living donors

Summary

Summary: Non-cadaveric providers of organs for transplant to related or non-related recipients.

Top Publications

  1. ncbi Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis
    Shujiro Yazumi
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoinkawara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatobiliary Pancreat Surg 13:502-10. 2006
  2. pmc Long-term consequences of kidney donation
    Hassan N Ibrahim
    Department of Medicine, University of Minnesota, Minneapolis 55414, USA
    N Engl J Med 360:459-69. 2009
  3. ncbi Perioperative mortality and long-term survival following live kidney donation
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 303:959-66. 2010
  4. ncbi Evaluation of creatinine-based estimates of glomerular filtration rate in a large cohort of living kidney donors
    Naim Issa
    Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH 44195, USA
    Transplantation 86:223-30. 2008
  5. ncbi MR elastography for noninvasive assessment of hepatic fibrosis: experience from a tertiary center in Asia
    Bo Hee Kim
    Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
    J Magn Reson Imaging 34:1110-6. 2011
  6. pmc A mesenchymal stromal cell gene signature for donor age
    Hugo Alves
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    PLoS ONE 7:e42908. 2012
  7. ncbi Antidonor antibody in patients receiving ABO-identical and HLA-mismatched living donor liver transplants: effect on survival
    Eishi Ashihara
    Department of Blood Transfusion and Cell Therapy, Kyoto, Japan
    Transplantation 83:506-9. 2007
  8. pmc Donor morbidity after living donation for liver transplantation
    Rafik M Ghobrial
    Department of Surgery, University of California Los Angeles, Los Angeles, California, USA
    Gastroenterology 135:468-76. 2008
  9. ncbi Increasing live donor kidney transplantation: a randomized controlled trial of a home-based educational intervention
    J R Rodrigue
    The Transplant Center and the Department of Psychiatry, Beth Israel Deaconess Medical Center, 110 Francis Street, LMOB 7th Floor, Boston, Massachusetts, USA
    Am J Transplant 7:394-401. 2007
  10. ncbi Ethnically diverse populations and their participation in living kidney donation programs
    Joke I Roodnat
    Department of Internal Medicine, Erasmus MC Rotterdam, The Netherlands
    Transplantation 89:1263-9. 2010

Detail Information

Publications339 found, 100 shown here

  1. ncbi Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis
    Shujiro Yazumi
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoinkawara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatobiliary Pancreat Surg 13:502-10. 2006
    ....
  2. pmc Long-term consequences of kidney donation
    Hassan N Ibrahim
    Department of Medicine, University of Minnesota, Minneapolis 55414, USA
    N Engl J Med 360:459-69. 2009
    ..Previous studies have included relatively small numbers of donors and a brief follow-up period...
  3. ncbi Perioperative mortality and long-term survival following live kidney donation
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 303:959-66. 2010
    ..More than 6000 healthy US individuals every year undergo nephrectomy for the purposes of live donation; however, safety remains in question because longitudinal outcome studies have occurred at single centers with limited generalizability...
  4. ncbi Evaluation of creatinine-based estimates of glomerular filtration rate in a large cohort of living kidney donors
    Naim Issa
    Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH 44195, USA
    Transplantation 86:223-30. 2008
    ..However, among transplant centers donor kidney function evaluation varies widely...
  5. ncbi MR elastography for noninvasive assessment of hepatic fibrosis: experience from a tertiary center in Asia
    Bo Hee Kim
    Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
    J Magn Reson Imaging 34:1110-6. 2011
    ..To determine the sensitivity and specificity of MR elastography (MRE) in the staging of hepatic fibrosis (HF) using histopathology as the reference standard in an Asian population...
  6. pmc A mesenchymal stromal cell gene signature for donor age
    Hugo Alves
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    PLoS ONE 7:e42908. 2012
    ..The gene signature presented here could be a useful tool for drug testing to rejuvenate hMSCs or for the selection of more potent, hMSCs for cell-based therapy...
  7. ncbi Antidonor antibody in patients receiving ABO-identical and HLA-mismatched living donor liver transplants: effect on survival
    Eishi Ashihara
    Department of Blood Transfusion and Cell Therapy, Kyoto, Japan
    Transplantation 83:506-9. 2007
    ..5%; negative group, 81.9%; P=3.3x10). We conclude that antidonor antibodies have adverse effects on the clinical outcome of LDLTs, and that being female and/or older aged (>or=18 years of age) are risk factors for LDLT...
  8. pmc Donor morbidity after living donation for liver transplantation
    Rafik M Ghobrial
    Department of Surgery, University of California Los Angeles, Los Angeles, California, USA
    Gastroenterology 135:468-76. 2008
    ..The rate and severity of complications in living donors were investigated in the 9-center Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL).
  9. ncbi Increasing live donor kidney transplantation: a randomized controlled trial of a home-based educational intervention
    J R Rodrigue
    The Transplant Center and the Department of Psychiatry, Beth Israel Deaconess Medical Center, 110 Francis Street, LMOB 7th Floor, Boston, Massachusetts, USA
    Am J Transplant 7:394-401. 2007
    ..0001) and in willingness to discuss LDKT with others (p < 0.0001), and a decrease in LDKT concerns (p < 0.0001). Results indicate that an HB outreach program is more effective in increasing LDKT rates than CB education alone...
  10. ncbi Ethnically diverse populations and their participation in living kidney donation programs
    Joke I Roodnat
    Department of Internal Medicine, Erasmus MC Rotterdam, The Netherlands
    Transplantation 89:1263-9. 2010
    ..We wondered whether a low attendance or a high decline of potential non-European donors could explain this difference...
  11. ncbi Mutations in hepatitis C virus genotype 1b and the sensitivity of interferon-ribavirin therapy after liver transplantation
    Takasuke Fukuhara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Hepatol 52:672-80. 2010
    ..The results of post-transplant antiviral therapy for recurrent hepatitis C virus (HCV) are poor, and significant pre-transplant predictors for sustained viral response (SVR) have not yet been identified...
  12. ncbi Does a positive lymphocyte cross-match contraindicate living-donor liver transplantation?
    Tomohide Hori
    Department of Transplant Surgery, Kyoto University Hospital, Kyoto, Japan
    Surgery 147:840-4. 2010
    ..There is still no consensus on the importance of lymphocyte cross-matching (LCM) in the field of living-donor liver transplantation (LDLT)...
  13. ncbi Positive lymphocytotoxic crossmatch does not adversely affect survival in living donor liver transplantation
    Yasuhiko Sugawara
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Dig Surg 26:482-6. 2009
    ..The influence of lymphocytotoxic crossmatch on survival or acute rejection in liver transplantation remains controversial. Data regarding graft survival and acute rejection of living donor liver transplantation (LDLT) are limited...
  14. doi Underestimating the risk in living kidney donation
    Walter Glannon
    J Med Ethics 34:127-8. 2008
  15. ncbi Proteinuria and reduced kidney function in living kidney donors: A systematic review, meta-analysis, and meta-regression
    A X Garg
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Kidney Int 70:1801-10. 2006
    ..An initial decrement in GFR is not followed by accelerated losses over a subsequent 15 years. Future studies will provide better estimates, and identify those donors at least risk of long-term morbidity...
  16. ncbi Long-term consequences of live kidney donation follow-up in 93% of living kidney donors in a single transplant center
    Jan Gossmann
    Transplantationsambulanz, KfH Nierenzentrum, Schleusenweg 22, 60528 Frankfurt, Germany
    Am J Transplant 5:2417-24. 2005
    ..Because of the high incidence of proteinuria and possible changes in bone metabolism inclusion of kidney donors in registries appears worthwhile...
  17. ncbi Meta-analysis: risk for hypertension in living kidney donors
    Neil Boudville
    University of Western Ontario, London, Ontario, Canada
    Ann Intern Med 145:185-96. 2006
    ..The risk for hypertension after kidney donation remains uncertain...
  18. pmc Association of kidney function and metabolic risk factors with density of glomeruli on renal biopsy samples from living donors
    Andrew D Rule
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905
    Mayo Clin Proc 86:282-90. 2011
    ..To test the hypothesis that kidney function and metabolic risk factors are associated with glomerular density on renal biopsy samples from healthy adults...
  19. pmc Addressing racial and ethnic disparities in live donor kidney transplantation: priorities for research and intervention
    Amy D Waterman
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Semin Nephrol 30:90-8. 2010
    ....
  20. ncbi Accepting kidneys from older living donors: impact on transplant recipient outcomes
    A Young
    Division of Nephrology, University of Western Ontario, Canada
    Am J Transplant 11:743-50. 2011
    ..29 (0.80-2.08)]. In light of an observed trend towards potential differences beyond 4 years, uncertainty remains, and extended follow-up of this and other cohorts is warranted...
  21. ncbi Interaction between tacrolimus and lansoprazole, but not rabeprazole in living-donor liver transplant patients with defects of CYP2C19 and CYP3A5
    Keiko Hosohata
    Department of Pharmacy, Kyoto University Hospital, Kyoto, Japan
    Drug Metab Pharmacokinet 23:134-8. 2008
    ..A drug-drug interaction between rabeprazole and tacrolimus was not observed in this case study presented, suggesting that this combination could be safely used in tacrolimus therapy after liver transplantation...
  22. ncbi Assessment of health-related quality of life in living kidney donors
    N Maglakelidze
    Department of Nephrology and Dialysis, National Centre of Urology, Tbilisi, Georgia
    Transplant Proc 43:373-5. 2011
    ..Donors should be monitored for both physical and psychosocial outcomes of the procedure. Further prospective studies are needed to facilitate potential donors' understanding of the complex issues related to organ donation...
  23. ncbi Donor graft does not affect the P450 2C19 genotype expressed in peripheral blood in recipients of living donor liver transplantation
    King Wah Chiu
    Liver Transplant Program, Chang Gung Memorial Hospital Kaohsiung Medical Center and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Clin Transplant 24:830-4. 2010
    ..Thirty pairs of living donors and recipients were enrolled in this study...
  24. ncbi Nephrectomy elicits impact of age and BMI on renal hemodynamics: lower postdonation reserve capacity in older or overweight kidney donors
    M Rook
    Department of Nephrology, University Medical Center Groningen, VUMC Amsterdam, The Netherlands
    Am J Transplant 8:2077-85. 2008
    ..The presence of overweight had more impact on loss of RC in younger donors. In conclusion, donor nephrectomy unmasked an age- and overweight-induced loss of reserve capacity. Younger donors with obesity should be carefully monitored...
  25. ncbi Pediatric living donor kidney transplantation under alemtuzumab pretreatment and tacrolimus monotherapy: 4-year experience
    Henkie P Tan
    the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 86:1725-31. 2008
    ..Alemtuzumab has been used in off-label studies of solid organ transplantation...
  26. ncbi Short-term impact of an educational program promoting live donor kidney transplantation in dialysis centers
    Francoise G Pradel
    Department of Pharmaceutical Health Services Research, University of Maryland Baltimore School of Pharmacy, 220 Arch Street, Office level one, Baltimore, MD 21201, USA
    Prog Transplant 18:263-72. 2008
    ..Given the shortage of kidneys available for transplantation, a community-based intervention trial was implemented to assess the impact of an educational program on patients' access to live donor kidney transplantation (LDKT)...
  27. ncbi Impact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole, but not lansoprazole, in adult living-donor liver transplant patients
    Keiko Hosohata
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Drug Metab Dispos 37:821-6. 2009
    ....
  28. ncbi Homogenous phenomenon of graft liver CYP2C19 genotypes after living donor liver transplantation
    King Wah Chiu
    Liver Transplant Program, Chang Gung Memorial Hospital Kaohsiung Medical Center and Chang Gung University College of Medicine, Taiwan, China
    Eur J Clin Invest 42:352-6. 2012
    ..The donor liver grafts with different allelic patterns do not affect CYP2C19 genotypes in the peripheral blood of living donor liver transplantation (LDLT) recipients...
  29. ncbi Robot-assisted right lobe donor hepatectomy
    Pier Cristoforo Giulianotti
    Division of Minimally Invasive, General Surgery and Robotic Surgery, University of Illinois at Chicago, Chicago, IL, USA
    Transpl Int 25:e5-9. 2012
    ..To our knowledge, this is the first case reported in the literature. The technical feasibility of this minimally invasive approach is demonstrated, exemplifying the novel exciting opportunities offered by robotic technology...
  30. pmc Staging of hepatic fibrosis: comparison of magnetic resonance elastography and shear wave elastography in the same individuals
    Jeong Hee Yoon
    Department of Radiology, Seoul National University College of Medicine, Seoul 110 744, Korea
    Korean J Radiol 14:202-12. 2013
    ..To cross-validate liver stiffness (LS) measured on shear wave elastography (SWE) and on magnetic resonance elastography (MRE) in the same individuals...
  31. ncbi 2509 living donor nephrectomies, morbidity and mortality, including the UK introduction of laparoscopic donor surgery
    V G Hadjianastassiou
    Directorate of Nephrology, Transplantation and Urology, Level 6, New Guy s House, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    Am J Transplant 7:2532-7. 2007
    ..001). Living donation has remained a safe procedure in the UK during the learning curve of introduction of the laparoscopic procedure. The latter offers measurable advantages to the donor in terms of reduced length of stay and morbidity...
  32. ncbi Donor factors influencing graft outcomes in live donor kidney transplantation
    Naim Issa
    Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH 44195, USA
    Transplantation 83:593-9. 2007
    ..01). In conclusion, our data suggest that routine assessment of living donor parameters could supplement the consideration of recipient characteristics in predicting posttransplant risk of graft injury/dysfunction...
  33. pmc Protocol of a randomized controlled trial of culturally sensitive interventions to improve African Americans' and non-African Americans' early, shared, and informed consideration of live kidney transplantation: the Talking About Live Kidney Donation (TALK
    L Ebony Boulware
    Division of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, 2024 E, Monument Street, Baltimore, MD 21205, USA
    BMC Nephrol 12:34. 2011
    ....
  34. pmc The "House Calls" trial: a randomized controlled trial to reduce racial disparities in live donor kidney transplantation: rationale and design
    James R Rodrigue
    The Transplant Institute and The Center for Transplant Outcomes and Quality Improvement, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Contemp Clin Trials 33:811-8. 2012
    ..Similar trials have been developed recently to broaden the evaluation of House Calls as an innovative disparity-reducing intervention in kidney transplantation...
  35. ncbi Western blotting analysis for quantitative detection of CYP2C19 expression in liver tissues in the setting of living donor liver transplantation
    King Wah Chiu
    Kaohsiung Chang Gung Memorial Hospital, Taiwan, Republic of China
    Hepatogastroenterology 59:805-8. 2012
    ..The aim of the present study was to assess the CYP2C19 protein expression in the setting of living donor liver transplantation (LDLT) by using western blotting analysis...
  36. ncbi Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation
    Takashi Ito
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Liver Transpl 13:1637-44. 2007
    ..4%, respectively; P<0.0001). In conclusion, selection criteria for patients with HCC undergoing LDLT may be safely extended to <or=10 tumors all<or=5 cm in diameter and PIVKA-II<or=400 mAU/mL with acceptable outcomes...
  37. ncbi Incidence of end-stage renal disease among live kidney donors
    Ingela Fehrman-Ekholm
    Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Transplantation 82:1646-8. 2006
    ..The increasing use of living kidney donors requires knowledge about long-term effects, especially number and causes of donors with end-stage renal disease (ESRD)...
  38. pmc Long-term renal function and cardiovascular disease risk in obese kidney donors
    Mohammad M Tavakol
    Division of Transplant Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Clin J Am Soc Nephrol 4:1230-8. 2009
    ..We wished to determine whether obesity increased the risk for renal dysfunction and other medical comorbidities in donors several years after donation...
  39. ncbi Graft size alone should not affect donors selection and be used to predict the prognosis of recipients after living donor liver transplantation
    Jian Yong Lei
    Department of Liver and Vascular Surgery, Sichuan University, Chengdu, China
    Hepatogastroenterology 59:224-7. 2012
    ..This study determines whether the graft to recipient weight ratio (GRWR) alone can be used to select the liver donor and as an outcome predictor before living donor liver transplantation (LDLT)...
  40. ncbi Outcomes and pulmonary function in living lobar lung transplant donors
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    Transpl Int 25:153-7. 2012
    ..6 ± 8.9% and 89.3 ± 8.7% of the preoperative value 3, 6, and 12 months postoperatively. Living-donor lobectomy was performed with low morbidity. Pulmonary function even after lobectomy was better preserved than expected...
  41. ncbi Splenectomy does not offer immunological benefits in ABO-incompatible liver transplantation with a preoperative rituximab
    Vikram Raut
    Department of Hepatobiliary Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto, Japan
    Transplantation 93:99-105. 2012
    ..We investigated the necessity of splenectomy by retrospective analyses of the short-term anti-ABO antibody response and long-term outcomes of ABO-I LT...
  42. ncbi Living kidney donors requiring transplantation: focus on African Americans
    Eric M Gibney
    Division of Nephrology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 84:647-9. 2007
    ..We then compared the race of donors listed for kidney transplant to the race of all living donors during the same time period. Between 1993 and 2005, 8889 donors (14.3%) were AA and 42,419 (68...
  43. pmc Imprecision of creatinine-based GFR estimates in uninephric kidney donors
    Jane C Tan
    750 Welch Road, Suite 200, Palo Alto, CA 94304, USA
    Clin J Am Soc Nephrol 5:497-502. 2010
    ..The accuracy of such equations in uninephric living donors has yet to be validated...
  44. ncbi Liver allograft outcomes after laparoscopic-assisted and minimal access live donor hepatectomy for transplantation
    Arun Thenappan
    Department of Surgery, Georgetown University Hospital, Washington, DC 20007, USA
    Am J Surg 201:450-5. 2011
    ..We describe our initial experience with laparoscopic-assisted and minimal-access donor hepatectomy and its potential as a safe alternative with graft function comparable with open resection in live-donor liver transplantation...
  45. pmc Laboratory test results after living liver donation in the adult-to-adult living donor liver transplantation cohort study
    James F Trotter
    Department of Surgery, University of Colorado, Aurora, CO, USA
    Liver Transpl 17:409-17. 2011
    ..Persistently decreased platelet counts warrant further investigation...
  46. ncbi Donor outcomes after living donor liver transplantation (LDLT)
    Pongphob Intaraprasong
    Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 93:1340-3. 2010
    ....
  47. pmc Renal function equations before and after living kidney donation: a within-individual comparison of performance at different levels of renal function
    Hilde Tent
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, Netherlands
    Clin J Am Soc Nephrol 5:1960-8. 2010
    ..Whether this is due to the level of GFR as such or to differences in individual characteristics between healthy individuals and patient with chronic kidney disease (CKD) is unknown...
  48. ncbi Laparoscopic living-donor nephrectomy: analysis of the existing literature
    Francesco Greco
    Department of Urology and Kidney Transplantation, Martin Luther University, Halle Saale, Germany
    Eur Urol 58:498-509. 2010
    ..Laparoscopic living-donor nephrectomy (LLDN) has achieved a permanent place in renal transplantation and in some centers has replaced open donor nephrectomy as the standard technique...
  49. ncbi Bile leak following living donor liver transplantation: clinical efficacy of percutaneous transhepatic treatment
    Jin Hyoung Kim
    Department of Radiology, Asan Medical Center, Seoul, Korea
    Liver Transpl 14:1142-9. 2008
    ..However, further investigations are needed to minimize the duration of treatment and biliary strictures following PTBD catheter removal...
  50. ncbi Two hundred living donor kidney transplantations under alemtuzumab induction and tacrolimus monotherapy: 3-year follow-up
    H P Tan
    the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 9:355-66. 2009
    ..4% remained steroid-free from the time of transplantation. Infectious complications were uncommon. This experience suggests the 3-year efficacy of this approach...
  51. ncbi Resolution of severe graft steatosis following dual-graft living donor liver transplantation
    DeokBog Moon
    Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Liver Transpl 12:1156-60. 2006
    ..This observation is helpful in understanding the recovery sequences following transplantation of steatotic liver grafts, as well as expanding the acceptability of steatotic liver grafts...
  52. ncbi Limited benefit of biochemical response to combination therapy for patients with recurrent hepatitis C after living-donor liver transplantation
    Yoshihide Ueda
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 85:855-62. 2008
    ....
  53. pmc Comparison of laparoscopic and mini incision open donor nephrectomy: single blind, randomised controlled clinical trial
    Niels F M Kok
    Department of Surgery, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, Netherlands
    BMJ 333:221. 2006
    ..To determine the best approach for live donor nephrectomy to minimise discomfort to the donor and to provide good graft function...
  54. ncbi Cardiovascular disease and hypertension risk in living kidney donors: an analysis of health administrative data in Ontario, Canada
    Amit X Garg
    1Division of Nephrology, University of Western Ontario, London, Canada
    Transplantation 86:399-406. 2008
    ..Risk estimates in the literature are variable, and most studies did not use a healthy control group to assess outcomes attributable to donation...
  55. ncbi Emergency adult-to-adult living-donor liver transplantation for acute liver failure in a hepatitis B virus endemic area
    Soo Jung Park
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Hepatology 51:903-11. 2010
    ..03, P = 0.04) was associated with increased mortality of patients. There was no living donor mortality. Eight (17.8%) and three (6.7%) living donors experienced grade 1 and 2 complications, respectively.
  56. ncbi Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based on over 13,000 german blood donors
    Carlheinz R Müller
    Zentrales Knochenmarkspender Register für Deutschland, German National Bone Marrow Donor Registry, Ulm, Germany
    Hum Immunol 64:137-51. 2003
    ....
  57. ncbi Characterization of liver enzymes on living related liver transplantation patients with acute rejection
    King Wah Chiu
    Liver Transplant Program, Division of Hepato Gastroenterology, Chang Gung University, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan
    Hepatogastroenterology 52:1825-7. 2005
    ....
  58. ncbi Age, gender, race, and associations with kidney failure following living kidney donation
    E M Gibney
    Division of Nephrology and the Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, Virginia 23298 0274, United States
    Transplant Proc 40:1337-40. 2008
    ..We sought information on age, gender, and race of kidney donors to determine which groups were over-represented on the kidney transplant waiting list...
  59. ncbi Global trends in the rates of living kidney donation
    Lucy Diane Horvat
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Kidney Int 75:1088-98. 2009
    ..Our study shows that rates of living donor kidney transplant have steadily risen in most regions of the world, increasing its global significance as a treatment option for kidney failure...
  60. ncbi Living donor liver transplantation for hepatocellular carcinoma
    Laura Kulik
    Department of Medicine, Division of Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Gastroenterology 127:S277-82. 2004
    ....
  61. ncbi Anatomic variations in right liver living donors
    Giovanni Varotti
    Recanati Miller Transplantation Institute, Mount Sinai Hospital, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Coll Surg 198:577-82. 2004
    ..Anatomic knowledge is crucial in right liver living donor transplantation...
  62. ncbi Significance of positive cytotoxic cross-match in adult-to-adult living donor liver transplantation using small graft volume
    Kyung Suk Suh
    Department of Surgery, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Liver Transpl 8:1109-13. 2002
    ..035). In conclusion, when lymphocytotoxic cross-match and flow cytometry are significantly positive, adult-to-adult LDLT using small-for-size grafts should not be performed...
  63. ncbi Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?
    Jan J Cornelissen
    Department of Hematology, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    Blood 109:3658-66. 2007
    ....
  64. ncbi Incentive models to increase living kidney donation: encouraging without coercing
    Ajay K Israni
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Am J Transplant 5:15-20. 2005
    ..Therefore many patients are turning to living donors. We describe four models of incentives to improve rates of living kidney donation: the market compensation ..
  65. ncbi The natural history and outcome of liver transplantation in hepatitis C virus-infected recipients
    Edward Gane
    New Zealand Liver Transplant Unit, Auckland Hospital, Auckland, New Zealand
    Liver Transpl 9:S28-34. 2003
    ..The 3-year survival is <10% after the onset of hepatitis C virus-related allograft failure, compared with 60% after decompensation in immunocompetent patients...
  66. ncbi Marked Differences in acute cellular rejection rates between living-donor and deceased-donor liver transplant recipients
    Lawrence U Liu
    Recanati Miller Transplantation Institute, The Mount Sinai Medical Center, New York, NY 10029, USA
    Transplantation 80:1072-80. 2005
    ..The aims of this study were to compare the incidence of ACR between recipients of live- and deceased-donor liver transplants, and to note any differences in ACR among related and unrelated living-donor recipients...
  67. ncbi Effects of hemi-portocaval shunts for inflow modulation on the outcome of small-for-size grafts in living donor liver transplantation
    Roberto Troisi
    Department of General Surgery, Division of Hepato Biliary and Transplantation Surgery, Ghent University Hospital Medical School, Belgium
    Am J Transplant 5:1397-404. 2005
    ..Graft inflow modulation through HPCS reduces the risk of complications when transplanting SFSG in adult recipients...
  68. ncbi Noninvasive evaluation of graft steatosis in living donor liver transplantation
    Minoru Iwasaki
    Department of Transplantation and Immunology, Kyoto University Graduate School of Medicine, 54 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Transplantation 78:1501-5. 2004
    ..Liver macrovesicular steatosis in living donors was assessed using quantitative X-ray computed tomography (CT) analysis and histological examination of ..
  69. ncbi Feasibility of auxiliary partial orthotopic liver transplantation from living donors for patients with adult-onset type II citrullinemia
    Masahide Yazaki
    Third Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Liver Transpl 10:550-4. 2004
    ..In addition, APOLT can be carried out safely to overcome the limitation of graft volume in living donor liver transplantation...
  70. ncbi Disparities in the utilization of live donor renal transplantation
    J L Gore
    VA Greater Los Angeles Healthcare System, Robert Wood Johnson Clinical Scholars Program, Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Am J Transplant 9:1124-33. 2009
    ..We identified significant racial and socioeconomic disparities in the utilization of LDRT. Educational initiatives and dissemination of processes that enable increased utilization of LDRT may address these disparities...
  71. ncbi Living donor liver transplantation for hepatocellular carcinoma: Tokyo University series
    Yasuhiko Sugawara
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Dig Dis 25:310-2. 2007
    ..Our institutional guideline for HCC in LDLT has been up to 5 nodules with a maximum diameter of 5 cm (5-5 rule)...
  72. ncbi Kidney allograft fibrosis and atrophy early after living donor transplantation
    Fernando G Cosio
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Transplant 5:1130-6. 2005
    ..GIF frequently develops in the absence of risk factors. Lower GFR post-transplant identify patients at highest risk of GIF...
  73. ncbi Intention-to-treat analysis of liver transplantation for hepatocellular carcinoma: living versus deceased donor transplantation
    Prashant Bhangui
    Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, Villejuif, France
    Hepatology 53:1570-9. 2011
    ..On an intention-to-treat basis, the overall survival (OS) in the two groups was comparable. Patients beyond the Milan and UCSF criteria showed a trend toward worse outcomes with LDLT compared with DDLT (P = 0.06)...
  74. ncbi Extended indication for living donor liver transplantation in patients with hepatocellular carcinoma
    Yuji Soejima
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Transplantation 83:893-9. 2007
    ..The present study assessed the outcome of living donor liver transplantation (LDLT) under extended selection criteria based on a single-center experience...
  75. ncbi Medical risks in living kidney donors: absence of proof is not proof of absence
    Elizabeth S Ommen
    Mount Sinai Medical Center, Division of Nephrology, 1 Gustave Levy Place, Box 1243, New York, NY 10029, USA
    Clin J Am Soc Nephrol 1:885-95. 2006
    ..widespread, yet there has been little critical analysis of existing studies of long-term medical outcomes in living donors. This review analyzes issues in study design that affect the quality of the evidence and summarizes possible ..
  76. ncbi Introducing hand-assisted retroperitoneoscopic live donor nephrectomy: learning curves and development based on 413 consecutive cases in four centers
    Jonas Wadstrom
    Department of Surgery, Uppsala University Hospital, Uppsala, Sweden
    Transplantation 91:462-9. 2011
    ..This study reports on our four-center experience, development, and learning curves from the first 413 LDNs using a hand-assisted retroperitoneoscopic (HARS) technique...
  77. ncbi Individualized extension of pegylated interferon plus ribavirin therapy for recurrent hepatitis C genotype 1b after living-donor liver transplantation
    Yoshihide Ueda
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto, Japan
    Transplantation 90:661-5. 2010
    ..In this study, we designed an individualized treatment regimen with pegylated interferon and ribavirin for recurrent hepatitis C based on individual viral responses...
  78. ncbi Liver transplantation for adult patients with hepatocellular carcinoma in Korea: comparison between cadaveric donor and living donor liver transplantations
    Shin Hwang
    Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Liver Transpl 11:1265-72. 2005
    ..7%: Their 3-YSR was 88.1% after CDLT and 90.6% after LDLT. In conclusion, we think that currently available selection criteria for HCC patients can be applicable to LDLT without change of prognostic power...
  79. ncbi Effect of the use or nonuse of long-term dialysis on the subsequent survival of renal transplants from living donors
    K C Mange
    Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 344:726-31. 2001
    The effect on allograft survival of the transplantation of kidneys from living donors without the previous initiation of long-term dialysis is controversial.
  80. ncbi Adult-to-adult transplantation of the right hepatic lobe from a living donor
    James F Trotter
    Division of Gastroenterology and Hepatology, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 346:1074-82. 2002
  81. ncbi Endoscopic management of biliary complications after adult living donor liver transplantation
    Janak N Shah
    Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Am J Gastroenterol 99:1291-5. 2004
    ..We assessed the role of endoscopic retrograde cholangiopancreatography (ERCP) in the diagnosis and management of biliary complications following LDLT...
  82. ncbi Living donation decision making: recipients' concerns and educational needs
    Amy D Waterman
    Washington University School of Medicine, St Louis, MO, USA
    Prog Transplant 16:17-23. 2006
    Despite the advantages of living donor transplantation, evidence suggests that some potential recipients with living donors have psychological concerns that prevent them from pursuing living donation...
  83. pmc Fatal and nonfatal hemorrhagic complications of living kidney donation
    Amy L Friedman
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Ann Surg 243:126-30. 2006
    ....
  84. ncbi Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation
    Dao Pei Lu
    Peking University Institute of Hematology, 11 Xizhimen South Street, Beijing 100044, China
    Blood 107:3065-73. 2006
    ..In summary, HCT performed with related HLA-mismatched donors is a feasible approach with acceptable outcomes...
  85. ncbi Arteriosclerosis in kidneys from healthy live donors: comparison of wedge and needle core perioperative biopsies
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Pathology 712, Baltimore, MD 21287, USA
    Arch Pathol Lab Med 132:37-42. 2008
    ..There are many studies of histopathologic changes in deceased donor kidneys and how these changes affect subsequent graft function; most are based on wedge rather than needle core biopsies...
  86. ncbi Initial steroid bolus injection promotes vigorous CD8+ alloreactive responses toward early graft acceptance immediately after liver transplantation in humans
    Hiroto Egawa
    Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Liver Transpl 13:1262-71. 2007
    ..In conclusion, ISB must be done in place, especially in Group II with preexisting high EM T cells, to enable the development of early allograft acceptance...
  87. ncbi Older living kidney donors: surgical outcome and quality of life
    Robert C Minnee
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Transplantation 86:251-6. 2008
    ..Little is known about the quality of life (QOL) of this elderly group. The purpose of this study is to examine surgical outcome and the QOL in older living donors.
  88. ncbi Liver transplantation using grafts of living donors with isolated unconjugated hyperbilirubinemia: a matched case-control study
    Sang Bin Han
    Department of Anesthesiology and Pain Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
    Transpl Int 26:623-30. 2013
    ..Forty-six living donors with IUHB were matched 1:1 with the control donors and 43 recipients who received grafts from donors with IUHB ..
  89. ncbi Clinical significance of slow recovery of graft function in living donor kidney transplantation
    So Young Lee
    Department of Internal Medicine, Transplant Research Center, Seoul St Mary s Hospital, The Catholic University of Korea, Seocho Ku, Seoul, Korea
    Transplantation 90:38-43. 2010
    ..The clinical significance of slow recovery of graft function (SGF) in living donor kidney transplantation is unclear. We evaluated the incidence, risk factors, and clinical outcome of SGF in living donor transplantation...
  90. ncbi Living donor age and kidney transplant outcomes
    K Noppakun
    Division of Nephrology and Hypertension, Department of Internal Medicine and William von Liebig transplant Center, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 11:1279-86. 2011
    ..In conclusion, LD age is an important determinant of long-term graft survival, particularly in younger recipients. Older kidneys with reduced survival are identifiable by the development of proteinuria posttransplant...
  91. ncbi Transplant center provision of education and culturally and linguistically competent care: a national study
    E J Gordon
    Institute for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Am J Transplant 10:2701-7. 2010
    ..Transplant centers need to take greater efforts to consistently provide appropriate education, promote LD, and provide culturally and linguistically competent care to ensure effective communication with all patients...
  92. ncbi Comparative evaluation of expanded criteria for patients with hepatocellular carcinoma beyond the Milan criteria undergoing living-related donor liver transplantation
    Ken Shirabe
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Clin Transplant 25:E491-8. 2011
    ....
  93. ncbi Persistent glomerular hematuria in living kidney donors confers a risk of progressive kidney disease in donors after heminephrectomy
    R Kido
    Department of Nephrology and Endocrinology, University of Tokyo, Japan
    Am J Transplant 10:1597-604. 2010
    ..Potential donors with persistent glomerular hematuria should be excluded, while those with isolated hematuria need to be evaluated with heightened caution...
  94. pmc Living donor kidney donation: another form of white coat effect
    Stephanie S DeLoach
    Departments of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Nephrol 35:75-9. 2012
    ..Living donor nephrectomy can be associated with increases in blood pressure several years following the procedure, but the best method to assess blood pressure during the living donor evaluation process is unclear...
  95. ncbi Living liver donor death related to complications of myeloma
    Emmanuel Melloul
    Department of HPB Surgery and Liver Transplantation, Hospital Beaujon, Clichy, France
    Liver Transpl 15:326-9. 2009
    ..This unusual cause of donor death after right hepatectomy reinforces the need for an extensive preoperative assessment. We advocate the addition of urinary protein loss and electrophoresis to the standard donor assessment protocol...
  96. ncbi Documented deaths of hepatic lobe donors for living donor liver transplantation
    James F Trotter
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Liver Transpl 12:1485-8. 2006
    ....
  97. ncbi Upper midline incision for living donor right hepatectomy
    Seong Hoon Kim
    National Cancer Center, Goyang si, Gyeonggi Do, Republic of Korea
    Liver Transpl 15:193-8. 2009
    ....
  98. ncbi Adult living liver donors have excellent long-term medical outcomes: the University of Toronto liver transplant experience
    L Adcock
    Liver Transplant Program, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Am J Transplant 10:364-71. 2010
    ..This prospective study suggests that living liver donation can be performed safely without any serious late medical complications and suggests that long-term follow-up may contribute to favorable donor outcomes...
  99. ncbi Use of middle hepatic vein in right lobe living donor liver transplantation
    Murat Dayangac
    Florence Nightingale Hospital, Center for Organ Transplantation, Abide i Hurriyet Caddesi No 290 Sisli, Istanbul, Turkey
    Transpl Int 23:285-91. 2010
    ..The decision, therefore, of the extent of right lobe donor hepatectomy should be tailored to the particular conditions considering the graft quality and metabolic demand of the recipient...
  100. ncbi Short- and long-term donor morbidity in right lobe living donor liver transplantation: 91 consecutive cases in a European Center
    D Azoulay
    AP HP Hopital Paul Brousse, Centre Hepato Biliaire, Villejuif, France
    Am J Transplant 11:101-10. 2011
    ..50%; p = 0.06). In the long term, donors expressed an overall sense of well being, but some sequelae of surgery do restrain their current lifestyle. Our results warn against lackadaisical vigilance once RLLD hepatectomy becomes routine...
  101. ncbi Rescue of a living donor with liver transplantation
    B Ringe
    Department of Surgery, Division of Gastroenterology and Hepatology, Drexel University College of Medicine, Philadelphia, PA, USA
    Am J Transplant 8:1557-61. 2008
    ..Our own patient is the only survivor, so far. This case demonstrates that even in supposedly healthy living donors postoperative complications cannot be completely prevented...

Research Grants62

  1. Brief Nursing Intervention to Prevent Poor Psychosocial Outcomes in Living Donors
    Mary Amanda Dew; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Living donors constitute 46% of all organ transplant donors in the U.S...
  2. Kidney Donor Outcomes Cohort (KDOC) Study
    James R Rodrigue; Fiscal Year: 2013
    ..Maine, Rhode Island, Florida, Iowa, and Arizona) and with experience and expertise in caring for living donors and transplant recipients, will participate in the study...
  3. Novel Control Group to Expand the Scope of the RELIVE Living Kidney Donor Study
    Robert M Merion; Fiscal Year: 2013
    ..Living kidney donor data are derived from the Renal and Lung Living Donors Evaluation (RELIVE) database, containing detailed information on 8,951 living kidney donors who donated at one ..
  4. The comparative effectiveness of kidney transplantation in advanced CKD
    MORGAN ERIKA GRAMS; Fiscal Year: 2013
    ..listing and allocation, and also improve clinical decision-making for pre-dialysis transplant patients with living donors. Furthermore, identification of characteristics associated with high cardiovascular and mortality risk may be ..
  5. Right Lobe Living Donor Liver Transplantation in Adults
    PAUL HIDEYO HAYASHI; Fiscal Year: 2010
    ..The first will examine in-depth the short and long-term morbidity and quality of life of living donors. The second will examine differences in drug metabolism and immunosuppressive regimen between recipients of ..
  6. Improvement in Paired Donation Program
    Stanislaw M Stepkowski; Fiscal Year: 2013
    ..by applicant): The Alliance for Paired Donation (APD) makes possible the transplantation of kidneys from living donors who otherwise are not transplanted because of ABO blood group incompatibility and/or the presence of donor-..
  7. Quality of Informed Consent for Adult-to-Adult Living Donor Liver Transplantation
    Elisa J Gordon; Fiscal Year: 2012
    ..This tool will help to improve the informed consent process for living liver donation by identifying living donors'comprehension deficits and prompting targeted donor-clinician communication...
  8. A2ALL Cohort Study: Pyschosocial and Surgical Outcomes
    Abhinav Humar; Fiscal Year: 2013
    ..include fundamental questions regarding the impact of this procedure on the long-term health and well-being of living donors, especially beyond the 1st year postdonation...
  9. Adult to Adult Living Donor Liver Transplantation
    Robert A Fisher; Fiscal Year: 2013
    ..On 03/28/2006,1R01DK069859-01A1, Genes Related to HCC progression in living donors (LD) and deceased donors (DD) transplant (GR2HCC) was awarded to the VCU liver program director and chairman ..
  10. Approaches to Tolerance of Allogeneic Kidney and Islet Transplants
    David H Sachs; Fiscal Year: 2013
    ..transplants;2) the genetic and technical parameters required for successful composite IK transplants from living donors;and 3) the immunological mechanisms involved in tolerance of kidney, islet, and islet-kidney (IK) allografts...
  11. Adult to Adult Living Donor Liver Transplantation Cohort Study
    Jean C Emond; Fiscal Year: 2013
    ..First, a structured study of the psychiatric complications in living donors including developing predictors and determining using a control population of concurrently enrolled ..
  12. ADLDT: An Opportunity to Expand the National Donor Pool
    Johnny C Hong; Fiscal Year: 2010
    ..The living donor section will compare living donors and potential donors who do not undergo donation...
  13. New Approaches To Cardiothoracic Tolerance Induction
    Joren C Madsen; Fiscal Year: 2013
    ..approach using mixed chimerism to patients who received simultaneous kidney and bone marrow transplants from living donors. Our hypothesis is that with further mechanistic study, tolerance induced through mixed chimerism will prove ..
  14. Clinical Center - Outcomes of Live Organ Donors
    Arthur J Matas; Fiscal Year: 2010
    ..In addition, this study will be the first study of the informed consent process in relation to living donation. Information gained will be important to address and perhaps change the informed consent process for future living donors.
  15. Achieving Consensus on High Risk Donor to Improve Access to Organ Transplants
    Michael G Ison; Fiscal Year: 2011
    ..Optimal screening to mitigate risk among living donors has not been formally established and post-transplant follow-up from recipients of living or deceased donors ..
  16. A2ALL- Patient Safety System Improvements in Living Donor Liver Transplantation
    Donna M Woods; Fiscal Year: 2013
    ..Prevention of such events is especially important when caring for living donors, given that they are healthy volunteers undergoing a major procedure purely for altruistic reasons without any ..
  17. Renal senescence in kidney donors
    Jane C Tan; Fiscal Year: 2013
    ..By year 05 of this grant, I will complete recruitment into a longitudinal study of a group (N=30) of aging, living donors (>55 years). A matching group of youthful living donors (<45 years) will serve as controls...
  18. Living Donor Liver Transplant - Predictive Models for Long-Term Health Outcomes
    Michael M Abecassis; Fiscal Year: 2013
    ..Funding Opportunity Announcement objective to improve understanding of long-term health and well-being of living donors and on the efficacy of living donor liver transplantation (LDLT)...
  19. A2ALL- Patient Safety System Improvements in Living Donor Liver Transplantation
    DONNA M contact WOODS; Fiscal Year: 2010
    ..the adult-to-adult living donor liver transplantation (A2ALL) initiative in an effort to address outcomes in living donors and recipients of living donor organs...
  20. Using Systems Biology to Understand Islet Adaptation and Failure Diabetes
    Charles F Burant; Fiscal Year: 2010
    ..the techniques and tools that we develop to evaluate the funtion and metabolism of human islets isolated from living donors with known physiological status...
  21. A Program to Increase Living Donations in African Americans
    Prabhakar K Baliga; Fiscal Year: 2011
    ..We observed a three fold increase in the number of living donors but still had a 30% drop out rate (patients who did not complete evaluation after volunteering to donate)...
  22. Optimization and Simulation of Kidney Paired Donation Programs
    John D Kalbfleisch; Fiscal Year: 2013
    ..by many patients with kidney failure who present with willing, but immunologically or blood type incompatible living donors. Kidney paired donation uses a computerized algorithm to match one incompatible donor/recipient pair to ..
  23. The Increasing Kidney Disease Awareness Network (IKAN) Transplant Protect
    Bessie A Young; Fiscal Year: 2011
    ..leaders, health care providers, ESRD patients, ESRD patient family members, transplant recipients and living donors to develop content for culturally-specific transplant/CKD educational material - 2...
  24. SUPPLY, EVALUATION AND SELECTION OF LIVING RENAL DONORS
    Akinlolu Ojo; Fiscal Year: 2001
    ..only 25% of transplants performed in European Americans and 10% of transplants in African americans are from living donors. factors governing the supply of living renal donors are not well understood...
  25. Ethical Issues in Living Donor Transplantation
    Lainie Ross; Fiscal Year: 2009
    ..This research will explore the ethical and policy issues raised by transplantation with living donors. The broad objectives of the project are: 1) to examine the trend from replenishable organs (blood and bone ..
  26. Strategy to Cure Type 1 Diabetes
    Zhiguang Guo; Fiscal Year: 2003
    ..We have the capability to transplant donor-specific islets from living donors. Success in our proposed experiments, combined with our profound clinical experience, will provide a solid ..
  27. Impact of Structure on Living Organ Donation
    Rebecca Winsett; Fiscal Year: 2002
    ..effort is placed on the organizational and operational processes for identify, evaluating, and caring for living donors. As the nation turned towards CD donation, 1 transplant centers the national listing procedures so that CD ..
  28. Using MDPs to Optimize Living Donor Liver Transplants
    Mark Roberts; Fiscal Year: 2006
    Virtually unheard of prior to 1990, the use of living donors for liver transplantation has been increasing and now represents over 500 transplants per year...
  29. Magnetic Separation of Liberated Islets During Isolation
    KLEARCHOS PAPAS; Fiscal Year: 2005
    ..is expected to 1), increase threefold the number of patients rendered insulin independent from the available cadaver donor pool and 2), to permit treatment of patients with islets isolated from a hemi-pancreas from living donors.
  30. Magnetic Separation of Liberated Islets During Isolation
    JEFFREY CHALMERS; Fiscal Year: 2005
    ..is expected to 1), increase threefold the number of patients rendered insulin independent from the available cadaver donor pool and 2), to permit treatment of patients with islets isolated from a hemi-pancreas from living donors.
  31. Renal & Cellular Studies in Type 1 Diabetic Patients
    S Mauer; Fiscal Year: 2007
    ..albuminuria, (3) sibling pairs concordant for type 1 D, (4) type 1 D kidney transplant recipients and their living donors, (5) type 1 D pts with rapid development of DN who have been cured of D by successful pancreas transplant for ..
  32. Quality of Life Therapy for Adults with ESRD Awaiting Renal Transplantation
    James Rodrigue; Fiscal Year: 2007
    ..These benefits have the potential to extend the QOL outcomes otherwise derived from transplantation alone. [unreadable] [unreadable] [unreadable]..
  33. EVALUATION OF A CONCEPTUAL MODEL OF ORGAN DONATION
    James Rodrigue; Fiscal Year: 2004
    ..abstract_text> ..
  34. Predictors of Living Kidney Donor Recruitment
    Peter Reese; Fiscal Year: 2006
    ..however, on what factors predict whether potential kidney transplant recipients will be able to recruit living donors. Our project will consist of a prospective cohort study of potential transplant recipients...
  35. NEWBORN GENETIC SCREENING:FOR WHOSE BENEFIT?
    Lainie Ross; Fiscal Year: 2005
    ..OUTCOMES: The major outcomes will be a series of peer-reviewed articles and a full-length book entitled Newborn Genetic Screening: In whose Interest? For whose Benefit? ..
  36. Regulation of GnRH Neuronal Development by FGF Signaling
    John Gill; Fiscal Year: 2005
    ..Critical stages of GnRH neuron development will be evaluated in mice to discern the functional contribution of FGF signaling in this important neuroendocrine system. ..
  37. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006
    ..This work has important implications for the selective inactivation of gene function in allografts through ex vivo gene transfer. ..
  38. Race & Viral Resistance in Chronic Hepatitis C (VIRAHEP*
    Robert Brown; Fiscal Year: 2005
    ..abstract_text> ..
  39. WEB BASED RENAL TRANSPLANT PATIENT MEDICATION EDUCATION
    Amy Friedman; Fiscal Year: 2006
    ..It is hoped that better prescription comprehension and understanding of the transplant process will help patients improve their own compliance and troubleshoot errors made by other providers. ..
  40. Psychiatric Morbidity Late Post Heart Transplant
    Mary Amanda Dew; Fiscal Year: 2008
    ..Data collection will involve semi-structured interviews, Txp Program staff evaluations, and medical record reviews. ..
  41. T Cell Cytokines and Renal Allograft Survival
    Kevin Mange; Fiscal Year: 2003
    ....
  42. MAJOR DEPRESSION, ANXIETY, AND LUNG TRANSPLANTATION
    Mary Amanda Dew; Fiscal Year: 2003
    ..An ultimate aim of the analyses is to refine hypotheses about the predictive sequence of effects under investigation and thereby to revise the study's conceptual model for subsequent intervention efforts. ..
  43. NK Receptors and Bone Marrow Transplant Outcome
    Katharine Hsu; Fiscal Year: 2008
    ..Dr. Hsu intends to develop a career as an independent investigator in the field of NK cell immunogenetics and allogeneic hematopoietic stem cell transplantation. ..
  44. Live Unrelated Kidney Donor & Sibling Follow-up Study
    Bertram Kasiske; Fiscal Year: 2005
    ..Altogether, this study will provide useful information that will improve the informed consent for living kidney donors and enhance our knowledge of the role of the kidney, if any, in CVD. ..
  45. The Coronary Screening for Kidney Transplantation (COST) Study
    Bertram Kasiske; Fiscal Year: 2008
    ..The money spent on these procedures might be better directed to health care measures of proven efficacy. [unreadable] [unreadable] [unreadable]..
  46. Innate Cellular Lectin-Mediated Binding of Xenogeneic Antigens
    Michael Rees; Fiscal Year: 2009
    ..This work will advance our understanding of macrophage recognition of foreign sugars from other species and make ECLP a more useful tool in treating fulminant hepatic failure. ..
  47. Chronic Kidney Disease with Benign Prostatic Hyperplasia
    ANDREW RULE; Fiscal Year: 2004
    ..Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD. ..
  48. Genes Related to HCC Progression in LD and DD Transplant
    Robert A Fisher; Fiscal Year: 2010
    ..abstract_text> ..
  49. Long-term Outcome: Transplant for Alcohol Liver Disease
    Andrea F DiMartini; Fiscal Year: 2010
    ..We also expect to use these data to develop treatment intervention studies for the future. ..
  50. Permeability Changes in Small Bowel Allograft Rejection
    Jonathan Fryer; Fiscal Year: 2006
    ....
  51. Living Donor Information Network for Caregiving
    Laura Taylor; Fiscal Year: 2010
    ....
  52. Psychosocial Issues in Umbilical Cord Blood Donation
    Galen Switzer; Fiscal Year: 2004
    ..abstract_text> ..
  53. TECHNOLOGY USE AND PROLONGING DYING IN OLDER ADULTS
    SHARON KAUFMAN; Fiscal Year: 2002
    ..The interpretive goal is to examine why closing the gap between what health consumers say they want and what actually happens with advanced technologies is so difficult. ..
  54. A Renal Epithelial Urea Sensor
    David Cohen; Fiscal Year: 2005
    ..In addition, the sufficiency of these and related signaling elements for urea signaling will be examined in models of heterologous expression. ..
  55. Immune Parameters in a Steroid Sparing Clinical Trial
    Nancy Reinsmoen; Fiscal Year: 2005
    ..Thus, the overall study is designed to use immune parameters to identify recipients at low vs. high risk for poor graft outcome, thereby allowing for individualization of immunosuppression aimed at improving long-term graft outcome. ..
  56. Genetic/Immunological Basis of Tuberculosis and Anergy
    Julio Delgado; Fiscal Year: 2005
    ..It is anticipated that these results will be useful in the development of genetic and immune therapeutic strategies to combat tuberculosis. ..
  57. CELLULAR IMMUNOTHERAPY FOR HEMATOLOGIC MALIGNANCY
    John Levine; Fiscal Year: 2006
    ..2A. To evaluate a panel of cytokines as surrogate markers for GVHD and correlate these with clinical outcomes during the above trial. 2B. To correlate changes in minimal residual disease with clinical outcomes during the above trial. ..
  58. Ethnicity and Culture in Unrelated Stem Cell Donation
    Galen E Switzer; Fiscal Year: 2010
    ..abstract_text> ..
  59. The Role of Dendritic Cells in Renal Immune Responses
    Karl Nath; Fiscal Year: 2007
    ..Analytic tools will include flow cytometry, immunohistochemistry, immunofluorescence microscopy, morphometric analysis, cytokine/chemokine ELISA. ..
  60. Increasing Donation by Helping Recipients Ask
    Amy Waterman; Fiscal Year: 2008
    ..of my proposed research project is to increase living donation rates by assisting kidney recipients in asking living donors to donate...