knee

Summary

Top Publications

  1. ncbi Activity level and subjective knee function 15 years after anterior cruciate ligament injury: a prospective, longitudinal study of nonreconstructed patients
    Ioannis Kostogiannis
    Department of Orthopaedics, Clinical Sciences, Lund University, Lund, Sweden
    Am J Sports Med 35:1135-43. 2007
  2. ncbi High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury
    L S Lohmander
    Lund University, Lund, Sweden
    Arthritis Rheum 50:3145-52. 2004
  3. doi Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans
    Stephen J Bailey
    School of Sport and Health Sciences, University of Exeter, Heavitree Rd, Exeter EX1 2LU, UK
    J Appl Physiol (1985) 109:135-48. 2010
  4. doi Effect of simultaneous botulinum toxin injections into several muscles on impairment, activity, participation, and quality of life among stroke patients presenting with a stiff knee gait
    Gilles D Caty
    Physical Medicine and Rehabilitation Department, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Stroke 39:2803-8. 2008
  5. pmc The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis
    Eric C Sayre
    Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada
    PLoS ONE 5:e10470. 2010
  6. ncbi Development and validation of the international knee documentation committee subjective knee form
    J J Irrgang
    Department of Physical Therapy, University of Pittsburgh, School of Health and Rehabilitation Sciences, Pennsylvania 15260, USA
    Am J Sports Med 29:600-13. 2001
  7. ncbi A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee
    D D Frisbie
    Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, Ft Collins, Colorado 80525, USA
    Vet Comp Orthop Traumatol 19:142-6. 2006
  8. doi Definition and evaluation of testing scenarios for knee wear simulation under conditions of highly demanding daily activities
    Jens Schwiesau
    Aesculap AG Research and Development, Tuttlingen, Germany
    Med Eng Phys 35:591-600. 2013
  9. doi Aquaporin 1 (AQP1) expression in experimentally induced osteoarthritic knee menisci: an in vivo and in vitro study
    G Musumeci
    Department of Bio Medical Sciences, Section of Human Anatomy and Histology, University of Catania, Catania, Italy
    Tissue Cell 45:145-52. 2013
  10. doi Influence of vibration resistance training on knee extensor and plantar flexor size, strength, and contractile speed characteristics after 60 days of bed rest
    Edwin R Mulder
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University, Amsterdam, The Netherlands
    J Appl Physiol (1985) 107:1789-98. 2009

Detail Information

Publications421 found, 100 shown here

  1. ncbi Activity level and subjective knee function 15 years after anterior cruciate ligament injury: a prospective, longitudinal study of nonreconstructed patients
    Ioannis Kostogiannis
    Department of Orthopaedics, Clinical Sciences, Lund University, Lund, Sweden
    Am J Sports Med 35:1135-43. 2007
    The activity level and subjective knee function after an anterior cruciate ligament (ACL) injury treated without reconstruction have not been well elucidated.
  2. ncbi High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury
    L S Lohmander
    Lund University, Lund, Sweden
    Arthritis Rheum 50:3145-52. 2004
    To determine the prevalence of radiographic knee osteoarthritis (OA) as well as knee-related symptoms and functional limitations in female soccer players 12 years after an anterior cruciate ligament (ACL) injury.
  3. doi Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans
    Stephen J Bailey
    School of Sport and Health Sciences, University of Exeter, Heavitree Rd, Exeter EX1 2LU, UK
    J Appl Physiol (1985) 109:135-48. 2010
    ..The reduced muscle metabolic perturbation with NO(3)(-) supplementation allowed high-intensity exercise to be tolerated for a greater period of time...
  4. doi Effect of simultaneous botulinum toxin injections into several muscles on impairment, activity, participation, and quality of life among stroke patients presenting with a stiff knee gait
    Gilles D Caty
    Physical Medicine and Rehabilitation Department, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Stroke 39:2803-8. 2008
    ..A lack of knee flexion during the swing phase (stiff knee) is one of the impairments that restrict walking ability among patients ..
  5. pmc The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis
    Eric C Sayre
    Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada
    PLoS ONE 5:e10470. 2010
    Osteoarthritis (OA) has a significant impact on individuals' ability to work. Our goal was to investigate the effects of the site of OA (knee, hip, hand, foot, lower back or neck) on employment reduction due to OA (EROA).
  6. ncbi Development and validation of the international knee documentation committee subjective knee form
    J J Irrgang
    Department of Physical Therapy, University of Pittsburgh, School of Health and Rehabilitation Sciences, Pennsylvania 15260, USA
    Am J Sports Med 29:600-13. 2001
    A committee of international knee experts created the International Knee Documentation Committee Subjective Knee Form, which is a knee-specific, rather than a disease-specific, measure of symptoms, function, and sports activity...
  7. ncbi A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee
    D D Frisbie
    Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, Ft Collins, Colorado 80525, USA
    Vet Comp Orthop Traumatol 19:142-6. 2006
    ..condyles of species were used in preclinical studies of articular cartilage and compared to those of the human knee. Cadaver specimens were obtained of six human knees, as well as six equine, six goat, six dog, six sheep and six ..
  8. doi Definition and evaluation of testing scenarios for knee wear simulation under conditions of highly demanding daily activities
    Jens Schwiesau
    Aesculap AG Research and Development, Tuttlingen, Germany
    Med Eng Phys 35:591-600. 2013
    The objective of our study was the definition of testing scenarios for knee wear simulation under various highly demanding daily activities of patients after total knee arthroplasty...
  9. doi Aquaporin 1 (AQP1) expression in experimentally induced osteoarthritic knee menisci: an in vivo and in vitro study
    G Musumeci
    Department of Bio Medical Sciences, Section of Human Anatomy and Histology, University of Catania, Catania, Italy
    Tissue Cell 45:145-52. 2013
    Osteoarthritis (OA) of the knee is a major problem in our society. The development of new treatment options for OA is limited, because the pathophysiological mechanisms are not clearly understood, especially on the molecular level...
  10. doi Influence of vibration resistance training on knee extensor and plantar flexor size, strength, and contractile speed characteristics after 60 days of bed rest
    Edwin R Mulder
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University, Amsterdam, The Netherlands
    J Appl Physiol (1985) 107:1789-98. 2009
    ..Whereas contractile speed improved for the calf, the exercise regimen only partially preserved calf size and MVC strength. Modification of the exercise regimen seems warranted...
  11. pmc The Knee Clinical Assessment Study-CAS(K). A prospective study of knee pain and knee osteoarthritis in the general population: baseline recruitment and retention at 18 months
    George Peat
    Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, ST5 5BG, UK
    BMC Musculoskelet Disord 7:30. 2006
    ..We investigated these matters in the context of baseline recruitment and retention at 18 months of participants for a prospective observational cohort study of knee pain and knee osteoarthritis in the general population.
  12. pmc Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)
    Ali Guermazi
    Department of Radiology, Boston University School of Medicine, FGH Building, 820 Harrison Avenue, Boston, MA 02118, USA
    BMJ 345:e5339. 2012
    ..To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity...
  13. doi Trunk, pelvis, hip, and knee kinematics, hip strength, and gluteal muscle activation during a single-leg squat in males and females with and without patellofemoral pain syndrome
    Theresa H Nakagawa
    Federal University of Sao Carlos, Sao Carlos, SP, Brazil
    J Orthop Sports Phys Ther 42:491-501. 2012
    ..Controlled laboratory study using a cross-sectional design...
  14. doi Training affects knee kinematics and kinetics in cutting maneuvers in sport
    Jodie L Cochrane
    University of Western Australia, Perth, Australia
    Med Sci Sports Exerc 42:1535-44. 2010
    The current study examined how different training affects the kinematics and applied moments at the knee during sporting maneuvers and the potential to reduce loading of the anterior cruciate ligament (ACL)...
  15. ncbi Initial phase of maximal voluntary and electrically stimulated knee extension torque development at different knee angles
    C J de Ruiter
    Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
    J Appl Physiol (1985) 97:1693-701. 2004
    We investigated the capacity for torque development and muscle activation at the onset of fast voluntary isometric knee extensions at 30, 60, and 90 degrees knee angle...
  16. ncbi The effect of anterior cruciate ligament injury on knee joint function under a simulated muscle load: a three-dimensional computational simulation
    Guoan Li
    Orthopaedic Biomechanics Laboratory, Harvard Medical School, Massachusetts General Hospital Beth Israel Deaconess Medical Center, Boston 02215, USA
    Ann Biomed Eng 30:713-20. 2002
    Understanding the biomechanical effect of various factors on knee behavior after anterior cruciate ligament (ACL) injury or reconstruction is instrumental for the development of an optimal surgical treatment of ACL injury that can better ..
  17. doi Medium to long-term results after reconstruction of bone defects at the knee with tumor endoprostheses
    S Kinkel
    Department of Orthopaedics, University of Heidelberg, 69118 Heidelberg, Germany
    J Surg Oncol 101:166-9. 2010
    Limb salvage and reconstruction with tumor endoprostheses is considered as therapeutic standard in the treatment of bone defects at the knee. Few studies report long-term results so far.
  18. doi No difference in knee function or prevalence of osteoarthritis after reconstruction of the anterior cruciate ligament with 4-strand hamstring autograft versus patellar tendon-bone autograft: a randomized study with 10-year follow-up
    Inger Holm
    Division of Rehabilitation, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Am J Sports Med 38:448-54. 2010
    ..The choice of different graft types and surgical techniques used when reconstructing a torn anterior cruciate ligament may influence the long-term prevalence of osteoarthritis and functional outcomes...
  19. doi Effect of graded hypoxia on supraspinal contributions to fatigue with unilateral knee-extensor contractions
    Stuart Goodall
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    J Appl Physiol (1985) 109:1842-51. 2010
    ..output from the motor cortex, accounts for over one-quarter of the force loss after fatiguing contractions of the knee extensors in normoxia...
  20. doi Effects of adding magnesium to bupivacaine and fentanyl for spinal anesthesia in knee arthroscopy
    Hüban Dayioğlu
    Department of Anesthesiology, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey
    J Anesth 23:19-25. 2009
    ..study was to investigate the effects of adding intrathecal magnesium sulfate 50 mg to low-dose bupivacaine-fentanyl on the spread, duration, regression of spinal block, and postoperative analgesia in patients undergoing knee arthroscopy.
  21. ncbi The hemodynamic and metabolic effects of tourniquet application during knee surgery
    M Girardis
    Cattedra di Anestesiologia e Rianimazione and Cattedra di Fisiologia Umana, Universita Degli Studi di Udine, Italy
    Anesth Analg 91:727-31. 2000
    ..the effects of tourniquet application on the cardiovascular system and metabolism in 10 young men undergoing knee surgery with general anesthesia. The duration of inflation was from 75 to 108 min...
  22. ncbi Influence of medial hamstring tendon harvest on knee flexor strength after anterior cruciate ligament reconstruction. A detailed evaluation with comparison of single- and double-tendon harvest
    Toshiyuki Tashiro
    Department of Orthopaedic Surgery, Tokyo Teishin Hospital, Tokyo, Japan
    Am J Sports Med 31:522-9. 2003
    The advantages of hamstring tendon autografts for anterior cruciate ligament reconstruction are well known; however, concerns have arisen regarding the influence of hamstring tendon harvest on postoperative weakness in knee flexion.
  23. pmc Selective stimulation of the human femoral nerve with a flat interface nerve electrode
    M A Schiefer
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
    J Neural Eng 7:26006. 2010
    ..Of these, at least one muscle was a hip flexor and at least two were knee extensors...
  24. doi Reduction in knee adduction moment via non-invasive biomechanical training: a longitudinal gait analysis study
    Amir Haim
    Biorobotics and Biomechanics Lab, Technion Israel Institute of Technology, Haifa, Israel
    J Biomech 45:41-5. 2012
    ..have been previously reported to reduce pain and facilitate superior levels of function in patients with medial knee osteoarthritis [OA]...
  25. pmc Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data
    Uyen Sa D T Nguyen
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Ann Intern Med 155:725-32. 2011
    A recent surge in knee replacements is assumed to be due to aging and increased obesity of the U.S. population.
  26. doi Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial
    Amy S Chappell
    Lilly Research Laboratories, Indianapolis, IN, USA
    Pain 146:253-60. 2009
    ..randomized, double-blind, placebo-controlled trial of duloxetine (60-120 mg/day) versus placebo in the treatment of knee pain in 231 patients meeting clinical and radiographic criteria for osteoarthritis of the knee...
  27. doi Duloxetine added to oral nonsteroidal anti-inflammatory drugs for treatment of knee pain due to osteoarthritis: results of a randomized, double-blind, placebo-controlled trial
    ELIJAH P FRAKES
    Eli Lilly and Company, Indianapolis, IN, USA
    Curr Med Res Opin 27:2361-72. 2011
    To determine the efficacy, tolerability, and safety of duloxetine when added to oral nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis (OA) of the knee with pain of moderate or greater severity.
  28. pmc Single-legged hop tests as predictors of self-reported knee function in nonoperatively treated individuals with anterior cruciate ligament injury
    Hege Grindem
    Norwegian Research Center for Active Rehabilitation, Hjelp24 Norwegian Sports Medicine Clinic, Ulleval Stadion, Norway
    Am J Sports Med 39:2347-54. 2011
    ..Previous studies have found significant predictors for functional outcome after anterior cruciate ligament (ACL) reconstruction; however, studies examining predictors for functional outcome in nonoperatively treated individuals are lacking...
  29. ncbi Surface EMG crosstalk between knee extensor muscles: experimental and model results
    Dario Farina
    Dipartimento di Elettronica, Centro di Bioingegneria, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy
    Muscle Nerve 26:681-95. 2002
    ..This study clarifies many controversial findings of past investigations and creates the basis for crosstalk interpretation, simulation, and reduction...
  30. doi Muscle activity differs with load compliance during fatiguing contractions with the knee extensor muscles
    Thorsten Rudroff
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Exp Brain Res 203:307-16. 2010
    ..influence of load compliance on the time to failure and rate of change in electromyographic (EMG) activity when the knee extensor muscles performed fatiguing contractions against submaximal loads...
  31. pmc The John Insall Award: Both morphotype and gender influence the shape of the knee in patients undergoing TKA
    Johan Bellemans
    University Hospitals of the Catholic University, Leuven, Belgium
    Clin Orthop Relat Res 468:29-36. 2010
    There is an ongoing debate whether gender differences in the dimensions of the knee should influence the design of TKA components...
  32. ncbi Comparison of the angles and corresponding moments in the knee and hip during restricted and unrestricted squats
    Silvio Lorenzetti
    Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
    J Strength Cond Res 26:2829-36. 2012
    The aim of this study was to compare the angles and corresponding moments in the knee and hip during squats. Twenty subjects performed restricted and unrestricted squats with barbell loads that were 0, ¼, and ½ their body weight...
  33. doi Prevalence of reported knee pain over twelve years in a community-based cohort
    A Soni
    University of Oxford, Oxford, UK
    Arthritis Rheum 64:1145-52. 2012
    To describe the temporal patterns of knee pain in a community-based cohort over 12 years.
  34. doi Age- and sex-associated differences in isokinetic knee muscle endurance between young children and adults
    Mark B A De Ste Croix
    Department of Sport and Exercise, University of Gloucestershire, Gloucester GL2 9HW, UK
    Appl Physiol Nutr Metab 34:725-31. 2009
    The purpose of this study was to examine the age- and sex-associated differences of repeated isokinetic knee extension and flexion...
  35. ncbi Effects of different methods of antagonist muscles pre-activation on knee extensors neuromuscular responses
    Rodrigo L Carregaro
    Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
    Rev Bras Fisioter 15:452-9. 2011
    ..Pre-activation of antagonistic muscles is used in different modalities of exercise and neuromuscular rehabilitation protocols, but its effectiveness is still controversial...
  36. pmc Abnormal coactivation of knee and ankle extensors is related to changes in heteronymous spinal pathways after stroke
    Joseph Omer Dyer
    Centre de recherche interdisciplinaire en réadaptation du Montréal métropolitain, Institut de réadaptation Gingras Lindsay de Montréal, Montreal, Canada
    J Neuroeng Rehabil 8:41. 2011
    ....
  37. pmc Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: the Women's Health and Aging Study II
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 58:2076-84. 2010
    ..To assess the relationship between rate of change in muscle strength and all-cause mortality...
  38. pmc The Knee Clinical Assessment Study--CAS(K). A prospective study of knee pain and knee osteoarthritis in the general population
    George Peat
    Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, United Kingdom ST5 5BG
    BMC Musculoskelet Disord 5:4. 2004
    b>Knee pain affects an estimated 25% of the adult population aged 50 years and over. Osteoarthritis is the most common diagnosis made in older adults consulting with knee pain in primary care...
  39. pmc Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise
    Daniel T Cannon
    Rehabilitation Clinical Trials Center, Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California
    J Appl Physiol (1985) 115:839-49. 2013
    ..spectroscopy, chemical shift imaging, and T2-weighted imaging with pulmonary oxygen uptake during bilateral knee-extension exercise to intolerance...
  40. doi Importance of preswing rectus femoris activity in stiff-knee gait
    Jeffrey A Reinbolt
    Department of Bioengineering, Stanford University, Clark Center, Room S 322, Mail Code 5450, 318 Campus Drive, Stanford, CA 94305 5450, USA
    J Biomech 41:2362-9. 2008
    Stiff-knee gait is characterized by diminished and delayed knee flexion during swing...
  41. pmc Prevalence of self-reported pain, joint complaints and knee or hip complaints in adults aged ≥ 40 years: a cross-sectional survey in Herne, Germany
    Ulrich Thiem
    Department of Geriatrics, University of Bochum, Marienhospital Herne, Herne, Germany
    PLoS ONE 8:e60753. 2013
    ..Despite their epidemiological, clinical and health economic importance, prevalence data on pain and musculoskeletal complaints for Germany are scarce...
  42. doi Knee acoustic emission: a potential biomarker for quantitative assessment of joint ageing and degeneration
    L K Shark
    Applied Digital Signal and Image Processing Research Centre, University of Central Lancashire, Preston, PR1 2HE, UK
    Med Eng Phys 33:534-45. 2011
    ..knees in three different age groups (early, middle and late adulthood), this paper reports the potential of knee acoustic emission as a biomarker to monitor joint ageing and degeneration...
  43. pmc Relationship between knee and ankle degeneration in a population of organ donors
    Carol Muehleman
    Department of Biochemistry, Rush University Medical Center, Cohn Research Building, 1735 W Harrison, Chicago, IL 60612, USA
    BMC Med 8:48. 2010
    ..The relationship of OA in one joint of an extremity to another joint within the same extremity, or between extremities, has been a topic of interest in reference to the etiology and/or progression of the disease...
  44. doi Mood and attitude predict pain outcomes following arthroscopic knee surgery
    Patricia H Rosenberger
    VA Connecticut Healthcare System, 950 Campbell Avenue, Psychology 116B, West Haven, CT 06516, USA
    Ann Behav Med 37:70-6. 2009
    Decreased pain represents a clinically important outcome following arthroscopic knee surgery. However, little is known about preoperative mood and attitudinal factors and their potential relationship with pain outcomes.
  45. doi Increase in outpatient knee arthroscopy in the United States: a comparison of National Surveys of Ambulatory Surgery, 1996 and 2006
    Sunny Kim
    Department of Orthopaedic Surgery, University of California Davis, 4860 Y Street, Suite 3800, Sacramento, CA 95817, USA
    J Bone Joint Surg Am 93:994-1000. 2011
    This study was proposed to investigate the changes in the utilization of knee arthroscopy in an ambulatory setting over the past decade in the United States as well as its implications.
  46. doi Total knee arthroplasty with use of computer-assisted navigation compared with conventional guiding systems in the same patient: radiographic results in Asian patients
    Tsan Wen Huang
    Division of Sports Medicine, Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chia Yi, Taiwan
    J Bone Joint Surg Am 93:1197-202. 2011
    The value of computer-assisted surgery in total knee arthroplasty for arthritic knees continues to be debated...
  47. ncbi Knee extensor fatigability after bedrest for 8 weeks with and without countermeasure
    Edwin R Mulder
    Radboud University Nijmegen Medical Center, Department of Clinical Neurophysiology, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Muscle Nerve 36:798-806. 2007
    ..Changes in knee extensor fatigability as a consequence of 8 weeks of horizontal bedrest with or without daily resistive vibration ..
  48. pmc Strength characterization of knee flexor and extensor muscles in Prader-Willi and obese patients
    Paolo Capodaglio
    Orthopaedic Rehabilitation Unit and Clinical Lab for Gait Analysis and Posture, Ospedale San Giuseppe, Istituto Auxologico Italiano IRCCS, Piancavallo Verbania, Italy
    BMC Musculoskelet Disord 10:47. 2009
    ..The aim of our study was to characterize the lower limb muscle function of patients affected by PWS as compared to non-syndromal obesity and normal-weight subjects...
  49. pmc The effects of femoral graft placement on in vivo knee kinematics after anterior cruciate ligament reconstruction
    E S Abebe
    Sports Medicine Center, Department of Orthopaedic Surgery, Box 3093, Duke University Medical Center, Durham, NC 27710, USA
    J Biomech 44:924-9. 2011
    ..study was to quantify the effect of femoral graft placement on the ability of ACL reconstruction to restore normal knee kinematics under in vivo loading conditions...
  50. doi Dynamic finite element knee simulation for evaluation of knee replacement mechanics
    Mark A Baldwin
    Computational Biomechanics Lab, University of Denver, Denver, CO 80208, USA
    J Biomech 45:474-83. 2012
    In vitro pre-clinical testing of total knee replacement (TKR) devices is a necessary step in the evaluation of new implant designs...
  51. ncbi Cutaneous receptors contribute to kinesthesia at the index finger, elbow, and knee
    D F Collins
    Human Neurophysiology Laboratory, Faculty of Physical Education and Recreation, Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    J Neurophysiol 94:1699-706. 2005
    ..Illusory movements were evoked at the interphalangeal (IP) joints of the index finger, the elbow, and the knee by stimulation of populations of cutaneous and muscle spindle receptors, both separately and together...
  52. ncbi The biomechanical effects of focused muscle training on medial knee loads in OA of the knee: a pilot, proof of concept study
    L E Thorp
    Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
    J Musculoskelet Neuronal Interact 10:166-73. 2010
    High dynamic loads of the medial knee are associated with tibiofemoral osteoarthritis (OA) severity and progression...
  53. ncbi Virtual reality simulation of arthroscopy of the knee
    Jay D Mabrey
    American Academy of Orthopaedic Surgeons, Council on Education Task Force on Virtual Reality, USA
    Arthroscopy 18:E28. 2002
    The virtual reality arthroscopic knee simulator (VR-AKS) consists of a computer platform, a video display, and two force-feedback (haptic) interfaces known as "PHANToMs" that also monitor the position of the instruments in the user's ..
  54. doi MR imaging of entrapment neuropathies of the lower extremity. Part 2. The knee, leg, ankle, and foot
    Andrea Donovan
    Department of Radiology, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada
    Radiographics 30:1001-19. 2010
    Entrapment neuropathies of the knee, leg, ankle, and foot are often underdiagnosed, as the results of clinical examination and electrophysiologic evaluation are not always reliable...
  55. ncbi Navigation as a predictor of soft tissue release during 90 cases of computer-assisted total knee arthroplasty
    Dominique Saragaglia
    Department of Orthopedic Surgery and Sport Traumatology, Greonoble University South Teaching Hospital, Echirolles, France
    Orthopedics 29:S137-8. 2006
    Soft tissue balance during total knee arthroplasty (TKA) procedures may be challenging to achieve in knees with severe valgus or varus deformities...
  56. ncbi The MRI appearance of cystic lesions around the knee
    Catherine L McCarthy
    Department of Radiology, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, OX3 7LD, UK
    Skeletal Radiol 33:187-209. 2004
    This review presents a comprehensive illustrated overview of the wide variety of cystic lesions around the knee. The aetiology, clinical presentation, MRI appearances and differential diagnosis are discussed...
  57. pmc Intensive lifestyle intervention improves physical function among obese adults with knee pain: findings from the Look AHEAD trial
    Capri G Foy
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 19:83-93. 2011
    ..investigation involved participants in the Action for Health in Diabetes (Look AHEAD) trial who reported knee pain at baseline (n = 2,203)...
  58. doi Effects of neuromuscular electrical stimulation on muscle layer thickness of knee extensor muscles in intensive care unit patients: a pilot study
    Wolfgang Gruther
    Joint and Bone Center Center for Diagnosis, Research and Therapy of Musculoskeletal Disorders, Medical University of Vienna, Vienna, Austria
    J Rehabil Med 42:593-7. 2010
    ..The aim of this study was to evaluate the effects of neuromuscular electrical stimulation on muscle layer thickness of knee extensor muscles in intensive care unit patients.
  59. doi Postoperative deep infection in tumor endoprosthesis reconstruction around the knee
    Takeshi Morii
    Department of Orthopaedic Surgery, Kyorin University, Tokyo, Japan
    J Orthop Sci 15:331-9. 2010
    ....
  60. doi Evaluating the responsiveness of the ICOAP following hip or knee replacement
    A M Davis
    Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, Toronto, Canada
    Osteoarthritis Cartilage 18:1043-5. 2010
    ..The purpose of this study was to evaluate the responsiveness of the ICOAP, and different pain constructs in primary total hip (THR) and total knee (TKR) replacement.
  61. ncbi Knee muscle activity during ambulation of trans-tibial amputees
    E Isakov
    Orthopedic Rehabilitation Department, Loewenstein Hospital, Ra anana, Israel
    J Rehabil Med 33:196-9. 2001
    ..05) smaller ratio (0.22) compared with the sound leg (0.83). The use of prosthesis in trans-tibial amputees requires further activity of the biceps femoris during stance period to improve support of the amputated leg knee joint.
  62. ncbi Knee extension strength cutpoints for maintaining mobility
    Todd M Manini
    Institute on Aging, Department of Aging and Geriatric Research, Amsterdam, The Netherlands
    J Am Geriatr Soc 55:451-7. 2007
    To identify levels of knee extensor strength that are associated with high and low risk of incident severe mobility limitation (SML) in initially well-functioning older adults.
  63. pmc Gait after unilateral total knee arthroplasty: frontal plane analysis
    Ali H Alnahdi
    Graduate Program in Biomechanics and Movement Science, University of Delaware, 301 McKinly Lab, Newark, Delaware 19716, USA
    J Orthop Res 29:647-52. 2011
    After unilateral total knee arthroplasty (TKA), osteoarthritis (OA) in the non-operated knee often progresses...
  64. pmc Baseline articular contact stress levels predict incident symptomatic knee osteoarthritis development in the MOST cohort
    Neil A Segal
    Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, Iowa, USA
    J Orthop Res 27:1562-8. 2009
    We studied whether contact stress estimates from knee magnetic resonance images (MRI) predict the development of incident symptomatic tibiofemoral osteoarthritis (OA) 15 months later in an at-risk cohort...
  65. ncbi Function of posterior cruciate ligament bundles during in vivo knee flexion
    Ramprasad Papannagari
    Bioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Sports Med 35:1507-12. 2007
    The biomechanical functions of the anterolateral and posteromedial bundles of the posterior cruciate ligament over the range of flexion of the knee joint remain unclear.
  66. ncbi Exercise, self-efficacy, and mobility performance in overweight and obese older adults with knee osteoarthritis
    Brian C Focht
    Ohio State University, Columbus, 43210, USA
    Arthritis Rheum 53:659-65. 2005
    ..self efficacy following exercise and dietary weight loss interventions in overweight and obese older adults with knee osteoarthritis (OA), and to determine if self efficacy and pain mediate the effects of the interventions on ..
  67. ncbi Knee extension strength and body weight determine sit-to-stand independence after stroke
    Richard W Bohannon
    Department of Physical Therapy, University of Connecticut, Neag School of Education, University of Connecticut, Storrs, CT 06269 2101, USA
    Physiother Theory Pract 23:291-7. 2007
    ..This study sought to determine the importance of knee extension force and body weight to independence in STS...
  68. ncbi The female knee: anatomic variations
    Sheryl Conley
    Americas and Global Marketing
    J Am Acad Orthop Surg 15:S31-6. 2007
    Traditional knee implants have been designed "down the middle,"based on the combined average size and shape of male and female knee anatomy...
  69. ncbi Influence of concentric and eccentric resistance training on architectural adaptation in human quadriceps muscles
    Anthony J Blazevich
    Centre for Sports Medicine and Human Performance, School of Sport and Education, Brunel Univ, Uxbridge UB8 3PH, UK
    J Appl Physiol (1985) 103:1565-75. 2007
    ..men and women performed slow-speed (30 degrees /s) concentric-only (Con) or eccentric-only (Ecc) isokinetic knee extensor training for 10 wk before completing a 3-mo detraining period...
  70. ncbi Human femoral artery diameter in relation to knee extensor muscle mass, peak blood flow, and oxygen uptake
    G Radegran
    Copenhagen Muscle Research Centre, Rigshospitalet, DK 2200 Copenhagen N, Denmark
    Am J Physiol Heart Circ Physiol 278:H162-7. 2000
    ..90 +/- 0.31 (range 2.29-5.03) l/min during ergometer cycle exercise, performed one-legged dynamic knee extensor exercise up to peak effort at 68 +/- 7 W (range 55-100 W)...
  71. ncbi Relationship of knee extension force to independence in sit-to-stand performance in patients receiving acute rehabilitation
    Ola Eriksrud
    Wilton Physical Therapy, Wilton, Conn, USA
    Phys Ther 83:544-51. 2003
    ..This study was conducted to determine to what extent knee extension force (KEF) could explain independence in sit-to-stand (STS) performance from a standard chair.
  72. ncbi Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery
    K A Bauer
    Department of Medicine, Veterans Affairs Boston Healthcare System and Beth Israel Deaconess Medical Center, MA 02215, USA
    N Engl J Med 345:1305-10. 2001
    Despite thromboprophylaxis, major knee surgery carries a high risk of venous thromboembolism. Fondaparinux, the first of a new class of synthetic antithrombotic agents, may reduce this risk.
  73. pmc The Chitranjan Ranawat Award: The nonoperated knee predicts function 3 years after unilateral total knee arthroplasty
    Sara Farquhar
    Department of Physical Therapy, University of Delaware, Newark, DE 19716, USA
    Clin Orthop Relat Res 468:37-44. 2010
    The long-term functional abilities of patients after a unilateral total knee arthroplasty (TKA) are influenced by the status of the nonoperated knee at the time of the TKA...
  74. ncbi The difference in trochlear orientation between the natural knee and current prosthetic knee designs; towards a truly physiological prosthetic groove orientation
    M Barink
    Orthopaedic Research Lab, Department of Orthopaedics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomech 39:1708-15. 2006
    The patella groove of total knee replacements has evolved from a groove with a neutral orientation to a groove with a lateral (also referred to as valgus) orientation...
  75. ncbi Reproducibility of measurement of femoral component rotation after total knee arthroplasty using computer tomography
    Thomas Suter
    Department of Orthopaedic Surgery, University of Zurich, Balgrist, Switzerland
    J Arthroplasty 21:744-8. 2006
    ..CTA) and the posterior condylar angle (PCA) describe rotational alignment of the femoral component after total knee arthroplasty...
  76. ncbi The effects of adding mass to the legs on the energetics and biomechanics of walking
    Raymond C Browning
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80262, USA
    Med Sci Sports Exerc 39:515-25. 2007
    ....
  77. doi A subject specific multibody model of the knee with menisci
    Trent M Guess
    Mechanical Engineering, University of Missouri Kansas City, 350K Flarsheim Hall, 5100 Rockhill Road, Kansas City, MO 64110 2499, USA
    Med Eng Phys 32:505-15. 2010
    The menisci of the knee play an important role in joint function and our understanding of knee mechanics and tissue interactions can be enhanced through computational models of the tibio-menisco-femoral structure...
  78. ncbi MR imaging of cysts, ganglia, and bursae about the knee
    Francesca D Beaman
    Center Radiology, PC, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, USA
    Magn Reson Imaging Clin N Am 15:39-52. 2007
    Cystic lesions around the knee comprise a diverse group of entities, ranging from benign cysts to complications of underlying diseases such as infection, arthritis, and malignancy...
  79. ncbi Comparison of muscle strength and flexibility between the preferred and non-preferred leg in English soccer players
    Nader Rahnama
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, 15 21 Webster Street, Liverpool L3 2ET, UK
    Ergonomics 48:1568-75. 2005
    ..81 +/- 0.06 m; body mass 81.7 +/- 9.9 kg) were studied (data are presented as mean +/- SD). The dynamic strength of knee flexors (hamstrings) and knee extensors (quadriceps) was measured using an isokinetic dynamometer at angular ..
  80. ncbi Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees
    Shigeyuki Wakitani
    Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Tissue Eng Regen Med 1:74-9. 2007
    ..Autologous bone marrow mesenchymal cells transplantation may be an effective approach to promote the repair of articular cartilage defects...
  81. ncbi Reliability of hand-held dynamometry in assessment of knee extensor strength after hip fracture
    Marc Andre Gilles Roy
    School of Kinesiology, University of Western Ontario, London, Ontario, Canada
    Am J Phys Med Rehabil 83:813-8. 2004
    To examine the reliability of hand-held dynamometry in assessing knee extensor strength in inpatients undergoing rehabilitation after hip fracture and to examine the discriminant validity of this measure.
  82. ncbi Strength and power changes of the human plantar flexors and knee extensors in response to resistance training in old age
    A Ferri
    Centro Studi Attività Motorie CSAM, Fondazione S Maugeri, Clinica del Lavoro e della Riabilitazione, IRCCS, Pavia, Italy
    Acta Physiol Scand 177:69-78. 2003
    ..The aim of the present study was to assess and compare the improvements of muscle strength and power induced by a 16-week resistive programme in a population of 16 older men aged 65-81 years...
  83. doi Determinants of hand grip strength, knee extension strength and functional status in cancer patients
    Kristina Norman
    Charité Universitätsmedizin Berlin Campus Mitte, Dept of Gastroenterology, Germany
    Clin Nutr 29:586-91. 2010
    Decreased functionality and muscle weakness are prominent features in cancer patients. We investigated determinants of muscle function assessed by hand grip and knee extension strength as well as functional status in cancer patients.
  84. doi Locomotor exercise induces long-lasting impairments in the capacity of the human motor cortex to voluntarily activate knee extensor muscles
    Simranjit K Sidhu
    University of New South Wales, Sydney, Australia
    J Appl Physiol (1985) 106:556-65. 2009
    ..Brief (2 s) and sustained (30 s) isometric knee extension contractions were completed before and after locomotor exercise consisting of eight, 5-min bouts of ..
  85. doi Hip strength and hip and knee kinematics during stair descent in females with and without patellofemoral pain syndrome
    Lori A Bolgla
    Medical College of Georgia, School of Allied Health Sciences, Department of Physical Therapy, Augusta, GA, USA
    J Orthop Sports Phys Ther 38:12-8. 2008
    ..Cross-sectional...
  86. ncbi Differences in size, strength, and power of upper and lower body muscle groups in young and older men
    Darren G Candow
    87 Campus Drive, College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5B2
    J Gerontol A Biol Sci Med Sci 60:148-56. 2005
    ..05 rad/s and 3.14 rad/s in flexor and extensor muscles of the elbow and knee, and in ankle plantar flexors in young (n=22, 18-31 years) and older (n=28, 59-76 years) men...
  87. doi Volitional control of a prosthetic knee using surface electromyography
    Kevin H Ha
    Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Biomed Eng 58:144-51. 2011
    This paper presents a method for providing volitional control of a powered knee prosthesis during nonweight-bearing activity such as sitting...
  88. ncbi Reduction of spastic hypertonia during repeated passive knee movements in stroke patients
    Godelieve E Nuyens
    Department of Rehabilitation Sciences, Faculty of Physical Education and Physiotherapy, University of Leuven, Belgium
    Arch Phys Med Rehabil 83:930-5. 2002
    To quantify changes in spastic hypertonia during repeated passive isokinetic knee movements in stroke patients and to assess the role of muscle activity.
  89. ncbi Knee muscle isometric strength, voluntary activation and antagonist co-contraction in the first six months after stroke
    D J Newham
    Applied Biomedical Research Group, School of Biomedical Sciences, King s College London, UK
    Disabil Rehabil 23:379-86. 2001
    ..We investigated voluntary isometric strength, activation and the extent of co-contraction in the knee muscles during the first six months during stroke.
  90. doi Effectiveness of medial-wedge insole treatment for valgus knee osteoarthritis
    Priscilla T Rodrigues
    School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Arthritis Rheum 59:603-8. 2008
    To assess the efficacy of medial-wedge insoles in valgus knee osteoarthritis (OA).
  91. ncbi Compliant walking in primates: elbow and knee yield in primates compared to other mammals
    Eileen Larney
    Interdepartmental Doctoral Program in Anthropological Sciences, Stony Brook University, Stony Brook, New York 11794 4364, USA
    Am J Phys Anthropol 125:42-50. 2004
    ..In order to explore the generality of this claim, elbow and knee angles during walking were documented at touchdown, midstance, and liftoff in a sample of primates, carnivores, ..
  92. doi MRI features of cystic lesions around the knee
    Monica D Marra
    Department of Radiology, Boston University Medical Center, FGH Building, 3rd Floor, 820 Harrison Ave, Boston, MA 02118, United States
    Knee 15:423-38. 2008
    Cystic lesions around the knee are a diverse group of entities, frequently encountered during routine MRI of the knee...
  93. ncbi Which patients with osteoarthritis of hip and/or knee benefit most from behavioral graded activity?
    Cindy Veenhof
    NIVEL Netherlands Institute for Health Services Research, Utrecht, The Netherlands
    Int J Behav Med 14:86-91. 2007
    ..Two hundred participants with OA of hip or knee, or both (clinical American College of Rheumatology, ACR, criteria) participated in a randomized clinical trial on ..
  94. ncbi Cystic masses of the knee: magnetic resonance imaging findings
    Douglas P Beall
    Department of Radiological Sciences, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA
    Curr Probl Diagn Radiol 34:143-59. 2005
    Cystic masses of the knee comprise a diverse group of pathologic entities ranging from simple cysts to complications of underlying disease to tumors...
  95. ncbi Measuring knee extensor muscle strength
    R W Bohannon
    Department of Physical Therapy, School of Allied Health, University of Connecticut, Storrs 06269-2101, USA
    Am J Phys Med Rehabil 80:13-8. 2001
    OBJECTIVE: To compare manual muscle test with hand-held dynamometer measurements of knee extension strength. A secondary analysis of measurements (n = 256 knees) from 128 acute rehabilitation patients was performed...
  96. pmc Knee complaints vary with age and gender in the adult population. Population-based reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS)
    Przemyslaw T Paradowski
    Department of Orthopedics, Clinical Sciences, Lund University Hospital, SE 221 85 Lund, Sweden
    BMC Musculoskelet Disord 7:38. 2006
    Self-reported knee complaints may vary with age and gender. Reference data from the adult population would help to better interpret the outcome of interventions due to knee complaints...
  97. ncbi Excision of heterotopic ossification from the knee: a functional outcome study
    David A Fuller
    Moss Rehab Hospital, Philadelphia, PA, USA
    Clin Orthop Relat Res 438:197-203. 2005
    ..Our primary research goal was to determine the change in range of motion at the knee after resection of heterotopic ossification in patients with neurologic injuries...
  98. ncbi Women have increased rates of cartilage loss and progression of cartilage defects at the knee than men: a gender study of adults without clinical knee osteoarthritis
    Fahad S Hanna
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Victoria, Australia
    Menopause 16:666-70. 2009
    Women have an increased risk of knee osteoarthritis (OA). However, little is known about gender differences in cartilage health before the onset of clinical knee OA...
  99. doi Anterior knee pain and cold knees: a possible association in women
    James Selfe
    School of Public Health and Clinical Sciences, University of Central Lancashire, Preston, Lancashire, United Kingdom
    Knee 17:319-23. 2010
    Abnormal reactions to environmental cold have been observed in some patients with Anterior Knee Pain (AKP)...
  100. pmc Does total knee arthroplasty change frontal plane knee biomechanics during gait?
    Karl F Orishimo
    Nicholas Institute of Sports Medicine and Athletic Trauma, Lenox Hill Hospital, 100 E 77th Street, 2nd Floor, New York, NY 10075, USA
    Clin Orthop Relat Res 470:1171-6. 2012
    Dynamic knee varus angle and adduction moments have been reported to be reduced after TKA. However, it is unclear whether this reduction is maintained long term.
  101. pmc Principles of brain plasticity in improving sensorimotor function of the knee and leg in healthy subjects: a double-blind randomized exploratory trial
    Eva Ageberg
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Sweden
    BMC Musculoskelet Disord 10:99. 2009
    ..Training is included in the treatment of knee injury to improve both patient-reported function and sensorimotor function...

Research Grants78

  1. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..is a disease with flakey skin, and can be associated with arthritis of joints of hands, wrist, feet, ankle, knee, and spine...
  2. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..In a pilot work, we provided evidence that evoked RT using surface neuromuscular electrical stimulation (NMES) for knee extensor muscle group resulted in significant increase skeletal muscle cross-sectional area (CSA), reduction in % ..
  3. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ..The annual estimated out-of-pocket cost per patient for the management of knee OA alone is estimated to be $2600 with total annual expenses estimated to be $5700...
  4. Effectiveness and Safety of Antithrombotic Strategies after Joint Replacement
    Elaine Hylek; Fiscal Year: 2013
    ..Without prophylaxis, the prevalence of VTE following hip or knee arthroplasty is 40-60%...
  5. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ..supplements to study effects upon autoimmune disease incidence, biomarkers of systemic inflammation, and chronic knee pain...
  6. Arm Exercise versus Other Stress Test Modalities for Clinical Outcome Prediction
    WADE HAMPTON MARTIN; Fiscal Year: 2013
    ..for patients who undergo pharmacologic stress tests because of lower extremity disabilities such as amputations, knee or other arthropathies, myopathies, claudication, spinal cord, or combat injuries...
  7. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    ..collagen haploinsufficient mice (heterozygous chondrodysplasia, cho/+) mice develop progressive OA-like changes in knee and temporomandibular (TM) joints;(2) the levels of expression and activity of matrix metalloproteinase 13 (MMP-13, ..
  8. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    ..test the hypothesis that "oral consumption of PFE inhibits cartilage degradation and suppresses the progression of knee OA in rabbits induced by anterior cruciate ligament transection (ACLT)"...
  9. Improving ambulatory community access after paralysis
    Rudi Kobetic; Fiscal Year: 2012
    ..These include individuals with weak hip and knee flexors and ankle dorsiflexors for initiating a step and weak hip flexors, ankle plantar flexor and hip extensors ..
  10. Characterizing Patellofemoral Joint Stress Using Patient-Specific Models
    GARY BEAUPRE; Fiscal Year: 2012
    ..pain, also called patellofemoral syndrome, is recognized as the most common musculoskeletal condition involving the knee and the number one musculoskeletal diagnosis among adults between the ages of 25 and 40 years who participate in ..
  11. 3D Single Fiber Endoscope for Minimally Invasive Surgeries
    Jason Geng; Fiscal Year: 2013
    ..nerves, interventional cardiology procedures of balloon angioplasty and stenting;arthroscopic procedures, including knee, shoulder, small joint and hips;and laparoscopic procedures to examine, diagnose and treat problems of the abdomen...
  12. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    David Stump; Fiscal Year: 2013
    ..We will also determine whether knee prosthesis surgery using a state of the art reaming system, with chilling and rinse- vacuum methodology is safer ..
  13. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    William Brown; Fiscal Year: 2009
    ..We will also determine whether knee prosthesis surgery using a state of the art reaming system, with chilling and rinse- vacuum methodology is safer ..
  14. Central Nervous System Mechanisms in Knee Osteoarthritis (KOA)
    Daniel J Clauw; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Recent studies suggest the lifetime risk for symptomatic knee OA (KOA) is 45%1. An aging population and increasing rates of obesity contribute to dramatic increases in the prevalence of this condition...
  15. A new experimental model of knee joint trauma
    TAMMY L HAUTDONAHUE; Fiscal Year: 2012
    ..Treatment of these injuries, particularly to the knee joint, is paramount in the retention of a healthy lifestyle...
  16. The Toll-like receptor pathway in Meniscal Injury and Osteoarthritis
    CARLA ROSE SCANZELLO; Fiscal Year: 2013
    ..that the pro-inflammatory cytokine interleukin-15 (IL-15) is detectable in the joints of most patients with knee OA seeking surgical intervention for both early and advanced disease7...
  17. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..The menisci of the knee perform several important functions including increasing the contact area between the incongruent articular ..
  18. BMP2 signaling of the development of osetoarthritis
    Vicki Rosen; Fiscal Year: 2013
    ..the limb skeleton and an ability to initiate fracture repair (22-24) and the progressive development of OA of the knee, elbow, wrist and ankle by 28 weeks of age (Fig 1)...
  19. Predicting cell deformation from body level mechanical loads
    Ahmet Erdemir; Fiscal Year: 2012
    ..Multiresolution models of the knee joint, representative of joint, tissue and cell structure and mechanics, will be developed for this purpose...
  20. Effect of Articular Neurotoxin on Joint Pain and Neurochemical Signature
    Maren Lawson Mahowald; Fiscal Year: 2012
    ..These models will be produced by injecting mouse knee joints with carrageenan, and Complete Freund's Adjuvant and by destabilizing the medial meniscus of the knee ..
  21. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2012
    ..of the Developing Chick Elbow Joint Project Summary Synovial joints such as those that comprise the elbow, knee, and hip are extremely important for functioning in everyday life...
  22. The Johnston County OA Project: Arthritis and Disability
    Joanne M Jordan; Fiscal Year: 2013
    ..this study will provide long-term outcome data for the prevalence, incidence and progression of radiographic knee and hip OA, knee and hip symptoms, and disability in African Americans and Whites, aged 45 years and older...
  23. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen T Bishop; Fiscal Year: 2012
    ..healing potential and function of orthotopic whole joint composite tissue transplants in a larger animal (rabbit knee) model...
  24. System for Tracking and Managing Pain (STAMP)
    Wendy A Rogers; Fiscal Year: 2012
    ..STAMP will be a patient-centered pain experience education and management tool for older adults with OA knee and/or hip pain...
  25. Comparative Effectiveness of Customary Fit and Strong! vs. Fit and Strong! Plus
    Susan L Hughes; Fiscal Year: 2013
    ..Data show that a weight loss of 5.1 kg over a 10-year period decreases the odds of developing knee OA by more than 50% (Felson 1992)...
  26. Phase-contrast X-ray imaging system for large joints
    Dan Stutman; Fiscal Year: 2012
    ..fraction of the world population and attack most of the joints in the body, including large joints such as the knee, hip, or shoulder...
  27. Phase-contrast enhanced X-ray imaging system for small joints of hand
    Thomas J Beck; Fiscal Year: 2010
    ..that DPC can image with high resolution soft tissues such as cartilage and ligaments in the joints of the hand, knee and ankle...
  28. Motivational Interviewing and Physical Activity Behavior Change in Arthritis
    Linda Ehrlich-Jones; Fiscal Year: 2012
    ..intervention focuses on increasing lifestyle physical activity in persons with rheumatoid arthritis (RA) and knee osteoarthritis (OA)...
  29. Collider Bias and the Risk Factor Paradoxes in Rheumatic Disease Research
    UYEN SA DUC TRAN NGUYEN; Fiscal Year: 2013
    ..applicant): Rheumatic conditions and their sequelae, including rheumatoid arthritis (RA), psoriatic arthritis, and knee osteoarthritis (OA), constitute a tremendous disease burden in the US and worldwide...
  30. Discontinuing NSAIDs in Veterans with Knee Osteoarthritis
    Liana Fraenkel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Knee osteoarthritis (OA) is a major cause of disability among Veterans and is the primary indication of knee replacement in the VA...
  31. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2013
    ..To test possible postnatal roles of Erg, we subjected 2 month-old Erg-deficient mice to knee's medial collateral ligament (MCL) transection to induce experimental osteoarthritis (OA)...
  32. 2012 AAOS Femoroacetabular Impingement Research Symposium
    John C Clohisy; Fiscal Year: 2011
    ..Lower extremity OA is particularly common and costly. Estimates show that by 2030, over 4.4 million hip and knee replacement procedures will be performed annually in the United States with the number of hip replacements ..
  33. Novel Early Intervention to Prevent Post-Traumatic Osteoarthritis
    Dominik R Haudenschild; Fiscal Year: 2013
    ..A single non-invasive mechanical load applied to the knee induces ACL rupture...
  34. Common mechanisms of Osteoarthritis in three mouse models
    Robert E Seegmiller; Fiscal Year: 2010
    ..of mutations and have different skeletal phenotypes, all three mutants exhibit similar early-onset degeneration of knee-joint cartilage...
  35. Sex Differences in Musculoskeletal Conditions across the Lifespan
    Nancy E Lane; Fiscal Year: 2013
    ..in bone shape and the influence of bone shape on the development, severity and prognosis of osteoarthritis of the knee, and 4) a randomized clinical trial of sex differences in response to an exercise intervention for the treatment of ..
  36. Musculoskeletal Biomechanics of Gradient Walking in Obese Adults
    RAYMOND CLIFTON BROWNING; Fiscal Year: 2012
    ..g. knee) osteoarthritis (OA)...
  37. BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS
    Janis J Weis; Fiscal Year: 2013
    ..inflammatory cell infiltration, synovial hyperplasia, and reactive/reparative changes in joint tissue, with the knee frequently involved. Most individuals respond to antibiotic therapy, eventually resolving symptoms of arthritis...
  38. Biological Markers of System Burden in Symptomatic Knee OA: A Prospective Study
    KIMBERLY THERESA SIBILLE; Fiscal Year: 2013
    ..and experience to pursue investigations of the biological interface of chronic pain and psychosocial stress in knee OA...
  39. Patient-Specific Modeling of Total Knee Arthroplasty
    ROBERT ANTHONY SISTON; Fiscal Year: 2012
    ..The purpose of this work is to develop and validate a process for creating patient-specific simulations of total knee arthroplasty (TKA) with measurements of component alignment and initial soft tissue balance taken at the time of ..
  40. Use Of Adipose Derived Stem Cells For Engineering Of Ligament Tissue
    David McAllister; Fiscal Year: 2012
    Abstract: Rupture of the anterior cruciate ligament (ACL) is one of most common ligament injuries of the knee and is often seen in the VA patient population...
  41. Muscle Afferent Feedback Effects in Patients with Heart Failure
    Markus Amann; Fiscal Year: 2013
    ..rate, blood pressure and ventilation during large and small muscle mass rhythmic exercise (bicycle and single leg knee-extension), and the development of central and peripheral fatigue (using magnetic femoral nerve stimulation ..
  42. Epidemiology of Patellofemoral Pain Syndrome: Identifying Gender Specific Risk Fa
    MICHELLE CLARA BOLING; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Patellofemoral pain syndrome (PFP) is one of the most common causes of knee pain, affecting approximately 25% of the physically active population, with females being 2-3 times more likely to develop ..
  43. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2009
    ..miR-140 null mice showed a phenotype in skeletal framework and also earlier onset of osteoarthritic changes in knee joint at 6 months...
  44. Mandibular Cartilage Regeneration In Situ by Endogenous Stem Cell Recruitment
    Wendy S Vanden Berg-Foels; Fiscal Year: 2013
    ..chemotaxis and FGF-2 induces proliferation by synovial cells in vitro;and 3) growth factor delivery in rabbit knee osteochondral defects induced regeneration of immature hyaline cartilage...
  45. Effect of Intense Multi-Modal Training on Bone Mineral Density, Bone Biomarkers,
    Todd Anthony Astorino; Fiscal Year: 2013
    ..valid index of bone strength and fracture risk, will be assessed at four sites (spine, total body, hip, and knee) at baseline and at three and six months of the program...
  46. JointADventure: A Worksite Activity-Diet Intervention for Chronic Knee Pain
    Rowland W Chang; Fiscal Year: 2013
    ..disability and its associated costs will significantly worsen, largely due to the consequences of knee osteoarthritis (OA)...
  47. Noninvasive Measurement Of Strain And Mechanical Properties In Tendons/Ligaments
    Ray Vanderby; Fiscal Year: 2010
    ..In the U.S. more than 12 million people visited orthopedic surgeons in 2003 because of either knee or shoulder problems...
  48. ESE 1 a novel transcriptional regulator of cartilage remodeling
    MARY GOLDRING; Fiscal Year: 2009
    ..In Specific Aim 3 we will: Determine the effects of ESE-1 overexpression on onset and progression of OA in mouse knee joints due to aging and surgical OA...
  49. Biomechanics and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2012
    ..to reduce the pain, disability, and psychological distress experienced by overweight patients with persistent OA knee pain...
  50. Serum microRNAs as biomarkers of post-traumatic osteoarthritis
    Gary J Gibson; Fiscal Year: 2010
    ..The course of PTOA progression after knee trauma is expected to have substantial overlap with disease progression in general OA...
  51. National Estimates for Inpatient Care, Outcomes &Hospital Effect among Hispanics
    Amresh D Hanchate; Fiscal Year: 2013
    ..g., percutaneous Tran's luminal coronary angioplasty [PTCA] and knee replacement)...
  52. Muscle Weakness and Post-Traumatic Knee OA
    Terese L Chmielewski; Fiscal Year: 2011
    ..to maximize functional outcome and reduce the risk for post-traumatic osteoarthritis (OA) in persons with knee injury...
  53. Identification of Responders to the FES Interventions in Stroke Population
    Rakesh Pilkar; Fiscal Year: 2013
    ..we will determine the 'gait symmetry'of FES assisted walking using bilateral cyclograms of the ankle and knee over a period of 6 months...
  54. ESE 1 a novel transcriptional regulator of cartilage remodeling
    Mary B Goldring; Fiscal Year: 2013
    ..3) Does ESE-1 over-expression affect the onset or progression of OA in mouse knee joints due to aging or surgical OA? We will generate Tet-Off-inducible Ese1 transgenic mice to examine whether ..
  55. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2013
    ..miR-140 null mice showed earlier onset of osteoarthritic changes in knee joint at 6 months...
  56. PHASE-BASED CONTROL OF LOCOMOTION FOR HIGH-PERFORMANCE PROSTHESES AND ORTHOSES
    Robert D Gregg; Fiscal Year: 2013
    ..I will then implement a novel control strategy using this sense of phase on a powered knee-ankle prosthesis, which will be validated with human amputee subjects...
  57. Selection of Therapeutic Agents for Articular Cartilage Repair
    Stephen B Trippel; Fiscal Year: 2013
    ..It has been estimated that, for knee joints alone, there will be an 85% in joint replacements by 2030 due to the lack of efficacy of current treatments (..
  58. Intrinsic Repair of the Knee Meniscus
    Farshid Guilak; Fiscal Year: 2011
    ..applicant): The menisci are intra-articular fibrocartilaginous structures essential to the normal function of the knee joint...
  59. The Role of Alzheimer's-associated Abeta in POD and POCD
    Zhongcong Xie; Fiscal Year: 2012
    ..association of pre-operative CSF A2 and IL-6 levels with POD measured 1, 2 and 3 days after scheduled total hip and knee replacement surgery conducted under spinal anesthesia, the CSF will be collected when spinal anesthesia is ..
  60. Promoting Physical Activity in Older Adults with Comorbidity
    ELIZABETH ANN SCHLENK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Over 9 million Americans have symptomatic osteoarthritis (OA) of the knee, a chronic disease associated with frequent joint pain, functional limitations, and quadriceps weakness that intrude upon ..
  61. Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) Trial
    ERIN ELIZABETH KREBS; Fiscal Year: 2013
    ..n=138) or the opioid-avoidant (n=138) arm, with stratification by primary pain location (back or hip/knee)...
  62. Exercise training and cognitive and physical function in CKD
    Daniel E Weiner; Fiscal Year: 2013
    ..Aerobic capacity (peak V02);3) Physical performance including sub maximal walking speed, timed get up and go test, knee extensor strength, and short physical performance battery;4) HRQoL (Short Form-36);5) Microvascular function using ..
  63. Biologic scaffold prostheses to enhance meniscus repair
    JOE WEINBERG; Fiscal Year: 2009
    Abstract Menisci play critical roles in stabilization and load transmission in the knee joint...
  64. Adaptive High Intensity Electrical Stimulation for Post-Surgical Rehabilitation
    Eric Hartman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Recovery of quadriceps muscle force following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily ..
  65. Ethnicity, Gender & Social Support in Knee Osteoarthritis
    HUAN CHANG; Fiscal Year: 2007
    ..She will continue to submit grant applications to support these ideas. In patients with severe knee osteoarthritis (CA), total knee replacement (TKR) relieves chronic pain, restores lost function, and is cost- ..
  66. ActiveImplant Prosthesis for Lower Limb Amputees
    JOHN FAGO; Fiscal Year: 2007
    ..the feasibility and potential for an implantable prosthetic device at the distal end of the cut bone for above-knee (AK) amputees...
  67. KNEE STABILITY TRAINING IN INDIVDUALS WITH KNEE OSTEOARTHRITIS
    G Fitzgerald; Fiscal Year: 2007
    Traditional exercise therapy programs for knee osteoarthritis (OA) primarily focus on addressing lower extremity strength and joint motion deficits and have yielded fair to moderate improvements in functional status...
  68. HUMAN RESPONSE AND LOWER EXTREMITY INJURY
    CLAYTON MOTE; Fiscal Year: 1991
    The mechanics of injury to the human knee is a complex process where external forces are transmitted to the lower extremity, the lower extremity responds causing displacements and rotations across the knee, stresses are induced in the ..
  69. The Effect of Exercise on Progression of Knee OA
    ANDREW CONCOFF; Fiscal Year: 2003
    ..with the conduction of an arthroscopically-based trial of the effect of exercise on the progression of knee OA...
  70. Osteopuncture for OA-Associated Knee Pain & Disability
    Debra Weiner; Fiscal Year: 2005
    DESCRIPTION(provided by applicant): Chronic knee pain associated with osteoarthritis (OA) is a leading cause of physical disability and health care resource utilization for older Americans...
  71. Relation of Alignment and Other Risk Factors to Knee OA
    DAVID TOBIN FELSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Symptomatic knee osteoarthritis affects 6% of the U.S. adult population and 12-13% of those age 60 and over (Felson and Zhang, 1998)...
  72. Pain Assessment in Elders with Osteoarthritis
    Pao Feng Tsai; Fiscal Year: 2004
    b>Knee and hip osteoarthritis (OA) are highly prevalent (16.6%-33% for the knee and 10.4%-26.3% for the hip) and the leading causes of disability in elders. Activity instigates and aggravates pain in patients with severe knee or hip OA...
  73. Enabling ACL Repair Using Proprietary Collagen Device
    Emma Wright; Fiscal Year: 2009
    ..evaluation for development of osteoarthritis (OA), validated gait/lameness scores, arthroscopic inspection of the knee, comparison of biomechanical results and histology to known standards, and has the potential to control ..
  74. Powered Knee Prosthesis Incorporating Battery-Capacitor Hybrid
    BADAWI M DWEIK; Fiscal Year: 2012
    ..The latest commercial product is a prosthetic knee powered by an electric motor designed to function as an integrated extension of its user...
  75. BONE AND KNEE LOADING
    Hiroki Yokota; Fiscal Year: 2005
    ..In this project, we propose to investigate a novel mechanical loading model- knee joint loading - to stimulate bone formation and to strengthen mechanical properties of femur and a femoral neck...
  76. Aerobic Exercise Intervention for Knee Osteoarthritis
    Kenton Kaufman; Fiscal Year: 2005
    ..Exercise as an adjunct therapy in the clinical management of patients with osteoarthritis of the knee, however, is not uniformly accepted...
  77. EVALUATOR TRAINING MANIKIN FOR SPASTICITY AND STRENGTH
    DAVID ENGSBERG; Fiscal Year: 2003
    ..The purpose of this project is to develop and test a manikin knee joint for training clinicians to uniformly assess knee spasticity and strength. Aim 1...
  78. TIDAL LAVAGE VS SHAM LAVAGE IN KNEE OSTEOARTHRITIS
    John Bradley; Fiscal Year: 1999
    ..TL is being used increasingly to treat knee OA...