peritoneum

Summary

Summary: A membrane of squamous EPITHELIAL CELLS, the mesothelial cells, covered by apical MICROVILLI that allow rapid absorption of fluid and particles in the PERITONEAL CAVITY. The peritoneum is divided into parietal and visceral components. The parietal peritoneum covers the inside of the ABDOMINAL WALL. The visceral peritoneum covers the intraperitoneal organs. The double-layered peritoneum forms the MESENTERY that suspends these organs from the abdominal wall.

Top Publications

  1. ncbi Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions
    Luiz S Aroeira
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, C Diego de Leon 62, Madrid, Spain
    J Am Soc Nephrol 18:2004-13. 2007
  2. ncbi Mesenchymal conversion of mesothelial cells as a mechanism responsible for high solute transport rate in peritoneal dialysis: role of vascular endothelial growth factor
    Luiz S Aroeira
    Servicio de Nefrologia, Hospital Universitario de la Princesa, Madrid, Spain
    Am J Kidney Dis 46:938-48. 2005
  3. ncbi Morphologic changes in the peritoneal membrane of patients with renal disease
    John D Williams
    Institute of Nephrology, University of Wales College of Medicine, Cardiff, United Kingdom
    J Am Soc Nephrol 13:470-9. 2002
  4. pmc Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage
    Jesus Loureiro
    Unidad de Biología Molecular and Servicio de Nefrología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid, Spain
    J Am Soc Nephrol 22:1682-95. 2011
  5. ncbi Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum
    Peter J Margetts
    Department of Medicine, McMaster University, Division of Nephrology, Street Joseph s Hospital, 50 Charl ton Avenue E, Hamilton, Ontario, Canada, L8P 4A6
    J Am Soc Nephrol 16:425-36. 2005
  6. ncbi The pathophysiology of the peritoneal membrane
    Olivier Devuyst
    Division of Nephrology, UCL Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Am Soc Nephrol 21:1077-85. 2010
  7. ncbi Basic mechanisms and clinical implications of peritoneal fibrosis
    Peter J Margetts
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Perit Dial Int 23:530-41. 2003
  8. pmc Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
    Rachel M McLoughlin
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Clin Invest 112:598-607. 2003
  9. ncbi Angiotensin II mediates high glucose-induced TGF-beta1 and fibronectin upregulation in HPMC through reactive oxygen species
    Hyunjin Noh
    Hyonam Kidney Laboratory, Soon Chun Hyang University, Seoul, Korea
    Perit Dial Int 25:38-47. 2005
  10. ncbi Biology of the peritoneum in normal homeostasis and after surgical trauma
    J B C van der Wal
    Department of Surgery, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Colorectal Dis 9:9-13. 2007

Detail Information

Publications321 found, 100 shown here

  1. ncbi Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions
    Luiz S Aroeira
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, C Diego de Leon 62, Madrid, Spain
    J Am Soc Nephrol 18:2004-13. 2007
    Peritoneal dialysis (PD) is a form of renal replacement and is based on the use of the peritoneum as a semipermeable membrane across which ultrafiltration and diffusion take place...
  2. ncbi Mesenchymal conversion of mesothelial cells as a mechanism responsible for high solute transport rate in peritoneal dialysis: role of vascular endothelial growth factor
    Luiz S Aroeira
    Servicio de Nefrologia, Hospital Universitario de la Princesa, Madrid, Spain
    Am J Kidney Dis 46:938-48. 2005
    During peritoneal dialysis (PD), the peritoneum is exposed to bioincompatible dialysis fluids that cause epithelial-to-mesenchymal transition of mesothelial cells, fibrosis, and angiogenesis...
  3. ncbi Morphologic changes in the peritoneal membrane of patients with renal disease
    John D Williams
    Institute of Nephrology, University of Wales College of Medicine, Cardiff, United Kingdom
    J Am Soc Nephrol 13:470-9. 2002
    ..0001). The density of blood vessels per unit length of peritoneum was significantly higher for patients with membrane failure and was correlated with the degree of fibrosis (P = ..
  4. pmc Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage
    Jesus Loureiro
    Unidad de Biología Molecular and Servicio de Nefrología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid, Spain
    J Am Soc Nephrol 22:1682-95. 2011
    ..Exposure of the peritoneum to PD fluid induced fibrosis, angiogenesis, functional impairment, and the accumulation of fibroblasts...
  5. ncbi Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum
    Peter J Margetts
    Department of Medicine, McMaster University, Division of Nephrology, Street Joseph s Hospital, 50 Charl ton Avenue E, Hamilton, Ontario, Canada, L8P 4A6
    J Am Soc Nephrol 16:425-36. 2005
    ..These findings suggest that EMT occurs in vivo after TGF-beta1 overexpression in the peritoneum. Cellular changes and gene regulation associated with EMT are evident throughout the fibrogenic process and are ..
  6. ncbi The pathophysiology of the peritoneal membrane
    Olivier Devuyst
    Division of Nephrology, UCL Medical School, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Am Soc Nephrol 21:1077-85. 2010
    ..These studies are relevant to mechanisms responsible not only for the major complications of PD but also for endothelial biology, host defense, inflammation, and tissue repair processes...
  7. ncbi Basic mechanisms and clinical implications of peritoneal fibrosis
    Peter J Margetts
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Perit Dial Int 23:530-41. 2003
    ..Changes in the interstitium may have a direct effect on the hydrodynamic properties of the peritoneum and may directly influence fluid movement...
  8. pmc Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
    Rachel M McLoughlin
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    J Clin Invest 112:598-607. 2003
    ..These data emphasize a pivotal role for IFN-gamma in regulating innate immunity through control of both the recruitment and clearance phases of PMN trafficking...
  9. ncbi Angiotensin II mediates high glucose-induced TGF-beta1 and fibronectin upregulation in HPMC through reactive oxygen species
    Hyunjin Noh
    Hyonam Kidney Laboratory, Soon Chun Hyang University, Seoul, Korea
    Perit Dial Int 25:38-47. 2005
    To demonstrate the presence of an independent renin-angiotensin system (RAS) in the peritoneum and to determine the role of locally produced angiotensin (Ang) II in high glucose-induced upregulation of transforming growth factor (TGF)-..
  10. ncbi Biology of the peritoneum in normal homeostasis and after surgical trauma
    J B C van der Wal
    Department of Surgery, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Colorectal Dis 9:9-13. 2007
    The peritoneum is a serous membrane, which has a protective function for the contents of the abdominal cavity...
  11. ncbi Peritoneal mesothelial cell culture and biology
    Susan Yung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Perit Dial Int 26:162-73. 2006
    ..dynamic membrane that contributes substantially to the structural, functional, and homeostatic properties of the peritoneum. Since peritoneal mesothelial cells in culture possess immunohistochemical markers identical to mesothelial stem ..
  12. ncbi Fewer adhesions induced by laparoscopic surgery?
    C N Gutt
    Department of General, Visceral and Trauma Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Surg Endosc 18:898-906. 2004
    ..Laparoscopic surgery has potential theoretical advantages over open surgery in reducing the rate of adhesion formation, but very few comparative studies are available to prove this...
  13. ncbi Histologic criteria for diagnosing encapsulating peritoneal sclerosis in continuous ambulatory peritoneal dialysis patients
    Kazuho Honda
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Adv Perit Dial 19:169-75. 2003
    ..manifestation (n = 5), cases of infectious peritonitis (n = 20), cases of ultrafiltration failure (n = 25), and peritoneum at the start of peritoneal dialysis (n = 7)...
  14. ncbi Transforming growth factor {beta}1 induces epithelial-mesenchymal transition by activating the JNK-Smad3 pathway in rat peritoneal mesothelial cells
    Qinghua Liu
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Perit Dial Int 28:S88-95. 2008
    ..In the present study, we investigated the role of JNK-Smad pathway in EMT induced by TGFbeta1 in RPMCs...
  15. ncbi Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
    S M Hurst
    Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, United Kingdom
    Immunity 14:705-14. 2001
    ....
  16. ncbi Encapsulating peritoneal sclerosis--a clinician's approach to diagnosis and medical treatment
    Hidetomo Nakamoto
    Department of Nephrology, Tokorozawa Kidney Clinic, Tokorozawa, Japan
    Perit Dial Int 25:S30-8. 2005
    ..The diagnosis is confirmed by laparoscopy or laparotomy showing the characteristic gross thickening of the peritoneum enclosing some or all of the small intestine in a cocoon of opaque tissue...
  17. ncbi Myofibroblastic conversion of mesothelial cells
    An Hang Yang
    Department of Pathology, Taipei Veterans General Hospital and School of Medicine, National Yang Ming University, Taipei, Taiwan
    Kidney Int 63:1530-9. 2003
    ..Although several studies have implicated TGF-beta in peritoneal fibrosis, the underlying mechanism has not been completely elucidated...
  18. ncbi Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5
    Yuta Saito
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, Japan
    Clin Exp Metastasis 27:197-205. 2010
    We previously reported that the adhesion of gastric carcinoma cells to the peritoneum mediated by the alpha3beta1 integrin-laminin interaction is a key step in the initial process of peritoneal metastatic dissemination...
  19. ncbi Oxidative stress-dependent increase in ICAM-1 expression promotes adhesion of colorectal and pancreatic cancers to the senescent peritoneal mesothelium
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland
    Int J Cancer 127:293-303. 2010
    ..These results indicate that increased oxidative stress and increased expression of ICAM-1 in senescent HOMCs may facilitate peritoneal adhesion of selected colorectal and pancreatic cancers...
  20. ncbi Peritoneal mast cells in peritoneal dialysis patients, particularly in encapsulating peritoneal sclerosis patients
    Dominik M Alscher
    Department of Internal Medicine, Division of General Internal Medicine and Nephrology, Robert Bosch Hospital, Stuttgart, Germany
    Am J Kidney Dis 49:452-61. 2007
    We assumed that increased mast cell numbers contribute substantially to the fibrosis often seen in the peritoneum of peritoneal dialysis (PD) patients, particularly those with encapsulating peritoneal fibrosis (EPS)...
  21. ncbi In search of the best peritoneal adhesion model: comparison of different techniques in a rat model
    Susan H Whang
    Department of General Surgery, University of Missouri School of Medicine, Columbia, Missouri, USA
    J Surg Res 167:245-50. 2011
    ..The aim of this study was to compare quality and quantity of adhesions in four different models and to find the best model...
  22. ncbi Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis
    Hideki Yokoi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Kidney Int 81:160-9. 2012
    ..To study this, we used microarray analysis and compared gene expression profiles of the peritoneum in control and chlorhexidine gluconate (CG)-induced peritoneal fibrosis mice...
  23. ncbi Ex vivo analysis of dialysis effluent-derived mesothelial cells as an approach to unveiling the mechanism of peritoneal membrane failure
    Manuel López-Cabrera
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, Diego de Leon, 62, 28006 Madrid, Spain
    Perit Dial Int 26:26-34. 2006
    During peritoneal dialysis (PD), the peritoneum is exposed to bioincompatible dialysis fluids, which causes progressive fibrosis and angiogenesis and, ultimately, ultrafiltration failure...
  24. pmc Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
    Peter J Margetts
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 160:2285-94. 2002
    Peritonitis, a common complication of peritoneal dialysis, is followed by acute changes in the function of the peritoneum. The role of inflammatory cytokines in these processes is not clearly identified...
  25. ncbi Peritoneal response to pneumoperitoneum and laparoscopic surgery
    M Bergstrom
    Department of Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, S 41685 Göteborg, Sweden
    Br J Surg 89:1465-9. 2002
    It is generally believed that laparoscopic surgery inflicts less trauma to the peritoneum than open surgery. Local peritoneal fibrinolysis is a critical factor in adhesion development...
  26. ncbi Vascular endothelial growth factor production and regulation in human peritoneal mesothelial cells
    Sonja Mandl-Weber
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik Innenstadt, Klinikum der Universitat Munchen, Munich, Germany
    Kidney Int 61:570-8. 2002
    ..The present study was designed to assess the influence of proinflammatory cytokines, thrombin, d-glucose and glycated albumin in the regulation of VEGF synthesis in primary HMC cultures...
  27. ncbi The effects of renin-angiotensin system inhibition on regression of encapsulating peritoneal sclerosis
    Devrim Bozkurt
    Department of Nephrology, Ege University, Izmir, Turkey
    Perit Dial Int 28:S38-42. 2008
    ..a clinical syndrome associated with symptoms of ileus and irreversible sclerosis of both visceral and parietal peritoneum. Peritoneal dialysis (PD) patients rarely develop EPS, a severe life-threatening condition of unknown ..
  28. ncbi The impact of gas laparoscopy on abdominal plasminogen activator activity
    M Nagelschmidt
    Second Department of Surgery, Biochemical and Experimental Division, University of Cologne, Ostmerheimer Strasse 200, 51109 Cologne, Germany
    Surg Endosc 15:585-8. 2001
    ..05) and the ileum (-70.8%) of the CO2 group but only slightly aggravated in the helium group. The parietal peritoneum was not specifically affected by gas insufflation...
  29. ncbi Modulation of the expression of vascular endothelial growth factor in human fibroblasts
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Detroit, MI 48201, USA
    Fertil Steril 83:405-9. 2005
    ..To examine the up-regulation of vascular endothelial growth factor (VEGF) expression by hypoxia, a crucial event leading to neovascularization, as the reduction in VEGF expression may facilitate minimization of adhesion development...
  30. ncbi Peritoneal changes after exposure to sterile solutions by catheter
    Michael F Flessner
    Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    J Am Soc Nephrol 18:2294-302. 2007
    ..These findings confirm the hypothesis that the presence of a PC catheter increases inflammatory response to sterile solutions as evidenced by the structural and functional changes in the peritoneal barrier...
  31. ncbi Emodin ameliorates glucose-induced matrix synthesis in human peritoneal mesothelial cells
    Tak Mao Chan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Kidney Int 64:519-33. 2003
    ..How emodin modulates glucose-induced abnormalities in HPMC has not been elucidated and thus constitutes the theme of this study...
  32. ncbi Peritoneal mesothelial cells produce inflammatory related cytokines
    Veronica Yao
    School of Surgery and Pathology, The University of Western Australia, Perth, Western Australia, Australia
    ANZ J Surg 74:997-1002. 2004
    ..The present study evaluates the interplay between various putative inducers of peritonitis and a battery of inflammation-related cytokines...
  33. ncbi Peritoneal mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation in a laparoscopic mouse model
    C R Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Belgium
    Fertil Steril 76:560-7. 2001
    ..To develop a laparoscopic mouse model to evaluate the hypothesis that mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation...
  34. ncbi Mesothelial cells
    Susan Yung
    Department of Medicine, University of Hong Kong, Hong Kong SAR, PR China
    Perit Dial Int 27:S110-5. 2007
    ....
  35. ncbi Abdominal adhesion prevention: still a sticky subject?
    Chris I W Lauder
    University of Adelaide Discipline of Surgery, The Queen Elizabeth Hospital, Woodville, SA, Australia
    Dig Surg 27:347-58. 2010
    ..There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk...
  36. ncbi Pathology of encapsulating peritoneal sclerosis
    Kazuho Honda
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Perit Dial Int 25:S19-29. 2005
    ..This encapsulation is frequently accompanied by fibrin deposition, focal bleeding on the peritoneum, and various quantities of bloody ascites...
  37. ncbi Smad3-dependent and -independent pathways are involved in peritoneal membrane injury
    Pranali Patel
    Department of Medicine, McMaster University, Hamilton, Canada
    Kidney Int 77:319-28. 2010
    ..cells to a mesenchymal phenotype plays an integral role in the angiogenic and fibrotic changes seen in the peritoneum of patients receiving long-term peritoneal dialysis...
  38. ncbi Computed tomographic findings characteristic for encapsulating peritoneal sclerosis: a case-control study
    Anniek Vlijm
    Department of Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Perit Dial Int 29:517-22. 2009
    ..To establish CT findings characteristic for EPS, we compared CT findings between EPS patients and long-term peritoneal dialysis (PD) patients without EPS...
  39. ncbi Peritoneal glucose exposure and changes in membrane solute transport with time on peritoneal dialysis
    S J Davies
    Department of Nephrology, North Staffordshire Hospitals Trust, Stoke on Trent, United Kingdom
    J Am Soc Nephrol 12:1046-51. 2001
    ..Continuous exposure of the peritoneum to hypertonic glucose solutions results in morphologic damage that may have a causative role in changes in ..
  40. pmc Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
    Mai Lan N Huynh
    Department of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 109:41-50. 2002
    ..In conclusion, apoptotic cell recognition and clearance, via exposure of PS and ligation of its receptor, induce TGF-beta1 secretion, resulting in accelerated resolution of inflammation...
  41. ncbi Consequences and complications of peritoneal adhesions
    H van Goor
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Colorectal Dis 9:25-34. 2007
    ..Filmy adhesions between movable organs and the peritoneum appear to be worse in terms of generating pain...
  42. pmc Cyclooxygenase-2 mediates dialysate-induced alterations of the peritoneal membrane
    Luiz S Aroeira
    Instituto Reina Sofía de Investigaciones Nefrológicas, Hospital Universitario La Paz, Madrid, Spain
    J Am Soc Nephrol 20:582-92. 2009
    ..In conclusion, upregulation of COX-2 during EMT may mediate peritoneal inflammation, suggesting COX-2 inhibition as a potential strategy to ameliorate peritoneal deterioration in PD patients...
  43. ncbi Single-center experience of encapsulating peritoneal sclerosis in patients on peritoneal dialysis for end-stage renal failure
    Angela M Summers
    Department of Renal Medicine, Manchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, UK
    Kidney Int 68:2381-8. 2005
    ..The aim of this study was to evaluate the clinical features of EPS and identify possible risk factors for its development in CAPD and APD patients...
  44. ncbi Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model
    Shunsuke Takahashi
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi Minami ku, Hiroshima, Japan
    Nephron Exp Nephrol 112:e59-69. 2009
    ..We therefore examined the effects of mizoribine in an experimental model of peritoneal fibrosis...
  45. pmc Assessing the validity of an abdominal CT scoring system in the diagnosis of encapsulating peritoneal sclerosis
    Ruth M Tarzi
    Imperial College Kidney and Transplant Institute, Hammersmith Hospital, London, UK
    Clin J Am Soc Nephrol 3:1702-10. 2008
    ..The early clinical features may be nonspecific. The purpose of the study is to assess the reliability and diagnostic utility of abdominal CT scanning in the diagnosis of EPS...
  46. ncbi Serosal involvement in gastrointestinal cancer: its assessment and significance
    L Ludeman
    Department of Histopathology, Gloucestershire Royal Hospital, Gloucester, UK
    Histopathology 47:123-31. 2005
    ..Furthermore, there is increasing interest in alternative novel strategies, including intraperitoneal chemotherapy and radical peritoneal surgery, as legitimate therapeutic options in many gastrointestinal cancers...
  47. ncbi Mesothelial RAGE activation by AGEs enhances VEGF release and potentiates capillary tube formation
    E Boulanger
    Vascular and Cellular Biology Laboratory, Institut National de la Transfusion Sanguine, University of Paris7 Denis Diderot, Paris, France
    Kidney Int 71:126-33. 2007
    ..05 and P<0.001, respectively. In a co-culture system, we showed that VEGF production by HPMC favors capillary tube formation through mesothelial RAGE activation and could explain neoangiogenesis in PD patient...
  48. ncbi A new approach to postoperative peritoneal adhesions: prevention of peritoneal trauma by aloe vera gel
    Erhan Aysan
    Istanbul Educational and Research Hospital, Turkey
    Eur J Obstet Gynecol Reprod Biol 149:195-8. 2010
    ..Covering peritoneal surfaces with aloe vera gel may prevent peritoneal trauma and hence postoperative peritoneal adhesions...
  49. ncbi Visualizing the network of Bonghan ducts in the omentum and peritoneum by using Trypan blue
    Byung Cheon Lee
    Research Institute of Basic Sciences, Seoul National University, Seoul, Korea
    J Acupunct Meridian Stud 2:66-70. 2009
    ..By using it, we observed a weblike network of BHDs which was in various membrane structures, such as the peritoneum, and omenta...
  50. ncbi Sphingosine kinase 1 gene transfer reduces postoperative peritoneal adhesion in an experimental model
    Q Guo
    Department of General Surgery, General Hospital of People s Liberation Army, Beijing Institute of Radiation Medicine, Beijing, China
    Br J Surg 95:252-8. 2008
    ..This study determined the effect of SPK-1 gene transfer on the recovery of damaged mesothelial cells and on peritoneal adhesion formation after surgery...
  51. pmc Gene manipulated peritoneal cell patch repairs infarcted myocardium
    Wei Huang
    Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    J Mol Cell Cardiol 48:702-12. 2010
    A gene manipulated cell patch using a homologous peritoneum substrate was developed and applied after myocardial infarction to repair scarred myocardium...
  52. ncbi Smad7 transgene attenuates peritoneal fibrosis in uremic rats treated with peritoneal dialysis
    Hong Guo
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    J Am Soc Nephrol 18:2689-703. 2007
    ..25% dextrose-containing fluid. The peritoneum of uremic rats treated with PD demonstrated fibrosis, increased TGF-beta expression, increased Smad2/3 ..
  53. ncbi The pathogenesis and therapeutic option of encapsulating peritoneal sclerosis
    H Kawanishi
    Tsuchiya General Hospital, 3 30 Nakajima cho, Naka ku, Hiroshima 730 8655, Japan
    Int J Artif Organs 28:150-5. 2005
    ..If the state of bowel obstruction persists, laparotomy and enterolysis should be performed to obtain complete cure. It is now recognized that EPS is not a fatal complication of PD...
  54. ncbi Needlescopic totally extraperitoneal hernioplasty for unilateral inguinal hernia in adult patients
    Wong Hoi She
    Division of Colorectal Surgery, Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR
    Asian J Surg 34:23-7. 2011
    ..We report our prospective study that compared the postoperative outcomes of these two approaches over a 2-year period...
  55. ncbi Alternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis
    Teresa Bellón
    Research Unit, Hospital Universitario La Paz FIBHULP, Madrid, Spain
    Nephrol Dial Transplant 26:2995-3005. 2011
    ....
  56. ncbi A new approach for decreasing postoperative peritoneal adhesions: preventing peritoneal trauma with soybean oil
    Erhan Aysan
    Istanbul Teaching Hospital, Istanbul, Turkey
    J Invest Surg 22:275-80. 2009
    ..Covering peritoneal surfaces with soybean oil may decrease peritoneal adhesions by preventing peritoneal trauma...
  57. ncbi Smad7 gene transfer inhibits peritoneal fibrosis
    J Nie
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Kidney Int 72:1336-44. 2007
    ..Our studies suggest that ultrasound-mediated Smad7 gene delivery may be useful in the prevention or treatment of dialysis-induced peritoneal fibrosis...
  58. ncbi Peritoneal fast transport in incident peritoneal dialysis patients is not consistently associated with systemic inflammation
    Anabela S Rodrigues
    Nephrology Department, Hospital Geral Santo Antonio, Porto, Portugal
    Nephrol Dial Transplant 21:763-9. 2006
    ..Our objective was to investigate if fast transport status in incident patients is associated with markers of inflammation and atherosclerosis, and its relationship to patient survival...
  59. ncbi Epidemiology of encapsulating peritoneal sclerosis in Japan
    Hideki Kawanishi
    Akane Foundation, Tsuchiya General Hospital, Hiroshima, Japan
    Perit Dial Int 25:S14-8. 2005
    ..Maintaining patients on standard PD for more than 8 years using conventional solutions is associated with a substantial risk for the development of EPS...
  60. ncbi Prevention of postoperative peritoneal adhesions
    Remah M Kamel
    European University Diploma of Operative Endoscopy, France
    Eur J Obstet Gynecol Reprod Biol 150:111-8. 2010
    ..By the end of the study, recommendations formulated for surgeons to be followed during the operations to prevent, as much as possible, the postoperative adhesions...
  61. ncbi Effects of peritoneal dialysis solutions on the secretion of growth factors and extracellular matrix proteins by human peritoneal mesothelial cells
    Hunjoo Ha
    Hyonam Kidney Laboratory, Soon Chun Hyang University, Seoul, Korea
    Perit Dial Int 22:171-7. 2002
    ....
  62. ncbi Biocompatibility and tolerability of a purely bicarbonate-buffered peritoneal dialysis solution
    Lars Weiss
    Department Division of Nephrology, Centralsjukhuset, Karlstad, Germany
    Perit Dial Int 29:647-55. 2009
    ..Many studies have shown the biocompatibility of neutral lactate-buffered solutions; however, until now, the effect of purely bicarbonate-buffered solutions has not been intensively studied in vivo...
  63. ncbi The role of the TGF/Smad signaling pathway in peritoneal fibrosis induced by peritoneal dialysis solutions
    Qiang Yao
    Divisions of Baxter Novum and Renal Medicine, Department of Clinical Science, Karolinska Institutet, Stockholm, Sweden
    Nephron Exp Nephrol 109:e71-8. 2008
    ....
  64. ncbi Difference in the expression of hormone receptors and fibrotic markers in the human peritoneum--implications for therapeutic targets to prevent encapsulating peritoneal sclerosis
    Niko Braun
    Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital, Stuttgart, Germany
    Perit Dial Int 31:291-300. 2011
    ..of nuclear receptors [progesterone (PR), androgen (AR), vitamin D (VDR), and glucocorticoid (GCR)] in the human peritoneum. We also investigated estrogen receptor (ER), matrix metalloproteinase 9 (MMP9), and transforming growth factor ..
  65. ncbi Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrier
    L April Gago
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 80:612-6. 2003
    ..To characterize the molecular changes that occur in normal fibroblasts, adhesion fibroblasts, and mesothelial cells as a result of exposure to modified hyaluronic acid and carboxymethylcellulose (Seprafilm)...
  66. pmc Senescent peritoneal mesothelial cells promote ovarian cancer cell adhesion: the role of oxidative stress-induced fibronectin
    Krzysztof Ksiazek
    Department of Pathophysiology, Poznan University of Medical Sciences, Swiecickiego 6, 60 781 Poznan, Poland
    Am J Pathol 174:1230-40. 2009
    ..These data indicate that oxidative stress that accompanies senescence may increase FN production by HOMCs and thus facilitate binding and dissemination of ovarian cancer cells...
  67. ncbi Adenoviral-mediated gene expression of hepatocyte growth factor prevents postoperative peritoneal adhesion in a rat model
    Hong Jun Liu
    Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, People s Republic of China
    Surgery 140:441-7. 2006
    ..Hepatocyte growth factor (HGF) is a multifunctional cytokine that stimulates proliferation and migration of various cell types, including mesothelial cells...
  68. ncbi Prolonged exposure to glucose degradation products impairs viability and function of human peritoneal mesothelial cells
    J Witowski
    Department of Nephrology and Medical Intensive Care, , Campus Virchow-Klinikum, , Berlin, Germany
    J Am Soc Nephrol 12:2434-41. 2001
    ....
  69. pmc Astragalus extract inhibits destruction of gastric cancer cells to mesothelial cells by anti-apoptosis
    Di Na
    Department of Oncology, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
    World J Gastroenterol 15:570-7. 2009
    ..To determine the inhibitory effect of Astragalus memebranaceushas on gastric cancer cell supernatant-induced apoptosis of human peritoneal mesothelial cells...
  70. ncbi Encapsulating peritoneal sclerosis in Japan: a prospective, controlled, multicenter study
    Hideki Kawanishi
    Tsuchiya General Hospital, Hiroshima, Japan
    Am J Kidney Dis 44:729-37. 2004
    ..Encapsulating peritoneal sclerosis (EPS) is recognized as a rare but serious complication of peritoneal dialysis (PD). The aim of this study was to determine the incidence, clinical features, and mortality rate of EPS...
  71. ncbi Recent concepts in the molecular biology of the peritoneal membrane - implications for more biocompatible dialysis solutions
    Siska Mortier
    Renal Division, University Hospital, De Pintelaan, Ghent, Belgium
    Blood Purif 21:14-23. 2003
    ..functional alterations of the membrane following repeated peritonitis is the consequence of the response of the peritoneum to infective organisms involving the inflammatory cytokines and the interaction between membrane resident cell ..
  72. ncbi Heat-killed microorganisms induce PAI-1 expression in human peritoneal mesothelial cells: role of interleukin-1alpha
    S Mandl-Weber
    Medizinische Klinik, , Munich, Germany
    Am J Kidney Dis 37:815-9. 2001
    ..Because the increase in PAI-1 expression is significantly quenched by blocking the activity of IL-1alpha, the mesothelial release of this cytokine is involved in bacterial-induced changes in the fibrinolytic system...
  73. ncbi Intestinal obstruction due to idiopathic sclerosing encapsulating peritonitis. Clinical report and review of literature
    V Minutolo
    Dipartimento Scienze Chirurgiche, Trapianti d Organo, Universita degli Studi di Catania
    G Chir 29:173-6. 2008
    ..In this report we describe surgical treatment, pathologic pattern and clinical findings of this rare disease...
  74. ncbi Pentoxifylline modulates intracellular signalling of TGF-beta in cultured human peritoneal mesothelial cells: implications for prevention of encapsulating peritoneal sclerosis
    Kuan Yu Hung
    Department of Internal Medicine, Far Eastern Memorial Hospital, Pan Chiao, Taiwan, ROC
    Nephrol Dial Transplant 18:670-6. 2003
    ..In this study, we explored these signalling pathways in HPMC, and investigated the molecular mechanisms involved in the inhibitory effects of PTX on TGF-beta-induced collagen gene expression in HPMC...
  75. ncbi Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4
    Sawako Kato
    Division of Clinical Immunology, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Soc Nephrol 15:1289-99. 2004
    ..The results provide a candidate molecular target in prevention of it...
  76. ncbi Reduction of perlecan synthesis and induction of TGF-beta1 in human peritoneal mesothelial cells due to high dialysate glucose concentration: implication in peritoneal dialysis
    Susan Yung
    Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    J Am Soc Nephrol 15:1178-88. 2004
    ..Since perlecan can sequester growth factors, thereby modulating cell migration and differentiation perturbation of peritoneal perlecan expression contributes to the structural and functional changes of the peritoneum in long-term PD.
  77. ncbi Genetic polymorphism of VEGF: Impact on longitudinal change of peritoneal transport and survival of peritoneal dialysis patients
    Cheuk Chun Szeto
    Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Kidney Int 65:1947-55. 2004
    ..We hypothesis that VEGF genetic polymorphism may affect the longitudinal change of peritoneal transport and clinical outcome of peritoneal dialysis patients...
  78. ncbi Peritoneal proteoglycans: much more than ground substance
    Susan Yung
    Department of Medicine, University of Hong Kong, Hong Kong
    Perit Dial Int 27:375-90. 2007
    ....
  79. ncbi Peritoneal fibrosis intervention
    Kayo Kaneko
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Perit Dial Int 27:S82-6. 2007
    ..biocompatible dialysate, targeting mediators responsible for inflammation and fibrosis, and reconstituting the peritoneum using mesothelial or bone marrow-derived cells...
  80. ncbi Vascular endothelial growth factor in peritoneal dialysis: a longitudinal follow-up
    M M Zweers
    Department of Nephrology, Academic Medical Center Amsterdam, and the Dianet Foundation Utrecht-Amsterdam, The Netherlands
    J Lab Clin Med 137:125-32. 2001
    ..we calculated the power relationship between D/S ratios of serum proteins that are only transported across the peritoneum and the molecular weights of those proteins. The measured VEGF D/S ratio was higher than expected (P <...
  81. ncbi Biocompatible peritoneal dialysis solutions: do we have one?
    Kunal Chaudhary
    Division of Nephrology and Hypertension, University of Missouri Columbia School of Medicine, Harry S Truman VA Medical Center, 800 Hospital Drive, Columbia, MO 65201, USA
    Clin J Am Soc Nephrol 5:723-32. 2010
    ..This review discusses the current status of these biocompatible solutions in PD patients...
  82. ncbi Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 79:164-8. 2003
    ..To determine whether normal peritoneal and adhesion fibroblasts express tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-I) and whether their expression is regulated by oxygen...
  83. ncbi Hyaluronan fragments induce the synthesis of MCP-1 and IL-8 in cultured human peritoneal mesothelial cells
    B Haslinger
    Medizinische Klinik Innenstadt, , Munich, Germany
    Cell Tissue Res 305:79-86. 2001
    ..In concert with previous findings, our observations indicate that enhanced levels of HA, which are present in the peritoneal cavity of peritoneal dialysis patients, may account for a locally increased chemokine production...
  84. ncbi Apparent successful mesothelial cell transplantation hampered by peritoneal activation
    Liesbeth H P Hekking
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Kidney Int 68:2362-7. 2005
    ..Mesothelial cell transplantation has been suggested to improve mesothelial repair after surgery, recurrent peritonitis and peritoneal dialysis...
  85. ncbi The C5a chemoattractant receptor mediates mucosal defence to infection
    U E Höpken
    Ina Sue Perlmutter Cystic Fibrosis Laboratory, Children s Hospital, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 383:86-9. 1996
    ..We conclude that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung...
  86. ncbi Antiangiogenic and antifibrotic gene therapy in a chronic infusion model of peritoneal dialysis in rats
    Peter J Margetts
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine and Division of Nephrology, McMaster University, Hamilton, Canada
    J Am Soc Nephrol 13:721-8. 2002
    ..Net ultrafiltration was used as a measure of membrane function, and peritoneum-associated vasculature and mesenteric collagen content was quantified...
  87. ncbi Angiotensin II induces fibronectin expression in human peritoneal mesothelial cells via ERK1/2 and p38 MAPK
    Kei Kiribayashi
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Kidney Int 67:1126-35. 2005
    ..However, there is scant data regarding the effect of angiotensin II (Ang II) on ECM expression and signal transduction pathways in HPMC...
  88. ncbi Vascular endothelial growth factor is essential for hyperglycemia-induced structural and functional alterations of the peritoneal membrane
    A S De Vriese
    Renal Unit, Ghent University, De Pintelaan 185, B 9000 Ghent, Belgium
    J Am Soc Nephrol 12:1734-41. 2001
    ..an increased vascular density with focal areas of irregular capillary budding was found in the diabetic peritoneum. The hyperglycemia-induced structural and functional microvascular alterations were prevented by long-term ..
  89. ncbi Molecular characterization of postoperative adhesions: the adhesion phenotype
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    J Am Assoc Gynecol Laparosc 11:307-14. 2004
    ..Improved understanding of these events and their regulation will provide the opportunity to regulate better postoperative adhesion development and tissue fibrosis, thereby reducing the morbidity and mortality they cause...
  90. ncbi Long-term exposure to new peritoneal dialysis solutions: Effects on the peritoneal membrane
    Siska Mortier
    Renal Unit, University Hospital, Ghent, Belgium
    Kidney Int 66:1257-65. 2004
    Chronic exposure to peritoneal dialysis fluid (PDF) affects the peritoneum, but precise causative factors are incompletely understood. We examined the effects of standard and new PDF on peritoneal function and structure.
  91. ncbi Peritoneal rest may successfully recover ultrafiltration in patients who develop peritoneal hyperpermeability with time on continuous ambulatory peritoneal dialysis
    Anabela Rodrigues
    Nephrology Department, Hospital Geral Santo Antonio, Porto, Portugal
    Adv Perit Dial 18:78-80. 2002
    ..If a pause is initiated soon after diagnosis of UF failure, results may improve further. We urge prospective studies to better determine the best and timely therapeutic approach in patients with loss of ultrafiltration...
  92. ncbi Impact of laparoscopic gases on peritoneal microenvironment and essential parameters of cell function
    P Wildbrett
    Department of Surgery, Humboldt University Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Surg Endosc 17:78-82. 2003
    ....
  93. ncbi Effect of laparoscopic and conventional colorectal resection on peritoneal fibrinolytic capacity: a prospective randomized clinical trial
    J Neudecker
    Department of General, Visceral, Vascular, and Thoracic Surgery, Medical Faculty, Humboldt University, Charite Campus Mitte, Schumannstrasse 20 21, 10117 Berlin, Germany
    Int J Colorectal Dis 17:426-9. 2002
    Reduced fibrinolytic activity of the peritoneum seems to be the main cause of postoperative adhesions...
  94. ncbi Impact of temperature and humidity of carbon dioxide pneumoperitoneum on body temperature and peritoneal morphology
    Eric J Hazebroek
    Department of Surgery, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Laparoendosc Adv Surg Tech A 12:355-64. 2002
    ..study were to investigate whether heating or humidification of insufflation gas could prevent peroperative hypothermia in a rat model, and to assess whether the peritoneum was affected by heating or humidification of the insufflation gas.
  95. ncbi Postoperative intraperitoneal adhesion pathophysiology
    J J Duron
    Chirurgie générale et digestive, Hopital de la Pitie Salpetriere, 83 Boulevard de l hopital, Paris, France
    Colorectal Dis 9:14-24. 2007
    ....
  96. ncbi Morphologic changes of peritoneum and expression of VEGF in encapsulated peritoneal sclerosis rat models
    Hiroaki Io
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Kidney Int 65:1927-36. 2004
    ..The objective of the present study is to evaluate serial morphologic changes and expressions of angiogenic factors [i.e., vascular endothelial growth factor (VEGF), angiopietin-1 (Ang-1), and angiopoietin-2 (Ang-2)] in EPS rat models...
  97. ncbi Endostatin peptide, an inhibitor of angiogenesis, prevents the progression of peritoneal sclerosis in a mouse experimental model
    K Tanabe
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Kidney Int 71:227-38. 2007
    ..These results demonstrate the potential use of antiangiogenic endostatin peptide as a novel therapeutic agent in preventing peritoneal sclerosis, a severe complication in patients undergoing long-term PD...
  98. ncbi Cancer stem cell-like SP cells have a high adhesion ability to the peritoneum in gastric carcinoma
    Takafumi Nishii
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Cancer Sci 100:1397-402. 2009
    ..Oct3/4 and Sox2 may be associated with CSC in gastric cancer...
  99. ncbi Evidence for incorporation of free-floating mesothelial cells as a mechanism of serosal healing
    Adam J Foley-Comer
    Department of Medicine, Royal Free and University College Medical School, The Rayne Institute, London, WC1E 6JJ, UK
    J Cell Sci 115:1383-9. 2002
    ..This study has clearly shown that serosal healing involves implantation, proliferation and incorporation of free-floating mesothelial cells into the regenerating mesothelium...
  100. pmc An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria 3084, Australia
    J Exp Med 188:1611-9. 1998
    ..NK cell recruitment into the peritoneum was abrogated in TNF-deficient mice challenged with RMA-S or RM-1, a B6 MHC class I- prostate carcinoma, ..
  101. ncbi Longitudinal relationship between solute transport and ultrafiltration capacity in peritoneal dialysis patients
    Simon J Davies
    Department of Nephrology, University Hospital of North Staffordshire, Stoke on Trent, Staffordshire, United Kingdom
    Kidney Int 66:2437-45. 2004
    ..The purpose of this analysis was to establish how solute transport and UF capacity change relative to one another with time on therapy...

Research Grants62

  1. The Role of The Histone Epigenome in the Pathophysiology of Endometriosis
    MARICARMEN COLON; Fiscal Year: 2012
    ..various theories attempt to explain the mechanisms whereby endometrial cells are able to survive and grow in the peritoneum and other ectopic sites, forming lesions that are hormone-dependent1...
  2. Commercialization of Tissue Lined Stent Graft for Dialysis Access Failure
    DON GUSTAVSON; Fiscal Year: 2013
    ..Additionally, native arterial venous fistulas also a high failure rate PeriTec Biosciences has developed a novel peritoneum lined stent (PLS)...
  3. Novel Biological Tissue Lined Vascular Stent Crimping and Delivery System
    MICHAEL JOHN WIGGINS; Fiscal Year: 2010
    ..Peritec Biosciences has developed a novel peritoneum lined stent (PLS) and unique delivery system...
  4. CCR2 in Hematopoietic Stem Cell Homing, Macrophage Polarization and Organ Repair
    Israel F Charo; Fiscal Year: 2013
    ..Following instillation of thioglycollate WT, but not CCR2-/- stem cells were actively recruited to the peritoneum, and to the liver following administration of acetaminophen...
  5. Targeted liposomal radiotherapy of malignant mesothelioma
    Jiang He; Fiscal Year: 2011
    ..Since mesothelioma is generally a regional disease within the pleura and peritoneum, aggressive surgery can resect most of solid viable tumor...
  6. The Role of LOX and LOXL1 in the Pathophysiology of Endometriosis
    PERLA MARIA BAEZ; Fiscal Year: 2010
    ..This knowledge is important to understand how endometrial cells are able to survive, grow in the peritoneum and metastasize to other organs, causing a painful, poorly understood disease known as endometriosis.
  7. Role of the Fractalkine Signaling in EOC
    Maria V Barbolina; Fiscal Year: 2012
    ..literature our hypothesis is that CX3CL1/CX3CR1 axis is required for homing metastatic EOC cells to the peritoneum and facilitation of metastatic spread by supporting cell adhesion and migration...
  8. A macaque model for endometriosis induced pelvic pain and infertility
    Ov D Slayden; Fiscal Year: 2013
    ..Enthusiasm for Aim 1 emanates from pilot studies where we inoculated the peritoneum with menstrual endometrium in artificially-cycled monkeys...
  9. Device for Surgical Adhesion Prevention
    REKHA BANSAL; Fiscal Year: 2010
    ..After surgery, fibrous adhesions form in the peritoneum, central nervous system, pericardium, pleura and synovium...
  10. Implantable Microdevice for the Treatment of Hydrocephalus
    HONGSEOK NOH; Fiscal Year: 2009
    ..of implanting a shunt device that diverts the CSF from the brain into another part of the body such as the peritoneum. The shunt device consists of a one-way valve and two long tubes connected to the ventricular space and the ..
  11. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2012
    ..receptor plays a primary role in the uptake and clearance of apoptotic cells and cell debris which seed the peritoneum as a result of retrograde menstruation...
  12. Regulation of Adhesion and Proteolysis in Ovarian Cancer
    Ernst Lengyel; Fiscal Year: 2013
    ..The first cells which metastatic OvCa cells encounter are the mesothelial cells which line the peritoneum and omentum of the abdominal cavity...
  13. Adaptation of an Organotypic 3 Dimensional Culture for High-Throughput Screening
    Ernst Lengyel; Fiscal Year: 2011
    ..The peritoneum and the omentum, which is a large pad of fat tissue covering the bowel, are the most common sites of metastasis...
  14. The Role of Eicosanoids in Shock
    James A Cook; Fiscal Year: 2013
    ..The enhanced mobilization of neutrophils correlated with greatly accelerated bacterial clearance in peritoneum, blood and lung and survival...
  15. Epilysin in Lung Immunity
    ANNE M MANICONE; Fiscal Year: 2010
    ..is a key effector of macrophage influx, by assessing several models of injury/inflammation in the lung and peritoneum. Our second aim will determine the cellular source of epilysin that regulates macrophage recruitment into the ..
  16. Role of Toll-like receptors in Coxiella burnetii infection
    Mark A Jutila; Fiscal Year: 2013
    ..Though a few studies of C. burnetii infection of the peritoneum in TLR deficient animals have been published, to date there have been no reports using TLR deficient animals and ..
  17. SRP RNA level as a determinant of leishmanial parasitism of macrophages
    Gautam Chaudhuri; Fiscal Year: 2009
    ..3) Evaluation of the effects of Leishmania exposure of macrophages isolated from the peritoneum of the transplanted mice on the levels of phagolysosomal proteins, surface membrane receptors and the levels of ..
  18. The Role of the Microenvironment in Early Ovarian Cancer Metastasis
    HILARY ANN KENNY; Fiscal Year: 2010
    ..patients with OvCa present in an advanced stage that involves the dissemination of cancer cells throughout the peritoneum cavity...
  19. NF-kB and Chromatin Changes in Human Sepsis
    CHARLES EMORY MCCALL; Fiscal Year: 2013
    ..phase shifts, using biochemical and genetic methods to analyze plasma and isolated leukocytes from spleen, peritoneum, and bone marrow;and b) use pharmacologic and genetic approaches to determine whether modifying to adaptive ..
  20. Utilizing Ethyl Nitrate Gas in Laparoscopic Surgery
    James Reynolds; Fiscal Year: 2006
    ..As the released nitric oxide can act locally (i.e. within the peritoneum) as well as entering the systemic circulation and, in the case of the gravid patient, the fetal circulation (..
  21. ENVIRONMENTAL ASBESTOS AND MESOTHELIOMA IN CALIFORNIA
    Marc Schenker; Fiscal Year: 2001
    ..deposits in California are associated with increased rates of mesothelioma, a rare cancer of the pleura and peritoneum that occurs almost solely as a result of asbestos exposure...
  22. Hyaluronan/CD44 and the Early Endometriotic Lesion
    Robert Schenken; Fiscal Year: 2005
    ..We recently developed a novel in vitro model of endometriosis using explants of human peritoneum or mesothelial cell monolayers and mechanically dispersed endometrial cells...
  23. Stent Lock Mechanism for Transcutaneous Catheters
    NICHOLAS VITALE; Fiscal Year: 2005
    ..However, should infection occur along the catheter or within the peritoneum, surgery is required to remove and replace the catheter...
  24. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    ..2) evaluate the effect of CSF-1 stimulation on endometrial attachment, invasion and growth in the peritoneum, and evaluate the mechanisms involved in CSF-1/c-fms mediated actions that may contribute to endometriosis, (3) ..
  25. LEUKOCYTE ADHESION IN ALLERGIC INFLAMMATION
    P Sriramarao; Fiscal Year: 2009
    ..of key molecules involved in the sequestration of eosinophils to different vascular beds such as the peritoneum and the pulmonary vascular bed...
  26. Oncolytic Vesicular Stomatitis Virus for the Treatment of Colorectal Cancer
    John H Stewart; Fiscal Year: 2012
    ..delivery of oncolytic VSV can effectively treat properly selected, metastatic colorectal tumors of the liver and peritoneum. This hypothesis will be tested by three specific aims...
  27. Laser-Activated Collagen Adhesives for Herniorrhaphy
    Barbara Soltz; Fiscal Year: 2006
    ..of solder and mesh configurations, tissue bonding strategies, comparison of acute tensile strength of bonded peritoneum and the assessment of mesh stability, tissue damage and the presence/type of adhesions in a six week chronic ..
  28. NEW BCAS FOR RADIOIMMUNOTHERAPY WITH RADIOMETALS
    Donald Buchsbaum; Fiscal Year: 2001
    ..it would be valuable to determine in preclinical studies whether 188Re-HuCC49ACH2 administered in the peritoneum produces a higher relative tumor uptake in Jp...
  29. Peritumorally transformable nanoparticles for intraperitoneal chemotherapy of ova
    Yoon Yeo; Fiscal Year: 2010
    ..by difficulties in IP chemotherapy due to several reasons including short residence time of drugs in the peritoneum, potential of pan-peritoneal toxicity, and insufficient intracellular uptake/accumulation of the anti-cancer ..
  30. PERITONEAL MACROPHAGE MIGRATION IN ENDOMETRIOSIS
    CECIL LYTTLE; Fiscal Year: 1993
    ..the identification of the mechanism responsible for the directed migration or chemotaxis of macrophages to the peritoneum. Preliminary data have demonstrated a significant increase in the concentration and activity of a macrophage ..
  31. IN VIVO DETECTION OF FREE RADICALS USING NMR
    Thomas Clanton; Fiscal Year: 2000
    ..In these experiments we will test the ability of 31P-NMR to detect localized inflammation in the peritoneum and ischemia-reperfusion in the isolated heart...
  32. GLYCOSIDE ANTAGONISTS OF GLYCOSYLATION
    Jeffrey Esko; Fiscal Year: 2000
    ..compounds also will be tested in a mouse inflammatory model that measures infiltration of leukocytes into the peritoneum in response to irritation...
  33. Photodynamic Therapy of Disseminated Peritoneal Tumor Using New Photosensitizers
    J Wharton; Fiscal Year: 2009
    ..cancer as a result of shedding cells followed by implantation into other tissues and organs within the peritoneum. It occurs in late stages of cancer but is also responsible for tumor recurrence in patients with resectable ..
  34. LYMPHOCYTE/TUMOR INTERACTIONS IN SCID/HU CHIMERIC MICE
    Albert Donnenberg; Fiscal Year: 1993
    ..Because this tumor is primarily confined to the peritoneum, it is particularly well suited for xenografting studies; both human tumors and human lymphocyte/monocyte ..
  35. COMPLEMENT C3 AND ACQUIRED AND INNATE IMMUNITY
    Michael Carroll; Fiscal Year: 2003
    ..3) examine the importance of local synthesis of C3 in host defense against bacterial infection in the peritoneum. Understanding the regulation of the repertoire of natural antibody is important both for clarification of basic ..
  36. Collectin-induced phagocytosis of apoptotic cells
    Peter Henson; Fiscal Year: 2004
    ..Finally, the role of collectins and calreticulin in removal of apoptotic cells and cell debris will be examined in the inflamed peritoneum and lung using inhibitors and knockout mice.
  37. DEVELOPMENT AND REGULATION OF TESTICULAR MACROPHAGES
    JAMES HUTSON; Fiscal Year: 1992
    ..or inducing the testis- specific phenotype, we will treat macrophages from the testis, blood (monocytes), peritoneum, lung and ovary with factors form testicular extracts, interstitial fluid or culture medium of various ..
  38. ICTALURUS PUNCTATUS--A MODEL TO STUDY MUCOSAL IMMUNITY
    JOANNE MAKI; Fiscal Year: 2002
    ..multifiliis exposure (i.e., skin, gill and peritoneum); 2) to identify and localize I...
  39. PAPILLARY SEROUS CARCINOMA OF THE PERITONEUM
    Samuel Mok; Fiscal Year: 2000
    Papillary serous carcinoma of the peritoneum (PSCP) is a malignancy, occuring exclusively in women, which is histologically indistinguishable from papillary serous carcinoma of the ovary...
  40. Solid State Beta Imaging Sensor for Radioguided Surgery
    Gerald Entine; Fiscal Year: 2007
    ..and treatment of solid tumor cancers, including those of the head and neck, female reproductive system, skin, peritoneum, mesentery, lung, bronchus, colon and rectum...
  41. NOVEL MONOCYTE AND T CELL TRAFFICKING RECEPTOR
    Eugene Butcher; Fiscal Year: 1999
    ..cells to inflamed or cytokine-activated EC; and on monocyte recruitment to the experimentally inflamed peritoneum in vivo...
  42. EVALUATION OF CH2 DELETED HUCC49 FOR INTRAPERITONEAL RIT
    Donald Buchsbaum; Fiscal Year: 2001
    ..would be valuable to determine in preclinical studies whether 131|- or 177LU-HuCC49deltaCh2 administered in the peritoneum combined with administration of interferon (IFN)to upregulate TAG-72 antigen produces a higher relative tumor ..
  43. Understanding chemokine synergism in type 1 diabetes
    MARY PAUZA; Fiscal Year: 2004
    ..will be addressed by exploring chemokine-mediated functions at two distinct sites: subcutaneous interstitium and peritoneum. A complementary model system using osmotic infusion pumps will be developed to test the in vivo effects of ..
  44. ENDOCAM/PECAM--A NOVEL VASCULAR CELL ADHESION MOLECULE
    Steven Albelda; Fiscal Year: 1999
    ..of peptides with defined in vitro functions to block leukocyte transmigration into thioglycollate stimulated peritoneum in an in vivo model of murine inflammation, and by determination of in vitro and in vivo expression status of ..
  45. TARGETING ENDOGENOUS ANTIBODIES TO OVARIAN CARCINOMA
    Moo Cho; Fiscal Year: 2003
    ..Finally these GAL-/FR+cells will be introduced into peritoneum of healthy GT/KO mice...
  46. MONONUCLEAR CELL FACTORS AFFECTING BASOPHIL/MAST CELLS
    J Grant; Fiscal Year: 1992
    ..Monoclonal antibodies will be raised in mice using purified HRF. Hybridoma cells will be grown in the peritoneum of pristane-treated mice. Purified antibody will be used to develop ELISA and/or RIA as well as affinity columns...
  47. A rodent model to study toxicology and human viruses
    Ann Cornell Bell; Fiscal Year: 2003
    ..George and Catherine Wu of University of CT Health Center. Injection of human hepatocytes into the peritoneum of embryonic rats results in a new born "tolerized" rat that does not mount an immune reaction to later ..
  48. B CELLS AND ACQUIRED T CELL IMMUNITY
    Philip Askenase; Fiscal Year: 1999
    ..1+ cells, and activated B-1 cells may possibly migrate from peritoneum to lymph nodes, and potentially have diverse V regions, and higher Ag affinity. SPECIFIC AIM #3...
  49. Lysophospholipid Mediators in Ovarian Cancer
    Andrew Morris; Fiscal Year: 2005
    ..Ovarian cancer cells synthesize LPA and release this mediator into ascites fluid which accumulates in the peritoneum and bathes abdominal tumors...
  50. ROLE OF CYTOKINES IN SEPSIS AND TRAUMA
    Daniel Remick; Fiscal Year: 2004
    ..will attempt to improve outcome by increasing the local neutrophil recruitment to the site of inflammation, the peritoneum. While neutrophils may cause organ injury, they are also a critical component of the innate immune response for ..
  51. Functions of Transmembrane and Soluble Fas ligand
    Ann Marshak Rothstein; Fiscal Year: 2005
    ..5-10 times more effectively than wtFasL cells; mFasL cells induce greater neutrophil extravasation into the peritoneum than wtFasL cells; and mFasL lymphoma cells injected into syngeneic mice via the "immunoprivileged" anterior ..
  52. A Vh gene that blocks development of follicular B cells
    Timothy Manser; Fiscal Year: 2006
    ..8 amino acid substitutions, B2 cells are essentially absent, B1 cells are present at near normal levels in the peritoneum, and most B cells in the spleen are of the MZ phenotype...
  53. Central and Peripheral Sugars and the Opioid System
    Rinah Yamamoto; Fiscal Year: 2004
    ..Bypassing the gustatory response, by administering the sugar into the peritoneum or directly into brain sites could help to resolve this issue...
  54. PERITONEAL DELIVERY OF ANTINEOPLASTIC MACROMOLECULES
    MICHAEL FLESSNER; Fiscal Year: 2004
    ..Applicant's Abstract) Macromolecular agents are increasingly being used to treat residual disease on the peritoneum arising from intra-abdominal carcinomas...
  55. Effects of Hyaluronan on Interstitial Convection
    MICHAEL FLESSNER; Fiscal Year: 2007
    ..mathematical model to create a quantitative tool capable of predicting transport of water and solute across the peritoneum with a range of tissue HA levels...
  56. FETAL-MATERNAL IMMUNOLOGICAL INTERACTIONS
    Leonore Herzenberg; Fiscal Year: 1991
    ..The other lineage (Ly-1 B), which derives from self-renewing progenitors in adult peritoneum, is strikingly different from conventional B cells, e.g...
  57. RESTRICTION OF HSV REPLICATION IN MACROPHAGES
    ELISE SARMIENTO BATTERSON; Fiscal Year: 1990
    ..Macrophages (from bone marrow, spleen, liver, peritoneum and lung) from susceptible and resistant inbred strains of mice, AND human peripheral blood monocytes will be ..
  58. ASSAY FOR DETERMINING DRUG TOXICITY
    Chuenlei Parng; Fiscal Year: 2001
    ..culture assays using either rat or mouse embryos, and in utero assays in which compounds are injected in the peritoneum of a pregnant mouse or rat...
  59. Wayne State University Clinical Translational Science
    Michael Diamond; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  60. TIMING OF MAMMALIAN CELL CYCLE EVENTS
    ROBERT KLEVECZ; Fiscal Year: 1991
    ..Tumor cell proliferation maxima and kinetic indices will be compared with those taken from the bone marrow and the labeling and release of tumor cells from the solid tumor into the peritoneum will be measured.
  61. Improving Ovarian Cancer Treatment by Targeting a Novel Epitope of MUC16
    Rachel Kravitz; Fiscal Year: 2009
    ..These antibodies will be extremely useful materials for creation of therapeutic agents that can efficiently target and cytolyze ovarian tumors in the peritoneum.