tissue donors

Summary

Summary: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.

Top Publications

  1. pmc Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation
    Carmen Lefaucheur
    Département de Néphrologie et Transplantation Rénale, Hopital Saint Louis, Paris, France
    J Am Soc Nephrol 21:1398-406. 2010
  2. doi Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
  3. ncbi Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow
    Katia Mareschi
    Department of Pediatrics, Regina Margherita Children s Hospital, University of Turin, Turin, Italy
    J Cell Biochem 97:744-54. 2006
  4. doi Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads
    Patrizia Amico
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Transplantation 87:1681-8. 2009
  5. ncbi Proliferative response of corneal endothelial cells from young and older donors
    Cheng Zhu
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:1743-51. 2004
  6. doi Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant
    C Wiebe
    Department of Medicine and Immunology, University of Manitoba, Canada
    Am J Transplant 12:1157-67. 2012
  7. doi Death and organ donation: meeting the needs of multiethnic and multifaith populations
    G Randhawa
    Institute for Health Research, University of Bedfordshire, Putteridge Bury campus, Hitchin Road, Luton LU2 8LE, UK
    Br J Anaesth 108:i88-91. 2012
  8. pmc Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants
    Andrew M Cameron
    Dumont UCLA Liver Transplant Center, and Department of Surgery, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Ann Surg 243:748-53; discussion 753-5. 2006
  9. doi Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation
    Raghavan Murugan
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:1810-6. 2008
  10. doi The biopsied donor liver: incorporating macrosteatosis into high-risk donor assessment
    Austin L Spitzer
    Kaiser Permanente, Oakland Medical Center, Department of Surgery, Oakland, CA, USA
    Liver Transpl 16:874-84. 2010

Research Grants

  1. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
  2. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
  3. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
  4. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
  5. Iron-Induced Changes in Liver That Predispose to Malignancy
    Harriet C Isom; Fiscal Year: 2010
  6. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
  7. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
  8. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
  9. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
  10. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010

Detail Information

Publications391 found, 100 shown here

  1. pmc Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation
    Carmen Lefaucheur
    Département de Néphrologie et Transplantation Rénale, Hopital Saint Louis, Paris, France
    J Am Soc Nephrol 21:1398-406. 2010
    ..Quantification of HLA antibodies allows stratification of immunologic risk, which should help guide selection of acceptable grafts for sensitized patients...
  2. doi Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
    ..C4d-negative SAMR patients displayed an intermediate course between the no-SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR...
  3. ncbi Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow
    Katia Mareschi
    Department of Pediatrics, Regina Margherita Children s Hospital, University of Turin, Turin, Italy
    J Cell Biochem 97:744-54. 2006
    ..No chromosomal alteration or evidence of cellular senescence were observed in all analyzed samples. All these data suggest that MSCs can be isolated and expanded from most healthy donors, providing for an autologous source of stem cells...
  4. doi Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads
    Patrizia Amico
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Transplantation 87:1681-8. 2009
    ..The aims of this study were to investigate to which extent HLA-DSA detected by SAFB represent a risk for antibody-mediated rejection (AMR) and diminished allograft survival, and to define HLA-DSA characteristics predictive for AMR...
  5. ncbi Proliferative response of corneal endothelial cells from young and older donors
    Cheng Zhu
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:1743-51. 2004
    ....
  6. doi Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant
    C Wiebe
    Department of Medicine and Immunology, University of Manitoba, Canada
    Am J Transplant 12:1157-67. 2012
    ....
  7. doi Death and organ donation: meeting the needs of multiethnic and multifaith populations
    G Randhawa
    Institute for Health Research, University of Bedfordshire, Putteridge Bury campus, Hitchin Road, Luton LU2 8LE, UK
    Br J Anaesth 108:i88-91. 2012
    ..This should be of benefit to staff dealing closely with recently bereaved families and who will be requesting organ donation from them...
  8. pmc Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants
    Andrew M Cameron
    Dumont UCLA Liver Transplant Center, and Department of Surgery, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Ann Surg 243:748-53; discussion 753-5. 2006
    ..This work aimed to identify factors that impact survival outcomes for extended criteria donors (ECD) and developed an ECD scoring system to facilitate graft-recipient matching and optimize utilization of ECDs...
  9. doi Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation
    Raghavan Murugan
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:1810-6. 2008
    ..We test the hypothesis that increased inflammatory response is associated with fewer organs transplanted and decreased recipient survival...
  10. doi The biopsied donor liver: incorporating macrosteatosis into high-risk donor assessment
    Austin L Spitzer
    Kaiser Permanente, Oakland Medical Center, Department of Surgery, Oakland, CA, USA
    Liver Transpl 16:874-84. 2010
    ....
  11. ncbi Transmission of West Nile virus from an organ donor to four transplant recipients
    Martha Iwamoto
    Epidemic Intelligence Service, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta 30333, USA
    N Engl J Med 348:2196-203. 2003
    ..In August 2002, fever and mental-status changes developed in recipients of organs from a common donor. Transmission of West Nile virus through organ transplantation was suspected...
  12. pmc Surveillance of alloantibodies after transplantation identifies the risk of chronic rejection
    Pamela M Kimball
    Department of Transplant Surgery, Virginia Commonwealth University Health Systems, Richmond, Virginia 23219, USA
    Kidney Int 79:1131-7. 2011
    ..Thus, systematic assessment of longitudinal changes in alloantibody levels, either by FCXM or solid-phase assay, can help identify patients at greater risk of developing CR...
  13. doi Favorable short-term outcome of transplanted hearts selected from marginal donors by pharmacological stress echocardiography
    Tonino Bombardini
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Am Soc Echocardiogr 24:353-62. 2011
    ..The aim of this study was to establish the feasibility of an approach based on pharmacologic stress echocardiography as a gatekeeper for extended heart donor criteria...
  14. doi Two decades after legislation on identifiable donors in Sweden: are recipient couples ready to be open about using gamete donation?
    S Isaksson
    Department of Public Health and Caring Sciences, Uppsala University, S 751 22 Uppsala, Sweden
    Hum Reprod 26:853-60. 2011
    ..Recipient couples may benefit from more information and support regarding parenthood after gamete donation. Further studies are required to follow-up on the future parents' actual disclosure behaviour directed to offspring...
  15. ncbi Descemet's stripping with endothelial keratoplasty in 200 eyes: Early challenges and techniques to enhance donor adherence
    Francis W Price
    Price Vision Group, Indianapolis, Indiana, USA
    J Cataract Refract Surg 32:411-8. 2006
    ..To describe early challenges and techniques to promote donor tissue adherence in Descemet's stripping with endothelial keratoplasty (DSEK)...
  16. doi Estimating unbiased haplotype frequencies from stem cell donor samples typed at heterogeneous resolutions: a practical study based on over 1 million German donors
    H P Eberhard
    ZKRD Zentrales Knochenmarkspender Register für Deutschland, German National Bone Marrow Donor Registry, Ulm, Germany
    Tissue Antigens 76:352-61. 2010
    ..We discuss algorithmic aspects of this approach and, also because of the sample size, provide some new insights into the distribution of HLA-DRB1 alleles in the German population and the application of HFs in unrelated donor search...
  17. doi Community preferences for the allocation of solid organs for transplantation: a systematic review
    Allison Tong
    Centre for Kidney Research, The Children s Hospital at Westmead, Sydney, NSW 2145, Australia
    Transplantation 89:796-805. 2010
    ..This systematic review aimed to ascertain community preferences for organ allocation and the principles underpinning these preferences...
  18. doi For love or money? The saga of Korean women who provided eggs for embryonic stem cell research
    Francoise Baylis
    Novel Tech Ethics, Dalhousie University, 1234 Le Marchant Street, Halifax, NS B3H3P7, Canada
    Theor Med Bioeth 30:385-96. 2009
    ..This paper summarizes the Hwang debacle with particular attention to the egg scandal and ends with some preliminary thoughts on patriotism as a motive for research participation...
  19. pmc Focal C4d+ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival
    R L Kedainis
    Department of Internal Medicine, Renal Division, Washington University, St Louis, MO, USA
    Am J Transplant 9:812-9. 2009
    ..There was a clear trend toward worse graft survival in patients with focal C4d+ in this time interval, but focal C4d+ compared to both diffuse C4d+ and C4d-groups was not statistically significant (p = 0.08)...
  20. doi Incidence and impact of de novo donor-specific alloantibody in primary renal allografts
    Matthew J Everly
    Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA
    Transplantation 95:410-7. 2013
    ..This report details the dnDSA incidence and actual 3-year post-dnDSA graft outcomes...
  21. ncbi Effect of donor age on morphologic variation of cultured human corneal endothelial cells
    K Miyata
    Miyata Eye Hospital, Miyakonojo, Japan
    Cornea 20:59-63. 2001
    ..935, p = 0.0007). CONCLUSION: Cultured HCEC established from older donor tissue display greater heterogeneity. The use of HCEC from younger donors may be preferable to maximize the benefits of HCEC transplantation...
  22. doi Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patients
    Ella M van den Berg-Loonen
    University Hospital Maastricht, The Netherlands
    Transplantation 85:1086-90. 2008
    ..The standard crossmatch in the AM program is based on complement-dependent cytotoxicity...
  23. doi Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation
    Christian Koppelstaetter
    Division of Nephrology, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
    Aging Cell 7:491-7. 2008
    ..We conclude that the molecular aging marker CDKN2A in combination with chronological donor age predict renal allograft function after 1 year significantly better than chronological donor age alone...
  24. doi Neutrophil gelatinase-associated lipocalin and cystatin C could predict renal outcome in patients undergoing kidney allograft transplantation: a prospective study
    U Lebkowska
    Department of Radiology, Medical University, Bialystok, Poland
    Transplant Proc 41:154-7. 2009
    ..Therefore, NGAL needs to be investigated as a potential early marker for delayed graft function, especially in the settings of early dialysis treatment or antirejection therapy...
  25. ncbi Descemet membrane endothelial keratoplasty (DMEK)
    Gerrit R J Melles
    Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands
    Cornea 25:987-90. 2006
    ..To describe Descemet membrane endothelial keratoplasty (DMEK) with organ cultured Descemet membrane (DM) in a human cadaver eye model and a patient with Fuchs endothelial dystrophy...
  26. ncbi Gene expression in donor corneal endothelium
    John D Gottsch
    Center for Corneal Genetics, The Wilmer Eye Institute, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Ophthalmol 121:252-8. 2003
    ..To report gene expression profiles of normal human corneal endothelium with microarray analysis and serial analysis of gene expression (SAGE)...
  27. ncbi Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome
    Judith E Worthington
    Transplantation Laboratory, Manchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    Transplantation 75:1034-40. 2003
    ..This study aimed to determine whether the production, in renal transplant recipients, of antibodies directed against donor HLA mismatches is predictive of transplant failure...
  28. doi Urine neutrophil gelatinase-associated lipocalin is a marker of graft recovery after kidney transplantation
    Maria E Hollmen
    Division of Transplantation, Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    Kidney Int 79:89-98. 2011
    ..NGAL did not correlate with long-term function in DGF. Hence, day 1 urinary NGAL predicted DGF even when it was not clinically expected early on, and importantly, it predicted prolonged DGF that led to worse graft survival...
  29. ncbi Chimerism of the transplanted heart
    Federico Quaini
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    N Engl J Med 346:5-15. 2002
    ..The Y chromosome can be used to detect migrated undifferentiated cells expressing stem-cell antigens and to discriminate between primitive cells derived from the recipient and those derived from the donor...
  30. doi Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death
    Jürgen Treckmann
    Clinic for General, Visceral and Transplantation Surgery, University Hospital Essen, Hufelandstrasse 55, Germany
    Transpl Int 24:548-54. 2011
    ..3% vs. 80.2%, P=0.02). In the present study, MP preservation clearly reduced the risk of DGF and improved 1-year graft survival and function in ECD kidneys. (Current Controlled Trials number: ISRCTN83876362)...
  31. ncbi Allocation of deceased donor kidneys for transplantation: opinions of patients with CKD
    Colin C Geddes
    Renal Unit, Western Infirmary, University of Glasgow, Scotland
    Am J Kidney Dis 46:949-56. 2005
    ..The aim of this single-center survey is to seek patient opinion about the relative importance of factors used to determine the optimal transplant recipient in kidney allocation schemes...
  32. pmc Beta-cell replication is increased in donor organs from young patients after prolonged life support
    Peter In't Veld
    Diabetes Research Center and JDRF Center for Beta Cell Therapyin Diabetes, Vrije Universiteit Brussel, Brussels, Belgiumin
    Diabetes 59:1702-8. 2010
    ..This study assesses beta-cell replication in human donor organs and examines possible influences of the preterminal clinical conditions...
  33. pmc Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation
    Ann M Leen
    Center for Cell and Gene Therapy and Departments of Pediatrics, Immunology, Medicine, and Virology, Baylor College of Medicine, Texas Children s Hospital and The Methodist Hospital, Houston, TX 77030, USA
    Blood 114:4283-92. 2009
    ..This trial was registered at www.clinicaltrials.gov as #NCT00590083...
  34. ncbi Transmission of rabies virus from an organ donor to four transplant recipients
    Arjun Srinivasan
    Division of Healthcare Quality Promotion, National Center for Infectious Diseases, and the Epidemic Intelligence Service Branch, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 352:1103-11. 2005
    ..In 2004, four recipients of kidneys, a liver, and an arterial segment from a common organ donor died of encephalitis of an unknown cause...
  35. doi Comparison of posterior lamellar keratoplasty techniques to penetrating keratoplasty
    Irit Bahar
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Ophthalmology 115:1525-33. 2008
    ....
  36. doi Current situation of donation after circulatory death in European countries
    Beatriz Dominguez-Gil
    Organizacion Nacional de Trasplantes, Madrid, Spain
    Transpl Int 24:676-86. 2011
    ..The degree of utilization of DCD is lower compared with DBD. Short-term results of DCD are promising with differences between kidney recipients transplanted from controlled versus uncontrolled DCD, an observation to be further analyzed...
  37. pmc Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft's preservation and function: the ying and the yang
    Daniel Azoulay
    Centre Hepato Biliaire, Département de Chirurgie Hépato Biliaire, Hopital Paul Brousse, Villejuif, France
    Ann Surg 242:133-9. 2005
    ..Although extensively studied in animal models, ischemic preconditioning has not yet been studied in clinical transplantation...
  38. ncbi The utility of marginal donors in liver transplantation
    Ronald W Busuttil
    Department of Surgery, Division of Liver and Pancreas Transplantation, Dumont UCLA Transplant Center, Los Angeles, CA 90095, USA
    Liver Transpl 9:651-63. 2003
    ..Finally, new strategies for improving the function of the marginal/expanded donor liver will be reviewed...
  39. ncbi Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells
    Fiona J Clark
    Department of Hematology, Institute of Cancer Studies, University of Birmingham, Edgbaston, United Kingdom
    Blood 103:2410-6. 2004
    ..These results indicate that chronic graft-versus-host injury does not occur as a result of Treg cell deficiency...
  40. doi Sources of stem cells for regenerative medicine
    JENNIFER HIPP
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157, USA
    Stem Cell Rev 4:3-11. 2008
    ..We also discuss the use of amniotic-fluid derived stem cells (AFS) for potential patient-specific therapies...
  41. doi Use of intraoperative fourier-domain anterior segment optical coherence tomography during descemet stripping endothelial keratoplasty
    Pascal B Knecht
    University Hospital Zurich, Department of Ophthalmology, Frauenklinikstrasse 24, Zurich, Switzerland
    Am J Ophthalmol 150:360-365.e2. 2010
    ..To evaluate the intraoperative use of handheld Fourier-domain optical coherence tomography (OCT) during Descemet stripping automated endothelial keratoplasty (DSAEK) to assess the donor-host interface...
  42. doi Organ shortage crisis: problems and possible solutions
    G M Abouna
    Drexel University, College of Medicine, Philadelphia, Pennsylvania, USA
    Transplant Proc 40:34-8. 2008
    ....
  43. ncbi Characteristics associated with liver graft failure: the concept of a donor risk index
    S Feng
    Department of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, California, USA
    Am J Transplant 6:783-90. 2006
    ..Quantitative assessment of the risk of donor liver graft failure using a donor risk index is useful to inform the process of organ acceptance...
  44. doi [Current developments in liver transplantation in Germany: MELD-based organ allocation and incentives for transplant centres]
    H J Schlitt
    Klinik und Poliklinik für Chirurgie, Universitatsklinikum Regensburg
    Z Gastroenterol 49:30-8. 2011
    ....
  45. doi De novo DQ donor-specific antibodies are associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy
    Michelle Willicombe
    Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, UK
    Transplantation 94:172-7. 2012
    ..The aim of this study was to establish the incidence and outcomes after the development of DQ DSAbs along with the impact of class II HLA mismatch on their development...
  46. ncbi A review of family donor constructs: current research and future directions
    Olga van den Akker
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Hum Reprod Update 12:91-101. 2006
    ....
  47. doi The introduction of MELD-based organ allocation impacts 3-month survival after liver transplantation by influencing pretransplant patient characteristics
    Tobias J Weismüller
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Transpl Int 22:970-8. 2009
    ..Reduced 3-month survival was associated with longer surgery duration, higher creatinine and urea likely reflecting higher recipient morbidity. Survival probability should be incorporated into MELD-based graft allocation...
  48. ncbi Donor characteristics associated with reduced graft survival: an approach to expanding the pool of kidney donors
    Friedrich K Port
    Scientific Registry of Transplant Recipients, University Renal Research and Education Association URREA, Ann Arbor, MI 48103, USA
    Transplantation 74:1281-6. 2002
    ..Availability of cadaveric kidneys for transplantation is far below the growing need, leading to longer waiting time and more deaths while waiting...
  49. ncbi Aggressive organ donor management significantly increases the number of organs available for transplantation
    Ali Salim
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Trauma 58:991-4. 2005
    ..With no foreseeable increase in the number of donors, it is necessary to maximize the utilization of organs from the existing donor pool...
  50. ncbi Attitudes among sperm donors in 1992 and 2002: a Danish questionnaire survey
    Erik Ernst
    Department of Gynaecology and Obstetrics, Skejby Sygehus, University Hospital of Aarhus, Denmark
    Acta Obstet Gynecol Scand 86:327-33. 2007
    ..The objective is to investigate the likely consequences of abolishing anonymous sperm donation in Denmark...
  51. doi Is the increase in DCD organ donors in the United Kingdom contributing to a decline in DBD donors?
    Dominic M Summers
    Department of Surgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Transplantation 90:1506-10. 2010
    ..We sought to understand the reasons for the decline in DBD and determine whether the increase in DCD was a major factor...
  52. doi High-resolution human leukocyte antigen allele and haplotype frequencies of the Polish population based on 20,653 stem cell donors
    Alexander H Schmidt
    DKMS German Bone Marrow Donor Center, Tubingen, Germany
    Hum Immunol 72:558-65. 2011
    ..3 million additional German donors...
  53. doi Donor risk index and MELD interactions in predicting long-term graft survival: a single-centre experience
    Glenn K Bonney
    Department of Hepatobiliary and Transplantation Surgery, St James Unviersity Hospital, Leeds, United Kingdom
    Transplantation 87:1858-63. 2009
    ..We evaluated the effect of the DRI and model for end-stage liver disease (MELD) score on liver transplant recipients from a single center in the United Kingdom...
  54. doi A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors
    Peter S Macdonald
    Heart and Lung Transplant Unit, St Vincent s Hospital, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia
    Crit Care Med 40:1635-44. 2012
    ..To review all published clinical studies of thyroid hormone administration to brain-dead potential organ donors...
  55. doi Clinical relevance of preformed C4d-fixing and non-C4d-fixing HLA single antigen reactivity in renal allograft recipients
    Markus Wahrmann
    Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Transpl Int 22:982-9. 2009
    ..Possibly as a result of intensified immunosuppression in presensitized recipients, identification of C4d-fixing DSA was not associated with a further increase of rejection and graft loss rates...
  56. doi Balancing donor and recipient risk factors in liver transplantation: the value of D-MELD with particular reference to HCV recipients
    A W Avolio
    General Surgery and Transplantation Unit, Department of Surgery, A Gemelli Hospital, Catholic University, Rome, Italy
    Am J Transplant 11:2724-36. 2011
    ..The 5yrsPS<50% cutoff was identified only in HCV patients (D-MELD ≥ 1750). The innovative approach offered by D-MELD and covariates is helpful in predicting outcome after liver transplantation, especially in HCV recipients...
  57. doi Assessment of the potential heart donor: a role for biomarkers?
    Vamsidhar B Dronavalli
    Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham B15 2TH, United Kingdom
    J Am Coll Cardiol 56:352-61. 2010
    ..Cardiac troponins, cytokines, inflammatory markers, natriuretic peptides, and intracellular proteins may each have discriminant value. This review details the current status of biomarkers in the assessment of donor hearts...
  58. ncbi The role of major histocompatibility complex class I chain-related gene A antibodies in organ transplantation
    Yizhou Zou
    Transplantation Immunology Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390 8886, USA
    Curr Opin Organ Transplant 14:414-8. 2009
    ..Methods for detection of these antibodies have become available. In the 15th International Histocompatibility Workshop, a study for MICA antibody testing and of MICA genotyping was organized...
  59. doi Systemic complement activation in deceased donors is associated with acute rejection after renal transplantation in the recipient
    Jeffrey Damman
    Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 92:163-9. 2011
    ..In this study, we analyzed the effect of systemic complement activation in deceased donors before transplantation of their kidneys on posttransplant outcome in the recipient...
  60. doi Personality characteristics in a Swedish national sample of identifiable oocyte donors
    G Sydsjo
    Division of Obstetrics and Gynaecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Linkoping
    BJOG 118:1067-72. 2011
    ..To study the personality characteristics of identifiable oocyte donors in a national sample in comparison with normal values...
  61. ncbi A surgical technique for posterior lamellar keratoplasty
    G R Melles
    Rotterdam Eye Hospital, Rotterdam, The Netherlands
    Cornea 17:618-26. 1998
    ..To design a surgical technique for transplantation of posterior corneal tissue, while leaving the recipient anterior cornea intact...
  62. doi Unique splicing pattern of the TCF7L2 gene in human pancreatic islets
    P Osmark
    Department of Clinical Sciences, CRC Malmö University Hospital, Lund University, Malmo, Sweden
    Diabetologia 52:850-4. 2009
    ..Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored...
  63. doi Impact of interleukin-10 gene polymorphisms on tacrolimus dosing requirements in Chinese liver transplant patients during the early posttransplantation period
    Xiaoqing Zhang
    Department of Pharmacy, Shanghai First People s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China
    Eur J Clin Pharmacol 67:803-13. 2011
    ..In this study, we examined the IL-10 genotypes of both recipients and donors to clarify the influence of these genetic variants on tacrolimus dose requirements and pharmacokinetics...
  64. doi The effect of normothermic recirculation before cold preservation on post-transplant injury of ischemically damaged donor kidneys
    Cyril Moers
    Surgery Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transpl Int 25:210-7. 2012
    ..We found that NR had no significant influence on any of these markers. Therefore, we conclude that this animal study by no means supports the presumed beneficial effect of NR on kidneys that have been severely damaged by warm ischemia...
  65. pmc Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients
    Wendi Zhou
    Department of Virology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
    Blood 113:6465-76. 2009
    ..These results highlight the benefit of D(+) donors in improving outcomes of R(+) HCT recipients by reducing the duration and recurrent need of antiviral treatment, aided by increased levels of multifunctional CMV-specific T cells...
  66. doi Normothermic kidney preservation
    Sarah A Hosgood
    Department of Infection, Immunity and Inflammation, Transplant Group, University of Leicester, Leicester General Hospital, Leicester, UK
    Curr Opin Organ Transplant 16:169-73. 2011
    ..Normothermic preservation can be adapted to improve the quality of kidneys for transplantation by a variety of techniques...
  67. doi An update on donor-derived disease transmission in organ transplantation
    M G Ison
    Divisions of Infectious Diseases and Organ Transplantation, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Am J Transplant 11:1123-30. 2011
    ..As the epidemiology of donor-derived disease transmission has become better understood, several groups have been working on methods to further mitigate this risk...
  68. doi Estimated risk of human immunodeficiency virus and hepatitis C virus infection among potential organ donors from 17 organ procurement organizations in the United States
    K Ellingson
    Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, GA, USA
    Am J Transplant 11:1201-8. 2011
    ..Projected estimates of undetected infection with NAT screening versus serology alone suggest that NAT screening could significantly reduce the rate of undetected HCV for all donor risk strata...
  69. doi The case of biobank with the law: between a legal and scientific fiction
    Judit Sandor
    Center for Ethics and Law in Biomedicine, Central European University Budapest, Budapest, Hungary
    J Med Ethics 38:347-50. 2012
    ..deliberately pull science to the territory of a new, ambiguous commercial field? In other words, do biobanks constitute a medico-legal fiction or are they substantively different from other biomedical research protocols on human tissues?..
  70. doi Reduced frequency of regulatory T cells in peripheral blood stem cell compared to bone marrow transplantations
    Céline Blache
    INSERM U905, Faculte de Medecine, 22 Boulevard Gambetta, Rouen, France
    Biol Blood Marrow Transplant 16:430-4. 2010
    ..Although higher T cell numbers are infused in PBSCT than in BMT, it is possible that the reduced Treg content of PBSC transplants may represent 1 factor contributing to the higher risk of GVHD reported after PBSCT...
  71. doi Lectin complement pathway gene profile of the donor and recipient does not influence graft outcome after kidney transplantation
    Jeffrey Damman
    Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Mol Immunol 50:1-8. 2012
    ..This study shows that the genetic profile of the lectin pathway of complement activation of the donor and recipient is not associated with allograft outcome after kidney transplantation...
  72. doi The organ donor crisis: the missed organ donor potential from the accident and emergency departments
    P Aubrey
    Regional Donor Transplant Coordinator for North Thames Region, London, UK
    Transplant Proc 40:1008-11. 2008
    ..from colleagues working in the A&E department who suggested that there was a potential pool of organ and tissue donors that were not being realized...
  73. ncbi Endometrial endothelial cells are derived from donor stem cells in a bone marrow transplant recipient
    M Mints
    Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Hum Reprod 23:139-43. 2008
    ..We studied if male EC could be detected in the endometrial blood vessels of female human or mouse recipients of haematological stem cells from male donors...
  74. pmc An improved spinning lens test to determine the stiffness of the human lens
    H J Burd
    Department of Engineering Science, University of Oxford, Parks Road, Oxford, OX1 3PJ, UK
    Exp Eye Res 92:28-39. 2011
    ..A numerical optimisation procedure is used to determine the stiffness parameters that provide a best fit between the finite element model and the experimental data. Sample results are presented for a human lens of age 33 years...
  75. pmc CUBN as a novel locus for end-stage renal disease: insights from renal transplantation
    Anna Reznichenko
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e36512. 2012
    ..Thus, we identified CUBN rs7918972 as a novel risk variant for renal function loss in two independent settings: ESRD in native kidneys and GF in transplanted kidneys...
  76. doi Turning residual human biological materials into research collections: playing with consent
    Eugenijus Gefenas
    Department of Medical History and Ethics, Vilnius University, M K Ciurlionio St 21 27, Vilnius LT 03101, Lithuania
    J Med Ethics 38:351-5. 2012
    ..However, such precautionary consent should not be construed as blanket, unrestricted consent for any future use...
  77. doi Nucleic acid testing (NAT) of organ donors: is the 'best' test the right test? A consensus conference report
    A Humar
    Transplant Infectious Diseases, University of Alberta
    Am J Transplant 10:889-99. 2010
    ..the risk of death while awaiting transplantation make organ donor screening different from screening blood-or tissue donors. In donors with no identified risk factors, there is insufficient evidence to recommend routine NAT, as the ..
  78. ncbi Liver transplant using donors after unexpected cardiac death: novel preservation protocol and acceptance criteria
    C Fondevila
    Department of Surgery, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, 08036 Barcelona, Spain
    Am J Transplant 7:1849-55. 2007
    ..Though considered marginal, unexpected DCD can represent an important source of viable livers for transplant if strict acceptance criteria are employed and they are maintained with NECMO prior to recovery...
  79. doi Superior preservation of DCD livers with continuous normothermic perfusion
    Constantino Fondevila
    Departments of Surgery, Institut de Malaties Digestives, Hospital Clinic CIBEREHD, IDIBAPS, University of Barcelona, Barcelona, Spain
    Ann Surg 254:1000-7. 2011
    ..The objective of this study was to determine whether ex vivo normothermic machine perfusion (NMP) improves upon the benefits of NECMO in a large-animal model of unexpected DCD liver transplant...
  80. doi Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival
    George Vlad
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Hum Immunol 70:589-94. 2009
    ..Nevertheless, SPA and FCXM are invaluable tools, assisting clinicians in gauging AMR risk and tailoring immunosuppression of the posttransplantation immunological monitoring accordingly...
  81. pmc Composite tissue transplantation: a rapidly advancing field
    K V Ravindra
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    Transplant Proc 40:1237-48. 2008
    ..Additionally, some important hurdles that must be overcome in using bone marrow chimerism to induce tolerance to CTA are also discussed...
  82. doi Donors perceptions of consent to and feedback from biobank research: time to acknowledge diversity?
    K Hoeyer
    University of Copenhagen, Department of Public Health, Copenhagen, Denmark
    Public Health Genomics 13:345-52. 2010
    ..Many studies have explored public perspectives on when and how to provide informed consent to biobank research and when to get feedback on research results. Little has been done to explore overarching trends in these studies...
  83. doi Liver grafts from anti-hepatitis B core positive donors: a systematic review
    Evangelos Cholongitas
    The Royal Free Sheila Sherlock Liver Centre and University, Department of Surgery, Royal Free Hospital, London, UK
    J Hepatol 52:272-9. 2010
    ..We systematically evaluated the risk of HBV infection after liver transplantation with such grafts and the effect of anti-HBV prophylaxis...
  84. doi Monitoring the international use of unrelated donors for transplantation: the WMDA annual reports
    L M Foeken
    World Marrow Donor Association, Leiden, The Netherlands
    Bone Marrow Transplant 45:811-8. 2010
    ..In 2008, 3529 cord blood products were provided from 21 countries. Although the number of BM donations has been stable over the past 10 years, donations of PBSCs and umbilical cord blood are increasing...
  85. ncbi Thrombin inhibition during kidney ischemia-reperfusion reduces chronic graft inflammation and tubular atrophy
    Raphael Thuillier
    Inserm U927, Ischémie Reperfusion en Transplantation Rénale Université de Poitiers Faculté de Medecine et de Pharmacie, Poitiers, France
    Transplantation 90:612-21. 2010
    ..Because these organs are particularly sensitive to IRI, there is a need for novel preservation paradigms. We assessed the effect of anticoagulation therapy during graft preservation on IRI and graft outcome...
  86. doi Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program Registry
    Stephen Spellman
    National Marrow Donor Program, Minneapolis, Minnesota 55413, USA
    Biol Blood Marrow Transplant 14:37-44. 2008
  87. pmc Anti-thrombin therapy during warm ischemia and cold preservation prevents chronic kidney graft fibrosis in a DCD model
    F Favreau
    Inserm U927, Ischémie reperfusion en transplantation rénale, Poitiers, France
    Am J Transplant 10:30-9. 2010
    ..Finally, expression of oxidative stress markers Nox2 and iNOS was reduced. We conclude that inhibition of thrombin is an effective therapy against IRI that reduces chronic graft fibrosis, with a significantly positive effect on survival...
  88. doi Estimation of high-resolution HLA-A, -B, -C, -DRB1 allele and haplotype frequencies based on 8862 German stem cell donors and implications for strategic donor registry planning
    Alexander H Schmidt
    DKMS German Bone Marrow Donor Center, Tubingen, Germany
    Hum Immunol 70:895-902. 2009
    ....
  89. ncbi Ethical incentives--not payment--for organ donation
    Francis L Delmonico
    Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 346:2002-5. 2002
  90. ncbi Should donors be allowed to give broad consent to future biobank research?
    Mats G Hansson
    Centre for Bioethics at Karolinska Institute and Uppsala University, Uppsala, Sweden
    Lancet Oncol 7:266-9. 2006
    ....
  91. doi Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview
    Gary S L Peh
    Singapore Eye Research Institute, Singapore
    Transplantation 91:811-9. 2011
    ..A successful combination of tissue-engineered human corneal endothelium coupled with innovative and groundbreaking surgical procedures will bridge basic research involving cultured HCECs, bringing it from bench to bedside...
  92. doi Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantation
    J M Gloor
    Division of Nephrology and Hypertension and Transplant Center, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Transplant 10:582-9. 2010
    ..With current protocols, very high baseline DSA patients have high rates of AMR and poor long-term allograft survival highlighting the need for improved therapy for these candidates...
  93. doi Liver transplantation in the United States, 1999-2008
    P J Thuluvath
    Mercy Medical Center, Baltimore, MD, USA
    Am J Transplant 10:1003-19. 2010
    ..In addition to a general summary, we have included a more detailed analysis of liver transplantation for hepatitis C, retransplantation and SLK transplantation...
  94. doi Acceptable donor-specific antibody levels allowing for successful deceased and living donor kidney transplantation after desensitization therapy
    Nancy L Reinsmoen
    HLA Laboratory, Cedars Sinai Medical Center, 8723 Alden Drive, SSB 197, Los Angeles, CA 90048, USA
    Transplantation 86:820-5. 2008
    ....
  95. ncbi Outcomes in cardiac transplant recipients using allografts from older donors versus mortality on the transplant waiting list; Implications for donor selection criteria
    Katherine Lietz
    Division of Cardiothoracic Surgery, Columbia Presbyterian Medical Center, Columbia University, New York, New York 10032, USA
    J Am Coll Cardiol 43:1553-61. 2004
    ..This study investigates the outcomes of cardiac transplantation using older donors...
  96. pmc Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
    C Ling
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, CRC, 205 02 Malmo, Sweden
    Diabetologia 51:615-22. 2008
    ..We also tested if experimental downregulation of PPARGC1A expression in human islets influenced insulin secretion...
  97. ncbi Differential macular and peripheral expression of bestrophin in human eyes and its implication for best disease
    Robert F Mullins
    Carver Family Center for Macular Degeneration, Department of Ophthalmology and Visual Science, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Invest Ophthalmol Vis Sci 48:3372-80. 2007
    ..The nature of the vitelliform material and the reason the development of such lesions is usually restricted to the macula are two unsolved questions in the pathogenesis of this disorder...
  98. ncbi Amniotic membrane as a carrier for cultivated human corneal endothelial cell transplantation
    Yutaka Ishino
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 45:800-6. 2004
    ..To achieve this, a matrix that can serve as a carrier for cHCECs is needed. The present study was conducted to examine the feasibility of using amniotic membrane (AM) as a carrier for this application...
  99. ncbi Donor-derived hematopoietic cells in organ transplantation: a major step toward allograft tolerance?
    Gerard Rifle
    Department of Nephrology Intensive Care Transplantation, Hopital du Bocage, 2 Boulevard de Lattre de Tassigny, 21034 Dijon, France
    Transplantation 75:3S-7S. 2003
    ..The first clinical trials would appear to indicate that tolerance induction in humans using donor-derived cells is a relatively safe solution that is both promising and realistic...
  100. ncbi Diminishing significance of HLA matching in kidney transplantation
    Xuanming Su
    Graduate School of Business, Stanford University, Palo Alto, CA, USA
    Am J Transplant 4:1501-8. 2004
    ..Non-immunologic factors continue to impede more marked improvements in long-term graft survival. Recognizing these trends, organ allocation algorithms may need to be revised...
  101. ncbi Normothermic recirculation reduces primary graft dysfunction of kidneys obtained from non-heart-beating donors
    R Valero
    Department of Anaesthesiology, Hospital Clinic de Barcelona, Spain
    Transpl Int 13:303-10. 2000
    ..01). Duration of DGF was shorter in kidneys obtained through TBC than in kidneys obtained with ISP (P < 0.05). In conclusion, NR reduces the incidence of DGF and may be considered the method of choice for kidney procurement from NHBD...

Research Grants80

  1. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..In addition to human plasma and human plasma proteins such as fibrinogen, the developed technology will also be applicable to recombinant therapeutics, monoclonal antibodies, transgenics and vaccines. ..
  2. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..Furthermore, MSC administration may constitute a safe and effective way to reverse rejection episodes. ..
  3. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    ..Results of these studies may yield new information for setting guidelines for pregnant and lactating women that may protect offspring from enhanced susceptibility to these metabolic diseases. ..
  4. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ....
  5. Iron-Induced Changes in Liver That Predispose to Malignancy
    Harriet C Isom; Fiscal Year: 2010
    ....
  6. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ....
  7. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
    ....
  8. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..In this proposal, we intend to develop, using an animal model, adjunctive therapies based on nitric oxide restoration and/or heme detoxification that can be potentially translated into clinical use. ..
  9. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..abstract_text> ..
  10. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ....
  11. Improving Epigenetic-based Cell Reprogramming with Proteasome Inhibition
    Jaroslaw Staszkiewicz; Fiscal Year: 2011
    ....
  12. Epigenetic Analysis of iPS Cell Models of Aging and Alzheimer's Disease
    Bruce A Yankner; Fiscal Year: 2010
    ..This study will determine if neurons derived from induced progenitor stem cells can serve as a model to study the role of epigenetics in aging and AD, providing a new level of analysis of the human brain in health and disease. ..
  13. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..The results will potentially benefit tens of millions of patients suffering from severely damaged vascular or nervous systems, heart, kidneys, liver, skeleton, bladder, or other organs. ..
  14. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ....
  15. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    ..Such people require increased medical care and hospitalization, impacting public health primarily in economic terms. Our studies will attempt to define the basis of this immune decline and strategies to correct it. ..
  16. Maternal One Carbon Metabolism and Low Birth Weight Infant
    Satish C Kalhan; Fiscal Year: 2013
    ..There are major public health and economic implications for this study, when one considers the enormous magnitude of the LBW, the associated clinical problems and the economic burden to the society. ..
  17. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2012
    ..abstract_text> ..
  18. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..We will test this agent in a clinically-relevant small animal model and determine the most effective dose, in anticipation of definitive large animal studies to confirm its efficacy and safety. ..
  19. Iron, NO, and Lipid Peroxide in Photodynamic Therapy
    ALBERT GIROTTI; Fiscal Year: 2013
    ..abstract_text> ..
  20. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..Thus, this work will accelerate the discovery of novel therapies for this costly and deadly disease. ..
  21. Double Humanization of Liver and Blood in Mice
    ELIZABETH MARIE WILSON; Fiscal Year: 2012
    ....
  22. Development of Novel LANCL2-based Anti-diabetic Compounds
    JOSEP BASSAGANYA; Fiscal Year: 2013
    ..3 million estimated to be over $12.5 Billion for prescription medication costs alone annually in the US. ..
  23. Model of the Human Testis for Reproductive Toxicology
    PAUL JACOB TUREK; Fiscal Year: 2011
    ....
  24. cGMP-dependent Protein Kinase Function in Osteoblast Mechanotransduction
    Renate B Pilz; Fiscal Year: 2013
    ..These studies will provide the foundation for novel and improved treatment strategies in osteoporosis. ..
  25. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..We are developing a novel drug that specifically blocks the inflammatory process in this condition. We will test this agent in a series of clinically-relevant animal models of autoimmune colitis. ..
  26. Stem cell mutagenesis mediated by age and niche
    VIVIENNE ILONA REBEL; Fiscal Year: 2011
    ....
  27. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: A small molecule organ protective agent has significant clinical potential in renal transplantation. ..
  28. Combined neuroprotection and metabolic correction to treat leukodystrophies
    ERNESTO ROQUE BONGARZONE; Fiscal Year: 2013
    ....
  29. ROCK inhibitor suppression of GVHD with retention of GVL response
    Sujatha Iyengar; Fiscal Year: 2012
    ..Using ROCK inhibitors for GVHD is novel, and success would accelerate our long term goal of using ROCK inhibitors with BMT, to treat leukemias and other tumors. ..
  30. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2013
    ..It is hoped that the results of this study will allow safer application of this curative therapy to a greater number of patients and aid in improving tolerogenic therapy for autoimmunity and solid organ transplantation as well. ..
  31. Detection of Prostate Cancer Genomic Signatures in Blood
    Amin I Kassis; Fiscal Year: 2010
    ..In this Challenge grant application, we describe methods for the identification of tumor-specific signatures within the WBCs of men known to have prostate cancer. ..
  32. Human hepatocytes for drug toxicity screening from Cardiac Death Donor livers
    Mark G Clemens; Fiscal Year: 2012
    ..should allow us to quickly translate this innovative technology into a commercially viable product. ..
  33. Development of a Porcine Model of Ataxia-Telangiectasia
    Christopher Rogers; Fiscal Year: 2013
    ....
  34. Novel Catalases and their Products
    Alan R Brash; Fiscal Year: 2013
    ..By uncovering the details of how different enzymes deal with oxidants and how they relate or differ from each other this project will improve our understanding of oxidative stress, which will ultimately help control it. ..
  35. Genome instability in leukemia stem cell
    Tomasz Skorski; Fiscal Year: 2010
    ..These studies will break ground toward new directions in studying LSCs in CML and other leukemias, and in testing of novel therapeutic strategies. ..
  36. Epigenetic programming of brain development by choline nutrition
    Jan Krzysztof Blusztajn; Fiscal Year: 2011
    ....
  37. NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION
    MARIA INES MORANO; Fiscal Year: 2013
    ....
  38. Adipose Organ Transplant for Treatment of Maple Syrup Urine Disease
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2012
    ..The results of these studies will provide further evidence of the feasibility of this approach and guide us toward best practices and approaches to achieve a new therapy for MSUD. ..
  39. Mechanisms of oxidant-induced chronic bronchitis
    ROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012
    ....
  40. Role of H-Ras in Retinal Cell Death in Diabetes
    Renu A Kowluru; Fiscal Year: 2013
    ..This will offer patients additional therapeutic means to prevent/retard the sight-threatening complication of diabetes. ..
  41. Response of Rhesus Sperm to Freezing: Recovery from Osmotic and Oxidative Stress
    Stuart A Meyers; Fiscal Year: 2010
    ....
  42. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel S Greenberger; Fiscal Year: 2010
    ..These studies should elucidate the molecular mechanism of induction of damage to engrafting marrow origin, epithelial stem cells by the irradiated esophageal microenvironment and identify new targets for therapeutic intervention. ..
  43. Structure and Function of Enzymes in Fatty Acid Oxidation
    JUNG JA P KIM; Fiscal Year: 2013
    ....
  44. Plasma iNOS IVD Prognosticates Sepsis Prior to Organ Damage and Dysfunction
    Robert J Webber; Fiscal Year: 2010
    ....
  45. The Role of Beta-Arrestins 1 and 2 in Rheumatoid Arthritis
    Hongkuan Fan; Fiscal Year: 2010
    ..abstract_text> ..
  46. Immune activation by cetuximab in head and neck cancer patients
    Robert L Ferris; Fiscal Year: 2013
    ..abstract_text> ..
  47. Financial Risks and Ethnic/Racial Disparities in Live Kidney Donation
    TANJALA PURNELL; Fiscal Year: 2011
    ....
  48. The role of the Wnt/planar cell polarity pathway in pulmonary angiogenesis
    Vinicio A de Jesus Perez; Fiscal Year: 2013
    ....
  49. Tissue compartmentalization of human lymphocytes
    Donna L Farber; Fiscal Year: 2013
    ..The results obtained will lead to new strategies for tissue targeting of T cell responses in vaccines and immunotherapies. ..
  50. GB Virus C and Non-Hodgkins Lymphoma Risk and Prognosis
    Jack T Stapleton; Fiscal Year: 2013
    ..Regardless of the results obtained, this study has the potential to have a great impact on public health regarding transfusion medicine, and potentially in the clinical management of NHL patients. ..
  51. Pregnancy Folate Status &Early Childhood Respiratory &Atopic Disease Outcomes
    KECIA NICOLE CARROLL; Fiscal Year: 2013
    ..This study has potential to inform prenatal recommendations and identify modifiable risk factors for asthma and atopy. ..
  52. Abdominal Adipose Tissue Inflammation
    Peter S Tobias; Fiscal Year: 2013
    ..Collectively, these studies will provide key insight into an extreme atherosclerosis pathology linked to systemic inflammation resulting from chronic exposure to tissue injury, infectious agents and pathogens. ..
  53. Molecular mechanism of diet induced carcinogenesis
    Samson T Jacob; Fiscal Year: 2013
    ..This proposal also fits well with the recent program announcement of multiple institutes on diet, epigenetic events and cancer prevention. ..
  54. Development of Vaccine Strategies to prevent EBV+ Lymphoma in Patients with HIV
    ROBERT ALAN BAIOCCHI; Fiscal Year: 2010
    ..The project has great potential to make an impact on public health, job creation and economic growth. ..
  55. Histone proline isomerization and gene regulation
    Nobuaki Kikyo; Fiscal Year: 2010
    ..In addition, the results will facilitate the progress of nuclear reprogramming and regenerative medicine, especially creation of patients-derived rejection-free tissues for the purpose of transplantation. ..
  56. ANALYSIS OF A NOVEL SUBSET OF HUMAN CD8+ MEMORY CELLS WITH STEM CELL QUALITIES
    Stanley R Riddell; Fiscal Year: 2010
    ..The potential impact of this work relates to improving our understanding of the mechanisms responsible for the durability of human CD8+ T memory in normal individuals and those undergoing chemotherapy or vaccination. ..
  57. Induced Pluripotent Stem Cells from Swine: application to genetic modification
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..As the pig is an important reservoir for Salmonella, the LDLR-/- model will have a dual purpose for both agricultural and biomedical applications. ..
  58. Antenatal Dietary Supplementation is a Risk Factor for Infant Atopy Through Epige
    DAVID ALBERT SCHWARTZ; Fiscal Year: 2010
    ..Our research team proposes to determine if such concerns about methyl donor supplementation are justified and pose a real threat in expectant mothers already at risk for transmitting an atopic genetic predisposition to their infants. ..
  59. P53 and KRAS Targeted Pigs: A Platform for Models of Human Cancer
    Christopher Rogers; Fiscal Year: 2012
    ..These models will provide academic and industry researchers with an opportunity to better understand cancer and its pathogenesis and to develop and test new diagnostic, therapeutic, and preventative strategies. ..
  60. Folate and PSMA Interact to Regulate DNA Methylation and Prostate Carcinogenesis
    DENISE SUSAN O'KEEFE; Fiscal Year: 2013
    ....
  61. Targeting of alpha7 nAChR for therapeutic effects
    Roger L Papke; Fiscal Year: 2013
    ..We will use our new discoveries about how these drugs work to help make alpha7-stimulating drugs optimally designed to treat specific diseases. ..
  62. HIV, HCV and Liver Disease Among Injection Drug Users in Chennai, India
    Shruti H Mehta; Fiscal Year: 2013
    ..to inform interventions to reduce the morbidity and mortality associated with drug use, HIV and hepatitis C. ..
  63. Phase 2 Study of rAAV1-CB-hAAT for Treatment of Alpha-1 Antitrypsin Deficiency
    Jeffrey D Chulay; Fiscal Year: 2013
    ..Results from this Phase 2 trial will be used to develop a Phase 3 study designed to satisfy the requirements for licensure of a gene therapy treatment for this orphan disease. ..
  64. PAIRING OF HOMOLOGOUS SEQUENCES IN DROSOPHILA
    KENT GOLIC; Fiscal Year: 2002
    ....
  65. Geographically robust rapid assay for T. cruzi infection
    SYAMAL X RAYCHAUDHURI; Fiscal Year: 2010
    ..In conclusion rapid diagnostic and confirmatory tests will be highly valuable in Latin America countries and in the USA in a point-of-care situation as well as in blood banks. ..
  66. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn J Pelletier; Fiscal Year: 2010
    ....
  67. Development of ex vivo Expanded Megakaryocyte Progenitors for Platelet Recovery F
    Holger Karsunky; Fiscal Year: 2009
    ..Completion of these proposed goals should enable Cellerant to move this potential product close to initiate IND enabling pre-clinical toxicology studies and subsequently Phase I clinical trials. ..
  68. NF-kB Inhibition of Lung Ischemia Repurfusion Injury
    Patrick Flood; Fiscal Year: 2009
    ....
  69. Novel Molecular and Cellular Therapies in Fanconi Anemia
    David Williams; Fiscal Year: 2009
    ..This grant proposal seeks funding to conduct these clinical trials and further develop retrovirus-mediated complementation analysis in a CAP/CLIA environment for use in clinical management of FA patients. ..
  70. BIOLOGIC AND IMMUNOLOGIC ASPECTS OF TRANSFUSION MEDICINE
    Sherrill Slichter; Fiscal Year: 2009
    ..End of Abstract) ..
  71. Achieving Consensus on High Risk Donor to Improve Access to Organ Transplants
    Michael G Ison; Fiscal Year: 2011
    ....
  72. OPTIMIZING ALLOGENEIC TRANSPLANTATION USING CXCR4 BLOCKADE
    John F DiPersio; Fiscal Year: 2010
    ..These studies will provide the foundation for generating improved stem cell allografts in less time and with improved safety to the donors and outcomes for the recipients compared to G-CSF. ..
  73. CTRIP Ex-vivo perfusion and ventilation of lungs to assess transplant suitability
    Thomas M Egan; Fiscal Year: 2010
    ..This would provide much larger numbers of human lungs for transplant that may function better and last longer than lungs currently being transplanted from conventional brain-dead organ donors. ..
  74. The effect of TLR4 inhibition on lung transplant ischemia-reperfusion injury
    PERRY ARTHUR GENOVA; Fiscal Year: 2010
    ..This work may expand the supply of healthy lungs for transplant and could stop IRI in heart attack, stroke or heart bypass. ..
  75. CENTROSOME DEFECTS AS CAUSES OF MALE INFERTILITY
    Gerald Schatten; Fiscal Year: 1999
    ....
  76. IMMUNOLOGY OF BACTERIAL PNEUMONIA IN HTLV-II INFECTION
    GARY JARVIS; Fiscal Year: 2002
    ..The effect of HTLV-II infection of human T cells on cytokine-dependent activation of macrophages and PMN will be studied using functional assays of pneumococcal phagocytic killing. ..
  77. MYOBLAST GROWTH AND DIFFERENTIATION DURING MUSCLE AGING
    Charlotte Peterson; Fiscal Year: 2000
    ..The feasibility of using IGFs as therapeutic agents to maintain muscle mass in the elderly can then be evaluated. ..
  78. SUPPLY, EVALUATION AND SELECTION OF LIVING RENAL DONORS
    Akinlolu Ojo; Fiscal Year: 2001
    ..The prospective donor database will demonstrate the feasibility of a multi- center living renal donor registry which is essential to future research in living renal donation. ..
  79. NUCLEOTIDE DONORS AFFECTING GLYCOSYLATION PATHWAYS
    Ajit Varki; Fiscal Year: 2003
    ....
  80. Ethical Issues in Living Donor Transplantation
    Lainie Ross; Fiscal Year: 2009
    ..Part VI provides a methodological consideration of the numerous policy recommendations and revisions that are offered throughout the book to promote the ethical participation of living persons as organ sources. ..