Genomes and Genes
Summary: The embryo of species other than mammals. For the chicken, use the specific CHICK EMBRYO.
Publications339 found, 100 shown here
- p53 activation by knockdown technologiesMara E Robu
University of Minnesota, Minneapolis, Minnesota, United States of America
PLoS Genet 3:e78. 2007..p53 inhibition could potentially be applicable to other systems to suppress off-target effects caused by other knockdown technologies...
- Analysis of genetic mosaics in developing and adult Drosophila tissuesT Xu
Howard Hughes Medical Institute, University of California, Berkeley 94720
Development 117:1223-37. 1993....
- MicroRNA expression in zebrafish embryonic developmentErno Wienholds
Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands
Science 309:310-1. 2005....
- High-resolution in situ hybridization to whole-mount zebrafish embryosChristine Thisse
Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 800732, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
Nat Protoc 3:59-69. 2008..The whole procedure takes only 3 days and, because ISH conditions are the same for each probe tested, allows high throughput analysis of zebrafish gene expression during embryogenesis...
- Controlling morpholino experiments: don't stop making antisenseJudith S Eisen
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
Development 135:1735-43. 2008..We also discuss how the use of morpholinos can lead to misleading results, including off-target effects, and we suggest controls that will allow researchers to interpret morpholino experiments correctly...
- Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafishD Yelon
Programs in Human Genetics and Developmental Biology, University of California, San Francisco, San Francisco, California, 94143 0448, USA
Dev Biol 214:23-37. 1999..Altogether, these data suggest new models for the mechanisms that regulate the formation of a patterned heart tube and provide an important framework for future analyses of zebrafish mutants with defects in this process...
- Multiple forces contribute to cell sheet morphogenesis for dorsal closure in DrosophilaD P Kiehart
Department of Cell Biology, Cell and Molecular Biology Program, University Program in Genetics and the Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina 27710 3709, USA
J Cell Biol 149:471-90. 2000..Moreover, our observations demonstrate that wound healing in this insect epidermal system parallel wound healing in vertebrate tissues in situ and vertebrate cells in culture (for review see Kiehart, D.P. 1999. Curr. Biol. 9:R602-R605)...
- Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryoEdwin Munro
Center for Cell Dynamics, Friday Harbor, WA 98250, USA
Dev Cell 7:413-24. 2004..Similar actomyosin flows accompany the establishment of PAR asymmetries that form after the one-cell stage, suggesting that actomyosin-mediated cortical flows have a general role in PAR asymmetry...
- Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformationLuika A Timmerman
University of California Comprehensive Cancer Center, San Francisco, California 94115, USA
Genes Dev 18:99-115. 2004..Notch is expressed in embryonic regions where EMT occurs, suggesting an intimate and fundamental role for Notch, which may be reactivated during tumor metastasis...
- Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulationC P Heisenberg
Department of Anatomy and Developmental Biology, University College, London, UK
Nature 405:76-81. 2000..Our results provide genetic and experimental evidence that Wnt activity in lateral tissues has a crucial role in driving the convergent extension movements underlying vertebrate gastrulation...
- Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cellsM S Rhyu
Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
Cell 76:477-91. 1994..Thus, numb functions to determine the fates of the secondary precursors; the differential distribution of numb as the SOP divides generates an asymmetric division in which the daughter cells acquire distinct identities...
- Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migrationBrian Stramer
Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
J Cell Biol 168:567-73. 2005..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues...
- Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fateAlex S Flynt
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
Nat Genet 39:259-63. 2007..We show that su(fu) mRNA, encoding a negative regulator of Hedgehog signaling, is targeted by miR-214. Through regulation of su(fu), miR-214 enables precise specification of muscle cell types by sharpening cellular responses to Hedgehog...
- sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiationNathan D Lawson
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
Dev Cell 3:127-36. 2002..These studies reveal a complex signaling cascade responsible for establishing arterial cell fate and suggest differential effects of Vegf on developing endothelial cells...
- Cellular and molecular analyses of vascular tube and lumen formation in zebrafishSuk Won Jin
Department of Biochemistry and Biophysics and Cardiovascular Research Institute, Program in Developmental Biology, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
Development 132:5199-209. 2005..These studies provide the tools and a cellular framework for the investigation of mutations affecting vasculogenesis in zebrafish...
- Patterned gene expression directs bipolar planar polarity in DrosophilaJennifer A Zallen
Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA
Dev Cell 6:343-55. 2004..These results indicate that spatial patterns of gene expression coordinate planar polarity across a multicellular population through the localized distribution of proteins required for cell movement...
- Vertebrate Smoothened functions at the primary ciliumKevin C Corbit
Developmental and Stem Cell Biology Program, University of California, San Francisco, California 94143, USA
Nature 437:1018-21. 2005..Thus, Hh-dependent translocation to cilia is essential for Smo activity, suggesting that Smo acts at the primary cilium...
- Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate developmentGregory Golling
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nat Genet 31:135-40. 2002....
- Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafishG J Lieschke
Ludwig Institute for Cancer Research, The Royal Melbourne Hospital, Parkville, Victoria, Australia
Blood 98:3087-96. 2001..These observations will facilitate the application of this genetically tractable organism to the study of myelopoiesis...
- Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafishS E Stachel
Department of Human Genetics, University of Utah, Salt Lake City 84112
Development 117:1261-74. 1993..Our results demonstrate that the zebrafish dorsal axis is signaled by a pathway initiated in the cleavage-stage embryo. Furthermore, they provide novel insights into anterior morphogenesis...
- Control of chemokine-guided cell migration by ligand sequestrationBijan Boldajipour
Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
Cell 132:463-73. 2008....
- Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafishJun Chen
Laboratory of Functional Genomics, Laboratory of Molecular and Developmental Immunology, Laboratory of Control of p53 Pathway, Institute of Molecular and Cell Biology, Proteos, Singapore 138673
Genes Dev 19:2900-11. 2005....
- Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryoP GONCZY
European Molecular Biology Laboratory, Heidelberg, D 69117 Germany
J Cell Biol 147:135-50. 1999..In conjunction with our observation of cytoplasmic dynein distribution at the periphery of nuclei, these results lead us to propose a mechanism in which cytoplasmic dynein anchored on the nucleus drives centrosome separation...
- Guidance of primordial germ cell migration by the chemokine SDF-1Maria Doitsidou
Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
Cell 111:647-59. 2002..Finally, we show that the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs...
- Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradientFilippo Del Bene
Department of Physiology, Programs in Neuroscience, Genetics, and Developmental Biology, University of California San Francisco, San Francisco, CA 94158 2722, USA
Cell 134:1055-65. 2008..Our data indicate that the function of INM is to balance the exposure of progenitor nuclei to neurogenic versus proliferative signals...
- Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signalingUlrike Langheinrich
Exelixis Deutschland GmbH, Spemannstrasse 35, D 72076 Tubingen, Germany
Curr Biol 12:2023-8. 2002..We conclude that zebrafish represents a promising model organism for future compound-based and genetic screens and believe that it will help to identify and characterize new anticancer drugs and new targets for cancer treatment...
- Sequential protein recruitment in C. elegans centriole formationMarie Delattre
Swiss Institute for Experimental Cancer Research, School of Life Sciences ISREC, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
Curr Biol 16:1844-9. 2006..Several of these proteins have homologs in other metazoans, and we expect the assembly pathway that stems from our work to be conserved...
- Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryoT Lecuit
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
J Cell Biol 150:849-60. 2000..We thus identify a tightly regulated scheme of polarized membrane insertion during cellularization. We propose that such a mechanism could participate in the progressive emergence of apical-basal polarity...
- Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functionsXin Zeng
The F M Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
Development 135:367-75. 2008..We discuss the dual roles of the axin-Gsk3 complex and signal amplification by Lrp6-axin interaction during Wnt/beta-catenin signaling...
- The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brainAndrea Mahr
Max Planck Institut fur Entwicklungsbiologie, Abt III Genetik, Spemannstr 35, 72076 Tubingen, Germany
Gene Expr Patterns 6:299-309. 2006..Given that vesicular glutamate transporters are essential for the uptake of the neurotransmitter glutamate into synaptic vesicles these tools provide a means to test gene function in these functionally important neurons...
- Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing moleculesShuizi Rachel Yu
Developmental Genetics, Biotechnology Center, TUD, Tatzberg 47 49, 01307 Dresden, Germany
Nature 461:533-6. 2009..Our results demonstrate that a freely diffusing morphogen can set up concentration gradients in a complex multicellular tissue by a simple source-sink mechanism...
- Drosophila melanogaster embryonic haemocytes: masters of multitaskingWill Wood
Department of Biology and Biochemistry, University of Bath, BA2 7AY, UK
Nat Rev Mol Cell Biol 8:542-51. 2007..Instead, throughout development, embryonic haemocytes are occupied with other tasks: they undergo complex migrations and carry out several non-immune functions that are crucial for successful embryogenesis...
- A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in ZebrafishSaskia Houwing
Hubrecht Laboratory, Uppsalalaan 8, Utrecht, Netherlands
Cell 129:69-82. 2007..Furthermore, we show that piRNAs are Dicer independent and that their 3' end likely carries a 2'O-Methyl modification...
- The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafishLucy J Patterson
Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford, United Kingdom
Blood 109:2389-98. 2007..Thus, expression of these critical regulators is dependent on continued expression of upstream regulators, which may include cell-extrinsic signals...
- Proteomics of early zebrafish embryosVinzenz Link
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauer Str 108, 01307 Dresden, Germany
BMC Dev Biol 6:1. 2006..While genetic methods are readily available in zebrafish, protocols for two dimensional (2D) gel electrophoresis and proteomics have yet to be developed...
- The cytoskeleton and morphogenesis of the early Drosophila embryoW Sullivan
Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz 95064, USA
Curr Opin Cell Biol 7:18-22. 1995....
- RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryoJulia Zeitlinger
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Genet 39:1512-6. 2007..We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development...
- FGF-dependent mechanosensory organ patterning in zebrafishAlex Nechiporuk
University of Washington, School of Medicine, Department of Biological Structure, Seattle, WA 98195 7420, USA
Science 320:1774-7. 2008..This previously unrecognized mechanism may be applicable to understanding segmentation and morphogenesis in other organ systems...
- The TAGteam DNA motif controls the timing of Drosophila pre-blastoderm transcriptionJohn R ten Bosch
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3204, USA
Development 133:1967-77. 2006....
- Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infectionsAstrid M van der Sar
Department of Medical Microbiology, Vrije Universiteit Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Cell Microbiol 5:601-11. 2003..In conclusion, the zebrafish embryo model allows for rapid, non-invasive and real time analysis of bacterial infections in a vertebrate host...
- Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryosAnne Royou
CNRS Centre de Génétique Moléculaire, 91198 Gif sur Yvette, France
Mol Biol Cell 15:838-50. 2004..We suggest that cellularization can be divided into two distinct processes: furrow ingression, driven by microtubule mediated vesicle delivery, and basal closure, which is mediated by actin/myosin based constriction...
- Transgenesis and gene trap methods in zebrafish by using the Tol2 transposable elementKoichi Kawakami
Division of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
Methods Cell Biol 77:201-22. 2004
- Zebrafish vasa RNA but not its protein is a component of the germ plasm and segregates asymmetrically before germline specificationH Knaut
Max Planck Institut für Entwicklungsbiologie Abteilung Genetik, 72076 Tubingen, Germany
J Cell Biol 149:875-88. 2000..Triggered by maternal signals, the pattern of germ plasm segregation changes, which results in the expression of primordial germ cell-specific genes such as vasa and, consequently, in germline fate commitment...
- A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in XenopusC Kiecker
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Development 128:4189-201. 2001..Our results indicate that an activity gradient of Wnt/beta-catenin signalling acts as transforming morphogen to pattern the Xenopus central nervous system...
- The PDGF/VEGF receptor controls blood cell survival in DrosophilaKatja Brückner
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Dev Cell 7:73-84. 2004..This function of PVR shows striking conservation with mammalian hematopoiesis and establishes Drosophila as a model to study hematopoietic cell survival in development and disease...
- Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAsAntonio J Giraldez
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Science 312:75-9. 2006..We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis...
- Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogasterWill Wood
Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
J Cell Biol 173:405-16. 2006....
- Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesisS Krauss
Department of Microbiology, University of Tromsø, Norway
Development 113:1193-206. 1991..The characteristic expression pattern of pax[zf-b] in the neural tube suggests an involvement of this gene in the regionalization of the midbrain as well as in the specification of neuronal cell fates at early embryonic stages...
- Convergent extension: the molecular control of polarized cell movement during embryonic developmentJohn B Wallingford
Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, 94720, USA
Dev Cell 2:695-706. 2002..Focusing on frogs and fish, we review the different cellular mechanisms and the well-conserved signaling pathways that underlie this process...
- Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordiumVirginie Lecaudey
European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
Development 135:2695-705. 2008..Furthermore, this work uncovers a surprising link between internal tissue organization and collective migration...
- Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegansY Tabuse
Fundamental Research Laboratories, NEC Corporation, Tsukuba, Ibaraki 305, Japan
Development 125:3607-14. 1998..We conclude that PKC-3 plays an indispensable role in establishing embryonic polarity through interaction with PAR-3...
- An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerioD M Parichy
Department of Genetics, Washington University Medical School, St Louis, MO 63110, USA
Development 127:3031-44. 2000..These findings reveal an unexpected role for fms in pigment pattern development and demonstrate that parallel neural crest-derived pigment cell populations depend on the activities of two essentially paralogous genes, kit and fms...
- Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathyJames J Dowling
Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan, USA
PLoS Genet 5:e1000372. 2009..Based on our findings, we speculate that congenital myopathies, usually considered entities with similar clinical features but very disparate pathomechanisms, may at their root be disorders of calcium homeostasis...
- MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosisM Srayko
Department of Biochemistry, Development Research Group, University of Calgary, Calgary, Alberta, T2N 4N1 Canada
Genes Dev 14:1072-84. 2000..These data lead us to conclude that MEI-1/MEI-2 microtubule-severing activity is required for meiotic spindle organization in C. elegans...
- Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8Claudia Couwenbergs
Institute of Biochemistry, ETH Eidgenössische Technische Hochschule Hoenggerberg, 8093 Zurich, Switzerland
Curr Biol 14:1871-6. 2004..We suggest that RIC-8 directly modulates Galpha activity and that Galpha-GTP is the signaling molecule regulating spindle positioning in the early embryo...
- Unique and conserved aspects of gut development in zebrafishKenneth N Wallace
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Dev Biol 255:12-29. 2003....
- CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivoAlexander Y Konev
Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Science 317:1087-90. 2007..Furthermore, our results point to the general requirement of adenosine triphosphate (ATP)-utilizing motor proteins for histone deposition in vivo...
- CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryosJayne M Squirrell
Laboratory for Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
Mol Biol Cell 17:336-44. 2006..Thus, CAR-1, a protein likely to be associated with RNA metabolism, plays an essential role in the late stage of cytokinesis, suggesting a novel link between RNA, membrane trafficking and cytokinesis in the C. elegans embryo...
- Trafficking through Rab11 endosomes is required for cellularization during Drosophila embryogenesisAnne Pelissier
Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, France
Curr Biol 13:1848-57. 2003..In Drosophila, the process is specialized and called cellularization. The trafficking pathways that underlie this process and that are responsible for the mobilization of membrane pools, however, remain poorly understood...
- The anterior determinant bicoid of Drosophila is a derived Hox class 3 geneM Stauber
Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Am Fassberg 11, D 37077 Gottingen, Germany
Proc Natl Acad Sci U S A 96:3786-9. 1999....
- Expression of a type II collagen gene in the zebrafish embryonic axisY L Yan
Institute of Neuroscience, University of Oregon, Eugene 97403, USA
Dev Dyn 203:363-76. 1995....
- Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblastsA Wodarz
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
J Cell Biol 150:1361-74. 2000..This study is the first functional analysis of an atypical protein kinase C isoform using a loss-of-function allele in a genetically tractable organism...
- Zebrafish pea3 and erm are general targets of FGF8 signalingH Roehl
Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35 III, D 72076, Tubingen, Germany
Curr Biol 11:503-7. 2001..To test whether this differential expression is established by FGF8, we have induced FGF8 ectopically and show that it is sufficient to recapitulate the endogenous nested expression pattern of pea3 and erm...
- Mechanisms of asymmetric cell division: flies and worms pave the wayPIERRE GONCZY
Swiss Institute for Experimental Cancer Research ISREC, Swiss Federal Institute of Technology EPFL, School of Life Sciences, Lausanne, Switzerland
Nat Rev Mol Cell Biol 9:355-66. 2008..Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals...
- Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integritySaeko Takada
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Cell 113:87-99. 2003..DmChk2 is therefore essential for a "mitotic catastrophe" signal that disrupts centrosome function in response to genotoxic stress and ensures that mutant and aneuploid nuclei are eliminated from the embryonic precursor pool...
- The Drosophila gastrulation gene concertina encodes a G alpha-like proteinS Parks
Department of Molecular Biology, Princeton University, New Jersey 08540
Cell 64:447-58. 1991..The phenotype of embryos from homozygous cta mothers suggests that the cta gene plays a role in a signal transduction pathway used during gastrulation...
- Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eyeJiwoon Lee
Section of Molecular Cell and Developmental Biology and Institute for Cell and Molecular Biology, USA
Dev Biol 319:10-22. 2008....
- Organization and function of the blood-brain barrier in DrosophilaTobias Stork
Institut fur Neurobiologie, Universitat Munster, D 48149 Münster Germany
J Neurosci 28:587-97. 2008....
- Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectodermTetsuhiro Kudoh
Department of Anatomy and Developmental Biology, University College London, Gower St, London WC1E 6BT, UK
Development 129:4335-46. 2002..Thus, cyp26 has an important role in linking the Fgf, Wnt and RA signals to regulate AP patterning of the neural ectoderm in the late blastula to gastrula embryo in zebrafish...
- AceTree: a tool for visual analysis of Caenorhabditis elegans embryogenesisThomas J Boyle
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
BMC Bioinformatics 7:275. 2006....
- Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activitySophie Dal-Pra
Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104, CNRS INSERM ULP, 1 rue Laurent Fries, BP 10142, CU de Strasbourg, 67404 Illkirch Cedex, France
Dev Biol 298:514-26. 2006....
- Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryosMartin Gering
Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
Dev Cell 8:389-400. 2005..Furthermore, HSC and DA formation also share Vegf and Notch requirements, which further distinguishes them from primitive hematopoiesis and underlines their close relationship during vertebrate development...
- Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genesMaxim Nekrasov
Gene Expression Programme, EMBL, Heidelberg, Germany
EMBO J 26:4078-88. 2007..Pcl-PRC2 is thus the HMTase that generates the high levels of H3-K27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state...
- Gastrulation in Drosophila: the logic and the cellular mechanismsM Leptin
Institut fur Genetik, Universitat zu Koln, Weyertal 121, D 50931 Köln, Germany
EMBO J 18:3187-92. 1999....
- Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservationEmily E Hare
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
PLoS Genet 4:e1000106. 2008..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
- Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoAHelen K Matthews
Department of Anatomy and Development Biology, University College London, Gower Street, London WC1E 6BT, UK
Development 135:1771-80. 2008..In addition, we show that RhoA inhibits Rac in NC cells. We present a model in which Syn4 and PCP control directional NC migration by, at least in part, regulating membrane protrusions through the regulation of small GTPase activities...
- Fgf10 regulates hepatopancreatic ductal system patterning and differentiationP Duc Si Dong
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
Nat Genet 39:397-402. 2007..These data shed light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopancreatic duct, are directed toward different organ fates...
- Multicellular rosette formation links planar cell polarity to tissue morphogenesisJ Todd Blankenship
Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
Dev Cell 11:459-70. 2006..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis...
- Pax6 induces ectopic eyes in a vertebrateR L Chow
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
Development 126:4213-22. 1999..These data show that in vertebrates, as in the invertebrate Drosophila melanogaster, Pax6 is both necessary and sufficient to trigger the cascade of events required for eye formation...
- The chromokinesin, KLP3A, dives mitotic spindle pole separation during prometaphase and anaphase and facilitates chromatid motilityMijung Kwon
University of California Davis, Davis, California 95616, USA
Mol Biol Cell 15:219-33. 2004..We propose that KLP3A acts on MTs associated with chromosome arms and the central spindle to organize ipMT bundles, to drive spindle pole separation and to facilitate chromatid motility...
- Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movementsFlorence Marlow
Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
Curr Biol 12:876-84. 2002..Moreover, how defective mediolateral cell polarity impacts CE is not understood...
- Efficient transposition of the Tol2 transposable element from a single-copy donor in zebrafishAkihiro Urasaki
Division of Molecular and Developmental Biology, National Institute of Genetics, and Department of Genetics, Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
Proc Natl Acad Sci U S A 105:19827-32. 2008..Our present study demonstrates that the in vivo Tol2 transposition system is useful for creating genome-wide insertions from a single-copy donor and should facilitate functional genomics and transposon biology in vertebrates...
- Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zonesA Prokop
Department of Zoology, University of Cambridge, United Kingdom
Neuron 17:617-26. 1996..Thus, the process of synapse formation can be genetically separated from the process of target recognition, revealing that localization of presynaptic active zones requires mef2-dependent muscle differentiation...
- Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalisJ C Corbo
Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
Development 124:589-602. 1997..We discuss the implications of this analysis with regard to the evolutionary conservation of integrative enhancers, and the subdivision of the axial and paraxial mesoderm in vertebrates...
- A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrulaM Fürthauer
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, France
Development 124:4253-64. 1997..We conclude that FGF-8 is involved in defining dorsoventral identity and is an important organizing factor responsible for specification of mesodermal and ectodermal dorsolateral territories of the zebrafish gastrula...
- FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafishJayoung Choi
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
Dev Biol 304:735-44. 2007..Taken together, our data provide the first evidence that flk1 is a direct target of FoxH1 and that FoxH1 is involved in vessel formation in zebrafish...
- Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradientAlexander Spirov
Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794 5140, USA
Development 136:605-14. 2009....
- Silencing of Smed-betacatenin1 generates radial-like hypercephalized planariansMarta Iglesias
Departament de Genetica, Universitat de Barcelona, 08028 Barcelona, Spain
Development 135:1215-21. 2008..mediterranea beta-catenins could be functionally specialized and that only Smed-betacatenin1 is involved in Wnt signalling...
- p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's diseaseSandrine Bretaud
Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK
J Neurochem 100:1626-35. 2007..Our study demonstrates the utility of zebrafish as a new animal model to study PD gene defects and suggests that modulation of downstream mechanisms, such as p53 inhibition, may be of therapeutic benefit...
- Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closureThomas H Millard
Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1DA, UK
Development 135:621-6. 2008..Finally, we characterise the behaviour of a patched-expressing cell that we observe within the engrailed region of segments A1-A5, and provide evidence that this cell contributes to cell matching...
- Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi traffickingSimeon A Boyadjiev
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Genet 38:1192-7. 2006..Our observations suggest that disrupted endoplasmic reticulum export of the secretory proteins required for normal morphogenesis accounts for CLSD...
- SegmentationDiethard Tautz
Institut für Genetik der Universität zu Köln, Weyertal 121, 50931, Germany
Dev Cell 7:301-12. 2004..An old concept of comparative anatomy, the enterocoele theory, is compatible with a single origin of segmentation mechanisms and could therefore provide a conceptual framework for assessing these molecular similarities...
- Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arraysR Leemans
Institute of Zoology, Biocenter Pharmacenter, University of Basel, CH 4056 Basel, Switzerland
Proc Natl Acad Sci U S A 97:12138-43. 2000..These results demonstrate that high-density oligonucleotide arrays are sensitive, efficient, and quantitative instruments for the analysis of large scale gene expression in Drosophila embryos...
- Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cellsTae Joo Park
Department of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
Nat Genet 40:871-9. 2008..These results demonstrate previously undescribed functions for PCP signaling components and suggest that a common signaling apparatus governs both apical docking and planar polarization of basal bodies...
- How the Dorsal gradient works: insights from postgenome technologiesJoung Woo Hong
Division of Genetics, Genomics, and Development, Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 105:20072-6. 2008..The identification of 60-70 Dorsal target genes, along with the characterization of approximately 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles...
- Neurodevelopmental defects in zebrafish (Danio rerio) at environmentally relevant dioxin (TCDD) concentrationsAdrian Hill
Laboratory for Environmental Gene Regulation, School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool Merseyside L69 7ZB, United Kingdom
Toxicol Sci 76:392-9. 2003..This disruption of neuronal development provides the basis for understanding the neurotoxic effects of these compounds...
- The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transitionW G Whitfield
Department of Biochemistry, The University, Dundee, Scotland
EMBO J 9:2563-72. 1990..These observations suggest that cyclin A has a role in the G2-M transition that is independent of spindle formation, and that entry into anaphase is a key requirement for the degradation of cyclin B...
- Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryoGeorgina E Hollway
The Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Dev Cell 12:207-19. 2007..We also show that formation of this compartment occurs via whole-somite rotation, a process that requires the action of the Sdf family of secreted cytokines...
- The role of the segmentation gene hairy in TriboliumManuel Aranda
Department of Genetics, University of Cologne, Zülpicherstrasse 47, 50674, Koln, Germany
Dev Genes Evol 218:465-77. 2008..Our results imply that there is considerable divergence in hairy function between Tribolium and Drosophila...
- Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivoKrystyna Keleman
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
Nat Neurosci 8:156-63. 2005..We show here, however, that ubiquitination of Comm is not required for its function in vitro or in vivo, and that Nedd4 is unlikely to function in axon guidance at the midline...
- Exploring embryonic germ line development in the water flea, Daphnia magna, by zinc-finger-containing VASA as a markerKazunori Sagawa
School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
Gene Expr Patterns 5:669-78. 2005..RNA analyses suggested that maternally supplied vasa mRNA was responsible for early VASA expression, while zygotic expression started during blastodermal stage of development...
- ANALYSIS OF PAIR OF RULE GENES IN SEQUENTIAL SEGMENTATIODAVID WEISBLAT; Fiscal Year: 2003..abstract_text> ..
- Spiralian developmental system for the study of multipotencyCesar Arenas Mena; Fiscal Year: 2008..The ultimate goal is to manipulate these genes and reprogram in vivo differentiated cells into multipotent stem cells. [unreadable] [unreadable] [unreadable]..
- Redox-sensitive developmental pathways and gene regulatory networksJAMES COFFMAN; Fiscal Year: 2009..Finally, the Comparative Toxicogenomics Database (CTD) at MDIBL will be used to determine the relevance of the pathways discovered in sea urchins to human health, and to generate hypotheses that might explain specific human diseases. ..
- Control of Cell Proliferation by Runx ProteinsJAMES COFFMAN; Fiscal Year: 2009..purpuratus genome sequence, which will greatly facilitate both the cis-regulatory analysis of genes and the identification of purified proteins by mass spectrometry. ..
- Bistability and Biological OscillationsJAMES FERRELL; Fiscal Year: 2009..abstract_text> ..
- EARLY EVENTS IN NEURAL AND HOMEOGENETIC INDUCTIONClaudio Stern; Fiscal Year: 2005..D. To explore the possible roles of 6 newly-identified candidate secreted factors in the early steps of neural induction and homeogenetic induction. ..
- REGULATION OF BETA-CATENIN NUCLEARIZATIONCHARLES ETTENSOHN; Fiscal Year: 2006..In addition, using dominant negative constructs and morpholinos, we will examine the developmental function of two regulators of GSK3 activity, disheveled and Akt/PKB. ..
- BIOLOGY OF BAMACAN IN TUMORIGENESISGiancarlo Ghiselli; Fiscal Year: 2006..3) The contribution of bamacan in vivo to colon tumorigenesis by generating transgenic mice over-expressing bamacan in the intestinal epithelium. ..
- Development of gonadotropin releasing hormone cellsKATHLEEN WHITLOCK; Fiscal Year: 2009....
- DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISHKATHLEEN WHITLOCK; Fiscal Year: 2004..abstract_text> ..
- Proteolytic Control of Early Events in MitosisJAMES FERRELL; Fiscal Year: 2008..abstract_text> ..
- MOLECULAR AND CELLULAR BASIS OF LENS DEVELOPMENTJonathan J Henry; Fiscal Year: 2010....
- Regulatory Genomics: BAC-GFP Library of Control GenesEric Davidson; Fiscal Year: 2008..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. ..
- MYOFIBRILLOGENESIS IN LIVING SKELETAL MUSCLE CELLSJoseph Sanger; Fiscal Year: 2004..These approaches should yield new insights into basic and pathologic processes in myofibril assembly in skeletal muscle cells. ..
- Interdisciplinary Training in Quantitative Cell BiologyRONALD VALE; Fiscal Year: 2006..In this application we request support for this exciting endeavor. ..
- Modulation of radiosensitivity in zebrafishWilliam Davidson; Fiscal Year: 2008..This work will be performed by using state-of-the-art methods of downregulating gene expression or function and has important translational ramifications. ..
- MECHANISM & FUNCTIONS OF ICH-3 IN APOPTOSIS/INFLAMMATIONJunying Yuan; Fiscal Year: 2001..These works will have direct implication in control of apoptosis in normal and inflammatory conditions. ..
- Molecular mechanism of a cellular necrotic cell death pathwayJunying Yuan; Fiscal Year: 2010..Understanding the mechanism by which cells regulate necroptotic cell death may provide unique opportunities for developing novel therapies of major human diseases with little or no known treatment. ..
- REGULATION OF CYTOKINESIS IN ANIMAL CELLSDavid Burgess; Fiscal Year: 2004..abstract_text> ..
- Genetic Analysis of Usher Syndrome in ZebrafishJONATHAN MATSUI; Fiscal Year: 2005..Both morphological and physiological studies (e.g. ERG and auditory brain stem responses) will be used. Positional cloning strategies will be used to identify the genes responsible for these mutations. ..
- ORGANOGENESIS OF THE PHARYNX IN C ELEGANSSusan E Mango; Fiscal Year: 2010..These studies will enable us to test the hypothesis that the loss of developmental plasticity is controlled by sequence-specific transcription factors in combination with global transcriptional regulatory mechanisms. ..
- Specification of embryonic C. elegans mesoderm by a T-box factorMorris Maduro; Fiscal Year: 2008..elegans may shed light on how development goes awry, a process which can lead to birth defects or cancer. [unreadable] [unreadable] [unreadable]..
- Understanding Head Development: A Segmental Groundplan of VertebratesThomas Schilling; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Development of Epibranchial Placodes and Ganglia in ZebrafishAlex Nechiporuk; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Mathematical Tools for Developmental Signaling NetworksCLAIRE TOMLIN; Fiscal Year: 2008..The long term goals are to use this research to eventually aid in understanding the corresponding signaling in humans. ..
- Development of Anti-necrosis Drug for Acute Brain InjuryJunying Yuan; Fiscal Year: 2008..This project will culminate with the filing of an IND application with the FDA in order to enter a Phase I human clinical trial. [unreadable] [unreadable] [unreadable]..
- Mechanisms of Polycomb SilencingYi Zhang; Fiscal Year: 2010..5. .Determine the transcriptional effect and understand the mechanism of H3K27 methylation and H2A ubiquitylation using a reconstituted chromatin transcription system. More description in proposal. ..
- Targeted Manipulation of the Zebrafish Genome through Homologous RecombinationBrian Ciruna; Fiscal Year: 2010....
- NONSYNDROMIC CRANIOSYNOSTOSIS: PHENOTYPE/GENOTYPE STUDYSIMEON A BOYADJIEV BOYD; Fiscal Year: 2010..In addition, we will also identify genes associated with sagittal NSC. The resources that we have amassed and the collaborative and integrated approaches that we will utilize put us in a unique position to accomplish these aims. ..
- Xenbase: a Xenopus Model Organism DatabasePETER VIZE; Fiscal Year: 2009..abstract_text> ..
- Retinoid Signaling in Neural Patterning in ZebrafishThomas Schilling; Fiscal Year: 2009....
- Spatial Control of Proteolysis in Dorsoventral PolarityELLEN LEMOSY; Fiscal Year: 2009..abstract_text> ..
- Dynamics of Proteins in the A-bands of Cardiac MuscleJoseph Sanger; Fiscal Year: 2009..The advanced imaging methods coupled with molecular biological and biochemical techniques should yield new insights into basic and pathologic processes in myofibril assembly in living cardiomyocytes. ..
- HORMONE ACTION ON THE CNSJAMES TRUMAN; Fiscal Year: 2009..Understanding these issues is fundamental to normal brain development and for using stem cells to repair brain disease. ..
- Zebrafish Heart Mutants:Physiological & Genetic AnalysesNeil Chi; Fiscal Year: 2008..These zebrafish mutants ultimately may serve as a novel gateway to gain new insight into the cellular and molecular mechanisms of human cardiac arrhythmias and heart failure. ..
- Lipid Homeostasis in C. elegansSusan Mango; Fiscal Year: 2007..unreadable] These three approaches will elucidate the transcriptional network for fat metabolism within the C. elegans digestive tract [unreadable] [unreadable]..
- Generation of a domain interaction map of C. elegans early embryogenesisMike Boxem; Fiscal Year: 2007..The integrated interaction network generated will therefore be very valuable to both C. elegans researchers and others studying animal development. [unreadable] [unreadable] [unreadable]..
- Regulation of neuronal stem cell deathErhard Bieberich; Fiscal Year: 2006..In conclusion, this study will identify mechanisms for regulation of apoptosis by ceramide that are critical for normal brain development and/or the etiology of subsequent, pathological disorders in adulthood. ..
- Zebrafish in Comparative Context: A SymposiumThomas Schilling; Fiscal Year: 2006..unreadable] [unreadable]..
- BIOMECHANICS OF LOOPING IN THE EMBRYONIC HEARTLARRY TABER; Fiscal Year: 2003..Defining the biomechanical forces involved in looping would provide insight into this morphogenetic process and thereby help researchers searching for the link between gene expression and looping morphology. ..
- Developmental Compartments of the Zebrafish NeurocraniumJohann Eberhart; Fiscal Year: 2005..Last, a forward genetic screen will be used to discover new mutations that affect the development of neurocranial cartilages. ..
- Role of caderhins in the developing zebrafish CV systemBrian Bagatto; Fiscal Year: 2005..These strengths together will produce a truly original and significant study. ..
- SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMBClifford Tabin; Fiscal Year: 2004..In these experiments the Ptc and Gli genes, which are too large for the chick viral vector system, we will be misexpressed in limbs of transgenic mice. ..
- Mechanism of Gene Silencing by DNA MethylationYi Zhang; Fiscal Year: 2005..The proposed studies will provide a thorough characterization of the MeCP1 complex. They will also reveal the potential targets and repression mechanism of the MeCP1 complex. ..
- ASSAY FOR DETERMINING DRUG TOXICITYChuenlei Parng; Fiscal Year: 2004..abstract_text> ..
- CCM proteins and vascular MAPK signal transductionMichael Malone; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Cloning and expression of sodium channel beta subunitsAmanda Hobson; Fiscal Year: 2006..Understanding nodal formation can contribute to clarifying the triggers for demyelinating disease as well as potential therapies. [unreadable] [unreadable]..
- TRAINING PROGRAM IN DEVELOPMENTAL BIOLOGYRaymond Keller; Fiscal Year: 2003..Support will be for the fist 3 years of graduate student or post- doctoral study, with the condition of good progress in training, or until individual awards are obtained. ..
- Regulation of Coronary Vessel Assembly and GrowthRobert Tomanek; Fiscal Year: 2007..Since cardiac development depends on timely and adequate vascularization, an understanding of coronary vasculogenesis and angiogenesis will provide an important foundation for our understanding of cardiac defects. ..
- Genome wide analysis and modeling of signal integration in the Drosophila ovaryStanislav Shvartsman; Fiscal Year: 2009..Given the highly conserved nature of these signaling pathways, our results will provide quantitative insights into the mechanisms of signaling crosstalk in developing and adult tissues. ..
- RNA PROCESSING AND RIBONUCLEOPROTEINThoru Pederson; Fiscal Year: 2001..The same studies should provide information on sequences required for nuclear export. These two inter-related projects test the hypothesis that the nucleolus is a more pluri-functional organelle than previously thought. ..
- Body Plan Formation in Early Mouse EmbryoYusuke Marikawa; Fiscal Year: 2004....
- ANGIOGENIC THERAPY FOR INFARCTED AND ISCHEMIC HEARTRobert Tomanek; Fiscal Year: 2003..Such interventions have a number of advantages over more invasive interventions, e.g., the delivery of oxogenous growth factors or gene therapy. ..
- AVIAN VASCULAR FUNCTIONHiroko Nishimura; Fiscal Year: 2007..The proposed projects will be supported by five distinguished consultants. [unreadable] [unreadable]..
- Control of Spemann's organizerMichael Sheets; Fiscal Year: 2007..We will address our view by examining the role(s) of FGF signaling pathway(s) within the organizer and the transcription of chordin as they relate to the ultimate inducing functions of Spemann's organizer. [unreadable] [unreadable]..
- STEROID RECEPTORS AND CNS DEVELOPMENTJAMES TRUMAN; Fiscal Year: 2007..5) Use EcR dominant-negative mutations to selectively suppress cytodynamic modules to establish the role of each on growth dynamics and on the final form of the arbor. ..
- Predoctoral Fellowship for Minority StudentsLisa Chang; Fiscal Year: 2006..Some of these include microarray screening, DNA-binding assays, microinjection, microsurgery, in-situ hybridization, antisense and dominant negative inhibition of gene function, and transgenics. ..
- REGULATION OF CARDIAC MYOGENESISPARKER ANTIN; Fiscal Year: 2002..This information will increase our understanding of both normal and abnormal heart development and may suggest ways to alter heart development or replication of cardiac myocytes. ..
- Hemichordartes and the Origin of ChordatesJohn Gerhart; Fiscal Year: 2009..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
- Analysis of endocytosis in Caenorhabditis elegansHanna Fares; Fiscal Year: 2006..New genes identified in worms will also be studied in humans through collaborations with researchers who study this process. ..
- Cell Cycle Regulation by Checkpoints in DrosophilaTin Tin Su; Fiscal Year: 2006..Aim 4) We will screen through existing mutagensensitive Drosophila mutants for their ability to regulate mitosis, S phase and cell death after irradiation, in order to uncover novel genes needed for proper response to DNA damage. ..
- An in vivo Screen for Radiation SensitizersTin Tin Su; Fiscal Year: 2008..Successful completion of this project would establish a novel, rapid and effective primary screen in vivo for radiosensitizers with potential therapeutic value. [unreadable] [unreadable] [unreadable]..
- Cell Growth and Radiation Survival in DrosophilaTin Tin Su; Fiscal Year: 2007..Understanding radiation survival in a multicellular context could help identify potential therapies for when we do not want cells to survive irradiation, such as in the treatment of cancer. ..
- GEISHA, a Chicken Embryo Gene Expression ResourcePARKER ANTIN; Fiscal Year: 2009..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
- STUDY OF INSULATOR FUNCTION IN DROSOPHILAHAINI CAI; Fiscal Year: 2005..abstract_text> ..
- Functional Genomics in a Simple Model MetazoanMARK MARTINDALE; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Site-specific transgenesis in zebrafishJAMES LISTER; Fiscal Year: 2008..These tools will advance the usefulness of this model organism as a model for human development and disease. [unreadable] [unreadable] [unreadable]..