extremities

Summary

Top Publications

  1. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
  2. pmc Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip
    Yuval Rinkevich
    Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305 5323, USA
    Nature 476:409-13. 2011
  3. ncbi Cells keep a memory of their tissue origin during axolotl limb regeneration
    Martin Kragl
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108
    Nature 460:60-5. 2009
  4. pmc Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    Amitabha Bandyopadhyay
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e216. 2006
  5. pmc A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
    Steven A Vokes
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 22:2651-63. 2008
  6. ncbi Normal newt limb regeneration requires matrix metalloproteinase function
    Vladimir Vinarsky
    Division of Cardiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Dev Biol 279:86-98. 2005
  7. pmc Wnt/beta-catenin signaling regulates vertebrate limb regeneration
    Yasuhiko Kawakami
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 20:3232-7. 2006
  8. pmc Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb
    Carlos I Lorda-Diez
    Departamento de Anatomía y Biología Celular and Instituto de Formación e Investigación Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain
    PLoS ONE 6:e24546. 2011
  9. pmc Regeneration review reprise
    Jessica L Whited
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 360, Boston, MA 02115, USA
    J Biol 9:15. 2010
  10. ncbi Amphibian limb regeneration: rebuilding a complex structure
    J P Brockes
    Ludwig Institute for Cancer Research and Department of Biochemistry and Molecular Biology, University College London, 91 Riding House Street, London W1P 8BT, UK
    Science 276:81-7. 1997

Detail Information

Publications340 found, 100 shown here

  1. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
    ..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient...
  2. pmc Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip
    Yuval Rinkevich
    Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305 5323, USA
    Nature 476:409-13. 2011
    ....
  3. ncbi Cells keep a memory of their tissue origin during axolotl limb regeneration
    Martin Kragl
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108
    Nature 460:60-5. 2009
    ..Our results show that the complex phenomenon of limb regeneration can be achieved without complete dedifferentiation to a pluripotent state, a conclusion with important implications for regenerative medicine...
  4. pmc Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    Amitabha Bandyopadhyay
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e216. 2006
    ..In contrast, we find that the loss of both BMP2 and BMP4 results in a severe impairment of osteogenesis...
  5. pmc A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
    Steven A Vokes
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 22:2651-63. 2008
    ..These studies provide the first comprehensive characterization of the transcriptional output of a Shh-patterning process in the mammalian embryo and a framework for elaborating regulatory networks in the developing limb...
  6. ncbi Normal newt limb regeneration requires matrix metalloproteinase function
    Vladimir Vinarsky
    Division of Cardiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Dev Biol 279:86-98. 2005
    ..These data suggest that MMPs are required for normal newt limb regeneration and that MMPs function, in part, to prevent scar formation during the regenerative process...
  7. pmc Wnt/beta-catenin signaling regulates vertebrate limb regeneration
    Yasuhiko Kawakami
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 20:3232-7. 2006
    ..Our studies may provide valuable insights toward a better understanding of adult tissue regeneration...
  8. pmc Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb
    Carlos I Lorda-Diez
    Departamento de Anatomía y Biología Celular and Instituto de Formación e Investigación Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain
    PLoS ONE 6:e24546. 2011
    ....
  9. pmc Regeneration review reprise
    Jessica L Whited
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 360, Boston, MA 02115, USA
    J Biol 9:15. 2010
    ..Increasingly, progress in the regeneration field is being inspired by comparisons with stem cell biology and enabled by newly developed techniques that allow simultaneous examination of thousands of genes and proteins...
  10. ncbi Amphibian limb regeneration: rebuilding a complex structure
    J P Brockes
    Ludwig Institute for Cancer Research and Department of Biochemistry and Molecular Biology, University College London, 91 Riding House Street, London W1P 8BT, UK
    Science 276:81-7. 1997
    ..The possibility of inducing a blastema on a mammalian limb cannot be discounted, although the molecular constraints are becoming clearer as we understand more about the mechanisms of urodele regeneration...
  11. ncbi Amphibian regeneration and stem cells
    D L Stocum
    Department of Biology, Indiana University Center for Regenerative Biology and Medicine, School of Science, Indiana University Purdue University Indianapolis, 402 N Blackford St, Indianapolis, IN 46202, USA
    Curr Top Microbiol Immunol 280:1-70. 2004
    ....
  12. pmc Mouse digit tip regeneration is mediated by fate-restricted progenitor cells
    Jessica A Lehoczky
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:20609-14. 2011
    ....
  13. pmc BMP signaling induces digit regeneration in neonatal mice
    Ling Yu
    Division of Developmental Biology, Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Development 137:551-9. 2010
    ..These studies demonstrate for the first time that the postnatal mammalian digit has latent regenerative capabilities that can be induced by growth factor treatment...
  14. ncbi Plasticity and reprogramming of differentiated cells in amphibian regeneration
    Jeremy P Brockes
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Mol Cell Biol 3:566-74. 2002
    ..The recent demonstrations of plasticity in mouse myotubes should facilitate comparative studies of the pathways that underlie the regenerative response, as well as proposing new approaches to promote mammalian regeneration...
  15. ncbi Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud
    Jianjian Zhu
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Dev Cell 14:624-32. 2008
    ..The progressive loss of digits upon successively earlier Shh removal mirrors this alternating sequence and highlights Shh's role in cell expansion to produce the normal digit complement...
  16. ncbi Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity
    J C Yang
    Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Clin Oncol 16:197-203. 1998
    ..This randomized, prospective study assesses the impact of postoperative external-beam radiation therapy on local recurrence (LR), overall survival (OS), and quality of life after limb-sparing resection of extremity sarcomas...
  17. ncbi Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
    L J Brunet
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720 3204, USA
    Science 280:1455-7. 1998
    ..Excess BMP activity in the absence of Noggin antagonism may enhance the recruitment of cells into cartilage, resulting in oversized growth plates; chondrocytes are also refractory to joint-inducing positional cues...
  18. ncbi High grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions
    Gaetano Bacci
    Chemotherapy, Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Surg Oncol 98:415-20. 2008
    ..Between 1986 and 2001, 162 patients with extremity osteosarcoma and lung metastases at presentation, were treated by neoadjuvant chemotherapy, simultaneous resection of primary and, when feasible, secondary lesions followed by chemotherapy...
  19. ncbi Vertebrate limb regeneration and the origin of limb stem cells
    Susan V Bryant
    Developmental Biology Center and Department of Developmental and Cell Biology, University of California, Irvine 92697 2275, USA
    Int J Dev Biol 46:887-96. 2002
    ..Advances in regeneration research will then feed back in terms of devising new strategies for therapies to induce regeneration in organisms such as humans that have traditionally been viewed as incapable of regeneration...
  20. ncbi Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization
    Kaoru Tateno
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Japan
    Circ Res 98:1194-202. 2006
    ..Further studies will allow us to develop more effective treatments for ischemic vascular disease...
  21. ncbi Growing models of vertebrate limb development
    Matthew Towers
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Development 136:179-90. 2009
    ..In this review, we discuss these recent findings and propose how the various models of limb patterning can be reconciled...
  22. pmc ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression
    Daniel R McCulloch
    Department of Biomedical Engineering, Lerner Research Institute, ND20 Cleveland Clinic, Cleveland, OH 44195, USA
    Dev Cell 17:687-98. 2009
    ..The data highlight the developmental significance of proteolytic action on the ECM, not only as a clearance mechanism, but also as a means to generate bioactive versican fragments...
  23. ncbi Right insula for our sense of limb ownership and self-awareness of actions
    Hans Otto Karnath
    Section of Neuropsychology, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Brain Struct Funct 214:411-7. 2010
    ..We thus hypothesize that the right insular cortex constitutes a central node of a network involved in human body scheme representation...
  24. ncbi Rates and patterns in the evolution of snake-like body form in squamate reptiles: evidence for repeated re-evolution of lost digits and long-term persistence of intermediate body forms
    Matthew C Brandley
    Museum of Vertebrate Zoology, University of California, Berkeley, California 94270, USA
    Evolution 62:2042-64. 2008
    ..Finally, although loss of digits is common, we find statistically significant support for at least six examples of the re-evolution of lost digits in the forelimb and hind limb...
  25. ncbi Mechanisms of digit formation: Human malformation syndromes tell the story
    Sigmar Stricker
    Development and Disease Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Dev Dyn 240:990-1004. 2011
    ..Developmental Dynamics 240:990-1004, 2011. © 2011 Wiley-Liss, Inc...
  26. ncbi Multipotent vasculogenic pericytes from human pluripotent stem cells promote recovery of murine ischemic limb
    Ayelet Dar
    Department of Ob Gyn, Rambam Health Care Campus, Haifa 31096, Israel
    Circulation 125:87-99. 2012
    ....
  27. ncbi Blastema induction in aneurogenic state and Prrx-1 regulation by MMPs and FGFs in Ambystoma mexicanum limb regeneration
    Akira Satoh
    Okayama University, Research Core for Interdisciplinary Sciences RCIS, 3 1 1, Tsushimanaka, Kitaku, Okayama, 700 8530, Japan
    Dev Biol 355:263-74. 2011
    ..Furthermore, we demonstrated that these two activities were sufficient to induce an ALM blastema in the absence of a nerve in vivo...
  28. pmc Establishment of medial fates along the proximodistal axis of the Drosophila leg through direct activation of dachshund by Distalless
    Matt W Giorgianni
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Dev Cell 20:455-68. 2011
    ..Thus, medial leg fates are established via a regulatory cascade in which Wg+Dpp activate Dll and then Dll directly activates dac, with Wg+Dpp as less critical, permissive inputs...
  29. pmc A computational analysis of limb and body dimensions in Tyrannosaurus rex with implications for locomotion, ontogeny, and growth
    John R Hutchinson
    Structure and Motion Laboratory, Department of Veterinary Basic Sciences, The Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom
    PLoS ONE 6:e26037. 2011
    ..Overall, the limb "antigravity" muscles may have been as large as or even larger than those of ratite birds, which themselves have the most muscular limbs of any living animal...
  30. ncbi Stick insect locomotion in a complex environment: climbing over large gaps
    Bettina Blaesing
    Faculty of Biology, University of Bielefeld, Postbox 100131, D 33501 Bielefeld, Germany
    J Exp Biol 207:1273-86. 2004
    ..Comparing flow charts for two gap sizes revealed differences in the frequency and succession of these elements, especially during the first part of the sequence...
  31. ncbi A BMP-Shh negative-feedback loop restricts Shh expression during limb development
    Ma Félix Bastida
    Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria, Santander, Spain
    Development 136:3779-89. 2009
    ..Our study emphasizes the intricacy of the crosstalk between the major signaling pathways in the posterior limb bud...
  32. pmc Limb bone allometry during postnatal ontogeny in non-avian dinosaurs
    Brandon M Kilbourne
    Department of Geology, Field Museum of Natural History, Chicago, IL 60605, USA
    J Anat 217:135-52. 2010
    ..The intraspecific scaling patterns observed in dinosaurs and other amniotes do not support earlier hypotheses that intraspecific scaling differs between endothermic and ectothermic taxa...
  33. ncbi In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth
    Danielle M Maatouk
    Department of Molecular Genetics and Microbiology and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32611, USA
    Dev Biol 327:516-23. 2009
    ..Our data suggests that AER expression of Bmp2 and Bmp4 is required for digit and dorsal-ventral patterning but surprisingly not for limb outgrowth...
  34. ncbi Sizing the Jurassic theropod dinosaur Allosaurus: assessing growth strategy and evolution of ontogenetic scaling of limbs
    Paul J Bybee
    Department of Earth Science, Utah Valley State College, Orem, 84058 5999, USA
    J Morphol 267:347-59. 2006
    ..Phylogenetic optimization suggests that large theropods independently evolved reduced humeral, ulnar, and tibial lengths by a phyletic reduction in longitudinal growth relative to the femur...
  35. ncbi Pattern formation in the limbs of Drosophila: bric à brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus
    D Godt
    Department of Biology, University of California at Los Angeles 90024
    Development 119:799-812. 1993
    ..The graded requirement for bric à brac correlates with its graded expression pattern, suggesting that the concentration of BRIC A BRAC protein specifies segment identity in the tarsus...
  36. ncbi Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    Y Echelard
    Harvard University, Department of Biochemistry, Molecular Biology, and Cellular and Developmental Biology, Cambridge, Massachusetts 02138
    Cell 75:1417-30. 1993
    ..Ectopic expression of Shh in the mouse CNS leads to the activation of floor plate-expressed genes. These results suggest that Shh may play a role in the normal inductive interactions that pattern the ventral CNS...
  37. ncbi Prognostic factors in localized extremity osteosarcoma: a systematic review
    J A M Bramer
    Department of Orthopedic Surgery G4 221, Academic Medical Center, Meibergdreef 9, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Eur J Surg Oncol 35:1030-6. 2009
    ..showed chemotherapy response as only independent factor. We tried to identify evidence-based prognostic factors in the literature since 1992 and to establish pooled relative risks of factors...
  38. ncbi Functional analysis of CTCF during mammalian limb development
    Natalia Soshnikova
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Dev Cell 19:819-30. 2010
    ..We conclude that, at least in this physiological context, rather than being an insulator, CTCF is required for cell survival via the direct transcriptional regulation of target genes critical for cellular homeostasis...
  39. ncbi Fins to limbs: what the fossils say
    Michael I Coates
    Department of Organismal Biology and Anatomy, University of Chicago, IL 60637, USA
    Evol Dev 4:390-401. 2002
    ..This reduction in segment number is accompanied by increased regional specialization, and these changes are discussed with reference to the phylogenetic distribution of characteristics of the stylopod, zeugopod, and autopod...
  40. pmc Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioning
    C Ren
    Department of Neurosurgery, Stanford University School of Medicine, MSLS Building, P306, 1201 Welch Road, Room P306, Stanford, CA 94305 5327, USA
    Neuroscience 151:1099-103. 2008
    ..In conclusion, remote preconditioning performed in one limb protected against ischemic damage after focal cerebral ischemia...
  41. ncbi The role of CYP26 enzymes in defining appropriate retinoic acid exposure during embryogenesis
    Tracie Pennimpede
    Department of Pathology and Molecular Medicine, Cancer Research Institute, Division of Cancer Biology and Genetics, Queen s University, Kingston, Ontario, Canada
    Birth Defects Res A Clin Mol Teratol 88:883-94. 2010
    ....
  42. ncbi The acquisition of motoneuron subtype identity and motor circuit formation
    L T Landmesser
    Department of Neurosciences, Case Western Reserve University, School of Medicine, 10900 Euclid Ave, Cleveland, OH 44106 4975, USA
    Int J Dev Neurosci 19:175-82. 2001
    ..These observations are then related to the combinatorial code of LIM transcription factor expression, which has been hypothesized to specify motoneuron subtypes...
  43. ncbi Expression and biological effect of urodele fibroblast growth factor 1: relationship to limb regeneration
    Kathleen M Dungan
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    J Exp Zool 292:540-54. 2002
    ....
  44. pmc Differential recruitment of limb patterning genes during development and diversification of beetle horns
    Armin P Moczek
    Department of Biology, Indiana University, 915 East Third Street, Myers Hall 150, Bloomington, IN 47405 7107, USA
    Proc Natl Acad Sci U S A 106:8992-7. 2009
    ....
  45. pmc Genetically regulated epigenetic transcriptional activation of retrotransposon insertion confers mouse dactylaplasia phenotype
    Hiroki Kano
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 104:19034-9. 2007
    ..Our findings indicate that ectopic expression from the MusD insertion correlates with the dactylaplasia phenotype and that Mdac acts as a defensive factor to protect the host genome from pathogenic MusD insertions...
  46. ncbi Lateralization of ventral fins use during object exploration in the blue gourami (Trichogaster trichopterus)
    A Bisazza
    Department of General Psychology, University of Padova, Via Venezia 8, 35131, Padua, Italy
    Physiol Behav 72:575-8. 2001
    ....
  47. pmc LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth
    Itai Tzchori
    Section on Mammalian Molecular Genetics, Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Development 136:1375-85. 2009
    ....
  48. ncbi IGF signaling between blastema and wound epidermis is required for fin regeneration
    Fabian Chablais
    Unit of Anatomy, Department of Medicine, University of Fribourg, Rte A Gockel 1, CH 1700 Fribourg, Switzerland
    Development 137:871-9. 2010
    ..Thus, IGF signaling upregulated upon fin amputation represents a signal from the blastema to the wound epithelium, a crucial step in appendage regeneration...
  49. pmc Global control of motor neuron topography mediated by the repressive actions of a single hox gene
    Heekyung Jung
    Howard Hughes Medical Institute, Smilow Neuroscience Program, Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016, USA
    Neuron 67:781-96. 2010
    ..Genome-wide analysis of Hoxc9 binding suggests that this mode of repression is mediated by direct interactions with Hox regulatory elements, independent of chromatin marks typically associated with repressed Hox genes...
  50. ncbi Tetrapod trackways from the early Middle Devonian period of Poland
    Grzegorz Niedzwiedzki
    Department of Paleobiology and Evolution, Faculty of Biology, Warsaw University, 2S Banacha Street, 02 097 Warsaw, Poland
    Nature 463:43-8. 2010
    ..They force a radical reassessment of the timing, ecology and environmental setting of the fish-tetrapod transition, as well as the completeness of the body fossil record...
  51. ncbi Comparative aspects of animal regeneration
    Jeremy P Brockes
    Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, England
    Annu Rev Cell Dev Biol 24:525-49. 2008
    ..These mechanisms are reviewed here across a range of contexts. We also consider the evolutionary origins of regeneration and how regeneration may relate to both agametic reproduction and to ontogeny...
  52. ncbi One-sided limb preference is linked to alternating-limb locomotion in anuran amphibians
    Yegor B Malashichev
    Department of Vertebrate Zoology, Faculty of Biology and Soil Sciences, St Petersburg State University, St Petersburg, Russia
    J Comp Psychol 120:401-10. 2006
    ..Conclusions reached for anuran amphibians may be applicable to other vertebrates possessing paired appendages-the degree of lateralization in motor response depends on the mode of locomotion used by a species...
  53. ncbi Evidence that mechanisms of fin development evolved in the midline of early vertebrates
    Renata Freitas
    Department of Zoology, University of Florida, PO Box 118525, Gainesville, Florida 32611, USA
    Nature 442:1033-7. 2006
    ....
  54. ncbi The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila
    Jean Louis Couderc
    INSERM UMR 384, Laboratoire de Biochimie, 28 Place Henri Dunant, 63001 Clermont Ferrand, Cedex, France
    Development 129:2419-33. 2002
    ....
  55. ncbi A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration
    Alex Nechiporuk
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Development 129:2607-17. 2002
    ....
  56. ncbi Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia
    John Cobb
    National Research Center NCCR Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Development 132:3055-67. 2005
    ..e. the digits and the penis/clitoris...
  57. ncbi Loss of the Tg737 protein results in skeletal patterning defects
    Qihong Zhang
    The University of Alabama at Birmingham, Department of Cell Biology, Birmingham, Alabama 35294, USA
    Dev Dyn 227:78-90. 2003
    ..Collectively, the data argue for a dosage effect of Tg737 on the limb phenotypes and that the polydactyly is independent of Shh misexpression...
  58. ncbi Molecular genetic cascades for external genitalia formation: an emerging organogenesis program
    G Yamada
    Center for Animal Resources and Development CARD, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Dev Dyn 235:1738-52. 2006
    ..Development of the male and female external genitalia is also reviewed...
  59. ncbi A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ
    Y Zhang
    Department of Cell and Molecular Biology, Molecular and Cell Biology Graduate Program, Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Development 127:1431-43. 2000
    ..Taken together, our data provide insight into a new regulatory mechanism for Shh expression, and suggest that this BMP4-mediated pathway in Shh regulation may have a general implication in vertebrate organogenesis...
  60. pmc Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Biol 331:270-80. 2009
    ..Thus, the fin wound epidermis spatially confines Hh signaling through the activity of Fgf and Wnt pathways, impacting blastemal proliferation during regenerative outgrowth...
  61. ncbi Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs
    Osamu Iba
    Department of Medicine II and Cardiovascular Center, Kansai Medical University, Moriguchi, Osaka, Japan
    Circulation 106:2019-25. 2002
    ..Peripheral blood mononuclear cells (PBMNCs), platelets, and polymorphonuclear leukocytes (PMNs) contain various angiogenic factors and cytokines...
  62. ncbi Appendage regeneration in adult vertebrates and implications for regenerative medicine
    Jeremy P Brockes
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 310:1919-23. 2005
    ..The blastema can regenerate autonomously as a self-organizing system over variable linear dimensions. Here we consider the prospects for limb regeneration in mammals from this viewpoint...
  63. pmc The formation of skeletal muscle: from somite to limb
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA 1947, Pasteur Institute, Paris, France
    J Anat 202:59-68. 2003
    ....
  64. ncbi Body integrity identity disorder: deranged body processing, right fronto-parietal dysfunction, and phenomenological experience of body incongruity
    Melita J Giummarra
    Experimental Neuropsychology Research Unit, School of Psychology and Psychiatry, Monash University, Wellington Road, Clayton, VIC 3800, Australia
    Neuropsychol Rev 21:320-33. 2011
    ....
  65. pmc BMP-2 functions independently of SHH signaling and triggers cell condensation and apoptosis in regenerating axolotl limbs
    Jean Charles Guimond
    Department of Stomatology, Faculty of Dentistry, Universite de Montreal, Montreal Qc Canada
    BMC Dev Biol 10:15. 2010
    ....
  66. ncbi Limb salvage with isolated perfusion for soft tissue sarcoma: could less TNF-alpha be better?
    S Bonvalot
    Department of Surgery, Institut Gustave Roussy, Villejuif, France
    Ann Oncol 16:1061-8. 2005
    ..The optimal dose of TNF-alpha delivered by isolated limb perfusion (ILP) in patients with locally advanced soft tissue sarcoma is still unknown...
  67. pmc Desmoid tumours of the extremities and trunk: a review of the literature
    Emilios E Pakos
    Department of Radiation Therapy, University Hospital of Ioannina, School of Medicine, University of Ioannina, Ioannina, Greece
    Int Orthop 29:210-3. 2005
    ..in the abdominal wall, the bowel, and the mesentery or in extra-abdominal sites such as the trunk and the extremities. Surgical resection is the main treatment modality in extremities and trunk, with the optional combination of ..
  68. ncbi The axolotl limb: a model for bone development, regeneration and fracture healing
    Cara Hutchison
    Department of Biochemistry, Universite de Montreal, Quebec, Canada
    Bone 40:45-56. 2007
    ..These results suggest that the axolotl does not use the regeneration process to repair bone fractures...
  69. pmc A comparative study of gland cells implicated in the nerve dependence of salamander limb regeneration
    Anoop Kumar
    Institute for Structural and Molecular Biology, University College London, London, UK
    J Anat 217:16-25. 2010
    ..These findings serve to unify the nerve dependence of limb regeneration...
  70. ncbi Visual targeting of forelimbs in ladder-walking locusts
    Jeremy E Niven
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Curr Biol 20:86-91. 2010
    ..The trajectory was only modified after missing the rung. Our data show that locusts walking in environments where footholds are limited use visual and mechanosensory information to place their front legs...
  71. pmc Anterior-posterior differences in HoxD chromatin topology in limb development
    Iain Williamson
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Development 139:3157-67. 2012
    ..This is the first example of A-P differences in chromatin compaction and chromatin looping in the development of the mammalian secondary body axis (limb)...
  72. pmc Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl
    Wei Zhu
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Dev Biol 370:42-51. 2012
    ..Given the requirement for FGF signaling in limb development and regeneration, the results suggest that PL1 and PL2 function to establish a unique germline-like state that is associated with successful regeneration...
  73. pmc Control of the spineless antennal enhancer: direct repression of antennal target genes by Antennapedia
    Dianne Duncan
    Department of Biology, Washington University, 1 Brookings Drive, St Louis, MO 63130, USA
    Dev Biol 347:82-91. 2010
    ..We conclude that the function of Antennapedia in the leg is not to repress homothorax, as has been suggested, but to directly repress spineless and other antennal genes that would otherwise be activated within this ring...
  74. ncbi Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities
    Margaret M Roebuck
    Department of Musculoskeletal Science, University of Liverpool, Liverpool, England
    Am J Clin Pathol 123:405-14. 2005
    ..The activation of endothelial MMP-2 linked to widespread MMP-14 expression provides a mechanism for sarcomas to modulate their matrix and facilitate angiogenesis...
  75. pmc Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning
    Xianling Zhao
    Development and Aging Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 19:1050-7. 2009
    ....
  76. ncbi Beneficial effects of VEGF secreted from stromal cells in supporting endothelial cell functions: therapeutic implications for critical limb ischemia
    Gilda Cobellis
    Dipartimento di Patologia Generale, Cattedra di Patologia Clinica, Seconda Universita degli Studi di Napoli, Napoli, Italy
    Cell Transplant 19:1425-37. 2010
    ....
  77. pmc Role of Epiprofin, a zinc-finger transcription factor, in limb development
    Ana Talamillo
    Departamento de Anatomía y Biología Celular Facultad de Medicina Universidad de Cantabria, 39011 Santander, Spain
    Dev Biol 337:363-74. 2010
    ....
  78. ncbi Goal-driven behavioral adaptations in gap-climbing Drosophila
    Simon Pick
    Lehrstuhl Genetik und Neurobiologie, Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    Curr Biol 15:1473-8. 2005
    ..The fact that the adaptations can be impaired separately unveils them as distinct subunits...
  79. pmc Limb-bone scaling indicates diverse stance and gait in quadrupedal ornithischian dinosaurs
    Susannah C R Maidment
    Department of Palaeontology, Natural History Museum, London, United Kingdom
    PLoS ONE 7:e36904. 2012
    ..For example, it has been proposed that some ornithischians could run, while others consider that none were cursorial...
  80. ncbi BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb
    S Pizette
    Molecular Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Development 128:4463-74. 2001
    ..We propose that the BMP signal bifurcates at the level of EN1 and MSX to mediate differentially DV patterning and AER induction, respectively...
  81. ncbi Clinical and social consequences of Buerger disease
    Takashi Ohta
    Department of Vascular Surgery, Aichi Medical University, 21 Karimata, Yazako, Nagakute, 480 1195 Aichi, Japan
    J Vasc Surg 39:176-80. 2004
    ..This study was undertaken to assess the clinical course of Buerger disease and to analyze the social problems that influence quality of life of affected patients...
  82. ncbi Deciphering skeletal patterning: clues from the limb
    Francesca V Mariani
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California 94143 0452, USA
    Nature 423:319-25. 2003
    ..Based on the data from such studies, models for how limb skeletal pattern is established have been proposed and continue to be hotly debated...
  83. pmc Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos
    Carlos I Lorda-Diez
    Departamento de Anatomia y Biologia Celular, Universidad de Cantabria IFIMAV, Santander 39011, Spain
    BMC Dev Biol 10:69. 2010
    ..Here we have studied in chicken embryos, whether these cytokines are implicated in the development of the embryonic limb bud at stages preceding tissue differentiation...
  84. ncbi Conserved mechanisms regulate outgrowth in zebrafish fins
    M Kathryn Iovine
    Lehigh University Department of Biological Sciences, 111 Research Drive, Iacocca B217, Bethlehem, Pennsylvania 18015, USA
    Nat Chem Biol 3:613-8. 2007
    ..Future perspectives describe opportunities using the zebrafish fin to reveal mechanisms underlying the regulation of final size...
  85. pmc Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities
    Yasuhiko Kawakami
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Development 136:585-94. 2009
    ....
  86. ncbi Opposing roles of two isoforms of the Prx1 homeobox gene in chondrogenesis
    Richard E Peterson
    Medical University of South Carolina, Department of Cell Biology and Anatomy, Charleston, South Carolina, USA
    Dev Dyn 233:811-21. 2005
    ..These results suggest that the Prx1a:Prx1b ratio and the alternative splicing mechanism that generates these two isoforms are critical in controlling chondrogenesis...
  87. pmc Co-option of an anteroposterior head axis patterning system for proximodistal patterning of appendages in early bilaterian evolution
    Derek Lemons
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
    Dev Biol 344:358-62. 2010
    ....
  88. ncbi Analysis of N-cadherin function in limb mesenchymal chondrogenesis in vitro
    Anthony M DeLise
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Dev Dyn 225:195-204. 2002
    ....
  89. ncbi Activator-inhibitor dynamics of vertebrate limb pattern formation
    Stuart A Newman
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Birth Defects Res C Embryo Today 81:305-19. 2007
    ..Finally, we discuss how viewing development as an interplay between molecular-genetic and dynamic physical processes can provide new insight into the origin of congenital anomalies...
  90. ncbi BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    E Minina
    Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Development 128:4523-34. 2001
    ..This role of BMP signaling is independent of the Ihh/PTHrP pathway...
  91. ncbi The molecular basis of amphibian limb regeneration: integrating the old with the new
    David M Gardiner
    Department of Developmental and Cell Biology, Developmental Biology Center, University of California Irvine, Irvine, CA 92697, USA
    Semin Cell Dev Biol 13:345-52. 2002
    ....
  92. ncbi Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution
    Gaetano Bacci
    Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Surg Oncol 96:118-23. 2007
    ..Indications and contraindications for limb salvage versus amputation for local treatment of osteosarcoma of the extremity are still controversial...
  93. ncbi A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant
    A Sidow
    Departments of Pathology and Genetics, SUMC R248B, Stanford, California 94305 5324, USA
    Nat Genet 23:104-7. 1999
    ..In conjuction with recent biochemical studies, this report demonstrates the importance of this gene family in vertebrate embryonic development...
  94. ncbi In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb
    Udayan Guha
    Department of Nueroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Dev Biol 249:108-20. 2002
    ..These abnormalities were rescued by coexpressing BMP4 under the same promoter in double transgenic mice, suggesting that the limb abnormalities are a direct effect of inhibiting BMP signaling...
  95. ncbi Cell proliferation and movement during early fin regeneration in zebrafish
    G Poleo
    Departments of Medicine and of Cellular and Molecular Medicine, Ottawa Health Research Institute at the Ottawa Hospital, University of Ottawa, Ottawa, Canada
    Dev Dyn 221:380-90. 2001
    ..Thus, cell proliferation and migration contribute to the early regeneration of zebrafish fins...
  96. ncbi Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    A Vortkamp
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 273:613-22. 1996
    ....
  97. ncbi Of fingers, toes and penises
    T Kondo
    Nature 390:29. 1997
  98. ncbi Pattern formation: old models out on a limb
    Lee Niswander
    Howard Hughes Medical Institute, Molecular Biology Programme, Sloan Kettering Institute, 1275 York Avenue, Box 73, New York, New York 10022, USA
    Nat Rev Genet 4:133-43. 2003
  99. ncbi The evolutionary continuum of limb function from early theropods to birds
    John R Hutchinson
    Structure and Motion Laboratory, Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Hatfield, Hertfordshire, AL9 7TA, UK
    Naturwissenschaften 96:423-48. 2009
    ....
  100. ncbi Bone morphogenetic protein signaling in limb outgrowth and patterning
    Benoit Robert
    Institut Pasteur, Unité de Recherche Associée 2578 Centre National de la Recherche Scientifique, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Growth Differ 49:455-68. 2007
    ..Particular attention is paid to the methodology, its power and its limits...
  101. ncbi Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities
    N Oya
    Department of Radiology, Kyoto University, Faculty of Medicine, Sakyo ku, Kyoto, Japan
    Int J Radiat Oncol Biol Phys 51:87-93. 2001
    ..To evaluate the outcome and adverse effects in patients with osteosarcoma treated with very high-dose definitive intraoperative radiotherapy (IORT), with the intention of saving the affected limb...

Research Grants76

  1. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..Furthermore, diabetes is the leading cause of nontraumatic amputations of lower extremities in the United States, and approximately 14-24 % of patients with diabetes who develop a foot ulcer will have an ..
  2. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    ..root ganglion (DRG) neurons innervating pelvic organs but not the somatosensory distribution to the lower extremities. Specifically, our preliminary data support two highly novel hypotheses: 1...
  3. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..Clinical disease results from occlusion of vessels that feed the heart, brain, or extremities. The early stages of atherosclerosis (atherogenesis) involve inflammatory injury to the vessel wall, ..
  4. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..The nerve degeneration causes the subsequent degeneration of the muscles in the extremities. Among the symptoms of CMT are foot-drop, steppage gait, high arches, foot bone abnormalities, and basic ..
  5. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..of PAD, which impairs the ability to walk and causes pain, nonhealing ulcers and gangrene in the lower extremities. It is a significant public health burden and, at its worst, leads to leg amputations...
  6. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..also affects the appendicular skeleton, a question of high clinical importance as young adolescents fracture extremities much more commonly than the axial skeleton...
  7. MicroRNA Regulation of Macrophage Polarization in Muscle Regeneration
    Paula K Shireman; Fiscal Year: 2013
    ..Skeletal muscle, while being the tissue most vulnerable to ischemic damage in the extremities, also has an amazing potential to regenerate due to satellite cells...
  8. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..brain each year, which enhances the risk of white matter injuries and consequent cerebral palsy (weakness in extremities), and cognitive deficits--writing and reading difficulties...
  9. Integrated MRI-Based Examination for Evaluation of Peripheral Arterial Disease
    Felix W Wehrli; Fiscal Year: 2010
    ..PAD's clinical manifestations are caused by stenosing of the major arteries supplying the lower extremities (iliac, femoral and popliteal arteries)...
  10. Behavior Therapy for Adults with Tourette Syndrome
    Lawrence Scahill; Fiscal Year: 2009
    ..Tics can be brief, rapid and darting movements of the face, shoulders, and extremities or more complex and purposeful in appearance...
  11. Effect of botulinum toxin plus vibration on bone in children with cerebral palsy
    Christopher M Modlesky; Fiscal Year: 2012
    ..often treated with Botox and they already feature low bone mass and underdeveloped bone structure in the lower extremities. The long-term goal is to optimize bone development and minimize short and long-term fracture incidence in ..
  12. Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
    Marlyn Woo; Fiscal Year: 2013
    ..Passive limb movement, the rhythmic movement of extremities without voluntary effort, increases ventilation during sleep in subjects with intact spinal cords;the impact of ..
  13. Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema Monitoring
    William F Weitzel; Fiscal Year: 2013
    ..and bioimpedance modalities to accurately and quantitatively determine tissue hydration of peripheral extremities and transmit the data securely over telehealth communication lines...
  14. A Novel Electrospun Vascular Graft
    David J Vachon; Fiscal Year: 2010
    ..For PAD, this may lead to claudication and tissue morbidity of peripheral extremities, while for CAD this can lead to ischemia and often fatal myocardial infarction and, for cerebrovascular ..
  15. Nitric Oxide-Releasing Wound Dressing for Preventing Chronic Wound Infections
    NATHAN ALLAN STASKO; Fiscal Year: 2012
    ..have an increased risk of infection due to the slow healing times caused by poor blood circulation in the extremities and other associated co-morbidities...
  16. Effect of Intense Multi-Modal Training on Bone Mineral Density, Bone Biomarkers,
    Todd Anthony Astorino; Fiscal Year: 2013
    ..the effects of rehabilitation consisting of multiple exercise modalities providing loading of the lower extremities on bone health and body composition in this population...
  17. A New Device for Rapid Measurement of Touch Sensation in neuropathy
    Donald A Simone; Fiscal Year: 2010
    ..In neuropathy, sensory dysfunction almost always begins in the distal extremities (fingers or toes) where the sensation of touch is diminished or lost...
  18. Concurrent Upper/Lower Extremity SCI Exercise with Stimulation
    LEE BARNETT; Fiscal Year: 2010
    ..Currently available SCI exercises, however, are generally targeted at the lower extremities and provide no opportunity for a concurrent lower and upper extremity exercise...
  19. Targeting the Pial Collateral Circulation for Mitigation of Cerebral Ischemia
    James E Faber; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Occlusive vascular disease of the brain, heart and lower extremities is the primary cause of morbidity and mortality in the US...
  20. Lymphatic Filariasis Transmission and Elimination in Papua New Guinea
    Daniel J Tisch; Fiscal Year: 2013
    ..Disease" (NTD) that causes elephantiasis, disfigurement of the male genitalia and painful swelling of the extremities. For the past 10 years there has been intense global effort to eliminate LF due to Wuchereria bancrofti (Wb) ..
  21. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2010
    ..Cordo 2008), AMES was determined to be effective at restoring functional movement in both upper and lower extremities of low-functioning chronic stroke subjects (>1 yr post-stroke), several of which were plegic...
  22. Risk Factors for Osteoporosis in Children &Adolescents with Myelomeningocele
    Tishya A L Wren; Fiscal Year: 2013
    ..during the first month of pregnancy, resulting in varying degrees of paralysis and weakness in the lower extremities. Osteoporosis and fractures are common problems in this population, most likely due to decreased ambulation and ..
  23. Cell therapy for diabetic peripheral neurovascular complications
    YOUNG SUP contact YOON; Fiscal Year: 2011
    ..PAD is usually characterized by occlusive arterial disease of the lower extremities, and when advanced into the critical limb ischemia stage, can often lead to leg amputation...
  24. Neural Interface and Control Design to Restore Sensation in Amputees
    MATTHEW ANTHONY SCHIEFER; Fiscal Year: 2012
    ..Because the hands are key for manipulating the external environment, sensory feedback is critical in the upper extremities. The ideal artificial sensory feedback mechanism would be one that produces the exact same perception as the ..
  25. Novel Biological Tissue Lined Vascular Stent Crimping and Delivery System
    MICHAEL JOHN WIGGINS; Fiscal Year: 2010
    ..A major component of peripheral arterial disease (PAD) is obstruction of blood flow to the lower extremities from atherosclerosis...
  26. A Portable Wound Hemostasis System Using a Hydrogel Polymeric Foam
    Edward Rodriguez; Fiscal Year: 2013
    ..Reduction of deformity in injured extremities requires alignment and splints and compression dressings for open extremity non-arterial wounds...
  27. Influence of Core Stability on Running Mechanics in Novice Runners
    AJIT MOHAN WORTHEN CHAUDHARI; Fiscal Year: 2013
    ..mass resides in the upper body, and control of this mass will impact the forces received by the lower extremities. The lack of understanding of the role that the torso and pelvis play in running represents a critical barrier ..
  28. HIV and Global Drug Therapies: Peripheral Neuropathy Complications and Mechanisms
    Cecilia M Shikuma; Fiscal Year: 2012
    ..proposal will study whether low baseline peripheral nerve fiber density (the nerves responsible for pain in the extremities) will predict the development of neuropathy (pain in the extremities) and whether HIV-infected subjects on ..
  29. Phase II study: Mobilization of progenitor cells in peripheral arterial disease
    Arshed A Quyyumi; Fiscal Year: 2010
    ..SPECIFIC AIM. Atherosclerotic peripheral artery disease (PAD) of the lower extremities afflicts up to 5% of the U.S. population and is characterized by significant endothelial dysfunction...
  30. Computational Biomechanics for Prediction of Osteoporotic Vertebral Fracture Risk
    Chamith Sudesh Rajapakse; Fiscal Year: 2013
    ..on the basis of biomechanical analysis via in-vivo high-resolution magnetic resonance (mMR) images of distal extremities will be tested...
  31. Methods To Reduce Vein Harvest Injury
    Joyce Cheung-Flynn; Fiscal Year: 2013
    ..Vein graft failure leads to myocardia infarction and death in CABG patients, while in lower extremities, PV bypass failure leads to recurrent claudication and limb loss that negatively impacts quality of life...
  32. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ..These will show increased blood flow to lower extremities when upright. Central hypovolemia will occur and will reduce CBF and produce symptoms of CFS...
  33. Repair of Bladder Function after Cauda Equina Injury
    Leif A Havton; Fiscal Year: 2010
    ..Such injuries cause paralysis and sensory impairment of the lower extremities, pain, as well as bladder, bowel, and sexual dysfunctions...
  34. Body Worn EMG Controlling of Assistive Robotic Arm for Stroke Rehabilitation
    GARY D HAVEY; Fiscal Year: 2013
    ..Following a hemispheric stroke, motor control of extremities on one side of the body is usually affected...
  35. Characterization of nucleotide-dependent structural rearrangements in atlastin
    LAURA JEAN BYRNES; Fiscal Year: 2012
    ..is a group of inherited neurological disorders that cause progressive spasticity and weakness in the lower extremities. Mutations in the atlastin-1 gene, one of the major mutational hot spots in the disease, account for ~10% of ..
  36. Discovering a Novel Immunophilin to Lower the Toxicity of Cancer Therapeutics
    Mitchell W Mutz; Fiscal Year: 2012
    ..Initial symptoms of CIPN include sensory loss and pain in the extremities, and can later progress to uncontrolled bladder emptying, respiratory dysfunction, and paralysis...
  37. Predicting Skeletal Stability of Endoprostheses for Above Elbow Amputees
    Kent N Bachus; Fiscal Year: 2010
    ..Unfortunately, there is not adequate protection for the extremities and many US veterans are returning from combat with traumatic amputations that require follow-up care, ..
  38. Near Infrared Brain Imaging for Guiding Treatment in Children with Cerebral Palsy
    Georgios Alexandrakis; Fiscal Year: 2013
    ..reorganize their activity as a result of an early life stroke event that caused partial paralysis of the extremities. This condition is known as cerebral palsy, a common motor disorder in children...
  39. Platelet Activity &Cardiovascular Events following Vascular Surgery
    Jeffrey S Berger; Fiscal Year: 2013
    ..observational cohort study enrolling 350 subjects before non- emergent open vascular surgery of the lower extremities. Platelet activity will be measured before and after vascular surgery and will be correlated with 30-day and ..
  40. Identifying the Gene for Scleroderma in Tsk/2 mice that model Human SSc Subsets
    Elizabeth P Blankenhorn; Fiscal Year: 2013
    ..SSc patients show a continuum of disease severity, generally ranging from less severe fibrosis limited to the extremities, to a more severe and often fatal diffuse disease. Tsk2/+ mice are a model for SSc...
  41. Promoting Walking in African Americans with Peripheral Arterial Disease
    TRACIE CHIANTI COLLINS; Fiscal Year: 2013
    ..affects 12 million Americans and is defined as atherosclerosis of the abdominal aorta and arteries of the lower extremities. Compared to non-Hispanic whites, AAs are 2.3 to 2.8 times as likely to have PAD...
  42. Sacroiliitis in early ERA
    PAMELA FITCH WEISS; Fiscal Year: 2013
    ..ERA and PsA are characterized by enthesitis of the lower extremities and arthritis of the axial and peripheral skeleton...
  43. Image Science for the New X-Ray: Taking Dual-Energy CT to Task
    Jeffrey H Siewerdsen; Fiscal Year: 2013
    ..Translate the results to a prototype MSK extremities CBCT scanner (already constructed in a separate project) to implement and evaluate optimal DE-CBCT techniques ..
  44. Early Events in KSVH Infection of Primary B-cells
    Erle S Robertson; Fiscal Year: 2013
    ..KS of the soft palate as well as major involvement of the body and extremities has been known to be a common symptom associated with the onset of AIDS in the HIV immunocompromised population...
  45. Phase I Study of HSV1716 in Pediatric Non-CNS Solid Tumors,IND 13196 12/04/2006
    James I Geller; Fiscal Year: 2011
    ..that intratumoral injection of HSV1716 is safe in young patients with tumors in superficial regions (extremities, head and neck) as well as retroperitoneal and lung locations, with minimal shedding of virus...
  46. Polymicrobial dynamics in transfer of vancomycin resistance to MRSA
    Matthew Ramsey; Fiscal Year: 2013
    ..This has happened at least 12 times independently during the course of infection, mainly in lesions on the extremities of diabetics. All S. aureus recipients of the vancomycin resistance transposon have been of a single S...
  47. Dys-regulation of Mitochondrial Motility in Parkinsonian Neurodegeneration
    Xinnan Wang; Fiscal Year: 2010
    ..and undergo fission and fusion in all eukaryotic cells, but the need to supply mitochondria to the far-flung extremities of neurons creates a particular urgency for mitochondrial transport in neurons...
  48. CONSOLE FOR 10.5 TESLA WHOLE BODY MRI SYSTEM
    Kamil Ugurbil; Fiscal Year: 2010
    ..large bore size (83 cm clear bore) to perform studies on the human brain as well as the human torso and extremities. 10.5 T represents a significant increase over the current, most commonly available ultrahigh field platform, i...
  49. Clinical and neurophysiological study of subthalamic brain stimulation in PD
    HARRISON CARROLL WALKER; Fiscal Year: 2013
    ..Kinematic testing in the bilateral extremities of central and peripheral reaction time and movement time will be obtained at high and low stimulation ..
  50. Exercise as a Treatment for Tongue Weakness
    NADINE PATTAKOS CONNOR; Fiscal Year: 2013
    ..Sarcopenia is not limited to muscles within the extremities;age-related decrements in critical cranial functions, such as swallowing, have also been reported...
  51. Risk Factors of Epilepsy Outcomes: Comorbidities in Population with Epilepsy
    Anbesaw W Selassie; Fiscal Year: 2013
    ..the magnitude and distribution common comorbid conditions among PWE (Case group) relative to persons with extremities fracture (EF) and delirium/syncope (DS) (Comparative Groups).HA1a...
  52. Dissection of genetic pathways critical for myelinating Schwann cell development
    Anthony Antonellis; Fiscal Year: 2013
    ..neuropathies are a group of diseases characterized by impaired motor function and sensory loss in the extremities. Between 2-8% of the general population is affected with a peripheral neuropathy, making these diseases a ..
  53. A Novel Thin Film Nitinol Covered Stent to Treat Peripheral Arterial Disease
    David A Rigberg; Fiscal Year: 2010
    ..Arterial occlusive disease of the extremities occurs in 3-10% of the population and increases to 10-15% in persons over 70 years...
  54. Anatomic and functional predictors of arteriovenous fistula maturation
    Miguel A Vazquez; Fiscal Year: 2012
    ..a combination of anatomic and functional abnormalities of the arterial and venous circulations of the upper extremities predict AV fistula maturation failure in patients with stage 4 and 5 chronic kidney disease...
  55. Video Motion Analysis of Repetitive Exertions
    Robert G Radwin; Fiscal Year: 2013
    ..using sequential Bayesian estimation to track the motion of a general region of interest (ROI) on the upper extremities selected by the camera operator or analyst, and statistically estimating its velocity and acceleration...
  56. The UAB Spina Bifida Patient Registry Demonstration Project
    David B Joseph; Fiscal Year: 2010
    ..number of obstacles including hydrocephalus in more that 90% of cases, as well as paralysis and weakness of the extremities and decreased bladder/bowel control. Phase I of the project was highly successful...
  57. Topical Therapeutic to Promote Healing of Chronic Wounds
    SUSAN PARK PERRINE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic refractory, or non-healing, wounds or ulcerations of the extremities represent a major medical condition affecting millions of patients...
  58. High-Sensitivity Flexible MRI Coils via Printed Electronics
    Michael Lustig; Fiscal Year: 2013
    ..This problem is exacerbated in pediatric imaging, and also around adult extremities such as ankles, knees, neck and shoulders...
  59. Genetic and genomic approaches for studying inherited peripheral neuropathies
    Anthony Antonellis; Fiscal Year: 2010
    ..neuropathies are a group of diseases characterized by impaired motor function and sensory loss in the extremities. About 2...
  60. Supraspinal Contributions to Locomotor Control and Recovery after Stroke
    Sheila M Schindler-Ivens; Fiscal Year: 2013
    ..project proposed here is to use fMRI to understand how the brain controls locomotor-like movements of the lower extremities in people post stroke. Pedaling will be used as a model of locomotion...
  61. Systems Biology of Angiogenesis in Peripheral Arterial Disease
    Aleksander S Popel; Fiscal Year: 2013
    ..applicant): Peripheral arterial disease (PAD), caused by atherosclerosis that impairs blood flow to the lower extremities, is a major health problem...
  62. Facilitating the Recovery of Function Following Stroke: The Efficacy of Inosine
    Tara L Moore; Fiscal Year: 2013
    ..experience a new or recurrent stroke each year, and 80% of these experience impairment of motor function of the extremities. Partial recovery of motor function occurs even without pharmacological interventions...
  63. A New Biomechanical Model to Examine Joint Control Adaptations during Running in
    Jae Kun Shim; Fiscal Year: 2013
    ..Using this model we propose to assess the force transmission through the lower extremities and the biomechanical adaptations of ILEA running with RSPs...
  64. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX II
    CHARLES HALES; Fiscal Year: 2003
    ..disease (PE or deep venous thrombosis), ventilation/perfusion lung scan, or compression ultrasound of the lower extremities. Pulmonary embolism will be diagnosed on the basis of a high probability ventilation/perfusion lung scan in ..
  65. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2007
    ..a pre-clinical trial, we showed AMES to be effective at restoring functional movement in both upper and lower extremities in a majority of profoundly disabled chronic stroke patients (>2 yr event)...
  66. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    ..disorders of the lymphatic system that lead to disfiguring and often disabling edema (swelling) of the extremities together with various associated abnormalities...
  67. AGE, SENSATION AND FALLS--BIOMECHANICS AND PREVENTION
    Ge Wu; Fiscal Year: 1999
    ..somatosensory input by testing subjects with peripheral neuropathy who have decreased sensation in their lower extremities. The kinematic measurements will be carried out using the integrated kinematic sensor that was developed by the ..
  68. Primate Model of Stroke and Recovery in Aging
    Tara Moore; Fiscal Year: 2009
    ..late middle age and early senescence, results in cortical injury that frequently affects motor activity of the extremities. Given the number of individuals that experience a stroke each year there is a critical need to understand the ..
  69. INFERIOR VENA CAVA FILTRATION WITH A REMOVABLE DEVICE
    Elvira Lang; Fiscal Year: 1999
    ..In 1994, in non-Federal short-stay hospitals, 474,000 patients underwent joint replacement of the lower extremities and 89,000 underwent other repair of lower extremities; in addition 27,000 patients with complications in ..
  70. EXERCISE--NURSING INTERVENTION FOR FUNCTIONAL RECOVERY
    Beverly Roberts; Fiscal Year: 2000
    ..The proposed low intensity exercise program is targeted to the lower extremities and is designed to increase muscle strength and range of motion in the lower extremities and trunk, gait and ..
  71. Controlled Release Vascular Grafts
    ANTONIO WEBB; Fiscal Year: 2009
    ..PAD is characterized by a gradual reduction in blood flow to the muscular arteries of the lower extremities caused by atherosclerosis...
  72. HYPERTHERMIA AND PERFUSION EFFECTS IN CANCER THERAPY
    Mark Dewhirst; Fiscal Year: 2009
    ..Project 1 will develop MR-based non-invasive thermometry in tumors of extremities, breast and pelvis/abdomen using fully integrated MR compatible RF heating devices...
  73. PROSPECTIVE INVESTIGATION OF PE DX-II
    Kenneth Leeper; Fiscal Year: 2003
    ..V/Q lung scan in patients without prior PE, pulmonary angiography, or compression ultrasound of the lower extremities in patients with no prior deep venous thrombosis...
  74. Role of metalloproteinases in deep vein thrombosis
    Khanh Nguyen; Fiscal Year: 2009
    ..DVT) is a disease condition where blood clots (thrombi) develop in deep veins, often veins of the lower extremities. This disease affects more than 2 million Americans annually;approximately 25-75% of these patients will go on ..
  75. DORSAL SPINAL CORD STIMULATION--VASODILATOR MECHANISMS
    Robert Foreman; Fiscal Year: 2001
    ..studies indicate that the beneficial effect of SCS in PVD is associated with increased blood flow to the extremities. Previous work from the applicant's laboratory has demonstrated that SCS-induced vasodilation is mediated by ..
  76. BIOMECHANICS OF THE UE IN WHEELCHAIR PROPULSION
    Kai Nan An; Fiscal Year: 2002
    ..A systematic evaluation of the loads on the upper extremities of wheelchair users will do much to improve our understanding, treatment and ability to prevent musculoskeletal ..