nipples

Summary

Summary: The conic organs which usually give outlet to milk from the mammary glands.

Top Publications

  1. pmc Skin-sparing mastectomy with conservation of the nipple-areola complex and autologous reconstruction is an oncologically safe procedure
    Bernd Gerber
    Department of Obstetrics and Gynecology, LMU Munich, Maistrasse 11, 80337 Munich, Germany
    Ann Surg 238:120-7. 2003
  2. ncbi Issues related to choice of breast reconstruction in early-stage breast cancer
    Kristina O'Shaughnessy
    Northwestern Plastic and Reconstructive Surgery, 675 North St Clair Street, 19th Floor, Chicago, IL 60611, USA
    Curr Treat Options Oncol 7:129-39. 2006
  3. ncbi Breastfeeding women's experience of expressing: a descriptive study
    Sarah N Clemons
    Alfred Hospital, Melbourne, Australia
    J Hum Lact 26:258-65. 2010
  4. ncbi The oncological safety of skin sparing mastectomy with conservation of the nipple-areola complex and autologous reconstruction: an extended follow-up study
    Bernd Gerber
    Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany
    Ann Surg 249:461-8. 2009
  5. pmc Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface
    Julie Ann Mayer
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Pathol 173:1339-48. 2008
  6. ncbi Escaping from Flatland: clinical and biological aspects of human mammary duct anatomy in three dimensions
    James J Going
    Department of Pathology, University of Glasgow, Glasgor Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, Scotland, UK
    J Pathol 203:538-44. 2004
  7. ncbi Update on the indications for nipple-sparing mastectomy
    Carlos A Garcia-Etienne
    Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Support Oncol 4:225-30. 2006
  8. ncbi Applicability of the nipple-areola complex-sparing mastectomy: a prediction model using mammography to estimate risk of nipple-areola complex involvement in breast cancer patients
    Amy K Schecter
    North Shore Long Island Jewish Health System, Department of General Surgery, New Hyde Park, NY, USA
    Ann Plast Surg 56:498-504; discussion 504. 2006
  9. ncbi Zymographic analyses and measurement of matrix metalloproteinase-2 and -9 in nipple aspirate fluids
    Ferdinando Mannello
    Istituto di Istologia and Analisi di Laboratorio, Facoltà di Scienze Matematiche, Fisiche e Naturali, Università degli Studi Carlo Bo, Via E Zeppi, 61029 Urbino PU, Italy
    Clin Chem 49:1546-50. 2003
  10. ncbi Skin-sparing mastectomy
    Giles H Cunnick
    Department of Breast Surgery, St George s Hospital, Tooting, London, United Kingdom
    Am J Surg 188:78-84. 2004

Detail Information

Publications278 found, 100 shown here

  1. pmc Skin-sparing mastectomy with conservation of the nipple-areola complex and autologous reconstruction is an oncologically safe procedure
    Bernd Gerber
    Department of Obstetrics and Gynecology, LMU Munich, Maistrasse 11, 80337 Munich, Germany
    Ann Surg 238:120-7. 2003
    ..Is skin-sparing mastectomy (SSM) with conservation of the Nipple-Areola Complex (NAC) and immediate autologous reconstruction as safe in oncologic terms as SSM with resection of the NAC as modified radical mastectomy (MRM)?..
  2. ncbi Issues related to choice of breast reconstruction in early-stage breast cancer
    Kristina O'Shaughnessy
    Northwestern Plastic and Reconstructive Surgery, 675 North St Clair Street, 19th Floor, Chicago, IL 60611, USA
    Curr Treat Options Oncol 7:129-39. 2006
    ..This approach avoids radiation damage to tissue reconstruction flaps, saving them for use later if necessary. This approach, using a tissue expander as a first step, is growing in popularity...
  3. ncbi Breastfeeding women's experience of expressing: a descriptive study
    Sarah N Clemons
    Alfred Hospital, Melbourne, Australia
    J Hum Lact 26:258-65. 2010
    ..Adverse effects of pumps were pain (17%, 126/737) and damage to nipples (11%, 86/737)...
  4. ncbi The oncological safety of skin sparing mastectomy with conservation of the nipple-areola complex and autologous reconstruction: an extended follow-up study
    Bernd Gerber
    Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany
    Ann Surg 249:461-8. 2009
    ..To find out if skin sparing mastectomy (SSM) and nipple sparing mastectomy (NSM) with immediate autologous reconstruction as safe in oncological terms as modified radical mastectomy (MRM)...
  5. pmc Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface
    Julie Ann Mayer
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Pathol 173:1339-48. 2008
    ..We propose that during evolution of the nipple, the BMP pathway was co-opted to suppress hair follicle formation and create a more functional milk delivery apparatus...
  6. ncbi Escaping from Flatland: clinical and biological aspects of human mammary duct anatomy in three dimensions
    James J Going
    Department of Pathology, University of Glasgow, Glasgor Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, Scotland, UK
    J Pathol 203:538-44. 2004
    ..The mastectomy nipples contained 11-48 central ducts (median 27, inter-quartile range 21-30)...
  7. ncbi Update on the indications for nipple-sparing mastectomy
    Carlos A Garcia-Etienne
    Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Support Oncol 4:225-30. 2006
    ..Although the current role of NSM seems to be more defined as a prophylactic procedure in high-risk patients, prospective studies and reports are needed to better define its indications...
  8. ncbi Applicability of the nipple-areola complex-sparing mastectomy: a prediction model using mammography to estimate risk of nipple-areola complex involvement in breast cancer patients
    Amy K Schecter
    North Shore Long Island Jewish Health System, Department of General Surgery, New Hyde Park, NY, USA
    Ann Plast Surg 56:498-504; discussion 504. 2006
    ..These preliminary findings indicate that the NACIS formula may be a useful clinical tool for selecting low-risk patients for total NAC-sparing mastectomy with immediate reconstruction...
  9. ncbi Zymographic analyses and measurement of matrix metalloproteinase-2 and -9 in nipple aspirate fluids
    Ferdinando Mannello
    Istituto di Istologia and Analisi di Laboratorio, Facoltà di Scienze Matematiche, Fisiche e Naturali, Università degli Studi Carlo Bo, Via E Zeppi, 61029 Urbino PU, Italy
    Clin Chem 49:1546-50. 2003
  10. ncbi Skin-sparing mastectomy
    Giles H Cunnick
    Department of Breast Surgery, St George s Hospital, Tooting, London, United Kingdom
    Am J Surg 188:78-84. 2004
    ..It facilitates immediate breast reconstruction using an implant or myocutaneous flap, resulting in excellent cosmesis...
  11. ncbi Nipple-sparing mastectomy
    J E Rusby
    Academic Surgery, Royal Marsden NHS Foundation Trust, London, UK
    Br J Surg 97:305-16. 2010
    ..Nipple-sparing mastectomy aims to address this, but there is no consensus on its clinical application. Evidence relating to oncological safety, surgical technique and early data on aesthetic outcome was reviewed...
  12. ncbi Nipple sparing mastectomy with nipple areola intraoperative radiotherapy: one thousand and one cases of a five years experience at the European institute of oncology of Milan (EIO)
    J Y Petit
    Plastic Surgery Department, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast Cancer Res Treat 117:333-8. 2009
    ..Overall, 36 cases of metastases and 4 deaths were observed. No significant outcome difference was observed between the 800 patients receiving intraoperative radiotherapy (ELIOT) and the 201 patients receiving delayed irradiation...
  13. pmc Sections of the nipple and quadrants in mastectomy specimens for carcinoma are of limited value
    K Sikand
    Department of Histopathology, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 58:543-5. 2005
    ..To assess the value of nipple and quadrant sections in mastectomy specimens for carcinoma in detecting Paget's disease and multifocal carcinoma...
  14. ncbi Different panels of markers should be used to predict mammary Paget's disease associated with in situ or invasive ductal carcinoma of the breast
    Todd Lester
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Clin Lab Sci 39:17-24. 2009
    ....
  15. ncbi Technical considerations in nipple-sparing mastectomy: 82 consecutive cases without necrosis
    Alan J Stolier
    Department of Surgery, Tulane University, 2525 Severn Ave, Metairie, New Orleans, LA 70002, USA
    Ann Surg Oncol 15:1341-7. 2008
    ..As yet, there are no established techniques that are universally applied to NSM. Herein we describe our surgical approach...
  16. ncbi Nipple-sparing mastectomy in 99 patients with a mean follow-up of 5 years
    J Arthur Jensen
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 18:1665-70. 2011
    ..The safety and practicality of nipple-sparing mastectomy (NSM) are controversial...
  17. ncbi High basic fibroblast growth factor levels in nipple aspirate fluid are correlated with breast cancer
    Robbin Hsiung
    Department of Surgery, Thomas Jefferson University Philadelphia, Pennsylvania 19107, USA
    Cancer J 8:303-10. 2002
    ....
  18. ncbi Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report
    Robert N Page
    University of Tennessee Department of Pathology, Knoxville, USA
    J Cutan Pathol 36:1206-9. 2009
    ....
  19. ncbi Nipple adenoma arising in a supernumerary mammary gland: a case report
    Louise Shinn
    Department of General Surgery, Norfolk and Norwich University Hospital, Colnet Lane, Norwich, Norfolk, United Kingdom
    Tumori 97:812-4. 2011
    ..that diseases of the breast and nipple-areola complex may also arise in accessory mammary tissue and accessory nipples should not be discounted as a common congenital anomaly...
  20. ncbi The nipple-areola complex epidermis: a prospective systematic study in adult autopsies
    Jose Fernando Val-Bernal
    Department of Anatomical Pathology, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
    Am J Dermatopathol 32:787-93. 2010
    ..complex of adult autopsies of both sexes not suffering from breast cancer was studied in a total of 140 nipples. The epidermis of the nipple-areola complex shows squamous cells and 3 types of clear cells: Toker cells, ..
  21. ncbi Occult nipple involvement in breast cancer: clinicopathologic findings in 316 consecutive mastectomy specimens
    Elena F Brachtel
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 27:4948-54. 2009
    ..This study evaluates frequency and patterns of occult nipple involvement in a large contemporary cohort of patients with the retroareolar margin as possible indicator of nipple involvement...
  22. ncbi Nipple adenoma: a differential diagnosis for Paget's disease
    Clara Elizabeth Healy
    Surgical Professorial Unit, St Vincent s University Hospital, Elm Park, Dublin, Ireland
    Breast J 9:325-6. 2003
  23. ncbi Nipple involvement in breast cancer: retrospective analysis of 2323 consecutive mastectomy specimens
    - Weidong Li
    Cancer Hospital and Institution of Tianjin Medical University, Tianjin, China
    Int J Surg Pathol 19:328-34. 2011
    ..A total of 2323 consecutive mastectomy specimens with grossly unremarkable nipples were evaluated by sagittal sections through the entire nipple and subareolar tissue...
  24. ncbi Prostate-specific antigen production in the female breast: association with progesterone
    E R Sauter
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Epidemiol Biomarkers Prev 7:315-20. 1998
    ..NAF may, therefore, be useful as a breast cancer screening tool for young women who are not recommended to undergo mammography and as an adjunct to screen women who have mammograms performed...
  25. ncbi Dermoscopic features of accessory nipples
    Murat Orhan Oztas
    Department of Dermatology, Faculty of Medicine, Gazi University, Ankara, Turkey
    Int J Dermatol 46:1067-8. 2007
    ..Dermoscopic examination showed a central white area, central streak, and a very faint pigmented network at the periphery...
  26. ncbi Nipple-sparing mastectomy: technique and results of 54 procedures
    Joseph P Crowe
    Departments of General Surgery and Plastic Surgery, The Cleveland Clinic Breast Center, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Arch Surg 139:148-50. 2004
    ..Neoplastic involvement of the NAC can be predicted before surgery and assessed during the operation, and sustained postoperative viability of the NAC is likely with appropriate surgical technique...
  27. ncbi Infiltrating syringomatous adenoma of the nipple: clinical presentation and literature review
    Khine Z Oo
    Department of Hematology Oncology, The Brooklyn Hospital Center, Brooklyn, New York 11201, USA
    Arch Pathol Lab Med 133:1487-9. 2009
    ..Special attention given to this tumor by pathologists and clinicians can avoid misdiagnosis and unnecessary treatment...
  28. pmc Cancer of the breast with nipple involvement
    R S Menon
    Department of Pathology Dr Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands
    Br J Cancer 59:81-4. 1989
    ..Multiple transverse sections showed tumour in 19 nipples (58%) involving one or more levels. Of these, 17 showed non-invasive tumour, either ductal or lobular type...
  29. ncbi Risk factors for suboptimal infant breastfeeding behavior, delayed onset of lactation, and excess neonatal weight loss
    Kathryn G Dewey
    Department of Nutrition, University of California, Davis 95616 8669, USA
    Pediatrics 112:607-19. 2003
    ....
  30. ncbi Nipple sparing subcutaneous mastectomy: sixty-six months follow-up
    F Caruso
    Department of Surgical Oncology, Humanitas Centro Catanese di Oncologia, Via Dabormida 64, 95100 Catania, Italy
    Eur J Surg Oncol 32:937-40. 2006
    ..Validation of oncological and reconstructive efficacy of nipple sparing subcutaneous mastectomy...
  31. ncbi Development and validation of a model predictive of occult nipple involvement in women undergoing mastectomy
    J E Rusby
    Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Br J Surg 95:1356-61. 2008
    ..This prospective study aimed to build a predictive model using preoperative information to aid selection for nipple-sparing mastectomy...
  32. ncbi Patient and duct selection for nipple duct lavage
    April Johnson Maddux
    Department of Surgery, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
    Am J Surg 188:390-4. 2004
    ....
  33. pmc A descriptive study of mastitis in Australian breastfeeding women: incidence and determinants
    Lisa H Amir
    Mother and Child Health Research, La Trobe University, Melbourne, Australia
    BMC Public Health 7:62. 2007
    ....
  34. ncbi Painful nipples in nursing mothers: fungal or staphylococcal? A preliminary study
    Stephen Graves
    Department of Clinical and Biomedical Sciences, University of Melbourne, Victoria
    Aust Fam Physician 32:570-1. 2003
  35. ncbi Nipple-sparing mastectomy: initial experience at the Memorial Sloan-Kettering Cancer Center and a comprehensive review of literature
    Carlos A Garcia-Etienne
    Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, New York NY 10021, USA
    Breast J 15:440-9. 2009
    ..However, available published data show that NSM can be safely performed for breast cancer treatment in carefully selected cases. Further studies and longer follow-up are necessary to refine selection criteria for NSM...
  36. ncbi Nipple areola skin-sparing mastectomy with immediate transverse rectus abdominis musculocutaneous flap reconstruction is an oncologically safe procedure: a single center study
    Hee Jeong Kim
    Department of Surgery, College of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea
    Ann Surg 251:493-8. 2010
    ..The present study evaluated the oncological safety and technical outcomes following nipple areola skin-sparing mastectomy (NASSM), skin-sparing mastectomy (SSM), and mastectomy...
  37. ncbi Analysis of nipple/areolar involvement with mastectomy: can the areola be preserved?
    Rache M Simmons
    Department of Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA
    Ann Surg Oncol 9:165-8. 2002
    ..Most patients undergoing SSM desire reconstruction of the nipple/areolar complex for symmetry. These data explore the possibility of preserving the areola in selected mastectomy patients...
  38. ncbi Presence of epithelial cells in nipple aspirate fluid is associated with subsequent breast cancer: a 25-year prospective study
    Gertrude Case Buehring
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
    Breast Cancer Res Treat 98:63-70. 2006
    ..1 for any breast cancer, 2.5 for invasive breast cancer). We conclude that presence of NAF with epithelial cells is associated with subsequent breast cancer risk and may be a useful marker for women at higher risk...
  39. ncbi Proteomic characterization of nipple aspirate fluid: identification of potential biomarkers of breast cancer
    Susan M Varnum
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Breast Cancer Res Treat 80:87-97. 2003
    ..In summary, this study provides the first characterization of the NAF proteome and identifies several candidate proteins for future studies on breast cancer markers in NAF...
  40. ncbi Nipple aspirate fluid cytology in breast carcinoma
    Savitri Krishnamurthy
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 99:97-104. 2003
    ..Cytologic-histologic correlations of NAF were performed in only a few studies...
  41. ncbi The absence of Candida albicans in milk samples of women with clinical symptoms of ductal candidiasis
    Thomas W Hale
    Department of Pediatrics, Texas Tech University School of Medicine, 1400 Coulter Boulevard, Amarillo, TX 79106, USA
    Breastfeed Med 4:57-61. 2009
    ..The objective of this prospective study was to determine if Candida albicans is present in the milk of women suffering from symptoms of severe nipple and deep breast pain...
  42. ncbi Breast duct microendoscopy in nipple discharge: microbrush improves cytology
    N Beechey-Newman
    Department of Academic Oncology, Breast Unit, 3rd Floor, Thomas Guy House, Guy s Hospital, London, SE1 9RT, United Kingdom
    Surg Endosc 19:1648-51. 2005
    ..It was the aim of this study to investigate the use of BDME in patients with pathological nipple discharge and to explore the feasibility of using an endoluminal microbrush to take cytology samples from specific lesions...
  43. ncbi Nipple-sparing mastectomy and immediate tissue expander/implant breast reconstruction
    Constance M Chen
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Plast Reconstr Surg 124:1772-80. 2009
    ..The authors evaluated the risks and benefits of nipple- or areola-sparing mastectomy with breast reconstruction...
  44. pmc Nipple aspirate fluid: a promising non-invasive method to identify cellular markers of breast cancer risk
    E R Sauter
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Br J Cancer 76:494-501. 1997
    ..This suggests that biomarkers identified in nipple aspirate fluid may prove useful either as an adjunct to currently accepted breast cancer screening methods, or to evaluate response to a chemopreventive agent...
  45. ncbi Diagnostic value of ductoscopy in the diagnosis of nipple discharge and intraductal proliferations in comparison to standard methods
    Susanne Grunwald
    Department of Obstetrics and Gynecology, Ernst Moritz Arndt University, Greifswald, Germany
    Onkologie 30:243-8. 2007
    ..Ductoscopy is gaining increased importance in the diagnosis of nipple discharge of unclear origin and intraductal proliferation. For this reason we compared its diagnostic value and feasibility to standard diagnostic methods...
  46. ncbi Detection of chromosomal aneusomy by fluorescence in situ hybridization for patients with nipple discharge
    Daigo Yamamoto
    Department of Surgery, Kansai Medical University, Osaka, Japan
    Cancer 97:690-4. 2003
    ..Therefore, we studied the clinical usefulness of fluorescence in situ hybridization (FISH) analysis of a numerical aberration of chromosomes (aneusomy) using ductal lavage from patients with nipple discharge...
  47. ncbi Ductography of the breast: technique and findings
    G Cardenosa
    Susan G Komen Breast Center, St Francis Medical Center, Peoria, IL 61614
    AJR Am J Roentgenol 162:1081-7. 1994
    ..In an effort to demonstrate the usefulness of ductography and encourage its increased use, we review the technique and illustrate normal and abnormal findings...
  48. pmc Ductographic findings of breast cancer
    Nariya Cho
    Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul, Korea
    Korean J Radiol 6:31-6. 2005
    ..In such cases, meticulous ductographic examinations and interpretations were crucial in order not to miss breast cancers...
  49. ncbi The relationship between positioning, the breastfeeding dynamic, the latching process and pain in breastfeeding mothers with sore nipples
    Anna Blair
    Healthy Children Project, 327 Quaker Meeting House Road, East Sandwich, MA 02537, USA
    Breastfeed Rev 11:5-10. 2003
    ..However, many mothers experience such painful sore nipples that they stop breastfeeding before they intended...
  50. ncbi The diagnostic value of nipple discharge cytology in 618 consecutive patients
    B W Kooistra
    Department of Surgery, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands
    Eur J Surg Oncol 35:573-7. 2009
    ..Nevertheless, cytological examination is considered to be a diagnostic aid. The aim of this study was to determine its complementary value in clinical decision-making in patients presenting with ND...
  51. ncbi Failure of high risk women to produce nipple aspirate fluid does not exclude detection of cytologic atypia in random periareolar fine needle aspiration specimens
    Priyanka Sharma
    Department of Internal Medicine, Division of Hematology Oncology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Breast Cancer Res Treat 87:59-64. 2004
    ..Evidence of hyperplasia with atypia found both on random periareolar fine needle aspiration (RPFNA) and in nipple aspirate fluid (NAF) fluid are associated with an increased risk for breast cancer...
  52. ncbi Terminal duct lobular units are scarce in the nipple: implications for prophylactic nipple-sparing mastectomy: terminal duct lobular units in the nipple
    Alan J Stolier
    Tulane University Department of Surgery and Omega Hospital, 2525 Severn Ave, New Orleans, LA, USA
    Ann Surg Oncol 15:438-42. 2008
    ..There is evidence to suggest that ductal and lobular breast cancer arises in the terminal duct/lobular unit (TDLU). This study was undertaken to determine whether TDLUs exist in the nipple and if so, to what extent...
  53. ncbi Short-term breast cancer prediction by random periareolar fine-needle aspiration cytology and the Gail risk model
    C J Fabian
    Division of Clinical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City 66160 7820, USA
    J Natl Cancer Inst 92:1217-27. 2000
    ....
  54. doi Polymerase chain reaction in detection of Candida albicans for confirmation of clinical diagnosis of nipple thrush
    Mariana Panjaitan
    Breastfeed Med 3:185-7. 2008
  55. pmc Ductoscopic biopsy of papillary tumors in women with nipple discharge
    Michael Hunerbein
    Ann Surg 245:154-5. 2007
  56. ncbi Optimizing the total skin-sparing mastectomy
    Akushla Wijayanayagam
    Carol Franc Buck Breast Care Center, Department of Surgery, University of California, San Francisco, 1600 Divisidero St, Box 1710, San Francisco, CA 94115 1710, USA
    Arch Surg 143:38-45; discussion 45. 2008
    ..Dissection of subnipple tissue to spare the entire skin envelope of the breast (total skin-sparing mastectomy) is a feasible option in appropriately selected patients and yields an excellent final cosmetic outcome...
  57. ncbi Nipple-sparing mastectomy
    Scott L Spear
    Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA
    Plast Reconstr Surg 123:1665-73. 2009
    ..Over the past several years, it has become more widely accepted, especially in the setting of prophylactic mastectomy, but its role in the treatment of breast cancer has only recently been reexamined...
  58. ncbi Reduced expression of the PTH/PTHrP receptor during development of the mammary gland influences the function of the nipple during lactation
    Tatsuya Kobayashi
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Dev Dyn 233:794-803. 2005
    ..in Ppr expression permitted progression of mammary gland development beyond the induction stage, but the nipples of these mice were dramatically smaller than those of controls, with altered epidermis and connective tissue...
  59. pmc The role of major duct excision and microdochectomy in the detection of breast carcinoma
    Mary F Dillon
    Department of Surgery, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    BMC Cancer 6:164. 2006
    ..The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma...
  60. ncbi Areola-sparing mastectomy with immediate breast reconstruction
    Rache M Simmons
    Department of Surgery, New York Presbyterian Hospital, Weill Medical College of Cornell University, and Weill Cornell Breast Center, 425 East 61st Street, 8th Floor, New York, NY 10021, USA
    Ann Plast Surg 51:547-51. 2003
    ..There was 1 postoperative complication, which consisted of a localized wound infection. Overall the authors found that ASM with immediate reconstruction provides excellent aesthetic results with infrequent complications...
  61. ncbi Lack of effect of celecoxib on prostaglandin E2 concentrations in nipple aspirate fluid from women at increased risk of breast cancer
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, One Hospital Drive, Room M588, Columbia, MO 65212, USA
    Cancer Epidemiol Biomarkers Prev 13:1745-50. 2004
    ..Among these, prostaglandin E(2) (PGE(2)) has tumor growth-promoting activity. The COX-2 isoform is the primary enzyme involved in PGE(2) production in cancerous tissue...
  62. pmc Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer
    Susan A Higgins
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Breast Cancer Res 7:R1017-22. 2005
    ..However, we observed a significantly lower proportion of fluid-yielding subjects in a similar series of high-risk women. The purpose of the present study was to identify variables associated with this reduction...
  63. ncbi Evaluating nipple discharge
    Aneela N Hussain
    Department of Family Medicine, State University of New York Health Science Center, Brooklyn, New York 11203, USA
    Obstet Gynecol Surv 61:278-83. 2006
    ..The evaluation and diagnosis of nipple discharge is important for the early detection of carcinoma, when present; and, in the case of benign disease, it is necessary to stop the incommodious discharge...
  64. ncbi [Characteristics, frequency and factors present in nipples damage occurence in lactating women]
    Gilcéria Tochika Shimoda
    Enfermeira do Hospital Universitário da Universidade de São Paulo
    Rev Bras Enferm 58:529-34. 2005
    ..The most of women presented complete healing of lesion from 5 to 6 days postpartum, this indicate that this period of a week is critical, when the mother needs stimulation and follow-up to the maintainance of lactation...
  65. ncbi Diagnostic value of signs and symptoms of mammary candidosis among lactating women
    Jimi Francis-Morrill
    Department of Nutrition, University of California, Davis 95616 8669, USA
    J Hum Lact 20:288-95; quiz 296-9. 2004
    ..Positive predictive value for Candida colonization was highest when there were 3 or more signs or symptoms simultaneously or when flaky or shiny skin of the nipple/areola was reported together or in combination with breast pain...
  66. ncbi Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy
    Anees Chagpar
    Department of Surgery, Division of Surgical Oncology, University of Louisville, Louisville, KY, USA
    Arch Surg 139:614-8; discussion 618-20. 2004
    ..Subareolar or periareolar injection of radioactive technetium sulfur colloid is equivalent to other injection techniques for breast cancer sentinel lymph node (SLN) biopsy...
  67. ncbi MR mammary ductography using a microscopy coil for assessment of intraductal lesions
    Yoshihide Kanemaki
    Department of Radiology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki City, Kanagawa 216 8511, Japan
    AJR Am J Roentgenol 182:1340-2. 2004
  68. ncbi Breast sonography in localizing the cause of nipple discharge: comparison with galactography in 52 patients
    Tarja Rissanen
    Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
    J Ultrasound Med 26:1031-9. 2007
    ..The purpose of this study was to evaluate breast sonography in localizing abnormalities in the discharging duct in patients with spontaneous nipple discharge...
  69. ncbi Directed duct excision by using mammary ductoscopy in patients with pathologic nipple discharge
    Jill R Dietz
    Departments of General Surgery and Biostatistics, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Surgery 132:582-7; discussion 587-8. 2002
    ..Duct excision for pathologic nipple discharge (PND) often requires "blind" surgical resection. Intraoperative mammary ductoscopy can allow for direct visualization of intraductal abnormalities during surgical resection...
  70. ncbi Microdochectomy for single-duct pathologic nipple discharge and normal or benign imaging and cytology
    Sophocles Lanitis
    Breast Care Unit, Mary Stanford Wing, 5th Floor, St Mary s Hospital NHS Trust, Praed Street, London W2 1NY, UK
    Breast 17:309-13. 2008
    ..Pre-operative workup and imaging may not be suspicious in patients with single-duct PND and underlying malignancy, therefore, microdochectomy should be considered in such cases...
  71. pmc A case-control study of mastitis: nasal carriage of Staphylococcus aureus
    Lisa H Amir
    Mother and Child Health Research, La Trobe University, Melbourne, Australia
    BMC Fam Pract 7:57. 2006
    ..Mastitis is a common problem for breastfeeding women. Researchers have called for an investigation into the possible role of maternal nasal carriage of S. aureus in the causation of mastitis in breastfeeding women...
  72. ncbi Multi-volume fusion imaging of MR ductography and MR mammography for patients with nipple discharge
    Masanori Hirose
    Department of Radiology, School of Medicine, Showa University, Japan
    Magn Reson Med Sci 5:105-12. 2006
    ..We herein introduce and describe this noninvasive method and discuss various factors related to its diagnostic use...
  73. ncbi Mammary ductoscopy for the evaluation of nipple discharge and comparison with standard diagnostic techniques
    Susanne Grunwald
    Department of Gynecology and Obstetrics, Ernst Moritz Arndt University, Greifswald, and Clinic of Minimally Invasive Surgery, Evangelic Hospital Hubertus, Berlin, Germany
    J Minim Invasive Gynecol 13:418-23. 2006
    ..To describe performance of breast duct endoscopy and compare the method with conventional diagnostic techniques...
  74. ncbi Breast cancer risk in women with abnormal cytology in nipple aspirates of breast fluid
    M R Wrensch
    Dept. of Epidemiology and Biostatistics, School of Medicine, Box 1215, University of California San Francisco, San Francisco, CA 94143, USA
    J Natl Cancer Inst 93:1791-8. 2001
    ..3 to 3.3). CONCLUSION: The results obtained with the newly followed women independently confirmed previous findings that women with abnormal cytology in nipple aspirates of breast fluid have an increased risk of breast cancer...
  75. pmc Celecoxib decreases prostaglandin E2 concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer
    Edward R Sauter
    Surgery, University of Missouri, Columbia, MO 65212, USA
    BMC Cancer 6:248. 2006
    ..The endpoints of the current study were to determine if a short course of celecoxib 400 mg bid would decrease PGE2 levels in women 1) at increased breast cancer risk, and 2) with established breast cancer...
  76. ncbi Nipple thrush
    Graeme Dennerstein
    Aust Fam Physician 32:392; author reply 392. 2003
  77. ncbi Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
    B S McIntyre
    CIIT Centers for Health Research, Six Davis Drive, P. O. Box 12137, Research Triangle Park, NC 27709-2137, USA
    Toxicol Sci 62:236-49. 2001
    ..Flutamide-induced alterations in AGD and areolae/nipples in early postnatal life correlated with a reduction in AGD and retained nipples observed in the adult...
  78. ncbi Nipple-sparing mastectomy in association with intra operative radiotherapy (ELIOT): A new type of mastectomy for breast cancer treatment
    Jean Yves Petit
    Division of Plastic Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 96:47-51. 2006
    ..In fact, although removal of the NAC greatly increases the patient's sensation of mutilation, and the risk of tumor involvement of the areola is reported as a very variable percentage, NAC excision still remains the standard treatment...
  79. ncbi Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry
    Timothy M Pawlik
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res Treat 89:149-57. 2005
    ..Proteomic screening techniques such as SELDI-MS analysis of NAF may be useful for breast cancer screening and diagnosis...
  80. ncbi Identification of quantitative trait loci affecting reproduction in pigs
    J P Cassady
    Animal Science Department, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 79:623-33. 2001
    ..in three replicates, for ovulation rate (n = 423), age at puberty (n = 295), litter size (n = 370), and number of nipples (n = 428). Litter-size data included number of fully formed, live, stillborn, and mummified pigs...
  81. ncbi Survival in breast cancer after nipple-sparing subcutaneous mastectomy and immediate reconstruction with implants: a prospective trial with 13 years median follow-up in 216 patients
    K P Benediktsson
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden
    Eur J Surg Oncol 34:143-8. 2008
    ..Validation of the oncological safety of nipple-sparing subcutaneous mastectomy and immediate reconstruction with implants (NSM) and of the outcome in patients with locoregional recurrences (LRRs) after this procedure...
  82. ncbi Biomarker assays in nipple aspirate fluid
    P Klein
    Genetics Branch, CCR National Cancer Institute, Bethesda, MD 20889, USA
    Breast J 7:378-87. 2001
    ..This technique may facilitate the identification and application of biomarkers for future breast cancer risk assessment and chemopreventive protocols...
  83. pmc Proteomic patterns of nipple aspirate fluids obtained by SELDI-TOF: potential for new biomarkers to aid in the diagnosis of breast cancer
    C P Paweletz
    Tissue Proteomics Unit, Division of Therapeutic Proteins, CBER, Food and Drug Administration, Bethesda, MD 20892, USA
    Dis Markers 17:301-7. 2001
    ....
  84. ncbi Proteomic analysis of nipple aspirate fluid using SELDI-TOF-MS
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, Columbia, MO 65212, USA
    Int J Cancer 114:791-6. 2005
    ....
  85. ncbi Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat
    L E Gray
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Ind Health 15:48-64. 1999
    ..V) kg-1 day-1 during sexual differentiation in rats induces female-like anogenital distance (AGD), retained nipples, cleft phallus with hypospadias, suprainguinal ectopic scrota/testes, a vaginal pouch, epididymal granulomas, and ..
  86. ncbi Detection of breast cancer biomarkers in nipple aspirate fluid by SELDI-TOF and their identification by combined liquid chromatography-tandem mass spectrometry
    Jianbo He
    Gonda UCLA Breast Cancer Research Laboratory, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Int J Oncol 30:145-54. 2007
    ....
  87. ncbi Sonographically guided mammotome excision of ducts in the diagnosis and management of single duct nipple discharge
    S Govindarajulu
    Breast Care Centre, Frenchay Hospital, Frenchay Park Road, Bristol BS16 1LE, United Kingdom
    Eur J Surg Oncol 32:725-8. 2006
    ..To describe our experience in the use of ultrasound guided mammotome in the diagnosis and management of single duct nipple discharge...
  88. ncbi Nipple-sparing mastectomy: critical assessment of 51 procedures and implications for selection criteria
    Anna M Voltura
    Department of Surgery, Division of Surgical Oncology, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Surg Oncol 15:3396-401. 2008
    ..The cosmetic result and high patient satisfaction of nipple-sparing mastectomy (NSM) has prompted further evaluation of the oncologic safety of this procedure...
  89. ncbi Anatomy of the nipple and breast ducts revisited
    Susan M Love
    Department of General Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Cancer 101:1947-57. 2004
    ..Increasing interest in the intraductal approach to the breast has necessitated revisiting the anatomy of the breast...
  90. pmc Impaired nipple development and parturition in LGR7 knockout mice
    Magda A M Krajnc-Franken
    N V Organon, Department of Pharmacology, 5340 BH Oss, The Netherlands
    Mol Cell Biol 24:687-96. 2004
    ..Moreover, a defect in parturition was observed, suggesting a role for LGR7 in the process of cervical ripening...
  91. ncbi Keratin 2e: a marker for murine nipple epidermis
    Bryon Mahler
    Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA
    Cells Tissues Organs 176:169-77. 2004
    ..The lack of appendages, altered stratification pattern and expression of a specialized keratin suggests that the murine nipple is an example of regionally specialized epidermis...
  92. ncbi History, physical and laboratory findings, and clinical outcomes of lactating women treated with antibiotics for chronic breast and/or nipple pain
    Anne Eglash
    University of Wisconsin Medical School, Meriter Hospital Outpatient Lactation Clinic, Mt Horeb, Wisconsin 53572, USA
    J Hum Lact 22:429-33. 2006
    ..Symptoms of deep breast aching, breast tenderness on palpation, and nipple lesions may be suggestive of a bacterial lactiferous duct infection. Treatment with antibiotics for 4 to 6 weeks may be appropriate...
  93. ncbi Nipple-sparing mastectomy update: one hundred forty-nine procedures and clinical outcomes
    Joseph P Crowe
    Department of General Surgery, Cleveland Clinic Foundation, 9500 Euclid Ave, A80, Cleveland, OH 44195, USA
    Arch Surg 143:1106-10; discussion 1110. 2008
    ..To describe our experience with patients who underwent the nipple-sparing mastectomy procedure developed and standardized at our institution and to report clinical outcomes for those patients with a breast cancer diagnosis...
  94. ncbi Mitochondrial DNA mutations in breast cancer tissue and in matched nipple aspirate fluid
    Weizhu Zhu
    Ellis Fischel Cancer Center, Department of Surgery, University of Missouri, Columbia, MO 65212, USA
    Carcinogenesis 26:145-52. 2005
    ..The high frequency of mtDNA mutations at polymorphic loci requires further investigation. Specific mtDNA mutations can be detected in a subset of NAF samples from women with breast cancer...
  95. ncbi Total skin-sparing mastectomy: complications and local recurrence rates in 2 cohorts of patients
    Elisabeth R Garwood
    Department of Surgery, Carol Franc Buck Breast Care Center, University of California at San Francisco, San Francisco, CA 94115, USA
    Ann Surg 249:26-32. 2009
    ..We sought to define the impact of surgical and reconstructive variables on complication rates and assess how changes in technique affect outcomes...
  96. ncbi Role of the size of the pedicle in reduction mammaplasty
    Wiktoria Hefter
    Department of Plastic and Hand Surgery, University Hospital of Northern Norway, Styrmannsveien 30, NO 9014 Tromsø, Norway
    Scand J Plast Reconstr Surg Hand Surg 40:13-8. 2006
    ..Twenty-four patients were relieved of pain and 83 reported improvement in their work and social life after operation. There were 47 women who were very satisfied and 33 who were satisfied with the results (total 80/101)...
  97. ncbi Correlation of nipple aspiration and ductal lavage cytology with histopathologic findings for patients before scheduled breast biopsy examination
    Kristine E West
    Department of Surgery, Loyola University Medical Center, 2160 S 1st Ave, Maywood, IL 60153, USA
    Am J Surg 191:57-60. 2006
    ..The purpose of this study was to correlate ductal lavage cytologic findings with the corresponding histology...
  98. ncbi Practical guidelines for repair of partial mastectomy defects using the breast reduction technique in patients undergoing breast conservation therapy
    Steven J Kronowitz
    Department of Plastic and Reconstructive Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Plast Reconstr Surg 120:1755-68. 2007
    ..The authors previously compared the local tissue rearrangement, breast reduction, and latissimus dorsi flap reconstruction techniques for repairing partial mastectomy defects and showed the benefits of breast reduction...
  99. ncbi Immediate prosthetic breast reconstruction: the ensured subpectoral pocket (ESP)
    Hugo D Loustau
    Department of Plastic Surgery, Hospital Italiano de Buenos Aires, University of Buenos Aires, School of Medicine, Gascon 450 C1181ACH, Buenos Aires, Argentina
    J Plast Reconstr Aesthet Surg 60:1233-8. 2007
    ..It allows the setting of bigger implants without previous tissue expansion while preventing implant displacement. In addition, it reduces emotional trauma on patients and lowers surgical costs...
  100. ncbi Can nipple-sparing mastectomy and immediate breast reconstruction with modified extended latissimus dorsi muscular flap improve the cosmetic and functional outcome of patients with breast cancer?
    Florian Fitzal
    World J Surg 32:499; author reply 500-1. 2008
  101. ncbi Oncological and aesthetic considerations of skin-sparing mastectomy
    Neill Patani
    London Breast Institute, The Princess Grace Hospital, London, W1U 5NY, UK
    Breast Cancer Res Treat 111:391-403. 2008
    ..Controversies including the impact of radiotherapy (RT) on immediate breast reconstruction (IBR), preservation of the nipple-areola complex (NAC) and the role of endoscopic mastectomy are also considered...

Research Grants50

  1. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
    ..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
  2. Prevention of Overfeeding During Infancy
    Kathryn G Dewey; Fiscal Year: 2010
    ..Infants will be randomized to the novel nipple or the conventional nipple, and a supply of bottles and nipples will be provided to the mother. Biweekly contact will be maintained with the mother throughout the study...
  3. Baby bottles that release no chemicals having estrogenic activity
    STUART YANIGER; Fiscal Year: 2012
    ..I, PPi will confirm preliminary data that that it is feasible to develop EA-Free silicones to manufacture EA-Free nipples for baby bottles...
  4. Breastmilk Transmission of HIV: Virology, Pharmacokinetics, and Adherence in BAN
    Susan A Fiscus; Fiscal Year: 2010
    ..Possible causes of increases in VL include breast problems (e.g. mastitis or cracked nipples), febrile illnesses, non-adherence to the treatment regimens, or poor bioavailability of the antiretrovirals...
  5. Feeding of Infants with Single Ventricle Heart Disease: Physiology and Behavior
    Britt Frisk Pados; Fiscal Year: 2012
    ..is to better understand what happens to these children when they are breastfed or fed using two different bottle nipples that offer different rates of milk flow...
  6. 3-D Computer Modeling for Optimizing Body Image following Breast Reconstruction
    Mia K Markey; Fiscal Year: 2013
    ..e., through automatic localization of fiducial points, i.e., anatomical landmarks such as nipples, sternal notch, etc.)...
  7. Development of a Breast Feeding Appliance for Infants with Cleft Lip and Palate
    Andrew Jardine; Fiscal Year: 2006
    ..be near impossible or certainly impractical to perform, and as a result the infants are bottle-fed with modified nipples. Expressed milk is then used to allow for the transfer of the mother's milk, which is generally acknowledged ..
  8. Neuron Phenotype Changes During Lactation
    Gloria Hoffman; Fiscal Year: 2005
    ..This proposal will determine if the pathways from the nipples to the hypothalamus initially regulate the TIDA neurons through a stimulatory relay in the peripenduncular n...
  9. SPINOHYPOTHALAMIC AND SPINOTELENCEPHALIC TRACTS
    GLENN GIESLER; Fiscal Year: 2000
    ..We will also test the hypothesis that SHT neurons are capable of providing sensory information originating in the nipples to hypothalamic neurons involved in the milk-ejection reflex...
  10. SUCKING DEVICE FOR FEEDING OF LOW-BIRTHWEIGHT INFANTS
    Barbara Medoff Cooper; Fiscal Year: 1993
    ..The present work is directed to developing specialized nipples and associated analysis software for studying the feeding behavior, development of sucking and swallowing of ..
  11. Protein Profiling in Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..abstract_text> ..
  12. Breast Cancer Prediction Using Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  13. Altered Breast Methylation after Low/Hi Dose Isoflavones
    Edward Sauter; Fiscal Year: 2005
    ..abstract_text> ..
  14. CHARACTERIZING SPECIALIZED CHEMOSENSORY NEURONS
    STEVEN MUNGER; Fiscal Year: 2002
    ..In addition, GC-D transgenic mice will be used to examine the ability of neonates to attach to nipples and suckle.
  15. DIETARY INTERVENTION--WOMEN HIGH RISK FOR BREAST CANCER
    Zora Djuric; Fiscal Year: 2002
    ..The use of biomarkers will allow to evaluate the cancer-protective effects of dietary modulation over a relatively short period of time. ..
  16. WEIGHT LOSS IN OBESE BREAST CANCER SURVIVORS
    Zora Djuric; Fiscal Year: 2002
    ..This study should be useful to determine certain psychosocial are associated with extent of weight loss, and in turn whether weight loss is associated with changes in selected markers of breast cancer risk. ..
  17. Mechanisms of Female Urinary Incontinence in Diabetes
    Margot Damaser; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  18. Computer-Aided Detection of Pulmonary Embolism on CT Pulmonary Angiography
    Chuan Zhou; Fiscal Year: 2007
    ..CAD will potentially reduce missed PEs and improve the chance of timely treatment of patients, thus reducing the mortality rate and speed up recovery from this condition. [unreadable] [unreadable]..
  19. Effects of Lycopene on High-Risk Prostatic Tissue
    Peter Gann; Fiscal Year: 2005
    ..abstract_text> ..
  20. Breast Cancer Prevention by Letrozole in High Risk Women
    Carol J Fabian; Fiscal Year: 2010
    ....
  21. Neoadjuvant Cytokine Immunotherapy by PLA Microspheres
    Michael Sabel; Fiscal Year: 2007
    ..I will pursue this area of investigation as a full-time faculty member, with full commitment from the Department of General Surgery and the Division of Surgical Oncology at the University of Michigan Medical Center. ..
  22. Breast Cancer Risk Biomarkers and Energy Balance
    CAROL FABIAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Primary Hormonal Therapy for DCIS of the Breast
    EUN SIL HWANG; Fiscal Year: 2008
    ..If patients could safely be spared from cancer progression while avoiding the morbidity of surgery and radiation for DCIS, the full benefit of early breast cancer detection could be realized. ..
  24. ROLE OF THE CELL CYCLE IN HYPERSENSITIVITY TO ESTRADIOL
    Richard Santen; Fiscal Year: 2008
    ..A clinical trial in women, which is designed to specifically demonstrate that high dose estrogen induces tumor regression through the mechanism of apoptosis will be conducted. ..
  25. FlaxSeed Lignan for Breast Cancer Chemoprevention
    CAROL FABIAN; Fiscal Year: 2007
    ..If positive, the results of this study will be critical to the design and implementation of a placebo-controlled Phase II prevention trial with Brevail and/or commercial flaxseed. [unreadable] [unreadable]..
  26. The 3rd Intraductal Approach to Breast Cancer Symposium
    Susan Love; Fiscal Year: 2003
    ..We are confident that this conference will have a positive impact on the direction and success of future learning and research using the Intraductal approach in the diagnosis, treatment, and prevention of breast cancer. ..
  27. WHO MULTICENTER GROWTH REFERENCE STUDY: U.S. SITE
    Kathryn Dewey; Fiscal Year: 2002
    ..The data will be pooled by WHO to create a new growth reference, applicable to all infants and children internationally. ..
  28. Genetic Susceptibility to Infection Related Cancer
    Ikuko Kato; Fiscal Year: 2005
    ..Secondary aims include to examine histopathological correlates of these polymorphisms and to determine whether selected environmental factors modify the above associations. ..
  29. BREAST CANCER STAGING WITH MRI PRIOR RE-EXCISION
    Susan Orel; Fiscal Year: 2001
    ..Correlation of MRI, mammographic, clinical, and pathological findings will generate a profile of patients at risk for occult, diffuse or multifocal disease who should undergo MRI prior to treatment recommendation. ..
  30. The 4th Intraductal Approach to Breast Cancer Symposium
    Susan Love; Fiscal Year: 2005
    ..Grants will be awarded at the end of the conference. We have found that this program design is most effective at increasing collaboration and ensuring that the research being done has the best chance for success. ..
  31. Hormonal Regulation of the Cervix During Pregnancy
    ORRIN SHERWOOD; Fiscal Year: 2006
    ..Treatment with RU 486 alone and in combination with exogenous relaxin will be done at term with relaxin-deficient rats. ..
  32. CHEMOPREVENTION FOR WOMEN AT HIGH RISK OF BREAST CANCER
    CAROL FABIAN; Fiscal Year: 2003
    ..The answer impacts on the entire future of breast cancer chemoprevention development efforts. ..
  33. The Breast Cancer 101 Conference
    Susan Love; Fiscal Year: 2003
    ..Furthermore, the partnership with the California BCRP and collaboration with Think Tank members further insures that the planning and carry-through for this conference will be done at the highest level. ..
  34. Bioinformatics for Protein Microarrays
    Richard Zangar; Fiscal Year: 2009
    ....
  35. Fourth International Conf. on Relaxin & Related Peptides
    ORRIN SHERWOOD; Fiscal Year: 2004
    ..Conference web site: http://www.life.uiuc.edu/relaxin2004/ ..
  36. Luminal Lipid Exposure, Genetics and Colon Cancer Risk
    Ikuko Kato; Fiscal Year: 2006
    ..In addition, accumulated dietary data and biological specimens will serve as an important resource for future research on other nutrient-gene interactions. ..
  37. Nutritional Risk Factors for Type 2 Diabetes in the Multiethnic Cohort
    Gertraud Maskarinec; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  38. MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSION
    Margot S Damaser; Fiscal Year: 2010
    ....
  39. 5th International Symposium on the Intraductal Approach to Breast Cancer
    Susan Love; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. REGULATION OF XENOBIOTIC-METABOLIZING CYP3A
    Richard Zangar; Fiscal Year: 2002
    ....
  41. The 2nd Santa Barbara Think Tank: The Normal Breast
    Susan Love; Fiscal Year: 2004
    ..Furthermore, the experienced members of the Think Tank planning committee further insures that the planning and carry-through for this conference will be done at the highest level. ..
  42. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  43. Effects of Soy on Estrogens in Breast Fluid and Urine
    Gertraud Maskarinec; Fiscal Year: 2010
    ..The NAF approach is the only way to learn more about the beneficial and adverse effects of soy directly in the female breast without applying invasive procedures to women without breast disease or surgery. ..
  44. Soy Consumption and Breast Tissue Proliferation
    Gertraud Maskarinec; Fiscal Year: 2006
    ....
  45. Breast Density, IGF-I, & Prolactin, in Four Populations
    Gertraud Maskarinec; Fiscal Year: 2004
    ..The statistical analysis will include mixed models to explore the relation between hormone levels and breast density while controlling for confounders and for clustering by study location. ..
  46. NESTED CASE CONTROL STUDY OF MAMMOGRAPHIC DENSITY
    Gertraud Maskarinec; Fiscal Year: 2002
    ....
  47. Microarray Analysis of Wounds
    AMY COLWELL; Fiscal Year: 2004
    ..We hypothesize these genes can be used to modulate the biology of adult wound healing. This first step will form our basis for developing treatment to induce scarless healing. ..
  48. Inflammatory Markers in a 2-Year Soy Intervention among Premenopausal Women
    Gertraud Maskarinec; Fiscal Year: 2008
    ..The statistical analysis will apply general linear models to compare the levels of inflammatory markers by soy intake, while taking into account the repeated measurement design. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. Phantoms for use in US and MR Elasticity Imaging
    ERNEST MADSEN; Fiscal Year: 2005
    ..Refined heterogeneous performance phantoms and anthropomorphic phantoms will be developed iteratively with assessments and advice from collaborators who are active researchers in ultrasound and MR elastography. ..
  50. MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUS
    GERTRUDE BUEHRING; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..