching dizziness, anxiety, shortness of breath, muscle weakness, and leg cramps...
  20. Caring for Those Who Share: Mitigating Iron Deficiency in Regular Blood Donors
    Alan E Mast; Fiscal Year: 2013
    ..exercise tolerance, as well as neurological symptoms such as decreased cognitive function, pica and restless leg syndrome...
  21. The Johnston County OA Project: Arthritis and Disability
    Joanne M Jordan; Fiscal Year: 2013
    ..disease, and their interactive effects, upon OA outcomes, and extend the timeline for examination of risk (leg length inequality) and potentially protective factors (weight maintenance) upon these outcomes...
  22. Development of an instrument to track oxygen from blood to mitochondria in vivo
    Kenneth A Schenkman; Fiscal Year: 2013
    ..g., hand, arm, leg, and brain)...
  23. Prospective Study of Restless Leg Syndrome
    Xiang Gao; Fiscal Year: 2011
    ....
  24. FFA Production From Triglyceride-Rich Lipoproteins
    John M Miles; Fiscal Year: 2013
    ..Furthermore, in people with type 2 diabetes spillover correlated negatively with leg fat - that is, individuals with a large amount of leg fat ad lower spillover (an indication of more efficient fat ..
  25. Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in Females
    Dawn A Lowe; Fiscal Year: 2013
    ..Extensive functional analyses will include voluntary muscle performance, maximal in vivo lower-leg muscle strength, contractile capacity of isolated muscles, and molecular structure-function analyses of myosin...
  26. BEST-CLI Trial-CCC-Lead
    Kenneth Rosenfield; Fiscal Year: 2013
    ..HEALTH RELEVANCE: With the aging of the US population and increasing diabetes, there is an increase in ischemic leg pain and open leg ulcers, frequently requiring amputation...
  27. Genetic Epidemiology of Osteosarcoma
    Logan G Spector; Fiscal Year: 2010
    ..growth curve, the earlier peak in incidence in females, and the frequent occurrence of OS in the long bones of the leg suggest that the etiology of pediatric OS is linked to bone growth...
  28. Fibrotic effects and regulation of MMP proteins in thrombus resolution
    Rajabrata Sarkar; Fiscal Year: 2009
    ..Post-phlebitic syndrome can affect 25-75% of patients following DVT and includes leg swelling, pain, skin changes and ulceration of the skin...
  29. Tissue Oxygenation and Wound Healing
    Chandan K Sen; Fiscal Year: 2013
    ..We propose a prospective longitudinal study where adult non-diabetic patients with chronic leg ulcers visiting the OSU Comprehensive Wound Center will be enrolled.
  30. Role of Femoral Atherosclerosis in Functional Status, CVD Events, and Mortality
    CHRISTINA LYNN WASSEL; Fiscal Year: 2013
    ..Furthermore, intermittent claudication, critical leg ischemia, and amputation resulting from PAD adversely affect quality of life and functional status...
  31. Modulation of the Epithelial Sodium Channel by Proteases and Peptide Inhibitors
    CHRISTOPHER JOHN PASSERO; Fiscal Year: 2010
    ..in the transporter occur in some forms of high blood pressure and may be involved in a kidney disease that causes leg swelling...
  32. Muscle Afferent Feedback Effects in Patients with Heart Failure
    Markus Amann; Fiscal Year: 2013
    ..This unique, previously proven approach will enable us to evaluate the effects of group III/IV muscle afferents on leg blood flow, heart rate, blood pressure and ventilation during large and small muscle mass rhythmic exercise (..
  33. Aging, Sex, and Neural Cardiovascular Control During Dynamic Exercise
    Paul J Fadel; Fiscal Year: 2012
    ..accomplished by assessing carotid baroreflex function (variable pressure neck chamber) at rest and during dynamic leg exercise while directly measuring sympathetic nerve activity (microneurography), BP, and leg blood flow (Doppler ..
  34. Sex-specific movement differences in young adults with and without hip pain
    CARA L LEWIS; Fiscal Year: 2013
    ..movement patterns using kinematic data collected during movements including walking, stepping down, supine straight leg raise and prone hip extension on subjects with FAI and subjects without hip pain...
  35. BEST-CLI Trial-DCC
    Flora Sandra Siami; Fiscal Year: 2013
    ..HEALTH RELEVANCE: With the aging of the US population and increasing diabetes, there is an increase in ischemic leg pain and open leg ulcers, frequently requiring amputation...
  36. Variation in the Safety of Back Pain-Related Surgery
    Sohail K Mirza; Fiscal Year: 2010
    ..to know if clinical practice meets these standards;and if not, why not? Patients seeking relief for severe back and leg symptoms are vulnerable not only to misperceptions about efficacy of some types of back surgery, but they may also ..
  37. Concurrent Upper/Lower Extremity SCI Exercise with Stimulation
    LEE BARNETT; Fiscal Year: 2010
    ..limitation, we propose to augment a NuStep TRS4000, a recumbent cross trainer that provides a coupled reciprocal leg/arm extension exercise movement, with functional electrical stimulation (FES)...
  38. Paraspinal Denervation in Low Back Pain
    Andrew J Haig; Fiscal Year: 2010
    ..Electromyography (EMG) was shown to be a useful test. However the study did not look claudication (leg pain on walking), an extreme symptom of stenosis. Claudication can also occur in vascular disease...
  39. Ankle dorsiflexion splinting enhances endothelial function of aged leg muscles
    JUDY M DELP; Fiscal Year: 2013
    ..test the hypothesis that performance of daily ankle dorsiflexion splinting improves endothelial function and lower leg muscle blood flow in the elderly...
  40. Noninvasive Monitoring of In Situ Oxygenation and Cell Therapy in Infarct Heart
    Periannan Kuppusamy; Fiscal Year: 2010
    ..The myoblasts, derived from leg skeletal muscle tissue, can proliferate and differentiate into functional cells and thereby improve heart function...
  41. Mechanisms of Right Ventricular Dysfunction in PAH
    DAVID ALAN KASS; Fiscal Year: 2013
    ..RV function and PA interaction by invasive pressure-volume and right heart catheterization, using rate pacing and leg-exercise to assess reserve RV function;and 3) obtain RV biopsies to test the role of primary sarcomere dysfunction ..
  42. Retraining Spinal Circuits With Robot-Assisted Functional Electrical Stimulation
    Deborah Won; Fiscal Year: 2013
    ..Robotic assisted treadmill training is a separately developed therapy by which a motorized system powers leg orthoses to move a spinal cord injury (SCI) patient's legs in a trajectory designed to mimic walking while the ..
  43. Exploring Sarcoma Metastatic Potential
    KURT RICHARD WEISS; Fiscal Year: 2013
    ..Dr. Weiss has also experienced the difficulties of sarcoma surgery which culminated in the amputation of his right leg. This permanent disability has not lessened his desire to discover novel treatments that address the unmet problem ..
  44. The role of HMGB-1 and innate immunity in promoting angiogenesis after ischemia
    Ulka Sachdev; Fiscal Year: 2013
    ..With increasing severity of arterial occlusive disease in the leg, critical limb ischemia can occur resulting in amputation in up to 40% of patients with non-reconstructable disease...
  45. Opioid Activity in Endothelium in Sickle Cell Disease
    Kalpna Gupta; Fiscal Year: 2012
    Non-healing, painful leg ulcers present a major therapeutic challenge in sickle cell disease. We observed that topical application of opioids stimulates angiogenesis and accelerates healing of ischemic wounds in rats...
  46. In Vivo Imaging-Based Multiscale Modeling of Normal and Atrophied Human Lower Leg
    Shantanu Sinha; Fiscal Year: 2013
    ..characterize comprehensively, the multi- component musculoskeletal (MSK) architecture and function of the lower leg, in normal, atrophied and at various stages of recuperation in these subjects and in 8 patients recovering from ..
  47. Developing and Maintaining Physical Fitness in Adolescents with Down Syndrome
    HEIDI ISABEL STANISH; Fiscal Year: 2011
    ..Measures will include 1-RM bench and leg press for muscular strength, maximum repetitions of 50% 1-RM bench and leg press for muscular endurance, 20m ..
  48. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2010
    ..At enrollment, most of these subjects had no more than 30% of normal strength in the affected arm or leg. Despite this success at treating these highly disabled stroke subjects, AMES treatment usually did not restore ..
  49. Effects of early exercise on muscle and cardiovascular health after stroke
    RICHARD FRANK MACKO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stroke leads to profound physical deconditioning and abnormalities in paretic leg muscle including shift to fast twitch muscle phenotype, inflammation and gross atrophy that worsen cardiometabolic ..
  50. Cell therapy for diabetic peripheral neurovascular complications
    YOUNG SUP contact YOON; Fiscal Year: 2011
    ..disease of the lower extremities, and when advanced into the critical limb ischemia stage, can often lead to leg amputation...
  51. Dystonia Coalition
    Hyder A Jinnah; Fiscal Year: 2013
    ..peri-ocular regions), craniofacial dystonia (upper and lower face), and limb dystonias (hand/arm or foot/leg)...
  52. Preventing Venous Leg Ulcers with Cryotherapy: A Randomized Clinical Trial
    Teresa J Kelechi; Fiscal Year: 2013
    ..The goal is to reduce skin blood flow of chronically inflamed skin, decrease the incidence of venous leg ulcers and pain, and improve quality of life...
  53. Molecular Imaging of Retrograde Nerve Transport
    DAWID NONE SCHELLINGERHOUT; Fiscal Year: 2013
    ..We have already shown that we can do Neurography with a fluorescently labeled agent within the sciatic (leg) nerves of mice and that we can use this to show the effects of a toxic chemotherapeutic in common use (oxaliplatin)..
  54. Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD
    Jason David Allen; Fiscal Year: 2013
    ..the US population over 50 yrs, one third of which suffer from intermittent claudication (IC), defined as ischemic leg pain that occurs with walking and improves with rest...
  55. Clinical Trial Planning Grant in Catheter-Directed Thrombolysis of Occlusive DVT
    Marilyn J Manco-Johnson; Fiscal Year: 2013
    ..completely veno-occlusive with IVC involvement in 31% and IVC or iliac involvement in 71%, suggesting that proximal leg DVT is a more severe disorder in children than in adults...
  56. Promoting Physical Activity in Older Adults with Comorbidity
    ELIZABETH ANN SCHLENK; Fiscal Year: 2013
    ..relevant to public health because it examines the modified Staying Active with Arthritis (STAR) program to improve leg exercise, fitness walking, and clinical outcomes (function, blood pressure, leg strength, pain, and health-related ..
  57. A novel rodent model of dopamine agonist-induced impulsive control disorders
    T Celeste Napier; Fiscal Year: 2012
    ..are FDA-approved for the treatment of motor dysfunction in Parkinson's disease (PD) and restless leg syndrome...
  58. Bone marrow-derived fibroblasts in skin wound healing
    Omaida C Velazquez; Fiscal Year: 2010
    ..Overall, we aim to develop new strategies for treating chronic leg wounds by primarily identifying specific molecules, that when expressed by cells within the wound itself, will ..
  59. Reversing Epidermal Stem Cell Aging: Role of Bmi-1 and the Stem Cell Niche
    Ruby Ghadially; Fiscal Year: 2011
    ..g. bedsores, bruising, tearing) and improved treatment of wounds (leg ulcers and slow healing surgical wounds)...
  60. Anatomic Risk Factors for Venous Thromboembolism
    ANAND KUMAR NARAYAN; Fiscal Year: 2010
    ..Since the time of Virchow in the 1800s, investigators have noted that DVT tends to occur more often in the left leg versus the right leg...
  61. Comprehensive Magnetic Resonance in PAD
    Christopher M Kramer; Fiscal Year: 2013
    ..Optimized ASL and quantitative CE-MRI will be used based on Aims 1 and 2, one in each leg. The method of stress for measurement of perfusion will be the most reproducible from Aim 2...
  62. Post-Stroke Contributors to Increased Energetic Cost and Decreased Gait Stability
    JESSE CRAIG DEAN; Fiscal Year: 2012
    ..control strategy to maintain lateral stability is t choose an appropriate mediolateral foot placement of the swing leg, with more lateral foot placement requiring less accurate control...
  63. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 2000
    ..observation has led to the development of a spring-mass model for running, consisting of a single linear massless "leg spring" and a mass...
  64. SKELETAL MUSCLE BEHAVIOR IN HEART FAILURE
    John Wilson; Fiscal Year: 1990
    ..A femoral venous thermodilution catheter will be used to measure leg flow...
  65. Venous Ulcers: Testing Effects of Compression & Position
    Deidre Wipke Tevis; Fiscal Year: 2005
    ..Usual nursing interventions include compression bandages and frequent leg elevation...
  66. PROTEASE MODULATING WOUND DRESSINGS FOR THE TREATMENT OF VENOUS ULCERS
    DAVID VACHON; Fiscal Year: 2006
    ..Approximately 60-80% of chronic leg ulcers have an isolated or predominant venous component and 10-30% of cases are associated with arterial ..
  67. Development of a biodegradable load-bearing DBM carrier
    TIEN MIN CHU; Fiscal Year: 2006
    ..In case of treatment failure, alternative treatment may involve serious consequences such as leg shortening or amputation...
  68. Clinical Implications of Peripheral Plaque Morphology
    Daniel Clair; Fiscal Year: 2007
    ..It is responsible for incapacitating symptoms of leg pain when walking, culminating in amputation in a small proportion of patients...
  69. Central Effects of Acupuncture: Acupoint Specificity
    Ji Fang; Fiscal Year: 2009
    ..brain fMRI is performed during electroacupuncture at St36 (Zusanli),Gb34 (Yanglingquan) and a sham point on the leg, and at Li11(Quchi) on the elbow...
  70. NOVEL ACCESSORY FOR URINARY LEG BAGS
    SHANTHA SARANGAPANI; Fiscal Year: 1999
    Urinary drainage bags called leg bags are commonly used with permanent indwelling catheters in patients, with incontinence or chronic disabilities, at rehabilitation centers or hospitals...
  71. Topical negative pressure dressings for the prevention of chronic wound biofilm
    GUY ORGAMBIDE; Fiscal Year: 2009
    ..A large proportion of patients with chronic wounds, such as diabetic foot ulcers, and venous leg ulcers, are unresponsive to conventional treatment, such as moist dressings...
  72. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Kieren Mather; Fiscal Year: 2003
    ..Basal leg vascular tone and endothelium dependent and independent vasodilation will be assessed with intra-arterial infusion ..
  73. Influence of Ankle Motion on Bilateral Amputee Gait
    Steven Gard; Fiscal Year: 2004
    ..Compared with unilateral amputees, persons with bilateral leg amputations have a greater need for improvement in prosthetic componentry because of their increased energy demand ..
  74. Validation of Measures of Restless Legs Syndrome for Elders with Memory Disorders
    Kathy Richards; Fiscal Year: 2009
    ..RLS is characterized by uncomfortable leg sensations that disturb sleep and are associated with significantly decreased health and cognitive functioning...