Summary: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE), METATARSUS, phalanges, and the soft tissues surrounding these bones.

Top Publications

  1. ncbi The condition for dynamic stability
    A L Hof
    Institute of Human Movement Sciences, University of Groningen, University Hospital, PO Box 196, AD Groningen 9700, The Netherlands
    J Biomech 38:1-8. 2005
  2. doi Cortical network dynamics during foot movements
    Fabrizio de Vico Fallani
    Interdep Research Centre for Models and Information Analysis in Biomedical Systems, University of Rome Sapienza, Corso V Emanuele, 244, 00186 Rome, Italy
    Neuroinformatics 6:23-34. 2008
  3. doi The foot: still the most important reason for walking incapacity in rheumatoid arthritis: distribution of symptomatic joints in 1,000 RA patients
    Lollo Grondal
    Department of Molecular Medicine and Surgery, Orthopedic Rehabilitation, Karolinska Institute, Red Cross Hospital, Stockholm, Sweden
    Acta Orthop 79:257-61. 2008
  4. ncbi Control of foot trajectory in human locomotion: role of ground contact forces in simulated reduced gravity
    Y P Ivanenko
    Sezione di Fisiologia Umana, Istituto Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
    J Neurophysiol 87:3070-89. 2002
  5. ncbi An improved powered ankle-foot orthosis using proportional myoelectric control
    Daniel P Ferris
    Department of Movement Science, University of Michigan, Ann Arbor, MI 48109 2214, USA
    Gait Posture 23:425-8. 2006
  6. pmc A cognitive-motor intervention using a dance video game to enhance foot placement accuracy and gait under dual task conditions in older adults: a randomized controlled trial
    Giuseppe Pichierri
    Department Health Sciences and Technology D HEST, Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland
    BMC Geriatr 12:74. 2012
  7. doi Foot and ankle strength, range of motion, posture, and deformity are associated with balance and functional ability in older adults
    Martin J Spink
    Musculoskeletal Research Centre, Department of Podiatry, La Trobe University, Bundoora, Australia
    Arch Phys Med Rehabil 92:68-75. 2011
  8. pmc The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis
    Eric C Sayre
    Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada
    PLoS ONE 5:e10470. 2010
  9. pmc The impact of rheumatoid arthritis on foot function in the early stages of disease: a clinical case series
    Deborah E Turner
    Department of Podiatry, University of Huddersfield, Huddersfield, UK
    BMC Musculoskelet Disord 7:102. 2006
  10. doi Long-term therapeutic and orthotic effects of a foot drop stimulator on walking performance in progressive and nonprogressive neurological disorders
    Richard B Stein
    University of Alberta, Edmonton, Alberta, Canada
    Neurorehabil Neural Repair 24:152-67. 2010

Detail Information

Publications402 found, 100 shown here

  1. ncbi The condition for dynamic stability
    A L Hof
    Institute of Human Movement Sciences, University of Groningen, University Hospital, PO Box 196, AD Groningen 9700, The Netherlands
    J Biomech 38:1-8. 2005
    ..Some experimental data of subjects standing on one or two feet, flatfoot and tiptoe, are presented to give an idea of the usual ranges of these margins of stability. Example data on walking are also presented...
  2. doi Cortical network dynamics during foot movements
    Fabrizio de Vico Fallani
    Interdep Research Centre for Models and Information Analysis in Biomedical Systems, University of Rome Sapienza, Corso V Emanuele, 244, 00186 Rome, Italy
    Neuroinformatics 6:23-34. 2008 intends to evaluate the dynamics of the cerebral networks during the preparation and the execution of the foot movement...
  3. doi The foot: still the most important reason for walking incapacity in rheumatoid arthritis: distribution of symptomatic joints in 1,000 RA patients
    Lollo Grondal
    Department of Molecular Medicine and Surgery, Orthopedic Rehabilitation, Karolinska Institute, Red Cross Hospital, Stockholm, Sweden
    Acta Orthop 79:257-61. 2008
    Our knowledge of frequency of foot involvement in rheumatoid arthritis (RA) is still often based on a study from Finland in 1956. Great changes in the treatment of RA may have led to a different situation...
  4. ncbi Control of foot trajectory in human locomotion: role of ground contact forces in simulated reduced gravity
    Y P Ivanenko
    Sezione di Fisiologia Umana, Istituto Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
    J Neurophysiol 87:3070-89. 2002
    ..By contrast, the corresponding variation of the parameters that describe shape and variability of the foot path was very limited, always <30% of the corresponding values at 0 BWS...
  5. ncbi An improved powered ankle-foot orthosis using proportional myoelectric control
    Daniel P Ferris
    Department of Movement Science, University of Michigan, Ann Arbor, MI 48109 2214, USA
    Gait Posture 23:425-8. 2006
    We constructed a powered ankle-foot orthosis for human walking with a novel myoelectric controller. The orthosis included a carbon fiber and polypropylene shell, a metal hinge joint, and two artificial pneumatic muscles...
  6. pmc A cognitive-motor intervention using a dance video game to enhance foot placement accuracy and gait under dual task conditions in older adults: a randomized controlled trial
    Giuseppe Pichierri
    Department Health Sciences and Technology D HEST, Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland
    BMC Geriatr 12:74. 2012
    ..The aim is to investigate the different effects of the training programs on physical and psychological parameters in older adults...
  7. doi Foot and ankle strength, range of motion, posture, and deformity are associated with balance and functional ability in older adults
    Martin J Spink
    Musculoskeletal Research Centre, Department of Podiatry, La Trobe University, Bundoora, Australia
    Arch Phys Med Rehabil 92:68-75. 2011
    To determine the extent to which measures of foot and ankle strength, range of motion, posture, and deformity are associated with performance in a battery of balance and functional ability tests in older adults.
  8. pmc The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis
    Eric C Sayre
    Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada
    PLoS ONE 5:e10470. 2010
    Osteoarthritis (OA) has a significant impact on individuals' ability to work. Our goal was to investigate the effects of the site of OA (knee, hip, hand, foot, lower back or neck) on employment reduction due to OA (EROA).
  9. pmc The impact of rheumatoid arthritis on foot function in the early stages of disease: a clinical case series
    Deborah E Turner
    Department of Podiatry, University of Huddersfield, Huddersfield, UK
    BMC Musculoskelet Disord 7:102. 2006
    b>Foot involvement occurs early in rheumatoid arthritis but the extent to which this impacts on the structure and function leading to impairment and foot related disability is unknown...
  10. doi Long-term therapeutic and orthotic effects of a foot drop stimulator on walking performance in progressive and nonprogressive neurological disorders
    Richard B Stein
    University of Alberta, Edmonton, Alberta, Canada
    Neurorehabil Neural Repair 24:152-67. 2010
    Stimulators applying functional electrical stimulation (FES) to the common peroneal nerve improve walking with a foot drop, which occurs in several disorders.
  11. doi Does functional electrical stimulation for foot drop strengthen corticospinal connections?
    Dirk G Everaert
    University of Alberta, Edmonton, Alberta, Canada
    Neurorehabil Neural Repair 24:168-77. 2010
    Long-term use of a foot-drop stimulator applying functional electrical stimulation (FES) to the common peroneal nerve improves walking performance even when the stimulator is off...
  12. pmc Measuring newborn foot length to identify small babies in need of extra care: a cross sectional hospital based study with community follow-up in Tanzania
    Tanya Marchant
    Department of Global Health and Development, LSHTM, 15 17 Tavistock Place, London, UK
    BMC Public Health 10:624. 2010
    ..aimed to estimate the sensitivity and specificity, and the positive and negative predictive values of newborn foot length to identify babies who are low birth weight or premature and in need of extra care in a rural African setting...
  13. doi Quantitative estimation of foot-flat and stance phase of gait using foot-worn inertial sensors
    Benoit Mariani
    Laboratory of Movement Analysis and Measurements, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Gait Posture 37:229-34. 2013
    ..This study aimed, first, to describe a novel method for detecting stance and inner-stance temporal events based on foot-worn inertial sensors; second, to extract and validate relevant metrics from those events; and third, to ..
  14. pmc Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection
    Egidio Torrado
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
    Infect Immun 75:3979-88. 2007
    ..ulcerans bacilli inhibits, in a dose-dependent manner, but does not abrogate, the production of macrophage inflammatory protein 2, which is consistent with the persistent inflammatory responses observed in experimentally infected mice...
  15. ncbi The role of limited joint mobility in diabetic patients with an at-risk foot
    Stefan Zimny
    Evangelisches Krankenhaus Bethesda, Akademisches Lehrkrankenhaus der Universität Düsseldorf, Medizinische Klinik I, Duisburg, Germany
    Diabetes Care 27:942-6. 2004
    To assess the role of limited joint mobility (LJM) in causing abnormal high plantar pressures in the forefoot of diabetic patients with an at-risk foot.
  16. doi Inertial Gait Phase Detection for control of a drop foot stimulator Inertial sensing for gait phase detection
    D Kotiadis
    Biomedical Signals and Systems Group, University of Twente, Enschede, The Netherlands
    Med Eng Phys 32:287-97. 2010
    ..system was developed to replace heel switches and footswitches currently being used for the triggering of drop foot stimulators...
  17. ncbi Modular organization of human leg withdrawal reflexes elicited by electrical stimulation of the foot sole
    O K Andersen
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7, D3, DK 9220, Aalborg, Denmark
    Muscle Nerve 22:1520-30. 1999
    ..fields were determined for leg muscles by randomized, electrical stimulation at 16 different positions on the foot sole...
  18. ncbi The measurement of the medial longitudinal arch in children
    J C Gilmour
    Department of Pediatrics, Mater Children s Hospital, South Brisbane, Australia
    Foot Ankle Int 22:493-8. 2001
    ..The NH changed with age, suggesting it provides a useful, easily obtained clinical measure. The Al measures were slightly more reliable than the NH but showed less change with age...
  19. doi On the origin of planar covariation of elevation angles during human locomotion
    Y P Ivanenko
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 306 via Ardeatina, 00179 Rome, Italy
    J Neurophysiol 99:1890-8. 2008
    ..Recent advances in the neural control of movement support the hypothesis about central representation of kinematics components...
  20. doi A comparison of foot kinematics in people with normal- and flat-arched feet using the Oxford Foot Model
    Pazit Levinger
    Musculoskeletal Research Centre, Faculty of Health Sciences, La Trobe University, Bundoora 3086, Vic, Australia
    Gait Posture 32:519-23. 2010
    b>Foot posture is thought to influence predisposition to overuse injuries of the lower limb. Although the mechanisms underlying this proposed relationship are unclear, it is thought that altered foot kinematics may play a role...
  21. pmc Indoor pedestrian navigation using foot-mounted IMU and portable ultrasound range sensors
    Gabriel Girard
    Department of Computer Science, Universite de Sherbrooke, 2500 Boulevard de l Universite, Sherbrooke J1K 2R1, QC, Canada
    Sensors (Basel) 11:7606-24. 2011
    ..The system uses a combination of four techniques: foot-mounted IMU (Inertial Motion Unit), ultrasonic ranging, particle filtering and model-based navigation...
  22. ncbi "Central command" and insular activation during attempted foot lifting in paraplegic humans
    Markus Nowak
    The Copenhagen Muscle Research Center, Rigshospitalet, Copenhagen, Denmark
    Hum Brain Mapp 25:259-65. 2005
    The relationship between cardiovascular regulation and brain activation was investigated during attempted foot lifting in paraplegic subjects and during rhythmic handgrip exercise at one-third of maximum voluntary contraction force...
  23. ncbi Foot type classification: a critical review of current methods
    Mohsen Razeghi
    Centre for Sports Medicine, Division of Orthopaedic and Accident Surgery, C Floor, West Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Gait Posture 15:282-91. 2002
    Investigation into the effects of foot structure on foot function, and the risks of injury, has been at the core of many studies, sometimes with conflicting results...
  24. ncbi Foot-use laterality in the Japanese jungle crow (Corvus macrorhynchos)
    Ei Ichi Izawa
    Department of Psychology, Keio University, Tokyo 108 8345, Japan Japan Society for Promotion of Science, Tokyo 108 8345, Japan
    Behav Processes 69:357-62. 2005
    Laterality of foot-use behaviour was examined in jungle crows (Corvus macrorhynchos). Consistency of laterality was also verified in comparison with two different behaviours. One was beak-scratching, and another was food-holding...
  25. doi The impact of hallux valgus on foot kinematics: a cross-sectional, comparative study
    Kevin Deschamps
    Division of Musculoskeletal Disorders, University Hospitals Leuven, KU Leuven, Belgium
    Gait Posture 32:102-6. 2010
    Hallux valgus is a very common foot deformity in modern societies. The impact of this condition on foot function has been described qualitatively and quantitatively...
  26. ncbi Reliability and validity of bilateral thigh and foot accelerometry measures of walking in healthy and hemiparetic subjects
    Kaveh Saremi
    Neurologic Rehabilitation and Research Program, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 20:297-305. 2006
    ..A new integrated system of 5 accelerometers was tested for reliability and compared to a footswitch system to determine if the accelerometers offered a practical option for the acquisition of spatiotemporal gait parameters...
  27. ncbi Ultrasound detection of entheseal insertions in the foot of patients with spondyloarthropathy
    Pinar Borman
    Clinic of Physical Medicine and Rehabilitation, Numune Training and Research Hospital, II Samanpazari, 06100 Ankara, Turkey
    Clin Rheumatol 25:373-7. 2006
    The aim of the study was to evaluate entheseal involvement in the foot of patients with spondyloarthropathy (SpA) by ultrasonographic (US) examination and compare the results with clinical and radiological findings...
  28. ncbi Functional magnetic resonance imaging detects activation of the visual association cortex during laser acupuncture of the foot in humans
    Christian M Siedentopf
    Department of Radiology II, University Hospital of Innsbruck, Innsbruck, Austria
    Neurosci Lett 327:53-6. 2002
    ..Using functional magnetic imaging (fMRI) cortical activations during laser acupuncture at the left foot (Bladder 67) and dummy acupuncture, were compared employing a block design in ten healthy male volunteers...
  29. doi Powered ankle-foot prosthesis to assist level-ground and stair-descent gaits
    Samuel Au
    MIT Media Laboratory, 20 Ames Street, Cambridge, MA 02139, USA
    Neural Netw 21:654-66. 2008
    ..In contrast, commercially available ankle-foot prostheses are passive during stance, causing many clinical problems for transtibial amputees, including non-..
  30. doi Features of hand-foot crawling behavior in human adults
    M J Maclellan
    Laboratory of Neuromotor Physiology, IRCCS Fondazione Santa Lucia, 306 via Ardeatina, 00179 Rome, Italy
    J Neurophysiol 107:114-25. 2012
    ..The findings highlight the reorganization and adaptation of CPG networks involved in the control of quadrupedal human locomotion and a high specialization of the musculoskeletal apparatus to specific gaits...
  31. doi Ambulatory estimation of foot placement during walking using inertial sensors
    H Martin Schepers
    Institute for Biomedical Technology and Technical Medicine MIRA, University of Twente, AE Enschede, The Netherlands
    J Biomech 43:3138-43. 2010
    This study proposes a method to assess foot placement during walking using an ambulatory measurement system consisting of orthopaedic sandals equipped with force/moment sensors and inertial sensors (accelerometers and gyroscopes)...
  32. ncbi Preventive foot care in people with diabetes
    J A Mayfield
    Bowen Research Center, Department of Family Medicine, Indiana University, Indianapolis 46202, USA
    Diabetes Care 21:2161-77. 1998
    A number of effective, low-cost strategies are available to identify and treat the person at risk for diabetic foot ulcers and lower-extremity amputation...
  33. doi Coding observed motor acts: different organizational principles in the parietal and premotor cortex of humans
    Jan Jastorff
    Laboratorium voor Neuro en Psychophysiologie, Medical School, K U Leuven, Leuven, Belgium
    J Neurophysiol 104:128-40. 2010
    ..showing four different motor acts (dragging, dropping, grasping, and pushing) performed with different effectors (foot, hand, and mouth). We found that the coding of observed motor acts differed between premotor and parietal cortex...
  34. ncbi Footprint and radiographic analysis of the feet
    U Kanatli
    Gazi University Medical Faculty, Orthopaedics and Traumatology Department, Besevler, Ankara, Turkey
    J Pediatr Orthop 21:225-8. 2001
    There is controversy concerning the definition and measurement of the medial longitudinal arch of the foot. Various techniques are reported to assess the medial arch height, including radiographic measurements and footprint analysis, ..
  35. ncbi Subtalar joint axis location and rotational equilibrium theory of foot function
    K A Kirby
    Department of Podiatric Biomechanics, California College of Podiatric Medicine, San Francisco, CA, USA
    J Am Podiatr Med Assoc 91:465-87. 2001
    A new theory of foot function based on the spatial location of the subtalar joint axis in relation to the weightbearing structures of the plantar foot is proposed...
  36. doi The prevalence of hallux valgus and its association with foot pain and function in a rural Korean community
    N H Cho
    Department of Preventive Medicine, Ajou University School of Medicine, 5 Wonchon dong, Youngtong Gu, Suwon 442 749, Korea
    J Bone Joint Surg Br 91:494-8. 2009
    ..A total of 563 subjects was examined using the foot health status questionnaire, the Short Form-36 questionnaire and weight-bearing anteroposterior radiographs...
  37. doi Control of a powered ankle-foot prosthesis based on a neuromuscular model
    Michael F Eilenberg
    Mechanical Engineering Department, Massachusetts Institute of Technology MIT, Cambridge, MA, USA
    IEEE Trans Neural Syst Rehabil Eng 18:164-73. 2010
    Control schemes for powered ankle-foot prostheses rely upon fixed torque-ankle state relationships obtained from measurements of intact humans walking at target speeds and across known terrains...
  38. doi Foot strike patterns and collision forces in habitually barefoot versus shod runners
    Daniel E Lieberman
    Department of Human Evolutionary Biology, 11 Divinity Avenue, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 463:531-5. 2010
    ..We wondered how runners coped with the impact caused by the foot colliding with the ground before the invention of the modern shoe...
  39. doi Characterising the clinical and biomechanical features of severely deformed feet in rheumatoid arthritis
    Deborah E Turner
    School of Health and Social Care and HealthQWest, Glasgow Caledonian University, Glasgow, UK
    Gait Posture 28:574-80. 2008
    b>Foot deformity is a well-recognised impairment in patients with rheumatoid arthritis (RA) which results in functional disability...
  40. ncbi The influence of hands posture on mental rotation of hands and feet
    Silvio Ionta
    Department of Clinical Sciences and Bioimaging, Institute of Advanced Biomedical Technologies, University of Chieti Pescara G D Annunzio, Via dei Vestini 33, 66013, Chieti Scalo, Italy
    Exp Brain Res 183:1-7. 2007
    ..Thus, sensory-motor and postural information coming from the body may influence mental rotation of body parts according to specific, somatotopic rules...
  41. ncbi The morphological basis of hallucal orientation in extant birds
    K M Middleton
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    J Morphol 250:51-60. 2001
    The perching foot of living birds is commonly characterized by a reversed or opposable digit I (hallux). Primitively, the hallux of nonavian theropod dinosaurs was unreversed and lay parallel to digits II-IV...
  42. ncbi Intrinsic pedal musculature support of the medial longitudinal arch: an electromyography study
    Paul Fiolkowski
    Gemini Research Consulting, Gainsville, FL 32606, USA
    J Foot Ankle Surg 42:327-33. 2003
    ..The height of the navicular tubercle above the floor was measured in both feet while subjects were seated with the foot in a subtalar neutral position and then when standing in a relaxed calcaneal stance...
  43. ncbi Infectious and healing complications after elective orthopaedic foot and ankle surgery during tumor necrosis factor-alpha inhibition therapy
    Christopher Bibbo
    Department of Orthopaedic Surgery, Marshfield Clinic, WI 54449, USA
    Foot Ankle Int 25:331-5. 2004
    ..This study analyzed the risk of healing/infectious complications in patients undergoing elective foot and ankle surgery while being treated with TNF-alpha inhibitors etanercept and infliximab.
  44. pmc Bactericidal activity of rifampin-amikacin against Mycobacterium ulcerans in mice
    Herve Dega
    Faculté de Médecine Pitié Salpêtrière, Service de Bacteriologie et Hygiene, 75634 Paris Cedex 13, France
    Antimicrob Agents Chemother 46:3193-6. 2002
    ..The promising results of RIF-AMK treatment in M. ulcerans-infected mice support the clinical trial that is currently in progress under World Health Organization auspices in Ghana...
  45. ncbi Foot deformities in rheumatoid arthritis and relevance of foot function index
    Ajda Bal
    Physical Medicine and Rehabilitation Clinic, Health Ministry Dişkapi Educational and Research Hospital, Ankara, Turkey
    Clin Rheumatol 25:671-5. 2006
    The aim of this study were to assess what type of foot deformities are found in rheumatoid arthritis (RA) patients, to detect frequency of deformities, and to evaluate deformities affecting Foot Function Index (FFI) and patient functional ..
  46. ncbi Fatigue of the plantar intrinsic foot muscles increases navicular drop
    Donella L Headlee
    University of Virginia Exercise and Sports Injury Laboratory P O Box 400407, Charlottesville, VA 22904 4407, United States
    J Electromyogr Kinesiol 18:420-5. 2008
    Our purpose was to assess the effect of foot intrinsic muscle fatigue on pronation, as assessed with navicular drop, during static stance. Twenty-one healthy young adults participated...
  47. ncbi Foot kinematics during walking measured using bone and surface mounted markers
    C Nester
    Centre for Rehabilitation and Human Performance Research, Brian Blatchford Building, University of Salford, M66PU, UK
    J Biomech 40:3412-23. 2007
    The aim was to compare kinematic data from an experimental foot model comprising four segments ((i) heel, (ii) navicular/cuboid (iii) medial forefoot, (iv) lateral forefoot), to the kinematics of the individual bones comprising each ..
  48. ncbi Amputation as a marker of the quality of foot care in diabetes
    W J Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham, NG5 1PB, UK
    Diabetologia 47:2051-8. 2004
    Strategic targets for the management of foot ulcers focus on reducing the incidence of amputation. While data on the incidence of amputation can be obtained relatively easily, the figures require very careful interpretation...
  49. ncbi The foot function index with verbal rating scales (FFI-5pt): A clinimetric evaluation and comparison with the original FFI
    Marijke M Kuyvenhoven
    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, The Netherlands
    J Rheumatol 29:1023-8. 2002
    To assess the clinimetric value of the Dutch version of the Foot Function Index (FFI) in comparison with the original FFI using verbal rating scales (FFI-5pt) rather than visual analog scales (VAS).
  50. ncbi Minimum foot clearance during walking: strategies for the minimisation of trip-related falls
    Rezaul Begg
    Biomechanics Unit, Centre for Ageing, Rehabilitation, Exercise and Sport, Victoria University, City Flinders Campus, PO Box 14428, MCMC, Melbourne, VIC 8001, Australia
    Gait Posture 25:191-8. 2007
    This paper models minimum foot clearance (MFC) data during steady-state gait to investigate how the various descriptive statistics of the MFC distribution differ in healthy young and elderly females...
  51. doi The role of 99mTc-diphosphonate bone SPECT/CT in the ankle and foot
    Malavika Nathan
    Department of Nuclear Medicine, Royal Free London NHS Foundation Trust, London, UK
    Nucl Med Commun 33:799-807. 2012
    The evaluation of the osseous ankle and foot pathology often poses a clinical and diagnostic challenge because of the complex anatomy and structural biomechanics of the region...
  52. ncbi Foot odor due to microbial metabolism and its control
    Katsutoshi Ara
    Biological Science Laboratories, Kao Co, Ltd, Tochigi 321 3497, Japan
    Can J Microbiol 52:357-64. 2006
    To characterize foot odor, we analyzed its components by sensory tests, isolated microorganisms that produce it, and evaluated the mechanism of the occurrence of foot odor...
  53. pmc A booster vaccination with Mycobacterium bovis BCG does not increase the protective effect of the vaccine against experimental Mycobacterium ulcerans infection in mice
    Audrey Tanghe
    Mycobacterial Immunology, WIV Pasteur Institute Brussels, 642 Engelandstraat, B 1180 Brussels, Belgium
    Infect Immun 75:2642-4. 2007
    ..M. bovis BCG vaccine offers only short-term protection against experimental footpad infection of C57BL/6 mice with M. ulcerans, and the duration of this protection cannot be prolonged by a booster vaccination...
  54. ncbi Modulation of lower limb withdrawal reflexes during gait: a topographical study
    Erika G Spaich
    Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7 D3, DK 9220 Aalborg, Denmark
    J Neurophysiol 91:258-66. 2004
    ..modulation and topography of the nociceptive withdrawal reflex elicited by painful electrical stimulation of the foot sole during gait. Fifteen healthy volunteers participated in this study...
  55. ncbi Reliability of the Foot Function Index:: A report of the AOFAS Outcomes Committee
    Julie Agel
    University of Washington, Orthopaedics, 325 Ninth Avenue, Seattle, WA 98104, USA
    Foot Ankle Int 26:962-7. 2005
    ..self-administered instrument for measuring musculoskeletal functional status in individuals with nonsystemic foot disorders. The purpose of this paper was to report on the assessment of reliability of one of these instruments...
  56. pmc Ankle dorsiflexion as an fMRI paradigm to assay motor control for walking during rehabilitation
    Bruce H Dobkin
    Department of Neurology, Reed Neurologic Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuroimage 23:370-81. 2004
    ..the thoracolumbar muscle representation of S1M1 in these subjects was followed by more focused activity toward the foot representation with additional pulses of training...
  57. pmc The Charcot foot in diabetes
    Lee C Rogers
    Valley Presbyterian Hospital, Los Angeles, CA, USA
    Diabetes Care 34:2123-9. 2011
    The diabetic Charcot foot syndrome is a serious and potentially limb-threatening lower-extremity complication of diabetes. First described in 1883, this enigmatic condition continues to challenge even the most experienced practitioners...
  58. ncbi Numerical simulation of the plantar pressure distribution in the diabetic foot during the push-off stance
    Ricardo L Actis
    Engineering Software Research and Development, Inc, 111 West Port Plaza, Suite 825, St Louis, MO 63146, USA
    Med Biol Eng Comput 44:653-63. 2006
    The primary objective of conservative care for the diabetic foot is to protect the foot from excessive pressures...
  59. ncbi The role of plantar cutaneous sensation in unperturbed stance
    Peter F Meyer
    Department of Biomedical Engineering, Boston University, MA 02215, USA
    Exp Brain Res 156:505-12. 2004
    ..It remains unclear, however, to what extent specific foot and ankle sensory systems are involved...
  60. ncbi Behavior and body temperature in rats following chronic foot shock or psychological stress exposure
    Y Endo
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health Japan, 1 1 Iseigaoka, Yahatanishi ku, 807 8555, Kitakyushu, Japan
    Physiol Behav 71:263-8. 2000
    ..Male Wistar rats were exposed to foot shock (physical) or non-foot shock stress (psychological) induced by the communication box for 1 h daily over 12 ..
  61. ncbi Reliability and validity of the subjective component of the American Orthopaedic Foot and Ankle Society clinical rating scales
    Talal Ibrahim
    Department of Orthopaedic Surgery, Kettering General Hospital, United Kingdom
    J Foot Ankle Surg 46:65-74. 2007
    This study evaluates the criterion validity of the subjective component of the American Orthopaedic Foot and Ankle Society (AOFAS) clinical rating scales by correlating scores obtained with these rating scales to scores obtained with the ..
  62. doi Stature and gender estimation using foot measurements
    Gulsah Zeybek
    Department of Anatomy, Dokuz Eylul University, Izmir, Turkey
    Forensic Sci Int 181:54.e1-5. 2008
    ..The aim of this study is to develop formulae for estimation of the stature and gender through foot measurements when necessary...
  63. pmc Foot-strike haemolysis after a 60-km ultramarathon
    Giuseppe Lippi
    Unit of Diagnostic Blood Chemistry, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy
    Blood Transfus 10:377-83. 2012
    ..The effective contribution of foot-strike haemolysis is unclear.
  64. ncbi Plantar tissue thickness is related to peak plantar pressure in the high-risk diabetic foot
    F Abouaesha
    Department of Medicine, Manchester Royal Infirmary, University of Manchester, Manchester, UK
    Diabetes Care 24:1270-4. 2001
    To investigate the relationship among plantar foot pressure, plantar subcutaneous tissue thickness, severity of neuropathy (vibration perception threshold [VPT]), callus, and BMI in a large group of neuropathic diabetic patients at risk ..
  65. doi Stature estimation from foot dimensions
    Tanuj Kanchan
    Department of Forensic Medicine and Toxicology, Kasturba Medical College, Light House Hill Road, KMC, Mangalore 575001, Karnataka, India
    Forensic Sci Int 179:241.e1-5. 2008
    Identification of an individual is the mainstay in forensic investigations. The dimensions of the foot have been used for the determination of sex, age, and stature of an individual...
  66. pmc Classifying EEG signals preceding right hand, left hand, tongue, and right foot movements and motor imageries
    Valerie Morash
    Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Clin Neurophysiol 119:2570-8. 2008
    ..To use the neural signals preceding movement and motor imagery to predict which of the four movements/motor imageries is about to occur, and to access this utility for brain-computer interface (BCI) applications...
  67. pmc Patient specific ankle-foot orthoses using rapid prototyping
    Constantinos Mavroidis
    Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA
    J Neuroeng Rehabil 8:1. 2011
    ..A computerized technique for fabricating patient-specific orthotic devices has the potential to provide excellent comfort and allow for changes in the standard design to meet the specific needs of each patient...
  68. doi Timing-specific transfer of adapted muscle activity after walking in an elastic force field
    Andreanne Blanchette
    Center for Interdisciplinary Research in Rehabilitation and Social Integration, Department of Rehabilitation, Univesité Laval, Quebec City, 525 Blvd Wilfrid Hamel, Rm H 1320, Quebec, QC G1M 2S8, Canada
    J Neurophysiol 102:568-77. 2009
    ..on a treadmill before, during, and after exposure to a force field generated by elastic tubing that pulled the foot forward and up during swing...
  69. pmc Foot small muscle atrophy is present before the detection of clinical neuropathy
    Robert L Greenman
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Rd, Boston, MA 02115, USA
    Diabetes Care 28:1425-30. 2005
    To characterize structural changes and the metabolic profile of foot muscles and correlate them with diabetic neuropathy measurements using phosphorus-31 ((31)P) rapid acquisition with relaxation enhancement (RARE) magnetic resonance ..
  70. pmc Three-dimensional measurement of foot arch in preschool children
    Hsun Wen Chang
    Department of Biomedical Engineering, National Cheng Kung University, 1 University Road, Tainan, Taiwan
    Biomed Eng Online 11:76. 2012
    ..To date, a universally accepted evaluation method of the foot arch in children has not been completely established...
  71. doi Test-retest reliability of dynamic plantar loading and foot geometry measures in diabetics with peripheral neuropathy
    J K Gurney
    Department of Sport and Exercise Science, The University of Auckland, New Zealand
    Gait Posture 37:135-7. 2013
    ..Dynamic plantar loading and foot geometry data were collected during barefoot gait with the EMED platform (Novel GmbH, Germany) from 10 patients ..
  72. doi Cross-cultural adaptation and validation of the Foot Function Index for use in German-speaking patients with foot complaints
    Florian D Naal
    Department of Orthopaedic Surgery, Foot and Ankle Center, Schulthess Clinic, Lengghalde 2, 8008 Zurich, Switzerland
    Foot Ankle Int 29:1222-8. 2008
    The purpose of this study was to cross-culturally adapt the Foot Function Index (FFI) for use in German-speaking patients with foot complaints.
  73. pmc Ovine pedomics: the first study of the ovine foot 16S rRNA-based microbiome
    Leo A Calvo-Bado
    Department of Biological Sciences, School of Life Sciences, University of Warwick, Coventry, UK
    ISME J 5:1426-37. 2011
    ..nodosus, which was detected in all samples including the flock with no signs of ID or VFR. Sheep with ID had significantly higher numbers of D. nodosus (10(4)-10(9) cells per g tissue) than those with H or VFR feet...
  74. ncbi MR imaging features of foot involvement in patients with psoriasis
    C Zuhal Erdem
    Department of Radiology, Zonguldak Karaelmas University, School of Medicine, Zonguldak, Turkey
    Eur J Radiol 67:521-5. 2008
    To determine alterations of the soft tissues, tendons, cartilage, joint spaces, and bones of the foot using magnetic resonance (MR) imaging in patients with psoriasis.
  75. doi Gait phase detection and discrimination between walking-jogging activities using hidden Markov models applied to foot motion data from a gyroscope
    Andrea Mannini
    The BioRobotics Institute, Scuola Superiore Sant Anna, Piazza Martiri della Libertà, 33, 56127 Pisa, Italy
    Gait Posture 36:657-61. 2012
    ..The gait events foot strike, foot flat, heel off, toe off were detected using a uni-axial gyroscope that measured the foot instep ..
  76. doi Assessment of lameness in sows using gait, footprints, postural behaviour and foot lesion analysis
    J Gregoire
    Agriculture and Agri Food Canada, Dairy and Swine R and D Centre, Sherbrooke, QC, J1M 0C8 Canada
    Animal 7:1163-73. 2013
    ..gait scoring used as a reference: footprint analysis, kinematics, accelerometers, lying-to-standing transition and foot lesion observation...
  77. ncbi Midfoot amputations expand limb salvage rates for diabetic foot infections
    Patrick A Stone
    Division of Vascular and Endovascular Surgery, University of South Florida, Tampa, FL 33606, USA
    Ann Vasc Surg 19:805-11. 2005
    ..diabetic patients prompted an evaluation of transmetatarsal (TMA) and transtarsal/midfoot amputations in achieving foot salvage at our tertiary vascular practice...
  78. pmc Reliability study of tibialis posterior and selected leg muscle EMG and multi-segment foot kinematics in rheumatoid arthritis associated pes planovalgus
    Ruth Barn
    Institute for Applied Health Research, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom
    Gait Posture 36:567-71. 2012
    ..To determine within- and between-day reliability characteristics of electromyographic (EMG) activity patterns of selected lower leg muscles and kinematic variables in patients with rheumatoid arthritis (RA) and pes planovalgus...
  79. pmc Evidence suggesting a transcortical pathway from cutaneous foot afferents to tibialis anterior motoneurones in man
    J Nielsen
    Physiologisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    J Physiol 501:473-84. 1997
    ..5. It is suggested that the long-latency reflexes in the tibialis anterior muscle evoked by activation of cutaneous afferents from the human foot are, at least partly, mediated by a transcortical pathway.
  80. doi Versatility of the pedicled peroneal artery perforator flaps for soft-tissue coverage of the lower leg and foot defects
    Ting Chen Lu
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, 5, Fu Hsing St Kuei Shan, Taoyuan, Taiwan
    J Plast Reconstr Aesthet Surg 64:386-93. 2011
    Even a small defect in the lower leg and foot with exposure of bones or tendons can result in an intractable wound, which may require a microsurgical tissue transfer...
  81. ncbi Foot positioning instruction, initial vertical load position and lifting technique: effects on low back loading
    Idsart Kingma
    Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
    Ergonomics 47:1365-85. 2004
    This study investigated the effects of initial load height and foot placement instruction in four lifting techniques: free, stoop (bending the back), squat (bending the knees) and a modified squat technique (bending the knees and rotating ..
  82. doi Foot pressure differences in men and women
    A B Putti
    Institute of Motion Analysis and Research IMAR, University of Dundee, TORT Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Foot Ankle Surg 16:21-4. 2010
    ..Anthropometric studies have shown considerable differences in the foot bones of both genders. These differences could potentially mean different foot pressures in men and women.
  83. doi Recovery from forward loss of balance in young and older adults using the stepping strategy
    Christopher P Carty
    School of Physiotherapy and Exercise Science, Griffith Health Institute, Griffith University, Gold Coast, Queensland 4222, Australia
    Gait Posture 33:261-7. 2011
    ..MoS at foot contact and at maximal knee joint flexion angle following foot contact (KJ(MAX)) were smaller in older compared to ..
  84. ncbi Re-weighting of somatosensory inputs from the foot and the ankle for controlling posture during quiet standing following trunk extensor muscles fatigue
    Nicolas Vuillerme
    Laboratoire TIMC IMAG, Faculte de Medecine, UMR UJF CNRS 5525, 38706, La Tronche Cedex, France
    Exp Brain Res 183:323-7. 2007
    ..muscles fatigue on postural control during quiet standing under different somatosensory conditions from the foot and the ankle...
  85. ncbi Comparison of the use of a foot pump with the use of low-molecular-weight heparin for the prevention of deep-vein thrombosis after total hip replacement. A prospective, randomized trial
    D Warwick
    University Department of Orthopaedics, Avon Orthopaedic Centre, Bristol, United Kingdom
    J Bone Joint Surg Am 80:1158-66. 1998
    We conducted a prospective, randomized trial to compare the safety and effectiveness of the A-V Impulse System foot pump with that of low-molecular-weight heparin for reducing the prevalence of deep-vein thrombosis after total hip ..
  86. doi Linear dependence of peak, mean, and pressure-time integral values in plantar pressure images
    N L W Keijsers
    Department of Research, Development and Education, Sint Maartenskliniek, PO Box 9011, 6500 GM Nijmegen, The Netherlands
    Gait Posture 31:140-2. 2010
  87. doi Tendon disorders of the foot and ankle, part 3: the posterior tibial tendon
    George S Gluck
    Department of Orthopaedic Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Am J Sports Med 38:2133-44. 2010
    ..The tibialis posterior musculotendinous unit is the most powerful inverter of the foot and an important dynamic stabilizer of the arch...
  88. doi Common inhibitory prefrontal activation during inhibition of hand and foot responses
    Hayato Tabu
    Human Brain Research Center, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Neuroimage 59:3373-8. 2012
    ..of response inhibition, we performed the event-related fMRI study of Stop signal tasks using the hand and foot response to reveal the common prefrontal region relevant for response inhibition in 13 subjects...
  89. doi Gait, balance and plantar pressures in older people with toe deformities
    Karen J Mickle
    Biomechanics Research Laboratory, University of Wollongong, NSW 2522, Australia
    Gait Posture 34:347-51. 2011
    ..These findings suggest that toe deformities alter weight distribution under the foot when walking, but that the relationship between toe deformities and falls may be mediated by factors other than ..
  90. ncbi Fresh-frozen structural allografts in the foot and ankle
    Mark S Myerson
    Union Memorial Hospital, Baltimore, Maryland, USA
    J Bone Joint Surg Am 87:113-20. 2005
    The purpose of this study was to review the results of using structural fresh-frozen femoral head allografts in foot and ankle procedures...
  91. doi The influence of foot posture on the cost of transport in humans
    C B Cunningham
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Biol 213:790-7. 2010
    ..In this study, we tested the hypothesis that plantigrade foot posture reduces the energetic cost of transport (COT) during walking in humans...
  92. ncbi Strategies for dynamic stability during adaptive human locomotion
    Aftab E Patla
    Gait and Posture Lab, University of Waterloo, Waterloo, Ontario, Canada
    IEEE Eng Med Biol Mag 22:48-52. 2003
  93. doi Evaluation of two self-referent foot health instruments
    Robert Trevethan
    Charles Sturt University, Albury, NSW, Australia
    Foot (Edinb) 20:101-8. 2010
    Two foot health inventories, the Foot Function Index and the Foot Health Status Questionnaire, are evaluated in terms of the developmental procedures used to create them...
  94. ncbi A three-dimensional shank-foot model to determine the foot motion during landings
    Adamantios Arampatzis
    German Sport University of Cologne, Institute for Biomechanics, 50933 Cologne, Germany
    Med Sci Sports Exerc 34:130-8. 2002
    The purposes of this study were a) to develop a model of the foot capable of describing the foot motion during dynamic movements and b) to study the influence of different mats on foot motion during landing in gymnastics.
  95. pmc Foot anatomy specialization for postural sensation and control
    W G Wright
    Temple University, Philadelphia, PA, USA
    J Neurophysiol 107:1513-21. 2012
    Anthropological and biomechanical research suggests that the human foot evolved a unique design for propulsion and support...
  96. ncbi Foot, hand, face and eye representation in the human striatum
    Emmanuel Gerardin
    Service Hospitalier Frederic Joliot, Department of Medical Research, CEA, Orsay, France
    Cereb Cortex 13:162-9. 2003
    The present study aimed at determining the three-dimensional organization of striatal activation during foot, hand, face and eye movements. Seven right-handed, healthy volunteers were studied at 1...
  97. ncbi Effects of contrast baths on skin blood flow on the dorsal and plantar foot in people with type 2 diabetes and age-matched controls
    Jerrold Petrofsky
    Department of Physical Therapy, Loma Linda University, Loma Linda, California 92350, USA
    Physiother Theory Pract 23:189-97. 2007
    ..Fourteen people with type 2 diabetes were compared to 14 age-matched controls. Skin blood flow of the foot (BF) was measured during 16 minutes of contrast baths at two different intervals: 3 minutes warm and 1 minute cold ..
  98. ncbi The feet of overweight and obese young children: are they flat or fat?
    Karen J Mickle
    Biomechanics Research Laboratory, Department of Biomedical Science, University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia
    Obesity (Silver Spring) 14:1949-53. 2006
  99. ncbi Preliminary normative values for foot loading parameters of the developing child
    Kerstin Bosch
    Movement Analysis Lab, Orthopaedic Department, University Hospital Munster, Munster, Germany
    Gait Posture 26:238-47. 2007
    The purpose of the present study was to provide normative data for foot loading patterns and foot shape parameters in order to support decisions about the normal or abnormal development of the growing foot during childhood...
  100. pmc Lower-extremity amputation risk after charcot arthropathy and diabetic foot ulcer
    Min Woong Sohn
    Center forManagement of Complex Chronic Care, Hines Veterans Affairs Hospital, Hines, Illinois, USA
    Diabetes Care 33:98-100. 2010
    To compare risks of lower-extremity amputation between patients with Charcot arthropathy and those with diabetic foot ulcers.
  101. pmc Chemotherapy-associated changes of histopathological features of Mycobacterium ulcerans lesions in a Buruli ulcer mouse model
    Marie Therese Ruf
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Antimicrob Agents Chemother 56:687-96. 2012
    ..Results demonstrate that the experimental M. ulcerans mouse infection model will be a valuable tool to investigate efficacy of new treatment regimens and of candidate vaccines...

Research Grants84

  1. Wound EMR to Decrease Limb Amputations in Persons with Diabetes
    Harold Brem; Fiscal Year: 2010
    ..Wound Electronic Medical Record (OWEMR) as a clinical intervention tool reduces amputations resulting from diabetic foot ulcers (DFUs) in a variety of healthcare settings...
  2. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..The success of this project will help the VA patient population immensely because both psoriasis and arthritis related sickness is a major problem among this group of patients. ..
  3. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..As many as 15% of patients with diabetes will suffer from a diabetic foot ulcer and, of these patients, 6% will be hospitalized due to infection or other ulcer-related complications...
  4. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..and CMT patients suffer from degeneration of the peripheral nerves that control sensory information of the foot/leg and hand/arm. The nerve degeneration causes the subsequent degeneration of the muscles in the extremities...
  5. Targeting p53-Dependent Repigmentation in Vitiligo
    TAMARA G TERZIAN; Fiscal Year: 2013
    ..To accomplish this, she will use 2 mouse models: 1) The Sooty Foot Ataxia mouse model which expresses a high level of p53 and has a hyperpigmented skin;hyperpigmentation is the ..
    J Evan Sadler; Fiscal Year: 2013
    ..Completion of this program will prepare talented trainees for careers in basic and translational hematology research, to make discoveries that will transform the diagnosis and treatment of hematologic diseases. ..
  7. Role of Endocytosis and Vesicular Trafficking in Podocyte Health and Filter Integ
    Puneet Garg; Fiscal Year: 2012
    ..membrane, and the "slit diaphragm" or specialized intercellular junction that lies between the interdigitating foot processes of the visceral epithelial cells (podocyte)...
  8. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..diabetic neuropathy (PDN) is the most devastating complication of diabetes mellitus, and a leading cause of foot amputation...
  9. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..8 increased fall risk [7]; an important emerging risk factor for foot ulcer non-healing...
  10. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    ..a community needs assessment persons of Hmong origin with T2DM and found that only 13 percent had ever received a foot check, 30 percent reported having a dilated eye exam in the last year, as few as 35 percent had seen a diabetic ..
  11. Characterizing Ankle Function During Sloped Locomotion For Prosthesis Development
    Alena Grabowski; Fiscal Year: 2012
    ..have regained normative function during level-ground walking due to the development of a new powered ankle-foot prosthesis...
  12. Arm Exercise versus Other Stress Test Modalities for Clinical Outcome Prediction
    WADE HAMPTON MARTIN; Fiscal Year: 2013
    ..Because of previous combat injuries, amputations, leg or foot joint, spinal cord, circulatory and other lower extremity disabilities, 20-40% of such patients are evaluated with ..
  13. Predictors of sleep-dependent Memory Consolidation in Obstructive Sleep Apnea
    Ina E Djonlagic; Fiscal Year: 2013
    ..Ultimately, this research has the opportunity to provide critical information that may in due course alter how sleep apnea is defined and thus provide a major impact on the care of sleep apnea patients. ..
  14. Epigenetics and choline: mediation of fetal alcohol effects in a rat model
    Carol L Cheatham; Fiscal Year: 2013
    ..In addition, the DHMRI maintains a 40,000 square foot vivarium with top-of-the-line equipment...
  15. Gross Hall Animal Resource Center
    Susan V Bryant; Fiscal Year: 2010
  16. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013 Doppler flow), nerve conduction velocity ("NCV", per electromyography, "EMG"), and muscle strength (by foot pressure on a walking surface) with simultaneous plasma concentrations of CM in order to construct a PD profile...
  17. Community Ambulation Following Hip Fracture
    Jay Magaziner; Fiscal Year: 2013
    ..This study will evaluate a 16-week multi-component exercise program provided to patients in their homes to determine if it is effective in improving the ability to walk independently in the community (i.e., community ambulation). ..
  18. North Lawndale Diabetes Community Action Project
    STEVEN contact WHITMAN; Fiscal Year: 2010
    ..measure (SDSCA), a validated instrument assessing general diet, specific diet, exercise, blood-glucose testing, foot care, and smoking behaviors. It will be administered at baseline and 1-yr anniversary follow-up...
  19. Foot Bone Motion in End Stage Ankle Arthritis Patients
    William R Ledoux; Fiscal Year: 2012
    ..e., pain), the patient is left with a fused ankle, which results in the distal foot joints (subtalar, midtarsal and tarsometatarsal) being stretched into increased dorsiflexion during the push off ..
  20. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    ..CMT affects both motor and sensory nerves. A typical characteristic includes weakness of the foot and lower leg muscles, which may result in foot drop and a high-stepped gait with frequent tripping or falls...
  21. Regional Biocontainment Laboratory
    Charles Bailey; Fiscal Year: 2007
    George Mason University (GMU) proposes construction of an 83,154 square foot Regional Biocontainment Laboratory (RBL) designed to support the research objectives of the National Institute of Allergy and Infectious Diseases (NIAID) for ..
  22. Improve Wound Healing with HIF-CA5 DNA Vector and Electroporation
    John W Harmon; Fiscal Year: 2010
    ..Patients with diabetes are at risk for developing foot ulcers...
  23. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012
    ..Approximately 15% of community-dwelling persons over age 65 have chronic pain in the foot and ankle, including many Vietnam veterans...
    Addanki P Kumar; Fiscal Year: 2012 transient expression assays using FLIP deletion constructs, co-transfections, gel mobility shift assays, DNase I foot printing and ChIP assays. Specific aim 3: Determine the precise role of FLIP in 2-ME induced apoptosis...
  25. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..complications of diabetes mellitus, affecting more than 50% of diabetic patients, and is the leading cause of foot amputation...
  26. IRES-mediated translation initiation on viral mRNAs
    ..PUBLIC HEALTH RELEVANCE: The genomes of a number of viruses, including poliovirus, hepatitis C virus and foot-and-mouth disease virus contain structured RNA elements known as `internal ribosomal entry sites'that promote ..
  27. Merkel cells specify innervating SAI sensory neuron phenotype.
    Erin G Reed-Geaghan; Fiscal Year: 2013
    ..These experiments will determine the molecular cascades involved in SAI identity and the peripheral contribution to these processes. ..
  28. Effects of Metabolic Disorders on Bone Marrow-Derived Cell Function
    Gina C Schatteman; Fiscal Year: 2012
    ..S. and are associated with increased risk for stroke, myocardial infarction, peripheral vascular disease, and foot ulcers...
  29. Improving Air Quality for Laboratory Animal Research
    Sharron S Quisenberry; Fiscal Year: 2010
    ..A Project Liaison Officer will assist with communications and coordination among the key scientists and other Key Personnel. ..
  30. The role of NFAT in podocyte damage and proteinuric kidney disease
    ALEXIS JOANNA SLOAN; Fiscal Year: 2013
    ..These animals develop profound proteinuria within fours days of doxycycline exposure and display foot process effacement upon analysis with electron microscopy...
  31. The Role of Kappa Opioid Receptor-induced Activation of Astrocytes in the Reinsta
    Charles Chavkin; Fiscal Year: 2009
    ..released during exposure to repeated behavioral stressors (repeated forced swim, repeated social defeat, or foot shock), strongly potentiate the rewarding effects of cocaine in mice (as measured by an enhanced conditioned place ..
  32. Contribution of Sperm Nucleus to Paternal DNA Replication
    WILLIAM S WARD; Fiscal Year: 2013
    ..This application proposes to test the idea that the sperm cell brings to the egg more than only the DNA, itself, but instructions on how to replicate it properly in the first embryonic cell division. ..
  33. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    ..Diabetic foot complications account for the majority of lower limb amputations in the world, and 25% of all diabetic hospital ..
  34. Development of Cytokine-Inhibiting Gels for Treating Chronic Wounds
    Newell R Washburn; Fiscal Year: 2010
    ..Diabetic foot ulcers cost tens of thousands of dollars to treat and are the leading cause of lower extremity amputation...
  35. Modulated Imaging in Comprehensive Assessment of Diabetic Foot Ulcer Development
    Amaan Mazhar; Fiscal Year: 2012
    ..b>Foot ulceration continues to be a major comorbidity of diabetes and afflicts as many as 15 to 25% of subjects with type ..
  36. The Role of BAF53b Mediated Nucleosome Remodeling in Long-Term Memory Formation
    ..Findings from the proposal may lead to the discovery of novel drug targets for cognitive disorders such as like Alzheimer's disease (Fischer, et al., 2007) or addiction (Malvaez et al., 2010). ..
  37. Inhibited Intramembranous Bone Healing in Diabetes
    Philip C Trackman; Fiscal Year: 2013
    ..bone disease is a condition in which bones become weak, resulting in diminished mobility, increased risk of foot and other fractures, more severe periodontal diseases, and a generally diminished quality of life...
  38. Development of Extracellular Heat Shock Protein-90 as a Novel Topical Wound Heali
    Wei Li; Fiscal Year: 2013
    ..Treating a single diabetic foot wound costs up to $28,000 within a 24-month period...
  39. Use of small molecules that stabilize dynamin rings in podocytopathies
    Sanja Sever; Fiscal Year: 2013
    ..Podocytes are specialized cells within the glomerulus that are essential for kidney ultrafiltration. They form foot processes (FPs), highly dynamic actin-based cellular extensions that are connected by slit diaphragms...
  40. Somatosensory feedback controlling a neuroprosthesis
    Douglas J Weber; Fiscal Year: 2010
    ..Neural recordings will be made during limb movements imposed by a robot arm attached to the foot. The state variables will be measured in reference frames based in intrinsic, joint-space coordinates (i.e...
  41. Alpha actinin 4: its functions and regulation
    Hung Ying Kao; Fiscal Year: 2013
    ..cells in the kidney glomerulus that possess extensively branched cell processes, interdigitating into the unique foot processes and slit diaphragms which function as key components of the filtration barrier...
  42. FOCUS
    JEFFREY LEE CARSON; Fiscal Year: 2011
    ..abstract_text> ..
  43. Nanoscale analysis of proteomic response to novel targeted therapies for lymphoma
    ALICE CHEN FAN; Fiscal Year: 2013
    ..My career is dedicated to translational investigation for realizing the goal of individualized cancer treatment. ..
  44. Health benefits of vigorous exercise in middle-aged versus older men and women
    Paul T Williams; Fiscal Year: 2010
    ..The study was initiated in 1991 through recruitment at foot race events and through solicitation of running magazine subscribers...
  45. Molecular Mechanisms of Albumin Trafficking in Podocytes
    Judith T Blaine; Fiscal Year: 2013
    ..filtration barrier which is comprised of glomerular endothelial cells, the glomerular basement membrane, podocyte foot processes and the sub-podocyte space...
    Ethylin Wang Jabs; Fiscal Year: 2010
    ..The phenotype includes dental, craniofacial, ocular, hand, and foot abnormalities...
  47. Determinants of Quality of Life in Elderly Adults with Diabetes
    Neda Laiteerapong; Fiscal Year: 2011
    ..For example, both foot ulcers and falls likely contribute to a worse quality of life;however, foot ulcers may lead to gait instability and ..
  48. Phase-contrast enhanced X-ray imaging system for small joints of hand
    Thomas J Beck; Fiscal Year: 2010
    ..It initially attacks the small joints of the hand and foot. Recent RA research shows that early aggressive therapy is most effective, making early diagnosis essential...
  49. Liquid Crystal-Based End-of-Service-Life-Indicator for Toluene Vapor
    BHARAT R ACHARYA; Fiscal Year: 2011
    ..for the development of the new technology is two-fold: First, the high cost, requirement for power, and large foot print does not allow the sensors based on existing or emerging technologies for detection of volatile organic ..
  50. Transdermal Delivery of Deferoxamine to Prevent and Treat Diabetic Wounds
    Geoffrey C Gurtner; Fiscal Year: 2011
    ..Diabetic foot ulcers represent one of the most common sequelae of diabetes-associated dysfunction in new blood vessel growth...
  51. Reversing Non-adherence in American Indians with Diabetes Mellitus Type Two
    Marlene K Wilken; Fiscal Year: 2012
    ..QOL), and the IHS Standards of Care for Diabetes which include HbA1c, blood pressure, weight, body mass index, foot inspection, depression screen, lipid profile, creatinine, liver enzymes, and eye exam...
  52. Development and Validation of a Diagnostic Tool for Infant Head Injuries from Fal
    SUSAN SHEPS contact MARGULIES; Fiscal Year: 2010
  53. Temperature & Vasomotor Tone During the First 5 Days in Preterms Less than 1000g
    ROBIN BRITT KNOBEL; Fiscal Year: 2010
  54. Sensimmer Virtual Phaco Trainer for Cataract Surgery
    P Pat Banerjee; Fiscal Year: 2011
    ..The trainee uses both hands and both feet: right hand = phaco handpiece;left hand = nucleus manipulator;right foot = phaco pedal;left foot = microscope adjustment. Real foot pedals (e.g...
  55. Micro-RNA Molecules as Regulators of Diabetic Wound Healing
    Marjana Tomic-Canic; Fiscal Year: 2013
    ..Diabetic foot ulcers (DFUs) are one of the major complications of diabetes mellitus leadin to lower extremity amputation for ..
  56. MASP-2 Antibodies for Diabetic Neuropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2012
    ..complication for patients with long term diabetes and accounts for significant morbidity by predisposing the foot to ulceration and lower extremity amputation...
  57. Changing tau Protein Levels and tau Protein Isoforms in Mouse Models of Dementia
    Timothy M Miller; Fiscal Year: 2012
    ..This novel therapeutic strategy, if successful, would be applicable to treating human dementias. ..
    EVA LUCILLE FELDMAN; Fiscal Year: 2013
    ..We propose to increase our trainee number from 4 to 6 postdoctoral fellows per year. Efforts are made to recruit qualified women and minority students for training at all levels. ..
  59. Hands-Free Assistive Reading Technology for Persons with Disabilities
    IRENE SANDRA SCHIPPER; Fiscal Year: 2010
    ..Activated with a wireless hand/foot pedal, sip-and-puff switch, chin switch, or voice activation system, the device will offer benefits to a ..
  60. Installation of Energy-Efficient Cage Washers for Childrens Hospital Vivarium
    Philip R Johnson; Fiscal Year: 2012
    ..These new colonies must first be rederived (creation of pathogen- free mice) prior to transfer to the CTRB barrier. ..
  61. TWEAK-Induced Neuroinflammation and Cerebral Edema
    MANUEL SALVADOR YEPES; Fiscal Year: 2013
    ..Importantly, if our hypothesis is correct, our findings should indicate whether inhibition of TWEAK-Fn4 binding is a valid new target for the treatment of patients with acute ischemic stroke. ..
    Arthur Karlin; Fiscal Year: 2011
    ..heterologously expressed in cultured cells, will be tagged by photoaffinity labeling, chemical crbsslinking, and foot-printing methods...
    Dwight A Towler; Fiscal Year: 2012
    ..Project Lay Narrative: Arterial hardening in diabetes &kidney disease increases the risk for heart attacks &foot amputation...
  64. Effect of Prosthetic Foot-Ankle Stiffness on Amputee Function
    GLENN KLUTE; Fiscal Year: 2011
    ..Clinicians are well aware that foot stiffness strongly influences the mechanics of amputee gait and prescribe ESAR feet with manufacturer-identified ..
    JOSEPH L LOOMIS; Fiscal Year: 2010
    ..Most amputations are preceded by a foot ulcer, so that successfully treating, or better still preventing, foot ulcers should reduce the number of diabetes ..
  66. Contractile Hydrogel Dressing for Primary Wound Closure
    Aristidis Veves; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Acute and chronic wounds such as diabetic foot ulcers represent a major area of medical concern...
    Ge Wu; Fiscal Year: 1999
    ..This study is congruent with the national health agenda to apply quantitative techniques to significantly improve the health and well-being of the nations's elderly population over the coming decade. ..
    William Smoyer; Fiscal Year: 2001
    ..syndrome (NS), a common kidney disease in children, is characterized by retraction (effacement) of the distal "foot" processes of glomerular epithelial cells (GEC) that surround glomerular capillaries...
  69. Stimuli Responsive Topical Gels for Mechanically Assisted Wound Debridement
    Aristidis Veves; Fiscal Year: 2010
    ..damaged and/or infected tissue from thermal burn wounds and a certain subset of ischemic and necrotic diabetic foot wounds is a commonly utilized wound preparation modality before the application of fillers, dressings or grafts...
    Harold Kitaoka; Fiscal Year: 2001
    The arch of the foot is important in performing activities to provide a stable base for weight bearing, flexibility to accommodate different ground conditions, and also to dissipate loads from weight bearing...
    David Margolis; Fiscal Year: 2003
    ..More than 16 million people in the US have diabetes mellitus and 15% of them can expect to develop a foot ulcer at some point in their life...
  72. Development of a Geometric Forefoot Model: A tool for Clinical Decision Making
    Howard Hillstrom; Fiscal Year: 2007
    ..provided by applicant): It is the ultimate objective of this research team to develop a mathematical model of the foot structure that is sensitive to aberrant function and can be used to plan more effective conservative and surgical ..
  73. AMES+Brain Stimulation: Treatment for Profound Plegia in Stroke
    Paul Cordo; Fiscal Year: 2010
    ..An estimated 30% of chronic stroke patients with motor disabilities of the limbs are plegic in the hand or the foot - that is, they cannot move the hand or foot...
  74. FDG-PET Imaging in Complicated Diabetic Foot
    Abass Alavi; Fiscal Year: 2005
    ..25 percent of the 11 million Americans with diabetes suffer from peripheral neuropathy and diabetic related foot complications account for the majority of nontraumatic amputations of the lower extremity...
    John Blake; Fiscal Year: 2005
    ..This new facility is a 41,915 square foot structure with animal holding/procedure rooms (suite arrangement), veterinary services, and support space on two ..
  76. Development of a 3D cell culture model of the glomerular filtration barrier
    LESLIE BRUGGEMAN; Fiscal Year: 2009
    ..develop and characterize this 3D model, and will test requirements for the formation of mature cellular structures: foot processes, slit diaphragms, and fenestrae...
    PAUL BUREK; Fiscal Year: 2000
    Diabetic foot ulcers account for 55,000 amputations per year and are the leading cause of diabetic patient hospitalizations...
  78. Administrative Core-Interdisciplinary Ctr for Male Contraceptive Res &Drug Dev
    Joseph S Tash; Fiscal Year: 2011
    ..These will all be located on the 33,294 square foot 3rd floor of the BRC (see Figure 1, next page)...
  79. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    Gautam Ghatnekar; Fiscal Year: 2007
    ..Approximately 20 percent of patients with diabetes will develop foot ulceration in their lifetime...
  80. Metabolic MRI of Diabetic Lower Extremity Disease
    Robert L Greenman; Fiscal Year: 2010
    ..Sensory impairment and functional abnormalities of localized capillary beds often result in foot ulcers that do not heal leading to infection, osteomyelitis and amputation...
  81. Development of the Cellular Biomarker for Diabetic Foot Ulcers
    MARJANA contact TOMIC CANIC; Fiscal Year: 2010 to identify objective, quantitative bio-molecular parameters that correlate with healing outcomes for diabetic foot ulcers (DFUs)...
    ETHYLIN JABS; Fiscal Year: 1999
    ..Jackson-Weiss syndrome, unlike Crouzon, is associated with highly variable phenotypic expression and foot (rarely hand) anomalies...
  83. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2009
    ..decrease the morbidity and mortality in more than 3 million patients suffering from pressure ulcers and diabetic foot ulcers...
  84. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2009
    ..b>Foot-drop, or inability to dorsiflex the paretic ankle during the swing phase of gait and ankle instability during ..