lower extremity

Summary

Summary: The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.

Top Publications

  1. ncbi Lower extremity amputations--a review of global variability in incidence
    P W Moxey
    St George s Vascular Institute, St George s Hospital NHS Trust, London, UK
    Diabet Med 28:1144-53. 2011
  2. ncbi Multidetector row CT angiography of the abdominal aorta and lower extremities in patients with peripheral arterial occlusive disease: diagnostic accuracy and interobserver agreement
    Maurizio Romano
    Department of Surgery, University Federico II, 5, Via Pansini, 80131 Naples, Italy
    Eur J Radiol 50:303-8. 2004
  3. ncbi Lower extremity peripheral arterial disease in hospitalized patients with coronary artery disease
    Robert S Dieter
    University of Wisconsin Medical School, Madison, WI, USA
    Vasc Med 8:233-6. 2003
  4. ncbi Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells
    Nihar Ranjan Dash
    Department of Biochemistry, S C B Medical College, Cuttack, Orissa, India
    Rejuvenation Res 12:359-66. 2009
  5. ncbi Effectiveness of botulinum toxin A for upper and lower limb spasticity in children with cerebral palsy: a summary of evidence
    Marissa Barlaan Lukban
    Department of Pediatrics and Neurosciences, University of the Philippines College of Medicine, Manila, Philippines
    J Neural Transm 116:319-31. 2009
  6. ncbi Single limb exercise: pilot study of physiological and functional responses to forced use of the hemiparetic lower extremity
    Sandra A Billinger
    Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, Kansas, USA
    Top Stroke Rehabil 17:128-39. 2010
  7. ncbi Recovery in mechanical muscle strength following resurfacing vs standard total hip arthroplasty - a randomised clinical trial
    C Jensen
    Orthopaedic Research Unit, Dept of Orthopaedic Surgery and Traumatology, Odense University Hospital, Inst of Clinical Research, University of Southern Denmark, Denmark
    Osteoarthritis Cartilage 19:1108-16. 2011
  8. ncbi Effect of neuromuscular warm-up on injuries in female soccer and basketball athletes in urban public high schools: cluster randomized controlled trial
    Cynthia R Labella
    Department of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Arch Pediatr Adolesc Med 165:1033-40. 2011
  9. ncbi The effect of exercise on haemodynamics in intermittent claudication: a systematic review of randomized controlled trials
    Belinda J Parmenter
    Exercise, Health and Performance Faculty Research Group, Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia
    Sports Med 40:433-47. 2010
  10. pmc Age-related joint moment characteristics during normal gait and successful reactive-recovery from unexpected slip perturbations
    Jian Liu
    Department of Health and Human Performance, University of Houston, Houston, TX, USA
    Gait Posture 30:276-81. 2009

Detail Information

Publications332 found, 100 shown here

  1. ncbi Lower extremity amputations--a review of global variability in incidence
    P W Moxey
    St George s Vascular Institute, St George s Hospital NHS Trust, London, UK
    Diabet Med 28:1144-53. 2011
    To quantify global variation in the incidence of lower extremity amputations in light of the rising prevalence of diabetes mellitus.
  2. ncbi Multidetector row CT angiography of the abdominal aorta and lower extremities in patients with peripheral arterial occlusive disease: diagnostic accuracy and interobserver agreement
    Maurizio Romano
    Department of Surgery, University Federico II, 5, Via Pansini, 80131 Naples, Italy
    Eur J Radiol 50:303-8. 2004
    ..To evaluate the accuracy of four channel multidetector row CT angiography (MDCTA) of the abdominal aorta and lower extremities arteries compared with digital subtraction angiography (DSA)...
  3. ncbi Lower extremity peripheral arterial disease in hospitalized patients with coronary artery disease
    Robert S Dieter
    University of Wisconsin Medical School, Madison, WI, USA
    Vasc Med 8:233-6. 2003
    ..An ABI less than or equal to 0.9 or a history of previous lower extremity vascular invention was considered to be indicative of significant PAD...
  4. ncbi Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells
    Nihar Ranjan Dash
    Department of Biochemistry, S C B Medical College, Cuttack, Orissa, India
    Rejuvenation Res 12:359-66. 2009
    ..The study indicates that autologous implantation of BM-derived MSCs in nonhealing ulcers accelerates the healing process and improves clinical parameters significantly...
  5. ncbi Effectiveness of botulinum toxin A for upper and lower limb spasticity in children with cerebral palsy: a summary of evidence
    Marissa Barlaan Lukban
    Department of Pediatrics and Neurosciences, University of the Philippines College of Medicine, Manila, Philippines
    J Neural Transm 116:319-31. 2009
    ....
  6. ncbi Single limb exercise: pilot study of physiological and functional responses to forced use of the hemiparetic lower extremity
    Sandra A Billinger
    Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, Kansas, USA
    Top Stroke Rehabil 17:128-39. 2010
    ..The single limb exercise (SLE) intervention was a unique training protocol that focused only on the hemiparetic limb. Our objective was to determine the effect of the SLE intervention on cardiorespiratory fitness parameters...
  7. ncbi Recovery in mechanical muscle strength following resurfacing vs standard total hip arthroplasty - a randomised clinical trial
    C Jensen
    Orthopaedic Research Unit, Dept of Orthopaedic Surgery and Traumatology, Odense University Hospital, Inst of Clinical Research, University of Southern Denmark, Denmark
    Osteoarthritis Cartilage 19:1108-16. 2011
    ....
  8. ncbi Effect of neuromuscular warm-up on injuries in female soccer and basketball athletes in urban public high schools: cluster randomized controlled trial
    Cynthia R Labella
    Department of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Arch Pediatr Adolesc Med 165:1033-40. 2011
    To determine the effectiveness of coach-led neuromuscular warm-up on reducing lower extremity (LE) injuries in female athletes in a mixed-ethnicity, predominantly low-income, urban population.
  9. ncbi The effect of exercise on haemodynamics in intermittent claudication: a systematic review of randomized controlled trials
    Belinda J Parmenter
    Exercise, Health and Performance Faculty Research Group, Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia
    Sports Med 40:433-47. 2010
    ..Exercise did not significantly change lower extremity haemodynamics in most trials; nor were clinical improvements related to changes in resting ABI (mean ES 0...
  10. pmc Age-related joint moment characteristics during normal gait and successful reactive-recovery from unexpected slip perturbations
    Jian Liu
    Department of Health and Human Performance, University of Houston, Houston, TX, USA
    Gait Posture 30:276-81. 2009
    The objective of the current study was to investigate the effects of aging on 3D lower extremity joint moments during successful reactive-recovery from unexpected slips...
  11. ncbi The coupling between upper and lower extremity synergies during whole body reaching
    T R Kaminski
    Department of Biobehavioral Sciences, Teachers College, Columbia University, Box 199, 525 West 120th Street, New York, NY 10027, USA
    Gait Posture 26:256-62. 2007
    ..We hypothesized that the synergies that characterize upper and lower extremity movement are flexible and become coupled into one functional unit to transport the body towards the target...
  12. ncbi Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis
    K A Stockton
    School of Medicine, University of Queensland, Brisbane, QLD, Australia
    Osteoporos Int 22:859-71. 2011
    ..However, a limited number of studies demonstrate an increase in proximal muscle strength in adults with vitamin D deficiency...
  13. pmc The association between lower extremity continuous peripheral nerve blocks and patient falls after knee and hip arthroplasty
    Brian M Ilfeld
    Department of Anesthesiology, University of California San Diego, San Diego, California, USA
    Anesth Analg 111:1552-4. 2010
    ..However, none have included an adequate control group, and therefore the relationship between CPNB and falls remains speculative...
  14. ncbi Gender differences in lower extremity kinematics, kinetics and energy absorption during landing
    Michael J Decker
    Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX, USA
    Clin Biomech (Bristol, Avon) 18:662-9. 2003
    To determine whether gender differences exist in lower extremity joint motions and energy absorption landing strategies between age and skill matched recreational athletes.
  15. pmc Changes in the incidence of lower extremity amputations in individuals with and without diabetes in England between 2004 and 2008
    Eszter P Vamos
    Department of Primary Care and Public Health, Imperial College London, London, UK
    Diabetes Care 33:2592-7. 2010
    ..To describe recent trends in the incidence of nontraumatic amputations among individuals with and without diabetes and estimate the relative risk of amputations among individuals with diabetes in England...
  16. pmc Depressive symptoms and lower extremity functioning in men and women with peripheral arterial disease
    Mary Mcgrae McDermott
    Department of Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
    J Gen Intern Med 18:461-7. 2003
    Factors associated with impaired functioning in patients with lower extremity peripheral arterial disease (PAD) are not fully understood...
  17. ncbi ACC/AHA Guidelines for the Management of Patients with Peripheral Arterial Disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Associations for Vascular Surgery/Society for Vascular Surgery, Society
    Alan T Hirsch
    J Vasc Interv Radiol 17:1383-97; quiz 1398. 2006
  18. ncbi The effect of botulinum toxin type A treatment of the lower extremity on the level of functional abilities in children with cerebral palsy: evaluation with goal attainment scaling
    Duco Steenbeek
    Rehabilitation Centre Breda, The Netherlands
    Clin Rehabil 19:274-82. 2005
    ..To measure the effect of botulinum toxin type A (BTX-A) treatment in children with cerebral palsy with regard to individual goals concerning functional abilities, using goal attainment scaling...
  19. ncbi Lower extremity muscle perforator flaps for lower extremity reconstruction
    Geoffrey G Hallock
    Division of Plastic Surgery, The Lehigh Valley Hospital, Allentown, PA, USA
    Plast Reconstr Surg 114:1123-30. 2004
    ..Adhering to this definition, several lower extremity donor sites now are available, each with specific attributes especially useful for consideration in the ..
  20. ncbi Botulinum toxin assessment, intervention and after-care for lower limb spasticity in children with cerebral palsy: international consensus statement
    S C Love
    Centre for Musculoskeletal Studies, University of Western Australia, Princess Margaret Hospital, Perth, Western Australia, Australia
    Eur J Neurol 17:9-37. 2010
    ....
  21. ncbi Lower-extremity muscle forces measured by a hand-held dynamometer and the risk of falls among day-care users in Japan: using multinomial logistic regression analysis
    Kotaro Takazawa
    Department of Preventive Medicine and Health Promotion, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Disabil Rehabil 25:399-404. 2003
    To assess the relationship between the lower extremity muscle forces and risk of falls among the elderly who were using day-care services in the long-term care insurance system.
  22. ncbi Factors associated with phantom limb pain: a 31/2-year prospective study
    Joline C Bosmans
    Department of Rehabilitation Medicine and Graduate School for Health Research SHARE, University Medical Centre Groningen, University of Groningen
    Clin Rehabil 24:444-53. 2010
    ..To analyse the prevalence of phantom (limb) pain over time and to analyse factors associated with phantom (limb) pain in a prospective cohort of amputees...
  23. ncbi MR imaging of entrapment neuropathies of the lower extremity. Part 2. The knee, leg, ankle, and foot
    Andrea Donovan
    Department of Radiology, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada
    Radiographics 30:1001-19. 2010
    ..The causes of most entrapment neuropathies in the lower extremity may be divided into two major categories: (a) mechanical causes, which occur at fibrous or fibro-osseous ..
  24. ncbi The Italian version of the lower extremity functional scale was reliable, valid, and responsive
    Angelo Cacchio
    Department of Physical Medicine and Rehabilitation, School of Medicine, University of Roma La Sapienza, P le A Moro 5, 00185 Roma, Italy
    J Clin Epidemiol 63:550-7. 2010
    To determine the measurement properties of an Italian Version of the Lower Extremity Functional Scale (LEFS) in patients with lower extremity musculoskeletal dysfunction.
  25. pmc A retrospective analysis of amputation rates in diabetic patients: can lower extremity amputations be further prevented?
    Alexandra Alvarsson
    Rolf Luft Centre for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Cardiovasc Diabetol 11:18. 2012
    b>Lower extremity amputations are costly and debilitating complications in patients with diabetes mellitus (DM)...
  26. ncbi Asymptomatic peripheral arterial disease is associated with more adverse lower extremity characteristics than intermittent claudication
    Mary M McDermott
    Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    Circulation 117:2484-91. 2008
    ..This study assessed functional performance, calf muscle characteristics, peripheral nerve function, and quality of life in asymptomatic persons with peripheral arterial disease (PAD)...
  27. pmc Trends in initial lower extremity amputation rates among Veterans Health Administration health care System users from 2000 to 2004
    Chin Lin Tseng
    Department of Veterans Affairs New Jersey Healthcare System Center for Healthcare Knowledge Management, East Orange, New Jersey, USA
    Diabetes Care 34:1157-63. 2011
    To evaluate temporal trends in rates of initial lower extremity amputation (ILEA) among patients with diabetes in the Veterans Health Administration (VHA).
  28. ncbi Effects of leg muscle botulinum toxin A injections on walking in children with spasticity-related cerebral palsy: a systematic review
    Ulrike Ryll
    Department of Epidemiology, Caphri Research Institute, Maastricht University, Maastricht, The Netherlands
    Dev Med Child Neurol 53:210-6. 2011
    ..To assess treatment effects of botulinum toxin type A (BoNT-A) on walking of children with leg spasticity due to cerebral palsy (CP) compared with usual care...
  29. ncbi An analytical formulation of the law of intersegmental coordination during human locomotion
    Avi Barliya
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Isreal
    Exp Brain Res 193:371-85. 2009
    ..Implications of this study with respect to neural control of locomotion and other motor activities are discussed...
  30. pmc Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease
    Laura H Eggermont
    Alzheimer s Disease Clinical and Research Program, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Arch Phys Med Rehabil 91:584-8. 2010
    ..To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD)...
  31. ncbi The effect of lower extremity selective voluntary motor control on interjoint coordination during gait in children with spastic diplegic cerebral palsy
    Eileen G Fowler
    Department of Orthopaedic Surgery, University of California at Los Angeles, Los Angeles, CA 90095, United States
    Gait Posture 29:102-7. 2009
    ..These tracts are responsible for the production of selective voluntary motor control (SVMC). Lower extremity motor control has been suggested as being an important predictor of improvement following interventions...
  32. pmc The relationship between time to surgical debridement and incidence of infection after open high-energy lower extremity trauma
    Andrew N Pollak
    University of Maryland School of Medicine, 22 South Greene Street, Suite T3R54, Baltimore, MD 21201, USA
    J Bone Joint Surg Am 92:7-15. 2010
    ..The purpose of the present study was to evaluate the relationship between the timing of the initial treatment of open fractures and the development of subsequent infection as well as to assess contributing factors...
  33. ncbi Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery
    Michael S Conte
    Division of Vascular Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Vasc Surg 43:742-751; discussion 751. 2006
    ....
  34. ncbi Lower extremity lymphedema update: pathophysiology, diagnosis, and treatment guidelines
    Katherine Kerchner
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Acad Dermatol 59:324-31. 2008
    b>Lower extremity lymphedema is an important medical issue which causes morbidity and is frequently seen by dermatologists. The subject has not been adequately addressed in dermatologic literature for many years...
  35. ncbi Chronic lower extremity lymphedema: a comparative study of high-resolution interstitial MR lymphangiography and heavily T2-weighted MRI
    Qing Lu
    Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Rd, Shanghai 200127, China
    Eur J Radiol 73:365-73. 2010
    ..To assess the role of heavily T2-weighted image and interstitial MR lymphangiography (MRL) for the visualization of lymphatic vessels in patients with disorders of the lymphatic circulation...
  36. ncbi Partial weight bearing after surgery for fractures of the lower extremity--is it achievable?
    Attila Vasarhelyi
    Abteilung für Unfall und Wiederherstellungschirurgie Klinik und Poliklinik für Chirurgie, Universitat Rostock, Schillingallee 35, 18055 Rostock, Germany
    Gait Posture 23:99-105. 2006
    ..bearing is a generally accepted principle of rehabilitation following trauma or reconstructive surgery of the lower extremity. Individual dynamic loads during partial weight bearing to a given load level of 200 N were compared in 23 ..
  37. pmc Prevalence of degenerative joint complaints of the lower extremity: a representative study
    G Horvath
    Department of Orthopedics, Faculty of Medicine, University of Pecs, Ifjúság Street 13, 7643, Pecs, Hungary
    Int Orthop 30:118-22. 2006
    ..Details of the survey and the possible causes of the higher prevalence are discussed, along with the results of the SF-36 questionnaire...
  38. ncbi The use of prolonged peripheral neural blockade after lower extremity amputation: the effect on symptoms associated with phantom limb syndrome
    Battista Borghi
    Department of Surgery and Anesthesiology Sciences, University of Bologna, Bologna, Italy
    Anesth Analg 111:1308-15. 2010
    ..Therefore, we evaluated the efficacy of a prolonged perineural infusion of a high concentration of local anesthetic solution in preventing PLS...
  39. pmc Eccrine porocarcinoma of the lower extremity: a case report and review of literature
    Oliver Chang
    General Surgery Department, The Brooklyn Hospital, NY, USA
    World J Surg Oncol 9:94. 2011
    ..In our case, we present a 42-year-old male patient with a recurring exophytic tumor on the right lower extremity without local extension. The initial tumor was biopsied, excised and diagnosed as an eccrine poroma...
  40. ncbi Characteristic indocyanine green lymphography findings in lower extremity lymphedema: the generation of a novel lymphedema severity staging system using dermal backflow patterns
    Takumi Yamamoto
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Plast Reconstr Surg 127:1979-86. 2011
    ..The purpose of this study was to describe, analyze, and classify characteristic indocyanine green lymphography findings to uniformly guide surgical management of lymphedema using this modality...
  41. pmc Respiratory and skeletal muscle strength in chronic obstructive pulmonary disease: impact on exercise capacity and lower extremity function
    Jonathan Singer
    Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco, California 94143, USA
    J Cardiopulm Rehabil Prev 31:111-9. 2011
    We sought to quantify the impact of respiratory muscle and lower extremity strength on exercise capacity and lower extremity function (LEF) in patients with chronic obstructive pulmonary disease (COPD).
  42. pmc Genetic ancestry and lower extremity peripheral artery disease in the Multi-Ethnic Study of Atherosclerosis
    Matthew A Allison
    Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0965, USA
    Vasc Med 15:351-9. 2010
    ....
  43. ncbi Stress fractures in the lower extremity. The importance of increasing awareness amongst radiologists
    Ferco H Berger
    Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam ZO, The Netherlands
    Eur J Radiol 62:16-26. 2007
    ..Specific fracture sites in the lower extremity will be addressed, covering the far majority of stress fracture incidence...
  44. ncbi Does lower limb preference influence gait initiation?
    Yoann Dessery
    Univ Lille Nord de France, F 59000 Lille, France
    Gait Posture 33:550-5. 2011
    ..This may have clinical relevance especially in individuals with unilateral limb dyscontrol and postural asymmetry that may require rehabilitation...
  45. ncbi The risk of child abuse in infants and toddlers with lower extremity injuries
    Carla Coffey
    The Trauma Program, Children s Hospital, Columbus, OH 43205, USA
    J Pediatr Surg 40:120-3. 2005
    The aim of this study was to assess the risk of child abuse in children younger than 18 months admitted to a pediatric trauma service with lower extremity injuries.
  46. ncbi Psoas compartment block for lower extremity surgery: a meta-analysis
    S T Touray
    Department of Anaesthesia and Pain Medicine, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Br J Anaesth 101:750-60. 2008
    ..More research is required to define its role in the intraoperative setting and confirm potentially beneficial effects on variables such as perioperative haemodynamics and blood loss...
  47. ncbi Lower extremity reconstruction
    Lior Heller
    Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Surg Oncol 94:479-89. 2006
    The current recommendation for surgical treatment of tumors of the lower extremity is a limb-sparing resection...
  48. ncbi Changes in postural stability with fatigue of lower extremity frontal and sagittal plane movers
    Mahyar Salavati
    University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
    Gait Posture 26:214-8. 2007
    ..In conclusion, fatigue of proximal lower extremity muscles affects postural stability and fatigue of the frontal movers is associated with postural instability ..
  49. pmc High dose botulinum toxin A for the treatment of lower extremity hypertonicity in children with cerebral palsy
    Allison W Willis
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Dev Med Child Neurol 49:818-22. 2007
    ..of high dose (15-25 units/kg) of botulinum toxin A (BTX-A) in children with cerebral palsy (CP) and increased lower extremity muscle tone...
  50. pmc Lower extremity power training in elderly subjects with mobility limitations: a randomized controlled trial
    Kieran F Reid
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Aging Clin Exp Res 20:337-43. 2008
    This study investigated whether high-velocity high-power training (POW) improved lower extremity muscle power and quality in functionally-limited elders greater than traditional slow-velocity progressive resistance training (STR).
  51. pmc Leg muscle strength is reduced in Parkinson's disease and relates to the ability to rise from a chair
    Lisa M Inkster
    School of Rehabilitation Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Mov Disord 18:157-62. 2003
    ..We compared lower extremity strength between individuals with PD and healthy controls and quantified the relationships between strength ..
  52. ncbi Diabetes as an independent risk factor for early postoperative complications in critical limb ischemia
    Jyrki Virkkunen
    Department of Surgery, Central Hospital for Central Finland, Jyvaskyla
    J Vasc Surg 40:761-7. 2004
    ..The purpose of this study was to evaluate the significance of diabetes mellitus as a risk factor for postoperative major morbidity and mortality after surgery for critical lower limb ischemia (CLI)...
  53. ncbi Psychosocial predictors of long-term adjustment to lower-limb amputation and phantom limb pain
    Marisol A Hanley
    Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6490, USA
    Disabil Rehabil 26:882-93. 2004
    ..To evaluate the utility of a biopsychosocial model to predict long-term adjustment to lower-limb amputation and phantom limb pain (PLP)...
  54. ncbi Sports-related muscle injury in the lower extremity
    Derek R Armfield
    Department of Radiology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Clin Sports Med 25:803-42. 2006
  55. ncbi Fractures following radiotherapy and limb-salvage surgery for lower extremity soft-tissue sarcomas. A comparison of high-dose and low-dose radiotherapy
    Ginger E Holt
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    J Bone Joint Surg Am 87:315-9. 2005
    The purpose of the present retrospective study was to determine the correlation between radiation therapy and the risk of postradiation fracture following combined therapy for the treatment of soft-tissue sarcomas of the lower extremity.
  56. ncbi The 180-degree perforator-based propeller flap for soft tissue coverage of the distal, lower extremity: a new method to achieve reliable coverage of the distal lower extremity with a local, fasciocutaneous perforator flap
    Rafael G Jakubietz
    Department of Plastic, Reconstructive and Hand Surgery, Kantonsspital St Gallen, St Gallen, Switzerland
    Ann Plast Surg 59:667-71. 2007
    ..When a local perforator flap is designed as a 180-degree propeller flap, an excellent esthetic result and direct closure of the donor site can be achieved, with minimal morbidity...
  57. pmc Evaluation of cuff-induced ischemia in the lower extremity by magnetic resonance oximetry
    Michael C Langham
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 55:598-606. 2010
    ....
  58. ncbi The effects of plyometric versus dynamic stabilization and balance training on lower extremity biomechanics
    Gregory D Myer
    Cincinnati Children s Hospital, 3333 Burnet Avenue, MLC 10001, Cincinnati, OH 45229, USA
    Am J Sports Med 34:445-55. 2006
    ..The biomechanical effects of plyometric and balance training utilized separately are unknown...
  59. ncbi Instruction of jump-landing technique using videotape feedback: altering lower extremity motion patterns
    James A Onate
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Sports Med 33:831-42. 2005
    ..Anterior cruciate ligament injury prevention programs have used videotapes of jump-landing technique as a key instructional component to improve landing performance...
  60. ncbi MR imaging of entrapment neuropathies of the lower extremity. Part 1. The pelvis and hip
    Catherine N Petchprapa
    Department of Radiology, New York University Hospital for Joint Diseases, 301 E 17th St, New York, NY 10003, USA
    Radiographics 30:983-1000. 2010
    ..Diagnosis of entrapment neuropathies of the pelvis and hip with MR imaging requires familiarity with the normal MR imaging anatomy and awareness of the anatomic and pathologic factors that put peripheral nerves at risk for injury...
  61. ncbi Three-dimensional lower extremity alignment in the weight-bearing standing position in healthy elderly subjects
    Akihiro Ariumi
    Department of Orthopaedic Surgery, Niigata Kobari Hospital, Kobari, Niigata, Japan
    J Orthop Sci 15:64-70. 2010
    Although assessment of lower extremity alignment is important for the treatment and evaluation of diseases that present with malalignment of the lower extremity, it has generally been performed using only plain radiographs seen in two ..
  62. ncbi Current trends in lower extremity revascularization
    Ganesha B Perera
    Department of Vascular Surgery, Desk S40, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Surg Clin North Am 87:1135-47, x. 2007
    Femoropopliteal bypass is the traditional management of superficial femoral artery lower extremity athero-occlusive disease for lifestyle-limiting claudication and critical limb ischemia...
  63. ncbi Lower extremity muscle quality and gait variability in older adults
    Sunghoon Shin
    Kinesiology and Community Health, University of Illinois at Urbana Champaign, 906 S Goodwin Ave, Urbana, IL 61801, USA
    Age Ageing 41:595-9. 2012
    it is not clear if gait variability is linked to muscle strength or muscle quality (MQ). This study examined the relation between leg strength and lower extremity MQ and gait variability in healthy ambulatory older adults.
  64. ncbi National trauma databank analysis of mortality and limb loss in isolated lower extremity vascular trauma
    David S Kauvar
    Division of Vascular Surgery, University of Utah, Salt Lake City, Utah 84103, USA
    J Vasc Surg 53:1598-603. 2011
    b>Lower extremity injury is common in trauma patients; however, the influence of arterial injury on devastating patient and limb outcomes can be confounded by the presence and physiological derangement of concomitant head or ..
  65. ncbi A prospective study of positive adjustment to lower limb amputation
    Jennifer Unwin
    Division of Clinical Psychology, Whelan Building, University of Liverpool, Liverpool L69 3GB, UK
    Clin Rehabil 23:1044-50. 2009
    ..To examine prospectively the influence of demographic, amputation and psychosocial variables on positive psychological adjustment outcomes for lower limb amputees...
  66. ncbi Lower limb cellulitis after a typhoon and flood
    Hung Jung Lin
    Epidemiology 18:410. 2007
  67. ncbi Association of suboptimal prescribing and change in lower extremity physical function over time
    Mary Jo V Pugh
    South Texas Veterans Health Care System Verdict, University of Texas Health Science Center at San Antonio, San Antonio, Tex, USA
    Gerontology 53:445-53. 2007
    ..This study explores the relationship between suboptimal prescribing, comorbid disease, and change in lower extremity functional limitation (LEFL).
  68. ncbi Lambda-shaped anastomosis with intravascular stenting method for safe and effective lymphaticovenular anastomosis
    Takumi Yamamoto
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Plast Reconstr Surg 127:1987-92. 2011
    ..A positive correlation between the number of lymphaticovenular anastomoses performed and therapeutic efficacy has been reported, and in performing these anastomoses, the establishment of as many bypasses as possible is important...
  69. ncbi Depression is associated with worse patency and recurrent leg symptoms after lower extremity revascularization
    Gregory S Cherr
    Division of Vascular Surgery, State University of New York at Buffalo, Buffalo, NY 14203, USA
    J Vasc Surg 45:744-50. 2007
    ..This study assessed the association between depression and patency, recurrent symptoms, and limb salvage after revascularization for symptomatic PAD...
  70. ncbi Provider volume and outcomes for abdominal aortic aneurysm repair, carotid endarterectomy, and lower extremity revascularization procedures
    Shane D Killeen
    Department of Academic Surgery, National University of Ireland NUI University College Cork UCC, Cork University Hospital, Cork, Ireland
    J Vasc Surg 45:615-26. 2007
    ..Although a large number of studies assess the relationship between volume and outcome, a single contemporary compilation of such studies is lacking...
  71. ncbi Predictors of surgical site infection after open lower extremity revascularization
    David Yu Greenblatt
    Department of Surgery, University of Wisconsin, Madison, WI, USA
    J Vasc Surg 54:433-9. 2011
    Surgical site infection (SSI) after open surgery for lower extremity revascularization is a serious complication that may lead to graft infection, prolonged hospitalization, and increased cost...
  72. ncbi The intravascular stenting method for treatment of extremity lymphedema with multiconfiguration lymphaticovenous anastomoses
    Mitsunaga Narushima
    Department of Plastic and Reconstructive Surgery, Tokyo University School of Medicine, Tokyo, Japan
    Plast Reconstr Surg 125:935-43. 2010
    ..The authors applied the intravascular stenting method to the surgical correction of extremity lymphedema to generate multiconfiguration lymphaticovenous anastomoses capable of decompressing both proximal and distal lymphatic flow...
  73. ncbi The combination of carotid and lower extremity ultrasonography increases the detection of atherosclerosis in type 2 diabetes patients
    Lianxi Li
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
    J Diabetes Complications 26:23-8. 2012
    To evaluate the prevalence of atherosclerosis detected by both carotid and lower extremity ultrasonography in hospitalized Chinese type 2 diabetic patients and to examine whether plaque formation in the carotid arteries could be an ..
  74. ncbi Midterm outcomes from the TALON Registry: treating peripherals with SilverHawk: outcomes collection
    Venkatesh Ramaiah
    Arizona Heart Hospital, Phoenix, USA
    J Endovasc Ther 13:592-602. 2006
    To determine midterm clinical outcomes among patients with lower extremity peripheral arterial disease who underwent revascularization with catheter-based plaque excision (PE).
  75. pmc A non-rigid registration method for serial lower extremity hybrid SPECT/CT imaging
    Jung W Suh
    Department of Diagnostic Radiology, Yale University, New Haven, CT, USA
    Med Image Anal 15:96-111. 2011
    ....
  76. ncbi Lower extremity motor performance and body mass index in elderly people: the Italian Longitudinal Study on Aging
    Giuseppe Sergi
    Department of Medical and Surgical Sciences, Division of Geriatrics, University of Padova, Padova, Italy
    J Am Geriatr Soc 55:2023-9. 2007
    To test the association between body mass index (BMI) and lower extremity motor performance in elderly people.
  77. ncbi [The survival and functional outcome of primary bone sarcomas in distal lower extremity]
    Tai Qiang Yan
    Orthopaedic Oncology Department, People s Hospital, Peking University, Beijing 100044, China
    Zhonghua Wai Ke Za Zhi 48:1550-5. 2010
    ..To analyze the oncological and functional outcome of limb salvage in this location...
  78. ncbi Gender-based analysis of perioperative outcomes associated with lower extremity bypass
    Ashish K Jain
    Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Emory University School of Medicine, Atlanta, Georgia, USA
    Am Surg 77:844-9. 2011
    ..gender-based differences in preoperative factors, procedural characteristics, and 30-day outcomes after lower extremity bypass (LEB)...
  79. ncbi Gender differences in lower extremity function in Latin American elders: seeking explanations from a life-course perspective
    Beatriz Eugenia Alvarado
    Departement de Medecine sociale et preventive, Universite de Montreal, CP 6128 Succursale Centre Ville, H3C 3J7 Montreal, Quebec, Canada
    J Aging Health 19:1004-24. 2007
    ..The authors examined the contribution of life-course exposures to gender differences in mobility in later life...
  80. ncbi Lymphedema in gynecologic cancer survivors: an area for exploration?
    Suzy Lockwood-Rayermann
    Harris College of Nursing and Health Sciences, Texas Christian University, Fort Worth, TX 76129, USA
    Cancer Nurs 30:E11-8. 2007
    ..for upper extremity lymphedema following treatment of breast cancer cannot be directly transferred to lower extremity lymphedema affecting women with cancer of the ovary, cervix, uterus, and vulva because of limb size, volume, ..
  81. ncbi Reporting standards for endovascular treatment of lower extremity deep vein thrombosis
    Suresh Vedantham
    Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
    J Vasc Interv Radiol 17:417-34. 2006
  82. ncbi Treatment of critical limb ischemia using ultrasound-enhanced thrombolysis (PARES Trial): final results
    Christian Wissgott
    Department of Radiology, DRK Kliniken Mark Brandenburg, Berlin, Germany
    J Endovasc Ther 14:438-43. 2007
    ..To evaluate the safety and performance of ultrasound-enhanced thrombolysis in the treatment of acute thrombotic or embolic occlusion of the lower limb arteries...
  83. pmc Early remodeling of lower extremity vein grafts: inflammation influences biomechanical adaptation
    Christopher D Owens
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Vasc Surg 47:1235-42. 2008
    ..We sought to examine the hypothesis that systemic inflammation influences this early remodeling response...
  84. ncbi Utilization of an aspiration thrombectomy catheter (Pronto) to treat acute atherothrombotic embolization during percutaneous revascularization of the lower extremity
    Nayab Zafar
    Cardiovascular Catheterization Laboratory, San Diego, California, USA
    Catheter Cardiovasc Interv 71:972-5. 2008
    ..We present a case of acute atherothrombotic embolization to the left lower extremity after stenting of the left proximal popliteal and anterior tibial arteries...
  85. ncbi Percutaneously inserted central catheter for total parenteral nutrition in neonates: complications rates related to upper versus lower extremity insertion
    Viet Hoang
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of California, School of Medicine, Irvine, California, USA
    Pediatrics 121:e1152-9. 2008
    The objective of this study was to compare the complication rates of upper versus lower extremity percutaneously inserted central catheters used for total parenteral nutrition in neonates.
  86. ncbi Catheter-directed thrombolysis with percutaneous rheolytic thrombectomy versus thrombolysis alone in upper and lower extremity deep vein thrombosis
    Hyun S Kim
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cardiovasc Intervent Radiol 29:1003-7. 2006
    To compare the efficacy of catheter-directed thrombolysis (CDT) alone versus CDT with rheolytic percutaneous mechanical thrombectomy (PMT) for upper and lower extremity deep vein thrombosis (DVT).
  87. pmc Reliability of lower limb alignment measures using an established landmark-based method with a customized computer software program
    Elizabeth A Sled
    Queen s University, Kingston, Canada
    Rheumatol Int 31:71-7. 2011
    ..839-0.998). In conclusion, alignment measures using a bone landmark-based approach and a computer program were highly reliable between multiple readers...
  88. ncbi The effect of gait speed and gender on perceived exertion, muscle activity, joint motion of lower extremity, ground reaction force and heart rate during normal walking
    Min Chi Chiu
    Department of Industrial Engineering and Engineering Management, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    Gait Posture 25:385-92. 2007
    ..investigate the effect of speed and gender on subjective perceived exertion, muscle activity, joint motion of lower extremity, vertical ground reaction force and heart rate during barefoot walking...
  89. ncbi The modified reverse sural artery flap lower extremity reconstruction
    Mark P Foran
    Division of Plastic Surgery, Johns Hopkins Hospital and the Division of Plastic Surgery, University of Maryland, Baltimore, Maryland, USA
    J Trauma 64:139-43. 2008
    ..We hypothesized that delaying the flap (the delay time ranged from 48 hours to 2 weeks) and using a 4-cm wide pedicle would decrease the amount of partial flap necrosis that commonly occurs with this flap...
  90. ncbi The medical management of diabetes mellitus with particular reference to the lower extremity: the Jamaican experience
    R Wright-Pascoe
    Department of Medcine, University of the West Indies, Mona, Kingston, Jamiaca
    West Indian Med J 50:46-9. 2001
    ..Euglycaemia, a favourable lipid profile, control of blood pressure, yearly foot examination and institution of measures to prevent foot trauma are important in the prevention of foot ulceration...
  91. ncbi Isolated lower extremity metastases, 9 years after initial diagnosis of retinoblastoma
    M E Mulligan
    Department of Radiology, Medical School, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, USA
    Skeletal Radiol 35:774-7. 2006
    We report the development of isolated lower extremity metastases, in a child, 9 years after her initial diagnosis and treatment of bilateral infantile retinoblastomas...
  92. ncbi Microsurgery for lower extremity injuries
    Anastasios V Korompilias
    Department of Orthopaedic Surgery, University of Ioannina, School of Medicine, Ioannina 45110, Greece
    Injury 39:S103-8. 2008
    ..The flap selection criteria for lower extremity reconstruction are based on the wound surface area, the type of tissue deficiency, length of the pedicle, ..
  93. ncbi National trends in lower extremity bypass surgery, endovascular interventions, and major amputations
    Philip P Goodney
    Dartmouth Hitchcock Medical Center, Lebanon, NH 03765, USA
    J Vasc Surg 50:54-60. 2009
    Advances in endovascular interventions have expanded the options available for the invasive treatment of lower extremity peripheral arterial disease (PAD)...
  94. ncbi The lower extremity functional scale has good clinimetric properties in people with ankle fracture
    Chung Wei Christine Lin
    Musculoskeletal Division, The George Institute for International Health, PO Box M201, Missenden Rd, The University of Sydney, New South Wales, 2050 Australia
    Phys Ther 89:580-8. 2009
    ..There is limited information on the clinimetric properties of questionnaires of activity limitation in people after ankle fracture...
  95. ncbi Quantification of axial alignment of the lower extremity on conventional and digital total leg radiographs
    J Sailer
    Univ Klinik fur Radiodiagnostik, Abteilung Osteoradiologie, Medizinische Fakultät der Universität Wien, Vienna, Austria
    Eur Radiol 15:170-3. 2005
    ..001). Computer-assisted angle measurement on digital total-leg radiographs represents a reliable method with no significant angle differences compared to conventional radiographic systems and offers a significantly lower evaluation time...
  96. ncbi The use of ertapenem for the treatment of lower extremity infections
    Matthew D Nielsen
    Department of Foot and Ankle Surgery, The Western Pennsylvania Hospital, Pittsburgh, USA
    J Foot Ankle Surg 48:135-41. 2009
    b>Lower extremity infections are a growing challenge. Moderate to severe infections are frequently polymicrobial in nature and require appropriate parenteral antibiotic therapy...
  97. ncbi Reliability of lower limb frontal plane alignment measurements using plain radiographs and digitized images
    Adrian V Specogna
    University of Western Ontario, London, Ontario, Canada
    J Knee Surg 17:203-10. 2004
    ..However, the small errors associated with both methods should be considered when making clinical decisions...
  98. ncbi Does repeat duplex ultrasound for lower extremity deep vein thrombosis influence patient management?
    Enrico Ascher
    Division of Vascular Surgery, Department of Surgery, Maimonides Medical Center, Brooklyn, NY 11219, USA
    Vasc Endovascular Surg 38:525-31. 2004
    The clinical significance of lower extremity deep vein thrombus (DVT) propagation in the setting of anticoagulation therapy remains unclear...
  99. pmc Prevalence of asymptomatic critical carotid artery stenosis in Korean patients with chronic atherosclerotic lower extremity ischemia: is a screening carotid duplex ultrasonography worthwhile?
    Woo Sung Yun
    Division of Vascular Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 25:1167-70. 2010
    ..333, 95% CI: 1.169-4.657) are predictive factors of > or = 70% stenosis. A PAD patient who needs revascularization, particularly, > 65 yr or has a concomitant CAD, can be a good candidate of screening CDUS...
  100. ncbi Continuous peripheral nerve blockade in lower extremity surgery
    A M Navas
    Department of Anaesthesiology, Valme Hospital, Seville, Spain
    Acta Anaesthesiol Scand 49:1048-55. 2005
    Peripheral nerve blocks afford numerous benefits for lower extremity surgery...
  101. ncbi Modified Ashworth scale reliability for measurement of lower extremity spasticity among patients with SCI
    B C Craven
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Spinal Cord 48:207-13. 2010
    ..Observational study...

Research Grants82

  1. Wound EMR to Decrease Limb Amputations in Persons with Diabetes
    Harold Brem; Fiscal Year: 2010
    ....
  2. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..Within few weeks of injury, there are significant decrease in whole body fat-free mass (FFM), particularly lower extremity skeletal muscle mass and subsequent increase in fat mass (FM)...
  3. MR Monitoring of PTC124 Treatment in DMD
    KRISTA H VANDENBORNE; Fiscal Year: 2010
    ..damage/inflammation, muscle contractile tissue and intramuscular lipid accumulation will be performed in the lower extremity muscles prior to, and at multiple time points following initiation of PTC124 treatment...
  4. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..Therefore, the relevance of this proposal lies in its potential to improve patency of lower extremity interventions, reduce morbidity, and reduce the significant financial burden currently associated with the ..
  5. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..The purpose of the proposed three-year pilot study is to determine whether lower extremity (leg) endothelial function, exercise functions, and skeletal muscle mitochondrial gene regulation are ..
  6. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..Three important components of the proposed strategy are, 1) to assess and improve the perception of lower extremity position during challenging conditions;2) to motivate and guide simple exercise performance in a clinic/home, ..
  7. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    ..It will also define important ways in which the body can be further protected from the stresses of undergoing surgery using heart-lung bypass. (End of Abstract) ..
  8. Arm Exercise versus Other Stress Test Modalities for Clinical Outcome Prediction
    WADE HAMPTON MARTIN; Fiscal Year: 2013
    ..but none of this information is available for patients who undergo pharmacologic stress tests because of lower extremity disabilities such as amputations, knee or other arthropathies, myopathies, claudication, spinal cord, or ..
  9. Characterizing Ankle Function During Sloped Locomotion For Prosthesis Development
    Alena Grabowski; Fiscal Year: 2012
    ..This research will improve advanced leg prostheses for walking and running;thus facilitating the reintegration of Veterans with amputations into all facets of civilian life. ..
  10. Development of a Wearable Passive Vibration Therapy System for the Lower Extremit
    JEFFREY MICHAEL LEISMER; Fiscal Year: 2010
    ..the development and preclinical testing of a Wearable Passive Vibration Therapy (WPVT) System for the Lower Extremity for use by older adults with limited or no mobility...
  11. Community Ambulation Following Hip Fracture
    Jay Magaziner; Fiscal Year: 2013
    ..Other endpoints include precursors (i.e., endurance, balance, muscle performance, and lower extremity function) and selected underlying mechanisms (i.e...
  12. Improve Wound Healing with HIF-CA5 DNA Vector and Electroporation
    John W Harmon; Fiscal Year: 2010
    ..These non-healing ulcerations on the foot are disabling, and their progression leads to amputation of the lower extremity. Diabetes is the most frequent cause for lower extremity amputation in the United States...
  13. Improving ambulatory community access after paralysis
    Rudi Kobetic; Fiscal Year: 2012
    ..to correct gait instability and increase walking speed to improve ambulatory community access of persons with lower extremity paralysis due to incomplete spinal cord injury (ISCI)...
  14. Acupuncture for Aromatase Inhibitor-Related Arthralgias in Breast Cancer Patients
    Dawn Hershman; Fiscal Year: 2013
    ..3) analgesic use, 4) functional testing (grip strength and [unreadable]timed get up and go[unreadable] for lower extremity[unreadable]) and 5) exploratory inflammatory biomarkers and urine markers for AI adherence...
  15. Axonal Transport Deficits during Hereditary Spastic Paraplegia
    GERARDO ANDRES MORFINI; Fiscal Year: 2013
    ..The ultimate goal of this project is to define disease mechanisms and identify novel therapeutic targets in HSP. ..
  16. Dietary Nitrate to Augment Exercise Training Benefits in DM+PAD
    Jason David Allen; Fiscal Year: 2013
    ..DM+PAD patients are at increased risk for disease progression to critical leg ischemia, lower extremity amputation, and cardiovascular events...
  17. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    CHRISTOPHER GORDON THANOS; Fiscal Year: 2011
    ....
  18. Development of Cytokine-Inhibiting Gels for Treating Chronic Wounds
    Newell R Washburn; Fiscal Year: 2010
    ..Diabetic foot ulcers cost tens of thousands of dollars to treat and are the leading cause of lower extremity amputation...
  19. A new experimental model of knee joint trauma
    TAMMY L HAUTDONAHUE; Fiscal Year: 2012
    ....
  20. Effect of botulinum toxin plus vibration on bone in children with cerebral palsy
    Christopher M Modlesky; Fiscal Year: 2012
    ..published studies indicate that a daily HLV stimulus can increase BMC and improve bone structure in the lower extremity bones of children with CP...
  21. Modulated Imaging in Comprehensive Assessment of Diabetic Foot Ulcer Development
    Amaan Mazhar; Fiscal Year: 2012
    ..In fact, roughly 85% of all lower extremity amputations in patients with diabetes mellitus are preceded by a foot ulcer...
  22. Development of Extracellular Heat Shock Protein-90 as a Novel Topical Wound Heali
    Wei Li; Fiscal Year: 2013
    ..For example, the number of lower extremity amputations is approaching 100,000 in the US due to non-healing diabetic ulcers, in which a single surgical ..
  23. Comparative Effectiveness of Customary Fit and Strong! vs. Fit and Strong! Plus
    Susan L Hughes; Fiscal Year: 2013
    ..OA is the primary cause of disability among older adults (Hootman et al., 2009), and lower extremity (LE) OA is the pathway through which this disability develops (Dunlop, Hughes, et al., 1998)...
  24. Skin Temperature Perception and Prosthetic Thermoregulation
    GLENN KLUTE; Fiscal Year: 2012
    ..We believe that the knowledge disseminated from this research will lead to substantial improvements in the quality of life of Veteran amputees. ..
  25. Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
    KRISTA H VANDENBORNE; Fiscal Year: 2013
    ..study will examine the intramuscular lipid content, muscle damage/inflammation and contractile area in the lower extremity muscles of 100 ambulatory boys with DMD and 50 healthy age matched boys using a combination of MRI and MRS ..
  26. Cell-synthesized Thread-based Tissue Engineering
    NICOLAS L'HEUREUX; Fiscal Year: 2012
    ....
  27. Sex-specific genetic architecture of irritable bowel syndrome
    Lisa A Kilpatrick; Fiscal Year: 2013
    ..Such differences have important implications for tailoring treatments to individuals and are expected to stimulate the field of personalized medicine. ..
  28. Tai Chi after Pulmonary Rehabilitation in Patients with COPD: A Randomized Trial
    Gloria Y Yeh; Fiscal Year: 2013
    ..tai chi exercise comprehensively integrates several key elements of PR (aerobic exercise, upper and lower extremity training, breathing, and stress management) into one relatively low-cost and accessible activity...
  29. 2012 AAOS Femoroacetabular Impingement Research Symposium
    John C Clohisy; Fiscal Year: 2011
    ..b>Lower extremity OA is particularly common and costly. Estimates show that by 2030, over 4...
  30. Micro-RNA Molecules as Regulators of Diabetic Wound Healing
    Marjana Tomic-Canic; Fiscal Year: 2013
    ..Diabetic foot ulcers (DFUs) are one of the major complications of diabetes mellitus leadin to lower extremity amputation for thousands of diabetic persons each year...
  31. Discontinuing NSAIDs in Veterans with Knee Osteoarthritis
    Liana Fraenkel; Fiscal Year: 2013
    ..We will also test for between group differences in lower extremity disability, subjects'global impression of change and use of co- therapies (secondary outcomes)...
  32. MASP-2 Antibodies for Diabetic Neuropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2012
    ..with long term diabetes and accounts for significant morbidity by predisposing the foot to ulceration and lower extremity amputation. A progressive loss of peripheral nerve function is the underlying cause...
  33. Musculoskeletal Biomechanics of Gradient Walking in Obese Adults
    RAYMOND CLIFTON BROWNING; Fiscal Year: 2012
    ..long term goal of this research is to derive walking exercise prescriptions for obese adults that minimize lower extremity biomechanical loads while optimizing caloric expenditure and cardiovascular stimulus...
  34. OSTEOGENIC REGULATION OF VASCULAR CALCIFICATION
    Dwight A Towler; Fiscal Year: 2012
    ..In patients with type II diabetes (T2DM), medial artery calcification is a powerful index of lower extremity amputation risk;arteriosclerotic medial calcification is a much more ominous predictor of amputation than ..
  35. Role of Femoral Atherosclerosis in Functional Status, CVD Events, and Mortality
    CHRISTINA LYNN WASSEL; Fiscal Year: 2013
    ..90 indicates PAD;however, by this time usually hemodynamically significant fixed stenotic lesions exist in lower extremity arteries...
  36. Ambulatory Case and Preventable Hospitalizations in Diabetic Kidney Disease
    Chin Lin Tseng; Fiscal Year: 2013
    ..Composite PQIs include metabolic decompensation, lower extremity amputations/ulcers, cardiovascular events, and infections (pneumonia and urinary tract infection)...
  37. STIMULATION-AUGMENTED EXERCISE AND NEUROMOTOR THERAPY
    Eric C Hartman; Fiscal Year: 2010
    ..The device will provide a closed-chain, load bearing lower extremity exercise that has the potential to condition muscles and reverse or slow the rate of loss of bone mineral ..
  38. Sex-specific movement differences in young adults with and without hip pain
    CARA L LEWIS; Fiscal Year: 2013
    ..of the structural abnormalities among females and males, and because a sex effect has been noted in other lower extremity injuries (e.g. ACL tears, patellofemoral pain)...
  39. Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous Insufficiency
    Raouf A Khalil; Fiscal Year: 2013
    ..CVI commonly occurs in the lower extremity, suggesting a role of venous pressure and vein wall stretch...
  40. Nitric Oxide-Releasing Wound Dressing for Preventing Chronic Wound Infections
    NATHAN ALLAN STASKO; Fiscal Year: 2012
    ..The Company has assembled a strong team of scientists, clinicians, contractors, and business leaders who believe in the technology and are positioned to ensure the greatest likelihood for success. ..
  41. Effect of Prosthetic Foot-Ankle Stiffness on Amputee Function
    GLENN KLUTE; Fiscal Year: 2011
    ..We believe that the knowledge disseminated from this research will lead to a substantial improvement of the health, independence, employment, recreation, and quality of life of Veteran lower limb amputees. ..
  42. Epidemiology of Patellofemoral Pain Syndrome: Identifying Gender Specific Risk Fa
    MICHELLE CLARA BOLING; Fiscal Year: 2011
    ..The central hypothesis is that individuals who develop PFP will have altered movement patterns, abnormal lower extremity anatomical alignments, decreased lower extremity strength, previous history of knee injury, previous ..
  43. Effect of Intense Multi-Modal Training on Bone Mineral Density, Bone Biomarkers,
    Todd Anthony Astorino; Fiscal Year: 2013
    ..They will complete 6 - 9 hours per week of intense multi-modal rehabilitation focusing on lower extremity loading. Their responses will be compared to five adults with SCI who do not complete this mode of exercise...
  44. Concurrent Upper/Lower Extremity SCI Exercise with Stimulation
    LEE BARNETT; Fiscal Year: 2010
    ..DESCRIPTION (provided by applicant): This proposal will develop a FES-augmented recumbent stepper that elicits lower extremity involvement through electrical stimulation while upper extremity involvement is volitionally controlled by ..
  45. Multivalent Conjugates of Sonic Hedgehog to Accelerate Diabetic Wound Healing
    WESLEY MICHAEL JACKSON; Fiscal Year: 2012
    DESCRIPTION: In 2010, more than 875,000 Americans with diabetes were diagnosed with a lower extremity ulcer. Failed closure of these wounds results in more than 73,500 lower extremity amputations annually. Valitor, Inc...
  46. Development of the Cellular Biomarker for Diabetic Foot Ulcers
    MARJANA contact TOMIC CANIC; Fiscal Year: 2010
    ....
  47. Mechanisms of Hand Dysfunction following Hemodialysis Fistula Creation
    Salvatore T Scali; Fiscal Year: 2013
    ..in the overall management of limb dysfunction that can potentially be extrapolated more broadly to alternative disease states (muscular dystrophy, lower extremity peripheral arterial occlusive disease, and post- surgical trauma).
  48. PHASE-BASED CONTROL OF LOCOMOTION FOR HIGH-PERFORMANCE PROSTHESES AND ORTHOSES
    Robert D Gregg; Fiscal Year: 2013
    ..My expertise in robot control and postdoctoral training in prosthetics make me uniquely qualified to successfully execute this highly innovative work. ..
  49. Cortical Control of Hindlimb Muscles in Primates
    PAUL DAVID CHENEY; Fiscal Year: 2012
    ..and the subject of a large number of studies, comparatively little is known about the cortical control of the lower extremity despite its obvious importance both clinically and in the motor repertoire of primates including humans...
  50. Muscle Weakness and Post-Traumatic Knee OA
    Terese L Chmielewski; Fiscal Year: 2011
    ..The Secondary Aim is to examine the association of post-meniscectomy quadriceps strength deficits with lower extremity loading symmetry and the extent of knee inflammation...
  51. Development of an Atmospheric Plasma Applicator to Treat Chronic Wounds
    Kimberly Kelly-Wintenberg; Fiscal Year: 2011
    ..by applicant): Annually, 5 to 7 million Americans are treated for chronic wounds that arise from diabetes, lower extremity arterial disease, lower extremity venous disease and edema, and pressure ulcers, and traumatic injuries, ..
  52. Developing a brain-machine interface for an ankle robot
    Larry Forrester; Fiscal Year: 2012
    ..Recently we also have shown the first use of noninvasive (EEG) to decode and reconstruct lower extremity joint kinematics for treadmill walking in nondisabled subjects...
  53. Clinical Research Center to Decrease Limb Amputation Rate in People with Diabetes
    Harold Brem; Fiscal Year: 2013
    ....
  54. Comparative Effectiveness of Adjunctive Devices For the Previous
    David J Margolis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lower extremity amputation (LEA) is a very severe and catastrophic complication of diabetes mellitus...
  55. Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) Trial
    ERIN ELIZABETH KREBS; Fiscal Year: 2013
    ..05 and 20% attrition. Analysis will use an intent-to-treat approach, including all participants in the arm to which they were originally assigned. ..
  56. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2013
    ..Arteriosclerosis- viz., medial calcific sclerosis - has emerged as a particularly important contributor to lower extremity (LE) amputation risk in type II diabetes (T2DM)...
  57. A Virtually Supervised Web-Based Home Exercise Technology for Older Adults
    Bijan Najafi; Fiscal Year: 2013
    ..In the first of two clinical studies we will evaluate the accuracy of the estimates of lower extremity kinematics during exercise provided by the new system...
  58. Novel Biological Tissue Lined Vascular Stent Crimping and Delivery System
    MICHAEL JOHN WIGGINS; Fiscal Year: 2010
    ..Of the arteries in the lower extremity, the superficial femoral artery (SFA) is the most commonly affected by PAD with over 50% of all PAD involving ..
  59. Promoting "Stories of Success": Enhancing Diabetes Self-Care
    Ishan Canty Williams; Fiscal Year: 2010
    ..This new approach to diabetes education will be delivered to groups and individuals to determine which way is best accepted and has the best results. ..
  60. Clinical Trial Planning Grant in Catheter-Directed Thrombolysis of Occlusive DVT
    Marilyn J Manco-Johnson; Fiscal Year: 2013
    ..results from the applicants'institutional cohort of children from 9 to 20 years f age with proximal lower extremity DVT demonstrate that 92% were completely veno-occlusive with IVC involvement in 31% and IVC or iliac ..
  61. Promoting Physical Activity in Older Adults with Comorbidity
    ELIZABETH ANN SCHLENK; Fiscal Year: 2013
    ..Arthritis (STAR) intervention, guided by self-efficacy theory and modified to address comorbid HBP, affects lower extremity exercise (flexibility, strengthening, and balance), fitness walking, functional status, BP, quadriceps ..
  62. Resilience to Mobility Impairment: Neural Correlates and Protective Factors
    Caterina Rosano; Fiscal Year: 2013
    ..Results from this research project may shed light on the mechanisms underlying physical disability and may help us prepare prevention and intervention studies. ..
  63. ZeroG: Dynamic Over-Ground Body-Weight Support System
    Joseph Hidler; Fiscal Year: 2009
    ..2005). ..
  64. SCI SHOULDER FUNCTION IN ASSISTIVE DEVICE GAIT
    Jacquelin Perry; Fiscal Year: 2002
    ..A second purpose is to relate the identified demands to the patients' lesion level, pattern of upper and lower extremity muscle strength and orthotic support...
  65. CAD-CAM TECHNOLOGY FOR DIABETIC FOOTWEAR
    JOSEPH L LOOMIS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Diabetes remains the leading cause of non-traumatic lower extremity amputations...
  66. A Low-Cost Upper-Extremity Prosthesis for Under-Served Populations
    BRADLEY VEATCH; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  67. Anatomic Risk Factors for Venous Thromboembolism
    ANAND KUMAR NARAYAN; Fiscal Year: 2010
    Deep venous thrombosis (DVT) of the lower extremity is one of the major causes of morbidity and mortality in hospital based patients...
  68. SYMPOSIUM ON HEREDITARY SPASTIC PARAPLEGIA
    John Fink; Fiscal Year: 1999
    Hereditary Spastic Paraplegia (HSP) is a group of disorders characterized by progressive lower extremity spastic weakness...
  69. DIABETIC NEUROPATHIC FOOT ULCER: WHO WILL HEAL?
    David Margolis; Fiscal Year: 2003
    DESCRIPTION (adapted from the application) Lower extremity ulcers are a serious complication of diabetes mellitus...
  70. Clinical Implications of Peripheral Plaque Morphology
    Daniel Clair; Fiscal Year: 2007
    ..We propose similar studies in the peripheral arterial bed, quantifying the amount and composition of lower extremity arterial atheroma and relating these findings to the patients' clinical presentation and subsequent ..
  71. Influence of Ankle Motion on Bilateral Amputee Gait
    Steven Gard; Fiscal Year: 2004
    ..The results from this study will aid in identifying limitations in current prosthetic technology that inhibit normal patterns of walking in amputees. ..
  72. ActiveImplant Prosthesis for Lower Limb Amputees
    JOHN FAGO; Fiscal Year: 2007
    ..Increased mobility will come in the form of improved gait speed, increased stability, and reduced energy expenditure, which will also lead to an improved productivity and quality of life. [unreadable] [unreadable]..
  73. HEREDITARY SPASTIC PARAPLEGIA--CLINICAL, HISTOCHEMICAL,
    John Fink; Fiscal Year: 2001
    Hereditary Spastic Paraplegia (HSP) refers to a group of disorders characterized by progressive lower extremity spastic weakness...
  74. KNEE STABILITY TRAINING IN INDIVDUALS WITH KNEE OSTEOARTHRITIS
    G Fitzgerald; Fiscal Year: 2007
    Traditional exercise therapy programs for knee osteoarthritis (OA) primarily focus on addressing lower extremity strength and joint motion deficits and have yielded fair to moderate improvements in functional status...
  75. Hereditary Spastic Paraplegia due to SPG3A/atlastin mutation
    John Fink; Fiscal Year: 2009
    ..The Hereditary Spastic Paraplegias (HSPs) are degenerative spinal cord disorders that cause disabling lower extremity spastic weakness...
  76. Controlled Release Vascular Grafts
    ANTONIO WEBB; Fiscal Year: 2009
    ..For those with severe PAD, lower extremity bypass grafting remains the predominant option for limb salvage...
  77. Symmetrical walking enhanced neuroplasticity post-stroke
    JAMES STINEAR; Fiscal Year: 2009
    ..These gains would enhance stroke survivor's physical and social well being. ..
  78. HUMAN RESPONSE AND LOWER EXTREMITY INJURY
    CLAYTON MOTE; Fiscal Year: 1991
    The mechanics of injury to the human knee is a complex process where external forces are transmitted to the lower extremity, the lower extremity responds causing displacements and rotations across the knee, stresses are induced in the ..
  79. Metabolic MRI of Diabetic Lower Extremity Disease
    Robert L Greenman; Fiscal Year: 2010
    Fifty nine percent of diabetic patients in the United States have lower extremity complications...
  80. COMPUTER-WORKSTATION/NETWORK-SERVER TO LINK NIH INVESTIG
    WILLIAM RYMER; Fiscal Year: 1992
    ....
  81. Real-time Gait Retraining to Reduce Loading in Runners
    Irene Davis; Fiscal Year: 2009
    ..determine which kinematic strategies are used to reduce lower extremity loading;3...
  82. Medial Collapse Movement Impairments associated with Patellofemoral Pain
    GRETCHEN SALSICH; Fiscal Year: 2009
    ..to increased patellofemoral joint stress is a movement impairment consisting of medial collapse of the lower extremity during weightbearing...