yolk sac

Summary

Summary: The first of four extra-embryonic membranes to form during EMBRYOGENESIS. In REPTILES and BIRDS, it arises from endoderm and mesoderm to incorporate the EGG YOLK into the DIGESTIVE TRACT for nourishing the EMBRYO. In placental MAMMALS, its nutritional function is vestigial; however, it is the source of INTESTINAL MUCOSA; BLOOD CELLS; and GERM CELLS. It is sometimes called the vitelline sac, which should not be confused with the VITELLINE MEMBRANE of the egg.

Top Publications

  1. pmc Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
    Guillaume Hoeffel
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
    J Exp Med 209:1167-81. 2012
  2. ncbi Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:62-6. 1995
  3. ncbi The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein
    R Kozyraki
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Nat Med 5:656-61. 1999
  4. ncbi Cell tracing shows the contribution of the yolk sac to adult haematopoiesis
    Igor M Samokhvalov
    Laboratory for Stem Cell Biology, Center for Developmental Biology, RIKEN Kobe, Kobe 650 0047, Japan
    Nature 446:1056-61. 2007
  5. ncbi Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    Todd G Davenport
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2263-73. 2003
  6. ncbi The visceral yolk sac endoderm provides for absorption of nutrients to the embryo during neurulation
    Irene E Zohn
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Birth Defects Res A Clin Mol Teratol 88:593-600. 2010
  7. ncbi Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
    J Palis
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, Box 777, Rochester, NY 14642, USA rochester edu
    Development 126:5073-84. 1999
  8. pmc Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells
    Caihong Qiu
    Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Hematology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 111:2400-8. 2008
  9. pmc Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6
    Nobuyuki Matsumoto
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Ave, Rm 1170F, New York, NY 10029, USA
    Blood 107:1357-65. 2006
  10. ncbi Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
    F Alliot
    UPR CNRS 9035 Développement et Immunité du Système Nerveux Central 15 rue de l Ecole de Médecine, 75270, Paris, France
    Brain Res Dev Brain Res 117:145-52. 1999

Research Grants

Detail Information

Publications245 found, 100 shown here

  1. pmc Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
    Guillaume Hoeffel
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
    J Exp Med 209:1167-81. 2012
    ..Using in vivo lineage tracing, we identify a first wave of yolk sac (YS)-derived primitive myeloid progenitors that seed the skin before the onset of fetal liver hematopoiesis...
  2. ncbi Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:62-6. 1995
    ..Yolk-sac blood islands were absent at 7.5 days, organized blood vessels could not be observed in the embryo or yolk sac at any stage, and haematopoietic progenitors were severely reduced...
  3. ncbi The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein
    R Kozyraki
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Nat Med 5:656-61. 1999
    ..However, several lines of evidence, including a high expression in kidney and yolk sac, indicate it may have additional functions...
  4. ncbi Cell tracing shows the contribution of the yolk sac to adult haematopoiesis
    Igor M Samokhvalov
    Laboratory for Stem Cell Biology, Center for Developmental Biology, RIKEN Kobe, Kobe 650 0047, Japan
    Nature 446:1056-61. 2007
    ..major vitelline and umbilical vessels, and placenta; however, whether they arise locally or from immigrant yolk sac precursor cells remains unclear...
  5. ncbi Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    Todd G Davenport
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2263-73. 2003
    ..in limb and mammary gland development, and, in addition, reveals a previously unknown role for the gene in the yolk sac, a fetal membrane that is the site of hematopoiesis and is essential for survival during gestation...
  6. ncbi The visceral yolk sac endoderm provides for absorption of nutrients to the embryo during neurulation
    Irene E Zohn
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Birth Defects Res A Clin Mol Teratol 88:593-600. 2010
    ..by histotrophic mechanisms and absorbed by endocytosis in the endoderm-derived cell layer of the visceral yolk sac (VYS)...
  7. ncbi Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
    J Palis
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, Box 777, Rochester, NY 14642, USA rochester edu
    Development 126:5073-84. 1999
    ..the transient nature of the primitive erythroid lineage, as progenitors increased in number in the developing yolk sac until early somite-pair stages of development (E8...
  8. pmc Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells
    Caihong Qiu
    Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Hematology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 111:2400-8. 2008
    ..be expanded in serum-free liquid culture into large numbers of megaloblastic nucleated erythroblasts resembling yolk sac-derived cells...
  9. pmc Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6
    Nobuyuki Matsumoto
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Ave, Rm 1170F, New York, NY 10029, USA
    Blood 107:1357-65. 2006
    ..5 and associated with markedly reduced hematopoiesis and poorly organized yolk sac vascularization...
  10. ncbi Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
    F Alliot
    UPR CNRS 9035 Développement et Immunité du Système Nerveux Central 15 rue de l Ecole de Médecine, 75270, Paris, France
    Brain Res Dev Brain Res 117:145-52. 1999
    ..We now report that they can be detected in the brain rudiment from embryonic day 8, after their appearance in the yolk sac and that their number increases until late gestation...
  11. pmc Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential
    Momoko Yoshimoto
    Department of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 108:1468-73. 2011
    ..We demonstrate, using Ncx1(-/-) mice that lack systemic blood circulation, that the E9 yolk sac (YS) and the intra-embryonic para-aortic splanchnopleura (P-Sp) tissues independently give rise to AA4...
  12. ncbi Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo
    Hanna K A Mikkola
    Department of Hematology Oncology, Children s Hospital, Boston, MA, USA
    Blood 101:508-16. 2003
    ..In the mouse embryo, expression of CD41 was detected in yolk sac blood islands and in fetal liver...
  13. pmc Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    Tatsuya Katsuno
    Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Japan
    Mol Biol Cell 19:2465-75. 2008
    ..5. In the yolk sac, the ZO-1 deficiency induced defects in vascular development, with impaired formation of vascular trees, along ..
  14. ncbi Three pathways to mature macrophages in the early mouse yolk sac
    Julien Y Bertrand
    Institut National de la Santé et de la Recherche Médicale INSERM U668, Unité de Développement des Lymphocytes, Institut Pasteur, Paris, France
    Blood 106:3004-11. 2005
    ..Both YS-derived precursors followed a developmental pathway common to adult Mphi and could be qualified as definitive...
  15. ncbi The origin and fate of yolk sac hematopoiesis: application of chimera analyses to developmental studies
    Hiroo Ueno
    Institute of Stem Cell Biology and Regenerative Medicine, Department of Pathology, Ludwig Institute at Stanford University, Stanford University, Stanford, CA, USA
    Int J Dev Biol 54:1019-31. 2010
    During mammalian development, as exemplified by mice, hematopoietic cells first appear in the yolk sac blood islands, then in the dorsal aorta of the aorta-gonad-mesonephros (AGM) region and the placenta, eventually seeding into liver, ..
  16. pmc DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice
    Zixuan Chen
    Department of Physiology, Campbell Clinic, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 287:19018-28. 2012
    ..Blood vessels were absent in the yolk sac of DGCR8 KOs after E12.5...
  17. ncbi Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy
    Graham J Burton
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    J Clin Endocrinol Metab 87:2954-9. 2002
    ..Glycodelin was also detected within the epithelium of the secondary yolk sac lining the exocoelomic cavity, indicating that the yolk sac may play an important role in nutrient exchange ..
  18. pmc The developing chicken yolk sac acquires nutrient transport competence by an orchestrated differentiation process of its endodermal epithelial cells
    Raimund Bauer
    Department of Medical Biochemistry, Medical University of Vienna, Max F Perutz Laboratories, Dr Bohr Gasse 9 2, 1030 Vienna, Austria
    J Biol Chem 288:1088-98. 2013
    During chicken yolk sac (YS) growth, mesodermal cells in the area vasculosa follow the migrating endodermal epithelial cell (EEC) layer in the area vitellina...
  19. ncbi Yolk sac carbohydrate levels and gene expression of key gluconeogenic and glycogenic enzymes during chick embryonic development
    L Yadgary
    Department of Animal Science, The Hebrew University, Rehovot, Israel
    Poult Sci 91:444-53. 2012
    ..mg/g of tissue) and amounts (mg) were determined in the yolks of fertile eggs on the day of set and in the yolk sac (YS) and liver of broiler chick embryos between 11 and 21 embryonic days of age (E)...
  20. ncbi Yolk-sac hematopoiesis: the first blood cells of mouse and man
    J Palis
    University of Rochester, Department of Pediatrics and Cancer Center, Rochester, NY 14642, USA
    Exp Hematol 29:927-36. 2001
    To review the process of blood-cell formation in the murine and human yolk sac.
  21. ncbi Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia
    Rita L C Carvalho
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Development 131:6237-47. 2004
    ..that lack endoglin or activin receptor like kinase (ALK) 1 die at mid-gestation as a result of defects in the yolk sac vasculature...
  22. ncbi The mammalian yolk sac placenta
    Claudia Freyer
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, Australia
    J Exp Zool B Mol Dev Evol 312:545-54. 2009
    There are three fetal membranes in mammals, namely the yolk sac, allantois and amnion, but only the first two form a placenta...
  23. ncbi The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish
    Takuya Sakaguchi
    Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 2711, USA
    Development 133:4063-72. 2006
    ..Based on these data, we propose that the extra-embryonic YSL regulates myocardial migration, at least in part by influencing fibronectin expression and subsequent assembly of the extracellular matrix in embryonic tissues...
  24. ncbi Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    A Donovan
    Department of Medicine, Children s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 403:776-81. 2000
    ..The gene, ferroportin1, encodes a multiple-transmembrane domain protein, expressed in the yolk sac, that is a candidate for the elusive iron exporter...
  25. pmc Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65
    Elizabeth M Morin-Kensicki
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Mol Cell Biol 26:77-87. 2006
    ..5. Phenotypic characterization revealed a requirement for YAP in yolk sac vasculogenesis...
  26. ncbi Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac
    M C Yoder
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Immunity 7:335-44. 1997
    ..Contrary to reports that the preliver yolk sac does not contain definitive HSC, we observed that CD34+ day 9 yolk sac cells repopulated multiple blood cell ..
  27. ncbi The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium
    T C Doetschman
    J Embryol Exp Morphol 87:27-45. 1985
    ..into large cystic structures containing alphafoetoprotein and transferrin, thus being analagous to the visceral yolk sac of the postimplantation embryo...
  28. pmc Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
    L Robb
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 92:7075-9. 1995
    ..75. Histological studies showed complete absence of recognizable hematopoiesis in the yolk sac of these embryos. Early organogenesis appeared to be otherwise normal...
  29. pmc In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus
    M C Yoder
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 702 Barnhill Drive, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 94:6776-80. 1997
    The murine yolk sac, being the first site of embryonic blood cell production, has long been theorized to contain the migrating hematopoietic stem cells (HSC) that seed the liver and initiate hematopoiesis on day 10.0 postcoitus (pc)...
  30. pmc beta8 integrins are required for vascular morphogenesis in mouse embryos
    Jiangwen Zhu
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 129:2891-903. 2002
    ..beta8-deficient embryos die at midgestation, with evidence of insufficient vascularization of the placenta and yolk sac. The remaining 35% die shortly after birth with extensive intracerebral hemorrhage...
  31. ncbi TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
    M Oshima
    Banyu Tsukuba Research Institute Merck, Okubo, Japan
    Dev Biol 179:297-302. 1996
    ..The homozygous Tgfbr2 mutation causes defects in the yolk sac hematopoiesis and vasculogenesis, resulting in an embryonic lethality around 10.5 days of gestation...
  32. ncbi Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: a light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study
    K Takahashi
    Second Department of Pathology, Kumamoto University Medical School, Japan
    J Leukoc Biol 45:87-96. 1989
    Primitive macrophages first appear in the blood islands of the mouse yolk sac on the ninth day of gestation...
  33. pmc Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow
    Jie Zhu
    School of Public Health, Wuhan University, Wuhan, Hubei, P R China
    PLoS ONE 8:e71153. 2013
    ..the effects of hydroquinone (HQ), a major metabolite of benzene in humans and animals, on mouse embryonic yolk sac hematopoietic stem cells (YS-HSCs) and adult bone marrow hematopoietic stem cells (BM-HSCs)...
  34. ncbi The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac
    Tatiana V Cohen
    Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick MD 21702, USA
    Development 134:1385-95. 2007
    ....
  35. ncbi The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C, Denmark
    J Biol Chem 273:5235-42. 1998
    ..The same receptor represents also the yolk sac target for teratogenic antibodies causing fetal malformations in rats...
  36. ncbi Hematopoietic potential of the pre-fusion allantois
    Catherine Corbel
    Institut Cochin, Departement d Hematologie, 123, boulevard de Port Royal, 75014 Paris, France
    Dev Biol 301:478-88. 2007
    ..These results provide evidence that the allantois has hematopoietic potential per se. Whether this potential also involves the ability to produce HSC is still to be determined...
  37. ncbi Initiation of murine embryonic erythropoiesis: a spatial analysis
    L Silver
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, NY 14642, USA
    Blood 89:1154-64. 1997
    ..25 to E8.5), when the conceptus undergoes rapid morphologic changes with formation of the yolk sac and blood islands...
  38. pmc Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence
    Momoko Yoshimoto
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 119:5706-14. 2012
    The extra-embryonic yolk sac (YS) is the first hematopoietic site in the mouse embryo and is thought to generate only primitive erythroid and myeloerythroid progenitor cells before definitive HSC emergence within the embryo on E10.5...
  39. ncbi The chick embryo yolk sac membrane expresses nutrient transporter and digestive enzyme genes
    L Yadgary
    Department of Animal Science, Hebrew University, Rehovot, Israel
    Poult Sci 90:410-6. 2011
    The yolk sac membrane plays a major role in the transport of nutrients from the yolk contents to the chick embryo. We examined whether the yolk sac membrane expresses genes for nutrient digestion, enzymes, and nutrient transporters...
  40. ncbi Intraembryonic, but not yolk sac hematopoietic precursors, isolated before circulation, provide long-term multilineage reconstitution
    A Cumano
    , Institut Pasteur, rue du Dr. Roux, 75724 Paris, France
    Immunity 15:477-85. 2001
    The relative contribution of yolk sac and intraembryonic precursors to hematopoiesis has been a matter of long-standing controversy...
  41. pmc Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
    Christopher P Regan
    Vertex Pharmaceuticals, Department of Biology, 130 Waverly Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:9248-53. 2002
    ..Together, these data define an essential role for Erk5 in cardiovascular development. Moreover, the inability of Erk5-deficient mice to form a complex vasculature suggests that Erk5 may play an important role in controlling angiogenesis...
  42. ncbi Primitive and definitive erythropoiesis in the yolk sac: a bird's eye view
    Guojun Sheng
    Laboratory for Early Embryogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
    Int J Dev Biol 54:1033-43. 2010
    The yolk sac is the sole niche and source of cells for primitive erythropoiesis from E1 to E5 of chicken development. It is also the main niche and source of cells for early definitive erythropoiesis from E5 to E12...
  43. ncbi An unusual feature of yolk sac placentation in Necromys lasiurus (Rodentia, Cricetidae, Sigmodontinae)
    P O Favaron
    Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil
    Placenta 33:578-80. 2012
    We studied the development of the inverted yolk sac in a New World rodent, Necromys lasiurus during early placentation. Ten implantation sites were investigated by means of histology, immunohistochemistry and electron microscopy...
  44. pmc The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development
    Courtney T Griffin
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Development 135:493-500. 2008
    ..Additionally, vascular remodeling of the extraembryonic yolk sac is abnormal in Brg1(fl/fl):Tie2-Cre(+) embryos...
  45. ncbi Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells
    Latasha C Redmond
    Department of Human Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Dev Dyn 237:436-46. 2008
    ..5 yolk sac. The RNA samples were amplified and labeled for hybridization to Affymetrix GeneChip Mouse Genome 430A 2.0 arrays...
  46. ncbi Chorioallantoic and yolk sac placentation in Thrichomys laurentinus (Echimyidae) and the evolution of hystricognath rodents
    Moacir Franco de Oliveira
    Department of Animal Science, Universidade Federal Rural do Semi Arido, Mossoró, Rio Grande do Norte, Brazil
    J Exp Zool B Mol Dev Evol 318:13-25. 2012
    ..organization of the labyrinth and the trophospongium as well as the establishment of the complete inverted yolk sac placenta...
  47. ncbi Evidence for the presence of murine primitive megakaryocytopoiesis in the early yolk sac
    J Xu M
    Department of Clinical Oncology and Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Blood 97:2016-22. 2001
    During mouse embryogenesis, primitive erythropoiesis occurs in blood islands of the yolk sac (YS) on the seventh day of gestation...
  48. ncbi Yolk sac endoderm is the major source of serum proteins and lipids and is involved in the regulation of vascular integrity in early chick development
    Fumie Nakazawa
    Laboratory for Early Embryogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
    Dev Dyn 240:2002-10. 2011
    ..During embryonic development, the yolk sac (YS) endoderm has been suggested to play a similar role...
  49. ncbi AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    T Okuda
    Department of Pathology and Laboratory Medicine, St Jude Children s Research Hospital Memphis, Tennessee 38105, USA
    Cell 84:321-30. 1996
    ..Embryos with homozygous mutations in AML1 showed normal morphogenesis and yolk sac-derived erythropoiesis, but lacked fetal liver hematopoiesis and died around E12.5...
  50. ncbi Mesenchymal progenitor cells from canine fetal tissues: yolk sac, liver, and bone marrow
    Cristiane Valverde Wenceslau
    Department of Surgery, University of Sao Paulo, Sao Paulo, Brazil
    Tissue Eng Part A 17:2165-76. 2011
    ..fetal development, mesenchymal progenitor (MP) cells are co-localized in major hematopoietic territories, such as yolk sac (YS), bone marrow (BM), liver (LV), and others...
  51. ncbi Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity
    Jason M Hansen
    Department of Biochemistry, School of Medicine, Emory University, Atlanta, Georgia, USA
    Birth Defects Res A Clin Mol Teratol 73:72-82. 2005
    ..Methanol (CH3OH) is believed to be teratogenic based on rodent studies. The mouse is more sensitive than the rat, but mechanisms of toxicity and identification of teratogenic metabolites are uncertain...
  52. ncbi Maternal cholesterol in fetal development: transport of cholesterol from the maternal to the fetal circulation
    Laura A Woollett
    Department of Pathology, 2120 East Galbraith Road, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45236 0507, USA
    Am J Clin Nutr 82:1155-61. 2005
    ..of cholesterol from the basolateral side of the placental cells and the secretion of cholesterol from endodermal yolk sac cells to the fetal circulation can be regulated...
  53. ncbi Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver
    Josette Renee Landry
    Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom
    Blood 111:3005-14. 2008
    ..To this end, we generated an Scl(-/-) yolk sac cell line to identify candidate Scl target genes by global expression profiling after reintroduction of a TAT-Scl ..
  54. ncbi Transforming growth factor-beta signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice
    M J Goumans
    Hubrecht Laboratory, Netherlands Institute of Developmental Biology, Uppsalalaan 8, The Netherlands
    Development 126:3473-83. 1999
    We have analysed the function of transforming growth factor beta (TGF-beta) in yolk sac development in mice by generating somatic chimaeras in which the extraembryonic mesoderm, which gives rise to the endothelial and haematopoietic cells ..
  55. pmc All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac
    Christopher T Lux
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202 5254, USA
    Blood 111:3435-8. 2008
    The relative contribution of yolk sac (YS)-derived cells to the circulating definitive hematopoietic progenitor cell (HPC) pool that seeds the fetal liver remains controversial due to the presence of systemic circulation and the onset of ..
  56. pmc Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 111:2636-9. 2008
    Hematopoiesis initiates within the yolk sac of mammalian embryos in overlapping primitive and definitive waves, each containing erythroid and megakaryocyte progenitors...
  57. ncbi Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver
    Parasakthy Kumaravelu
    Institute for Stem Cell Research, University of Edinburgh, West Main s Road, King s Buildings, UK
    Development 129:4891-9. 2002
    ..organ culture approach, we quantitatively assess the potential of the aorta-gonadmesonephros (AGM) region and the yolk sac to produce/expand definitive HSC/RUs during days 11-12 of embryogenesis...
  58. ncbi Nutrition of the human fetus during the first trimester--a review
    G J Burton
    Department of Anatomy, University of Cambridge, UK
    Placenta 22:S70-7. 2001
    ..within the fluid of the coelomic cavity, from which they may be transported to the fetus by the secondary yolk sac. Histiotrophic nutrition may be advantageous to the fetus during the first trimester as it provides nutrients ..
  59. ncbi The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: mapping multipotent hematopoietic cell fate in intraembryonic mesoderm
    M Tavian
    INSERM U506, Hopital Paul Brousse, 94807 Villejuif Cedex, France
    Immunity 15:487-95. 2001
    ..By contrast, hematopoietic cells arising in the third week yolk sac, as well as their progeny at later stages, were restricted to myelopoiesis and therefore are unlikely to ..
  60. ncbi Evidence that insulin is imprinted in the human yolk sac
    G E Moore
    Division of Paediatrics, Obstetrics and Gynaecology, Queen Charlotte s and Chelsea Hospital, Imperial College of Science, Technology and Medicine, London, UK
    Diabetes 50:199-203. 2001
    ..In mice, Ins2 is imprinted and paternally expressed in the yolk sac. In humans, evidence for the imprinting of INS is circumstantial, with occasional monoallelic expression in the ..
  61. pmc Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development
    Elias T Zambidis
    Division of Immunology and Hematopoiesis, Sidney Kimmel comprehensive Cancer Center at John Hokins, The John Hopkins School of Medicine, Baltimore, MD, USA
    Blood 106:860-70. 2005
    ..of semiadherent mesodermal-hematoendothelial (MHE) colonies that can generate endothelium and form organized, yolk sac-like structures that secondarily generate multipotent primitive hematopoietic stem progenitor cells (HSPCs), ..
  62. ncbi Embryonic development of the human hematopoietic system
    Manuela Tavian
    INSERM U506, Hopital Paul Brousse, Villejuif, France
    Int J Dev Biol 49:243-50. 2005
    Human hematopoiesis is initiated in the yolk sac during the third week of development...
  63. ncbi The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development
    A J Warren
    Medical Research Council Laboratory of Molecular Biology, Cambridge, England
    Cell 78:45-57. 1994
    ..The homozygous rbtn2 null mutation leads to failure of yolk sac erythropoiesis and embryonic lethality around E10.5...
  64. pmc Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development
    Caroline R McKeown
    The Scripps Research Institute, Department of Cell Biology, La Jolla, CA 92037, USA
    Circ Res 103:1241-8. 2008
    ..of mouse Tmod1 leads to defects in cardiac development, fragility of primitive erythroid cells, and an absence of yolk sac vasculogenesis, followed by embryonic lethality at embryonic day 9.5...
  65. pmc Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis
    Seiji Takashima
    Department of Internal Medicine and Therapeutics, Department of Nutrition and Physiological Chemistry, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 99:3657-62. 2002
    ..PECAM staining of yolk sac endothelial cells showed the absence of branching arteries and veins, the absence of a capillary bed, and the ..
  66. ncbi Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands
    Hiroo Ueno
    Institute of Stem Cell Biology and Regenerative Medicine and Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Dev Cell 11:519-33. 2006
    ..Here we applied this method to the analysis of embryonic yolk sac blood islands...
  67. ncbi Definitive erythropoiesis in chicken yolk sac
    Hiroki Nagai
    Laboratory for Early Embryogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
    Dev Dyn 237:3332-41. 2008
    ..wave of erythropoiesis in amniotic animals generates all primitive erythrocytes and takes place exclusively in yolk sac mesoderm...
  68. pmc Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
    Y Fujiwara
    Children s Hospital, Department of Pediatrics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 93:12355-8. 1996
    ..and fail to contribute to adult red blood cells in chimeric mice but did not clarify a role in embryonic (or yolk sac derived) erythroid cells...
  69. ncbi Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1
    Hoshimi Kanemura
    Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kusunoki cho, Chuo Ku, Japan
    Biochem Biophys Res Commun 387:754-9. 2009
    ..of VE-cadherin at cell-cell junctions were significantly impaired in the RA-GEF-1 knockout allantois and yolk sac. Rap1 activation as visualized by an activation-specific probe was also diminished by RA-GEF-1 knockout...
  70. ncbi Fluid compartments of the embryonic environment
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, UK
    Hum Reprod Update 6:268-78. 2000
    ..Its unique anatomical position has enabled us to study the protein metabolism of the early placenta and secondary yolk sac and to explore materno-embryonic transfer pathways...
  71. ncbi Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development
    Y Terasawa
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94110, USA
    J Lipid Res 40:1967-77. 1999
    In mice, the yolk sac appears to play a crucial role in nourishing the developing embryo, especially during embryonic days (E) 7;-10...
  72. ncbi From mesoderm to blood islands: patterns of key molecules during yolk sac erythropoiesis
    K Minko
    Institut d Embryologie Cellulaire et Moleculaire du CNRS et du College de France, 49 bis avenue de la Belle Gabrielle, 94736 Cedex, Nogent s Marne, France
    Gene Expr Patterns 3:261-72. 2003
    ..We have thoroughly analyzed the expression dynamics of some of these genes during yolk sac erythropoiesis in the chick embryo...
  73. ncbi Induction of yolk sac endoderm in GATA-4-deficient embryoid bodies by retinoic acid
    M Bielinska
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Mech Dev 65:43-54. 1997
    ..The presence of these yolk sac endoderm layers was confirmed by light microscopy and analysis of biochemical markers including alpha-fetoprotein,..
  74. ncbi Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis
    Paul D Kingsley
    Department of Pediatrics, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, NY 14642, USA
    Blood 104:19-25. 2004
    The enucleated definitive erythrocytes of mammals are unique in the animal kingdom. The observation that yolk sac-derived primitive erythroid cells in mammals circulate as nucleated cells has led to the conjecture that they are related to ..
  75. ncbi CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo
    Michael J Ferkowicz
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 130:4393-403. 2003
    ..0) yolk sac and high-level expression identifies essentially all E8.25 yolk sac definitive hematopoietic progenitors...
  76. pmc FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus
    Jonghan Kim
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 182:2583-9. 2009
    ..may give us a useful model to understand FcRn function in the human placenta, we have studied FcRn in the mouse yolk sac placenta in detail...
  77. ncbi Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice
    Rita L C Carvalho
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    J Cell Sci 120:4269-77. 2007
    ..Absence of either receptor in ECs resulted in vascular defects in the yolk sac, as seen in mice lacking receptors in all cells, causing embryonic lethality at embryonic day (E)10.5...
  78. ncbi Retinoid signaling regulates primitive (yolk sac) hematopoiesis
    Satish Ghatpande
    Department of Developmental and Molecular Biology, Chanin 501, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Blood 99:2379-86. 2002
    ..We propose that vitamin A-derived retinoids are required for normal yolk sac hematopoiesis and that an embryonic retinoid-BMP-GATA-2 signaling pathway controls progenitor cell survival ..
  79. ncbi Yolk sac nutrient composition and fat uptake in late-term embryos in eggs from young and old broiler breeder hens
    L Yadgary
    Department of Animal Science, Robert H Smith Faculty of Agriculture, Food and Environment, Hebrew University, Rehovot, Israel
    Poult Sci 89:2441-52. 2010
    ..Eggs were sampled at embryonic d 0 (fresh eggs), 13, 15, 17, 19, and 21 (hatch). Egg, embryo, yolk content, and yolk sac membrane were weighed, and the yolk sac (YS; i.e., yolk content + yolk sac membrane) composition was analyzed...
  80. ncbi Removal of vegetal yolk causes dorsal deficencies and impairs dorsal-inducing ability of the yolk cell in zebrafish
    T Mizuno
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, 464 8602, Japan
    Mech Dev 81:51-63. 1999
    ..These results suggested that the vegetal yolk cell mass contains the dorsal determinants, and that the dorsal-inducing ability of the yolk cell is dependent on the determinants...
  81. ncbi Flow regulates arterial-venous differentiation in the chick embryo yolk sac
    Ferdinand Le Noble
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Development 131:361-75. 2004
    Formation of the yolk sac vascular system and its connection to the embryonic circulation is crucial for embryo survival in both mammals and birds...
  82. ncbi Sinonasal teratocarcinosarcoma with yolk sac elements: a neoplasm of somatic or germ cell origin?
    Jaiyeola Thomas
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    Ann Diagn Pathol 15:135-9. 2011
    ..We report a case that exhibited foci of yolk sac elements with papillary structures and intracytoplasmic periodic acid-Schiff-positive, diastase-resistant, α-..
  83. ncbi Escape of the yolk sac: a hypothesis to explain the embryogenesis of gastroschisis
    R E Stevenson
    JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC, USA
    Clin Genet 75:326-33. 2009
    ..Our proposal is that the determining defect in gastroschisis is failure of the yolk sac and related vitelline structures to be incorporated into the umbilical stalk...
  84. ncbi [Microglia arise from extra-embryonic yolk sac primitive progenitors]
    Florent Ginhoux
    Singapore Immunology Network, Agency for Science, Technology and Research, Immunos, Biopolis, Singapour
    Med Sci (Paris) 27:719-24. 2011
    ..These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically-derived microglial progenitors for the treatment of various brain disorders...
  85. ncbi Role of endothelium in the control of mouse yolk sac stem cell differentiation
    R Auerbach
    Laboratory of Developmental Biology, University of Wisconsin, Madison 53706, USA
    Dev Comp Immunol 22:333-8. 1998
    Studies in our laboratory have shown that as early as day 8.5 of development, mouse yolk sac cells can generate T cells when placed in a thymic microenvironment...
  86. ncbi Critical time window of hedgehog-dependent angiogenesis in murine yolk sac
    Miki Nagase
    Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Microvasc Res 71:85-90. 2006
    Hedgehog family was reported to be involved in murine yolk sac angiogenesis...
  87. ncbi Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells
    S Matsuoka
    Department of Clinical Oncology, Institute of Medical Science, University of Tokyo, Japan
    Blood 98:6-12. 2001
    There is controversy as to whether murine definitive hematopoiesis originates from yolk sac (YS) or the intraembryonic region...
  88. ncbi Regulation of hematopoiesis by retinoid signaling
    Todd Evans
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Hematol 33:1055-61. 2005
    ..For example, novel insight has been gained regarding the function of retinoids in yolk sac hematovascular development, fetal erythropoiesis, T-cell homing, and hematopoietic stem and progenitor cell ..
  89. pmc Cell transplantation into immunodeficient chicken embryos. Reconstituting capacity of cells from the yolk sac at different stages of development and from the liver, thymus, bursa of Fabricius, spleen and bone marrow of 15-day embryos
    J Eskola
    Immunology 32:467-74. 1977
    Cyclophosphamide-treated 18-day-old chicken embryos were transplanted with histocompatible cells from the yolk sac at different stages of development and from the liver, thymus, bursa of Fabricius, spleen and bone marrow of 15-day-old-..
  90. ncbi Induction of avascular yolk sac due to reduction of basic fibroblast growth factor by retinoic acid in mice
    Y Yasuda
    Department of Anatomy 1st Division, Kinki University School of Medicine, Osaka, Japan
    Dev Biol 150:397-413. 1992
    ..Retinoic acid (RA) induced avascular yolk sac (AVY) of mouse embryos of dams given 60 mg/kg of RA orally on Day 8 of gestation and sacrificed 3 days later...
  91. ncbi The chicken yolk sac IgY receptor, a functional equivalent of the mammalian MHC-related Fc receptor, is a phospholipase A2 receptor homolog
    Anthony P West
    Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Immunity 20:601-10. 2004
    ..Maternal IgY, the avian counterpart of IgG, is transferred to embryos across yolk sac membranes. We affinity-purified the chicken yolk sac IgY receptor (FcRY) and sequenced its gene...
  92. pmc Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression
    Bin Wang
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 410:289-94. 2011
    ..Slc39a8(neo/neo) homozygotes exhibit dramatically decreased ZIP8 expression in embryo, fetus, and visceral yolk sac - in comparison to their littermate wild-type controls...
  93. ncbi Immortalization of yolk sac-derived precursor cells
    Wen Mei Yu
    Department of Hematopoiesis and the Flow Cytometry Facility, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855, USA
    Blood 100:3828-31. 2002
    Hematopoiesis initiates in the extraembryonic yolk sac. To isolate various types of precursor cells from this blood cell-forming tissue, yolk sac cells were immortalized by retroviral-mediated expression of the HOX11 homeobox-containing ..
  94. ncbi Erythropoietin-receptor expression and function during the initiation of murine yolk sac erythropoiesis
    J K McGann
    Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Exp Hematol 25:1149-57. 1997
    ..for definitive (fetal liver and bone marrow) erythropoiesis, the role of erythropoietin signaling in primitive (yolk sac) hematopoiesis has not been well defined...
  95. pmc Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality
    Mary L Holtz
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    BMC Dev Biol 8:65. 2008
    ..Resulting embryos were harvested at specific ages for observation of physical condition and analysis of genotype...
  96. ncbi A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice
    R V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100, USA
    J Lipid Res 37:347-60. 1996
    ..synthesis and secretion of triglyceride-rich lipoproteins by the intestine and liver, is highly expressed in the yolk sac visceral endoderm of mammals, although its function in this tissue has been hitherto unclear...
  97. ncbi B cell potential can be obtained from pre-circulatory yolk sac, but with low frequency
    Daisuke Sugiyama
    Division of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The Univeristy of Tokyo, 4 6 1 Shirokanedai, Tokyo, Japan
    Dev Biol 301:53-61. 2007
    ..Here, we successfully generated mouse chimeras by grafting yolk sac (YS) on YS of the host embryos before establishing circulation between YS and embryo proper and cultured the ..
  98. ncbi Blockade of c-Jun N-terminal kinase activation abrogates hyperglycemia-induced yolk sac vasculopathy in vitro
    Peixin Yang
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 198:321.e1-7. 2008
    Maternal hyperglycemia has an impact on both the function and morphology of the rodent visceral yolk sac; the objective of the present study was to determine whether hyperglycemia in vitro affects yolk sac vasculogenesis...
  99. ncbi From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis
    Ivan Maillard
    Division of Hematology Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
    Immunity 18:587-9. 2003
    ..Thus, different Notch receptors have specific and nonoverlapping functions that influence multiple hematopoietic lineages at various stages of development...
  100. ncbi Developmental expression of extracellular glutathione peroxidase suggests antioxidant roles in deciduum, visceral yolk sac, and skin
    P D Kingsley
    Department of Pediatrics and Cancer Center, University of Rochester Medical Center, New York 14642, USA
    Mol Reprod Dev 49:343-55. 1998
    ..At E9.5, the major sites of expression were the yolk sac endoderm and heart musculature. By E16...
  101. ncbi Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells
    Weiming Li
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stem Cells Dev 14:44-54. 2005
    ..CD34, and Flk1 in some intraluminal round cells that appeared to arise from flattened endothelial cells lining yolk sac capillary vessels...

Research Grants65

  1. Genetic and Epigenetic Regulation of Hematopoiesis.
    Shireen Saleque; Fiscal Year: 2013
    ..for the generation of the erythroid and megakaryocytic lineages and for proper differentiation of primitive (yolk sac derived) erythroid cells...
  2. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013
    ..During vertebrate development, the site of hematopoieis moves from the yolk sac of the embryo to the embryo dorsal aorta to the fetal liver, then to the fetal spleen and finally to the bone ..
  3. Morphogenesis of mammalian gut endoderm
    Anna Katerina Hadjantonakis; Fiscal Year: 2012
    ..with the epiblast to establish the body axes, they contribute solely to extraembryonic structures, such as the yolk sac and placenta...
  4. The role of b-carotene in maternal-fetal nutrition
    Loredana Quadro; Fiscal Year: 2013
    ..e., placenta and yolk sac)...
  5. Human iPS/ES Cell-Based Models for Predictive Neural Toxicity and Teratogenicity
    JAMES ALEXANDER THOMSON; Fiscal Year: 2013
    ..from diverse embryological origins, including the neural plate (neurons, oligodendrocytes, and astrocytes), yolk sac myeloid progenitors (microglia), migratory mesodermal angioblasts (endothelial cells), and neural crest (vascular ..
  6. FcgRIIb protects fetus from allograft rejection
    Clark L Anderson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Whether Fc3RIIb (RIIb) of the mouse yolk sac (YS) protects the conceptus from IgG-mediated allograft rejection, the focus of this application, has evolved from our long term interest in how the human ..
  7. RIPK-dependent necrosis in development and cancer
    Douglas R Green; Fiscal Year: 2013
    ..5, associated with a defect in yolk sac vascularization...
  8. Effects of developmental stage and of KLF2 on mouse erythroid genetic profiles
    Joyce A Lloyd; Fiscal Year: 2011
    ..has been established using the rarest type of erythroid cells, purified from mouse embryonic day 9 (E9) yolk sac tissue sections...
  9. Mechanisms of Vitamin E Function Studied in Zebrafish
    Maret G Traber; Fiscal Year: 2010
    ..TTP expression in the zebrafish embryo suggests that during development -TTP directs -tocopherol from the yolk sac to specific sites in the developing embryo where it is especially required...
  10. A pilot study of DNA methylation in pediatric germ cell tumors
    Jenny N Poynter; Fiscal Year: 2010
    ..of genes with altered promoter hypermethylation in DNA extracted from 58 pediatric GCTs, including germinomas, yolk sac tumors, teratomas and mixed germ cell tumors, overall and by histologic type...
  11. Lymphopoietic development in the extra-embryonic yolk sac
    Mervin C Yoder; Fiscal Year: 2013
    ..present work is to determine the mechanisms that permit the emergence of B lymphoid cells in the extraembryonic yolk sac and the para aortic splanchnopleura (P-Sp) and facilitate the homing of these cells into the peritoneal cavity...
  12. Signaling pathways and expansion of hematopoietic stem cells in zebrafish
    JILL L DE JONG; Fiscal Year: 2010
    ..Chemicals will then be tested on mouse ES cells and yolk sac blood island cultures to examine expansion of multipotent progenitor (CFU-GEMM) colonies...
  13. Signaling Mechanisms of Heterotrimeric G proteins
    Xin Yun Huang; Fiscal Year: 2012
    ..Ga13 -/- mice died at E9.5. Yet the molecular basis for this embryonic lethality is not clear. Since the yolk sac of Ga13 -/- mouse embryos (at E9...
  14. THE ROLE OF IL-34 IN THE BIOLOGY OF LANGERHANS CELLS
    Marco Colonna; Fiscal Year: 2013
    ..shown that LCs are unique among myeloid cells in their development: they arise from embryonic progenitors of the yolk sac and the fetal liver that populate the developing skin before birth...
  15. HEMATOPOIETIC COMMITMENT: MOLECULAR MECHANISMS
    Kyunghee Choi; Fiscal Year: 2013
    ..In later stages yolk sac, fetal liver or bone marrow, ER71 expression is greatly reduced, but other Ets factor expression is prominent...
  16. Erythroid Development in the Mammalian Embryo
    Margaret H Baron; Fiscal Year: 2011
    ..Large, nucleated EryP arise within the blood islands of the yolk sac beginning ~E7.5 and begin to circulate around E9...
  17. Detection of BMP Signaling In Pre-Implantation Mouse Embryos
    Nabora Soledad Reyes de Mochel; Fiscal Year: 2013
    ..embryo gives rise to the trophectoderm (TE), the precursor for extraembryonic structures such as the placenta and yolk sac, and the inner cell mass (ICM), which becomes the embryo proper...
  18. SWI/SNF & Yolk Sac Development
    Terry Magnuson; Fiscal Year: 2010
    The mammalian yolk sac provides an important nutritive role in the early postimplantatlon embryo...
  19. Induction and Specification of Hematopoietic Mesoderm
    Margaret H Baron; Fiscal Year: 2013
    ..allowed us to define global gene expression profiles during six distinct stages of development, from progenitor (yolk sac) through circulating and fetal liver stages...
  20. INITIATION OF MAMMALIAN EMBRYONIC HEMATOPOIESIS
    James Palis; Fiscal Year: 2012
    ..We have defined the appearance of two overlapping waves of hematopoietic potential in the yolk sac prior to the emergence of hematopoietic stem cells...
  21. The human placenta as a novel source of hematopoietic stem cells
    Alicia Barcena; Fiscal Year: 2009
    ..phase of angio-hematopoiesis occurs around 16 days of development in the extra-embryonic niche provided by the yolk sac. The hematopoietic output of the yolk sac is gradually replaced by sequential intra-embryonic sites...
  22. INTESTINAL & PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 2000
    ..Late in gestation, the same receptor appears to transport IgG across the fetal yolk sac in these species...
  23. MOLECULAR CONTROL OF ANGIOGENESIS
    Victoria L Bautch; Fiscal Year: 2013
    ..using stem cell-derived blood vessels, and we will complement these experiments with in vivo experiments in the yolk sac and the retina...
  24. ENDOTHELIUM REGULATION OF STEM CELL HOMING/PROLIFERATION
    Shahin Rafii; Fiscal Year: 2000
    ..Within the hematopoietic micro-environment, whether it is embryonic yolk sac, fetal liver, or adult bone marrow, microvascular endothelium not only provides cellular contact and secrete ..
  25. ETS-1 AND ELF-1 AND MEGAKARYOPOIESIS
    Kevin Barton; Fiscal Year: 2001
    ..on megakaryocyte development, gene expression, platelet production and function extensively analyzed in the yolk sac, fetal liver, and adult bone marrow...
  26. MOLECULAR STUDIES OF X-LINKED CHONDRODYSPLASIA PUNCTATA
    Gail Herman; Fiscal Year: 2009
    ..with the male lethality by characterizing defects for the most severe Bpalli Nsdhl allele and those in the yolk sac vessels and in cultured allantois explants from affected Nsdhf male embryos. 2...
  27. Study of Ferroportin 1 in mammalian iron homeostasis
    Adriana Donovan; Fiscal Year: 2006
    ..exporter, and is important for normal development in zebrafish, where it is needed for transfer of iron from the yolk sac to developing erythrocytes. In contrast, the role of Fpn1 in mammals has not been established...
  28. 2003 TERATOLOGY SOCIETY MEETINGS: TRAVEL FOR STUDENTS
    Thomas Knudsen; Fiscal Year: 2003
    ..during pregnancy (Public Affairs Workshop); teratogen update on endocrine-active compounds; and the rat inverted yolk sac as a biological model for risk analysis...
  29. DEVELOPMENT OF THE SECRETORY IMMUNE SYSTEM
    Albert Jones; Fiscal Year: 1991
    ..The surface characteristics of adult lymphocytes will be compared to cells which home to the liver from the yolk sac during fetal development...
  30. REGULATION OF ALPHA-FETOPROTEIN GENE EXPRESSION
    Shirley Tilghman; Fiscal Year: 1993
    ..fetus is alpha-fetoprotein (AFP), which is synthesized in the embryonic liver and visceral endoderm of the yolk sac. After birth, the rate of synthesis of AFP in liver decreases drastically to levels that are barely detectable in ..
  31. ONTOGENY OF HEMOGLOBIN IN MAMMALIAN ERYTHROID CELLS
    THALIA BOUSSIOS; Fiscal Year: 1990
    ..With these aims as introductory probes into mechanisms, we anticipate that the ability to exercise tight experimental control in culture will facilitate useful interpretation of results...
  32. DYNAMICS OF PROTEIN METABOLISM IN RAT CONCEPTUS
    DAVID BECKMAN; Fiscal Year: 1990
    ..for protein synthesis by the embryo during organogenesis stem from serum proteins degraded by the visceral yolk sac (VYS) rather than from free amino acids have focused our attention on aspects of fetal nutrition and the changing ..
  33. MARGINAL BAND SYSTEM OF ERYTHROCYTES
    William Cohen; Fiscal Year: 1980
    ....
  34. Role of TIMPs in Hematopoietic Stem Cell Biology
    KEVIN BUNTING; Fiscal Year: 2006
    ..development, primitive HSCs must migrate appropriately from the sites of the aorta-gonad-mesonephros (AGM) and yolk sac regions, to mature and expand as definitive HSCs in the fetal liver, and finally move to the BM in the newborn...
  35. Molecular Mechanisms of Tissue Stem Cell Plasticity
    Stuart Orkin; Fiscal Year: 2004
    ..a hematopoietic committed stem cell population from in vitro differentiated embryonic stem (ES) cells and mouse yolk sac, and also the influence of loss of hematopoietic or muscle regulatory factors on observed plasticity...
  36. FUNCTIONAL ANALYSIS OF VEFZ1, A NOVEL ENDOTHELIAL MARKER
    Heidi Stuhlmann; Fiscal Year: 2003
    ..specifically in vascular endothelial cells, the cells that line the blood vessels, and in their precursors in the yolk sac blood islands...
  37. Identification and Characterization of the Hemangioblast
    Gordon Keller; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): The concept that the hematopoietic and endothelial lineages of the early yolk sac arise from a common progenitor, the hemangioblast, was put forth almost a century ago...
  38. Modeling Developmental Hematopoiesis with Embryonic Stem
    George Daley; Fiscal Year: 2005
    ..Blood formation from murine ES cells in vitro resembles the yolk sac stage of embryonic development, and previous data have shown that yolk sac progenitors fail to engraft directly ..
  39. Imaging fluid forces in mouse cardiovascular development
    Mary Dickinson; Fiscal Year: 2007
    ..Here we will test the hypothesis that mechano-sensory signals are necessary for proper development of the yolk sac vasculature using three sets of in vivo, multispectral imaging experiments: First, we will study how the vascular ..
  40. Characterization and Molecular Regulation of Embryonic Hemogenic Endothelium
    TIFFANY SILLS; Fiscal Year: 2009
    ..our lab has defined a population of cKit+ cells that reside within the vascular endothelium within the developing yolk sac, and when sorted by cKit+ CD45- cell surface marker expression give rise to hematopoietic colonies when cultured ..
  41. ADHESION ANALYSIS OF CYCLING STEM CELLS THROUGH ONTOGENY
    EDWARD SROUR; Fiscal Year: 2002
    ..We believe that during ontogeny, progression of hematopoiesis from the yolk sac to the liver and finally to the BM is governed by the expression of adhesion molecules and counter-receptor sets ..
  42. FUNCTIONS OF MEF2C IN VASCULAR DEVELOPMENT
    John Schwarz; Fiscal Year: 2002
    ..The yolk sac vasculature forms a capillary network but never reorganizes into the normal branching pattern of variably sized ..
  43. DEVELOPMENTAL & NEOPLASTIC GENE EXPRESSION IN THE LIVER
    Joseph Locker; Fiscal Year: 1993
    ..experimental system for the study of developmental gene controls, is expressed at high levels in fetal liver and yolk sac, but silenced after birth...
  44. Cellular and Molecular Mechanisms of Vascular Remodeling
    Josephine Enciso; Fiscal Year: 2009
    ..Recent data from the Hirschi laboratory have demonstrated that defects in yolk sac remodeling can result from dysregulation of cell cycle control and lack of secreted growth factors from the yolk ..
  45. FOS ONCOGENE IN DEVELOPMENT
    Eileen Adamson; Fiscal Year: 1993
    ..Extraembryonic tissues express the highest levels (placenta, amnion, visceral yolk sac, etc.), but fetal liver, bone marrow, and skin also express c-fos constitutively at lower levels...
  46. MEGAKARYOCYTE AND PLATELET PROTEOGLYCANS
    BARBARA SCHICK; Fiscal Year: 2000
    ..This laboratory has recently found that the molecule is also expressed in human endothelial cells, in murine yolk sac, and in embryonic stem cells...
  47. Hematopoietic Stem Cells from Pluripotent Embryonic Stem Cells
    George Daley; Fiscal Year: 2009
    ..the ES-HSC derives from the primitive hemangioblast progenitor-the in vitro equivalent of extra-embryonic or yolk sac mesoderm-or from the equivalent of intra-embryonic lateral plate mesoderm, which would validate our hypothesis...
  48. AFP GENE EXPRESSION AND CARCINOGENESIS
    Stewart Sell; Fiscal Year: 1990
    The rat gene encoding the serum protein alphafetoprotein (AFP) is active in the fetal liver and yolk sac, but is repressed after birth...
  49. Defining Mesodermal Origins of Hematopoietic Stem Cells
    Paul Gadue; Fiscal Year: 2006
    ..It is now generally accepted that the extra-embryonic yolk sac and the paraaortic splanchnopleura / aorta-gonad-mesonephros regions of the embryo represent independent sites of ..
  50. MECHANISM OF CELL-SPECIFIC METALLOTHIONEIN TRANSCRIPTION
    PATRICK DANIELS; Fiscal Year: 2003
    ..Our long-term objective is to elucidate the mechanisms that regulate MT expression in the visceral yolk sac and maternal decidual cells...
  51. The Role of the PBAF-specific subunit BAF200 in blood vessel formation
    Nicholas Osborne; Fiscal Year: 2009
    ..expression is specifically controlled by complexes containing BAF200, using complementary approaches in the mouse yolk sac and in an endothelial cell culture model...
  52. The Role of ARNT in Vascular and Cardiac Development
    DIANA RAMIREZ BERGERON; Fiscal Year: 2007
    ..5 days postcoitum (dpc) with yolk sac, placental, cardiac, and vascular defects...
  53. Functional Analysis of Hematopoietic Stem Cell Origin
    David Archer; Fiscal Year: 2002
    ..In the mouse embryo, primitive hematopoietic progenitors arise in the yolk sac during gastrulation (E7.0-E8.5). While definitive blood cells differentiate in the fetal liver beginning at E.9...
  54. Molecular Regulation of Vascular Development
    Heidi Stuhlmann; Fiscal Year: 2006
    ..during embryogenesis is restricted to vascular endothelial cells and their mesodermal precursors in the yolk sac blood islands...
  55. EPS: A Novel Hematopoietic Transcription Factor
    John Crispino; Fiscal Year: 2006
    ..EPS is expressed at the onset of yolk sac erythropoiesis in the developing mouse embryo, and enriched in the fetal liver, the site of definitive ..
  56. YOLK SAC STEM CELL DIFFERENTIATION IN VITRO AND VIVO
    Robert Auerbach; Fiscal Year: 2000
    ..Adapted from the investigator's abstract): The hypothesis of this application is that in vitro expanded yolk sac hematopoietic stem cells can successfully engraft in histoincompatible hosts in which they then differentiate, ..
  57. Methods for Modulating Hemato-Vascular Development
    MARGARET BARON; Fiscal Year: 2007
    ..Within the developing vascular network of the yolk sac as well as in certain intra embryonic regions, endothelial and hematopoietic cells arise in close spatial and ..
  58. Dietary Cysteine:Conceptal Response to Oxidative Stress
    Craig Harris; Fiscal Year: 2002
    ..The investigators hypothesize that the availability of free cysteine in the embryo and visceral yolk sac of the post-implantation embryo determines the extent to which the embryo is able to maintain adequate ..
  59. Initiation of Mammalian Yolk Sac Hematopoiesis
    James Palis; Fiscal Year: 2006
    ..While definitive hematopoiesis in the fetus and adult is multilineage, hematopoiesis in the yolk sac has been widely considered to consist exclusively of the primitive erythroid lineage that generates nucleated red ..
  60. ENDOTHELIAL CELL ROLE IN YOLK SAC STEM CELL DEVELOPMENT
    Mervin Yoder; Fiscal Year: 2008
    The overall goal of our work is to elucidate the molecular mechanisms of yolk sac blood island organogenesis...
  61. Cord Blood Stem Cell Expansion Ex Vivo With Endothelial Progenitor Cells
    Mervin Yoder; Fiscal Year: 2005
    ..abstract_text> ..
  62. Ontogeny of erythroid lineage differentiation
    James Palis; Fiscal Year: 2010
    ..Stoeckert (U. Penn). The ability to compare similar stages of primitive red cells from the yolk sac and definitive red cells from the fetal liver and adult bone marrow gives us the unique opportunity to identify ..
  63. Embryonic hematopoietic stem cell origin and ontogeny
    James Palis; Fiscal Year: 2004
    ..During development, primitive eiythroblasts arise in the yolk sac while definitive blood cells subsequently differentiate in the fetal liver and bone marrow...
  64. Environmental Toxicology Using Transgenic Models
    Glen Andrews; Fiscal Year: 2005
    ..Functions of MTF-l during development will be examined in Zebrafish using morpholino antisense oligonucleotides, whole mount in situ hybridization and morphometric analyses of developing embryos. ..
  65. Molecular Biology of Mammalian Zinc Homeostasis
    Glen Andrews; Fiscal Year: 2006
    ..The co-I., Dr. Eide is an expert and leader in the field of ZIP transport function, and our collaborator, Dr. Palmiter is an expert in gene targeting in mice. ..