forelimb

Summary

Summary: A front limb of a quadruped. (The Random House College Dictionary, 1980)

Top Publications

  1. ncbi Properties of primary motor cortex output to forelimb muscles in rhesus macaques
    Michael C Park
    Department of Molecular and Integrative Physiology, and Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160 7336, USA
    J Neurophysiol 92:2968-84. 2004
  2. pmc The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture
    Kelly A Tennant
    Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Cereb Cortex 21:865-76. 2011
  3. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
  4. ncbi Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci Methods 115:169-79. 2002
  5. ncbi Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury
    J Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    J Neurosci 21:5272-80. 2001
  6. ncbi Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Brain 135:1253-67. 2012
  7. pmc Radiographs reveal exceptional forelimb strength in the sabertooth cat, Smilodon fatalis
    Julie A Meachen-Samuels
    Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11412. 2010
  8. ncbi Endurance exercise facilitates relearning of forelimb motor skill after focal ischemia
    Michelle Ploughman
    Basic Medical Sciences, Faculty of Medicine, Memorial University, St John s, NL, Canada A1B 3V6
    Eur J Neurosci 25:3453-60. 2007
  9. ncbi Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
    Elizabeth J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 134:4335-45. 2007
  10. pmc Output properties and organization of the forelimb representation of motor areas on the lateral aspect of the hemisphere in rhesus macaques
    Marie Hélène Boudrias
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Cereb Cortex 20:169-86. 2010

Detail Information

Publications378 found, 100 shown here

  1. ncbi Properties of primary motor cortex output to forelimb muscles in rhesus macaques
    Michael C Park
    Department of Molecular and Integrative Physiology, and Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160 7336, USA
    J Neurophysiol 92:2968-84. 2004
    Stimulus-triggered averaging (StTA) of electromyographic (EMG) activity from 24 simultaneously recorded forelimb muscles was used to investigate properties of primary motor cortex (M1) output in the macaque monkey...
  2. pmc The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture
    Kelly A Tennant
    Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Cereb Cortex 21:865-76. 2011
    The organization of forelimb representation areas of the monkey, cat, and rat motor cortices has been studied in depth, but its characterization in the mouse lags far behind...
  3. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..These tests include forelimb use for weight shifting during vertical exploration in a cylindrical enclosure, an adhesive removal test of ..
  4. ncbi Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci Methods 115:169-79. 2002
    The ladder rung walking test is a new task to assess skilled walking and measure both forelimb and hindlimb placing, stepping, and inter-limb co-ordination...
  5. ncbi Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury
    J Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    J Neurosci 21:5272-80. 2001
    Chronic impairment of forelimb and digit movement is a common problem after stroke that is resistant to therapy...
  6. ncbi Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Brain 135:1253-67. 2012
    ..analyses revealed that this rewired corticospinal tract functionally linked to motor neurons and forelimb muscles...
  7. pmc Radiographs reveal exceptional forelimb strength in the sabertooth cat, Smilodon fatalis
    Julie A Meachen-Samuels
    Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11412. 2010
    ..Previous studies on forelimb bones of S. fatalis found them to be relatively robust but did not quantify their ability to withstand loading.
  8. ncbi Endurance exercise facilitates relearning of forelimb motor skill after focal ischemia
    Michelle Ploughman
    Basic Medical Sciences, Faculty of Medicine, Memorial University, St John s, NL, Canada A1B 3V6
    Eur J Neurosci 25:3453-60. 2007
    ..occlusion in male Sprague-Dawley rats, endurance exercise would act synergistically with a challenging skilled forelimb task to facilitate motor recovery...
  9. ncbi Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
    Elizabeth J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 134:4335-45. 2007
    ..Blimp1 plays essential roles in multipotent progenitor cell populations in the posterior forelimb, caudal pharyngeal arches, secondary heart field and sensory vibrissae and maintains key signalling centres at ..
  10. pmc Output properties and organization of the forelimb representation of motor areas on the lateral aspect of the hemisphere in rhesus macaques
    Marie Hélène Boudrias
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Cereb Cortex 20:169-86. 2010
    Motor output capabilities of the forelimb representation of dorsal motor area (PMd) and ventral motor area (PMv) were compared with primary motor cortex (M1) in terms of latency, strength, sign, and distribution of effects...
  11. ncbi Immediate constraint-induced movement therapy causes local hyperthermia that exacerbates cerebral cortical injury in rats
    Suzanne B DeBow
    Department of Psychology, Centre for Neuroscience, University of Alberta, Edmonton, Canada
    Can J Physiol Pharmacol 82:231-7. 2004
    ..Surprisingly, immediate ipsilateral forelimb immobilization exacerbates brain injury in rats...
  12. ncbi Effects of platelet-rich plasma on the repair of wounds on the distal aspect of the forelimb in horses
    Susana O Monteiro
    Ecole Nationale Veterinaire de Lyon, Département hippique, Marcy l Etoile, F 69280, France
    Am J Vet Res 70:277-82. 2009
    To evaluate the effect of platelet-rich plasma on wounds on the distal aspect of the forelimb in horses.
  13. ncbi A dual role for Hox genes in limb anterior-posterior asymmetry
    Jozsef Zakany
    Department of Zoology and Animal Biology and National Program Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Science 304:1669-72. 2004
    ..This signal is subsequently translated into digit morphological asymmetry by promoting the late expression of Hoxd genes, two collinear processes relying on opposite genomic topographies, upstream and downstream Shh signaling...
  14. ncbi Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study
    Rick M Dijkhuizen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 23:510-7. 2003
    ..Functional activation and cerebrovascular reactivity maps were generated from contrast-enhanced fMRI during forelimb stimulation and hypercapnia, respectively. Before MRI, rats were examined neurologically...
  15. ncbi The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination
    Guido C Koopmans
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, Maastricht, The Netherlands
    J Neurotrauma 22:214-25. 2005
    ..A limitation within the BBB locomotor rating scale is the correct assessment of forelimb (FL)-hindlimb (HL) coordination...
  16. ncbi Back seat driving: hindlimb corticospinal neurons assume forelimb control following ischaemic stroke
    Michelle Louise Starkey
    Department of Health Sciences and Technology, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Brain 135:3265-81. 2012
    ..In the present study, we selectively destroyed large parts of the forelimb motor and premotor cortex of adult rats with an ischaemic injury...
  17. pmc Limb-bone scaling indicates diverse stance and gait in quadrupedal ornithischian dinosaurs
    Susannah C R Maidment
    Department of Palaeontology, Natural History Museum, London, United Kingdom
    PLoS ONE 7:e36904. 2012
    ..For example, it has been proposed that some ornithischians could run, while others consider that none were cursorial...
  18. ncbi Behavioral recovery from unilateral photothrombotic infarcts of the forelimb sensorimotor cortex in rats: role of the contralateral cortex
    E V Shanina
    Department of Neurology, Friedrich Schiller University, Jena, Germany
    Neuroscience 139:1495-506. 2006
    ..One group of animals received a unilateral single photothrombotic infarct in the forelimb sensorimotor cortex, while four additional groups received a second lesion in the contralateral homotopic cortex ..
  19. pmc Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice
    Albrecht Sigler
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research, Brain Research Center, University of British Columbia, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 106:11759-64. 2009
    ..sensory-evoked depolarization in mouse somatosensory cortex within hours after targeted stroke to a subset of the forelimb sensory map...
  20. pmc A form of motor cortical plasticity that correlates with recovery of function after brain injury
    Dhakshin Ramanathan
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0626, USA
    Proc Natl Acad Sci U S A 103:11370-5. 2006
    ..This evidence suggests the existence of complex movement representations in the rat motor cortex that exhibit plasticity after injury and rehabilitation, serving as a relevant predictor of functional recovery...
  21. ncbi Spatial and cortical influences exerted on cuneothalamic and thalamocortical neurons of the cat
    A Canedo
    Department of Physiology, Faculty of Medicine, Laboratory of Neuroscience and Neuronal Computation, associated to the Cajal Institute CSIC, Santiago de Compostela, Spain
    Eur J Neurosci 12:2515-33. 2000
    ..The data indicate that the cortico-subcortical feedback contributes not only to enhance the surround antagonism of a centre response but also to increase the time resolution of thalamic and cuneate relay somesthetic neurons...
  22. pmc Hox genes regulate the onset of Tbx5 expression in the forelimb
    Carolina Minguillon
    Division of Developmental Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Development 139:3180-8. 2012
    ..are two closely related T-box genes that encode transcription factors expressed in the prospective hindlimb and forelimb territories, respectively, of all jawed vertebrates...
  23. pmc Lateralization of forelimb motor evoked potentials by transcranial magnetic stimulation in rats
    Alexander Rotenberg
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Neurophysiol 121:104-8. 2010
    ..for human transcranial magnetic stimulation (TMS) in rats, we tested whether lateralized cortical stimulation resulting in selective activation of one forelimb contralateral to the site of stimulation could be achieved by TMS in the rat.
  24. pmc Forelimb EMG-based trigger to control an electronic spinal bridge to enable hindlimb stepping after a complete spinal cord lesion in rats
    Parag Gad
    Biomedical Engineering IDP, University of California, Los Angeles, CA 90095, USA
    J Neuroeng Rehabil 9:38. 2012
    ..The objective of this study was to develop an electronic bridge across the lesion of the spinal cord to facilitate hindlimb stepping after a complete mid-thoracic spinal cord injury in adult rats...
  25. pmc Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation
    Samir M Abdelmagid
    Department of Surgery, Plastic and Reconstructive Division, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e38359. 2012
    ....
  26. ncbi Optimal parameters for microstimulation derived forelimb movement thresholds and motor maps in rats and mice
    Nicole A Young
    Department of Psychology, University of Calgary, Calgary, AB, Canada T2N 1N4
    J Neurosci Methods 196:60-9. 2011
    ..neocortical depth, and current polarity to achieve the minimum current intensity (movement threshold) to elicit forelimb movements in rats and mice...
  27. ncbi Testing forelimb placing "across the midline" reveals distinct, lesion-dependent patterns of recovery in rats
    Martin T Woodlee
    Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA
    Exp Neurol 191:310-7. 2005
    We describe a new test of vibrissae-elicited forelimb placing ability that allows testing of sensorimotor integration across the midline...
  28. ncbi Distinct cortical circuit mechanisms for complex forelimb movement and motor map topography
    Thomas C Harrison
    Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Neuron 74:397-409. 2012
    ..We applied light-based motor mapping of Channelrhodopsin-2 mice to reveal a functional subdivision of the forelimb motor cortex based on the direction of movement evoked by brief (10 ms) pulses...
  29. ncbi Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasks
    Mary F Barbe
    Department of Physical Therapy, College of Health Professions, Temple University, 3307 North Broad Streeet, Philadelphia, PA 19140, USA
    J Orthop Res 26:1320-6. 2008
    ..Serum was assayed for 11 cytokines and chemokines; forelimb tissues for four cytokines...
  30. pmc Forelimb-hindlimb developmental timing changes across tetrapod phylogeny
    Olaf R P Bininda-Emonds
    Institute of Biology, University of Leiden, Kaiserstraat 63, 2311GP, Leiden, The Netherlands
    BMC Evol Biol 7:182. 2007
    ..histological sections were used to code the appearance of 10 developmental events comprising landmarks of development from the early bud stage to late chondrogenesis in the forelimb and the corresponding serial homologues in the hindlimb.
  31. ncbi Spinal substance P and neurokinin-1 increase with high repetition reaching
    Melanie B Elliott
    Department of Physical Therapy, Temple University, 3307 North Broad St, Philadelphia, PA 19140, United States
    Neurosci Lett 454:33-7. 2009
    ..The relationship of these spinal cord changes with the number of TNFalpha immunopositive cells in flexor forelimb muscles and with previously observed forearm grip strength changes from these same rats were examined...
  32. ncbi Differential involvement of excitatory and inhibitory neurons of cat motor cortex in coincident spike activity related to behavioral context
    David Putrino
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 30:8048-56. 2010
    ..Pairs of NTR and TR neurons showed associations in their firing patterns over wide areas of MI (representing forelimb and hindlimb movements) during quiet sitting, more commonly involving RS neurons...
  33. ncbi Early exclusive use of the affected forelimb after moderate transient focal ischemia in rats : functional and anatomic outcome
    S T Bland
    Department of Psychology, University of Texas, Austin, TX 78712, USA
    Stroke 31:1144-52. 2000
    Previous work by researchers in our laboratory has shown that in the rat, the exclusive use of the affected forelimb during an early critical period exaggerates lesion volume and retards functional recovery after electrolytic lesions of ..
  34. ncbi Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo
    Pooja Agarwal
    Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 130:623-33. 2003
    ..We report that mouse embryos lacking Tbx5 do not form forelimb buds, although the patterning of the lateral plate mesoderm into the limb field is intact...
  35. ncbi Enriched environment promotes efficiency of compensatory movements after cerebral ischemia in rats
    M Knieling
    Hans Berger Clinic of Neurology, Friedrich Schiller University, 07740 Jena, Germany
    Neuroscience 163:759-69. 2009
    ..This study focused on the time course of functional recovery versus motor compensation in skilled forelimb movements after cerebral ischemia in rats...
  36. ncbi Properties of propriospinal neurons in the C3-C4 segments mediating disynaptic pyramidal excitation to forelimb motoneurons in the macaque monkey
    Tadashi Isa
    Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    J Neurophysiol 95:3674-85. 2006
    Candidate propriospinal neurons (PNs) that mediate disynaptic pyramidal excitation to forelimb motoneurons were studied in the C3-C4 segments in anesthetized macaque monkeys (n = 10)...
  37. pmc Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish
    Joshua S Waxman
    Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 15:923-34. 2008
    ..Here, we identify a mechanism in which signaling within the forelimb field restricts the potential of the neighboring heart field...
  38. pmc Lack of evidence for direct corticospinal contributions to control of the ipsilateral forelimb in monkey
    Demetris S Soteropoulos
    Institute of Neuroscience, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, UK
    J Neurosci 31:11208-19. 2011
    Strong experimental evidence implicates the corticospinal tract in voluntary control of the contralateral forelimb. Its potential role in controlling the ipsilateral forelimb is less well understood, although anatomical projections to ..
  39. ncbi Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery
    J Girgis
    McGill University, Centre for Neuronal Survival, Montreal, Canada
    Brain 130:2993-3003. 2007
    ..Thereupon, the cortical forelimb area was electrophysiologically examined using micro-stimulation followed by tracing of the lesioned ..
  40. ncbi Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord
    Karim Fouad
    University of Alberta, Faculty of Rehabilitation Medicine, Edmonton, Canada T6G 2G4
    J Neurosci 25:1169-78. 2005
    ..Significant improvements were observed in the Basso, Beattie, and Bresnahan score and in forelimb/hindlimb coupling...
  41. ncbi Genetic variation and genetic trends in hip and elbow dysplasia in Swedish Rottweiler and Bernese Mountain Dog
    S Malm
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Anim Breed Genet 125:403-12. 2008
    ..Based on the results, a statistical model for routine prediction of breeding values for HD and ED in Swedish dogs was suggested...
  42. ncbi Load redistribution in walking and trotting Beagles with induced forelimb lameness
    Jalal Abdelhadi
    Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany
    Am J Vet Res 74:34-9. 2013
    To evaluate the load redistribution mechanisms in walking and trotting dogs with induced forelimb lameness.
  43. pmc Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis
    Lindsay Hamilton
    Brain Repair Centre and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    BMC Neurosci 8:77. 2007
    ..To achieve this potential a robust method of functional analysis is required so that statistical comparison of numerical data derived from treated and control animals can be achieved...
  44. ncbi Use of a stand-alone pressure plate for the objective evaluation of forelimb symmetry in sound ponies at walk and trot
    Maarten Oosterlinck
    Department of Surgery and Anaesthesiology, Faculty of Veterinary Medicine, Ghent University, B 9820 Merelbeke, Belgium
    Vet J 183:305-9. 2010
    ..of this study was to determine whether equine pressure plate measurements are repeatable when used to calculate forelimb loading (peak vertical pressure [PVP], peak vertical force [PVF], vertical impulse [VI]) and symmetry ratios, and ..
  45. pmc Functional MRI detection of bilateral cortical reorganization in the rodent brain following peripheral nerve deafferentation
    Galit Pelled
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, B1D728, 10 Center Drive, Bethesda, MD, USA
    Neuroimage 37:262-73. 2007
    ....
  46. pmc Motor skill training, but not voluntary exercise, improves skilled reaching after unilateral ischemic lesions of the sensorimotor cortex in rats
    Monica A Maldonado
    Institute for Neuroscience, University of Texas at Austin, Austin, Texas, USA
    Neurorehabil Neural Repair 22:250-61. 2008
    ..Because motor skill training induces synaptic plasticity and exercise increases plasticity-related proteins, we asked if exercise could improve the efficacy of training on a skilled motor task after focal cortical lesions...
  47. ncbi Responses of infragranular neurons in the rat primary somatosensory cortex to forepaw and hindpaw tactile stimuli
    K A Moxon
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Neuroscience 156:1083-92. 2008
    ..Tutunculer B, Foffani G, Himes BT, Moxon KA (2006) Structure of the excitatory receptive fields of infragranular forelimb neurons in the rat primary somatosensory cortex responding to touch. Cereb Cortex 16:791-810]...
  48. ncbi Getting a grip on the evolution of grasping in musteloid carnivorans: a three-dimensional analysis of forelimb shape
    A C Fabre
    Centre de recherche sur la paléobiodiversité et les paléoenvironnements UMR 7207 Centre National de Recherche Scientifique, Museum national d histoire naturelle, Univ Paris 06, Paris, France
    J Evol Biol 26:1521-35. 2013
    ..We predict that if grasping is derived from an arboreal lifestyle, then the anatomical specializations of the forelimb for arboreality must be similar to those involved in grasping...
  49. pmc Ancestry of motor innervation to pectoral fin and forelimb
    Leung Hang Ma
    Department of Physiology and Neuroscience, NYU Langone Medical Center, New York, New York 10016, USA
    Nat Commun 1:49. 2010
    Motor innervation to the tetrapod forelimb and fish pectoral fin is assumed to share a conserved spinal cord origin, despite major structural and functional innovations of the appendage during the vertebrate water-to-land transition...
  50. ncbi Effects of mass distribution on the mechanics of level trotting in dogs
    David V Lee
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    J Exp Biol 207:1715-28. 2004
    ..During trotting, the forelimb exerts a net braking force while the hindlimb exerts a net propulsive force...
  51. ncbi Activity of extrinsic limb muscles in dogs at walk, trot and gallop
    Stephen M Deban
    Department of Integrative Biology, 4202 East Fowler Avenue, SCA 110, University of South Florida, Tampa, FL 33620, USA
    J Exp Biol 215:287-300. 2012
    ..We recorded electromyographic activity of 23 extrinsic forelimb and hindlimb muscles and one trunk muscle in dogs while they walked, trotted and galloped on a level treadmill...
  52. ncbi Behavioral tests after intracerebral hemorrhage in the rat
    Ya Hua
    Department of Neurosurgery, University of Michigan, Ann Arbor 48109 0532, USA
    Stroke 33:2478-84. 2002
    ..The purpose of this study was to use a battery of sensorimotor function tests to examine the neurological effects of ICH in the rat and to examine which components of the hematoma are involved in generating those effects...
  53. ncbi Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents
    Rie Kimura
    Brain Science Institute, Tamagawa Univ, 6 1 1 Tamagawa gakuen, Machida, Tokyo 194 8610, Japan
    J Neurophysiol 108:1781-92. 2012
    ..inappropriate for head-fixed rodents to be operantly conditioned to perform skilled movements with their forelimb (e.g., lever-press task), despite the potential applicability of the task...
  54. ncbi Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice
    Michelle L Starkey
    Regeneration Group, King s College London, Wolfson Centre for Age Related Diseases, Hodgkin Building, Guy s Campus, London Bridge, London, SE1 IUL, UK
    Eur J Neurosci 36:3665-78. 2012
    ..of the intact corticospinal tract (CST) following unilateral injury and restore function to the denervated forelimb. Adult C57BL/6 mice underwent unilateral pyramidotomy and treatment with either ChABC or a vehicle control...
  55. ncbi Deep brain stimulation of the substantia nigra pars reticulata improves forelimb akinesia in the hemiparkinsonian rat
    Alexander C Sutton
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    J Neurophysiol 109:363-74. 2013
    ..We demonstrate improvement of forelimb akinesia with SNr-HFS and suggest that this motor effect may have resulted from the attenuation of SNr neuronal ..
  56. pmc Fore-aft ground force adaptations to induced forelimb lameness in walking and trotting dogs
    Jalal Abdelhadi
    University of Veterinary Medicine Hannover, Foundation, Small Animal Clinic, Hannover, Germany
    PLoS ONE 7:e52202. 2012
    ..understand their compensatory mechanisms, this study evaluated the changes in the fore-aft ground forces to forelimb lameness and tested the hypothesis that dogs unload the affected limb by producing a nose-up pitching moment via ..
  57. pmc Motor cortex electrical stimulation promotes axon outgrowth to brain stem and spinal targets that control the forelimb impaired by unilateral corticospinal injury
    Jason B Carmel
    Departments of Neurology and Neuroscience and Pediatrics, Weill Cornell Medical College, New York, NY 10021, USA
    Eur J Neurosci 37:1090-102. 2013
    ..in the rat increased corticospinal tract (CST) axon length, strengthened spinal connections, and restored forelimb function...
  58. ncbi Genetic analyses of elbow and hip dysplasia in the German shepherd dog
    K F Stock
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover Foundation, Germany
    J Anim Breed Genet 128:219-29. 2011
    ....
  59. pmc Cervical intraspinal microstimulation evokes robust forelimb movements before and after injury
    Michael D Sunshine
    Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA
    J Neural Eng 10:036001. 2013
    ..is capable of evoking a variety of highly-functional movements prior to injury, but the ability of ISMS to evoke forelimb movements after cervical spinal cord injury is unknown...
  60. ncbi Wing-assisted incline running and the evolution of flight
    Kenneth P Dial
    Flight Laboratory, Avian Studies Program, Division of Biological Sciences, University of Montana UM, Missoula, MT 59812, USA
    Science 299:402-4. 2003
    ..WAIR provides insight from behaviors observable in living birds into the possible role of incipient wings in feathered theropod dinosaurs and offers a previously unstudied explanation for the evolution of avian flight...
  61. ncbi Compensatory load redistribution of horses with induced weight-bearing forelimb lameness trotting on a treadmill
    Michael A Weishaupt
    Equine Hospital, Faculty of Veterinary Medicine, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Vet J 171:135-46. 2006
    ..to obtain a detailed insight into the load and time shifting mechanisms of horses with unilateral weight-bearing forelimb lameness. Reversible lameness was induced in 11 clinically sound horses by applying a solar pressure model...
  62. ncbi Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats
    T A Jones
    Department of Psychology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 19:10153-63. 1999
    ..the acrobatic task) on synaptic changes in layer V of the motor cortex opposite unilateral damage to the forelimb sensorimotor cortex (FLsmc)...
  63. pmc Aging contributes to inflammation in upper extremity tendons and declines in forelimb agility in a rat model of upper extremity overuse
    David M Kietrys
    Department of Rehabilitation and Movement Sciences, University of Medicine and Dentistry of New Jersey, School of Health Related Professions, Stratford, New Jersey, United States of America
    PLoS ONE 7:e46954. 2012
    ..The percentage of successful reaches improved in young adult HRLF rats, but not in aged HRLF rats. Forelimb agility decreased transiently in young adult HRLF rats, but persistently in aged HRLF rats...
  64. ncbi Systemic inflammatory mediators contribute to widespread effects in work-related musculoskeletal disorders
    Ann E Barr
    Physical Therapy Department, College of Health Professions, Temple University, Philadelphia, PA, USA
    Exerc Sport Sci Rev 32:135-42. 2004
    ..A systemic inflammatory component may affect tissues not directly involved in task performance, thereby contributing to widespread and puzzling symptoms that are often characteristic of patients with WMSDs...
  65. ncbi Distribution of vertical forces in the pads of Greyhounds and Labrador Retrievers during walking
    M Faulkner Besancon
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Am J Vet Res 65:1497-501. 2004
    ..To document peak vertical force (PVF) and vertical impulse (VI) in the pads of Greyhounds and Labrador Retrievers...
  66. ncbi Shape of articular surface of crocodilian (Archosauria) elbow joints and its relevance to sauropsids
    Shin ichi Fujiwara
    The University Museum, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Morphol 271:883-96. 2010
    ..This, in turn, helps to determine the maximum angle of extension of the elbow joint in archosaurs...
  67. pmc Sensorimotor experience influences recovery of forelimb abilities but not tissue loss after focal cortical compression in adult rats
    Marina Martinez
    CNRS UMR 6149, Integrative and Adaptive Neurosciences, Pôle 3 C, IFR 131, University of Provence, Marseilles, France
    PLoS ONE 6:e16726. 2011
    ..interactions on the time course of both lesion and gliosis volumes as well as on the recovery of forelimb sensorimotor abilities following focal cortical injury...
  68. ncbi Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex
    Jeffrey A Kleim
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada, T1K 3M4
    Neurobiol Learn Mem 77:63-77. 2002
    ..No expansion of hindlimb representations was seen. This functional reorganization was restricted to the caudal forelimb area, as no differences in the topography of movement representations were observed within the rostral forelimb ..
  69. ncbi Association between subjective lameness grade and kinetic gait parameters in horses with experimentally induced forelimb lameness
    Akikazu Ishihara
    Departmentof Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210 1089, USA
    Am J Vet Res 66:1805-15. 2005
    To evaluate the association between subjective lameness grades and kinetic gait parameters and assess the variability in kinetic parameters in horses with experimentally induced forelimb lameness.
  70. ncbi Unexpected changes of rat cervical spinal cord tolerance caused by inhomogeneous dose distributions
    Hendrik P Bijl
    Department of Radiation Oncology, University Hospital Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 57:274-81. 2003
    ..The effects of dose distribution on dose-effect relationships have been evaluated and, from this, iso-effective doses (ED(50)) established...
  71. ncbi Rostrocaudal branching within the climbing fibre projection to forelimb-receiving areas of the cerebellar cortical C1 zone
    R Apps
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Comp Neurol 419:193-204. 2000
    ..In each experiment (n = 7), a small injection of rhodamine-tagged beads was made into the forelimb-receiving part of the C1 zone in one region of the cortex, and an injection of fluorescein-tagged beads was made ..
  72. ncbi Not so fast: speed effects on forelimb kinematics in cercopithecine monkeys and implications for digitigrade postures in primates
    Biren A Patel
    Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, OH 45701, USA
    Am J Phys Anthropol 140:92-112. 2009
    ..4-3.4 m/s). Three-dimensional forelimb kinematic data were recorded during forelimb support...
  73. ncbi Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex
    J K Chapin
    Department of Neurobiology and Anatomy, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Nat Neurosci 2:664-70. 1999
    ..With continued training in neurorobotic mode, the animals' lever movement diminished or stopped. These results suggest a possible means for movement restoration in paralysis patients...
  74. ncbi A new clade of archaic large-bodied predatory dinosaurs (Theropoda: Allosauroidea) that survived to the latest Mesozoic
    Roger B J Benson
    Department of Earth Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EQ, UK
    Naturwissenschaften 97:71-8. 2010
    ..Instead, clades were nearly cosmopolitan in their early history, and later distributions are explained by sampling failure or local extinction...
  75. ncbi Bi-hemispheric contribution to functional motor recovery of the affected forelimb following focal ischemic brain injury in rats
    Jeff Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University, St John s, NL, Canada A1B 3V6
    Eur J Neurosci 21:989-99. 2005
    ..Following middle cerebral artery occlusion, rats received intensive enriched-rehabilitation (ER) of the impaired forelimb for 4 weeks...
  76. ncbi Subthalamic stimulation-induced forelimb dyskinesias are linked to an increase in glutamate levels in the substantia nigra pars reticulata
    Sabrina Boulet
    Dynamique des Réseaux Neuronaux, Institut National de la Sante et de la Recherche Medicale, Unité 704, F 38041 Grenoble, France
    J Neurosci 26:10768-76. 2006
    ..STN-HFS at an intensity corresponding to the threshold inducing contralateral forelimb dyskinesia, increased Glu levels in the SNr of both intact and hemiparkinsonian rats...
  77. ncbi Rewiring of hindlimb corticospinal neurons after spinal cord injury
    Arko Ghosh
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Nat Neurosci 13:97-104. 2010
    ..Mapping of these neurons revealed the emergence of a new forelimb corticospinal projection from the rostral part of the former hindlimb cortex...
  78. ncbi Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats
    John C Gensel
    STAR Laboratories, Laboratory for Neural Repair, Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:36-54. 2006
    ..Compared to controls, animals receiving SCI exhibited injury severity-specific deficits in forelimb, locomotor, and hindlimb function persisting for 6-weeks post-SCI...
  79. pmc Axial Hox9 activity establishes the posterior field in the developing forelimb
    Ben Xu
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Proc Natl Acad Sci U S A 108:4888-91. 2011
    ..Here we show that initial anteroposterior polarization of the early forelimb field requires the function of all four Hox9 paralogs (Hoxa9, Hoxb9, Hoxc9, and Hoxd9)...
  80. ncbi Quantitative assessment of deficits and recovery of forelimb motor function after cervical spinal cord injury in mice
    Kim D Anderson
    Departments of Anatomy and Neurobiology, Neurobiology and Behavior, and Neurosurgery, Reeve Irvine Research Center, College of Medicine, University of California at Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 190:184-91. 2004
    ..cord injuries (SCIs) in humans are at the cervical (C) level, but there are few tests to quantitatively assess forelimb motor function after cervical spinal cord injury in rodents...
  81. pmc Role of TNF alpha and PLF in bone remodeling in a rat model of repetitive reaching and grasping
    Shobha Rani
    Department of Anatomy and Cell Biology, Temple Medical School, Philadelphia, Pennsylvania 19140, USA
    J Cell Physiol 225:152-67. 2010
    ..attenuated task-induced increases in inflammatory cytokines (TNFalpha, IL-1alpha, and MIP2 in serum; TNFalpha in forelimb bone and muscles) and serum osteocalcin in 6-week HRHF animals...
  82. ncbi A stepwise model system for limb regeneration
    Tetsuya Endo
    Department of Developmental and Cell Biology and the Developmental Biology Center, University of California Irvine, Irvine, CA 92697, USA
    Dev Biol 270:135-45. 2004
    ..Hence, this novel and convenient stepwise model allows for the discovery of necessary and sufficient signals and conditions that control blastema formation, growth, and pattern formation during limb regeneration...
  83. ncbi Oscillatory activity in forelimb muscles of behaving monkeys evoked by microstimulation in the cerebellar nuclei
    T D Aumann
    Department of Physiology and Biophysics, and Washington National Primate Research Center, University of Washington, Seattle, WA 98195 7290, USA
    Neurosci Lett 361:106-10. 2004
    ..step-tracking task while we recorded neuronal activity or microstimulated in CN and recorded EMG activity from forelimb muscles...
  84. ncbi The effects of intracortical endothelin-1 injections on skilled forelimb use: implications for modelling recovery of function after stroke
    Gary Gilmour
    Eli Lilly and Co Ltd, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, UK
    Behav Brain Res 150:171-83. 2004
    ..Lesions were unilateral and were targeted at the forelimb representation zone in sensorimotor cortex...
  85. ncbi Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod
    Anne M Boulet
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Development 131:299-309. 2004
    ..Similarly, in mice with disruptions of both Hoxa13 and Hoxd13, development of the forelimb and hindlimb autopod is severely curtailed...
  86. pmc The vermicelli handling test: a simple quantitative measure of dexterous forepaw function in rats
    Rachel P Allred
    Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    J Neurosci Methods 170:229-44. 2008
    ..during spontaneous food handling in rats: postures, bimanual coordination, preferences, and the effect of forelimb cortex lesions. Behav Brain Res 1996;77:135-48]...
  87. ncbi Quantitative inter-segmental and inter-laminar comparison of corticospinal projections from the forelimb area of the primary motor cortex of macaque monkeys
    K Yoshino-Saito
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Neuroscience 171:1164-79. 2010
    Corticospinal projections from the forelimb area of the primary motor cortex to the C2-Th2 spinal cord segments were quantitatively analyzed using the high resolution anterograde tracer, biotinylated dextran amine (BDA), in rhesus monkeys ..
  88. pmc Peripheral and central changes combine to induce motor behavioral deficits in a moderate repetition task
    Jacques Olivier Coq
    UMR 6149 Neurobiologie Intégrative et Adaptative, CNRS Aix Marseille Universite, Pole 3C, Case B, 3 Place Victor Hugo, 13331, Marseille Cedex 03, France
    Exp Neurol 220:234-45. 2009
    ..in IL-1 beta and TNF-alpha negatively correlated with grip strength and amount of current needed to evoke forelimb movements...
  89. ncbi Forelimb indicators of prey-size preference in the Felidae
    Julie Meachen-Samuels
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA
    J Morphol 270:729-44. 2009
    ..We also compared the scaling of felid forelimbs to those of canids to test whether prey capture strategies affect forelimb scaling...
  90. ncbi Ladder beam and camera video recording system for evaluating forelimb and hindlimb deficits after sensorimotor cortex injury in rats
    J S Soblosky
    Department of Neurosurgery, Louisiana State University Medical Center, New Orleans 70112, USA
    J Neurosci Methods 78:75-83. 1997
    Hindlimb and forelimb deficits in rats caused by sensorimotor cortex lesions are frequently tested by using the narrow flat beam (hindlimb), the narrow pegged beam (hindlimb and forelimb) or the grid-walking (forelimb) tests...
  91. pmc Early and late changes in the distal forelimb representation of the supplementary motor area after injury to frontal motor areas in the squirrel monkey
    Ines Eisner-Janowicz
    Department of Molecular and Integrative Physiology Department and Landon Center on Aging, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Neurophysiol 100:1498-512. 2008
    ..microstimulation (ICMS) techniques were used to monitor changes in representational maps of the distal forelimb in the supplementary motor area (SMA) after a unilateral ischemic infarct of primary motor (M1) and premotor ..
  92. ncbi Neural activity related to reaching and grasping in rostral and caudal regions of rat motor cortex
    B Hyland
    Department of Physiology and Neuroscience Research Centre, University of Otago, Dunedin, New Zealand
    Behav Brain Res 94:255-69. 1998
    ..These features were broadly similar in neurones from both the caudal and rostral subdivisions of rat motor cortex...
  93. pmc The extent of the preserved feathers on the four-winged dinosaur Microraptor gui under ultraviolet light
    David W E Hone
    Key Laboratory of Evolutionary Systematics of Vertebrates, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 5:e9223. 2010
    ..This taxon has important implications for the origin of flight in birds and the possibility of a four-winged gliding phase...
  94. ncbi Cortical stimulation improves skilled forelimb use following a focal ischemic infarct in the rat
    G Campbell Teskey
    Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Neurol Res 25:794-800. 2003
    ..This study examined skilled forelimb behavior, neocortical evoked potentials, and movement thresholds to assess cortical electrical stimulation ..
  95. pmc Maladaptive effects of learning with the less-affected forelimb after focal cortical infarcts in rats
    Rachel P Allred
    Psychology Department, University of Texas at Austin, Austin, TX 78712, USA
    Exp Neurol 210:172-81. 2008
    ..a rat model of focal cortical infarct to examine how motor skill acquisition with the less-affected ("intact") forelimb influences sensorimotor function of the infarct-impaired forelimb and neural activity in peri-infarct cortex...
  96. ncbi Quantitative assessment of forelimb motor function after cervical spinal cord injury in rats: relationship to the corticospinal tract
    Kim D Anderson
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, University of California at Irvine College of Medicine, 1105 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4292, USA
    Exp Neurol 194:161-74. 2005
    ..a critical need to develop experimental models for cervical SCI and techniques to assess deficits and recovery of forelimb motor function...
  97. pmc Tactile responses of hindpaw, forepaw and whisker neurons in the thalamic ventrobasal complex of anesthetized rats
    J Aguilar
    Neurosignals Group, Fundación del Hospital Nacional de Parapléjicos para la Investigación y la Integración, SESCAM, Finca La Peraleda s n, 45071 Toledo, Spain
    Eur J Neurosci 27:378-87. 2008
    ..Our results support the view of a neurophysiologically homogeneous ventrobasal complex, in which OFF responses participate in the structure of the spatiotemporal receptive field of thalamocortical neurons for tactile stimuli...
  98. ncbi Differential topography of the bilateral cortical projections to the whisker and forepaw regions in rat motor cortex
    Elizabeth M Colechio
    Department of Neural and Behavioral Sciences H109, Hershey Medical Center, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033 2255, USA
    Brain Struct Funct 213:423-39. 2009
    Whisker and forelimb movements in rats have distinct behavioral functions that suggest differences in the neural connections of the brain regions that control their movements...
  99. ncbi Hoxd13 expression in the developing limbs of the short-tailed fruit bat, Carollia perspicillata
    Chih Hsin Chen
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Evol Dev 7:130-41. 2005
    ..In bat and mouse hindlimbs, the expression patterns of Hoxd13 are relatively similar. However, although the forelimb Hoxd13 expression patterns in both organisms during early limb bud stages are similar, at later stages they ..
  100. ncbi A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 106:709-21. 2001
    ..Tbx5(del/+) mice were generated to study the mechanisms by which TBX5 haploinsufficiency causes cardiac and forelimb abnormalities seen in Holt-Oram syndrome...
  101. pmc Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury
    Jason Sharp
    Reeve Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, Department of Anatomy and Neurobiology, School of Medicine, 2111 Gillespie Neuroscience Research Facility, University of California at Irvine, Irvine, California 92697 4292, USA
    Stem Cells 28:152-63. 2010
    ..hESC-derived OPC transplants attenuated lesion pathogenesis and improved recovery of forelimb function...

Research Grants65

  1. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2013
    ..Structural repair will be assessed by anatomical tract tracing and immunocytochemical labeling;forelimb-hindlimb coordination will be assessed by kinematic and electromyogram (EMG) analysis;functional reconnection ..
  2. Biomarker of Tissue Tolerance and Behavior in a Rat Model of WMSD
    Mary F Barbe; Fiscal Year: 2013
    ..b>Forelimb tissues will be collected bilaterally and prepared for the various analyses These experiments will enhance our ..
  3. Intranasal deferoxamine to treat stroke in young and older, male and female rats
    SAMUEL SCOTT PANTER; Fiscal Year: 2013
    ..Rats will undergo 120 minute MCAO and be given an acute neurological assessment comprised of postural reflex and forelimb placing tests at 60 minutes after the onset of stroke to confirm a neurological deficit...
  4. Neural Substrates of Oral Motor Dysfunction in Parkinson's Disease
    EMILY KATE PRINE; Fiscal Year: 2010
    ..that striatal dopamine depletion does indeed differentially affect the neural circuits controlling lingual versus forelimb function...
  5. Characterization of Striatal Nitric Oxide Signaling
    Anthony West; Fiscal Year: 2009
    ..that of sGC inhibition transiently attenuated the reduction in adjusting steps observed in the contralateral forelimb of 6-OHDA-lesioned rats...
  6. Interactions between Urological and Locomotor Systems during Treadmill Training i
    Patricia J Ward; Fiscal Year: 2012
    ..Two other groups forelimb trained (n=20) and non-trained (n=20) will be tested simultaneously...
  7. Cervical spinal injury and demyelination in aged rats
    Michael S Beattie; Fiscal Year: 2010
    ..Rats will be followed with a panel of neurological outcome measures, including forelimb motor function tests and tests for the development of altered sensation (e.g. allodynia and pain)...
  8. Cortical Control of Hindlimb Muscles in Primates
    PAUL DAVID CHENEY; Fiscal Year: 2012
    ..of hindlimb cortical control toward a larger goal of developing a knowledge base that parallels that for the forelimb. Toward this goal, we propose the following six specific aims: 1) to determine the properties of muscles ..
  9. Role of IGF-1 and Estrogen in Skeletal Anabolic Response to Loading
    Chandrasekhar Kesavan; Fiscal Year: 2011
    ..ML will be induced by four-point bending in the tibia or axial compression of forelimb. In vivo pQCT and Real time RT-PCR will be used to quantitate changes in bone parameters (loaded and non-loaded ..
  10. OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADING
    Matthew J Silva; Fiscal Year: 2013
    ..Using the rat forelimb loading model, we recently quantified a rapid increase in vascularity after damaging fatigue loading of bone, ..
  11. Stress-Induced Depression and Parkinsonian Symptomology
    Kim B Seroogy; Fiscal Year: 2012
    ..In the context of the dopaminergic mesotelencephalic system, each of these aims will be addressed by using forelimb-use asymmetry behavioral tests, tyrosine hydroxylase immunohistochemistry, HPLC analysis of dopamine and its ..
  12. Role of D3 receptors in drug-induced impulsivity in a rat model of Parkinson's di
    STEPHANIE E TEDFORD; Fiscal Year: 2013
    ..In Aim 1, I will evaluate the effects of PPX at a low dose suprathreshold to improving motor deficits in the forelimb step task in the probability discounting task...
  13. Immunotherapy to Improve Functional Outcomes after Chronic Stoke in the Aged
    GWENDOLYN LOUISE KARTJE; Fiscal Year: 2012
    ..Specific Aim #3- Determine if movements in the stroke-impaired forelimb return to pre-stroke movement patterns or if other compensatory strategies occur after stroke and anti-Nogo-A ..
  14. Mechanisms of Large-scale Reorganization in Rat Forepaw Barrel Subfiels Cortex
    Robert S Waters; Fiscal Year: 2010
    ..Incomplete understanding of the effects of forelimb amputation on central nervous system processing limits our ability to ameliorate these deficits or to develop ..
  15. Characterization of the mechanisms underlying rubrospinal control of movement
    NALINI ANNE COLACO; Fiscal Year: 2011
    ..Although lesion studies have implicated the rubrospinal tract in the control of skilled forelimb movements, the specific circuitry which underlies the rubrospinal contribution to motor output has yet to be ..
  16. Enabling forelimb function with agonist drug and epidural stimulation in SCI
    Daniel Lu; Fiscal Year: 2013
    ..e., electrode placement and stimulation intensity, frequency and duration, for facilitating forelimb fine motor function in rats with a cervical SCI...
  17. Functional architecture of motor cortex: Topography and connections
    DYLAN FRANCIS COOKE; Fiscal Year: 2011
    ..in a rough somatotopic pattern, with the muscles of the hindlimb represented medially and the muscles of the forelimb and face represented progressively more laterally...
  18. Rehabilitative Training Effects on Corticofugal Plasticity after Cortical Damage
    STEPHANIE CHRISTINE JEFFERSON; Fiscal Year: 2013
    ..The caudal motor cortex (CMC) has been found to posses the capacity to promote rapid recovery of skilled forelimb function after rostral motor cortex (RMC) lesions, but the opposite does not hold true after lesions of the CMC...
  19. Mechanisms and efficacy of myostatin inhibition in myotubular myopathy
    MICHAEL WILLIAM LAWLOR; Fiscal Year: 2013
    ..studies have shown that treatment of the more severe, Mtm144 mice causes an transient increase in weight, forelimb grip strength, and lifespan...
  20. NEURAL CONTROL OF MUSCLE ACTIVITY
    Eberhard E Fetz; Fiscal Year: 2012
    ..The activity of premotor (PreM) cells (identified by correlational linkages to forelimb motoneurons) and multiple muscles will be documented during multidirectional wrist movements and grip...
  21. CORTICAL CONTROL OF MOVEMENT
    Asaf Keller; Fiscal Year: 2010
    ..humans, contains a gross somatotopic representation of the major divisions of the body, such as hindlimb, forelimb, and face...
  22. Limb-type specific distinct upstream regulation of a common Hand2-Shh pathway
    Yasuhiko Kawakami; Fiscal Year: 2013
    ..is reported that in Hox9 quadruple knockout (Hox-a9, b9, c9, d9), Hand2 and Shh expression were not activated in forelimb buds, while expression of Hand2 and Shh in hindlimb buds was normal...
  23. Hox Genes in Limb Patterning
    Deneen M Wellik; Fiscal Year: 2010
    ..in which only the AbdB-related Hox genes (Hox9-13) from the HoxA and HoxD complex are required in the developing forelimb. No loss-of-function mutants in HoxB or HoxC group genes have ever been demonstrated to have forelimb defects...
  24. Mechanisms of Neural Repair in White Matter Stroke
    STANLEY THOMAS CARMICHAEL; Fiscal Year: 2013
    ..We have recently developed a model of subcortical stroke in white matter below the mouse forelimb motor cortex that models many aspects of this disease in humans...
  25. Role of Hox Genes in Integration of the Musculoskeletal System in Development
    Deneen M Wellik; Fiscal Year: 2013
    ..mechanisms of Hox function in the development and integration of muscle, tendon and bone in the developing forelimb and how these mechanisms are redeployed in response to injury...
  26. Role of Ectodermal Signals in Limb Bud Outgrowth and Development
    Trevor J Williams; Fiscal Year: 2010
    ..of these molecular changes are that limb formation is induced along the entire lateral axis between the forelimb and hindlimb buds...
  27. Motor learning and neuroplasticity in an aged mouse model of cerebral ischemia
    Kelly A Tennant; Fiscal Year: 2010
    ..in the motor cortex will be assessed using intracortical microstimulation (ICMS) to derive motor maps of the forelimb area of motor cortex and immunohistochemical analyses of activity and plasticity-associated proteins, ..
  28. Neurovascular Mechanisms of Time-Dependencies in Stroke Rehabilitation
    Yi Zuo; Fiscal Year: 2013
    ..This will be studied in a mouse model of chronic upper extremity (forelimb) impairments resulting from unilateral ischemic motor cortical damage in which functional impairments are ..
  29. Tomographic In Vivo Flow Cytometer for Counting Rare Circulating Cells
    MARK JONATHAN NIEDRE; Fiscal Year: 2011
    ..utilizes a miniaturized high-speed tomographic ring design that will fit around a small limb (such as the forelimb, hindleg or tail) of an animal and allow extremely sensitive detection with blood flow rates up to 0.2 to 0...
  30. Hand use and neuronal plasticity after spinal cord injury
    Corinna Darian-Smith; Fiscal Year: 2013
    ..provided by applicant): Spinal nerve and cord injuries that result in the partial deafferentation of the forelimb and hand can severely impair hand function, especially the execution of manual tasks that depend on continuous ..
  31. Rehabilitative Training Effects on Vascular Plasticity following Cerebral Infarct
    ABIGAIL LAROSA KERR; Fiscal Year: 2011
    ..2, the same lesion model will be used as in Aim 1, with the addition of animals receiving paretic and nonparetic forelimb motor training (skilled reaching)...
  32. Diffusion tensor imaging of the injured spinal cord
    Shekar N Kurpad; Fiscal Year: 2013
    ..changes correlated with increased proliferation of pain fibers, which functionally resulted in the development of forelimb allodynia...
  33. Cortical Stimulation to Enhance Experience-Dependent Plasticity After Stroke
    Theresa A Jones; Fiscal Year: 2010
    ..ischemic infarcts of the sensorimotor cortex and rehabilitative training in skilled reaching to improve forelimb function. There are three specific aims...
  34. Use of Engineered Nervous Tissue Constructs to Repair Extensive Nerve Injury
    Jason H Huang; Fiscal Year: 2013
    ..part of this study, we will attempt major reconstruction of brachial plexus injury in rodents, spanning the forelimb from the vertebrae to the paw using our living nervous tissue constructs...
  35. In-vivo Rat Brain PET Study of Task Specific Motor Recovery After Stroke
    Shih Yen Tsai; Fiscal Year: 2013
    ..using 5PET/5CT imaging to detect brain activity of rats corresponding to a specific motor activity, the skilled forelimb reaching task...
  36. Optical Imaging of Cerebellar Plasticity In Vivo
    TIMOTHY EBNER; Fiscal Year: 2009
    ..to the changes in cerebellar cortical activity that occur with adaptation to a mechanical perturbation of a forelimb reaching movement...
  37. MOTOR FUNCTIONS AND FIBER CONNECTIONS OF PALLIDUM
    SAMUEL LILES; Fiscal Year: 1990
    ..in the striatum and pallidum to electrical stimulation of the cortical areas of representation of the distal forelimb in primary motor cortex, primary somesthetic cortex, supplementary motor area (SMA), and posterior acute area (..
  38. Preclinical Motor Function in Aging and Parkinsonism
    John A Stanford; Fiscal Year: 2010
    ..In addition, the PI plans to develop a forelimb force control task into a method to study functional cortical organization and reorganization as a function of ..
  39. Mechanisms of secondary injury after SCI
    Jacqueline C Bresnahan; Fiscal Year: 2013
    ..single and combination therapies to maximize six week recovery after unilateral cervical SCI using a variety of forelimb functional tests (grooming, paw placement, Catwalk and IBB)...
  40. Neural Mechanisms of Compensating for Brain Damage
    Theresa A Jones; Fiscal Year: 2013
    ..as a result of its interaction with ischemia-triggered regenerative responses, learning to rely on the nonparetic forelimb promotes a major neuronal growth response in the contralesional motor cortex, a response that has no known ..
  41. Elucidation of molecular networks required to limit cardiac cell number
    JOSHUA WAXMAN; Fiscal Year: 2012
    ..hoxbSb, a downstream effector of RA signaling, non-autonomously restricts atrial cell number from the adjacent forelimb field...
  42. ACTIVITY REFINES CORTICOSPINAL TERMINATIONS
    John H Martin; Fiscal Year: 2010
    ..Our studies show that CS system activity and forelimb use radically transform the distribution and morphology of CS axon terminals, which is established by intrinsic ..
  43. Plasticity and Regeneration in the Primate Spinal Cord
    Mark H Tuszynski; Fiscal Year: 2013
    ..Aim 1: Examine Electrophysiological and Anatomical Mechanisms Underlying Spontaneous Forelimb Functional Improvement After Primate SCI...
  44. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
    ..produces a discrete ischemic lesion of the cortex and results in permanent sensory and motor deficits in the forelimb contralateral to the side of injury...
  45. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN LOUISE KARTJE; Fiscal Year: 2011
    ..Specific Aim #3- Determine whether the contralesional forelimb cortex mediates behavioral recovery when anti-Nogo-A immunotherapy is given two months after stroke in the aged ..
  46. Influence of the Basal Ganglia on Cerebellar Action
    Alan Gibson; Fiscal Year: 2007
    ..Our experiments will: 1. Identify regions in the related nuclei that contain cells related to forelimb movement. 2...
  47. Interneuronal mechanisms for the control of walking
    Jianguo Cheng; Fiscal Year: 2009
    ..Intracellular recording will be performed in the in vitro mudpuppy spinal cord-forelimb preparation during walking-like movement of the limbs induced by bath application of glutamate or its agonist ..
  48. Stress stimulated peptides in forced use neuroprotection
    Amanda Smith; Fiscal Year: 2003
    Forced use of the impaired forelimb in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of Parkinson's disease, ameliorates behavioral asymmetry and restores dopamine (DA) content in the striatum when commenced immediately after ..
  49. Lesion and activity dependent corticospinal tract plasticity
    John H Martin; Fiscal Year: 2013
    ..Aim 3C combines cortical and spinal stimulation to restore distal forelimb motor function in a clinically relevant cortical lesion model. !
  50. Microarray Analysis of Limb Bud Reaction to Teratogen E*
    William Scott; Fiscal Year: 2003
    ..activities induce the same, very localized limb malformation, absence of posterior digits from the forelimb, predominantly on the right side i.e., postaxial right forelimb ectrodactyly...
  51. CORTICOSPINAL CONTROL OF FORELIMB MOVEMENT
    Paul Cheney; Fiscal Year: 2002
    ..for work concerned with the synaptic and functional organization of frontal lobe cortical areas in the control of forelimb movements in primates...
  52. PATHOPHYSIOLOGICAL TISSUE CHANGES IN RAT MODEL OF CTD
    ANN BARR; Fiscal Year: 2000
    ..to maintain target repetition rate over time, their success in retrieving food pellets, maximum grip force, and forelimb movement patterns of reaching and grasping during food pellet retrieval...
  53. NEURONAL INTEGRATION IN CEREBELLAR SYSTEMS
    Vlastislav Bracha; Fiscal Year: 2004
    ..of three motor tasks: the classically conditioned eye blink in the rabbit and cat, the classically conditioned forelimb withdrawal reflex in the cat, and an instructed delay reaching paradigm, also in the cat...
  54. SENSORY INTEGRATION IN SOMATOSENSORY-MOTOR CORTEX
    Linda Porter; Fiscal Year: 1993
    ..The relationships of cells in these areas will be studied. The forelimb regions of areas 2, 3a of the sensory cortex and area 4 of the motor cortex will be identified by recording ..
  55. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN L KARTJE MD; Fiscal Year: 2010
    ..Specific aim 2- Determine whether contralesional forelimb cortex mediates recovery after stroke and anti-Nogo-A immunotherapy...
  56. HOXA 11 DEVELOPMENTAL FUNCTION
    S Potter; Fiscal Year: 1999
    ..knockout, including a paralogue of Hoxa 11, resulted in even more profound malformations, with deletions of forelimb structures and absent or rudimentary kidneys at birth...
  57. Long-term skeletal effects of exercise during growth
    Stuart Warden; Fiscal Year: 2009
    ..In each study, bone adaptation will be induced in the right forelimb or hindlimb of young rats using the ulna or tibial axial loading models, respectively...
  58. Basal Ganglia Neurophysiology during DBS in Rats
    Jing Yu Chang; Fiscal Year: 2006
    ..Locomotor d deficits during treadmill walking and imbalance usage of forelimb in vertical exploratory behaviors will develop after unilateral dopamine lesion...
  59. Promotion of Functional Recovery From Demylinating Disease
    George DeVries; Fiscal Year: 2009
    ..developed in our laboratory which results in the functional loss of a behavioral task in our case a skilled forelimb retrieval task...
  60. SUPRASEGMENTAL INFLUENCES ON SPINAL MOTONEURONS
    James Preston; Fiscal Year: 1993
    ..in the rostral part of area 4 and receives input largely from muscle and/or joint receptors located in the distal forelimb. Based on these and other observations we have proposed that the 2 hand representations represent 2 motor control ..
  61. SIGNAL ANALYSIS OF CEREBELLAR CORTICAL NEURONS
    PETER VAN KAN; Fiscal Year: 1990
    ..the electrical signals transmitted by individual neural elements in the cerebellar cortex will be correlated with forelimb movement of monkey subjects...
  62. Hemodynamic forces regulate BMPs in coronary arteries
    Zoltan Ungvari; Fiscal Year: 2009
    ..I found that in aortic banded rats coronary arteries and forelimb arteries which are exposed to high pressure exhibit an increased oxidative stress and an up-regulation of pro-..
  63. CALCIUM BLOCKER AND RELATED THERAPY FOR STROKE RECOVERY
    James Grotta; Fiscal Year: 2004
    ..Forced overuse or disuse of the affected forelimb will increase infarct size, reduce new neuronal connections in cortex, and prevent recovery of forelimb motor ..
  64. Rehabilitative training effect on cell proliferation after cortical damage.
    MONICA MALDONADO; Fiscal Year: 2009
    ..In an effort to (1) target forelimb deficits induced by the lesions and (2) engage remaining cortex in potential plastic events, rehabilitation will ..
  65. Regulation and Function of Tbx4 and Tbx5 in the Limb
    DOUGLAS MENKE; Fiscal Year: 2007
    Tbx4 and Tbx5 are critical for hindlimb and forelimb development, respectively...