vibrissae

Summary

Summary: Stiff hairs projecting from the face around the nose of most mammals, acting as touch receptors.

Top Publications

  1. ncbi The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex
    Sandrine Lefort
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015, Switzerland
    Neuron 61:301-16. 2009
  2. ncbi Multiple dynamic representations in the motor cortex during sensorimotor learning
    D Huber
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA
    Nature 484:473-8. 2012
  3. ncbi Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
  4. ncbi In vivo, low-resistance, whole-cell recordings from neurons in the anaesthetized and awake mammalian brain
    Troy W Margrie
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, Heidelberg 69120, Germany
    Pflugers Arch 444:491-8. 2002
  5. pmc Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch
    Marcel Oberlaender
    Digital Neuroanatomy, Max Planck Florida Institute, Jupiter, FL 33458 2906, USA
    Proc Natl Acad Sci U S A 108:4188-93. 2011
  6. ncbi A novel single-cell staining procedure performed in vivo under electrophysiological control: morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or Neurobiotin
    D Pinault
    Université Laval Centre de Recherche en Neurobiologie Hôpital de l Enfant Jésus, Quebec, Canada
    J Neurosci Methods 65:113-36. 1996
  7. ncbi Sparse temporal coding of elementary tactile features during active whisker sensation
    Shantanu P Jadhav
    Computational Neurobiology Graduate Program, University of California, San Diego, La Jolla, California, USA
    Nat Neurosci 12:792-800. 2009
  8. ncbi Sniffing and whisking in rodents
    Martin Deschenes
    Department of Psychiatry and Neuroscience, Laval University, Quebec City G1J 2G3, Canada
    Curr Opin Neurobiol 22:243-50. 2012
  9. ncbi Correlated input reveals coexisting coding schemes in a sensory cortex
    Luc Estebanez
    Unité de Neurosciences, Information et Complexité, UPR 3293, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Nat Neurosci 15:1691-9. 2012
  10. ncbi Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice
    Isabelle Ferezou
    Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
    Neuron 56:907-23. 2007

Detail Information

Publications288 found, 100 shown here

  1. ncbi The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex
    Sandrine Lefort
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015, Switzerland
    Neuron 61:301-16. 2009
    ..Our data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution...
  2. ncbi Multiple dynamic representations in the motor cortex during sensorimotor learning
    D Huber
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA
    Nature 484:473-8. 2012
    ..The activity of a subpopulation of neurons was consistent with touch driving licking behaviour. Our results suggest that ensembles of motor cortex neurons couple sensory input to multiple, related motor programs during learning...
  3. ncbi Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
    ..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity...
  4. ncbi In vivo, low-resistance, whole-cell recordings from neurons in the anaesthetized and awake mammalian brain
    Troy W Margrie
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, Heidelberg 69120, Germany
    Pflugers Arch 444:491-8. 2002
    ..AP firing in the brain might therefore be far sparser than previously thought...
  5. pmc Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch
    Marcel Oberlaender
    Digital Neuroanatomy, Max Planck Florida Institute, Jupiter, FL 33458 2906, USA
    Proc Natl Acad Sci U S A 108:4188-93. 2011
    ..During tactile-driven behavior, such as object location, near-coincident input from these two pathways may result in increased spiking activity of thick-tufted neurons and thus enhanced signaling to their subcortical targets...
  6. ncbi A novel single-cell staining procedure performed in vivo under electrophysiological control: morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or Neurobiotin
    D Pinault
    Université Laval Centre de Recherche en Neurobiologie Hôpital de l Enfant Jésus, Quebec, Canada
    J Neurosci Methods 65:113-36. 1996
    ....
  7. ncbi Sparse temporal coding of elementary tactile features during active whisker sensation
    Shantanu P Jadhav
    Computational Neurobiology Graduate Program, University of California, San Diego, La Jolla, California, USA
    Nat Neurosci 12:792-800. 2009
    ..Slips are thus a fundamental encoded tactile feature in natural whisker input streams and are represented by sparse, temporally precise, synchronous spiking in S1...
  8. ncbi Sniffing and whisking in rodents
    Martin Deschenes
    Department of Psychiatry and Neuroscience, Laval University, Quebec City G1J 2G3, Canada
    Curr Opin Neurobiol 22:243-50. 2012
    ..Here, we review the similarities between sniffing and whisking and suggest that such similarities indicate a mechanistic link between these two rhythmic exploratory behaviors...
  9. ncbi Correlated input reveals coexisting coding schemes in a sensory cortex
    Luc Estebanez
    Unité de Neurosciences, Information et Complexité, UPR 3293, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Nat Neurosci 15:1691-9. 2012
    ..We suggest that similar context-dependent coexisting coding strategies may be present in other sensory systems to adapt sensory integration to specific stimulus statistics...
  10. ncbi Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice
    Isabelle Ferezou
    Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
    Neuron 56:907-23. 2007
    ..Sensory processing in motor cortex may therefore contribute significantly to active tactile sensory perception...
  11. ncbi Short-term depression at thalamocortical synapses contributes to rapid adaptation of cortical sensory responses in vivo
    Sooyoung Chung
    Department of Biology and, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 34:437-46. 2002
    ..These data strongly suggest that synaptic depression of thalamic input to the cortex contributes to the dynamic regulation of neuronal sensitivity during rapid changes in sensory input...
  12. ncbi Map plasticity in somatosensory cortex
    Daniel E Feldman
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, Room 0357, La Jolla, CA 92093, USA
    Science 310:810-5. 2005
    ..This view contrasts with the classical model in which the map plasticity reflects a single Hebbian process acting at a small set of cortical synapses...
  13. pmc Primary motor cortex reports efferent control of vibrissa motion on multiple timescales
    DANIEL N HILL
    Computational Neuroscience Graduate Program, University of California, San Diego, San Diego, CA 92093, USA
    Neuron 72:344-56. 2011
    ....
  14. pmc Shifts in coding properties and maintenance of information transmission during adaptation in barrel cortex
    Miguel Maravall
    Instituto de Neurociencias de Alicante UMH CSIC, Campus de San Juan, Sant Joan d Alacant, Spain
    PLoS Biol 5:e19. 2007
    ..Our results suggest that adaptation enhances tactile representations in primary somatosensory cortex, where they could directly influence perceptual decisions...
  15. ncbi Somatosensory cortical neuronal population activity across states of anaesthesia
    Irina A Erchova
    Cognitive Neuroscience Sector, International School for Advanced Studies, Via Beirut, 9, 34014 Trieste, Italy
    Eur J Neurosci 15:744-52. 2002
    ..The possible significance of the cyclic cortical responsiveness encountered during urethane anaesthesia to cortical processing in awake rats is considered...
  16. pmc Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column
    Dirk Feldmeyer
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Jahnstrasse 29, D 69120 Heidelberg, Germany
    J Physiol 538:803-22. 2002
    ....
  17. pmc Cell type-specific thalamic innervation in a column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2287-303. 2010
    ....
  18. pmc Effects and mechanisms of wakefulness on local cortical networks
    Christine M Constantinople
    Department of Neuroscience and the Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA
    Neuron 69:1061-8. 2011
    ..Indeed, blockade of noradrenergic, but not cholinergic, pathways induced synaptic quiescence during wakefulness. We conclude that global brain states can switch local recurrent networks into different regimes via direct neuromodulation...
  19. ncbi Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice
    Graham W Knott
    Institut de Biologie Cellulaire et Morphologie, Universite de Lausanne, Rue du Bugnon 9, CH 1005, Lausanne, Switzerland
    Neuron 34:265-73. 2002
    ..These results indicate activity-dependent alterations in synaptic circuitry in adulthood, modifying the flow of sensory information into the cerebral cortex...
  20. pmc Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2277-86. 2010
    ..The number of APs evoked in a column by a sensory stimulus (principal whisker deflection) was estimated as 4441 within 100 ms post-stimulus...
  21. ncbi Vibrissa-based object localization in head-fixed mice
    Daniel H O'Connor
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    J Neurosci 30:1947-67. 2010
    ..Mice actively used their mystacial vibrissae (whiskers) to sense the location of a vertical pole presented to one side of the head and reported with licking ..
  22. pmc Dynamic representation of whisker deflection by synaptic potentials in spiny stellate and pyramidal cells in the barrels and septa of layer 4 rat somatosensory cortex
    Michael Brecht
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    J Physiol 543:49-70. 2002
    ..This presumably reflects the divergence of thalamocortical projections to different barrels. Septum cell PSPs preferably represent multiple whisker deflections, but less dynamically and with less spatial acuity...
  23. ncbi The functional organization of the barrel cortex
    Carl C H Petersen
    Laboratory of Sensory Processing, Brain Mind Institute, SV BMI LSENS, Station 15, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Neuron 56:339-55. 2007
    ..The prominence of state-dependent cortical sensory processing is likely to be crucial in our understanding of active sensory perception, experience-dependent plasticity and learning...
  24. ncbi Unsupervised whisker tracking in unrestrained behaving animals
    Jakob Voigts
    Undergraduate Program in Mathematics, University of Heidelberg, Heidelberg, Germany
    J Neurophysiol 100:504-15. 2008
    ..e., speed, amplitude and duration) of whisker touch and finally show that whisker deprivation does not alter whisking kinematics during haptic exploration...
  25. ncbi Vibrissa movement elicited by rhythmic electrical microstimulation to motor cortex in the aroused rat mimics exploratory whisking
    Rune W Berg
    Department of Physics, University of California at San Diego, La Jolla, California 92093, USA
    J Neurophysiol 90:2950-63. 2003
    The rhythmic motor activity of the vibrissae that rodents use for the tactile localization of objects provides a model system for understanding patterned motor activity in mammals...
  26. pmc Anticipatory activity of motor cortex in relation to rhythmic whisking
    Wendy A Friedman
    Department of Psychology, Hunter College, City University of New York, New York, New York, USA
    J Neurophysiol 95:1274-7. 2006
    ..These data support the hypothesis that vMCx may initiate and modulate whisking behavior through its action on a subcortical CPG...
  27. ncbi Response properties of whisker-associated trigeminothalamic neurons in rat nucleus principalis
    Brandon S Minnery
    Department of Neurobiology, University of Pittsburgh, Pennsylvania 15261, USA
    J Neurophysiol 89:40-56. 2003
    ....
  28. pmc Superior sensation: superior colliculus participation in rat vibrissa system
    Marie E Hemelt
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Neurosci 8:12. 2007
    ..In anesthetized rats, we characterized extracellularly recorded responses of collicular neurons to different types of vibrissa stimuli...
  29. ncbi Whisker movements evoked by stimulation of single pyramidal cells in rat motor cortex
    Michael Brecht
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Nature 427:704-10. 2004
    ..We conclude that in vibrissae motor cortex sparse AP activity can evoke movements.
  30. ncbi Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
    Elizabeth J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 134:4335-45. 2007
    ..cell populations in the posterior forelimb, caudal pharyngeal arches, secondary heart field and sensory vibrissae and maintains key signalling centres at these diverse tissues sites...
  31. pmc Neuronal activity in rat barrel cortex underlying texture discrimination
    Moritz von Heimendahl
    Cognitive Neuroscience Sector, International School for Advanced Studies, Trieste, Italy
    PLoS Biol 5:e305. 2007
    ..In conclusion, these data suggest that barrel cortex firing rate on each trial leads directly to the animal's judgment of texture...
  32. pmc Encoding of whisker input by cerebellar Purkinje cells
    Laurens W J Bosman
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    J Physiol 588:3757-83. 2010
    ....
  33. ncbi Effect of subthreshold up and down states on the whisker-evoked response in somatosensory cortex
    Robert N S Sachdev
    Department of Biology, University of Texas, San Antonio 78249 0662, USA
    J Neurophysiol 92:3511-21. 2004
    ..Different mechanisms are therefore responsible for the state-dependence of PSP amplitude and the spike frequency response to the whisker stimulus...
  34. pmc Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas
    B M Hooks
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America
    PLoS Biol 9:e1000572. 2011
    ..Local excitatory circuits in different cortical areas are organized around a prominent descending pathway from L2/3→L5, suggesting that sensory cortices are elaborations on a basic motor cortex-like plan...
  35. ncbi Encoding of whisker vibration by rat barrel cortex neurons: implications for texture discrimination
    Ehsan Arabzadeh
    Cognitive Neuroscience Sector, International School for Advanced Studies, 34014 Trieste, Italy
    J Neurosci 23:9146-54. 2003
    ..We conclude that vibration kinetics are rapidly and reliably encoded in the firing rate of cortical ensembles. Therefore, the cortical representation of vibration speed could underlie texture discrimination...
  36. ncbi Functional architecture of the mystacial vibrissae
    M Brecht
    Tubingen University, Germany
    Behav Brain Res 84:81-97. 1997
    We investigated the transduction operation and function of the mystacial vibrissae, using a comparative morphological analysis and behavioral experiments in rats...
  37. ncbi Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons
    Qian Quan Sun
    Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California 94305, USA
    J Neurosci 26:1219-30. 2006
    ..The ready activation of FS cells by TC inputs, coupled with powerful feedforward inhibition from these neurons, would profoundly influence sensory processing and constrain runaway excitation in vivo...
  38. ncbi Absence of rapid sensory adaptation in neocortex during information processing states
    Manuel A Castro-Alamancos
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neuron 41:455-64. 2004
    ..The primary sensory thalamocortical pathway of alert and expectant animals is in the adapted state, which may be required for adequate sensory information processing...
  39. pmc Dimensions of a projection column and architecture of VPM and POm axons in rat vibrissal cortex
    Verena C Wimmer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2265-76. 2010
    ..Finally, we present anatomical dimensions of "TC projection domains" for a standard column in S1...
  40. pmc Feedback control in active sensing: rat exploratory whisking is modulated by environmental contact
    Ben Mitchinson
    Department of Psychology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Proc Biol Sci 274:1035-41. 2007
    ..That whisking pattern generation is under strong feedback control has important implications for understanding the nature of the signals reaching upstream neural processes...
  41. ncbi Simulation of signal flow in 3D reconstructions of an anatomically realistic neural network in rat vibrissal cortex
    Stefan Lang
    Digital Neuroanatomy, Max Planck Florida Institute, 5353 Parkside Drive, MC19 RE, Jupiter, FL 33458 2906, USA
    Neural Netw 24:998-1011. 2011
    ..Our simulations provide insights of how anatomical parameters, such as the subcellular organization of synapses, may constrain spiking responses at the cellular and network levels...
  42. pmc Functional circuitry involved in the regulation of whisker movements
    Alexis M Hattox
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Comp Neurol 442:266-76. 2002
    ....
  43. ncbi Organization of rat vibrissa motor cortex and adjacent areas according to cytoarchitectonics, microstimulation, and intracellular stimulation of identified cells
    Michael Brecht
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    J Comp Neurol 479:360-73. 2004
    ..We suggest that both the strong myelinization and the expanded layer 5 of area AGm may represent cytoarchitectonic specializations related to control of high-speed whisking behavior...
  44. pmc The mechanical variables underlying object localization along the axis of the whisker
    Lorenz Pammer
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    J Neurosci 33:6726-41. 2013
    ..More generally, our data imply that mice can measure the amplitudes of forces in the sensory follicles for tactile sensation...
  45. pmc Restricting dietary magnesium accelerates ectopic connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-) )
    Qiujie Jiang
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Exp Dermatol 21:694-9. 2012
    ..The control of mineralization by dietary magnesium may have broader implications in general population in the context of vascular mineralization...
  46. pmc Whisking and whisker kinematics during a texture classification task
    Yanfang Zuo
    International School for Advanced Studies SISSA, Cognitive Neuroscience Sector, Italian Institute of Technology SISSA unit, via Bonomea 265, 34136 Trieste, Italy
    Philos Trans R Soc Lond B Biol Sci 366:3058-69. 2011
    Rats explore objects by rhythmically whisking with their vibrissae. The goal of the present study is to learn more about the motor output used by rats to acquire texture information as well as the whisker motion evoked by texture contact...
  47. pmc Cortical excitation and inhibition following focal traumatic brain injury
    Ming chieh Ding
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 31:14085-94. 2011
    ....
  48. pmc Neuronal basis for object location in the vibrissa scanning sensorimotor system
    David Kleinfeld
    Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 72:455-68. 2011
    ..Behavioral evidence shows that these animals maintain knowledge of the azimuthal position of their vibrissae. Electrophysiological measurements have identified a reafferent signal of the azimuth that is coded in ..
  49. pmc Vibrissae motor cortex unit activity during whisking
    Wendy A Friedman
    Department of Psychology, Hunter College, City University of New York, New York, USA
    J Neurophysiol 107:551-63. 2012
    ..However, the relatively large vibrissae representation in motor cortex (vMCx) suggests that cortex also contributes to the control of whisker movements...
  50. pmc Dynamic correlation between whisking and breathing rhythms in mice
    Ying Cao
    Department Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 32:1653-9. 2012
    ..High-frequency whisking and sniffing behaviors are not correlated. We conclude that whisking and respiratory rhythms are generated by independent pattern-generating mechanisms...
  51. pmc Connective tissue mineralization in Abcc6-/- mice, a model for pseudoxanthoma elasticum
    N Beril Kavukcuoglu
    Department of Bioengineering, Temple University, Philadelphia, PA 19122, USA
    Matrix Biol 31:246-52. 2012
    ..These results provide critical information of the mechanisms of mineralization in PXE, with potential pharmacologic implications...
  52. ncbi Whisker sensory system - from receptor to decision
    Mathew E Diamond
    Cognitive Neuroscience Sector, International School for Advanced Studies, Trieste, Italy
    Prog Neurobiol 103:28-40. 2013
    ..Finally, we present hypotheses for mechanisms through which "downstream" brain regions may read out the activity of sensory cortex in order to extract the significance of sensory stimuli and, ultimately, to select the appropriate action...
  53. pmc Cortical control of a whisking central pattern generator
    Nathan P Cramer
    Program in Neuroscience and the Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Neurophysiol 96:209-17. 2006
    ..In addition, whisking frequency was correlated with the firing rate of these motoneurons. These findings support the hypothesis that vMCx regulates whisking through its actions on a subcortical CPG...
  54. ncbi Object localization with whiskers
    Ehud Ahissar
    The Department of Neurobiology, Weizmann Institute for Science, Rehovot 76100, Israel
    Biol Cybern 98:449-58. 2008
    ..Such decoding reduces ambiguity, and simplifies the required decoding algorithms, since different readout circuits can be optimized for a particular variable...
  55. ncbi Long-term culture of mouse vibrissal dermal papilla cells and de novo hair follicle induction
    Aki Osada
    Department of Tissue Regeneration, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo, Japan
    Tissue Eng 13:975-82. 2007
    ..The outgrowing DP cells from mouse vibrissae were markedly stimulated by 10% fetal bovine serum-Dulbecco's modified essential medium that included fibroblast ..
  56. ncbi Harbor seal vibrissa morphology suppresses vortex-induced vibrations
    Wolf Hanke
    Institute for Biosciences, Department of Sensory and Cognitive Ecology, Marine Science Center, University of Rostock, 18059 Rostock, Germany
    J Exp Biol 213:2665-72. 2010
    Harbor seals (Phoca vitulina) often live in dark and turbid waters, where their mystacial vibrissae, or whiskers, play an important role in orientation...
  57. pmc Changes in S1 neural responses during tactile discrimination learning
    Michael C Wiest
    Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
    J Neurophysiol 104:300-12. 2010
    ..In summary, the operant behavioral context changes S1 tactile responses even in the absence of tactile discrimination, whereas subsequent width discrimination learning refines the S1 representation of aperture-width...
  58. ncbi Synthesis of multiwhisker-receptive fields in subcortical stations of the vibrissa system
    Elena Timofeeva
    Centre de Recherche Universite Laval Robert Giffard, 2601 de la Canardiere, Quebec G1J 2G3, Canada
    J Neurophysiol 91:1510-5. 2004
    ..07 whisker after the lesion. Together these results indicate that the synthesis of surround receptive fields in subcortical stations relies almost exclusively on intersubnuclear projections from the spinal trigeminal complex to the PrV...
  59. pmc Diffuse traumatic brain injury initially attenuates and later expands activation of the rat somatosensory whisker circuit concomitant with neuroplastic responses
    Kelley D Hall
    Spinal Cord and Brain Injury Research Center, Chandler Medical Center, University of Kentucky, USA
    Brain Res 1323:161-73. 2010
    ..Therapeutic interventions to promote adaptive circuit restructuring may mitigate post-traumatic morbidity...
  60. pmc Neuronal encoding of texture in the whisker sensory pathway
    Ehsan Arabzadeh
    Cognitive Neuroscience Sector, International School for Advanced Studies Trieste Italy
    PLoS Biol 3:e17. 2005
    ..Rats make extremely fine discriminations of texture by "whisking" their vibrissae across an object's surface, yet the neuronal coding underlying texture sensations remains unknown...
  61. ncbi Divergent movement of adjacent whiskers
    Robert N S Sachdev
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurophysiol 87:1440-8. 2002
    ..We conclude that, although whiskers often move in concert, adjacent caudal whiskers can be moved independently of each other...
  62. ncbi Mechanical characteristics of rat vibrissae: resonant frequencies and damping in isolated whiskers and in the awake behaving animal
    Mitra J Hartmann
    Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109, USA
    J Neurosci 23:6510-9. 2003
    ..We discuss the potential roles of resonance during natural exploratory behavior and specifically suggest that resonant oscillations may be important in the rat's tactile detection of object boundaries...
  63. pmc Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis
    Alexandra Van Keymeulen
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, Brussels B 1070, Belgium
    J Cell Biol 187:91-100. 2009
    ..Our study demonstrates that MCs arise from the epidermis by an Atoh1-dependent mechanism and opens new avenues for study of MC functions in sensory perception, neuroendocrine signaling, and MC carcinoma...
  64. pmc Robust temporal coding in the trigeminal system
    Lauren M Jones
    Program in Neuroscience and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 304:1986-9. 2004
    ..These predictions are significantly improved by integrating responses from neurons with opposite angular preferences...
  65. ncbi Orthogonal coding of object location
    Per Magne Knutsen
    Department of Neurobiology, Weizmann Institute for Science, Rehovot 76100, Israel
    Trends Neurosci 32:101-9. 2009
    ..One advantage of such a same-neuron-different-codes scheme over the traditionally assumed same-code-different-neurons scheme is a reduction of code ambiguity that, in turn, simplifies decoding circuits...
  66. ncbi Motor control by sensory cortex
    Ferenc Matyas
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Science 330:1240-3. 2010
    ..Motor control by sensory cortex suggests the need to reevaluate the functional organization of cortical maps...
  67. pmc Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex
    J Berwick
    Department of Psychology, University of Sheffield, Sheffield S10 2TN, UK
    J Neurophysiol 99:787-98. 2008
    ..These data confirm hemodynamics are capable of providing accurate "single-condition" maps of neural activity...
  68. ncbi Hydrodynamic trail-following in harbor seals (Phoca vitulina)
    G Dehnhardt
    Institut fur Zoologie, Universitat Bonn, Poppelsdorfer Schloss, D 53115 Bonn, Germany
    Science 293:102-4. 2001
    ..Here we show that blindfolded seals can use their whiskers to detect and accurately follow hydrodynamic trails generated by a miniature submarine. This shows that hydrodynamic information can be used for long-distance prey location...
  69. pmc Thalamic synchrony and the adaptive gating of information flow to cortex
    Qi Wang
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
    Nat Neurosci 13:1534-41. 2010
    ..The results here suggest a shift in coding strategy with adaptation that directly controls information relayed to cortex, which could have implications for encoding velocity signatures of textures...
  70. pmc Sensory inputs from whisking movements modify cortical whisker maps visualized with functional magnetic resonance imaging
    Benito de Celis Alonso
    MRC Centre for Neurodegeneration Research, King s College London, DeCrespigny Park, London SE5 8AF, UK
    Cereb Cortex 18:1314-25. 2008
    ..Negative BOLD responses were robust at 10 Hz but were weaker or absent with 7-Hz or 3-Hz deflection. Our findings suggest that sensory inputs attributable to the frequency of whisking movements modify whisker cortical representations...
  71. ncbi Shift in the balance between excitation and inhibition during sensory adaptation of S1 neurons
    Jaime E Heiss
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    J Neurosci 28:13320-30. 2008
    ..The differential adaptation of the evoked conductances that shifts the balance toward excitation may act as a gain mechanism which enhances the subthreshold response during sustained stimulation, despite a large reduction in excitation...
  72. pmc Development of columnar topography in the excitatory layer 4 to layer 2/3 projection in rat barrel cortex
    Kevin J Bender
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 23:8759-70. 2003
    ..Thus, development of this projection does not require normal sensory experience after P8, and deprivation-induced reorganization of whisker maps at this age is unlikely to involve physical remodeling of L4 to L2/3 axons...
  73. pmc Tactile guidance of prey capture in Etruscan shrews
    Farzana Anjum
    Department of Neuroscience, Erasmus Medical Center, Postbus 1738, 3000 DR Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 103:16544-9. 2006
    ..Thus, tactile object recognition in Etruscan shrews shares characteristics of human visual object recognition, but it proceeds faster and occurs in a 20,000-times-smaller brain...
  74. pmc Superior colliculus control of vibrissa movements
    Marie E Hemelt
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Neurophysiol 100:1245-54. 2008
    This study tested the role of the superior colliculus in generating movements of the mystacial vibrissae--whisking...
  75. ncbi Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release
    A M Persico
    Laboratory of Neuroscience, Università Campus Bio Medico, 00155 Rome, Italy
    J Neurosci 21:6862-73. 2001
    ..Transient 5-HTT expression is thus required for barrel pattern formation, whereas activity-dependent vesicular 5-HT release is not...
  76. pmc Texture coding in the rat whisker system: slip-stick versus differential resonance
    Jason Wolfe
    Department of Physics, University of California San Diego, La Jolla, California, United States of America
    PLoS Biol 6:e215. 2008
    Rats discriminate surface textures using their whiskers (vibrissae), but how whiskers extract texture information, and how this information is encoded by the brain, are not known...
  77. pmc Active touch sensing in the rat: anticipatory and regulatory control of whisker movements during surface exploration
    Robyn A Grant
    The University of Sheffield, Department of Psychology, Western Bank, Sheffield S10 2TN, UK
    J Neurophysiol 101:862-74. 2009
    ....
  78. ncbi Haptic object localization in the vibrissal system: behavior and performance
    Per Magne Knutsen
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurosci 26:8451-64. 2006
    ....
  79. ncbi Discriminative whisking in the head-fixed rat: optoelectronic monitoring during tactile detection and discrimination tasks
    M A Harvey
    Biopsychology Program, Hunter College, CUNY, New York, NY 10021, USA
    Somatosens Mot Res 18:211-22. 2001
    ..a) head movements are excluded and (b) exposure to tactile discriminanda is confined to the large, moveable vibrissae (macrovibrissae)...
  80. ncbi Right-left asymmetries in the whisking behavior of rats anticipate head movements
    R Blythe Towal
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208 3107, USA
    J Neurosci 26:8838-46. 2006
    Rats use rhythmic movements of their vibrissae (whiskers) to tactually explore their environment...
  81. ncbi Behavioral properties of the trigeminal somatosensory system in rats performing whisker-dependent tactile discriminations
    D J Krupa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 21:5752-63. 2001
    ..required rats to discriminate the width of either a wide or narrow aperture using only their large mystacial vibrissae. Rats quickly acquired this task and could accurately discriminate between apertures of very similar width...
  82. ncbi Discrimination of vibrotactile stimuli in the rat whisker system: behavior and neurometrics
    Todor V Gerdjikov
    Werner Reichardt Center for Integrative Neuroscience, University of Tubingen, 72076 Tübingen Germany
    Neuron 65:530-40. 2010
    ..In conclusion, we suggest that stimulus mean absolute velocity, encoded in primary afferent spike counts, plays a prominent role for whisker-mediated perception...
  83. ncbi New patterns of intracortical projections after focal cortical stroke
    S T Carmichael
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurobiol Dis 8:910-22. 2001
    ..Thus, after focal cortical stroke, the peri-infarct cortex is structurally abnormal, loses thalamic connections, and develops new horizontal cortical connections by axonal sprouting...
  84. ncbi Whisker deafferentation and rodent whisking patterns: behavioral evidence for a central pattern generator
    P Gao
    Biopsychology Program, Hunter College, City University of New York, New York, New York 10021, USA
    J Neurosci 21:5374-80. 2001
    ..These findings provide strong behavioral evidence for a whisking CPG and are discussed in relation to its possible location and properties...
  85. ncbi Topography of rodent whisking--I. Two-dimensional monitoring of whisker movements
    Roberto Bermejo
    Biopsychology Program, Hunter College, CUNY, New York, NY 10021, USA
    Somatosens Mot Res 19:341-6. 2002
    ..monitoring techniques with high-spatio-temporal resolution, movement data were obtained from a population of vibrissae sampled at different locations on the mystacial pad in head-fixed rats isolated from the perturbing effects of ..
  86. ncbi Serotonin regulates rhythmic whisking
    Alexis Hattox
    Department of Anatomy and Neurobiology and The Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neuron 39:343-52. 2003
    ..These findings suggest that serotonin is both necessary and sufficient to generate rhythmic whisker movements and that serotonergic premotoneurons are part of a whisking CPG...
  87. pmc Cortical sensory suppression during arousal is due to the activity-dependent depression of thalamocortical synapses
    Manuel A Castro-Alamancos
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Physiol 541:319-31. 2002
    ..Thalamocortical suppression may serve as a mechanism to focus sensory inputs to their appropriate representations in neocortex, which is helpful for the spatial processing of sensory information...
  88. pmc Motor modulation of afferent somatosensory circuits
    SooHyun Lee
    Department of Neurobiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 11:1430-8. 2008
    ..During voluntary movement, sensory activity may be globally suppressed in the brainstem, whereas signaling by cortically facilitated VPm neurons is simultaneously enhanced relative to other VPm neurons receiving no such facilitation...
  89. ncbi Biomechanical models for radial distance determination by the rat vibrissal system
    J Alexander Birdwell
    Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208 3111, USA
    J Neurophysiol 98:2439-55. 2007
    ..We interpret these results in the context of our evolving hypothesis that neural responses in Vg can be represented using a state-encoding scheme that includes combinations of these four variables...
  90. ncbi Processing in layer 4 of the neocortical circuit: new insights from visual and somatosensory cortex
    K D Miller
    Departments of Physiology and Otolaryngology, WM Keck Center for Integrative Neuroscience, Sloan Swartz Center for Theoretical Neurobiology at UCSF, University of California, San Francisco, CA 94143 0444, USA
    Curr Opin Neurobiol 11:488-97. 2001
    ..Feed-forward inhibition dominates excitation, inherits its tuning from the thalamic input, and sharpens the tuning of excitatory cells. Recurrent excitation enhances responses to effective stimuli...
  91. pmc Interdigitated paralemniscal and lemniscal pathways in the mouse barrel cortex
    Ingrid Bureau
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
    PLoS Biol 4:e382. 2006
    ..L2 neurons received input from lemniscal L3 cells and paralemniscal L5A cells spread over multiple columns. Our data indicate that lemniscal and paralemniscal information is segregated into interdigitated cortical layers...
  92. ncbi Heterogeneity in the coding in rat barrel cortex of the velocity of protraction of the macrovibrissae
    R Rajan
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Eur J Neurosci 25:2383-403. 2007
    ..The effect of amplitude of deflection upon neural responses was evident in only approximately 24% of units and only when the dominant velocity effect had saturated...
  93. ncbi Neural activity in barrel cortex underlying vibrissa-based object localization in mice
    Daniel H O'Connor
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 67:1048-61. 2010
    ..Approximately 13,000 spikes per activated barrel column were available to mice for decision making. Coding of object location in the barrel cortex is therefore highly redundant...
  94. ncbi Unsupervised quantification of whisking and head movement in freely moving rodents
    Igor Perkon
    Cognitive Neuroscience Sector, International School for Advanced Studies, Trieste, Italy
    J Neurophysiol 105:1950-62. 2011
    ..The program adapts automatically to the size and shape of different species. The outcome of our testing indicates that the program can be a valuable tool in quantifying rodent sensorimotor behavior...
  95. pmc Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling
    Aneurin J Kennerley
    Department of Psychology, University of Sheffield, Sheffield, UK
    J Cereb Blood Flow Metab 32:468-80. 2012
    ..Although data did not clearly dissociate early and late vascular responses, they suggest that the neurovascular coupling relationship is neurogenic in origin...
  96. ncbi Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process
    Qiaoli Li
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Exp Dermatol 16:853-9. 2007
    ....
  97. ncbi Septal neurons in barrel cortex derive their receptive field input from the lemniscal pathway
    Takahiro Furuta
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Neurosci 29:4089-95. 2009
    ..This result provides the missing piece of evidence for a separate pathway of vibrissal information that projects to septal columns of the barrel cortex...
  98. ncbi A novel stimulus system for applying tactile stimuli to the macrovibrissae in electrophysiological experiments
    R Rajan
    Department of Physiology, Monash University, Wellington Road, Monash, VIC 3800, Australia
    J Neurosci Methods 157:103-17. 2006
    The rat's vibrissae are a wonderful system for the study of sensory neural encoding in relation to behaviour because the vibrissae are easily identifiable and accessible for manipulation, allowing easy application of a variety of ..
  99. pmc Comparison of rat sensory behavioral tasks to detect somatosensory morbidity after diffuse brain-injury
    Annastazia Ellouise Learoyd
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    Behav Brain Res 226:197-204. 2012
    ....
  100. pmc Whisker isotopic signature depicts migration patterns and multi-year intra- and inter-individual foraging strategies in fur seals
    Y Cherel
    Centre d Etudes Biologiques de Chize, UPR 1934 du CNRS, 79360 Villiers en Bois, France
    Biol Lett 5:830-2. 2009
    ..The isotopic signature of whiskers, therefore, revealed new multi-year foraging strategies of male Antarctic fur seals and is a powerful tool for investigating the ecological niche during cryptic stages of mammals' life...
  101. pmc Neurodegeneration in the somatosensory cortex after experimental diffuse brain injury
    Jonathan Lifshitz
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Office B463, Biomedical and Biological Sciences Research Building, 741 S Limestone St, Lexington, KY 40536 0509, USA
    Brain Struct Funct 217:49-61. 2012
    ..The rodent whisker barrel circuit may serve as a discrete model to evaluate the causes and consequences of circuit reorganization after diffuse brain injury...

Research Grants62

  1. Regulatory architecture of the Androgen Receptor locus in development & evolution
    Philip L Reno; Fiscal Year: 2010
    ..show that the homologous chimpanzee and mouse sequences drive reproducible expression in the developing facial vibrissae and genital tubercle, two anatomical locations, where humans are also morphologically distinct from most other ..
  2. Sensorimotor loops in vibrissa somatosensation
    David Kleinfeld; Fiscal Year: 2013
    ..sensory input within the closed loops of the vibrissa sensorimotor system, in which animals sweep long hairs or vibrissae rhythmically through the space that surrounds their head,...
  3. ETHANOL EFFECT ON THE BASAL FOREBRAIN CORTEX SYSTEM
    Michael Miller; Fiscal Year: 1999
    ..the basal forebrain and in the barrels of somatosensory cortex (segments which receive input from the mystacial vibrissae) will be determined using rigorous morphometric analyses...
  4. Pre-motor Neural Circuits for Exploratory Movement
    Fan Wang; Fiscal Year: 2013
    ..Rodents explore their physical environment through rhythmic sweeping of their vibrissae ("whisking"), and thus serve as a major model for studying neural circuits controlling exploratory touch ..
  5. TRIGEMINOHYPOTHALAMIC TRACT
    Rami Burstein; Fiscal Year: 1999
    ..responsiveness to stimulation of external and internal structures In the face and cranium (skin, cornea, dura, vibrissae, oral mucous, nasal mucous etc...
  6. The development of topographic maps and connectivity in M1 and S1 of rats
    ADELE MARY HANDLEY SEELKE; Fiscal Year: 2010
    ..The area of the cortical sheet dedicated to different body representations (including the head/vibrissae, trunk, forelimbs, and hindlimbs) will be calculated at each age, and compared across ages, to determine how the ..
  7. LOCUS COERULEUS MODULATION OF SENSORY NETWORK FUNCTION
    Barry Waterhouse; Fiscal Year: 2002
    ..and tissue slice preparations, electrical and chemical activation of LC, mechanical stimulation of the mystacial vibrissae and computer-based analysis of spike train data (in vivo studies) or membrane potential changes (in vitro ..
  8. COCAINE, SEROTONIN, AND CORTICAL DEVELOPMENT
    CAROL BENNETT CLARKE; Fiscal Year: 2000
    ..We will test this hypothesis in the vibrissae representation of the rat's primary somatosensory cortex, the most well-studied cortical area in rodents, and ..
  9. Experience-Dependent Enhancement of Neuronal Integration
    ARTHUR CZUPRYN; Fiscal Year: 2006
    ..area (enriched environment) or by intense forced movement of tactile whiskers (mechanical stimulation of vibrissae)...
  10. SENSORY REORGANIZATION--METABOLIC, BEHAVIORAL ALTERATION
    Peter Hand; Fiscal Year: 1992
    ..functional representation of facial vibrissa C3, which is spared (SC3) following denervation of remaining vibrissae, will be examined at all levels of the vibrissa-SI cortex pathway of neonatal and adult rats under different ..
  11. Enhancing recovery of sensation after cerebral ischemia
    John Hoffman; Fiscal Year: 2005
    ..The mystacial vibrissae of the rat, with their corresponding representation in the somatosensory cortex, provides an ideal vehicle for ..
  12. FMRI OF NEURAL CIRCUITS IN EYEBLINK CONDITIONING
    Alice Wyrwicz; Fiscal Year: 2002
    ..First, the hemodynamic activation of three different stimulus pathways (light and vibrissae/touch conditioned stimulus (CS) and corneal air puff unconditioned stimulus (US)) will be examined with fMRI...
  13. PATCHED GENE FUNCTION DURING VERTEBRATE SKIN DEVELOPMENT
    ANTHONY ORO; Fiscal Year: 2000
    ..We aim to examine Shh and ptc expression during normal skin development and regenerating vibrissae to make predictions regarding function...
  14. TRIGEMINAL PRIMARY AFFERENT DEVELOPMENT
    ROBERT RHOADES; Fiscal Year: 1999
    ..will use fetal surgical techniques to damage the peripheral axons of primary afferents that innervate selected vibrissae follicles...
  15. Sprouting & CNS plasticity in Nogo & NgR mutant mice
    Aaron McGee; Fiscal Year: 2005
    ..The plasticity of the vibrissae (whisker) representations (barrels) in somatosensory cortex may be aberrant these mice...
  16. Ischemia Induced Plasticity - Implications for Therapy
    Joel Greenberg; Fiscal Year: 2005
    ..of the rat, and reorganization will be evaluated by examining the changes in the blood flow response maps to vibrissae stimulation...
  17. Phase Dynamics in a Brainstem Sensorimotor Feedback Loop
    Quoc Thang Nguyen; Fiscal Year: 2006
    ..of the VTF circuit in the closed-loop configuration in which a neuromorphic circuit that plays the role of vibrissae.3) develop, in collaboration with Prof...
  18. Neurophysiological Basis of Functional MRI Signals
    Alice Wyrwicz; Fiscal Year: 2006
    ..Stimulation of the well-characterized vibrissae barrel system will be used in the first paradigm to examine the dependence of response properties on stimulation ..
  19. Functional Organization of Somatosensory Cortex
    KEVIN ALLOWAY; Fiscal Year: 2007
    ..To address this issue, conditional cross-correlation analysis will be used to quantify the impact of synchronized activity in SI on the probability of neuronal responsiveness in corresponding parts of the MI whisker representation. ..
  20. Somatosensory Cortical Influences on Subcortical Processing
    KEVIN ALLOWAY; Fiscal Year: 2007
    ..Aim 4. Support or refute the hypothesis that stimulus-induced neuronal activity in SI barrel cortex and the pons are more strongly correlated than stimulus-induced activity in SI cortex and the neostriatum. ..
  21. Somatosensory Cortical Influences on Subcortical Processing
    KEVIN DOUGLAS ALLOWAY; Fiscal Year: 2010
    ....
  22. Multi-scale mapping of 3D spatial-temporal cortical hemodynamics at the level of
    David Kleinfeld; Fiscal Year: 2008
    ..It will help define optical- and MRI-based diagnostics for the detection of dysfunction and clinically appropriate interventionist therapies. [unreadable] [unreadable] [unreadable]..
  23. Sentinel cells that report neural and neurovascular signaling
    David Kleinfeld; Fiscal Year: 2008
    ..The assay has wide ranging applications, including, but not limited to research on abused substances. [unreadable] [unreadable] [unreadable]..
  24. DEEP MULTI-PHOTON IMAGING OF BRAIN STRUCTURE & FUNCTION
    David Kleinfeld; Fiscal Year: 2002
    ....
  25. Surgical Management of Facial Nerve Injury
    Theresa Hadlock; Fiscal Year: 2007
    ..The academic environment is one of complete dedication to advancing both biomedical science and patient care through careful study and diligent investigation, and of support for the mentored investigator. [unreadable] [unreadable]..
  26. OPTICAL IMAGER FOR ELECTRICAL DYNAMICS IN CORTEX
    David Kleinfeld; Fiscal Year: 2001
    ..These proposed studies of stimulus representation in the rat vibrissa sensorimotor pathway will serve as a scientific test-bed for the proposed technology. ..
  27. All-Optical Histology for 3-D Cortical Reconstructions
    David Kleinfeld; Fiscal Year: 2006
    ..We will make this tool readily available to the biomedical community. The proposed model system may substantially improve upon our understanding of the large-scale structure of brain architectonics. ..
  28. Effects of Methylphenidate on Catecholamine Transmission
    David Devilbiss; Fiscal Year: 2005
    ....
  29. MOTOR MODULATION OF SENSORY INPUT IN RAT VIBRISSA CORTEX
    David Kleinfeld; Fiscal Year: 2003
    ..in the context of tactile localization of objects accomplished by the exploratory whisking movements of vibrissae in the rat...
  30. Femtosecond Light to Manipulate Neurons and Vasculature
    David Kleinfeld; Fiscal Year: 2007
    ..Fortype specifications, see instructions on page6.) ; RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  31. Experience Dependent Plasticity of The Developing Cortex
    RON FROSTIG; Fiscal Year: 2007
    ..Further, such results would help in reassessment of the appropriateness of SC-raised rats to serve as models for the normal human brain. ..
  32. Behaviorally Induced Cortical Plasticity
    RON FROSTIG; Fiscal Year: 2006
    ..In addition, such findings could have important implications for treatment of adult perceptual/motor disorders. [unreadable] [unreadable]..
  33. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2010
    ..abstract_text> ..
  34. MECHANISM UNDERLYING NGF-INDUCED CORTICAL PLASTICITY
    RON FROSTIG; Fiscal Year: 2003
    ..abstract_text> ..
  35. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2010
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  36. Attentional Regulation of Plasticity in Auditory Cortex
    Daniel Polley; Fiscal Year: 2004
    ..abstract_text> ..
  37. A Magnetoencephalography Study: Saccadic Eye Movement Effects on Word Processing
    SIMONA TEMEREANCA IBANESCU; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. DEVELOPMENT OF THE CORTICOTHALAMIC SYSTEM
    Edward Jones; Fiscal Year: 2003
    ..Defective maturation may be a concomitant of or a basis for certain forms of seizures in young individuals. ..
  39. The organization and plasticity of cortical areas representing the dentition
    KENNETH CATANIA; Fiscal Year: 2009
    ..The long-term goal of these experiments is to identify general principles of brain organization and plasticity. ..
  40. Corticothalamic Neurons in Sensorimotor Cortex
    Daniel J Simons; Fiscal Year: 2010
    ..The research plan should lead to new insights into how - and perhaps, why - the cerebral cortex regulates its own activity during information processing states. ..
  41. Mechanisms of Neuronal Regeneration after Stroke in a Novel Neurovascular Niche
    STANLEY THOMAS CARMICHAEL; Fiscal Year: 2010
    ..An understanding of the molecules that promote this neural stem cell response after stroke will help develop novel therapies to promote replacement of brain cells in this disease. ..
  42. Abused NMDA Antagonists: Effects on Cortical Development
    Mary Wilson; Fiscal Year: 2004
    ..Based on our previous experience, the rodent barrel field model should provide a powerful, highly sensitive assessment of the potential impact of these abused drugs on neocortical development and plasticity. ..
  43. IMAGING OF INTRACRANIAL HEMATOMAS BY DIFFUSE TOMOGRAPHY
    David Boas; Fiscal Year: 2002
    ....
  44. NUTRITIONAL COPPER STATUS AND THE NERVOUS SYSTEM
    JOSEPH ROBERT PROHASKA; Fiscal Year: 2010
    ..AIM 4: We will test the hypothesis that limitation in Cu-dependent ferroxidases lead to lower brain iron and are responsible by comparing rats reared on an iron-fortified diet to restore brain iron. ..
  45. ADVANCED OPTICAL IMAGE PROBE FOR NEUROPHYSIOLOGY
    David Rector; Fiscal Year: 2009
    ..Accomplishment of these new goals is crucial to moving optical techniques into more practical applications that image electrical correlates of neural activity with better signal-to-noise. ..
  46. An Experimental Model of White Matter Infarct
    SHAWN FROST; Fiscal Year: 2008
    ..This will be an important, and unique, animal model for research into pharmaceutical and physical therapeutic effects on recovery of function following white matter infarct and subcortical stroke. [unreadable] [unreadable] [unreadable]..
  47. Basal ganglia modulation of trigeminal intralaminar nuclei thalamic activity
    Eric Chudler; Fiscal Year: 2007
    ..These studies will help explain the complex sensory symptoms exhibited by patients with PD and may suggest new treatment strategies to alleviate such pain. [unreadable] [unreadable] [unreadable]..
  48. STEM CELL FACTOR ACTION IN NEURAL CREST DEVELOPMENT
    Maya Sieber Blum; Fiscal Year: 2003
    ..However, the newly detected additional roles of SCF in maintaining stem cells, up-regulating neurotrophin receptors and promoting sensory neurogenesis suggest additional defects in human piebaldism that remain to be elucidated. ..
  49. Regulation Trigeminal Neuron Differentiation&Projection
    Qiufu Ma; Fiscal Year: 2005
    ..These sublineage-specific genes will be candidate molecules that control cell subtype specification. ..
  50. Novel Technologies For Skin-Specific Gene Expression
    JOHN KLEMENT; Fiscal Year: 2003
    ..Thus these procedures, if rendered into practice, could serve as a quick and relatively easy method to determine proof-of-principle for gene therapy applications. ..
  51. DYNAMICAL PROPERTIES OF THALAMIC PROCESSING CIRCUITS
    Daniel Simons; Fiscal Year: 2003
    ....
  52. 2005 (Oculomotor System Biology) Gordon Conference
    Neeraj Gandhi; Fiscal Year: 2005
    ..Hence, we seek to bring together ideas and investigators that are not often at the same venue. ..
  53. Amygdala Response to Experimental Traumatic Brain Injury
    Jonathan Lifshitz; Fiscal Year: 2005
    ..This research effort may lead to novel treatments for the affective disorders in an otherwise healthy brain-injured population, in addition to post-traumatic stress disorder and psychosis. ..
  54. Multi-photon and fluorescence-lifetime microscope for in-vivo functional imaging
    David Boas; Fiscal Year: 2006
    ..This system will be an invaluable resource for the many interdisciplinary research projects within the Martinos center, in the surrounding MGH community, and for many others in the greater Boston area. [unreadable] [unreadable]..
  55. FUNCTIONAL NEUROANATOMY OF MOVEMENT DISORDERS
    Lucy Brown; Fiscal Year: 2006
    ..The studies may provide clues to the function of the gene huntingtin, and define a target for therapeutic strategies. In addition, these studies address the plastic and proliferative capacity of the adult brain. ..
  56. Experience Dependent Neocortical Development
    Daniel Simons; Fiscal Year: 2006
    ..and the cellular mechanisms through which they operate is essential for the eventual diagnosis, treatment and prevention of developmental disorders affecting perception, cognition and other higher cortical functions ..
  57. Cortical Representational Plasticity of Oral Structures
    KENNETH CATANIA; Fiscal Year: 2003
    ..abstract_text> ..
  58. 2007 Oculomotor System Biology Gordon Research Conference
    Neeraj Gandhi; Fiscal Year: 2007
    ..Other disorders such as congenital fibrosis can also alter mechanistic properties of the extraocular muscle itself. Hence, the oculomotor system is of immense relevance to health. [unreadable] [unreadable] [unreadable] [unreadable]..
  59. Parkinsonian mouse model: impaired respiratory enzymes
    Lars Olson; Fiscal Year: 2005
    ..2. To determine if respiratory chain dysfunction in DA neurons will induce a PD like phenotype and validate this approach as a new and unique model of Parkinson's Disease. ..
  60. Mechanisms of Axonal Sprouting After Stroke
    STANLEY CARMICHAEL; Fiscal Year: 2007
    ..These experiments will identify neuronal growth programs after stroke, and Iocal inhibitory molecules, and provide an understanding of the mechanisms of regeneration in the adult brain. ..
  61. IRON DEFICIENCY AND DOPAMINE
    John Beard; Fiscal Year: 2004
    ..This expansion of study to other neurotransmitters will significantly contribute to our knowledge of the effects of iron deficiency on brain functioning in early life. ..