breast

Summary

Summary: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.

Top Publications

  1. ncbi Validating three-dimensional imaging of the breast
    Albert Losken
    Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta, GA 30308, USA
    Ann Plast Surg 54:471-6; discussion 477-8. 2005
  2. pmc Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    Emmanuelle Charafe-Jauffret
    Centre de Recherche en Cancerologie de Marseille, Laboratoire d Oncologie Moleculaire, UMR891 Inserm Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Cancer Res 69:1302-13. 2009
  3. pmc In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1253-70. 2003
  4. pmc Generation of breast cancer stem cells through epithelial-mesenchymal transition
    Anne Pierre Morel
    Centre Leon Berard, Lyon, France
    PLoS ONE 3:e2888. 2008
  5. ncbi Nonrigid registration using free-form deformations: application to breast MR images
    D Rueckert
    Division of Radiological Sciences and Medical Engineering, Guy s, King s, and St Thomas School of Medicine, King s College London, Guy s Hospital, London, UK
    IEEE Trans Med Imaging 18:712-21. 1999
  6. ncbi Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    Andrea H Bild
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Nature 439:353-7. 2006
  7. pmc EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    Celina G Kleer
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:11606-11. 2003
  8. pmc Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing
    Yonggui Fu
    State Key Laboratory for Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat Sen University, Higher Education Mega Center, Guangzhou 510006, P R China
    Genome Res 21:741-7. 2011
  9. pmc Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    Christina Scheel
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 145:926-40. 2011
  10. doi Long-term results of hypofractionated radiation therapy for breast cancer
    Timothy J Whelan
    McMaster University and Juravinski Cancer Centre, Hamilton, ON, Canada
    N Engl J Med 362:513-20. 2010

Detail Information

Publications294 found, 100 shown here

  1. ncbi Validating three-dimensional imaging of the breast
    Albert Losken
    Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta, GA 30308, USA
    Ann Plast Surg 54:471-6; discussion 477-8. 2005
    The potential to extrapolate accurate data from 3-dimensional (3D) images of the breast is enormous and will greatly improve our ability to qualitatively determine differences in shape, size, and contour...
  2. pmc Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    Emmanuelle Charafe-Jauffret
    Centre de Recherche en Cancerologie de Marseille, Laboratoire d Oncologie Moleculaire, UMR891 Inserm Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Cancer Res 69:1302-13. 2009
    ..Recombinant interleukin-8 (IL-8) increased mammosphere formation and the ALDEFLUOR-positive population in breast cancer cell lines. Finally, we show that ALDEFLUOR-positive cells are responsible for mediating metastasis...
  3. pmc In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1253-70. 2003
    ..The isolation and characterization of these stem cells should help elucidate the molecular pathways that govern normal mammary development and carcinogenesis...
  4. pmc Generation of breast cancer stem cells through epithelial-mesenchymal transition
    Anne Pierre Morel
    Centre Leon Berard, Lyon, France
    PLoS ONE 3:e2888. 2008
    ..The acquisition of these stem and tumorigenic characters is driven by EMT induction...
  5. ncbi Nonrigid registration using free-form deformations: application to breast MR images
    D Rueckert
    Division of Radiological Sciences and Medical Engineering, Guy s, King s, and St Thomas School of Medicine, King s College London, Guy s Hospital, London, UK
    IEEE Trans Med Imaging 18:712-21. 1999
    In this paper we present a new approach for the nonrigid registration of contrast-enhanced breast MRI. A hierarchical transformation model of the motion of the breast has been developed...
  6. ncbi Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    Andrea H Bild
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Nature 439:353-7. 2006
    ..Linking pathway deregulation with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogenic pathway signatures to guide the use of targeted therapeutics...
  7. pmc EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    Celina G Kleer
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:11606-11. 2003
    ..Here we investigate the functional role of EZH2 in cancer cell invasion and breast cancer progression...
  8. pmc Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing
    Yonggui Fu
    State Key Laboratory for Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat Sen University, Higher Education Mega Center, Guangzhou 510006, P R China
    Genome Res 21:741-7. 2011
    ..We used this strategy to explore the profiling of APA sites in two human breast cancer cell lines, MCF7 and MB231, and one cultured mammary epithelial cell line, MCF10A...
  9. pmc Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    Christina Scheel
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 145:926-40. 2011
    ..Conversely, disruption of autocrine signaling by added inhibitors of these pathways inhibits migration and self-renewal in primary mammary epithelial cells and reduces tumorigenicity and metastasis by their transformed derivatives...
  10. doi Long-term results of hypofractionated radiation therapy for breast cancer
    Timothy J Whelan
    McMaster University and Juravinski Cancer Centre, Hamilton, ON, Canada
    N Engl J Med 362:513-20. 2010
    The optimal fractionation schedule for whole-breast irradiation after breast-conserving surgery is unknown.
  11. pmc Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer
    Luciano Cascione
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 8:e55910. 2013
    Triple negative breast cancer (TNBC) is a heterogeneous disease at the molecular, pathologic and clinical levels...
  12. ncbi The PIK3CA gene is mutated with high frequency in human breast cancers
    Kurtis E Bachman
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Department of Oncology, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 3:772-5. 2004
    ..Here we show that thirteen of fifty-three breast cancers (25%) contain somatic mutations in PIK3CA, with the majority of mutations located in the kinase domain...
  13. ncbi Mammographic density and the risk and detection of breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada
    N Engl J Med 356:227-36. 2007
    Extensive mammographic density is associated with an increased risk of breast cancer and makes the detection of cancer by mammography difficult, but the influence of density on risk according to method of cancer detection is unknown.
  14. ncbi HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
    Marilyn A Owens
    IMPATH, Inc, Los Angeles, CA 90066, USA
    Clin Breast Cancer 5:63-9. 2004
    To analyze HER2 amplification in a large cohort of diagnostic breast cancer specimens, fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) were performed on the same specimens with use of Food and Drug Administration&..
  15. ncbi Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma
    Uche I Ezeh
    Program in Human Embryonic Stem Cell Biology, Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143 0556, USA
    Cancer 104:2255-65. 2005
    ..The current study was designed to identify whether expression of these 12p genes were elevated in seminoma relative to normal testis, and to determine whether elevated expression was unique to seminoma...
  16. pmc Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
    G Fritz
    Institute of Toxicology, Division of Applied Toxicology, University of Mainz, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    Br J Cancer 87:635-44. 2002
    ..relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours...
  17. ncbi Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells
    Josephine M Atienza
    Sequenom, Inc, 3595 John Hopkins Court, San Diego, CA 92121, USA
    Mol Cancer Ther 4:361-8. 2005
    ..laboratory has identified a single nucleotide polymorphism located in RAD21 as being significantly associated with breast cancer susceptibility...
  18. pmc Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts
    Catherine C Park
    Department of Radiation Oncology, University of California Comprehensive Cancer Center, San Francisco, CA 94143 1708, USA
    Cancer Res 68:4398-405. 2008
    ..g., AIIB2) enhance apoptosis and decrease growth in human breast cancer cells in three-dimensional laminin-rich extracellular matrix (lrECM) cultures and in vivo...
  19. pmc SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotype
    Poornima Bhat-Nakshatri
    Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
    BMC Cancer 10:411. 2010
    b>Breast cancer cells with CD44+/CD24- cell surface marker expression profile are proposed as cancer stem cells (CSCs). Normal breast epithelial cells that are CD44+/CD24- express higher levels of stem/progenitor cell associated genes...
  20. ncbi Stem cells in normal breast development and breast cancer
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Prolif 36:59-72. 2003
    The main focus of this review is the role of mammary stem cells in normal breast development and carcinogenesis...
  21. ncbi Gene expression profiling of breast cell lines identifies potential new basal markers
    E Charafe-Jauffret
    Marseille Cancer Institute, Laboratory of Molecular Oncology, Inserm Institut Paoli Calmettes, Marseille, France
    Oncogene 25:2273-84. 2006
    A better molecular characterization of breast cell lines (BCL) may help discover new markers to apply to tumour samples...
  22. doi Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer
    Sota Asaga
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Clin Chem 57:84-91. 2011
    ..We hypothesized that serum concentrations of miR-21, a biomarker increased in breast tumors, would correlate with the presence and extent of breast cancer.
  23. pmc Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues
    Kun Yuan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Histochem Cytochem 58:857-70. 2010
    ..PC were detected by immunofluorescence of cultured cells and breast tissues...
  24. pmc Gene expression profiles of estrogen receptor-positive and estrogen receptor-negative breast cancers are detectable in histologically normal breast epithelium
    Kelly Graham
    Genetics and Genomics Program and Department of Pathology, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA
    Clin Cancer Res 17:236-46. 2011
    Previously, we found that gene expression in histologically normal breast epithelium (NlEpi) from women at high breast cancer risk can resemble gene expression in NlEpi from cancer-containing breasts...
  25. ncbi Breast density as a predictor of mammographic detection: comparison of interval- and screen-detected cancers
    M T Mandelson
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    J Natl Cancer Inst 92:1081-7. 2000
    Screening mammography is the best method to reduce mortality from breast cancer, yet some breast cancers cannot be detected by mammography. Cancers diagnosed after a negative mammogram are known as interval cancers...
  26. pmc The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes
    N Al-Souhibani
    Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Oncogene 29:4205-15. 2010
    ..In this study we found that TTP expression was lower in invasive breast cancer cells (MDAMB231) compared with normal breast cell lines MCF12A and MCF-10...
  27. pmc Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk
    Celine M Vachon
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 21:1156-66. 2012
    Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility...
  28. doi Overexpression of LAPTM4B: an independent prognostic marker in breast cancer
    Min Xiao
    Department of Breast Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Baojian Road 6, Nangang District 150081, Harbin, China
    J Cancer Res Clin Oncol 139:661-7. 2013
    ..Our purpose was to evaluate the expression of LAPTM4B in breast carcinoma and its significance, which was not previously studied by others.
  29. doi Androgens and breast cancer
    Joanne Kotsopoulos
    Women s College Research Institute, Toronto, ON, Canada
    Steroids 77:1-9. 2012
    The role of androgens on breast cancer development and progression has not been fully elucidated...
  30. ncbi Comparative expression of the LINE-1 p40 protein in human breast carcinomas and normal breast tissues
    H L Asch
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Oncol Res 8:239-47. 1996
    ..LINE-1 (L1Hs) retrotransposons can act as insertional mutagens and are expressed in a variety of tumors, including breast cancer...
  31. pmc Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer
    Shibani Mukherjee
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Biol Ther 5:674-83. 2006
    ..GLI1, GLI2 and the 3 hedgehog ligands were identified for epithelial cells and stromal fibroblasts in benign breast and breast cancer...
  32. ncbi Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures
    Christy Hebner
    Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, CA, USA
    Annu Rev Pathol 3:313-39. 2008
    ..systems recreate the cardinal features of glandular epithelium in vivo and represent a valuable tool for modeling breast cancer initiation and progression in a structurally appropriate context...
  33. doi A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis
    Jean Philippe Pignol
    Department of Radiation Oncology, Sunnybrook Health Sciences Centre T2 144, 2075, Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    J Clin Oncol 26:2085-92. 2008
    Dermatitis is a frequent adverse effect of adjuvant breast radiotherapy. It is more likely in full-breasted women and when the radiation is distributed nonhomogeneously in the breast...
  34. ncbi MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer
    Constance D Lehman
    University of Washington Medical Center, Seattle, WA 98109, USA
    N Engl J Med 356:1295-303. 2007
    Even after careful clinical and mammographic evaluation, cancer is found in the contralateral breast in up to 10% of women who have received treatment for unilateral breast cancer...
  35. pmc Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells
    Zhengzhi Zou
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Autophagy 8:1798-810. 2012
    ..Here, we first revealed a clinically positive correlation between AURKA and autophagy-associated protein SQSTM1 in breast cancer and further demonstrated that AURKA regulated SQSTM1 through autophagy...
  36. ncbi Earlier onset of puberty in girls: relation to increased body mass index and race
    P B Kaplowitz
    Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Pediatrics 108:347-53. 2001
    ..Settings puberty data by comparing the age-normalized body mass index (BMI-ZS; a crude estimate of fatness) of girls who had breast or pubic hair development versus those who were still prepubertal, looking at the effects of age and race.
  37. ncbi FOXA1 expression in breast cancer--correlation with luminal subtype A and survival
    Sunil Badve
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    Clin Cancer Res 13:4415-21. 2007
    ..FOXA1 is expressed in breast cancer cells. It segregates with genes that characterize the luminal subtypes in DNA microarray analyses...
  38. pmc Unregulated miR-96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a
    Huanxin Lin
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 5:e15797. 2010
    ..In the current study, we report that expression of miR-96 was markedly upregulated in breast cancer cells and breast cancer tissues compared with normal breast epithelial cells (NBEC) and normal breast ..
  39. pmc E-cadherin expression in primary carcinomas of the breast and its distant metastases
    Paul J Kowalski
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Breast Cancer Res 5:R217-22. 2003
    Aberrant expression of E-cadherin has been associated with the development of metastases in patients with breast cancer...
  40. pmc Common variants in ZNF365 are associated with both mammographic density and breast cancer risk
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 43:185-7. 2011
    High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer...
  41. pmc Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast
    M Bauer
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
    Oncogene 29:1732-40. 2010
    b>Breast carcinoma invasion is associated with prominent alterations in stromal fibroblasts...
  42. ncbi Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis
    Scott P Fraser
    Neuroscience Solutions to Cancer Research Group, Department of Biological Sciences, Imperial College London, UK
    Clin Cancer Res 11:5381-9. 2005
    ..The purpose of this study was to investigate voltage-gated Na(+) channel (VGSC) expression and its possible role in human breast cancer.
  43. ncbi Diagnostic performance of digital versus film mammography for breast-cancer screening
    Etta D Pisano
    Department of Radiology, the Biomedical Research Imaging Center, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, USA
    N Engl J Med 353:1773-83. 2005
    Film mammography has limited sensitivity for the detection of breast cancer in women with radiographically dense breasts. We assessed whether the use of digital mammography would avoid some of these limitations.
  44. doi Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells
    David L Shattuck
    University of California Davis Cancer Center, Sacramento, CA 95817, USA
    Cancer Res 68:1471-7. 2008
    Her2 is overexpressed in 20% to 30% of breast tumors and correlates with reduced disease-free and overall patient survival...
  45. pmc Targeting breast stem cells with the cancer preventive compounds curcumin and piperine
    Madhuri Kakarala
    Division of Hematology Oncology, Department of Internal Medicine and Comprehensive Cancer Center, University of Michigan, 2150 Cancer Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Breast Cancer Res Treat 122:777-85. 2010
    ..the dietary polyphenols, curcumin, and piperine are able to modulate the self-renewal of normal and malignant breast stem cells, we examined the effects of these compounds on mammosphere formation, expression of the breast stem ..
  46. pmc Stromal effects on mammary gland development and breast cancer
    Bryony S Wiseman
    Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 296:1046-9. 2002
    b>Breast cancer manifests itself in the mammary epithelium, yet there is a growing recognition that mammary stromal cells also play an important role in tumorigenesis...
  47. ncbi Quantitative analysis of aromatase mRNA expression derived from various promoters (I.4, I.3, PII and I.7) and its association with expression of TNF-alpha, IL-6 and COX-2 mRNAs in human breast cancer
    Natsumi Irahara
    Department of Surgical Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Int J Cancer 118:1915-21. 2006
    ..4, I.3, PII and I.7) in axillary adipose tissue (AA), mammary adipose tissue (MA), breast tumor tissue (BT) and adjacent normal breast tissue (NB), and to study the relationship between aromatase mRNA ..
  48. pmc Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    Yohei Shimono
    Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304, USA
    Cell 138:592-603. 2009
    Human breast tumors contain a breast cancer stem cell (BCSC) population with properties reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed between human BCSCs and nontumorigenic cancer cells...
  49. doi CCL20 induces migration and proliferation on breast epithelial cells
    Santo Marsigliante
    Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Universita del Salento, Lecce, Italy
    J Cell Physiol 228:1873-83. 2013
    ..Since the microenvironment of breast cancer includes CCL20 chemokine, the purpose of this study was to determine whether CCL20 modulates the physiology ..
  50. pmc Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
    Hiroyuki Konishi
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 108:17773-8. 2011
    Biallelic inactivation of cancer susceptibility gene BRCA1 leads to breast and ovarian carcinogenesis...
  51. pmc PAM50 breast cancer subtyping by RT-qPCR and concordance with standard clinical molecular markers
    Roy R L Bastien
    The ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    BMC Med Genomics 5:44. 2012
    Many methodologies have been used in research to identify the "intrinsic" subtypes of breast cancer commonly known as Luminal A, Luminal B, HER2-Enriched (HER2-E) and Basal-like...
  52. ncbi The pressing need for better histologic-mammographic correlation of the many variations in normal breast anatomy
    T Tot
    Department of Pathology, Falun Central Hospital, Sweden
    Virchows Arch 437:338-44. 2000
    ..for a reevaluation of the working relationship between physicians dealing with the diagnosis and treatment of breast diseases...
  53. ncbi Angiogenesis-associated protein annexin II in breast cancer: selective expression in invasive breast cancer and contribution to tumor invasion and progression
    Meena R Sharma
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Mol Pathol 81:146-56. 2006
    Many advanced human tumors including breast cancer overproduce plasmin that is known to promote angiogenesis and metastasis. The mechanism of this effect is poorly understood...
  54. pmc Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
    B Elenbaas
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 15:50-65. 2001
    A number of genetic mutations have been identified in human breast cancers, yet the specific combinations of mutations required in concert to form breast carcinoma cells remain unknown...
  55. ncbi Breast cancer molecular subtypes respond differently to preoperative chemotherapy
    Roman Rouzier
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 11:5678-85. 2005
    Molecular classification of breast cancer has been proposed based on gene expression profiles of human tumors. Luminal, basal-like, normal-like, and erbB2+ subgroups were identified and were shown to have different prognoses...
  56. pmc Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer
    Ronald Wolf
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    Cancer Lett 277:101-7. 2009
    Human S100A7 (psoriasin) is considered a marker for specific stages of breast cancer. hS100A15 is almost identical to hS100A7 and difficult to discriminate...
  57. doi The application of laser-assisted indocyanine green fluorescent dye angiography in microsurgical breast reconstruction
    Martin I Newman
    Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA
    J Reconstr Microsurg 25:21-6. 2009
    ..The purpose of this study was to determine the value of this technology in microsurgical breast reconstruction...
  58. pmc Impact of aging on the biology of breast cancer
    Christopher C Benz
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Crit Rev Oncol Hematol 66:65-74. 2008
    b>Breast cancer is a heterogeneous malignancy; its age-specific incidence profile rises exponentially until menopause and increases more slowly thereafter, reflecting the superimposition of early-onset and late-onset breast cancer rates...
  59. pmc Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 163:315-26. 2003
    ....
  60. pmc Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions
    Nair Lopes
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto 4200 465, Portugal
    BMC Cancer 10:483. 2010
    b>Breast cancer is a heterogeneous disease associated with different patient prognosis and responses to therapy...
  61. doi Multicenter study of ultrasound real-time tissue elastography in 779 cases for the assessment of breast lesions: improved diagnostic performance by combining the BI-RADS®-US classification system with sonoelastography
    S Wojcinski
    Klinik fur Frauenheilkunde und Geburtshilfe, Franziskus Hospital, Bielefeld, Germany
    Ultraschall Med 31:484-91. 2010
    ..Our study evaluates whether sonoelastography improves the differentiation of benign and malignant breast lesions.
  62. doi Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung
    Derek C Radisky
    Mayo Clinic Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Proc Am Thorac Soc 5:316-22. 2008
    ....
  63. doi Expression of tenascin-C and its isoforms in the breast
    David S Guttery
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    Cancer Metastasis Rev 29:595-606. 2010
    ..The profile of isoforms expressed differs between cancers and normal breast, with the fully truncated TNC isoform being predominant in normal and benign tissues and higher molecular weight ..
  64. doi Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue
    Line L Haugan Moi
    Institute of Medicine, University of Bergen, Hormone Laboratory, Haukeland University Hospital, Bergen, Norway
    Clin Cancer Res 16:2176-86. 2010
    ..trial, dose reduction from 20 to 1 mg tamoxifen was associated with retained antiproliferative effect on breast cancer...
  65. pmc Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma of the breast
    Lesleyann Hawthorn
    Medical College of Georgia Cancer Center, 1120 15th St, Augusta, GA 30912, USA
    BMC Cancer 10:460. 2010
    A major challenge in the interpretation of genomic profiling data generated from breast cancer samples is the identification of driver genes as distinct from bystander genes which do not impact tumorigenesis...
  66. doi Intraoperative perfusion mapping with laser-assisted indocyanine green imaging can predict and prevent complications in immediate breast reconstruction
    Ewa Komorowska-Timek
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, Calif 94305 5148, USA
    Plast Reconstr Surg 125:1065-73. 2010
    Immediate breast reconstruction results in a superior cosmetic outcome...
  67. doi Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells
    Chia Hwa Lee
    Graduate Institute of Biomedical Technology, Taipei Medical University, No 250 Wu Hsing Street, Taipei, Taiwan
    J Natl Cancer Inst 102:1322-35. 2010
    ..cohort studies in the United States have indicated that active and passive smoking are associated with increased breast cancer risk...
  68. pmc FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis
    Gina M Bernardo
    Department of Pharmacology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Development 137:2045-54. 2010
    FOXA1, estrogen receptor alpha (ERalpha) and GATA3 independently predict favorable outcome in breast cancer patients, and their expression correlates with a differentiated, luminal tumor subtype...
  69. ncbi Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells
    S J Santner
    Barbara Ann Karmanlos Cancer Institute, Detroit, MI 48201, USA
    Breast Cancer Res Treat 65:101-10. 2001
    The MCF10 series of cell lines was derived from benign breast tissue from a woman with fibrocystic disease...
  70. doi Human endogenous retrovirus K triggers an antigen-specific immune response in breast cancer patients
    Feng Wang-Johanning
    Department of Veterinary Sciences and Michale E Keeling Center for Comparative Medicine and Research, The University of Texas M D Anderson Cancer Center, Houston, TX 78602 6621, USA
    Cancer Res 68:5869-77. 2008
    ..In this study, we determined the extent of HERV-K env expression in human breast cancer (BC) and whether both humoral and cell-mediated immunity against HERV-K can be found in BC patients...
  71. pmc The organizing principle: microenvironmental influences in the normal and malignant breast
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Differentiation 70:537-46. 2002
    ..How this context determines functional integrity, and how its loss can lead to malignancy, appears to have much to do with tissue structure and polarity...
  72. ncbi In vivo quantification of choline compounds in the breast with 1H MR spectroscopy
    Patrick J Bolan
    Center for Magnetic Resonance Research, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 50:1134-43. 2003
    This work describes a methodology for quantifying levels of total choline-containing compounds (tCho) in the breast using in vivo (1)H MR spectroscopy (MRS) at high field (4 Tesla)...
  73. pmc Telomere shortening occurs in subsets of normal breast epithelium as well as in situ and invasive carcinoma
    Alan K Meeker
    Department of Pathology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 164:925-35. 2004
    ..Using a direct telomere fluorescence in situ hybridization technique, we analyzed 114 invasive breast carcinomas, 29 carcinoma in situ lesions, 10 benign proliferative lesions, and different normal epithelial ..
  74. doi The nanomechanical signature of breast cancer
    Marija Plodinec
    Biozentrum and the Swiss Nanoscience Institute, University of Basel, 4056 Basel, Switzerland
    Nat Nanotechnol 7:757-65. 2012
    ..Here, we show using an indentation-type atomic force microscope (IT-AFM) that unadulterated human breast biopsies display distinct stiffness profiles...
  75. pmc Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer
    Duncan Sproul
    Breakthrough Breast Cancer Research Unit and Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 108:4364-9. 2011
    ..We investigated this possibility by analyzing promoter methylation in 19 breast cancer cell lines and 47 primary breast tumors...
  76. pmc Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines
    Patrica J Keller
    Department of Anatomy and Cellular Biology, Sackler School, Tufts University School of Medicine, Boston, MA 02111, USA
    Breast Cancer Res 12:R87. 2010
    Normal and neoplastic breast tissues are comprised of heterogeneous populations of epithelial cells involving various degrees of maturation and differentiation...
  77. pmc Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis
    Gulisa Turashvili
    Laboratory of Molecular Pathology, Institute of Pathology, Palacky University, Olomouc, Czech Republic
    BMC Cancer 7:55. 2007
    Invasive ductal and lobular carcinomas (IDC and ILC) are the most common histological types of breast cancer. Clinical follow-up data and metastatic patterns suggest that the development and progression of these tumors are different...
  78. ncbi Characterization of neoplastic and normal human breast tissues with in vivo (1)H MR spectroscopy
    K A Kvistad
    MR Center, Medical Division, University Hospital, N 7006 Trondheim, Norway
    J Magn Reson Imaging 10:159-64. 1999
    ..whether the detection of choline-containing compounds in in vivo (1)H magnetic resonance spectroscopy (MRS) of breast lesions is specific for carcinomas, whether a choline peak in in vivo (1)H MRS can be detected under physiological ..
  79. pmc Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
    Roshan Agarwal
    The University of Texas M D Anderson Cancer Center MDACC, Houston, Texas, USA
    Clin Cancer Res 15:3654-62. 2009
    We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling.
  80. doi Molecular detection of lymph node metastases in breast cancer patients: results of a multicenter trial using the one-step nucleic acid amplification assay
    Yasuhiro Tamaki
    Department of Breast and Endocrine Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 15:2879-84. 2009
    Accurate assessment of metastasis in sentinel lymph nodes (SLN) of breast cancer is important but involves a heavy workload for the pathologist...
  81. pmc Breast tissue composition and susceptibility to breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Room 10 415 610 University Ave, Toronto, ON, Canada M5G2M9
    J Natl Cancer Inst 102:1224-37. 2010
    b>Breast density, as assessed by mammography, reflects breast tissue composition. Breast epithelium and stroma attenuate x-rays more than fat and thus appear light on mammograms while fat appears dark...
  82. pmc Percent body fat at age 5 predicts earlier pubertal development among girls at age 9
    Kirsten Krahnstoever Davison
    Department of Human Development and Family Studies, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Pediatrics 111:815-21. 2003
    ..This study examines the causal direction of the relationship between weight status and pubertal timing in girls using a longitudinal sample of 183 white girls followed from ages 5 to 9...
  83. doi Multicentre evaluation of intraoperative molecular analysis of sentinel lymph nodes in breast carcinoma
    K L Snook
    Breast Unit, Royal Surrey County Hospital, and Postgraduate Medical School, University of Surrey, Guildford, UK
    Br J Surg 98:527-35. 2011
    Ideally, intraoperative sentinel lymph node (SLN) analysis in breast cancer should be automated, have high concordance with extensive histopathology, and be applicable in any hospital setting...
  84. doi Diffusion-weighted imaging of normal fibroglandular breast tissue: influence of microperfusion and fat suppression technique on the apparent diffusion coefficient
    Paul Baron
    University Medical Center Groningen, Department of Radiology, Groningen, The Netherlands
    NMR Biomed 23:399-405. 2010
    ..diffusion coefficient (ADC) values obtained with diffusion weighted imaging (DWI) of normal fibroglandular breast tissue was investigated...
  85. pmc Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells
    Jenny A Rudnick
    Graduate Program in Cell, Molecular and Developmental Biology Program, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24605. 2011
    ..Here we show that human breast fibroblasts are functionally heterogeneous with respect to tumor-promoting activity regardless of whether they ..
  86. doi Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling
    Scarlet F Brockmöller
    Institute of Pathology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Proteome Res 11:850-60. 2012
    ..On the basis of our recent findings of lipidomic changes in breast cancer, we investigated glycerol-3-phosphate acyltransferase (GPAM), a key enzyme in the lipid biosynthesis of ..
  87. pmc Aromatase, breast cancer and obesity: a complex interaction
    Serdar E Bulun
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Trends Endocrinol Metab 23:83-9. 2012
    Obesity has been associated with abnormally high expression of the enzyme aromatase in the breast, increased local estrogen production, and predisposition to breast hyperplasia and cancer...
  88. pmc Identification and pathway analysis of microRNAs with no previous involvement in breast cancer
    Sandra Romero-Cordoba
    Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica Mexico City, Mexico
    PLoS ONE 7:e31904. 2012
    microRNA expression signatures can differentiate normal and breast cancer tissues and can define specific clinico-pathological phenotypes in breast tumors...
  89. doi Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast
    H N Hilton
    Westmead Institute for Cancer Research, Sydney Medical School Westmead, University of Sydney at Westmead Millennium Institute, Westmead, New South Wales 2145, Australia
    Mol Cell Endocrinol 361:191-201. 2012
    Progesterone is critical in normal breast development and its synthetic derivatives are emerging as major drivers of breast cancer risk...
  90. pmc Relationship between mammographic density and breast cancer death in the Breast Cancer Surveillance Consortium
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    J Natl Cancer Inst 104:1218-27. 2012
    Women with elevated mammographic density have an increased risk of developing breast cancer. However, among women diagnosed with breast cancer, it is unclear whether higher density portends reduced survival, independent of other factors.
  91. pmc Development of a quantitative method for analysis of breast density based on three-dimensional breast MRI
    Ke Nie
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697, USA
    Med Phys 35:5253-62. 2008
    b>Breast density has been established as an independent risk factor associated with the development of breast cancer. It is known that an increase of mammographic density is associated with an increased cancer risk...
  92. pmc Mammary involution and breast cancer risk: transgenic models and clinical studies
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
    J Mammary Gland Biol Neoplasia 14:181-91. 2009
    ..Lobular involution is the process by which the breast epithelial tissue is gradually lost with aging of the mammary gland...
  93. doi Expression of melatonin receptor MT1 in cells of human invasive ductal breast carcinoma
    Karolina Jablonska
    Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland
    J Pineal Res 54:334-45. 2013
    ..The purpose of this study was to determine the distribution and the intensity of MT1 expression in breast cancer cells and to correlate it with clinicopathological factors...
  94. doi Estrogen receptor-α36 is involved in development of acquired tamoxifen resistance via regulating the growth status switch in breast cancer cells
    Guangliang Li
    Department of Surgical Oncology, The 1st Affiliated Hospital, School of Medicine, Zhejiang University, 79, Qingchun Road, Hangzhou, Zhejiang Province 310003, China
    Mol Oncol 7:611-24. 2013
    Acquired tamoxifen (TAM) resistance limits the therapeutic benefit of TAM in patients with hormone-dependent breast cancer. The switch from estrogen-dependent to growth factor-dependent growth is a critical step in this process...
  95. doi Monitoring apoptosis and Bcl-2 on circulating tumor cells in patients with metastatic breast cancer
    Jeffrey B Smerage
    Breast Oncology Program of the Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan Health and Hospital System, Ann Arbor, MI 48109, USA
    Mol Oncol 7:680-92. 2013
    Enumeration of circulating tumor cells (CTC) from whole blood permits monitoring of patients with breast carcinoma. Analysis of apoptosis & Bcl-2 expression in CTC might add additional prognostic and predictive information...
  96. pmc Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samples
    Fathi Elloumi
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med Genomics 4:54. 2011
    Genomic tests are available to predict breast cancer recurrence and to guide clinical decision making. These predictors provide recurrence risk scores along with a measure of uncertainty, usually a confidence interval...
  97. doi HLA-G expression in human breast cancer: implications for diagnosis and prognosis, and effect on allocytotoxic lymphocyte response after hormone treatment in vitro
    Xu He
    Core Laboratory, Sichuan Academy of Medical Sciences, Chengdu, Sichuan, People s Republic of China
    Ann Surg Oncol 17:1459-69. 2010
    The aim of this study is to investigate clinical implications of human leukocyte antigen-G (HLA-G) expression in breast cancer.
  98. pmc MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis
    Zheng Sheng Wu
    Department of Pathology, Anhui Medical University, Hefei, Anhui, People s Republic of China
    BMC Cancer 10:542. 2010
    MicroRNAs (miRNAs) play an important role in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. Detection of their expression may lead to identifying novel markers for breast cancer.
  99. doi Psychological reactions, quality of life, and body image after bilateral prophylactic mastectomy in women at high risk for breast cancer: a prospective 1-year follow-up study
    Yvonne Brandberg
    Department of Oncology Pathology, Karolinska Institutet, Radiumhemmet, Karolinska University Hospital, S 171 76, Stockholm, Sweden
    J Clin Oncol 26:3943-9. 2008
    ..emotional reactions (anxiety, depression), and quality of life in a sample of women having increased risk for breast cancer before and 6 months and 1 year after bilateral prophylactic mastectomy (BPM), and to compare preoperative ..
  100. ncbi Biexponential Signal Attenuation Analysis of Diffusion-weighted Imaging of Breast
    Takayuki Tamura
    Department of Radiology, Hiroshima Atomic Bomb Casualty Council, Health Management and Promotion Center, Naka ku, Hisroshima, Japan
    Magn Reson Med Sci 9:195-207. 2010
    ..In this study, we investigated the clinical utility of DWI for the breast by performing DWI using multiple b-factors on healthy volunteers and clinical subjects, analyzing the signal by ..
  101. pmc Reconstructive challenge of dermatofibrosarcoma protuberans in the female breast
    Tae Hwan Park
    Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    World J Surg Oncol 9:1. 2011
    ..But occurrence in the breast is extremely rare...

Research Grants86

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..focusing on cancer incidence overall, prostate cancer, colorectal cancer, pancreatic cancer, lunch cancer, breast cancer, and melanoma are now published. Analysis of NHL and leukemia is now underway...
  3. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..focusing on cancer incidence overall, prostate cancer, colorectal cancer, pancreatic cancer, lunch cancer, breast cancer, and melanoma are now published. Analysis of NHL and leukemia is now underway...
  4. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..to drug and radiation resistance, tumor angiogenesis, and progression of many cancer types including ovarian, breast, prostate, thyroid, colon, brain and hematological malignancies...
  5. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013
    ..years revealed that high vitamin D levels protect human body from many cancers, such as cancer of the colon, breast and prostate...
  6. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    ..reduces -Syn levels in the depressive rat model, WKY rat, and in endogenously expressing cells, such as the T-470 breast carcinoma cells...
  7. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Antagonizing UBC9 function in MCF-7 breast cancer cells transplanted in nude mice inhibited cell growth and increased apoptosis via Bcl-2 dependent ..
  8. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    ..the influence of vitamin A (retinol) and its active metabolite, all-trans retinoic acid (ATRA) on the incidence of breast and prostate cancers in humans...
  9. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..6 million people dying from cancer in 2007. More people in the US die of lung cancer than breast, colon, kidney, and prostate cancers combined...
  10. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..and/or promoter methylation are common mechanisms resulting in TRM9 loss in a panel of colon, head and neck, and breast cancer cells. SPECIFIC AIM2. To analyze the tumor suppressor / growth inhibitory pathways regulated by TRM9...
  11. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..juxtaposed to mammary gland ducts, combined with the known importance of collagenous matrix to the etiology of breast carcinoma and the up-regulation of col(V) in desmoplasia, have also prompted proposed studies into effects of 13(V)..
  12. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    Lung cancer is the number one cancer killer in the United States, exceeding breast, colorectal, prostate, and melanoma malignancies combined...
  13. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2013
    ..Increasing evidence supports the involvement of PRL in breast cancer, the leading type of cancer in women and the second leading cause (after lung cancer) of cancer death among ..
  14. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..new therapeutic strategies to prevent and treat osteoporosis with bone anabolic 1,25(OH)2D3 analogs, but could also shed light on the novel anticancer effects of vitamin D at sites such as the colon, skin, breast and
  15. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..community organizations, business and lay persons in partnering and collaborating to assess, address and improve breast feeding among African American women in Durham County...
  16. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..the gene encoding the splicing factor SF2/ASF is a proto-oncogene that can be activated by gene amplification in breast cancer. Drugs are being developed to correct aberrant splicing, e.g...
  17. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..secretion are hypertension, diabetes, obesity, osteoporosis, polycystic ovary syndrome and neoplasms of the colon, breast, ovary, and uterus...
  18. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    ..Over 28% of cancer diagnoses in US Veterans in 2009 were for prostate, breast, and ovarian carcinoma. However, these cancers are often asymptomatic in beginning stages of the disease...
  19. Metabolic mechanisms of antiestrogen resistance in breast cancer
    UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2013
    ..My long term career goal is to become an independent physician scientist who focuses on drug resistance in breast cancer and combines laboratory based mechanistic research and clinical trial design and implementation...
  20. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..participation rates in CRC screening are less than 30% for both genders, compared to rates of 70 to 80% for breast and cervical cancer screening, respectively (32)...
  21. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    ..from the intrinsic T-cell function, we have demonstrated that FOXP3 is the first X-linked tumor suppressor for breast cancer. FOXP3 directly targets critical oncogenes HER2/ErbB2 and SKP2 and a tumor suppressor gene p21...
  22. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..hepatitis B, occupational exposure reduction, comparative- and cost-effectiveness of mobile mammography, and breast, cervical, and colorectal cancer screening;3) geographical area - to include 4 contiguous San Francisco Bay Area ..
  23. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..Treatment with CXCR4-neutralizing antibodies reduces metastatic tumor formation in a mouse model for human breast cancer...
  24. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..Unfortunately, HT has a major drawback in that it causes proliferation of breast and endometrial cells...
  25. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ..Focus on normal mammary cells and cancer prevention. My lab has extensively studied the effects of vitamin D on breast cancer cells with the idea of targeting the vitamin D receptor (VDR) for cancer therapy...
  26. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..Brain metastasis indicates poor prognosis in several major malignancies. In breast cancer, brain metastasis is on the rise as progress is being made in controlling relapse to other sites...
  27. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..These include: the NCI Breast and Prostate Cancer Cohort Consortium (BPC3), the Pooling Project of Prospective Studies of Diet and Cancer, and ..
  28. Metabolic Adapation and Control of Lactation in Humans
    Morey W Haymond; Fiscal Year: 2010
    ..2. Lactate is the primary substrate for hexoneogenesis in the breast. 3. Glutamine and alanine both contribute to hexoneogenesis in the breast. 4...
  29. Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Pierre Alexandre Vidi; Fiscal Year: 2013
    ..in the K99 phase will examine the influence of basal polarity on DSB repair and nuclear organization in breast tissue samples...
  30. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..We will also examine these interactions in ER target tissues, including breast, uterine, bone, and macrophage cells...
  31. DNA Damage Checkpoint and Cancer
    Toru Ouchi; Fiscal Year: 2012
    ..knockout mouse to explore whether BAAT1 functions in tumor suppressor pathway in genetically defined models of breast cancer, and in environmental carcinogen-induced models of colorectal cancer...
  32. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ..Thus, the prognosis for this disease is more ominous than for many common types of cancer such as breast, prostate, and colon...
  33. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben-Jonathan; Fiscal Year: 2013
    Chemotherapy is the mainstay treatment for advanced breast cancer, but tumor resistance is a major obstacle that results in treatment failure...
  34. Roles of NF-kB/Rel in the pathogenesis of breast cancer
    Gail E Sonenshein; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Breast cancer incidence has been increasing over the past 50 years, and is now the second leading cause of death among American women...
  35. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
    ..Examples of epigenetic regulation of ER2 are seen in breast and prostate cancer where ER2 expression has been correlated with changes in methylation...
  36. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    ..using validated questionnaire instruments in humans undergoing chemotherapy and/or radiation therapy for breast cancer, 2) dissect parameters of this pathway pre-clinically, specifically testing a) radiation dose-response, b) ..
  37. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..choroidal neovascularization model and also analyzing tumor angiogenesis in a orthotopic xenograft model of breast cancer...
  38. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..Platinum now also shows promise for triple-negative breast cancer...
  39. Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma
    Warren S Warren; Fiscal Year: 2010
    ..of melanoma is the second most common reason for cancer malpractice claims in the United States (after breast cancer)...
  40. Intermediary Metabolism, Histone Acetylation, and Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2013
    ..We will also determine whether the inhibition of ACC or the activation of AMPK in human breast cancer MCF7 cells results in increased acetylation of histones, altered transcriptional regulation, and increased ..
  41. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..Overall, reproductive experience-induced shifts in endocrine activities may affect endocrine-related diseases and behaviors later in adulthood, i.e. breast cancer, autoimmune diseases, and postpartum mood disorders.
  42. INTERACTION OF THE ESTROGEN RECEPTOR WITH DNA
    ANN NARDULLI; Fiscal Year: 2013
    ..are widely used in regulating fertility, alleviating postmenopausal symptoms, and preventing and treating breast cancer...
  43. Novel CTD inhibitors with synthetic lethality to oncogenic Ras for cancer therapy
    Bingliang Fang; Fiscal Year: 2013
    ..on NCI-60 cell lines showed that oncrasins are active against several cell lines derived from lung, colon, breast, ovary, and kidney cancers and oncrasin-60 lies outside the category of adequately studied classes of antitumor ..
  44. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..frozen plasma and DNA, and tumor tissue to address hypotheses regarding cancers of the prostate, colon and rectum, breast, and brain (glioma)...
  45. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
    ..allele of the ATM (ataxia-telangiectasia mutated) gene and ATM heterozygotes have an increased risk of developing breast cancer...
  46. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..Aim 3 will determine whether transplatin interferes with the growth inhibitory action of cisplatin against breast and prostate cancer tumors in severe combined immunodeficient (SCID) mice...
  47. Tumor Cell Arrest and Adhesion in the Microcirculation
    Bingmei M Fu; Fiscal Year: 2013
    ..For example, breast cancer cells preferentially arrest in the small blood vessels of the lungs, liver, brain and bones...
  48. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
    ..Finally, these recent developments will be implemented in breast cancer research analyzing 177 histologically and clinically characterized tumor samples...
  49. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
    ..during pregnancy, including consumption of a HF diet, may induce methylation of PcTGs/TSGs in the offspring's breast. Interestingly, women at high risk of developing breast cancer exhibit methylation of PcGTs and TSGs...
  50. Exploratory Studies on the Anti-Breast Cancer Function of Bamboo Extract
    Jun Panee; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Breast cancer is the most prevalent cancer among women in the United States...
  51. Parental age at birth and risk of adult-onset cancer in female offspring
    Yani Lu; Fiscal Year: 2013
    ..To date, the association with parental age has only been studied for breast cancer, prostate cancer and hematological malignancies...
  52. MECHANISM OF DRUG TRANSPORT IN LUNG CANCER CELLS
    Sanjay Awasthi; Fiscal Year: 2011
    ..which is overexpressed in a number of types of cancers (lung, ovary, prostate, skin), but not in all types (breast, liver)...
  53. Evolution of the Immune Response to Cytomegalovirus Transmitted via Breast Milk
    Lynn Puddington; Fiscal Year: 2010
    ..HCMV infection also occurs postnatally in newborns via viral transmission in breast milk...
  54. Addressing Psychosocial Disparities in Rural Hispanic Cancer Survivors
    Rachel M Ceballos; Fiscal Year: 2013
    ..Among Hispanics, the 5-year cause-specific survival rate across all stages of female reproductive cancers (breast, uterine, cervical, ovarian) has been steadily improving. As the population of U.S...
  55. Iron, NO, and Lipid Peroxide in Photodynamic Therapy
    ALBERT GIROTTI; Fiscal Year: 2013
    ..We recently discovered that NO is overproduced by ALA/light-stressed breast tumor cells due to rapid and prolonged upregulation of inducible NOS and that this substantially increases cell ..
  56. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..of their potential side effects, the most critical of which are the effects of estrogen on the uterus and the breast. However, estrogen insufficiency contributes to post-menopausal decline in sexual desire that can lead to female ..
  57. Erythropoietin in Non-Erythroid Cells: Function and Regulation
    Josef T Prchal; Fiscal Year: 2013
    ..and transcripts of EPO and/or its receptor (EPOR) genes are found in brain, endothelium, hematopoietic stem cells, breast, ovary, testes, and other tissues...
  58. Health Care Disparities in the Pacific Islands Pacific Regional Medical Conferenc
    SAIED SAFABAKHSH; Fiscal Year: 2011
    ..Certain cancers of head, neck, lung and breast are well-established to be more prevalent in this community compared to the U.S. mainland...
  59. The role of LKB1 in the maintenance of genomic stability.
    Zhi Xiang Xu; Fiscal Year: 2013
    ..are also found in cancer patients without PJS, including sporadic lung adenocarcinoma (common), ovarian cancer, breast cancer, pancreatic cancer, and biliary adenocarcinoma (rare)...
  60. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ..A-1 (Apo A-1) and Apo B100), as well as long-term use of statins in relation to risk of total invasive cancer and breast, colorectal and endometrial cancer...
  61. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..This conversion is effective in the brain but not in the uterus, breast, or the pituitary gland...
  62. Flame Retardant and Adverse Perinatal Outcome (FRAPO)
    Morgan R Peltier; Fiscal Year: 2013
    ..As a result, North Americans have the highest blood and breast milk concentrations of PBDEs anywhere in the world. PBDEs are present in the plasma of almost all pregnant women...
  63. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..ultimate goal of this proposal is to gain a full understanding of the mechanisms by which tea catechins inhibit breast carcinogenesis in humans...
  64. Etiology of breast development in the BCERC network: role of socioeconomic status
    DEJANA K BRAITHWAITE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Etiology of breast development in the BCERC network: role of socioeconomic status Dejana Braithwaite, Robert A...
  65. Effects of herbs on transcription and cell proliferation
    Dale Leitman; Fiscal Year: 2003
    Multiple lines of evidence indicate that estrogens promote breast cancer, Selective estrogen receptor modulators (SERMs), such as tamoxifen are first-line drugs used as adjuvant therapy for preventing recurrences and reducing mortality ..
  66. Molecular Epidemiology of Secondary Lung Cancer
    Peter Shields; Fiscal Year: 2007
    Several studies indicate that women with breast cancer who undergo radiotherapy are susceptible to secondary lung cancer, whether they are smokers or nonsmokers...
  67. DETERMINATION OF A NEW GROWTH FACTOR IN BREAST MILK
    DAVID TAPPER; Fiscal Year: 1992
    b>Breast cancer is the most frequent type of cancer in women in Western societies and in the United States has shown an alarming increase in incidence from 87/100,000 to 104/100,000 within the last five years...
  68. Development and Validation of a Panel of Breast Cancer for the Early Diagnosis of
    FELIX RODOLFO FERNANDEZ MADRID; Fiscal Year: 2010
    Development and validation of a panel of breast cancer autoantigens for the early diagnosis of breast cancer Abstract Detection of the early stages of breast cancer is one of the pillars of successful therapy and the identification of ..
  69. Web-based Patient-Reported Outcomes (PRO) System for Breast Cancer Survivors
    JOHN CHRISTOPHER WEISS; Fiscal Year: 2010
    ..Title: "Web-based Patient-Reported Outcomes (PRO) System for Breast Cancer Survivors" The issues surrounding the ongoing care, support, and surveillance of breast cancer survivors ..
  70. A Dual Resolution Cone Beam CT System for 3-D Breast Imaging
    Chris C Shaw; Fiscal Year: 2010
    ..of new imaging modalities, x-ray mammography remains the main tool for screening, diagnosis and management of breast cancers...
  71. A Dual Resolution Cone Beam CT System for 3-D Breast Imaging
    Chris Shaw; Fiscal Year: 2007
    ..of new imaging modalities, x-ray mammography remains the main tool for screening, diagnosis and management of breast cancers...
  72. Molecular Analysis of NeoAdjuvant Platinum in Triple Negative Breast Cancer
    MARK DANIEL contact PEGRAM; Fiscal Year: 2010
    ..The Challenge and Potential Impact: With a global incidence of 1,151,298 each year, breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death (465,000/year) in ..
  73. A Neoadjuvant Trial of Anastrazole and A Novel SRC Inhibitor, AZD0530, for LABC
    JOYCE MARIE contact SLINGERLAND; Fiscal Year: 2010
    Estrogen receptor 1 (ER) is expressed in 70% of new breast cancers but de novo and acquired resistance to tamoxifen or aromatase inhibitors (AI) limit their efficacy...
  74. Green tea catechins in precancerorus prevention
    HWA CHAIN WANG; Fiscal Year: 2009
    ..identify effective constituents and mechanisms of green tea catechins (GTCs) in precancerous prevention of human breast cancers associated with long-term exposures to environmental carcinogens...
  75. Oral contraceptive use by formulation and breast cancer risk by subtype
    DIANA SM BUIST; Fiscal Year: 2010
    ..have ever used oral contraceptives (OCs) during their reproductive lives and there is a modest increased risk of breast cancer associated with recent use of OCs among young women, yet there have been few studies that have assessed the ..
  76. BREAST CANCER METASTASES TO BONE--ROLE OF PTHRP & TGFB
    Theresa Guise; Fiscal Year: 2000
    b>Breast cancer metastasizes to the skeleton more frequently than any other tumor type causing the devastating complications of hypercalcemia, pain, fracture and nerve compression syndromes...
  77. Spatial, Temporal, Social Disparities in Breast Cancer
    Mario Schootman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Screening for breast cancer reduces mortality...
  78. Coexpression of EGFRvlll/ErbB2 in Human Breast Cancer
    Careen Tang; Fiscal Year: 2005
    ..Our pilot results demonstrated that 70 percent (103/147) of invasive breast cancer express EGFRvIII...
  79. A novel therapy for HER2 positive hormone refractory breast cancer
    Anne W Hamburger; Fiscal Year: 2010
    ..The development of hormone resistance in breast cancer is a significant clinical problem...
  80. Development of a 3D mammotomograph with novel techniques to overcome limitations
    Randolph L McKinley; Fiscal Year: 2010
    ..center collaborators with the experience obtained from our SBIR Phase I project to provide a 3rd generation 3D breast CT scanner suitable for a planned patient trial...
  81. Breast Adipose Participates to Bioactivate Vitamin D and Inhibit Breast Cancer
    Glendon M Zinser; Fiscal Year: 2010
    ..Specifically, the contribution of mammary adipose, which accounts for ~80% of the breast, to vitamin D3 synthesis, signaling, and growth inhibition of mammary epithelial cells has yet to be investigated...
  82. Chronic Cadmium Exposure Promotes Breast Cancer Progression
    Maggie C Louie; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Breast cancer is among one of the most common cancers that occur in women in the United States;it accounts for one in four female cancers, making it one of the most important cancers in the Western ..
  83. MicroRNA Signature of Tamoxifen Resistance in Breast Cancer
    Sarmila Majumder; Fiscal Year: 2010
    ..b>Breast cancer is the second leading cause of death in women today and one of the most common cancers among women in North ..
  84. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005
    Despite considerable research, the relationship between cigarette smoking and breast cancer remains controversial...
  85. BREAST TUMOR PROXIMAL STROMA INTERACTION AND AROMATASE
    Serdar Bulun; Fiscal Year: 2000
    ..Local estrogen production in the breast has been implicated in the growth of breast cancers...
  86. Cyr61-induced breast cancer: Clinical relevance and therapeutic development
    Ruth Lupu; Fiscal Year: 2010
    ..protein 61 (Cyr61), a member of the CCN protein family, is overexpressed in a biologically aggressive subset of breast carcinomas. Moreover, forced expression of Cyr61 in breast cells promotes tumor formation in nude mice...