wing

Summary

Top Publications

  1. ncbi hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    Shian Wu
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 114:445-56. 2003
  2. ncbi Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways
    Hyung Don Ryoo
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 252, New York, NY 10021, USA
    Dev Cell 7:491-501. 2004
  3. doi Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila
    Benoit Aigouy
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
    Cell 142:773-86. 2010
  4. ncbi The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    Kieran F Harvey
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Cell 114:457-67. 2003
  5. ncbi Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
    T Usui
    Department of Biophysics, Faculty of Science, Japan
    Cell 98:585-95. 1999
  6. doi The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway
    Shian Wu
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 14:388-98. 2008
  7. pmc Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand
    Arnaud Martin
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 109:12632-7. 2012
  8. doi SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila
    Youlian Goulev
    Department of Developmental Biology, Unite Mixte de Recherche 7592, Universite Paris 7 Denis Diderot, Tour 43 2, place Jussieu, F 75251 Paris Cedex 05, France
    Curr Biol 18:435-41. 2008
  9. pmc Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics, and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Dev Cell 20:511-25. 2011
  10. doi Negative correlation between Nosema ceranae spore loads and deformed wing virus infection levels in adult honey bee workers
    Cecilia Costa
    Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Unità di Ricerca di Apicoltura e Bachicoltura, Via di Saliceto 80, 40128 Bologna, Italy
    J Invertebr Pathol 108:224-5. 2011

Research Grants

  1. INTERNET ENHANCED HEALTH PROMOTION FOR OBESE ETHNIC MINORITY ADOLESCENTS
    Jessica A Whiteley; Fiscal Year: 2011
  2. Erika Litvin Bloom; Fiscal Year: 2016
  3. Kathryn E Demos; Fiscal Year: 2015
  4. Renovation and Infrastructure Upgrade of Laboratory Research Wing at Johns Hopkin
    Michael J Klag; Fiscal Year: 2010
  5. Suppression of tadpole limbs: a model for organ size regulation
    RICHARD ELINSON; Fiscal Year: 2009
  6. Planar Cell Polarity and the Cytoskeleton
    Andreas Jenny; Fiscal Year: 2013
  7. Udai B Pandey; Fiscal Year: 2016
  8. Andreas Bergmann; Fiscal Year: 2016
  9. Jason Lillis; Fiscal Year: 2016
  10. Mapping and rescuing EMS-induced lethal mutations on the Drosophila X Chromosome
    Hugo J Bellen; Fiscal Year: 2010

Detail Information

Publications368 found, 100 shown here

  1. ncbi hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    Shian Wu
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 114:445-56. 2003
    ..A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals...
  2. ncbi Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways
    Hyung Don Ryoo
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 252, New York, NY 10021, USA
    Dev Cell 7:491-501. 2004
    ..These findings support a model where apoptotic cells activate signaling cascades for compensatory proliferation...
  3. doi Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila
    Benoit Aigouy
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
    Cell 142:773-86. 2010
    ..The mechanisms that globally orient planar polarity are not understood, and are investigated here in the Drosophila wing using a combination of experiment and theory...
  4. ncbi The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    Kieran F Harvey
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Cell 114:457-67. 2003
    ..Hpo, Sav, and Wts interact physically and functionally, and regulate DIAP1 levels, likely by Hpo-mediated phosphorylation and subsequent degradation. Thus, Hpo links Sav and Wts to a key regulator of apoptosis...
  5. ncbi Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
    T Usui
    Department of Biophysics, Faculty of Science, Japan
    Cell 98:585-95. 1999
    ..of the cadherin superfamily, designated Flamingo (Fmi), localized at cell-cell boundaries in the Drosophila wing. In the absence of Fmi, planar polarity was distorted...
  6. doi The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway
    Shian Wu
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 14:388-98. 2008
    ..Our results uncover a heretofore missing link in the Hpo signaling pathway and provide a glimpse of the molecular events on a Hpo-responsive enhancer element...
  7. pmc Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand
    Arnaud Martin
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 109:12632-7. 2012
    ..of the extensive diversity of Heliconius butterflies to identify a gene that causes adaptive variation of black wing patterns within and between species...
  8. doi SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila
    Youlian Goulev
    Department of Developmental Biology, Unite Mixte de Recherche 7592, Universite Paris 7 Denis Diderot, Tour 43 2, place Jussieu, F 75251 Paris Cedex 05, France
    Curr Biol 18:435-41. 2008
    ..interacts with the product of the vestigial (vg) gene, where the dimer functions as a master gene controlling wing formation [3, 4]...
  9. pmc Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics, and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Dev Cell 20:511-25. 2011
    ..Thus, we define the distinct roles of specific core proteins in the formation of asymmetric contacts between cells, which is a key event in the generation of coordinated cellular asymmetry...
  10. doi Negative correlation between Nosema ceranae spore loads and deformed wing virus infection levels in adult honey bee workers
    Cecilia Costa
    Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Unità di Ricerca di Apicoltura e Bachicoltura, Via di Saliceto 80, 40128 Bologna, Italy
    J Invertebr Pathol 108:224-5. 2011
    ..Here we investigated if there is an association between the microsporidian Nosema ceranae and the deformed wing virus (DWV) in different body sections of individual honey bee workers (Apis mellifera ligustica) under exclusion ..
  11. ncbi Lipoprotein particles are required for Hedgehog and Wingless signalling
    Daniela Panàkovà
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nature 435:58-65. 2005
    ..proteins copurify with lipoprotein particles, and co-localize with them in the developing wing epithelium of Drosophila...
  12. doi optix drives the repeated convergent evolution of butterfly wing pattern mimicry
    Robert D Reed
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Science 333:1137-41. 2011
    ..Here, we characterize one of the major genes responsible for mimetic wing pattern evolution in Heliconius butterflies...
  13. ncbi A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster
    D Gubb
    J Embryol Exp Morphol 68:37-57. 1982
    ..In the wing, polarity formation is largely cell autonomous and is independent of the anteroposterior compartment boundary...
  14. ncbi Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
    Ryan S Udan
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Cell Biol 5:914-20. 2003
    ..We find that Sav binds to a regulatory domain of Hpo that is essential for its function, indicating that Hpo acts together with Sav and Wts in a signalling module that coordinately regulates cell proliferation and apoptosis...
  15. ncbi Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role
    Jun R Huh
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Curr Biol 14:1262-6. 2004
    ..For example, at least 40%-60% of cells in the Drosophila wing disc can be lost, yet these discs go on to give rise to normal-looking adult wings as a result of compensatory ..
  16. ncbi Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila
    Ainhoa Pérez-Garijo
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Development 131:5591-8. 2004
    ..In the Drosophila wing imaginal disc there is little apoptosis in normal development but X-rays can induce high apoptotic levels, which ..
  17. ncbi A draft sequence for the genome of the domesticated silkworm (Bombyx mori)
    Qingyou Xia
    Southwest Agricultural University, Chongqing Beibei, 400716, China
    Science 306:1937-40. 2004
    ..Our estimated gene count is 18,510, which exceeds the 13,379 genes reported for Drosophila melanogaster. Comparative analyses to fruitfly, mosquito, spider, and butterfly reveal both similarities and differences in gene content...
  18. ncbi Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium
    Yuko Shimada
    Laboratory of Cell Recognition and Pattern Formation, Graduate School of Biostudies, South Campus Research Building Building G, Room 118, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Dev Cell 10:209-22. 2006
    ..Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive ..
  19. pmc A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth
    Myriam Zecca
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA
    PLoS Biol 8:e1000386. 2010
    During development, the Drosophila wing primordium undergoes a dramatic increase in cell number and mass under the control of the long-range morphogens Wingless (Wg, a Wnt) and Decapentaplegic (Dpp, a BMP)...
  20. pmc Dissecting the mechanisms of Notch induced hyperplasia
    Alexandre Djiane
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    EMBO J 32:60-71. 2013
    ..Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation...
  21. ncbi Pattern formation and eyespot determination in butterfly wings
    S B Carroll
    Howard Hughes Medical Institute, Madison, WI
    Science 265:109-14. 1994
    ..Butterfly wing patterns are organized by two spatial coordinate systems...
  22. doi Wing development genes of the pea aphid and differential gene expression between winged and unwinged morphs
    J A Brisson
    University of Southern California, Los Angeles, USA
    Insect Mol Biol 19:63-73. 2010
    Little is known about when, how or even if the wing development gene network elucidated in Drosophila is deployed in direct-developing insects...
  23. ncbi Direct and long-range action of a wingless morphogen gradient
    M Zecca
    Zoologisches Institut der Universitat Zurich, Switzerland
    Cell 87:833-44. 1996
    ..We interpret these findings as evidence that Wg can act directly and at long range as a gradient morphogen during normal development...
  24. ncbi Drosophila myc regulates cellular growth during development
    L A Johnston
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington 98109, USA
    Cell 98:779-90. 1999
    ..Here we address the functions of Drosophila Myc (dMyc) during development. Using mosaic analysis in the fly wing, we show that loss of dMyc retards cellular growth (accumulation of cell mass) and reduces cell size, whereas dMyc ..
  25. ncbi Rapid evolution of a geographic cline in size in an introduced fly
    R B Huey
    Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Science 287:308-9. 2000
    ..In ancestral Old World populations, wing length increases clinally with latitude...
  26. ncbi Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling
    David R P Tree
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305, USA
    Cell 109:371-81. 2002
    ..From initial, symmetric subcellular distributions in pupal wing cells, Frizzled and Dishevelled become highly enriched at the distal portion of the cell cortex...
  27. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
    ..distal gradient of the protocadherin Dachsous (Ds) acts as a cue for planar cell polarity (PCP) in the Drosophila wing, orienting cell-cell interactions by inhibiting the activity of the protocadherin Fat (Ft)...
  28. doi Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
    Beatriz García Fernández
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, P 2780 156 Oeiras, Portugal
    Development 138:2337-46. 2011
    ..Taken together, these findings indicate a novel interplay between Hippo pathway activity and actin filament dynamics that is essential for normal growth control...
  29. pmc Modulating F-actin organization induces organ growth by affecting the Hippo pathway
    Leticia Sansores-Garcia
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    EMBO J 30:2325-35. 2011
    ..Thus, regulators of F-actin, and in particular Capping proteins, are essential for proper growth control by affecting Hippo signalling...
  30. ncbi HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient
    Antonio J Giraldez
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Dev Cell 2:667-76. 2002
    ..High levels of Wingless signaling induce Notum expression. Thus, Wingless contributes to shaping its own gradient by regulating expression of a protein that modifies its interaction with cell surface proteoglycans...
  31. doi The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc
    Ainhoa Pérez-Garijo
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Development 136:1169-77. 2009
    ..We propose that the compensatory growth is simply a homeostatic response of wing compartments, which resume growth after massive cellular loss until they reach the final correct size...
  32. pmc Tissue homeostasis in the wing disc of Drosophila melanogaster: immediate response to massive damage during development
    Salvador C Herrera
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    PLoS Genet 9:e1003446. 2013
    ..We are using the Drosophila melanogaster wing imaginal disc to study the response to major damage inflicted during development...
  33. ncbi Control of compartment development by the engrailed gene in Drosophila
    G Morata
    Nature 255:614-7. 1975
  34. ncbi Specification of the wing by localized expression of wingless protein
    M Ng
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 381:316-8. 1996
    ..AP subdivision of the disc primordia is inherited from the embryonic ectoderm. DV subdivision of the wing disc occurs during the second larval instar through localized expression of the apterous protein (Apterous) in ..
  35. ncbi Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 122:2719-28. 1996
    ..comparison between the phenotypes produced by Notch, Suppressor of Hairless and Enhancer of split mutations in the wing and thorax indicate that Suppressor of Hairless and Notch requirements are indistinguishable, but that Enhancer of ..
  36. ncbi Dual roles for patched in sequestering and transducing Hedgehog
    Y Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 87:553-63. 1996
    ..Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement...
  37. ncbi Distinct roles for the actin and microtubule cytoskeletons in the morphogenesis of epidermal hairs during wing development in Drosophila
    C M Turner
    Biology Department and Cancer Center, University of Virginia, Charlottesville 22903, USA
    Mech Dev 70:181-92. 1998
    ..cytoskeletons have overlapping, but distinct roles in the morphogenesis of epidermal hairs during Drosophila wing development...
  38. ncbi Mathematical modeling of planar cell polarity to understand domineering nonautonomy
    Keith Amonlirdviman
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Science 307:423-6. 2005
    ..modeling and simulation to fully reproduce PCP phenotypes, including domineering nonautonomy, in the Drosophila wing. The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-..
  39. doi Deformed wing virus
    Joachim R de Miranda
    Department of Ecology, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden
    J Invertebr Pathol 103:S48-61. 2010
    Deformed wing virus (DWV; Iflaviridae) is one of many viruses infecting honeybees and one of the most heavily investigated due to its close association with honeybee colony collapse induced by Varroadestructor. In the absence of V...
  40. pmc Live imaging of Drosophila imaginal disc development
    Silvia Aldaz
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 107:14217-22. 2010
    ..As a proof of principle, we have analyzed the transformation that occurs during metamorphosis of the wing imaginal disc into the mature wing and report several previously unobserved stages of this model of organogenesis...
  41. doi Evaluating the life-history trade-off between dispersal capability and reproduction in wing dimorphic insects: a meta-analysis
    Patrick A Guerra
    Department of Biology, McGill University, Montreal, QC, Canada
    Biol Rev Camb Philos Soc 86:813-35. 2011
    A life-history trade-off exists between flight capability and reproduction in many wing dimorphic insects: a long-winged morph is flight-capable at the expense of reproduction, while a short-winged morph cannot fly, is less mobile, but ..
  42. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
    Notch function is required at the dorsoventral boundary of the developing Drosophila wing for its normal growth and patterning...
  43. ncbi The wingless signalling pathway and the patterning of the wing margin in Drosophila
    J P Couso
    Department of Zoology, University of Cambridge, UK
    Development 120:621-36. 1994
    The margin of the wing of Drosophila is defined and patterned from a stripe of cells expressing the wingless (wg) gene that is established during the third larval instar in the developing wing blade...
  44. pmc Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells
    L L Wong
    Biology Department, University of Virginia, Charlottesville 22901
    J Cell Biol 123:209-21. 1993
    The Drosophila wing is decorated with a regular array of distally pointing hairs. In the pupal wing, the hairs are formed from micro-villus like prehairs that contain large bundles of actin filaments...
  45. pmc Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
    D C Goberdhan
    Research School of Biosciences, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Genes Dev 13:3244-58. 1999
    ..It acts in opposition to Dp110 to control cell number and growth, while coordinately influencing events at the cell periphery via its effects on the actin cytoskeleton...
  46. ncbi Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing
    D I Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN, Sheffield, United Kingdom
    Mol Cell 7:367-75. 2001
    ..In the wing, a single trichome is produced by each cell, which normally points distally...
  47. ncbi Trimeric G protein-dependent frizzled signaling in Drosophila
    Vladimir L Katanaev
    Department of Genetics and Development, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 701 West 168 Street, New York, NY 10032, USA
    Cell 120:111-22. 2005
    ..Thus, Go is likely part of a trimeric G protein complex that directly transduces Fz signals from the membrane to downstream components...
  48. pmc Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes
    Michele Markstein
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 40:476-83. 2008
    ..The generality of our approach makes it adaptable to other model systems to identify and modify loci for optimal transgene expression...
  49. doi Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary
    Katharina P Landsberg
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Biol 19:1950-5. 2009
    ..Our results provide a physical mechanism in which the local increase in Myosin II-dependent cell bond tension directs cell sorting at compartment boundaries...
  50. pmc Wing pathology of white-nose syndrome in bats suggests life-threatening disruption of physiology
    Paul M Cryan
    United States Geological Survey, Fort Collins Science Center, Fort Collins, CO 80526, USA
    BMC Biol 8:135. 2010
    ..destructans and propose that mortality is caused by catastrophic disruption of wing-dependent physiological functions. Mechanisms of disease associated with G...
  51. pmc Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila
    Yanlan Mao
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 25:131-6. 2011
    ..This phenomenon is evident in the developing Drosophila wing epithelium, where the tissue becomes elongated along the proximal-distal axis...
  52. pmc Genomic consequences of background effects on scalloped mutant expressivity in the wing of Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 181:1065-76. 2009
    ....
  53. ncbi Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
    J Kim
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, 53706, USA
    Nature 382:133-8. 1996
    ..The Drosophila vestigial gene is selectively required for wing-cell proliferation, and is sufficient to induce outgrowths of wing tissue from eyes, legs and antennae...
  54. ncbi Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    J Jiang
    Howard Hughes Medical Institute, Department of Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 391:493-6. 1998
    ....
  55. ncbi Fidelity in planar cell polarity signalling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nature 421:543-7. 2003
    The polarity of Drosophila wing hairs displays remarkable fidelity. Each of the approximately 30,000 wing epithelial cells constructs an actin-rich prehair that protrudes from its distal vertex and points distally...
  56. ncbi Cell interactions and planar polarity in the abdominal epidermis of Drosophila
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 131:4651-64. 2004
    ..Recently, it has been shown that, for a limited period shortly before hair outgrowth in the wing, the four proteins we study, as well as others, become asymmetrically localised in the cell membrane, and this ..
  57. ncbi Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing
    MICHAEL B O'CONNOR
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Development 133:183-93. 2006
    ..Likewise, during pupal wing development, BMPs help to specify vein versus intervein cell fate...
  58. doi Deformed wing virus: replication and viral load in mites (Varroa destructor)
    Sebastian Gisder
    Institute for Bee Research, Hohen Neuendorf, Germany
    J Gen Virol 90:463-7. 2009
    Deformed wing virus (DWV) normally causes covert infections but can have devastating effects on bees by inducing morphological deformity or even death when transmitted by the ectoparasitic mite Varroa destructor...
  59. ncbi Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
    T Adachi-Yamada
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan Science and Technology Corporation
    Nature 400:166-9. 1999
    ..Here we show that either decreased Dpp signalling in the distal wing cells or increased Dpp signalling in the proximal wing cells causes apoptosis...
  60. ncbi Butterfly wing pattern evolution is associated with changes in a Notch/Distal-less temporal pattern formation process
    Robert D Reed
    Department of Molecular and Cellular Biology, University of Arizona, 1007 E Lowell Street, Tucson, AZ 85721 USA
    Curr Biol 14:1159-66. 2004
    In butterflies there is a class of "intervein" wing patterns that have lines of symmetry halfway between wing veins...
  61. ncbi Ectopic gene expression and homeotic transformations in arthropods using recombinant Sindbis viruses
    D L Lewis
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, University of Wisconsin, Madison, 53706, USA
    Curr Biol 9:1279-87. 1999
    ..Direct analysis of how a particular gene functions in a given species during development is hindered by the lack of broadly applicable techniques for manipulating gene expression...
  62. ncbi Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression
    Michael A Simon
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Development 131:6175-84. 2004
    ..In contrast to the eye, the endogenous gradients of Fj and Ds expression do not play a major role in directing PCP in the wing. Thus, this study reveals that the two tissues use different strategies to orient their PCP.
  63. ncbi Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog
    Bruno Glise
    Centre de Biologie du Developpement, UMR 5547 and IFR 109 CNRS UPS, 118 route de Narbonne, 31062 Toulouse Cedex 4, France
    Dev Cell 8:255-66. 2005
    ..Shifted is required for high levels of long-range signaling in the developing wing imaginal disc...
  64. pmc Morphogen control of wing growth through the Fat signaling pathway
    Dragana Rogulja
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Cell 15:309-21. 2008
    ..We show that the Dpp morphogen gradient in the Drosophila wing influences growth by modulating the activity of the Fat signaling pathway...
  65. pmc Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium
    Ainhoa Callejo
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 108:12591-8. 2011
    ..the mechanism of Hh release from the producing cells to form a morphogenetic gradient in the Drosophila wing imaginal disk epithelium...
  66. doi Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing
    Isabelle Becam
    Institute for Research in Biomedicine IRB Barcelona, Parc Cientific de Barcelona, Baldiri Reixac, 10 12, 08028 Barcelona, Spain
    Development 138:3781-9. 2011
    ..Here, we present evidence that Notch mediates boundary formation in the Drosophila wing in part through repression of bantam miRNA...
  67. pmc Population structure of Bactrocera dorsalis s.s., B. papayae and B. philippinensis (Diptera: Tephritidae) in southeast Asia: evidence for a single species hypothesis using mitochondrial DNA and wing-shape data
    Mark K Schutze
    CRC for National Plant Biosecurity, LPO Box 5012, Bruce 2617, A C T, Australia
    BMC Evol Biol 12:130. 2012
    ..This study analysed population structure of these three species within a southeast Asian biogeographical context to assess potential dispersal patterns and the validity of their current taxonomic status...
  68. ncbi Nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wing
    M Ng
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:589-99. 1995
    The nubbin gene is required for normal growth and patterning of the wing in Drosophila. We report here that nubbin encodes a member of the POU family of transcription factors...
  69. ncbi The generation and diversification of butterfly eyespot color patterns
    C R Brunetti
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, USA
    Curr Biol 11:1578-85. 2001
    ..Foci are the proposed source of a morphogen, the levels of which determine the color of surrounding wing scale cells...
  70. pmc Comparative insights into questions of lepidopteran wing pattern homology
    Antonia Monteiro
    Department of Biological Sciences, University at Buffalo, 109 Cooke Hall, Buffalo, NY 14260, USA
    BMC Dev Biol 6:52. 2006
    ..involving multiple concentric rings of colored scales, but usually occurring in non-homologous positions on the wing. Within the butterflies, on the other hand, spots that share the same homologous position may not share the ..
  71. doi A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network
    Abil Saj
    Department of Biosystems Science and Engineering, ETHZ, 4058 Basel, Switzerland
    Dev Cell 18:862-76. 2010
    ..Our study reveals a hitherto unappreciated diversity of tissue-specific modulators impinging on Notch and opens new avenues for studying Notch regulation and function in development and disease...
  72. pmc Essential role of Duox in stabilization of Drosophila wing
    Nguyen Thi Tu Anh
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Biol Chem 286:33244-51. 2011
    ..and en-GAL4> UAS-dDuoxIR(370-518), in which dDuox was knocked down selectively in the posterior area of the wing disc, the posterior compartment of the adult wings became paler and more fragile with wing veins that were ..
  73. doi Convergent, modular expression of ebony and tan in the mimetic wing patterns of Heliconius butterflies
    Laura C Ferguson
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, UK CB2 3EJ
    Dev Genes Evol 221:297-308. 2011
    ..Here, we study insect melanin synthesis genes in Heliconius butterflies, a group characterised by its diversity of wing patterns consisting of black (melanin), and yellow and red (ommochrome) pigmented scales...
  74. pmc Artificially induced changes of butterfly wing colour patterns: dynamic signal interactions in eyespot development
    Joji M Otaki
    The BCPH Unit of Molecular Physiology, Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
    Sci Rep 1:111. 2011
    ..These results demonstrate limitations of the conventional gradient model and support a dynamic interactive nature of morphogenic signals for colour-pattern determination in butterfly wings...
  75. ncbi Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    T Tabata
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Cell 76:89-102. 1994
    ..hedgehog ectopically, or of a mutant that expresses hedgehog abnormally in the anterior compartment of the wing disc, indicates that hedgehog is involved in regulating patched...
  76. ncbi Kinetics of morphogen gradient formation
    Anna Kicheva
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, 01307 Dresden, Germany
    Science 315:521-5. 2007
    In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg...
  77. ncbi Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 133:2315-24. 2006
    ..Finally, we show that ft mutants or a dominant-negative Ft construct can affect disc growth without changes in the expression of wingless and Wingless target genes...
  78. pmc On the mechanism of wing size determination in fly development
    Lars Hufnagel
    Kavli Institute for Theoretical Physics, Kohn Hall, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 104:3835-40. 2007
    ..Here, we present evidence that the decapentaplegic (Dpp) morphogen distribution in the developing Drosophila wing imaginal disk does not adapt to disk size...
  79. doi Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1
    Thomas J Widmann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    J Cell Sci 122:1362-73. 2009
    ..activity correlates with the transition from cuboidal to columnar cell shape in developing Drosophila melanogaster wing disc epithelia...
  80. doi Cell death-induced regeneration in wing imaginal discs requires JNK signalling
    Cora Bergantiños
    Departament de Genetica, Facultat de Biologia, and Institut de Biomedicina de la Universitat de Barcelona IBUB, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Development 137:1169-79. 2010
    ..Using a ptc-Gal4 construct to drive rpr expression in the wing disc resulted in a stripe of dead cells in the anterior compartment flanking the anteroposterior boundary, whereas ..
  81. pmc Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity
    Toshiyuki Harumoto
    Graduate School of Biostudies, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8507, Japan
    Dev Cell 19:389-401. 2010
    ..In the Drosophila wing, which develops PCP along its proximal-distal (P-D) axis, we previously proposed that the core PCP mediator ..
  82. pmc Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors
    Gongping Sun
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Biol 350:139-51. 2011
    ..Here we show that induction of apoptosis in the Drosophila wing imaginal disc stimulates activation of the Hippo pathway transcription factor Yorkie in surviving and nearby cells, ..
  83. doi Dynamics of Dpp signaling and proliferation control
    O Wartlick
    Department of Biochemistry, Faculty of Sciences, Geneva University, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland
    Science 331:1154-9. 2011
    ..mechanism of proliferation control by the Dpp gradient, we quantified Dpp concentration and signaling levels during wing disc growth. Both Dpp concentration and signaling gradients scale with tissue size during development...
  84. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  85. pmc Polymorphic butterfly reveals the missing link in ecological speciation
    Nicola L Chamberlain
    Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Science 326:847-50. 2009
    ..experiments, field observations, and population genetics, we studied a butterfly population with a mimetic wing color polymorphism and found that the butterflies exhibited partial, color-based, assortative mate preference...
  86. ncbi Interaction between Wingless and Notch signaling pathways mediated by dishevelled
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 271:1826-32. 1996
    ..It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways...
  87. ncbi Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
    X Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235 9040, USA
    Dev Biol 221:404-18. 2000
    ..Furthermore, we show that dPTEN does not play a major role in cell survival during Drosophila development. Our results provide a potential explanation for the high frequency of PTEN mutation in human cancer...
  88. ncbi High-speed video analysis of wing-snapping in two manakin clades (Pipridae: Aves)
    Kimberly S Bostwick
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
    J Exp Biol 206:3693-706. 2003
    ..above-the-back wing-against-wing claps, (2). wing-against-body claps and (3)...
  89. ncbi Wing beat kinematics of a nectar-feeding bat, Glossophaga soricina, flying at different flight speeds and Strouhal numbers
    Ulla M Lindhe Norberg
    Department of Zoology, Goteborg University, Box 463, SE 405 30 Goteborg, Sweden
    J Exp Biol 209:3887-97. 2006
    High-speed film analysis showed that the wing beat kinematics in Glossophaga soricina change gradually with increasing flight speed, indicating that there is no sudden gait change at any particular, critical, flight speed...
  90. pmc Mapping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster
    W Jason Kennington
    Centre for Evolutionary Biology, School of Animal Biology, The University of Western Australia, Crawley, Western Australia 6009, Australia
    Genetics 177:549-56. 2007
    ..Here, we use an association mapping technique to identify genomic regions controlling variation in wing size within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster...
  91. doi Wake structure and wing kinematics: the flight of the lesser dog-faced fruit bat, Cynopterus brachyotis
    Tatjana Y Hubel
    Division of Engineering, Brown University, Providence RI 02912, USA
    J Exp Biol 213:3427-40. 2010
    ..High speed recordings of the kinematics were conducted to obtain three-dimensional reconstructions of wing movements...
  92. pmc Genomic sequence around butterfly wing development genes: annotation and comparative analysis
    Inês C Conceição
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    PLoS ONE 6:e23778. 2011
    ..genome is yet available despite the unique genetic and biological properties of this group, such as diversified wing color patterns...
  93. pmc A single origin for nymphalid butterfly eyespots followed by widespread loss of associated gene expression
    Jeffrey C Oliver
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America
    PLoS Genet 8:e1002893. 2012
    ....
  94. doi Sublethal effects of four insecticides on the reproduction and wing formation of brown planthopper, Nilaparvata lugens
    Haibo Bao
    Key Laboratory of Monitoring and Management of Plant Disease and Insects, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China
    Pest Manag Sci 65:170-4. 2009
    ..Here, the effects of sublethal doses of these four insecticides on the reproduction and wing formation in BPH were examined.
  95. doi Developmental plasticity in sexual roles of butterfly species drives mutual sexual ornamentation
    Kathleen L Prudic
    Ecology and Evolutionary Biology, Yale University, 165 Prospect Street, New Haven, CT 06511, USA
    Science 331:73-5. 2011
    ..Thus, reciprocal selection through time may result in mutual sexual ornamentation...
  96. pmc Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation
    Valeria P Carreira
    Departamento de Ecologia, Genetica y Evolucion, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II C1428 EHA Buenos Aires, Argentina
    BMC Dev Biol 11:32. 2011
    The Drosophila wing represents a particularly appropriate model to investigate the developmental control of phenotypic variation...
  97. doi Proteomic and transcriptomic analyses of rigid and membranous cuticles and epidermis from the elytra and hindwings of the red flour beetle, Tribolium castaneum
    Neal T Dittmer
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, United States
    J Proteome Res 11:269-78. 2012
    ..This research shows that the elyra and hindwings, representatives of rigid and soft cuticles, have different protein and gene expression profiles for structural proteins that may influence the mechanical properties of these cuticles...
  98. pmc Evolutionary history of the recruitment of conserved developmental genes in association to the formation and diversification of a novel trait
    Leila T Shirai
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, P 2780 156 Oeiras, Portugal
    BMC Evol Biol 12:21. 2012
    ..Eyespots have greatly diversified under natural and sexual selection, and their formation involves genetic circuitries shared across insects...
  99. pmc Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing
    Jun Chen
    Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 139:2170-6. 2012
    The sensitivity of the posterior crossvein in the pupal wing of Drosophila to reductions in the levels and range of BMP signaling has been used to isolate and characterize novel regulators of this pathway...
  100. ncbi Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs
    B Biehs
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA ucsd edu
    Development 125:4245-57. 1998
    ..that vein primordia in Drosophila form at boundaries along the A/P axis between discrete sectors of the larval wing imaginal disc...
  101. pmc Linkage of butterfly mate preference and wing color preference cue at the genomic location of wingless
    Marcus R Kronforst
    Section of Integrative Biology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6575-80. 2006
    ..Heliconius butterflies, well known for their diversity of wing color patterns, mate assortatively as a result of divergence in male preference for wing patterns...

Research Grants75

  1. INTERNET ENHANCED HEALTH PROMOTION FOR OBESE ETHNIC MINORITY ADOLESCENTS
    Jessica A Whiteley; Fiscal Year: 2011
    ..quality of life (Rashid &Roberts, 2000;Rosenbloom, 2002;Sorof, Lai, Turner, Poffenbarger, &Portman, 2004;Wing et al., 2003)...
  2. Erika Litvin Bloom; Fiscal Year: 2016
    ..Brown), clinical trials methodology (Dr. Brown, Dr. Kahler, co- mentor Dr. Rena Wing), body image and weight concerns of women (co-mentor Dr. J. Kevin Thompson, Dr...
  3. Kathryn E Demos; Fiscal Year: 2015
    ..Throughout the course of the award Dr. Demos will work closely with her primary mentor, Dr. Rena Wing, and her multidisciplinary team of co- mentors, [Dr. Eduardo Nillni (pathophysiology of obesity), Dr...
  4. Renovation and Infrastructure Upgrade of Laboratory Research Wing at Johns Hopkin
    Michael J Klag; Fiscal Year: 2010
    ..This proposal is for an infrastructure upgrade and modernization of the laboratory facilities housed in the North Wing of the principal building of the Johns Hopkins Bloomberg School of Public Health (JHSPH)...
  5. Suppression of tadpole limbs: a model for organ size regulation
    RICHARD ELINSON; Fiscal Year: 2009
    ..Hairy genes code for repressors of genes, and they can reduce wing development in chick embryos...
  6. Planar Cell Polarity and the Cytoskeleton
    Andreas Jenny; Fiscal Year: 2013
    ..g. stereocilia in the human inner ear or hairs on a fly wing), or the directional migration of cells during convergent extension during vertebrate gastrulation...
  7. Udai B Pandey; Fiscal Year: 2016
    ..We found that expression of mutant FUS in the fly muscles leads to held-up wing phenotype, muscle degeneration and mitochondrial degeneration...
  8. Andreas Bergmann; Fiscal Year: 2016
    ..For instance, despite massive apoptotic tissue loss of up to 60% triggered by ionizing radiation, Drosophila wing imaginal discs induce regenerative cell proliferation which generates adult wings of normal proportion and size...
  9. Jason Lillis; Fiscal Year: 2016
    ..The WCDRC is a premiere obesity research center led by Dr. Rena Wing. The goal of the this Mentored Patient-Oriented Research Award (K23) proposal is to allow Dr...
  10. Mapping and rescuing EMS-induced lethal mutations on the Drosophila X Chromosome
    Hugo J Bellen; Fiscal Year: 2010
    ..We screened for mutations that affect numerous biological processes, including eye, head, wing, thorax and bristle development, photoreceptor growth cone guidance, synapse formation, synaptic transmission, and ..
  11. PROTEOGLYCANS IN GROWTH FACTOR SIGNALING AND DEVELOPMENT
    Scott B Selleck; Fiscal Year: 2010
    ..that regional control of Wg gradients are achieved by a combination of Dip and Notum activity in the developing wing. Our studies of the synapse employ direct measures of endocytosis using fluorescent dyes that are incorporated into ..
  12. Bursicon Receptor Antagonists: Templates for Developing Novel Insecticides
    Alan S Kopin; Fiscal Year: 2013
    ..genetic down-regulation of bursicon-mediated signaling results in defective hardening of the cuticle, inhibition of wing expansion, and compromised viability...
  13. Rena R Wing; Fiscal Year: 2014
    ..Rena Wing, The Miriam Hospital, and a Data Coordinating Center, submitted by Dr...
  14. MARK ANDREW ESPELAND; Fiscal Year: 2014
    ..Rena Wing, The Miriam Hospital, and a Data Coordinating Center, submitted by Dr...
  15. Deborah A Wing; Fiscal Year: 2014
    ..Deborah Wing (PI) and the Pathik Wadhwa (co-l) have extensive experience in study design, subject recruitment, data analysis, ..
  16. Rutgers University Cell and DNA Repository Renovation
    JAY ARNOLD TISCHFIELD; Fiscal Year: 2010
    ..We propose renovation of the east end of the 2nd floor of C Wing, Nelson Biology Laboratories (NBL) to create facilities for automated (robotic) nucleic acid extraction, ..
  17. Frederic Y M Wan; Fiscal Year: 2014
    ..Focusing on the BMP gradient that patterns the antero-posterior axis of the Drosophila wing imaginal disc, we will explore and elucidate the mechanistic basis for robust patterning, through a collaborative ..
  18. Expandable Shape-Memory Polymers for Suture Anchors
    Christopher M Yakacki; Fiscal Year: 2011
    ..as a tap-in style device, in which the shape- memory effect will be mechanically activated to expand into a wing-shaped device and offer instant fixation...
  19. JASON ROBERT JESSEN; Fiscal Year: 2016
    ..between cells to establish and maintain polarity in a planar tissue? Extensive characterization of PCP in the fly wing epithelium demonstrates those antagonistic interactions between Van Gogh and Frizzled (Fz)/Disheveled (Dsh) ..
  20. Recruiting and Retaining Young Adults in Behavioral Weight Loss Treatment
    JESSICA GOKEE LAROSE; Fiscal Year: 2013
    ..The resources at the Miriam Hospital/ Brown Medical School and close contact with her expert mentor team (Drs. Wing, Jelalian, Morrow, Lewis and Fava) will provide her with the ideal environment to achieve her training and research ..
  21. Spinal abnormalities in neurofibomatosis type 1
    David H Viskochil; Fiscal Year: 2010
    ..This disorder is associated with spinal abnormalities, long bone dysplasia, and sphenoid wing dysplasia...
  22. Characterization of sar-agr Interactions in S. aureus
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
    ..from our collaborator suggested that SarA is a winged helix protein, with residues R84 and R90 within the "wing" region critical to DNA binding while acidic residues D88 and E89 (part of the wing) and D8 and En (within the ..
  23. Pamela K Geyer; Fiscal Year: 2016
    ..The goal of this proposal is to define the function of the prototypic Suppressor of Hairy-wing [Su(Hw)] protein, the DNA binding component of the gypsy insulator. Three aims are proposed...
  24. Stephanie E Gline; Fiscal Year: 2014
    ..ligand Netrin is known for its conserved role in chemorepulsion through the activation of the receptor Unc5 (Lai Wing Sun et al., 2011)...
  25. THOMAS LEE TURNER; Fiscal Year: 2015
    ..with characterization of male courtship song production: during courtship, a Drosophila male extends a single wing and "twangs" this wing repeatedly to produce a wing vibration song consisting of a series of pulses...
  26. Differential regulation of BMP signals in vivo.
    Kristi Wharton; Fiscal Year: 2009
    ..the role of BMP signaling in the specification of different cell fates across the developing Drosophila wing imaginal disc have proven that this system is an ideal one to study the molecular mechanisms governing morphogen ..
  27. Iswar K Hariharan; Fiscal Year: 2014
    ..This preference may be absolute such as the clear separation of anterior and posterior cells in leg and wing discs or relative, such as the tendency of clonal boundaries to fall along the equator in the developing Drosophila ..
  28. Managing obesity by combining behavioral weight loss and commercial approaches
    Angela Marinilli Pinto; Fiscal Year: 2010
    ..Dr. Pinto will work closely with her primary mentor, Dr. Rena Wing, and her co-mentors, Drs...
  29. Role of parenting skills, style, and family functioning in pediatric weight loss
    Kyung E Rhee; Fiscal Year: 2013
    ..The resources at The Miriam Hospital/ Brown Medical School and close contact with her expert mentoring team (Drs. Wing, Dickstein, Jelalian, and Seifer) will provide Dr...
  30. Hans G Othmer; Fiscal Year: 2016
    ..projects are: (1) studies on dorsal-ventral patterning in Drosophila, (2) studies on growth and patterning in the wing disc of Drosophila, an (3) studies on dorsal-ventral patterning in the African frog Drosophila, Xenopus laevis...
  31. COBRE in Stem Cell Biology and Regenerative Medicine
    Don Wojchowski; Fiscal Year: 2012
    ..to bolster our Program;#3] Further develop key core facilities;#4] Continue to fortify infrastructure (new research wing, State biomedical bonds);and #5] Support new interactive seed projects towards synergistic co-investigator programs,..
  32. Jefferson Alumni Hall 3 West Lab Modernization
    Steven E McKenzie; Fiscal Year: 2010
    ..We propose in this Facilities Modernization application to renovate the West Wing of the 3rd floor of JAH, 18,557 net assignable square feet (30% of the current floor footprint) into modern wet ..
  33. Jackson Hall Animal Physiology, Behavioral Phenotyping and Imaging Research Core
    Mark S Paller; Fiscal Year: 2010
    ..There are two Specific Aims: 1) Renovate the North Wing of the 1st floor of Jackson Hall (3,042 SF) to accommodate the relocation and expansion of the existing Biomedical ..
  34. Genetic Study of Heparan Sulfate Function in Development
    Hiroshi Nakato; Fiscal Year: 2013
    ..cell (GSC) niche in the developing ovary through a different mode of action from their activity in the developing wing. We propose to elucidate the molecular mechanisms by which HSPGs regulate the formation of the Drosophila GSC niche...
  35. Richard S Mann; Fiscal Year: 2016
    ..One goal is to understand, at a molecular level, how the initial leg and wing primordia become established in the early embryo...
  36. John P Cooke; Fiscal Year: 2015
    ..Project 1: Novel Regulators to enhance IPSC Derivation and Differentiation to EC (Helen Blau, Wing Wong)...
  37. Building, understanding and applying a dictionary of genetic effects
    David Houle; Fiscal Year: 2013
    ..b>Wing shape in Drosophila melanogaster is an excellent model system for this because the phenotype can readily be ..
  38. Sally Horne-Badovinac; Fiscal Year: 2014
    ..Pioneering work on this phenomenon in the fly wing and eye led to the discovery of the Frizzled planar cell polarity pathway, which is now known to shape the ..
  39. Kettering Lab Renovation to enhance PHS-supported environmental health research
    Shuk Mei Ho; Fiscal Year: 2010
    ..The building that houses this department is showing its age, with one wing already beyond repair...
  40. KATHRYN MARIE ROSS; Fiscal Year: 2014
    ..Kathryn Middleton will work closely with her distinguished mentor, Dr. Rena Wing, and project consultant, Dr. Pedro Goal, throughout the course of this award...
  41. Kristi A Wharton; Fiscal Year: 2014
    ..signaling activity and its importance in the specification of different cell fates across the developing Drosophila wing have proven that this system is an ideal one to study the molecular mechanisms regulating BMP signaling...
  42. Recruitment of a translational researcher for leukemia
    Janis L Abkowitz; Fiscal Year: 2010
    ..The University of Washington School of Medicine (SOM) will commit laboratory space in the K-wing of the Health Sciences Building in excess of that typically provided to beginning Assistant Professors...
  43. Erika A Bach; Fiscal Year: 2014
    ..A clonal growth assay in the Drosophila wing disc will be used to generate winners that express hyper-active Stat92E but lack the candidate gene and then to ..
  44. Rena R Wing; Fiscal Year: 2016
    ..g., YMCAs). We have retained and augmented our successful training model for this cycle, with Program Director Rena Wing, PhD, Associate Director Bess Marcus, PhD, and Administrative Director Justin Nash, PhD, continuing in their ..
  45. DON MICHAEL WOJCHOWSKI; Fiscal Year: 2016
    ..These include the construction of a new research wing, the ongoing recruitment of additional scientists, the advancement of existing core facilities, and the development ..
  46. MOLECULAR CHARACTERIZATION OF THE DORSAL MORPHOGEN
    Michael S Levine; Fiscal Year: 2012
    ..neuronal cell types in the neural tube of vertebrateembryos,and the Dpp gradient that patterns the developing wing imaginal disk in Drosophila larvae...
  47. Molecular Mechanisms of Morphogen Gradient Formation
    Hiroshi Nakato; Fiscal Year: 2010
    ..to control the disposition of the morphogens, Decapentaplegic (Dpp), a BMP4 homolog, and Wingless (Wg), during wing development...
  48. Jeffrey D Axelrod; Fiscal Year: 2016
    ..Specifically, we propose to first probe the global and core modules and network architecture in two tissues, wing and abdomen, in which the output is hair polarization, but in which mutually exclusive model architectures have ..
  49. Increasing Physical Activity Among Inactive Bariatric Surgery Patients
    Dale S Bond; Fiscal Year: 2013
    ..Dr. Bond will work closely with his mentor, Dr. Rena Wing, and his multidisciplinary team of co-mentors Drs...
  50. The effect of periodic input on measures of olfactory processing and perception
    Kevin C Daly; Fiscal Year: 2013
    ..ability is mediated by local antennal lobe processing and centrifugal input that is related to the generation of wing movement...
  51. Innovative AIDS Research Housing for Nonhuman Primates
    Stuart Zola; Fiscal Year: 2013
    ..To alleviate this issue, we propose to convert part of a chimpanzee housing facility, the Yerkes Great Ape Wing (GAW), into innovative AIDS research housing (IARH) with seven monkey suites and14 adjacent runs, housing up to 16 ..
  52. Software &Hardware Inference Engines for Automated Determination of Primary Cell
    Garry P Nolan; Fiscal Year: 2011
    ..Teresa Meng, Stanford and John Wawrzynek (UC Berkeley), in conjunction with advances in statistical theory (Wing Wong, Stanford) for these studies...
  53. Enhancing Core Animal Facilities to Promote Biosecurity and Biosafety
    Sue Vandewoude; Fiscal Year: 2012
    ..machine (24"W x 36"H x 48"D) that is no longer serviceable;and, (2) renovate the entry/exit area of a specialized wing of the animal facility, currently housing guinea pigs at Animal Biosafety Level 3 containment for Mycobacterial ..
  54. Phase II Construction of NCNPR Research Wing
    Larry A Walker; Fiscal Year: 2010
    ..of the University of Mississippi's National Center for Natural Products Research (NCNPR) Phase II research wing. This will entail addition of the top two floors, with completion of a portion of the first floor of this research ..
  55. Mechanism of long-range repression by Groucho: role of the central domains
    WIAM M TURKI JUDEH; Fiscal Year: 2010
    ..variants will be assayed for their ability to drive ectopic repression of Brinker targets when misexpressed in the wing disc...
  56. Wnt Signaling in Synaptic Prepattern formation and Motor Axon Guidance
    Laura R Gordon; Fiscal Year: 2011
    ..Third, in many systems including the Drosophila wing disk, cellular polarity is initially established by asymmetric localization of various members of the planar cell ..
  57. Novel approaches to neural regeneration: Defining new genes &pathways
    Nancy M Bonini; Fiscal Year: 2012
    ..In pilot studies in living adult animals, we have severed the wing nerve bundle with a laser and observed degeneration of the nerve tract...
  58. Xiaoyan Zheng; Fiscal Year: 2015
    ..The Drosophila wing imaginal disc is subdivided into an anterior (A) and a posterior (P) compartment...
  59. Einstein Stem Cell Research Institute
    Allen M Spiegel; Fiscal Year: 2010
    ..Given its key role in Einstein's Strategic Plan, the SCRI has been committed a full wing in the new $200 million Price Center for Genetic and Translational Medicine, plus resources for faculty recruitment ..
  60. Technology for automated real-time counting and identification of adult mosquitoe
    PHILIPP KIRSCH; Fiscal Year: 2007
    ..monitoring system integrates electronic photo-sensors with computer-analysis software to quantify and classify wing-beat signatures...
  61. UMass BSL-3 Renovation
    JOHN LEWIS SULLIVAN; Fiscal Year: 2010
    ..the 6th, 7th, 8th floors, and roof level of the University of Massachusetts Medical School's (UMMS) research wing. The renovation plan will consolidate, enlarge, and enhance the University's existing BSL-3 laboratory, ..
  62. Neuroendocrine Pathways Governing Energy Homeostasis
    Florence Ying Lee; Fiscal Year: 2010
    ..Vgll2 is a mammalian homolog of the Drosophila gene Vestigial (Vg) required for wing development...
  63. MOLECULAR-GENETIC ANALYSIS OF 3P14 GENOMIC STABILITY
    Harry Drabkin; Fiscal Year: 2006
    ..growth suppressive with several distinct phenotypes, and overexpression of Trc8 and Vhl together produces a unique wing phenotype...
  64. Addition and Expansion of Laboratory Animal Research Fa*
    HARRY ROZMIAREK; Fiscal Year: 2009
    ..Laboratory Animal Facility (LAF) in the West Building of the Fox Chase Cancer Center by adding a four-floor wing onto the current facility...
  65. BUILDING C RENOVATION WEST WING
    James Blanchard; Fiscal Year: 2002
    ..Funds are requested to modify the west wing of Building C to help meet the needs of expanding research program...
  66. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    TIMOTHY POOLE; Fiscal Year: 1992
    ..renovations of space formerly used for cage preparation and storage on the second floor of the SPF Barrier Breeding wing into functional animal housing space...
  67. Renovation of MSU/CVM Cage Wash Facilities: G20 Facilities Improvement Grant Appl
    LUCY SENTER; Fiscal Year: 2009
    ..The cage wash facility on Research Wing 1A is equipped with a 23 year old single door Basil RW4600 cage washer that routinely breaks down on average every ..
  68. Improving the Fox Chase Cancer Center Animal Resources
    HARRY ROZMIAREK; Fiscal Year: 2009
    ..as possible to make more space available for research mice and in February 2006 converted a former rodent breeding wing (3,000 sq. ft.) on the second floor into a barrier research area for transgenic and immunodeficient research mice...
  69. EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION
    WILLIAM RIFFEE; Fiscal Year: 2003
    ..the final phase (Phase 2B) renovation of wet-lab research facilities on the ground floor of the Pharmacy Research Wing. The UF-COP is currently in the midst of doing a complete renovation of all outdated and deteriorating wet-lab ..
  70. IMMUNOBIOLOGY, CANCER, AND ARTHRITIS LABORATORIES
    J Capra; Fiscal Year: 1999
    ..handicapped bathrooms, and shared conference and research office space to connect the newly renovated south wing to the east wing of the OMRF building on the 3rd and 4th level...
  71. ASRI RODENT FACILITY IMPROVEMENT PROJECT
    ERIC COTTINGTON; Fiscal Year: 1993
    ..The remainder of the rodent facility is located in the newer East Wing, which, because of its capacity for modern utilities and fewer access points, is a natural site for centralizing ..