hindlimb

Summary

Summary: Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)

Top Publications

  1. ncbi Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington, DC 20010, USA
    Circulation 109:1543-9. 2004
  2. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
  3. ncbi Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases
    Chang Hwan Yoon
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Circulation 112:1618-27. 2005
  4. ncbi Variations in surgical procedures for hind limb ischaemia mouse models result in differences in collateral formation
    A A Hellingman
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Vasc Endovasc Surg 40:796-803. 2010
  5. ncbi Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci Methods 115:169-79. 2002
  6. ncbi Augmentation of postnatal neovascularization with autologous bone marrow transplantation
    S Shintani
    Cardiovascular Research Institute and the Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    Circulation 103:897-903. 2001
  7. ncbi Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis
    Jin Hur
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Korea
    Arterioscler Thromb Vasc Biol 24:288-93. 2004
  8. ncbi Responses of infragranular neurons in the rat primary somatosensory cortex to forepaw and hindpaw tactile stimuli
    K A Moxon
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Neuroscience 156:1083-92. 2008
  9. ncbi Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    C Chiang
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Dev Biol 236:421-35. 2001
  10. ncbi Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells
    Po Hsun Huang
    Division of Cardiology, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 29:1179-84. 2009

Detail Information

Publications330 found, 100 shown here

  1. ncbi Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington, DC 20010, USA
    Circulation 109:1543-9. 2004
    ..Bone marrow cell therapy is reported to contribute to collateral formation through cell incorporation into new or remodeling vessels. However, the possible role of a paracrine contribution to this effect is less well characterized...
  2. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
    ..These findings provide a strategy by which individuals with spinal cord injuries could regain substantial levels of motor control...
  3. ncbi Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases
    Chang Hwan Yoon
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Circulation 112:1618-27. 2005
    ..We also investigated whether the combination of these different cell types shows synergism during neovascularization...
  4. ncbi Variations in surgical procedures for hind limb ischaemia mouse models result in differences in collateral formation
    A A Hellingman
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Vasc Endovasc Surg 40:796-803. 2010
    ..To identify the optimal mouse model for hind limb ischaemia, which offers a therapeutic window that is large enough to detect improvements of blood flow recovery, for example, using cell therapies...
  5. ncbi Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci Methods 115:169-79. 2002
    The ladder rung walking test is a new task to assess skilled walking and measure both forelimb and hindlimb placing, stepping, and inter-limb co-ordination...
  6. ncbi Augmentation of postnatal neovascularization with autologous bone marrow transplantation
    S Shintani
    Cardiovascular Research Institute and the Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    Circulation 103:897-903. 2001
    ..of autologous BM-MNCs might augment angiogenesis and collateral vessel formation in a rabbit model of hindlimb ischemia...
  7. ncbi Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis
    Jin Hur
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Korea
    Arterioscler Thromb Vasc Biol 24:288-93. 2004
    ..Endothelial progenitor cells (EPC) in one study group is not the same as EPC in other investigators, suggesting that EPC is not a single type of cell population. In this study, we tried to demonstrate the heterogeneity of EPC...
  8. ncbi Responses of infragranular neurons in the rat primary somatosensory cortex to forepaw and hindpaw tactile stimuli
    K A Moxon
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Neuroscience 156:1083-92. 2008
    ....
  9. ncbi Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    C Chiang
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Dev Biol 236:421-35. 2001
    ..The forelimb autopod is represented by a single distal cartilage element, while the hindlimb autopod is invariably composed of a single digit with well-formed interphalangeal joints and a dorsal nail bed at ..
  10. ncbi Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells
    Po Hsun Huang
    Division of Cardiology, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 29:1179-84. 2009
    ..Here we show that the impaired neovascularization in mice lacking MMP-9 is related to a defect in EPC functions in vasculogenesis...
  11. ncbi Endothelial progenitor cells: characterization and role in vascular biology
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 95:343-53. 2004
    ..This review summarizes the mechanisms regulating endothelial progenitor cell-mediated neovascularization and reendothelialization...
  12. ncbi Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice
    Dimitri Scholz
    Department of Exp Cardiology, Max Planck Institute, Bad Nauheim, Germany
    J Mol Cell Cardiol 34:775-87. 2002
    ..Acute collateral blood flow to the hindlimb was lowest in Balb/C mice, causing intense ischemia, and showed a slower recovery (more than 21 days to 50% ..
  13. pmc Motoneuronal and muscle synergies involved in cat hindlimb control during fictive and real locomotion: a comparison study
    Sergey N Markin
    Dept of Neurobiology and Anatomy, Drexel Univ College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 107:2057-71. 2012
    ..decerebrate cat preparations by midbrain stimulation to the activity profiles and synergies of the corresponding hindlimb muscles obtained during forward level walking in cats...
  14. pmc Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats
    Vanessa S Boyce
    Department of Neurobiology and Behavior, Life Sciences Building, Room 532, State University of New York at Stony Brook, Stony Brook, NY 11794 5230, USA
    Eur J Neurosci 35:221-32. 2012
    ..In fact, AAV-BDNF-treated rats displayed plantar, weight-supported hindlimb stepping on a stationary platform, that is, without the assistance of a moving treadmill and without step ..
  15. ncbi Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2
    Matthias Heil
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Circ Res 94:671-7. 2004
    ..Three weeks after femoral artery ligation, LDI perfusion ratio of operated versus nonoperated distal hindlimb in BALB/c wild-type mice increased to 0.45+/-0.06 and in CCR2(-/-) animals only to 0.21+/-0.03 (P<0.01)...
  16. ncbi Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis
    S E Bove
    Department of Inflammation Pharmacology, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, MI 48105, USA
    Osteoarthritis Cartilage 11:821-30. 2003
    ....
  17. pmc Dissociation between peripheral blood chimerism and tolerance to hindlimb composite tissue transplants: preferential localization of chimerism in donor bone
    Dina N Rahhal
    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY 40202 1760, USA
    Transplantation 88:773-81. 2009
    ..Mixed chimerism induces donor-specific tolerance to composite tissue allotransplants (CTAs). In the present studies, we used a nonmyeloablative conditioning approach to establish chimerism and promote CTA acceptance...
  18. pmc Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice
    Yasuhiko Kawakami
    Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Development 138:4465-73. 2011
    ..Specifically, involvement of the β-catenin pathway in limb initiation, as well as its role in hindlimb-specific transcriptional regulation, are under debate...
  19. ncbi Bone marrow-derived cells do not incorporate into the adult growing vasculature
    Tibor Ziegelhoeffer
    Max Planck Institute for Clinical and Physiological Research, Bad Nauheim, Germany
    Circ Res 94:230-8. 2004
    ..We investigated whether bone marrow-Derived cells incorporate into vessels using mouse models of hindlimb ischemia (arteriogenesis and angiogenesis) and tumor growth...
  20. pmc Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia
    Norifumi Urao
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Circ Res 103:212-20. 2008
    ..Here we show that hindlimb ischemia of mice significantly increases Nox2 expression and ROS production in BM-mononuclear cells (BMCs), which ..
  21. ncbi Improvement of postnatal neovascularization by human embryonic stem cell derived endothelial-like cell transplantation in a mouse model of hindlimb ischemia
    Seung Woo Cho
    Department of Bioengineering, Hanyang University, Seoul, Korea
    Circulation 116:2409-19. 2007
    We established an efficient preparation method to obtain endothelial-like cells (ECs) from human embryonic stem cells (hESCs) and tested whether these hESC-ECs would show therapeutic potential for treatment of hindlimb ischemia.
  22. ncbi Arteriogenesis versus angiogenesis: similarities and differences
    M Heil
    Max Planck Institute for Heart and Lung Research, Parkstrasse 1, 61231 Bad Nauheim, Germany
    J Cell Mol Med 10:45-55. 2006
    ..In contrast, the initial hypothesis that these cells -after undergoing a (trans-)differentiation- contribute by a structural integration into the growing vessel wall, is increasingly challenged...
  23. ncbi Hindlimb stepping movements in complete spinal rats induced by epidural spinal cord stimulation
    R M Ichiyama
    Department of Physiological Science, University of California, Los Angeles, 1804 Life Science Building, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neurosci Lett 383:339-44. 2005
    ..Bilateral hindlimb locomotor activity was evoked most often with epidural stimulation at 40-50 Hz applied at the L2 segment...
  24. pmc Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb
    Ju Suk Nam
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 311:124-35. 2007
    ..we report that targeted inactivation of the mouse Rspo2 gene causes developmental limb defects, especially in the hindlimb. Although the initiation of the expression of apical ectodermal ridge (AER)-specific genes, including fibroblast ..
  25. ncbi Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model
    Yoshihiko Kakinuma
    Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Mol Cell Cardiol 48:680-93. 2010
    ..We evaluated the effects of donepezil on angiogenic properties in vitro and in vivo, using an ischemic hindlimb model of alpha7 nicotinic receptor-deleted mice (alpha7 KO) and wild-type mice (WT)...
  26. ncbi Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia
    Takashi Iwase
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Cardiovasc Res 66:543-51. 2005
    ..Accordingly, we injected equal numbers of MSC or MNC in a rat model of hindlimb ischemia and compared their therapeutic potential.
  27. pmc Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions
    D G Flood
    Department of Molecular Biology, Cephalon, Inc, West Chester, Pennsylvania, USA
    Am J Pathol 155:663-72. 1999
    ..SOD1(-/-) mice developed a chronic peripheral hindlimb axonopathy...
  28. ncbi Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis
    Johannes Jacobi
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif 94305, USA
    Circulation 111:1431-8. 2005
    ....
  29. ncbi Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model
    Tsunetatsu Namba
    Division of Clinical Gene Therapy, Osaka University Medical School, 2 2 Yamada oka, Suita 565 0871, Osaka, Japan
    Circulation 108:2250-7. 2003
    ....
  30. ncbi Organization of lumbosacral motoneuronal cell groups innervating hindlimb, pelvic floor, and axial muscles in the cat
    V G VanderHorst
    Department of Anatomy, University of Groningen, The Netherlands
    J Comp Neurol 382:46-76. 1997
    In a study on descending pathways from the nucleus retroambiguus (NRA) to hindlimb motoneurons (see accompanying paper), it appeared impossible, using data from the literature, to precisely determine which muscles were innervated by the ..
  31. ncbi Metamorphosis-induced changes in the coupling of spinal thoraco-lumbar motor outputs during swimming in Xenopus laevis
    Anna Beyeler
    Universite de Bordeaux, Centre National de la Recherche Scientifique, Laboratoire Mouvement Adaptation Cognition UMR 5227 Bordeaux, France
    J Neurophysiol 100:1372-83. 2008
    ..interact during locomotion in juvenile Xenopus, we have investigated the coordination between postural back and hindlimb muscle activity during free forward swimming...
  32. ncbi Grafting of fetal brainstem 5-HT neurons into the sublesional spinal cord of paraplegic rats restores coordinated hindlimb locomotion
    Urszula Sławińska
    Laboratory of Neuromuscular Plasticity, Department of Neurophysiology, Nencki Institute of Experimental Biology PAS, Warsaw, Poland
    Exp Neurol 247:572-81. 2013
    ..These results are consistent with the roles for these receptors during locomotion in intact rodents and in rodent brainstem-spinal cord in vitro preparations...
  33. ncbi Impaired arteriogenic response to acute hindlimb ischemia in CD4-knockout mice
    Eugenio Stabile
    Laboratory of Vascular Biology, Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Suite 4B 1, 110 Irving Street, NW, Washington, DC 20010, USA
    Circulation 108:205-10. 2003
    ..Because CD4+ T lymphocytes are active in regulating humoral and cellular responses of the immune system, we determined whether CD4+ cells contribute to collateral vessel development by using the mouse ischemic hindlimb model.
  34. ncbi Effect of electroacupuncture stimulation of hindlimb on seizure incidence and supragranular mossy fiber sprouting in a rat model of epilepsy
    Jianjun Guo
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, People s Republic of China
    J Physiol Sci 58:309-15. 2008
    ..The present study was designed to assess the effect of EA stimulation of hindlimb on the incidence of behavioral seizures (spontaneous recurrent seizures, [SRS]) and electroencephalogram (EEG) ..
  35. pmc Forelimb EMG-based trigger to control an electronic spinal bridge to enable hindlimb stepping after a complete spinal cord lesion in rats
    Parag Gad
    Biomedical Engineering IDP, University of California, Los Angeles, CA 90095, USA
    J Neuroeng Rehabil 9:38. 2012
    ..The objective of this study was to develop an electronic bridge across the lesion of the spinal cord to facilitate hindlimb stepping after a complete mid-thoracic spinal cord injury in adult rats.
  36. ncbi Pharmacological assessment of the rat formalin test utilizing the clinically used analgesic drugs gabapentin, lamotrigine, morphine, duloxetine, tramadol and ibuprofen: influence of low and high formalin concentrations
    Gordon Munro
    Department of Pharmacology, Neurosearch A S, Ballerup, Denmark
    Eur J Pharmacol 605:95-102. 2009
    ....
  37. pmc MicroRNA-93 controls perfusion recovery after hindlimb ischemia by modulating expression of multiple genes in the cell cycle pathway
    Surovi Hazarika
    Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Circulation 127:1818-28. 2013
    ..we used an unbiased strategy and took advantage of different phenotypic outcomes that follow surgically induced hindlimb ischemia between inbred mouse strains to identify key microRNAs involved in perfusion recovery from hindlimb ..
  38. ncbi Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization
    Clément Cochain
    Paris Cardiovascular Research Center, Universite Paris Descartes, UMR S970 Paris, France
    Cardiovasc Res 88:186-95. 2010
    ..Here, we hypothesized that distinct chemokine/chemokine receptor pathways, namely CCL2/CCR2, CX3CL1/CX3CR1, and CCL5/CCR5, differentially control monocyte subset systemic levels, and might thus impact post-ischaemic vessel growth...
  39. pmc An in vitro spinal cord-hindlimb preparation for studying behaviorally relevant rat locomotor function
    Heather Brant Hayes
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Neurophysiol 101:1114-22. 2009
    ..accessibility of in vitro preparations with the modulatory influence of sensory feedback from physiological hindlimb movement...
  40. ncbi Accuracy of asymmetry indices of ground reaction forces for diagnosis of hind limb lameness in dogs
    Laurent Fanchon
    Unité de Médecine de l Elevage et du Sport, Ecole Nationale Veterinaire d Alfort, 94700 Maisons, Alfort, France
    Am J Vet Res 68:1089-94. 2007
    ..To determine the accuracy of asymmetry indices of ground reaction forces (GRF) for diagnosis of hind limb lameness in dogs...
  41. ncbi A dual role for Hox genes in limb anterior-posterior asymmetry
    Jozsef Zakany
    Department of Zoology and Animal Biology and National Program Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Science 304:1669-72. 2004
    ..This signal is subsequently translated into digit morphological asymmetry by promoting the late expression of Hoxd genes, two collinear processes relying on opposite genomic topographies, upstream and downstream Shh signaling...
  42. pmc How spinalized rats can walk: biomechanics, cortex, and hindlimb muscle scaling--implications for rehabilitation
    Simon F Giszter
    Neurobiology and Anatomy, School of Bioengineering, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1198:279-93. 2010
    ..Pattern generation may be built into the lumbar spinal cord by evolution and matched to the limb biomechanics, so preserved muscle scaling may be essential to the NST function observed...
  43. ncbi Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat
    Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643 Pecs, Szigeti u 12, Hungary
    Arthritis Rheum 50:1677-85. 2004
    ..This study was undertaken to examine this systemic "sensocrine" function of neuronally derived somatostatin in chronic inflammation in the Freund's complete adjuvant (CFA)-induced arthritis model...
  44. ncbi Recovery of hindlimb motor functions after spinal cord transection is enhanced by grafts of the embryonic raphe nuclei
    U Sławińska
    Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw
    Exp Brain Res 132:27-38. 2000
    ..Two months later the recovery of hindlimb motor function in rats which had received a transplant of neural tissue (ST rats) was much better than in spinal ..
  45. pmc Developmental segregation of spinal networks driving axial- and hindlimb-based locomotion in metamorphosing Xenopus laevis
    D Combes
    Laboratoire de Physiologie et Physiopathologie de la Signalization Cellulaire, UMR CNRS 5543, Universités Bordeaux 1 and Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    J Physiol 559:17-24. 2004
    ..axial swimming, whereas postmetamorphic animals expressed motor patterns appropriate for bilaterally synchronous hindlimb flexion-extension kicks...
  46. ncbi Back seat driving: hindlimb corticospinal neurons assume forelimb control following ischaemic stroke
    Michelle Louise Starkey
    Department of Health Sciences and Technology, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Brain 135:3265-81. 2012
    ..spinal cord showed a correlation between the number of cervically projecting corticospinal neurons present in the hindlimb sensory-motor cortex and good behavioural recovery...
  47. ncbi The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination
    Guido C Koopmans
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, Maastricht, The Netherlands
    J Neurotrauma 22:214-25. 2005
    ..A limitation within the BBB locomotor rating scale is the correct assessment of forelimb (FL)-hindlimb (HL) coordination. This limitation can have major implications for the final assessment of locomotor function...
  48. pmc Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice
    Malgorzata Milkiewicz
    Department of Physiology, University of Birmingham, Birmingham B15 2TT, UK
    J Physiol 560:21-6. 2004
    ..The findings indicate that treatment with DMOG has a potential therapeutic use in promoting angiogenesis in ischaemic diseases, and perhaps for improving muscle recovery after injury, exercise or training...
  49. ncbi Pretreatment with the nitric oxide donor SNAP or nerve transection blocks humoral preconditioning by remote limb ischemia or intra-arterial adenosine
    Tor Steensrud
    Department of Cardio Thoracic and Vascular Surgery, University Hospital North Norway, Tromsø, Norway
    Am J Physiol Heart Circ Physiol 299:H1598-603. 2010
    ..These results may be important when designing or assessing the results of clinical trials of adenosine or rIPC cardioprotection, where NO donors are used as part of therapy...
  50. ncbi Dietary apple polyphenols have preventive effects against lengthening contraction-induced muscle injuries
    Koichi Nakazato
    Department of Exercise Physiology, Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan
    Mol Nutr Food Res 54:364-72. 2010
    ..The APP group had significantly higher glutathione-S-transferase alpha1 mRNA levels than the CON group. Therefore, we conclude that dietary APPs have protective effects against lengthening contraction-induced muscle injury...
  51. ncbi Effects of 14 days of microgravity on fast hindlimb and diaphragm muscles of the rat
    Mark D Schuenke
    Department of Anatomy, College of Osteopathic Medicine, University of New England, 431 Stella Maris, Biddeford, NE 04005, USA
    Eur J Appl Physiol 106:885-92. 2009
    ..2000). Hindlimb muscles containing predominately fast fibers [extensor digitorum longus (EDL), superficial "white" (GSW) and deep ..
  52. pmc Electromyographic responses from the hindlimb muscles of the decerebrate cat to horizontal support surface perturbations
    Claire F Honeycutt
    Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 0356, USA
    J Neurophysiol 101:2751-61. 2009
    ..were applied to all four limbs and electromyographic recordings were collected from 14 muscles of the right hindlimb. Muscle activation was quantified with tuning curves, which compared increases and decreases in muscle activity ..
  53. ncbi Natural killer cells and CD4+ T-cells modulate collateral artery development
    V van Weel
    Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2310-8. 2007
    ..Here, we studied the role of lymphocytes in a murine model of hindlimb ischemia.
  54. ncbi Impact of mouse strain differences in innate hindlimb collateral vasculature
    Armin Helisch
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Arterioscler Thromb Vasc Biol 26:520-6. 2006
    ..To assess the importance of genetic background for collateral artery development...
  55. ncbi The neural and humoral pathways in remote limb ischemic preconditioning
    Shiang Y Lim
    The Hatter Cardiovascular Institute, University College London Hospital and Medical School, UK
    Basic Res Cardiol 105:651-5. 2010
    ..In conclusion, remote limb ischaemic preconditioning reduced myocardial infarct size in the mice in a manner which implicates both a neural and humoral pathway...
  56. pmc Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth
    Won Gil Cho
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 106:7137-42. 2009
    ..both hemangiogenesis and lymphangiogenesis in mouse models of neovascularization induced by corneal sutures or hindlimb ischemia as efficiently as a 21-nt siRNA targeting vascular endothelial growth factor-A...
  57. ncbi Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease
    Y Taniyama
    Department of Geriatric Medicine, Biomedical Research Center, Osaka University Medical School, Japan
    Gene Ther 8:181-9. 2001
    ..have previously reported that intra-arterial administration of recombinant HGF induced angiogenesis in a rabbit hindlimb ischemia model...
  58. ncbi Haeme oxygenase promotes progenitor cell mobilization, neovascularization, and functional recovery after critical hindlimb ischaemia in mice
    Jörn Tongers
    Department of Cardiology and Angiology, Hannover University Medical School, 30625 Hannover, Germany
    Cardiovasc Res 78:294-300. 2008
    ..We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI).
  59. pmc Does elimination of afferent input modify the changes in rat motoneurone properties that occur following chronic spinal cord transection?
    Duane C Button
    Spinal Cord Research Centre, Department of Physiology, University of Manitoba, 730 William Avenue, 436 BMSB, Winnipeg, Manitoba, Canada R3E 3J7
    J Physiol 586:529-44. 2008
    ..inputs), compared with the same duration of spinal cord transection (ST, removal of descending input only) on hindlimb motoneurone biophysical properties...
  60. ncbi Gene therapy with the angiogenic cytokine secretoneurin induces therapeutic angiogenesis by a nitric oxide-dependent mechanism
    Wilfried Schgoer
    Department of Internal Medicine 1, Medical University of Innsbruck, Austria
    Circ Res 105:994-1002. 2009
    ..The neuropeptide secretoneurin induces angiogenesis and postnatal vasculogenesis and is upregulated by hypoxia in skeletal muscle cells...
  61. ncbi A novel model of acute murine hindlimb ischemia
    Robert S Crawford
    Department of Surgery, Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, 15 Parkman St, Ste 458, Boston, MA 02114, USA
    Am J Physiol Heart Circ Physiol 292:H830-7. 2007
    ..ligator (MHL), a band designed to cause tissue necrosis, is the preferred experimental tool to create hindlimb ischemia-reperfusion (I/R) injury in rodents...
  62. pmc Forelimb-hindlimb developmental timing changes across tetrapod phylogeny
    Olaf R P Bininda-Emonds
    Institute of Biology, University of Leiden, Kaiserstraat 63, 2311GP, Leiden, The Netherlands
    BMC Evol Biol 7:182. 2007
    ..histological sections were used to code the appearance of 10 developmental events comprising landmarks of development from the early bud stage to late chondrogenesis in the forelimb and the corresponding serial homologues in the hindlimb.
  63. pmc The extent of the preserved feathers on the four-winged dinosaur Microraptor gui under ultraviolet light
    David W E Hone
    Key Laboratory of Evolutionary Systematics of Vertebrates, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 5:e9223. 2010
    ..This taxon has important implications for the origin of flight in birds and the possibility of a four-winged gliding phase...
  64. ncbi Differential involvement of excitatory and inhibitory neurons of cat motor cortex in coincident spike activity related to behavioral context
    David Putrino
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 30:8048-56. 2010
    ..NTR and TR neurons showed associations in their firing patterns over wide areas of MI (representing forelimb and hindlimb movements) during quiet sitting, more commonly involving RS neurons...
  65. ncbi A nearly modern amphibious bird from the Early Cretaceous of northwestern China
    Hai Lu You
    Institute of Geology, Chinese Academy of Geological Sciences, 26 Baiwanzhuang Road, Beijing 100037, People s Republic of China
    Science 312:1640-3. 2006
    ..The anatomy of Gansus, like that of other non-neornithean (nonmodern) ornithuran birds, indicates specialization for an amphibious life-style, supporting the hypothesis that modern birds originated in aquatic or littoral niches...
  66. pmc Pre-symptomatic detection of chronic motor deficits and genotype prediction in congenic B6.SOD1(G93A) ALS mouse model
    C R Hayworth
    Department of Psychology, Institute for Neuroscience, University of Texas at Austin, 2701 Speedway, Austin, TX 78712, USA
    Neuroscience 164:975-85. 2009
    ..In addition, two physical measures of muscle girth revealed progressive hindlimb muscle atrophy that predicted genotype in individual pre-symptomatic mice with 80% accuracy...
  67. ncbi Effects of the hindlimb-unloading model of spaceflight conditions on resistance of mice to infection with Klebsiella pneumoniae
    Tesfaye Belay
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495
    J Allergy Clin Immunol 110:262-8. 2002
    ..b>Hindlimb (antiorthostatic) unloading of rodents has been used successfully to simulate some of the effects of spaceflight ..
  68. ncbi Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia
    Anna F Milia
    Cardiovascular Medicine and Gene Therapy Section, National Laboratory of the National Institute of Biostructures and Biosystems, Osilo, Sassari, Italy
    Circ Res 91:346-52. 2002
    ..In conclusions, our study is the first to demonstrate the angiogenic potential of PAR-2 stimulation in vivo. If similar effects occur in humans, PAR-2AP agonists could have some therapeutic potential for the treatment of tissue ischemia...
  69. ncbi Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo
    Pooja Agarwal
    Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 130:623-33. 2003
    ..Tbx5 is not essential for an early establishment of forelimb versus hindlimb identity...
  70. ncbi Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats
    Vanessa S Boyce
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neurophysiol 98:1988-96. 2007
    ..Finally, the results show that transplants beneficial in rodents are applicable to larger mammals...
  71. pmc Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity
    Natalia V De Marco Garcia
    Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:217-31. 2008
    ..Our findings provide genetic evidence that neurons within motor pools possess an early transcriptional identity that controls target muscle specificity...
  72. ncbi Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia
    Jewon Ryu
    Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong Songpa gu 138 736, Seoul 138 736, Republic of Korea
    Cardiovasc Res 78:333-40. 2008
    ..The present study investigated the detailed mechanism by which fractalkine (Fkn), a CX3C chemokine, induces angiogenesis and its functional implication in alleviating ischaemia in vivo...
  73. pmc High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism
    Federico Biscetti
    Laboratory of Vascular Biology and Genetics, Department of Medicine, A Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy
    Diabetes 59:1496-505. 2010
    ..To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice...
  74. ncbi Modulation and vectorial summation of the spinalized frog's hindlimb end-point force produced by intraspinal electrical stimulation of the cord
    M A LeMay
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    IEEE Trans Neural Syst Rehabil Eng 9:12-23. 2001
    ..recording forces at the ankle; and, at the muscular level by recording the electromyographic (EMG) activity of 11 hindlimb muscles...
  75. ncbi Time course of arteriogenesis following femoral artery occlusion in the rabbit
    I E Hoefer
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Benekestr 2, D 61231, Bad Nauheim, Germany
    Cardiovasc Res 49:609-17. 2001
    ..We examined the time course of arteriogenesis (collateral artery growth) after femoral artery ligation and the effect of monocyte chemoattractant protein-1 (MCP-1)...
  76. ncbi Anabolism. Low mechanical signals strengthen long bones
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
    Nature 412:603-4. 2001
    ..As the strain levels generated by this treatment are three orders of magnitude below those that damage bone tissue, this anabolic, non-invasive stimulus may have potential for treating skeletal conditions such as osteoporosis...
  77. ncbi Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limb function
    B Blits
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Neuroscience 118:271-81. 2003
    ..Our results suggest that AAV vector-mediated overexpression of BDNF and NT-3 in the cord caudal to a Schwann cell bridge modified the local lumbar axonal circuitry, which was beneficial for locomotor function...
  78. ncbi Do human bipeds use quadrupedal coordination?
    Volker Dietz
    ParaCare, Institute for Rehabilitation and Research, University Hospital Balgrist, Forchstrasse 340, 8008 Zurich, Switzerland
    Trends Neurosci 25:462-7. 2002
    ..The persistence of such movement control has consequences for rehabilitation and the applicability of animal research to human patients with spinal cord injury...
  79. ncbi Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: evidence suggesting cross-species protection
    Mikiko Shimizu
    Division of Cardiology, Hospital for Sick Children, Toronto, Canada
    Clin Sci (Lond) 117:191-200. 2009
    ..This cardioprotection is transferable across species, independent of local neurogenic activity, and requires opioid receptor activation...
  80. ncbi Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis
    Imo E Hoefer
    Department of Cardiology, University of Freiburg, Germany
    Circulation 105:1639-41. 2002
    ..We hypothesized that arteriogenesis is reduced in mice lacking functional TNF-alpha or p55 receptor. To test this hypothesis, we developed a novel microsphere-based murine model of hindlimb perfusion measurement.
  81. pmc The Mouse Limb Anatomy Atlas: an interactive 3D tool for studying embryonic limb patterning
    April DeLaurier
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    BMC Dev Biol 8:83. 2008
    ..Existing textual references consist of two-dimensional (2D) illustrations of the adult rat or mouse limb that can be difficult to apply when attempting to describe the complex three-dimensional (3D) relationship between tissues...
  82. ncbi Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord
    Karim Fouad
    University of Alberta, Faculty of Rehabilitation Medicine, Edmonton, Canada T6G 2G4
    J Neurosci 25:1169-78. 2005
    ..Significant improvements were observed in the Basso, Beattie, and Bresnahan score and in forelimb/hindlimb coupling...
  83. ncbi Rewiring of hindlimb corticospinal neurons after spinal cord injury
    Arko Ghosh
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Nat Neurosci 13:97-104. 2010
    ..Large thoracic spinal cord injuries in adult rats result in impairments of hindlimb function...
  84. ncbi Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization
    Christopher Heeschen
    Department of Internal Medicine IV and Hematology, University of Frankfurt, Germany
    Blood 102:1340-6. 2003
    ..Epo appears to physiologically regulate EPC mobilization in patients with ischemic heart disease. Thus, Epo serum levels may help in identifying patients with impaired EPC recruitment capacity...
  85. ncbi Fiber type composition of four hindlimb muscles of adult Fisher 344 rats
    R S Staron
    Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens 45701, USA
    Histochem Cell Biol 111:117-23. 1999
    ..of histochemically defined "pure" and "hybrid" fiber types in untreated muscles of the young adult Fisher 344 rat hindlimb. The selected hindlimb muscles (soleus, tibialis anterior, extensor digitorum longus, and gastrocnemius muscles) ..
  86. ncbi Hindlimb patterning and mandible development require the Ptx1 gene
    C Lanctot
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Montreal Quebec, Canada H2W 1R7
    Development 126:1805-10. 1999
    ..has suggested that it may play a role in specification of posterior structures, in particular, specification of hindlimb identity. Ptx1 is also expressed in the most anterior ectoderm, the stomodeum, and in the first branchial arch...
  87. ncbi p66ShcA modulates tissue response to hindlimb ischemia
    Germana Zaccagnini
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata IRCCS, Rome, Italy
    Circulation 109:2917-23. 2004
    ....
  88. ncbi Pain related behaviour in two models of osteoarthritis in the rat knee
    Janet Fernihough
    Novartis Institute for Medical Sciences, 5 Gower Place, London WCE 6BS, UK
    Pain 112:83-93. 2004
    ..Gabapentin varied in its ability to reverse both hyperalgesia and allodynia. The iodoacetate model provides a basis for studies on the mechanisms of pain in OA, and for development of novel therapeutic analgesics...
  89. ncbi Elevated fluid shear stress enhances postocclusive collateral artery growth and gene expression in the pig hind limb
    Frederic Pipp
    Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, D 61231 Germany
    Arterioscler Thromb Vasc Biol 24:1664-8. 2004
    ..Therefore, we studied the influence of FSS on arteriogenesis in a new model with extremely high levels of collateral flow and FSS in pig and rabbit hind limbs...
  90. pmc Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb
    M Arras
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, D 61231 Bad Nauheim, Germany
    J Clin Invest 101:40-50. 1998
    ..8 ml/min/100 mmHg vs. 45+/-6.8 ml/min/100 mmHg; P < 0.05) as compared with untreated animals after 7 d of occlusion. These results indicate that monocyte activation plays a major role in angiogenesis and collateral artery growth...
  91. ncbi Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching
    Chad Johnson
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology Emory University School of Medicine, Atlanta, GA, USA
    Circ Res 94:262-8. 2004
    ..Our study indicates that angiogenesis triggered by tissue ischemia requires MMP-9, which may be involved in capillary branching, a potential novel role for this MMP that could be exploited to control angiogenesis...
  92. ncbi Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction
    Magdi M I Yassin
    Department of Surgery, The Queen s University of Belfast, Institute of Clinical Sciences, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, UK
    World J Surg 26:115-21. 2002
    ..001). Morbidity and mortality following reperfusion of the acutely ischemic limb may be a manifestation of multiple organ dysfunction caused by a systemic inflammatory response triggered by reperfusion of the ischemic extremities...
  93. ncbi Improvement of postnatal neovascularization by human adipose tissue-derived stem cells
    A Miranville
    Department of Cardiovascular Physiology, J W Goethe University, Frankfurt, Germany
    Circulation 110:349-55. 2004
    ..Several studies have suggested that stem cells are present in the stroma-vascular fraction (SVF) of adipose tissue (AT)...
  94. ncbi Deletions of rhythmic motoneuron activity during fictive locomotion and scratch provide clues to the organization of the mammalian central pattern generator
    Myriam Lafreniere-Roula
    Spinal Cord Research Centre and Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Neurophysiol 94:1120-32. 2005
    ..Deletions of activity were observed both in hindlimb flexor and extensor motoneuron pools during brain stem-stimulation-evoked fictive locomotion but only in ..
  95. ncbi Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia
    Taiki Tojo
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circulation 111:2347-55. 2005
    ..The role of gp91phox-derived ROS in neovascularization in response to tissue ischemia is unknown, however...
  96. pmc Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction
    Gennaro Galasso
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Circ Res 98:254-61. 2006
    ..GPx-1-deficient mice showed impaired revascularization following hindlimb ischemic surgery based on laser Doppler measurements of blood flow and capillary density in adductor muscle...
  97. ncbi GMP-based CD133(+) cells isolation maintains progenitor angiogenic properties and enhances standardization in cardiovascular cell therapy
    Giuseppe Gaipa
    Laboratorio Interdipartimentale di Terapia Cellulare Stefano Verri, Azienda Ospedaliera San Gerardo, Monza, Milan, Italy
    J Cell Mol Med 14:1619-34. 2010
    ..program was accomplished using in vitro culture assays and in vivo testing in an immunosuppressed mouse model of hindlimb ischemia...
  98. ncbi Inverse dynamics analysis of the pelvic limbs in Labrador Retrievers with and without cranial cruciate ligament disease
    Chantal A Ragetly
    Department of Small Animal Surgery and Small Animal Clinic, University of Illinois, Urbana, IL, USA
    Vet Surg 39:513-22. 2010
    ..To investigate differences in joint mechanics between normal, CCL deficient, and contralateral pelvic limbs...
  99. pmc Gender differences affect blood flow recovery in a mouse model of hindlimb ischemia
    Xinzhi Peng
    Cardiovascular Research Institute, MedStar Health Research Institute, 108 Irving St, NW, Rm 214, Washington, DC 20010, USA
    Am J Physiol Heart Circ Physiol 300:H2027-34. 2011
    ..The aim of this study was to examine gender effects on arteriogenesis and angiogenesis in a mouse ischemic hindlimb model. C57BL/6J mice were subjected to unilateral hindlimb ischemia...
  100. ncbi Morphological changes in rat hindlimb muscle fibres during recovery from disuse atrophy
    Y Itai
    Jichi Medical School, Physical Education, Tochigi, Japan
    Acta Physiol Scand 181:217-24. 2004
    ..The present study attempted to use HE staining to clarify morphological changes in muscle fibres during recovery from disuse muscle atrophy...
  101. ncbi Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice
    Xun Qi
    Department of Physiology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Eur J Pharmacol 634:121-31. 2010
    ..These results indicate that PLGA-based, sustained local delivery of S1P is a potentially useful therapeutic modality for stimulating post-ischemic angiogenesis...

Research Grants69

  1. Gq-coupled Receptors Inhibit PI 3-kinase/Akt Signaling Pathway
    Richard Z Lin; Fiscal Year: 2012
    ..Aim 3 investigates if ablation of p110alpha or p110beta affects skeletal muscle atrophy caused by hindlimb unloading or muscle regrowth following reambulation...
  2. Enhancing Plasticity in Damaged Spinal Cord to Repair Transmission and Function
    Victor L Arvanian; Fiscal Year: 2013
    ..on (1) strengthening synaptic connections through the injury epicenter to lumbar motoneurons, and then to hindlimb muscles (electrophysiology);(2) anatomical plasticity of fibers accounting for the persistence of the synaptic ..
  3. Mechanisms Involved in Age-Related Loss of Muscle Mass and Growth Response
    SUE CAROL BODINE; Fiscal Year: 2012
    ..e., hindlimb reloading following tail suspension unloading, to study the effect of age on both skeletal muscle atrophy and the ..
  4. Effects of Metabolic Disorders on Bone Marrow-Derived Cell Function
    Gina C Schatteman; Fiscal Year: 2012
    ..The effects of the loss of these factors on BMDC induced vascular growth will be studied in the ischemic hindlimb and skin wound models in Leprdb mice and chimeric Leprdb mice whose bone marrow has been replaced with cells from ..
  5. Mitochondrial Modulation of Endothelia Function
    John F Keaney; Fiscal Year: 2013
    ..Since our data indicate global UCP2-null mice have impaired angiogenesis with the stress of hindlimb ischemia, we will determine the specific role of UCP2 for endothelial stress in vivo...
  6. Copper transport protein and inflammatory angiogenesis
    Masuko Ushio-Fukai; Fiscal Year: 2013
    ..ROS production, angiogenesis and inflammatory cell recruitment in injured tissues in a Cu-dependent manner using hindlimb ischemia model with Atox1-/- mice...
  7. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2013
    ..The biomechanics of locomotion are better defined in cats and cats have a hindlimb gait that is close to human than is the rat...
  8. Anti-CD47 mAb Therapy to Improve Kidney Transplantation
    PAMELA ANN TOY-MANNING; Fiscal Year: 2011
    ..tissue perfusion in a number of surgical ischemia models and substantial protection in models of liver and hindlimb IRI...
  9. CYTOLOGICAL STUDIES OF DEVELOPING AND MATURE NEURONS
    Mary Bartlett Bunge; Fiscal Year: 2013
    ..tissue from secondary damage, promote axonal regeneration across the injury, provide myelin and modestly improve hindlimb movements (Bunge 2008, Fortun et al 2009a)...
  10. Central Nervous System Mechanisms of Obesity Hypertension
    Sean D Stocker; Fiscal Year: 2012
    ..from both clinical studies and animal models demonstrates that elevated sympathetic outflow to the kidney and hindlimb vasculature plays a pivotal role in the pathogenesis of obesity-induced hypertension...
  11. TISSUE SPECIFIC REGULATION OF GLUCOSE METABOLISM AND INSULIN ACTION IN IUGR FETUS
    Stephanie R Thorn; Fiscal Year: 2013
    ..Specifically, I will acquire surgical skills for fetal hepatic and hindlimb catheter preparations and develop new tracer methodologies for measurement of glucose and lactate metabolism in ..
  12. E2F1 in Cardiac Neovascularization
    Gangjian Qin; Fiscal Year: 2013
    ..We have recently reported the following: A) Loss of E2F1 enhances angiogenesis in surgically induced hindlimb ischemia and accelerates the recovery of blood flow, indicating that E2F1 is an angiogenic inhibitor;B) The ..
  13. Augmented Phenylalanine Clearance by Muscles as Novel Therapy for Phenylketonuria
    Cary O Harding; Fiscal Year: 2013
    ..delivered by hydrodynamic limb vein injection to induce expression of a Phe metabolizing system directly in hindlimb muscles of Pahenu2 mice...
  14. Nano-sized Cell Guidance System for Ischemic Tissue Repair
    Hyunjoon Kong; Fiscal Year: 2010
    ..demonstrate the function of bioactive poly(glycerol) in vivo using the immunodeficient mouse with an ischemic hindlimb (Aim 3)...
  15. Protection of Mice From Lethal Alphavirus Encephalitis
    David N Irani; Fiscal Year: 2010
    ..In particular, a neuroadapted strain (NSV) induces a highly reproducible disease in susceptible hosts with hindlimb paralysis and death that evolves over a period of 7-10 days...
  16. Redox Regulation of p21ras in Angiogenesis
    Richard A Cohen; Fiscal Year: 2013
    ..Our preliminary studies also indicate that angiogenesis is diminished in the ischemic hindlimb of GRX1 transgenic mice, suggesting the hypothesis that altered GRX1 expression in metabolic disease may inhibit ..
  17. Anti-CD47 mAb Therapy to Improve Kidney Transplantation
    PAMELA ANN TOY-MANNING; Fiscal Year: 2013
    ..with anti-CD47 monoclonal antibodies (CD47mAbs) dramatically improves outcomes in models of kidney, liver, brain, hindlimb and soft tissue IRI...
  18. Gap junctions in Vascular Smooth Muscle: growth control
    Janis M Burt; Fiscal Year: 2013
    ..use of Cx-deficient cell lines, endothelial cells isolated from wild type or Cx37 deficient mice, and an in vivo hindlimb ischemic injury model, asking whether Cx37 works in conjunction with or in opposition to Cx43 to regulate the ..
  19. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2012
    ..data, the hypotheses of this continuation proposal are: (1) that the critical CST activity is produced in the hindlimb area of sensorimotor cortex (SMC) and is guided by the cerebellum;and (2) that reflex conditioning can improve ..
  20. Role of Muscle Connective Tissue in Muscle and Tendon Development
    Gabrielle Kardon; Fiscal Year: 2013
    ..Tbx4, and Tbx5 are key transcription factors that establish the dorsal/ventral, anterior/posterior, and fore/hindlimb asymmetries of the limb and determine the pattern of limb muscles and tendons...
  21. Role of Thromboxane in the Exercise Pressor Reflex in Peripheral Artery Disease
    ANNA KATHERINE LEAL; Fiscal Year: 2013
    ..disease will be elucidated by using thromboxane A2 receptor antagonists to attenuate the circulatory response to hindlimb contraction...
  22. Mechanisms of Neuroinflammation after Fracture
    Wade S Kingery; Fiscal Year: 2013
    ..We have developed a tibia fracture rodent model that closely replicates the CRPS clinical scenario with hindlimb unweighting, allodynia, warmth, edema, bone loss, exaggerated neuroinflammatory responses and increased levels of ..
  23. Profilin-1 phosphorylation in neovascularization
    Yi Fan; Fiscal Year: 2013
    ..mutant in mice demonstrates that Pfn-1 phosphorylation is critical for ischemia-induced neovascularization in the hindlimb. Deficiency in Pfn-1 phosphorylation inhibits EC sprouting in the aorta and wound-induced neovascularization, and ..
  24. Maintenance and Rarefaction of the Native Collateral Circulation
    James E Faber; Fiscal Year: 2013
    ..We have shown that COL extent in murine brain and hindlimb varies widely due to genetic polymorphisms...
  25. Ankle dorsiflexion splinting enhances endothelial function of aged leg muscles
    JUDY M DELP; Fiscal Year: 2013
    ..In Aim 1, blood flow distribution to the lower hindlimb muscles will be evaluated in vivo during acute splinting and immediately following splint removal...
  26. Cortical Control of Hindlimb Muscles in Primates
    PAUL DAVID CHENEY; Fiscal Year: 2012
    ..work in anesthetized macaques and baboons has established some basic features of the synaptic linkage between hindlimb motoneurons and primary motor cortex (M1), including the existence of monosynaptic connections, suggesting a ..
  27. Role of Stem Cells in Skeletal Aging
    Julie Glowacki; Fiscal Year: 2010
    ..of stromal cells because of the clearing of the recipient marrow niche with high dose irradiation only to the hindlimb. Following irradiation and before injection of MSCs, standardized unicortical tibial wounds will be made...
  28. Quantitative evaluation of 3D mouse behaviors in the open field using markerless
    D Michele Basso; Fiscal Year: 2012
    ..2) Relate disease severity to patterns of fore- and hindlimb coordination in the open field...
  29. Metaplasticity and Recovery After Spinal Cord Injury: Cellular Mechanisms
    Adam R Ferguson; Fiscal Year: 2012
    ..Rats with complete spinal cord transections can learn to maintain the hindlimb in a flexed position if leg shock is delivered when the leg is extended (response- contingent shock)...
  30. Nox 4 modulation of NO bioavailability and vascular function
    Siobhan E Craige; Fiscal Year: 2012
    ..phenotypic endothelial responses important for angiogenesis such as proliferation, migration, and recovery from hindlimb ischemia will be examined...
  31. Extracellular matrix hydrogels for treating ischemia
    Karen L Christman; Fiscal Year: 2013
    ..injection of the skeletal muscle matrix enhances the recruitment and proliferation of muscle progenitors in a hindlimb ischemia model. In addition, we show in vitro studies that these materials promote muscle progenitor maturation...
  32. High throughput screening of embryonic stem cell differentiation
    Ngan F Huang; Fiscal Year: 2010
    ..Finally, using an in vivo model of PAD (hindlimb ischemia), I will determine whether ESC-derived ECs can survive in the ischemic limb, incorporate into the ..
  33. Genetic Regulation of Progenitor Cells in Appendicular Skeletal Development
    Yasuhiko Kawakami; Fiscal Year: 2013
    ..protein, prior to limb outgrowth, resulted in the loss of proximal-anterior skeletal elements only in the hindlimb, such as the femur, tibia and anterior digits...
  34. Acute and Chronic Afferent Engagement: Sympathetic and End Organ Responses
    Lawrence I Sinoway; Fiscal Year: 2013
    ..Two models of limb ischemia will be employed: a) PAD in human subjects (Projects 1 and 4);and b) hindlimb arterial occlusion in rats (Projects 2 and 3)};2) conceptual synergy exists between the projects that will lead ..
  35. KLF4 and Transcriptional Control of Neovascularization
    Anne Hamik; Fiscal Year: 2013
    ..In hindlimb ischemia studies endothelial KLF4 overexpression leads to poor blood flow immediately post femoral artery ..
  36. Effects of Advanced EA on Hypertension: Role of nNOS-NO in the Dorsal Medulla
    Sheng Xing Ma; Fiscal Year: 2010
    ..The gracile nucleus and nucleus tractus solitarius (NTS) receive somatosensory afferent inputs from the hindlimb, and low-frequency electroacupuncture (EA) stimulation of hindlimb acupoint ST36 produces long-lasting ..
  37. Role of Cysteine Sulfenic Acid Formation in Compartmentalization of VEGF Signalin
    Masuko Ushio-Fukai; Fiscal Year: 2013
    ..bond formation in human ECs, which was inhibited by a thiol antioxidant, N-acetylcysteine, and confirmed in mice hindlimb ischemia model. We showed that PTP1B negatively regulates VEGF-induced VEGFR2-pY and EC proliferation...
  38. Musculoskeletal Response to Partial Weight Bearing
    Mary L Bouxsein; Fiscal Year: 2010
    ..to partial weight-bearing at 20, 40, and 60% of body weight, as compared to both normal weight-bearing and full hindlimb unloading via tail suspension...
  39. Computer simulations of populations of mammalian motor units
    CHARLES HECKMAN; Fiscal Year: 2013
    ..We focus on hindlimb extensors in the cat, for which the most complete experimental database is available...
  40. A role for the miroRNA miR-133b in synapse development
    MARY PATRICIA HEYER; Fiscal Year: 2010
    ..enrichment of miR-133b, while neural regulation will be explored by miRNA northern blot following denervation of hindlimb muscle. The second aim will determine whether miR-133b is critical for NMJ formation...
  41. Nutrition Infection and Hepatic Carbohydrate Metabolism
    Owen P McGuinness; Fiscal Year: 2013
    ..Hepatic glucose metabolism (unidirectional hepatic glucose uptake and production, glucose oxidation) and hindlimb will be assessed using a combination of tracer and arterio-venous difference techniques...
  42. Nutrition Infection and Hepatic Carbohydrate Metabolism
    Owen McGuinness; Fiscal Year: 2009
    ..Hepatic glucose metabolism (unidirectional hepatic glucose uptake and production, glucose oxidation) and hindlimb will be assessed using a combination of tracer and arterio-venous difference techniques...
  43. Load-Driven Bone Lengthening
    Ping Zhang; Fiscal Year: 2010
    ..In order to examine the above hypotheses, three specific aims are proposed using a hindlimb of C57BL/6 mice as a model system...
  44. Functional architecture of motor cortex: Topography and connections
    DYLAN FRANCIS COOKE; Fiscal Year: 2011
    ..Motor cortex in mammals is organized in a rough somatotopic pattern, with the muscles of the hindlimb represented medially and the muscles of the forelimb and face represented progressively more laterally...
  45. Defining the role of satellite cells in muscle maintenance throughout the lifespa
    Charlotte A Peterson; Fiscal Year: 2010
    ..dynamics with muscle hypertrophy induced by synergist ablation and re-growth following muscle atrophy induced by hindlimb unloading...
  46. Cyclic compressive loading to negate atrophy and impaired regrowth in aged muscle
    Esther E Dupont-Versteegden; Fiscal Year: 2013
    ..Rats at 10 and 30 months of age will be hindlimb suspended for 14 days followed by ambulation for 1, 2, 4 or 14 days...
  47. Mechanisms of Collateral Development and Collateral Growth in Ischemia
    James E Faber; Fiscal Year: 2011
    ..Our preliminary results in the mouse hindlimb model suggest VEGF is a critical determinant of COL remodeling in ischemia...
  48. CORTICAL CONTROL OF MOVEMENT
    Asaf Keller; Fiscal Year: 2010
    ..including humans, contains a gross somatotopic representation of the major divisions of the body, such as hindlimb, forelimb, and face...
  49. Limb-type specific distinct upstream regulation of a common Hand2-Shh pathway
    Yasuhiko Kawakami; Fiscal Year: 2013
    ..questions by elucidating the mechanisms of spatial activation of the Sonic hedgehog (Shh) gene specifically in hindlimb buds...
  50. Influence of alpha-2 agonists on reflex pathways and limb stiffness
    Mark A Lyle; Fiscal Year: 2013
    ..identify the distribution, strength, and time course of intermuscular reflex networks linking major hindlimb muscle groups (Aim 1)...
  51. REGULATION OF SKELETAL MUSCLE METABOLISM
    Leonard S Jefferson; Fiscal Year: 2013
    ..we will pursue an experimental protocol in which control rats and rats subjected to short-term unilateral hindlimb immobilization will be placed on a meal-feeding regimen designed to elicit the anabolic resistance of protein ..
  52. INTERSTITIAL FLUID FLOW IN BONE REMODELING
    John A Frangos; Fiscal Year: 2012
    ..determine if oscillatory flow induces an anabolic response, while increased steady flow is anti-resorptive in the hindlimb suspended rat...
  53. Activity-dependent functional regeneration after SCI and OEC transplantation
    PATRICIA EMORY PHELPS; Fiscal Year: 2013
    ..This proposal asks if the OEC effect on hindlimb motor function can be enhanced in both magnitude and specificity with different activity- based interventions...
  54. Mesenchymal stem cells in the treatment of hindlimb ischemia in diabetic mice
    LOUIS MICHAEL MESSINA; Fiscal Year: 2013
    ..a WT host, diabetic MSC impair post-ischemic neovascularization and generate fatty infiltration in the ischemic hindlimb. The project hypothesis is that oxidant stress in diabetic MSC restricts their pluripotency and hence their ..
  55. Mechanisms Underlying Rhythm Generation in Identified Spinal Interneurons in Mice
    Lea Ziskind Conhaim; Fiscal Year: 2010
    ..The integrated activity of these neuronal populations produces rhythmic excitation of motoneurons during hindlimb movements in walking vertebrates...
  56. Role of Ectodermal Signals in Limb Bud Outgrowth and Development
    Trevor J Williams; Fiscal Year: 2010
    ..these molecular changes are that limb formation is induced along the entire lateral axis between the forelimb and hindlimb buds...
  57. Adaptations to robotic resistance during treadmill training in SCI rats
    Ray D de Leon; Fiscal Year: 2013
    ..of resistive forces that target specific movements and determine which force corrects movement trajectory and hindlimb muscle EMG activity...
  58. Molecular mechanisms of Shiga toxin action in the mammal central nervous system
    Fumiko Obata; Fiscal Year: 2011
    ..I propose to reveal the mechanisms of Shiga toxin action in the CNS by using in vitro neuron-astrocytic cell culture and in vivo with the Stx2 induced hindlimb paralysis murine model.
  59. Basal Ganglia Circuitry and Molecules in Pathogenesis of Motor Stereotypy
    Xiangdong William Yang; Fiscal Year: 2010
    ..by the Zfp521cko mice, which include facial/head grooming with the forelimbs, body licking, rapid flapping of one hindlimb, and rapid head twitches, are highly frequent, debilitating, cause self-injurious lesions, and impair an ..
  60. Hybrid Imaging of Angiogenesis and Arteriogenesis
    Albert Sinusas; Fiscal Year: 2009
    ..mediating hypoxia- induced angiogenesis and flow-induced arteriogenesis using well established murine models of hindlimb ischemia...
  61. Neuronal Modulation of Focal Bone Homeostasis
    Ted S Gross; Fiscal Year: 2013
    ..Our preliminary data with a mouse hindlimb specific defect in proprioception has led us to hypothesize that trabecular bone homeostasis is modulated by ..
  62. Intersection of TGF-b and SOST in the Regulation of Load-induced Bone Formation
    Jacqueline Nguyen; Fiscal Year: 2013
    ..We will evaluate TGF[unreadable] signaling in a hindlimb loading model, a gain-of-function approach, and TGF[unreadable] response to unloading with a disuse model in the ..
  63. MASSAGE THERAPY FOR EXPERIMENTAL LYMPHEDEMA
    Marlys Witte; Fiscal Year: 2002
    ..Unilateral hindlimb LE is produced in Wistar-fuzzy rats by unilateral surgery + radiation (consisting of sequential operative ..
  64. Somatosensory feedback controlling a neuroprosthesis
    Douglas J Weber; Fiscal Year: 2010
    ..Using a decerebate cat preparation, the following state variables for the hindlimb will be studied: position, velocity, acceleration, endpoint force (e.g...
  65. GENETIC CONTROL OF NEUROMUSCULAR DEGENERATION IN MICE
    Gregory Cox; Fiscal Year: 2002
    ..Neuromuscular degeneration, nmd, is an autosomal recessive mouse mutant characterized by severe hindlimb muscle atrophy due to progressive degeneration of spinal motor neurons...
  66. CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RAT
    J Cunningham; Fiscal Year: 2005
    ..Additionally, these data may contribute to understanding of health problems associated with an aging population and with cardiovascular disease such as congestive heart failure. ..
  67. Opioid-Mediated Fas Expression in Lymphocyte Apoptosis
    Yufang Shi; Fiscal Year: 2005
    ..Simulation of these factors with ground animal models (e.g., hindlimb suspension in rodents) has been used to replicate the effects of space flight on immune system...
  68. Treatment of Transplant Reperfusion with an Anti-CD47 Antibody
    PAMELA TOY MANNING; Fiscal Year: 2009
    ..in enhanced tissue perfusion in a number of surgical ischemia models and protection from IRI in both liver and hindlimb models...
  69. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..Presently, little is known about how the integrative biological response to decreased mechanical loading [hindlimb non-weight bearing (NWB)] leads to fiber-type shifts and altered transcriptional regulation of MyHC genes...