peritoneal cavity

Summary

Summary: The space enclosed by the peritoneum. It is divided into two portions, the greater sac and the lesser sac or omental bursa, which lies behind the STOMACH. The two sacs are connected by the foramen of Winslow, or epiploic foramen.

Top Publications

  1. ncbi The influence of BCR density on the differentiation of natural poly-reactive B cells begins at an early stage of B cell development
    Ying Xing
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Mol Immunol 46:1120-8. 2009
  2. pmc The peritoneal cavity B-2 antibody repertoire appears to reflect many of the same selective pressures that shape the B-1a and B-1b repertoires
    Andre M Vale
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:6085-95. 2010
  3. ncbi The ability of nisin F to control Staphylococcus aureus infection in the peritoneal cavity, as studied in mice
    A M Brand
    Department of Microbiology, University of Stellenbosch, Stellenbosch, South Africa
    Lett Appl Microbiol 51:645-9. 2010
  4. ncbi The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors
    D R Moritz
    Department of Pathology, University Hospital Zurich, Switzerland
    J Immunol 161:4866-74. 1998
  5. ncbi Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
    R C Rickert
    Institute for Genetics, University of Cologne, Germany
    Nature 376:352-5. 1995
  6. ncbi Cytokine-dependent inflammatory cell recruitment patterns in the peritoneal cavity of mice exposed to the parasitic nematode Brugia malayi
    Andrew S MacDonald
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Med Microbiol Immunol 192:33-40. 2003
  7. ncbi Submucosal endoscopy with mucosal flap safety valve (SEMF) technique: a safe access method into the peritoneal cavity and mediastinum
    Kazuki Sumiyama
    Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
    Minim Invasive Ther Allied Technol 17:365-9. 2008
  8. ncbi Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots
    Simon Berberich
    Institute of Immunology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    J Immunol 180:2196-203. 2008
  9. ncbi Prevention of adhesion formation in a laparoscopic mouse model should combine local treatment with peritoneal cavity conditioning
    M M Binda
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Hum Reprod 24:1473-9. 2009
  10. pmc Mast cell repopulation of the peritoneal cavity: contribution of mast cell progenitors versus bone marrow derived committed mast cell precursors
    Maria Celia Jamur
    Department of Cell and Molecular Biology and Pathogenic Bioagents, University of Sao Paulo, Ribeirao Preto, Brazil
    BMC Immunol 11:32. 2010

Detail Information

Publications249 found, 100 shown here

  1. ncbi The influence of BCR density on the differentiation of natural poly-reactive B cells begins at an early stage of B cell development
    Ying Xing
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Mol Immunol 46:1120-8. 2009
    ..More importantly, our data suggests that the influence by receptor expression on the differentiation of natural poly-reactive B cells begins at an early stage of B cell development...
  2. pmc The peritoneal cavity B-2 antibody repertoire appears to reflect many of the same selective pressures that shape the B-1a and B-1b repertoires
    Andre M Vale
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:6085-95. 2010
    ..assess the extent and nature of somatic categorical selection of CDR-3 of the Ig H chain (CDR-H3) content in peritoneal cavity (PerC) B cells, we analyzed the composition of V(H)7183DJCμ transcripts derived from sorted PerC B-1a, B-1b,..
  3. ncbi The ability of nisin F to control Staphylococcus aureus infection in the peritoneal cavity, as studied in mice
    A M Brand
    Department of Microbiology, University of Stellenbosch, Stellenbosch, South Africa
    Lett Appl Microbiol 51:645-9. 2010
    ..To determine the ability of nisin F to control systematic infection caused by Staphylococcus aureus, using C57BL/6 mice as a model...
  4. ncbi The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors
    D R Moritz
    Department of Pathology, University Hospital Zurich, Switzerland
    J Immunol 161:4866-74. 1998
    ....
  5. ncbi Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
    R C Rickert
    Institute for Genetics, University of Cologne, Germany
    Nature 376:352-5. 1995
    ..2)...
  6. ncbi Cytokine-dependent inflammatory cell recruitment patterns in the peritoneal cavity of mice exposed to the parasitic nematode Brugia malayi
    Andrew S MacDonald
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Med Microbiol Immunol 192:33-40. 2003
    ..adult parasites drive the recruitment of eosinophils and macrophages after implant into the murine peritoneal cavity whereas Th1-inducing microfilaria do not...
  7. ncbi Submucosal endoscopy with mucosal flap safety valve (SEMF) technique: a safe access method into the peritoneal cavity and mediastinum
    Kazuki Sumiyama
    Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
    Minim Invasive Ther Allied Technol 17:365-9. 2008
    ..The methods and technology growing from this concept may minimize trauma from surgical access to the peritoneal cavity by completely eliminating body surface incisions...
  8. ncbi Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots
    Simon Berberich
    Institute of Immunology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    J Immunol 180:2196-203. 2008
    The constitutive migration of B cells from the circulation into the peritoneal cavity and back is essential for peritoneal B cell homeostasis and function...
  9. ncbi Prevention of adhesion formation in a laparoscopic mouse model should combine local treatment with peritoneal cavity conditioning
    M M Binda
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Hum Reprod 24:1473-9. 2009
    ..This process can be enhanced by factors derived from the peritoneal cavity such as mesothelial cell hypoxia (pneumoperitoneum with pure CO(2)), reactive oxygen species (..
  10. pmc Mast cell repopulation of the peritoneal cavity: contribution of mast cell progenitors versus bone marrow derived committed mast cell precursors
    Maria Celia Jamur
    Department of Cell and Molecular Biology and Pathogenic Bioagents, University of Sao Paulo, Ribeirao Preto, Brazil
    BMC Immunol 11:32. 2010
    ..This study was undertaken to determine the mast cell response in the peritoneal cavity and bone marrow during repopulation of the peritoneal cavity in rats.
  11. ncbi Tryptophan consumption and indoleamines production by peritoneal cavity macrophages
    E Martins
    Department of Histology and Embryology, Institute of Biomedical Sciences, University of São Pauolo, Brazil
    J Leukoc Biol 75:1116-21. 2004
    ..So, we evaluated the rate of tryptophan consumption and melatonin and serotonin production in peritoneal cavity-isolated macrophages and the effect of IFN-alpha and -gamma, lipopolysaccharide (LPS), and phorbol myristate ..
  12. ncbi The open peritoneal cavity: etiology correlates with the likelihood of fascial closure
    Betty J Tsuei
    Section of Trauma and Critical Care, Department of Surgery, University of Kentucky, Lexington, Kentucky 40536 0084, USA
    Am Surg 70:652-6. 2004
    ..In our study, the number of operations and likelihood of abdominal closure appears to correlate with the etiology of the underlying disease requiring use of laparostomy...
  13. ncbi SILS (single incision laparoscopic surgery) - new surgical approach to peritoneal cavity
    A Budzynski
    Jagiellonian University Medical College, 2nd Department of General Surgery, Krakow, Poland
    Adv Med Sci 56:18-24. 2011
    ..During the last years we can observe an intense development of surgical technique minimizing the access to peritoneal cavity to just one small incision, most frequently localized in the umbilicus.
  14. ncbi CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution
    Erin Drew
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Immunity 22:43-57. 2005
    ..Our data provide clear-cut evidence for a hematopoietic function for CD34 and suggest that it acts as a negative regulator of cell adhesion...
  15. ncbi On sample size of the kruskal-wallis test with application to a mouse peritoneal cavity study
    Chunpeng Fan
    Department of Biostatistics and Programming, sanofi aventis BX2 416A, 200 Crossing Boulevard, P O Box 6890, Bridgewater, New Jersey 08807 0890, USA
    Biometrics 67:213-24. 2011
    ..A mouse peritoneal cavity study is used to demonstrate the application of the methods.
  16. pmc Streptococcus pneumoniae PstS production is phosphate responsive and enhanced during growth in the murine peritoneal cavity
    C J Orihuela
    The University of Texas Medical Branch at Galveston, Department of Microbiology and Immunology, Galveston, Texas 77555 1019, USA
    Infect Immun 69:7565-71. 2001
    ..was used to identify a Streptococcus pneumoniae gene with enhanced transcription during growth in the murine peritoneal cavity. Northern dot blot analysis and comparative densitometry confirmed a 1...
  17. ncbi Less impaired cell-mediated immune response in the murine peritoneal cavity after CO(2) pneumoperitoneum
    Kyuzo Fujii
    First Department of Surgery, Oita Medical University, 1 1 Idaigaoka, Hasama machi, 879 5593 Oita, Japan
    Surg Today 33:833-8. 2003
    ..changes in the populations of peritoneal T lymphocytes and natural killer (NK) cells after CO(2) pneumoperitoneum and laparotomy to clarify whether pneumoperitoneum affects cell-mediated immune responses in the peritoneal cavity.
  18. ncbi Fate of infective larvae of Brugia malayi in the peritoneal cavity of Mastomys natalensis and Meriones unguiculatus
    P K Murthy
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Folia Parasitol (Praha) 44:302-4. 1997
    ..None of the infected M. natalensis had adult worms in the peritoneal cavity; very few degenerating L3 surrounded by peritoneal cells were recovered 7 and 15 DPI...
  19. ncbi Rapid quantitative detection of carcinoembryonic antigen-expressing free tumor cells in the peritoneal cavity of gastric-cancer patients with real-time RT-PCR on the lightcycler
    H Nakanishi
    Laboratory of Pathology, Aichi Cancer Center Research Institute, Nagoya Aichi, Japan
    Int J Cancer 89:411-7. 2000
    Detection of free cancer cells in the peritoneal cavity by RT-PCR using carcinoembryonic antigen (CEA) as a target gene is a more sensitive predictor of peritoneal dissemination than conventional cytology in gastric-cancer patients...
  20. ncbi Disproportionally low clearance of macromolecules from the plasma to the peritoneal cavity in a mouse model of peritoneal dialysis
    Anna Rippe
    Department of Nephrology, University Hospital of Lund, S 211 85 Lund, Sweden
    Nephrol Dial Transplant 22:88-95. 2007
    ..This study was performed to establish a model for quantitative measurements of a number of basic peritoneal transport parameters, particularly transperitoneal clearances (Cl) of macromolecules, during mouse peritoneal dialysis...
  21. ncbi Neutrophil and macrophage responses to inflammation in the peritoneal cavity of rainbow trout Oncorhynchus mykiss. A light and electron microscopic cytochemical study
    A Afonso
    Institute of Molecular and Cellular Biology, University of Porto, Portugal
    Dis Aquat Organ 34:27-37. 1998
    The neutrophil and macrophage responses that accompany inflammation were studied in the peritoneal cavity of rainbow trout Oncorhynchus mykiss using light and electron microscopic cytochemistry...
  22. pmc The differential imaging features of fat-containing tumors in the peritoneal cavity and retroperitoneum: the radiologic-pathologic correlation
    Na Young Shin
    Department of Radiology, Severance Hospital, Yonsei University School of Medicine, Seoul, Korea
    Korean J Radiol 11:333-45. 2010
    ..Classifying lesions in terms of the necessity of performing surgical treatment can provide important information to clinicians, and this is the one of a radiologist's key responsibilities...
  23. ncbi Molecular profiling of murine sensory neurons in the nodose and dorsal root ganglia labeled from the peritoneal cavity
    Pieter J Peeters
    Department of Internal Medicine, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Physiol Genomics 24:252-63. 2006
    ..calcium channels; and transient receptor potential cation channels present in afferents projecting to the peritoneal cavity. Our genome-wide expression profiling data provide novel insight into molecular signatures that underlie ..
  24. ncbi Expression of defensin antimicrobial peptides in the peritoneal cavity of patients on peritoneal dialysis
    K H Zarrinkalam
    Department of Renal Medicine, Royal Adelaide Hospital, South Australia, Australia
    Perit Dial Int 21:501-8. 2001
    OBJECTIVE: To investigate the expression and regulation of defensins in the peritoneal cavity of peritoneal dialysis (PD) patients...
  25. ncbi Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity
    Craig A Poland
    Safenano, Institute of Occupational Medicine, Riccarton, Edinburgh, UK
    Nanotoxicology 6:899-911. 2012
    ..This may have important implications when considering the hazard posed by fibrous nanomaterials and their regulation in workplaces...
  26. ncbi Adult granulosa cell tumor presenting as metastases to the pleural and peritoneal cavity
    Nalini Gupta
    Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Diagn Cytopathol 40:912-5. 2012
    ..A precise diagnosis in such a case may be possible on serous body fluid cytology with a combined clinical and cytopathologic approach...
  27. pmc The local inflammatory responses to infection of the peritoneal cavity in humans: their regulation by cytokines, macrophages, and other leukocytes
    Marien Willem Johan Adriaan Fieren
    Department of Internal Medicine, Erasmus Medical Center, Centrumlocatie, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mediators Inflamm 2012:976241. 2012
    ....
  28. ncbi Lymphoid organs for peritoneal cavity immune response: milky spots
    Reina E Mebius
    Department of Molecular Cell Biology and Immunology, VUMC, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Immunity 30:670-2. 2009
    Milky spots are located in the omentum of the peritoneal cavity and their classification as lymphoid organs has been debated. In this issue of Immunity, Rangel-Moreno et al...
  29. ncbi Analysis of eosinophil turnover in vivo reveals their active recruitment to and prolonged survival in the peritoneal cavity
    Caspar Ohnmacht
    Institute for Immunology, University of Munich, Munich, Germany
    J Immunol 179:4766-74. 2007
    ..These results demonstrate that the peritoneum serves as reservoir for eosinophils...
  30. ncbi Involvement of KC, MIP-2, and MCP-1 in leukocyte infiltration following injection of necrotic cells into the peritoneal cavity
    Nahoko Tanimoto
    Department of Biomolecular Science, Faculty of Science, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Biochem Biophys Res Commun 361:533-6. 2007
    ..the mechanism, we used an inflammation model induced by injection of necrotic leukemic P388 cells into the peritoneal cavity in this study...
  31. ncbi Live Ascaris lumbricoides in the peritoneal cavity
    Abdullah Refeidi
    Department of Surgery, Aseer Central Hospital, Abha, Saudi Arabia
    Ann Saudi Med 27:118-21. 2007
  32. ncbi Evaluation of different chemical agents on the germinative layer of sheep hydatid cyst after implantation to peritoneal cavity of BALB/c
    Soheil Mansourian
    Department of Surgery, Gastroenterohepatology Research Center, Nemazee Hospital, Shiraz, Iran
    J Invest Surg 22:183-7. 2009
    ..protoscolices lead to recurrence or the recurrence is due to the remainder of the germinative layer in the peritoneal cavity. The aim of this study was in vivo evaluation of different chemical (protoscolicidal) solutions on the ..
  33. ncbi Peritoneal defensins--key contributors to the innate immunity of the peritoneal cavity?
    Randall Faull
    Nephrology, Royal Adelaide Hospital and University of Adelaide, Adelaide, Australia
    Perit Dial Int 27:634-5. 2007
  34. ncbi Gene expression profile of the fibrotic response in the peritoneal cavity
    S J Le
    Centre for Research in Vascular Biology, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane 4072, Australia
    Differentiation 79:232-43. 2010
    The cellular response to materials implanted in the peritoneal cavity has been utilised to produce tissue for grafting to hollow smooth muscle organs (blood vessels, bladder, uterus and vas deferens)...
  35. ncbi Heat penetration in locally applied hyperthermia in the abdomen during intra-operative hyperthermic intraperitoneal chemotherapy
    S van Ruth
    Department of Surgical Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Anticancer Res 23:1501-8. 2003
    ..The aim of this study was to evaluate heat penetration in the abdomen during 10 HIPEC procedures...
  36. ncbi Targeting with oligomannose-coated liposomes promotes maturation and splenic trafficking of dendritic cells in the peritoneal cavity
    Mariko Ishii
    Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Int Immunopharmacol 11:164-71. 2011
    ..Both types of cells rapidly took up OMLs in the peritoneal cavity, but only CD11b(dull)CD11c(+) cells produced interleukin (IL)-12 in response to OML uptake...
  37. pmc Pivotal advance: peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells
    David Parra
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Leukoc Biol 91:525-36. 2012
    ..In a broader context, these newly identified capacities of B-1 B cells further support the previously recognized functional, developmental, and evolutionary relationships between these cells and macrophages...
  38. ncbi Early induced, high-level interleukin-6 expression in the rat peritoneal cavity into which a hepatotoxicant carbon tetrachloride was administered
    Ryoji Zuinen
    Department of Hygienic Chemistry, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    Toxicol Lett 170:42-8. 2007
    ..of CCl4 dissolved in a small amount of vehicle selectively induces a high production of IL-6 in the peritoneal cavity early after the administration...
  39. ncbi Systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal carcinoma
    Tristan D Yan
    Peritoneal Surface Malignancy Program, Washington Cancer Institute, Washington, DC, USA
    J Clin Oncol 24:4011-9. 2006
    ..The efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for patients with peritoneal carcinomatosis from colorectal carcinoma remains to be established...
  40. ncbi Transgastric endoscopic peritoneoscopy does not require decontamination of the stomach in humans
    Vimal K Narula
    Division of General and Gastrointestinal Surgery, The Ohio State University School of Medicine and Public Health, Columbus, OH, USA
    Surg Endosc 23:1331-6. 2009
    ..We report the bacterial load and contamination of the peritoneal cavity in ten patients who underwent diagnostic transgastric endoscopic peritoneoscopy.
  41. pmc Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody
    J W Conlan
    Trudeau Institute, Inc, Saranac Lake, New York 12983
    J Exp Med 179:259-68. 1994
    ..a monoclonal antibody, RB6-8C5, listeriosis is severely exacerbated in the liver, but not in the spleen or peritoneal cavity during the crucial first day of infection...
  42. pmc Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis
    Gareth W Roberts
    Institute of Nephrology, School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, UK
    J Am Soc Nephrol 20:1895-900. 2009
    ..We found that functional effector memory T cells capable of mounting long-term recall responses enrich the peritoneal cavity of PD patients...
  43. ncbi Accelerated senescence of human peritoneal mesothelial cells exposed to high glucose: the role of TGF-beta1
    Krzysztof Ksiazek
    Department of Pathophysiology, University Medical School, Poznan, Poland
    Lab Invest 87:345-56. 2007
    ....
  44. ncbi Peritoneal cavity phagocytes from the teleost sea bass express a glucocorticoid receptor (cloned and sequenced) involved in genomic modulation of the in vitro chemiluminescence response to zymosan
    Aiti Vizzini
    Laboratory of Marine Immunobiology, Dipartimento di Biologia Animale, Universita di Palermo, Via Archirafi, 18, 90123 Palermo, Italy
    Gen Comp Endocrinol 150:114-23. 2007
    ..In situ hybridization assay revealed that DlGR1 was expressed in macrophages and neutrophils from the peritoneal cavity. Since in a previous paper, sea bass PCL chemiluminescence response (CL) has been related to increased ..
  45. ncbi Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat
    Julie Muller
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, 1200 Brussels, Belgium
    Toxicol Sci 110:442-8. 2009
    ..and cancer, these observations prompted us to explore the carcinogenic potential of these MWCNT in the peritoneal cavity of rats...
  46. ncbi Transgastric instrumentation and bacterial contamination of the peritoneal cavity
    Vimal K Narula
    Division of General Surgery, The Ohio State University School of Medicine and Public Health, 410 West 10th Avenue, Ohio, Columbus, 43210 1228, USA
    Surg Endosc 22:605-11. 2008
    ..We report the bacterial load and contamination of the peritoneal cavity in patients requiring a gastrotomy Roux-en-Y gastric bypass (LSRYGB).
  47. ncbi Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase
    K A Lindstedt
    Wihuri Research Institute, FIN 00140 Helsinki, Finland
    FASEB J 15:1377-88. 2001
    ..Selective stimulation of mast cells in vivo in the rat peritoneal cavity leads to rapid overexpression of TGF-beta1 in peritoneal mast cells and of TbetaRs in peritoneal macrophages...
  48. ncbi Endoscopic closure of the natural orifice transluminal endoscopic surgery (NOTES) access site to the peritoneal cavity by means of transmural resorbable sutures: an animal survival study
    D von Renteln
    Department of Gastroenterology, Medizinische Klinik I, Klinikum Ludwigsburg, Ludwigsburg, Germany
    Endoscopy 41:154-9. 2009
    ..To date, no endoscopic technique has utilized resorbable transmural sutures for closure of the NOTES gastrostomy...
  49. ncbi Comparison of Transgastric NOTES and laparoscopic peritoneoscopy for detection of peritoneal metastases
    Rogier P Voermans
    Departments of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Ann Surg 250:255-9. 2009
    ..Transgastric peritoneoscopy (TGP) may be a future alternative to the diagnostic laparoscopy (LAP)...
  50. ncbi Activation of human peritoneal immune cells in early stages of gastric and colon cancer
    Waldemar L Olszewski
    Department for Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    Surgery 141:212-21. 2007
    ..We investigated mobilization of immune cells in peritoneal fluid of gastric and colon cancer, phenotypes and level of activation of recruited cells, and concentration of cellular and peritoneal fluid cytokines...
  51. pmc Effects of nitric oxide on neutrophil influx depends on the tissue: role of leukotriene B4 and adhesion molecules
    A C R M Leite
    Department of Internal Medicine, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil
    Br J Pharmacol 156:818-25. 2009
    ..We investigated the effect of nitric oxide synthase (NOS) inhibition on polymorphonuclear cell (PMN) influx in zymosan or lipopolysaccharide (LPS)-induced arthritis and peritonitis...
  52. pmc Identification of a second neutrophil-chemoattractant cytokine generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to melanoma-growth-stimulatory activity
    P J Jose
    Department of Applied Pharmacology, National Heart and Lung Institute, London, U K
    Biochem J 278:493-7. 1991
    ..The identification of these two cytokines in vivo will provide an opportunity to investigate the importance of their co-release in the inflammatory process...
  53. ncbi Defective B1 cell homing to the peritoneal cavity and preferential recruitment of B1 cells in the target organs in a murine model for systemic lupus erythematosus
    Toshihiro Ito
    Department of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 172:3628-34. 2004
    ..We demonstrate in this study that B1 cells fail to home to the peritoneal cavity in aged BWF1 mice developing lupus nephritis, and that they are preferentially recruited to the target ..
  54. ncbi Histidine decarboxylase expression in mouse mast cell line P815 is induced by mouse peritoneal cavity incubation
    H Ohtsu
    Department of Pharmacology I, Tohoku University School of Medicine, Sendai 980 77, Japan
    J Biol Chem 271:28439-44. 1996
    Phenotype of P815 mouse mast cells changes markedly during culture in the peritoneal cavity of syngenic BDF1 mice...
  55. ncbi Does the use of a uterine manipulator with an intrauterine balloon in total laparoscopic hysterectomy facilitate tumor cell spillage into the peritoneal cavity in patients with endometrial cancer?
    S Lim
    Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang si, Korea
    Int J Gynecol Cancer 18:1145-9. 2008
    ..Possible explanations are retrograde seeding of tumor cells into the peritoneal cavity, the pressure effect of the inflatable manipulator tip, and spillage of preexited tumor cells between the ..
  56. ncbi [A case of intravesical foreign body with a vesical rupture invading the peritoneal cavity: a case report]
    Hiroki Ito
    The Department of Urology, Saiseikai Central Hospital, Tokyo
    Hinyokika Kiyo 55:425-7. 2009
    ..We performed open surgery, and found the urinary bladder to be perforated by a foreign body which invaded the peritoneal cavity. To our knowledge, there were 10 similar cases in Japan.
  57. ncbi The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice
    Yasuhito Hamaguchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 174:4389-99. 2005
    ..By contrast, peritoneal cavity B cells expressed normal CD20 densities and were coated with CD20 mAb, but only 30-43% of B1 cells and 43-78%..
  58. ncbi The peritoneal cavity as a bioreactor for tissue engineering visceral organs: bladder, uterus and vas deferens
    Gordon R Campbell
    Centre for Research in Vascular Biology, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland 4072, Australia
    J Tissue Eng Regen Med 2:50-60. 2008
    ..This study shows that myofibroblast tissue produced in the peritoneal cavity is sufficiently plastic to permit differentiation of cells into bladder, vas deferens or uterine smooth ..
  59. ncbi The natural history of free cancer cells in the peritoneal cavity
    Yutaka Yonemura
    Gastric Surgery Division, Shizuoka Cancer Center, Suntou gun, Nagaizumi machi, Japan
    Recent Results Cancer Res 169:11-23. 2007
  60. ncbi A peritoneal cavity chamber for intravital microscopy of the liver under conditions of pneumoperitoneum
    I Leister
    Department of General Surgery, Georg August University, Robert Kochstrasse 40, D 37075 Gottingen, Germany
    Surg Endosc 17:939-42. 2003
    ..Intravital microscopy allows direct visualization of the hepatic microvasculature. We report on a novel application of this technique using a chamber model that simulates the conditions of pneumoperitoneum...
  61. ncbi A novel safe approach to the peritoneal cavity for per-oral transgastric endoscopic procedures
    Sergey V Kantsevoy
    Division of Gastroenterology, Johns Hopkins Hospital, 1550 Orleans Street, Baltimore, MD 21231, USA
    Gastrointest Endosc 65:497-500. 2007
    ..We have previously reported the feasibility and safety of per-oral transgastric endoscopic procedures in a porcine model...
  62. ncbi Morphological and functional changes in the dialysed peritoneal cavity: impact of more biocompatible solutions
    Olivier Devuyst
    Division of Nephrology, St Luc Academic Hospital, Université Catholique de Louvain Medical School, Brussels, Belgium
    Nephrol Dial Transplant 17:12-5. 2002
    ..The introduction of new more biocompatible solutions potentially allows us to reverse or attenuate these negative changes. This will be discussed in the context of our current understanding of peritoneal pathology in PD...
  63. ncbi The peritoneal micromilieu commits B cells to home to body cavities and the small intestine
    Simon Berberich
    Institute of Immunology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Blood 109:4627-34. 2007
    ..Here we report that exposure of naive B cells to the microenvironment of the peritoneal cavity modulates their migration propensities in the absence of antigenic stimulation...
  64. ncbi Sectional anatomy of the peritoneal reflections of the upper abdomen in the coronal plane
    Zhenmei Zhao
    Department of Anatomy, Shandong University School of Medicine, Jinan 250012, China
    J Comput Assist Tomogr 29:430-7. 2005
    ..The purpose of this study was to provide practical anatomic data for the imaging diagnosis and surgical treatment of the diseases of the subphrenic spaces...
  65. ncbi Haemopoietic origin of myofibroblasts formed in the peritoneal cavity in response to a foreign body
    J H Campbell
    Centre for Research in Vascular Biology, University of Queensland, Brisbane, Australia
    J Vasc Res 37:364-71. 2000
    ..5 mm outer diameter) or boiled blood clot (2-3 mm diameter) placed in their peritoneal cavity. After 3, 5, 7 and 14 days (n = 4/group) the implants were removed and those that had remained free-floating ..
  66. ncbi Patient characteristics associated with defects of the peritoneal cavity boundary
    Claudia M A Van Dijk
    Division of Nephrology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Perit Dial Int 25:367-73. 2005
    Conflicting literature exist regarding the patient characteristics that may confer an increased risk for anatomic complications of the peritoneal cavity boundaries.
  67. ncbi Kinetics and characterization of cellular responses in the peritoneal cavity of mice infected with Taenia crassiceps
    A Padilla
    , , DF,
    J Parasitol 87:591-9. 2001
    Changes in the leukocyte population of the peritoneal cavity ensue immediately after infection with Taenia crassiceps metacestodes...
  68. pmc Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis
    Georg F Weber
    Department of Surgery, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Infect Immun 75:1690-7. 2007
    ..IL-22 therefore appears to play an important role in the regulation of inflammatory processes in vivo...
  69. ncbi Impairment of neutrophil emigration in CD18-null mice
    B Walzog
    Department of Physiology, Freie Universitat Berlin, D 14195 Berlin, Germany
    Am J Physiol 276:G1125-30. 1999
    ..intraperitoneal thioglycollate injection, an in vivo model of inflammation, leukocyte extravasation into the peritoneal cavity was studied in CD18-deficient and wild-type control mice...
  70. ncbi Involvement of MIP-2 and CXCR2 in neutrophil infiltration following injection of late apoptotic cells into the peritoneal cavity
    T Iyoda
    Division of Molecular Medicine, Department of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba 274 8510, Japan
    Apoptosis 9:485-93. 2004
    ..We previously showed that injection of late apoptotic cells into the peritoneal cavity led to transient infiltration of neutrophils...
  71. pmc Intraperitoneal injection of lipopolysaccharide induces dynamic migration of Gr-1high polymorphonuclear neutrophils in the murine abdominal cavity
    Shuichi Miyazaki
    Department of Microbiology, Toho University School of Medicine, Omori nishi 5 21 16, Ota ku, Tokyo 143 8540, Japan
    Clin Diagn Lab Immunol 11:452-7. 2004
    ..or 6-carboxyfluorescein diacethoxylmethyl ester-labeled PMNs injected into the peritoneal cavity were detected in mesenteric lymph nodes 15 min postinjection of LPS...
  72. pmc Effect of anatomical distribution of mast cells on their defense function against bacterial infections: demonstration using partially mast cell-deficient tg/tg mice
    Tomoko Jippo
    Department of Pathology, Medical School Graduate School of Frontier Bioscience, Osaka University, Yamada oka, 2 2, Suita, Osaka 565 0871, Japan
    J Exp Med 197:1417-25. 2003
    Mast cells were depleted in the peritoneal cavity of WBB6F1-tg/tg mice that did not express a transcription factor, MITF...
  73. ncbi CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection
    L Del Rio
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 167:6503-9. 2001
    ..These results highlight an important role for CXCR2 in neutrophil migration, which may be important for early control of infection and induction of immunity during Toxoplasma infection...
  74. ncbi Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha
    Sung Hoon Kim
    Department of Oncology, Graduate School of East West Medical Science, Kyunghee University, 1 Seochunri Kiheungeup, Yoingin 449 701, South Korea
    Int Immunopharmacol 4:279-87. 2004
    ..5 mg/mouse versus PBS treated control 2 h after the i.p. injection of compound 48/80. These results suggest that paeonol has antianaphylatic activity by regulating histamine and TNF-alpha...
  75. ncbi Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis
    C Feterowski
    Department of Surgery, Klinikum rechts der Isar, , , Germany
    Eur J Immunol 31:1268-77. 2001
    ..The results also provide in vivo evidence that apoptosis of inflammatory cells represents an important process for the control of host defense to infection...
  76. ncbi Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines
    Nicolas Kesteman
    Institut de Biologie et Médecine Moléculaires, Universite Libre de Bruxelles, Rue des Prof Jeener et Brachet 12, Gosselies, Belgium
    J Leukoc Biol 83:640-7. 2008
    ..This movement is CD14-dependent, whereas the recruitment of neutrophils in the peritoneal cavity is increased in the absence of CD14...
  77. ncbi Ontogeny, distribution and function of CD38-expressing B lymphocytes in mice
    F R Donís-Hernández
    Department of Molecular Biomedicine, Centro de Investigacion y Estudios Avanzados del I P N, Mexico D F, Mexico
    Eur J Immunol 31:1261-7. 2001
    ..Interestingly, both immature B cells and peritoneal B1 lymphocytes were unresponsive to anti-CD38. However, they were activated by LPS or anti-CD40...
  78. ncbi Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice
    A R Rosenkranz
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 161:6463-7. 1998
    ..mice, which lack this receptor, have significant reductions in the numbers of mast cells resident in the peritoneal cavity, peritoneal wall, and dorsal skin...
  79. ncbi Resident peritoneal leukocytes are important sources of MMP-9 during zymosan peritonitis: superior contribution of macrophages over mast cells
    Elzbieta Kolaczkowska
    Department of Evolutionary Immunobiology, Institute of Zoology, Jagiellonian University, ul Ingardena 6, PL 30 060 Krakow, Poland
    Immunol Lett 113:99-106. 2007
    ..Overall, the study shows that resident tissue leukocytes, mostly macrophages, constitute an important cellular source(s) of inflammation-related factors and should be regarded as possible targets of anti-inflammatory treatment...
  80. ncbi Effect of Bisphenol A on non-specific immunodefenses against non-pathogenic Escherichia coli
    Yoshiko Sugita-Konishi
    Division of Microbiology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Lett 136:217-27. 2003
    ..After the challenge with E. coli, the activity to eliminate bacteria from the peritoneal cavity in the early stage of infection (within 24 h) was diminished compared with non-treated mice...
  81. ncbi Chemical sympathectomy alters numbers of splenic and peritoneal leukocytes
    P A Rice
    Department of Environmental Medicine, University of Rochester School of Medicine, New York 14642, USA
    Brain Behav Immun 16:62-73. 2002
    ..Sympathectomy did not affect tumor necrosis factor-alpha, interleukin-12, or interferon-gamma production in cultured splenocytes or PEC in either infected or uninfected mice...
  82. ncbi Signaling through murine CD38 is impaired in antigen receptor-unresponsive B cells
    F E Lund
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Eur J Immunol 25:1338-45. 1995
    ..Similarly, B-1 cells isolated from the peritoneal cavity of normal mice, and splenic B cells isolated from newborn mice were also unresponsive to both anti-IgM and ..
  83. ncbi Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Immunol 175:2606-12. 2005
    ..In the casein-induced peritonitis model, the appearance of G-CSF in the casein-injected peritoneal cavity associated well with the timing of neutrophil infiltration as well as PGE2 levels in exudates, with a peak ..
  84. ncbi The effects of chemical sympathectomy on T-cell cytokine responses are not mediated by altered peritoneal exudate cell function or an inflammatory response
    Tracy A Callahan
    Graduate Program in Neuroscience, The Center for Psychoneuroimmunology Research, Rochester, New York 14642, USA
    Brain Behav Immun 16:33-45. 2002
    ..These experiments indicate that an inflammatory response is not likely to be responsible for sympathectomy-induced immune alterations, eliminating a potential confounding factor in interpreting sympathectomy studies...
  85. ncbi 129X1/SvJ mouse strain has a novel defect in inflammatory cell recruitment
    Peter White
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:869-74. 2002
    ..Instead, the data revealed a novel and profound defect of cell recruitment in 129X1/SvJ mice, the strain most commonly used for gene deletion studies...
  86. ncbi Effect of lactational exposure to tributyltin chloride on innate immunodefenses in the F1 generation in mice
    Kimiko Kimura
    Department of Veterinary Science, Azabu University, Fuchinobe, Kanagawa, Japan
    Biosci Biotechnol Biochem 69:1104-10. 2005
    ..At weaning time, offspring were inoculated with Escherichia coli K-12, and bacterial clearances from the peritoneal cavity and spleen were examined...
  87. ncbi Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice
    K Takahashi
    Department of Pathology, University of Iowa School of Medicine, Iowa City 52242, USA
    J Immunol 159:1557-69. 1997
    ..We hypothesize that the early decrease in complement receptor expression such as that demonstrated by MRL/lpr mice plays an important role in the pathogenesis of murine and perhaps human SLE...
  88. pmc Transgenic mice showing inflammation-inducible overexpression of granulocyte macrophage colony-stimulating factor
    B Burke
    Division of Infection and Immunity, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Clin Diagn Lab Immunol 11:588-98. 2004
    ..Inducible expression systems such as that described here could be of potential use in the study of the role of cytokines in health and disease and in the development of disease-resistant strains of livestock...
  89. ncbi A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, peritonitis, and cytokine production in vivo
    Liudmila Pietrovna Vlasenko
    Department of Physiology, National University of Singapore, Singapore
    J Immunol 174:6456-61. 2005
    ..The C5a i.p. injection triggered a fast recruitment of neutrophils, later followed by monocytes, into the peritoneal cavity. Vascular permeability was also observed: when we i.v. injected Evans blue before C5a i.p...
  90. pmc Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    Am J Pathol 169:1739-52. 2006
    Controlling metastases remains a critical problem in cancer biology. Within the peritoneal cavity, omental tissue is a common site for metastatic disease arising from intraperitoneal tumors; however, it is unknown why this tissue is so ..
  91. ncbi IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13
    Susan C Fish
    Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 174:7716-24. 2005
    ..These findings suggest that a mechanism for IgE production exists in vivo that is independent of IL-4 or IL-13...
  92. ncbi Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin
    Dagmar García Rivera
    Laboratory of Pharmacology, Department of Biomedical Research, Center of Pharmaceutical Chemistry, P O Box 16042, Havana, Cuba
    J Pharm Pharmacol 58:385-92. 2006
    ..Mangiferin, the major compound of Vimang, contributes to the anti-allergic effects of the extract...
  93. ncbi Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels
    F A Brito
    Departamento de Farmacologia Aplicada, Instituto de Tecnologia em Fármacos, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil
    Braz J Med Biol Res 40:105-15. 2007
    ....
  94. ncbi MTA-induced neutrophil recruitment: a mechanism dependent on IL-1beta, MIP-2, and LTB4
    Alessandra Cristina Gomes
    Department of Basic Sciences, Araçatuba Dentistry School, Sao Paulo State University, Aracatuba, SP, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:450-6. 2008
    ..The objective of this study was to investigate the mediators and the resident peritoneal cells involved in the neutrophil migration (NM) induced by mineral trioxide aggregate (MTA) in mice...
  95. ncbi Morphological alteration of peritoneal mast cells and macrophages in the mouse peritoneal cavity during the early phases of an allergic inflammatory reaction
    S M Oliani
    Department of Biology, IBILCE-UNESP, , SP, Brazil
    Cell Biol Int 25:795-803. 2001
    ..Injection of ovalbumin (100 microg) into the peritoneal cavity of sensitised mice produced a rapid (within 2 h) influx of neutrophils followed by a slower (after >4 h) ..
  96. ncbi Comparative functional characterization of mouse bone marrow-derived mast cells and peritoneal mast cells in response to non-immunological stimuli
    R Singh
    Division of Pharmacology, Central Drug Research Institute, Lucknow, India
    Indian J Exp Biol 39:323-8. 2001
    ..It shows functional heterogeneity within a single species. So, it cannot be assumed that antiallergic compounds stabilizing mast cells in one tissue site or organ will be equally efficacious against mast cells in other sites...
  97. ncbi The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression
    Yuko Kaburagi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 168:2970-8. 2002
    ....
  98. pmc Number of mast cells in the peritoneal cavity of mice: influence of microphthalmia transcription factor through transcription of newly found mast cell adhesion molecule, spermatogenic immunoglobulin superfamily
    Eiichi Morii
    Department of Pathology, Room C2, Osaka University Medical School, Yamada oka 2 2, Suita 565 0871, Japan
    Am J Pathol 165:491-9. 2004
    ..No mast cells were detectable in the stomach, mesentery, and peritoneal cavity of B6-tg/tg mice...
  99. ncbi TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment
    Zane Orinska
    Department of Immunology and Cellular Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Blood 106:978-87. 2005
    ..of poly(I:C) show a decreased CD8+ T-cell recruitment, whereas granulocytes normally migrate to the peritoneal cavity. Mast-cell reconstitution of KitW/KitW-v mice normalizes the CD8+ T-cell influx...
  100. ncbi Mast cells can enhance resistance to snake and honeybee venoms
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Science 313:526-30. 2006
    ..These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms...
  101. ncbi A comparative study of peritoneal mast cells from mutant IL-4 deficient and normal mice: evidence that IL-4 is not essential for mast cell development but enhances secretion via control of IgE binding and passive sensitization
    E M Banks
    Department of Pharmacology and Therapeutics, University of Liverpool, UK
    Cytokine 8:190-6. 1996
    ..In conclusion, IL-4 is not essential for peritoneal mast cell growth and exocytosis but regulates secretion via control of IgE binding and sensitization...

Research Grants64

  1. ROLE OF B.FRAGILIS OXYGEN STRESS RESPONSE IN INFECTION
    Charles J Smith; Fiscal Year: 2013
    ..This is because relative to the colon, the peritoneal cavity is an oxygenated environment, and the recruitment of PMNs to the site of infection will result in exposure ..
  2. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..This disease starts at and is limited to the peritoneal cavity. Currently, National Cancer Institute (NCI) is encouraging a dual mode of therapy for advanced ovarian ..
  3. Characterization of the NOD2 NBD domain and role in chronic inflammation
    Jae W Dugan; Fiscal Year: 2013
    ..Macrophages prepared from bone marrow and peritoneal cavity will be studied for cytokine response, intracellular signalling and autophagosome formation in response to ..
  4. Role of Brain-Specific microRNAs in Suppression of Autoimmune Neuroinflammation
    Howard L Weiner; Fiscal Year: 2013
    ..but not in inflammatory macrophages or normal macrophages isolated from blood, spleen, bone marrow, peritoneal cavity or liver...
  5. Enhancing neutrophil function in neutropenia-related pneumonia
    Hongbo R Luo; Fiscal Year: 2012
    ..The recruitment of neutrophils to the inflamed peritoneal cavity was significantly enhanced in these mice...
  6. B1 B cells in abdominal obesity and diet-accelerated atherosclerosis in SLE
    Xuemei Zhong; Fiscal Year: 2013
    ..B1 B cells reside in the peritoneal cavity and omentum, in direct contact with accumulated and inflamed visceral adipose tissue...
  7. Antiprogestin therapy for ovarian cancer
    CARLOS MARCELO TELLERIA; Fiscal Year: 2012
    ..the confines of the ovaries and into the nearby fallopian tubes, uterus, and various other sites within the peritoneal cavity. As a result, the majority of patients diagnosed with ovarian cancer require surgery followed by platinum-..
  8. RhoH GTPase in Hematopoiesis and Cancer
    David A Williams; Fiscal Year: 2013
    ..of RhoH significantly delays the development of abnormal CD5+IgM+ cells in the bone marrow, spleen and peritoneal cavity. Using gene-targeting approaches, we have previously also demonstrated that Rac1 and Rac2 are required for ..
  9. ROLE OF B.FRAGILIS OXYGEN STRESS RESPONSE IN INFECTION
    Charles Smith; Fiscal Year: 2009
    ..This is because relative to the colon, the peritoneal cavity is an oxygenated environment, and the recruitment of PMNs to the site of infection will result in exposure ..
  10. Integrin Targeted Therapy for the Treatment of Ovarian Cancer
    FRANK CALZONE; Fiscal Year: 2013
    ..Given that ovarian cancer is predominantly confined to the peritoneal cavity, the strategy of localized intraperitoneal (IP) chemotherapy is highly desirable...
  11. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..Our hypothesis is that once HAF is injected in the peritoneal cavity, it distributes and adheres evenly to the walls, improving the adhesiveness between lacerated tissues and ..
  12. Elastogenic Factor Functionalized Electrospun Scaffolds for in vivo Generation of
    CHRISTOPHER A BASHUR; Fiscal Year: 2013
    ..from (a) recruiting a young and potentially more inherently elastogenic source of autologous cells within a peritoneal cavity and (b) utilizing elastogenic factor (HA-o and TGF-21) functionalized electrospun meshes, with sub-micron ..
  13. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel G Remick; Fiscal Year: 2012
    ..Specific aim one will attempt to improve survival by enhancing early recruitment of neutrophils into the peritoneal cavity to help eradicate the focus of infection...
  14. Analysis of the Borrelia burgdorferi Integrin Ligand P66
    Jenifer L Coburn; Fiscal Year: 2013
    ..The p66- mutants do survive in the protected environment of dialysis membrane chambers implanted into the peritoneal cavity, and in the tick after the bloodmeal...
  15. Lymphopoietic development in the extra-embryonic yolk sac
    Mervin C Yoder; Fiscal Year: 2013
    ..yolk sac and the para aortic splanchnopleura (P-Sp) and facilitate the homing of these cells into the peritoneal cavity. Though the extraembryonic yolk sac is the first site of primitive red blood cell, megakaryocyte, and ..
  16. Targeted liposomal radiotherapy of malignant mesothelioma
    Jiang He; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Malignant mesothelioma is a neoplasm of the mesothelial lining of the pleural or peritoneal cavity linked to prior exposure to asbestos...
  17. Aerobic Growth of Anaerobic Pathogens
    ABRAHAM LINCOLN SONENSHEIN; Fiscal Year: 2013
    ..mainly associated with escape from the intestine due to leakage into and formation of abscesses in the peritoneal cavity. C...
  18. Metabolic changes in ovarian cancer cells initiated by metastasis to adipose tiss
    Ernst Lengyel; Fiscal Year: 2013
    ..most epithelial tumors, in that hematogenous metastases are rare, and ovarian tumors remain confined to the peritoneal cavity. The omentum, a large pad of fat tissue (20x13x3cm) covering the bowel, is the most common site of OvCa ..
  19. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn J Randolph; Fiscal Year: 2013
    ..This and other related studies were carried out in the peritoneal cavity, a specialized anatomic compartment that can allow egress of macrophages to the omentum and other adjacent ..
  20. Mechanisms of Monophosporyl Lipid A Immuno-Modulation in Septic Shock
    CHRISTOPHER DAVID MICHAEL ROMERO; Fiscal Year: 2010
    ..Mice will be treated with MPLA prior to bacterial challenge. Specific leukocyte populations in the peritoneal cavity, and bone marrow will be characterized by flow cytometry...
  21. Improving Vaccinia for Peritoneal Tumors: Enhanced Distribution &Immune Evasion
    David L Bartlett; Fiscal Year: 2013
    ..vvDD with the ability to evade the pre-exisiting anti-poxviral immunity and spread widely throughout the peritoneal cavity, by mutating the A34R gene...
  22. The Role of the CXCR4/CXCL12 axis in endometriosis
    ABIGAIL RUIZ-RIVERA; Fiscal Year: 2013
    ..driving this proposal is that overexpression of CXCR4 protein in endometriotic epithelial cells reaching the peritoneal cavity in the menstrual fluid, and its unchartered activation by CXCL12, stimulates proliferation, invasion, and ..
  23. REGULATION OF OVARIAN CARCINOMA PROTEINASES
    MARY SHARON STACK; Fiscal Year: 2013
    ..the EOC metastatic mechanism involves a novel shedding of multi-cellular aggregates (MCAs) into a cavity (peritoneal cavity) as anchorage-independent, chemotherapy-resistant spheroids...
  24. Peptide-targeted alpha-particle emitting phage for ovarian cancer therapy.
    Thomas P Quinn; Fiscal Year: 2013
    ..spread is an important feature in the natural history of the disease;failure to control disease within the peritoneal cavity is a major cause of treatment failure...
  25. MUC1 Roles in ovarian cancer pathogenesis and immune therapy
    Anda M Vlad; Fiscal Year: 2013
    ..because the disease is usually detected late, when the tumors have spread outside of the ovaries, in the peritoneal cavity. Delayed progress in the discovery and implementation of a more effective treatment is partly due to the ..
  26. Signaling in the ovarian cancer metastatic microenvironment
    Jill Slack-Davis; Fiscal Year: 2013
    ..carcinomas metastasize by invading through the mesothelium, a layer of mesothelial cells that line the peritoneal cavity. We reported a novel mechanism for the regulation of mesothelial invasion...
  27. Apoptosis Inducing to Enhance Tumor Targeting
    Ze Lu; Fiscal Year: 2012
    ..These patients usually present with multiple solid tumors in the peritoneal cavity;systemic intravenous (iv) therapy with various chemotherapeutic agents produce an overall response rate of &..
  28. Integrin Linked Kinase and Ovarian Cancer Metastasis
    Lana Y Bruney; Fiscal Year: 2013
    ..of EOC metastasis is unique in that epithelial cells detach from the primary tumor and are shed into the peritoneal cavity as single cells and multicellular aggregates (MCA), that adhere intraperitoneally...
  29. A T-independent pathway of B cell responses to oligomannosyl antigens of HIV-1
    Denong Wang; Fiscal Year: 2013
    ..Similarly, BMan9+ cells represent 10-12% of B-1a (CD19+CD5+) B cells in the mouse peritoneal cavity (PerC)...
  30. The Role of the Microenvironment in Early Ovarian Cancer Metastasis
    HILARY ANN KENNY; Fiscal Year: 2010
    ..One of the most important characteristics of ovarian cancer (OvCa) is metastasis of cancer cells to the peritoneal cavity. The main site of OvCa metastasis is the omentum...
  31. Regulation of the multiple polysaccharides of Bacteroides fragilis
    Laurie E Comstock; Fiscal Year: 2010
    ..If Bacteroides fragilis gains access to the otherwise sterile peritoneal cavity due to a reach in the intestinal barrier from natural, traumatic, or surgical circumstances, it can become ..
  32. Utilizing Ethyl Nitrate Gas in Laparoscopic Surgery
    James Reynolds; Fiscal Year: 2006
    ..However, pneumoperiteneum, the act of insufflating the peritoneal cavity with gas, is not without physiologic consequence: pulmonary function is impaired and organ blood flows ..
  33. OPTIMIZATION OF INTRAPERITONEAL PDT
    Douglas Fraker; Fiscal Year: 2012
    ..responses seen in this heavily pre-treated population but the majority of patients recurred within the peritoneal cavity. This initial Phase II trial using photofrin was limited primarily by low photosensitizer retention in tumor ..
  34. Receptor Cross-Talk in Early Metastatic Dissemination
    MARY SHARON STACK; Fiscal Year: 2013
    ..a unique mechanism involving shedding of non-adherent cells as multi-cellular aggregates (MCAs) into the peritoneal cavity followed by intra-peritoneal (IP) implantation, and is often associated with peritoneal ascites...
  35. Hyaluronan/CD44 and the Early Endometriotic Lesion
    Robert Schenken; Fiscal Year: 2005
    ..proposes that fragments of menstrual endometrium pass retrograde through the fallopian tubes into the peritoneal cavity where they attach and grow on peritoneal surfaces...
  36. SURGERY AND IV NUTRITION MODULATE MACROPHAGE FUNCTION
    W Helton; Fiscal Year: 1999
    ..Mphis will be isolated from the mesenteric lymph nodes, peritoneal cavity, lung, and spleen and their function studied...
  37. Effects of Hyaluronan on Interstitial Convection
    MICHAEL FLESSNER; Fiscal Year: 2007
    ..interstitial transport properties of the barrier between the blood and therapeutic dialysis solutions in the peritoneal cavity. To address the hypothesis, both acute and chronic studies will be carried out in which animals will be ..
  38. Dynamics of Peritoneal Dialysis Associated Peritonitis
    John Hotchkiss; Fiscal Year: 2004
    ..dialysis, the abdominal cavity is intermittently filled with a fluid (PDF) that is allowed to dwell in the peritoneal cavity. During this dwell time, waste products, excess salts, and water diffuse into the PDF...
  39. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    ..proposes that fragments of menstrual endometrium pass retrograde through the fallopian tubes into the peritoneal cavity where they attach and grow on peritoneal surfaces...
  40. BACTEROIDES FRAGILIS CAPSULES--SYNTHESIS AND VIRULENCE
    Arthur Tzianabos; Fiscal Year: 1999
    ..This research will expand our understanding of how bacteria promote abscess formation in the peritoneal cavity and may lead to better therapeutic measures to prevent or treat this disease process.
  41. TAS::75 0849::TAS MAGNETICALLY ENERGIZED NANOPARTICLES FOR TREATING OVARIAN CANC
    STEPHEN BARRY; Fiscal Year: 2010
    ..First, even when metastatic, ovarian cancer is most frequently restricted to the peritoneal cavity. Nanoparticles are readily injected into the tumor-associated-phagocyte-rich ascitic fluid that irrigates ..
  42. IN VIVO STUDY OF INTERSTITIAL CONVECTION
    MICHAEL FLESSNER; Fiscal Year: 1999
    ..Prior research with this animal model has established: that protein acts as a marker of convection from the peritoneal cavity, that the rate of convection is directly proportional to the intraperitoneal (i.p...
  43. Evaluation of In Vivo Optical Imaging in Pancreatic and Ovarian Cancer Patients
    Lainie Martin; Fiscal Year: 2013
    ..Pancreatic and ovarian cancers have a high case-fatality rate due to the early spread of disease to the peritoneal cavity. We are currently unable to detect the spread of micrometastases in patients with apparently localized ..
  44. UTERINE BIOLOGY AND THE PATHOPHYSIOLOGY OF ENDOMETRIOSIS
    Kevin Osteen; Fiscal Year: 2003
    ..cases of endometriosis can be attributed to ectopic implantation of fragments of endometrium entering the peritoneal cavity following reflex menstruation...
  45. Antiprogestins in Cynomolgus Endometriosis
    RONALD WIEHLE; Fiscal Year: 2003
    ..We established methods and the baseline levels of markers of inflammation in the peritoneal cavity of the monkey...
  46. Clinical Testing of an Insulin Analog
    Michael Weiss; Fiscal Year: 2009
    ..of present insulin formulations as stored for 1-3 months within the pump reservoir at 37oC within the peritoneal cavity. Such instability causes aberrant protein aggregation, which frequently impairs insulin delivery due to ..
  47. Commercialization of Human Omental Mesothelial Cells for Research
    YOLANDA LEA CURRIE; Fiscal Year: 2007
    ..cells to allow transfer of waste products from the underlying vasculature to the dialysis fluid in the peritoneal cavity. Host response to peritoneal infection is mediated by the inflammatory cascade initiated and cytokines ..
  48. Commercialization of Human Mesothelial Cells for Research
    YOLANDA RENEE LEA CURRIE; Fiscal Year: 2010
    ..cells to allow transfer of waste products from the underlying vasculature to the dialysis fluid in the peritoneal cavity. Host response to peritoneal infection is mediated by the inflammatory cascade initiated and cytokines ..
  49. Radioimmunotherapy: An Anti-Neoplastic Strategy
    Andres Forero; Fiscal Year: 2006
    ..Thus, in patients with relapsed or primary refractory EOC confined to the peritoneal cavity (+/- retroperitoneal nodes), we will: determine the maximum tolerated dose of IP l31I-HuCC49ACH2 and its ..
  50. OPIOIDS, OPIOID RECEPTORS, AND SEPSIS
    TOBY EISENSTEIN; Fiscal Year: 2001
    ..and induction of inducible nitric oxide synthase (iNOS) in mesenteric lymph nodes, spleen, liver, blood, and peritoneal cavity of morphine or other opioid-treated mice using a quantitative, competitive RT-PCR technique; and 4) examine ..
  51. INTRAPERITONEAL GEMCITABINE--PHASE I & PARMACOKINETICS
    Elizabeth Poplin; Fiscal Year: 1999
    ..of IP chemotherapy is the ability to provide high regional drug concentrations for tumors confined to the peritoneal cavity. The pharmacokinetic advantage' of this regional therapy is primarily dependent on hepatic metabolism ..
  52. Apoptosis Inducing to Enhance Tumor Targeting
    Ze Lu; Fiscal Year: 2004
    ..These patients usually present with multiple solid tumors and malignant ascites in the peritoneal cavity that are not adequately managed by systemic intravenous (iv) therapy...
  53. PLEURAL LIQUID EXCHANGE AND LUNG MECHANICS
    STEPHEN LAI FOOK; Fiscal Year: 2007
    ..and other interstitial membranes and suggested that part of the pleural liquid might be derived from the peritoneal cavity via the diaphragm...
  54. ULTRASTRUCTURAL STUDIES OF CAPILLARY PERMEABILITY
    STEVEN WISSIG; Fiscal Year: 1980
    ..My project has three objectives. The first objective is to examine the pathway of lymphatic drainage of the peritoneal cavity. Peritoneal fluid leaves the cavity chiefly via initial uptake by terminal lymphatic lacunae located on the ..
  55. Phase ii intraperitoneal rhIL 12
    Ralph Freedman; Fiscal Year: 2002
    ..Furthermore, decreased expression of the proangiogenic molecules FGF2 and VEGF on peritoneal cavity tumor was detected at higher dosing levels of IP rhIL- 12...
  56. PATHWAY(S) OF LEUKOCYTE EXTRAVASATION IN INFLAMMATION
    Ann Dvorak; Fiscal Year: 2001
    ..other inflammatory stimuli (proinflammatory cytokines, irritants, antigens, allergens), other tissue sites (peritoneal cavity as well as skin), and other species (rat, mouse, man)? To address this question, several different types of ..
  57. REGULATION OF B CELL CLONAL DIVERSITY
    John Kearney; Fiscal Year: 2000
    ..to the diversity of B-cells that populate the different areas of the spleen and other sites including the peritoneal cavity and gut-associated tissues...
  58. AGING AND OVARIAN CANCER
    KATHERINE ROBY; Fiscal Year: 2000
    ..Multiple tumor implants develop throughout the peritoneal cavity, just as observed in women with ovarian cancer. Ovarian cancer is a disease of aging...
  59. TARGETING AND THERAPY OF TUMORS WITH MONOCLONAL ANTIBODY
    TSANN CHU; Fiscal Year: 1990
    ..Human exfoliated ovarian tumor cells are usually disseminating throughtout the entire peritoneal cavity, and represent an ideal target for therapeutic manipulation in a confined compartment...
  60. TREATMENT OF OVARIAN CANCER WITH CONTORTROSTATIN
    FRANCIS MARKLAND; Fiscal Year: 2001
    ..Since OC disseminates inside the peritoneal cavity, local delivery of CN by intraperitoneal (i.p...
  61. MODIFIED TETRACYCLINE EFFECT ON SEPSIS-INDUCED MORTALITY
    PHILIP FREIDENREICH; Fiscal Year: 2006
    ..results are as follows: 1) we successfully developed an injury consisting of a fecal clot (FC) placed in the peritoneal cavity plus clamping of the superior mesenteric artery (SMA) which resulted in ARDS within 48 hours of the insult, ..
  62. Pathophysiology of Primary Effusion Lymphoma
    JOHN WHELAN; Fiscal Year: 2006
    ..a finding that is amplified and confirmed in a new mouse model we developed for lymphocyte migration to the peritoneal cavity. Furthermore, this phenotype can be imparted to a non-PEL lymphoma cell line by transfecting genes from the ..
  63. TUMOR-SECRETED VASCULAR PERMEABILITY FACTOR
    DONALD SENGER; Fiscal Year: 1993
    ..emphasis on determining the significance of VPF expression for tumor growth and fluid accumulation in the peritoneal cavity. To determine the effects of VPF on tumor growth and fluid accumulation, animals bearing ascites tumors will ..
  64. B7.1 COSTIMULATION IN OVARIAN CANCER
    Ralph Freedman; Fiscal Year: 2001
    ..peritoneal antigen-presenting cells in vivo, and (b) whether the T-cell responses are inhibited in vitro by peritoneal cavity DR+ monocytes that secrete IL-10 and TGF-beta, and whether these effects can be reversed by monoclonal ..