hiv long term survivors

Summary

Summary: Persons who have experienced prolonged survival of HIV infection. This includes the full spectrum of untreated, HIV-infected long-term asymptomatics to those with AIDS who have survived due to successful treatment.

Top Publications

  1. ncbi CD4 T cell surface CCR5 density as a host factor in HIV-1 disease progression
    J Reynes
    Service des Maladies Infectieuses et Tropicales, , Montpellier, France
    AIDS 15:1627-34. 2001
  2. pmc Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors
    Minoru Tobiume
    Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Virol 76:5959-65. 2002
  3. pmc Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by a two-amino-acid insertion in HIV-1 Vif from a nonprogressing mother and child
    Louis Alexander
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520, USA
    J Virol 76:10533-9. 2002
  4. ncbi The role of Vpr in HIV-1 disease progression is independent of its G2 arrest induction function
    Maoyi Lai
    Department of Molecular Pharmacology and Experimental Therapeutics, and Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cell Cycle 5:2275-80. 2006
  5. pmc Changes in paracrine interleukin-2 requirement, CCR7 expression, frequency, and cytokine secretion of human immunodeficiency virus-specific CD4+ T cells are a consequence of antigen load
    John C Tilton
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC 1876, Bethesda, MD 20892 1876, USA
    J Virol 81:2713-25. 2007
  6. ncbi Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history study
    Jason F Okulicz
    Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Infect Dis 200:1714-23. 2009
  7. ncbi Mechanisms involved in non-progressive HIV disease
    Meriet Mikhail
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney NSW 2145, Australia
    AIDS Rev 5:230-44. 2003
  8. ncbi A systematic comparison of methods to measure HIV-1 specific CD8 T cells
    Y Sun
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Centre Hospitalier Pitié Salpétrière, 83 boulevard d l hôpital, Batiment CERVI, 75013 Paris, France
    J Immunol Methods 272:23-34. 2003
  9. ncbi An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC)
    M R Birch
    HIV Epidemiology Research Unit HERU, Australian Red Cross Blood Service NSW ARCBS NSW, Level 3 131 Clarence Street, Sydney, NSW 2000, Australia
    J Clin Virol 22:263-70. 2001
  10. pmc Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:66. 2007

Detail Information

Publications155 found, 100 shown here

  1. ncbi CD4 T cell surface CCR5 density as a host factor in HIV-1 disease progression
    J Reynes
    Service des Maladies Infectieuses et Tropicales, , Montpellier, France
    AIDS 15:1627-34. 2001
    ..Consequently, CCR5 density quantitation could be a new valuable prognostic tool in HIV-1 infection. Moreover, these data emphasize the therapeutic potential of treatments that reduce functional CCR5 density...
  2. pmc Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors
    Minoru Tobiume
    Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Virol 76:5959-65. 2002
    ..It awaits further study to conclude that these characteristics of nef alleles are the cause or the consequence of the long-term nonprogression after HIV-1 infection...
  3. pmc Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by a two-amino-acid insertion in HIV-1 Vif from a nonprogressing mother and child
    Louis Alexander
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520, USA
    J Virol 76:10533-9. 2002
    ..Further studies of these sequences might provide information regarding contributions of Vif structure and/or function to HIV-1 virulence...
  4. ncbi The role of Vpr in HIV-1 disease progression is independent of its G2 arrest induction function
    Maoyi Lai
    Department of Molecular Pharmacology and Experimental Therapeutics, and Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cell Cycle 5:2275-80. 2006
    ..We propose that the G(2) arrest function of Vpr is separated from the LTNP phenotype, and the role of Vpr in HIV disease progression may involve other functions of Vpr...
  5. pmc Changes in paracrine interleukin-2 requirement, CCR7 expression, frequency, and cytokine secretion of human immunodeficiency virus-specific CD4+ T cells are a consequence of antigen load
    John C Tilton
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC 1876, Bethesda, MD 20892 1876, USA
    J Virol 81:2713-25. 2007
    ..In addition, defects in function and phenotype of HIV-specific CD4+ T cells are not readily discernible in the context of antiretroviral therapy but rather are similar to responses to other viruses...
  6. ncbi Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history study
    Jason F Okulicz
    Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Infect Dis 200:1714-23. 2009
    ..042). Definitions of controllers and LTNPs describe distinct populations whose differing clinical outcomes improve with the stringency of criteria, underscoring the need for comparability between study populations...
  7. ncbi Mechanisms involved in non-progressive HIV disease
    Meriet Mikhail
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney NSW 2145, Australia
    AIDS Rev 5:230-44. 2003
    ....
  8. ncbi A systematic comparison of methods to measure HIV-1 specific CD8 T cells
    Y Sun
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Centre Hospitalier Pitié Salpétrière, 83 boulevard d l hôpital, Batiment CERVI, 75013 Paris, France
    J Immunol Methods 272:23-34. 2003
    ..These results have important implications for the choice of immunological methods to evaluate CD8 T cells responses to vaccines...
  9. ncbi An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC)
    M R Birch
    HIV Epidemiology Research Unit HERU, Australian Red Cross Blood Service NSW ARCBS NSW, Level 3 131 Clarence Street, Sydney, NSW 2000, Australia
    J Clin Virol 22:263-70. 2001
    ..In contrast, in the SA cohort, comparison study group for the SBBC, five of 24 remain therapy naïve after 15 years infection with HIV-1 and all have detectable VL...
  10. pmc Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:66. 2007
    ....
  11. pmc Characterization of three nef-defective human immunodeficiency virus type 1 strains associated with long-term nonprogression. Australian Long-Term Nonprogressor Study Group
    D I Rhodes
    AIDS Molecular Biology Unit, National Centre in HIV Virology Research, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria 3078, Australia
    J Virol 74:10581-8. 2000
    ..All three strains of virus had envelope sequences characteristic of macrophagetropic viruses. These findings further indicate the reduced pathogenic potential of nef-defective viruses...
  12. ncbi A combination of defective DNA and protective host factors are found in a set of HIV-1 ancestral LTNPs
    Virginia Sandonis
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera de Pozuelo Km 2, Majadahonda, 28220 Madrid, Spain
    Virology 391:73-82. 2009
    ..These HIV controllers presented a combination of deleted viral genomes and host protective factors...
  13. ncbi 'In an important way, I did die': uncertainty and revival in persons living with HIV or AIDS
    D E Brashers
    Department of Speech Communication, University of Illinois, Urbana 61801 3631, USA
    AIDS Care 11:201-19. 1999
    ..Implications for prevention, practice, research and theory are presented and suggestions for education and assistance are offered...
  14. pmc The differential ability of HLA B*5701+ long-term nonprogressors and progressors to restrict human immunodeficiency virus replication is not caused by loss of recognition of autologous viral gag sequences
    Stephen A Migueles
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:6889-98. 2003
    ..Qualitative features of the virus-specific CD8(+) T-cell response not measured by current assays remain the most likely determinants of the differential abilities of HLA B(*)5701(+) LTNPs and progressors to restrict virus replication...
  15. pmc Continuous viral escape and selection by autologous neutralizing antibodies in drug-naive human immunodeficiency virus controllers
    Madhumita Mahalanabis
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    J Virol 83:662-72. 2009
    ..Strong ANAb responses directed against autologous Env variants are present in long-term chronically infected individuals, suggesting a role for these responses in contributing to the durable control of HIV replication...
  16. ncbi Antibodies to conserved epitopes of the HIV-1 envelope in sera from long-term non-progressors: prevalence and association with neutralizing activity
    Martine Braibant
    Laboratoire de Virologie, Universite Francois Rabelais, INSERM ERI 19, 37044 Tours Cedex, France
    AIDS 20:1923-30. 2006
    ....
  17. pmc Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor
    Justin R Bailey
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 82:7395-410. 2008
    ..The results strongly suggest that through direct and indirect mechanisms, CD8(+) T cells in some ES control HIV-1 isolates are capable of causing profound immunosuppression...
  18. pmc Viral phenotypes and antibody responses in long-term survivors infected with attenuated human immunodeficiency virus type 1 containing deletions in the nef and long terminal repeat regions
    Erin E Verity
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    J Virol 81:9268-78. 2007
    ..Despite the presence of strong neutralizing antibodies in a number of SBBC members, disease progression was not prevented, and each cohort member studied displayed a unique outcome of infection with nef-attenuated HIV-1...
  19. ncbi Presence of HIV-1 Gag-specific IFN-gamma+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection
    Mark J Boaz
    Department of Immunology, Guy s, King s, and St Thomas School of Medicine and Dentistry, King s College London, United Kingdom
    J Immunol 169:6376-85. 2002
    ..Accumulation of specific CD28(-)IL-2(+) helpers and loss of IFN-gamma(+)IL-2(+) CD4 T cells may compromise specific CD8 responses and, in turn, immunity to HIV...
  20. ncbi HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
    Stephen A Migueles
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Nat Immunol 3:1061-8. 2002
    ..In addition, the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control...
  21. pmc Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses
    A D Kelleher
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Exp Med 193:375-86. 2001
    ..Outgrowth of CTL escape viruses required high viral loads and additional, possibly compensatory, mutations in the gag protein...
  22. pmc Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus
    Melissa J Churchill
    The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:43. 2007
    ..Therefore, to determine whether defects in other viral genes contribute to attenuation of these HIV-1 strains, we characterized dominant HIV-1 rev alleles that persisted in 4 SBBC subjects; C18, C64, C98 and D36...
  23. ncbi HLA and other host factors in transfusion-acquired HIV-1 infection
    A F Geczy
    Australian Red Cross Blood Service NSW, Sydney, Australia
    Hum Immunol 61:172-6. 2000
    ....
  24. pmc Evidence for a cytopathogenicity determinant in HIV-1 Vpr
    Mohan Somasundaran
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 99:9503-8. 2002
    ..This study suggests the presence of a determinant of in vivo cytopathogenicity within HIV-1 Vpr and further indicates that viral replication can be uncoupled from cytopathicity in vitro and in vivo...
  25. ncbi Lack of temporal structure in the short term HIV-1 evolution within asymptomatic naïve patients
    Gonzalo Bello
    Centro Nacional de Microbiología CNM, Instituto de Salud Carlos III, Majadahonda, Madrid 28220, Spain
    Virology 362:294-303. 2007
    ..These results support the existence of distinct patterns of env evolution in untreated HIV-1-infected patients...
  26. ncbi High frequency of nonprogression 20 years after transfusion-transmitted human immunodeficiency virus type-1 infection
    Wayne B Dyer
    Transfusion 44:1397-8. 2004
  27. ncbi Initiation of antiretroviral therapy during recent HIV-1 infection results in lower residual viral reservoirs
    Antonio Pires
    Department of Immunology, Imperial College London, UK
    J Acquir Immune Defic Syndr 36:783-90. 2004
    ....
  28. ncbi A subset of human immunodeficiency virus type 1 long-term non-progressors is characterized by the unique presence of ancestral sequences in the viral population
    Gonzalo Bello
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
    J Gen Virol 86:355-64. 2005
    ....
  29. ncbi Correlates of antiviral immune restoration in acute and chronic HIV type 1 infection: sustained viral suppression and normalization of T cell subsets
    Wayne B Dyer
    Australian Red Cross Blood Service, Sydney, NSW 2000, Australia
    AIDS Res Hum Retroviruses 18:999-1010. 2002
    ..This study uniquely demonstrates that dual-PI regimens are superior in achieving these levels of virological control and immune restoration in both chronic and acute infection, compared with single-PI or non-PI regimens...
  30. pmc Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, Victoria, Australia
    Virol J 4:75. 2007
    ..To better understand mechanisms underlying the pathogenicity of nef-deleted HIV-1, we examined the phenotype and env sequence diversity of sequentially isolated viruses (n = 2) from 3 SBBC members...
  31. pmc A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection
    Nesrina Imami
    Department of Immunology, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom
    J Virol 76:9011-23. 2002
    ..These results suggest that a balanced type 1/type 2 profile correlates with successful long-term control of HIV-1...
  32. ncbi Molecular characterization of the HIV type 1 vpr gene in infected Chinese former blood/plasma donors at different stages of diseases
    Chengli Shen
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 24:661-6. 2008
    ..These results show that vpr may not play an important role in HIV-1 pathogenesis in different stages of Chinese patients and may have important implications in developing vpr-related treatments suitable for HIV-1-infected PBDs...
  33. ncbi Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    Florencia Pereyra
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    J Infect Dis 197:563-71. 2008
    ..The mechanisms behind this outcome remain largely unknown, and a better understanding of them will likely influence future vaccine strategies...
  34. ncbi Preservation of T cell proliferation restricted by protective HLA alleles is critical for immune control of HIV-1 infection
    Helen Horton
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 177:7406-15. 2006
    ..Our findings suggest that the capacity to maintain CD8+ T cell proliferation, regardless of MHC-restriction, may serve as an important correlate of disease protection in the event of infection following vaccination...
  35. ncbi Characterization of GBV-C infection in HIV-1 infected patients
    F Canducci
    San Raffaele Microbiology and Virology, Diagnostics and Research, Milan, Italy
    J Biol Regul Homeost Agents 17:191-4. 2003
    ....
  36. ncbi Plasma viral load threshold for sustaining intrahost HIV type 1 evolution
    Gonzalo Bello
    Laboratorio de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    AIDS Res Hum Retroviruses 23:1242-50. 2007
    ..These results suggest that the detection limit of ultrasensitive viremia assays could represent an important threshold below which intrahost HIV-1 evolution does not occur...
  37. ncbi Neurophysiological abnormalities in HIV-infected long term survivors
    Christoph Kellinghaus
    Department of Neurology, University of Munster, Albert Schweitzer Str 33, D 48129 Munster, Germany
    Eur J Med Res 11:245-9. 2006
    ..We investigated the prevalence and severity of neurophysiological abnormalities in LTS...
  38. ncbi The prospects for vaccines against HIV-1: more than a field of long-term nonprogression?
    Neil Sheppard
    The Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford, OX1 3RE, UK
    Expert Rev Mol Med 7:1-21. 2005
    ..Now it is time to examine the prospects for HIV-1 vaccines and ascertain whether real progress is being made...
  39. ncbi Detection of human herpesvirus 7 DNA in peripheral blood reflects mainly CD4+ cell count in patients infected with HIV
    David Boutolleau
    Laboratoire de Virologie, UPRES EA 2387, Groupe Hospitalier Pitie Salpetriere, Paris, France
    J Med Virol 76:223-8. 2005
    ..Rather, HHV-7 detection rate and cell load reflect CD4(+) T-lymphocyte count, with higher values in healthy donors and long-term non-progressors than in progressors...
  40. ncbi HIV-2-infected individuals with undetectable plasma viremia carry replication-competent virus in peripheral blood lymphocytes
    Hetty Blaak
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Acquir Immune Defic Syndr 36:777-82. 2004
    ..88, P < 0.0001). The low infectious load in aviremic HIV-2-infected persons is reminiscent of what has been observed for HIV-1 infection controlled by highly active antiretroviral therapy...
  41. pmc Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Ralpha on central and effector memory CD4+ and CD8+ T cell subsets
    F Mercier
    Immunodeficiency Service, Montreal Chest Institute, Montreal, Quebec, Canada
    Clin Exp Immunol 152:72-80. 2008
    ..Collectively, these results provide further insight on the role of unsuppressed viral load in disrupting the IL-7/IL-7Ralpha system and contributing to HIV-1 disease progression...
  42. ncbi Can we really identify HIV-1 long-term nonprogressors?
    Sandro Vento
    J Acquir Immune Defic Syndr 37:1218-9. 2004
  43. ncbi Full-length HIV type 1 genome analysis showing evidence for HIV type 1 transmission from a nonprogressor to two recipients who progressed to AIDS
    Meriet Mikhail
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW 2145, Sydney, Australia
    AIDS Res Hum Retroviruses 21:575-9. 2005
    ..Overall, these studies highlight the utility of full genome sequencing in establishing epidemiologic linkage in a chronically infected HIV cohort after 10 years of initial infection...
  44. ncbi Slow progression of HIV-1 infection in a cohort of antiretroviral naïve hotel workers in Dar es Salaam, Tanzania as defined by their CD4 cell slopes
    Muhammad Bakari
    Department of Internal Medicine, Muhimbili University College of Health Sciences MUCHS, P O Box 65001, Dar es Salaam, Tanzania
    Scand J Infect Dis 40:407-13. 2008
    ..An analysis of the selection bias introduced during slope determination is presented. With no selection, 24 (23.3%) would have documented slow CD4 progression among those enrolled for 5 or more y regardless of CD4 determinations...
  45. pmc Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors
    Milan Reinis
    Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
    AIDS Res Hum Retroviruses 23:309-15. 2007
    ..This study highlights the potential of full genome analysis in the investigation of pathogenesis and immune selection during HIV-1 evolution...
  46. ncbi Functional T cell subsets contribute differentially to HIV peptide-specific responses within infected individuals: correlation of these functional T cell subsets with markers of disease progression
    Yoav Peretz
    Research Institute of the McGill University Health Center, Montreal General Hospital, Montreal, Quebec, Canada
    Clin Immunol 124:57-68. 2007
    ....
  47. pmc HIV VprR77Q mutation does not influence clinical response of individuals initiating highly active antiretroviral therapy
    Celia Chui
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    AIDS Res Hum Retroviruses 22:615-8. 2006
    ..1). The high prevalence and the lack of association with pretherapy clinical parameters in this cohort argue against an association of R77Q with LTNP status. These results do not support an association between R77Q and HAART response...
  48. ncbi Vpr and HIV-1 disease progression: R77Q mutation is associated with long-term control of HIV-1 infection in different groups of patients
    Daniela Mologni
    Institute of Infectious and Tropical Diseases, University of Milan, L Sacco Hospital, Milan, Italy
    AIDS 20:567-74. 2006
    ..Recent studies have focused on the role of a mutation at position 77 that might be associated with the condition of long-term non-progression, but data are still controversial...
  49. doi Laboratory characteristics of HIV-1 clade C-infected long-term non-progressors at a tertiary human immunodeficiency virus care centre in South India
    Uma Shanmugasundaram
    J Med Microbiol 57:913-5. 2008
  50. ncbi HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors
    Véronique Avettand-Fenoel
    AP HP, Laboratoire de Virologie, CHU Necker Enfants Malades, Universite Paris Descartes, Paris, France
    AIDS 22:1880-2. 2008
    ..They were positively correlated (r = 0.841, P<0.0001). Long-term nonprogressors and patients in 'remission' after antiretroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels...
  51. ncbi Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection
    Melody G Duvall
    Medical Research Council MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 176:6973-81. 2006
    ..This study demonstrates that HIV-2-infected donors have a well-preserved and functionally heterogeneous HIV-specific memory CD4+ T cell response that is associated with delayed disease progression in the majority of infected people...
  52. ncbi Differences in disease progression in a cohort of long-term non-progressors after more than 16 years of HIV-1 infection
    Berta Rodes
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS 18:1109-16. 2004
    ..It is unclear whether resistance to immunologic damage in long-term non-progressors (LTNP) will last indefinitely or whether it merely represents the extreme of a Gaussian distribution, and therefore progression will occur eventually...
  53. ncbi HIV-1-specific CD8 T cell responses in a pediatric slow progressor infected as a premature neonate
    Rana Chakraborty
    University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, UK
    AIDS 16:2085-7. 2002
    ..HIV-1 infection as early as 25 weeks' gestation may thus results in the development of immune responses that control viral replication and lead to prolonged survival...
  54. ncbi Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57
    Geraldine M A Gillespie
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    AIDS 16:961-72. 2002
    ....
  55. ncbi An observational study on patients treated or not for acute HIV infection
    C Mussini
    Clinic of Infectious Diseases, Policlinico and University of Modena and Reggio Emilia, Italy
    J Biol Regul Homeost Agents 16:79-82. 2002
    ..Open questions are how can we identify patients who will be slow progressors or long-term non progressors, and, as a consequence, do not require treatment...
  56. ncbi HIV pathogenesis: knowledge gained after two decades of research
    J A Levy
    Laboratory for Tumor and AIDS Research, University of California, San Francisco, 513 Parnassus Avenue, Suite S1280, San Francisco, CA 94143 1270, USA
    Adv Dent Res 19:10-6. 2006
    ..The past 20 years have yielded important information on HIV/AIDS that should lead to effective anti-HIV therapies and a vaccine...
  57. ncbi Herpesvirus saimiri-immortalized human lymphocytes: novel hosts for analyzing HIV type 1 in vitro neutralization
    Cherelyn Vella
    School of Biological and Applied Sciences, University of North London, London N7 8DB, UK
    AIDS Res Hum Retroviruses 18:933-46. 2002
    ..Thus CN-2 cells are suitable hosts for assaying neutralization and could be useful in standardizing neutralization assays performed in different laboratories...
  58. ncbi Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor
    Linqi Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Science 298:995-1000. 2002
    ..Taken together, our results indicate that alpha-defensin 1, 2, and 3 collectively account for much of the anti-HIV-1 activity of CAF that is not attributable to beta-chemokines...
  59. pmc Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals
    Tuofu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle 98195, USA
    J Virol 77:6108-16. 2003
    ..Understanding the mechanisms that confer diminished replicative capacity of HIV-1 in these hosts is paramount to developing strategies for protection against and control of HIV-1 infection...
  60. ncbi HIV-1 and AIDS: what are protective immune responses?
    Tara Beattie
    Clinical Sciences Division, University of Toronto, Ontario, Canada
    J HIV Ther 7:35-9. 2002
    ..Achieving this goal will at least require the induction of HIV-1-specific cellular immune responses at the site of initial viral contact (generally the genital tract), perhaps in combination with HIV-1-specific neutralising antibody...
  61. pmc CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression
    Nicoletta Casartelli
    Division of Immunology and Infectious Disease, Children s Hospital Bambino Gesu, Rome, Italy
    J Virol 77:11536-45. 2003
    ..Our data indicate that Nef-mediated downregulation of cell surface CD4 and MHC-I significantly contributes to the expression of the pathogenic potential of HIV-1...
  62. ncbi Proliferative responses to human immunodeficiency virus type 1 (HIV-1) antigens in HIV-1-infected patients with immune reconstitution
    J N Blankson
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Infect Dis 183:657-61. 2001
    ..These results suggest that, in some patients with advanced HIV-1 infection, treatment with HAART can lead not only to significant increases in CD4 cell counts but also to the restoration of HIV-1-specific responses...
  63. ncbi Increased in vitro replication of CC chemokine receptor 5-restricted human immunodeficiency virus type 1 primary isolates in Th2 lymphocytes may correlate with AIDS progression
    Harold Ofori
    University of Medical Sciences, Department of Biochemistry and Molecular Biology, 60 781 Poznan, Poland
    Scand J Infect Dis 36:46-51. 2004
    ..Our data indicates that Th0/Th2 cell orientation in HIV-infected individuals and a higher replication of R5 HIV-1 primary isolates in AIDS progressors than long term-survivors can be associated with progression to AIDS...
  64. ncbi High frequency of grossly deleted nef genes in HIV-1 infected long-term slow progressors treated with Korean red ginseng
    Young K Cho
    Department of Microbiology, University of Ulsan College of Medicine, Seoul, South Korea
    Curr HIV Res 4:447-57. 2006
    ..8% in control patients (P < 0.001). In addition, it significantly increased as the duration of KRG intake prolongs (P < 0.01). These data suggest that the occurrence of gDeltanef might be associated with long-term intake of KRG...
  65. ncbi Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children
    D B Tzitzivacos
    HIV Pathogenesis Research Laboratory, Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, Parktown, Johannesburg 2193, South Africa
    AIDS Res Hum Retroviruses 25:1141-8. 2009
    ..For example, LT46 Nef is unable to bind AP-1 and AP-2 and therefore is inactive on CD4 endocytosis. The biological relevance of these findings requires further investigation...
  66. pmc A comparison of viral loads between HIV-1-infected elite suppressors and individuals who receive suppressive highly active antiretroviral therapy
    Jason B Dinoso
    1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 47:102-4. 2008
    ....
  67. pmc A single measurement of CD38CD8 cells in HIV+, long-term surviving injecting drug users distinguishes those who will progress to AIDS from those who will remain stable
    K S Froebel
    Centre for HIV Research, ICAPB, University of Edinburgh, UK
    Clin Exp Immunol 122:72-8. 2000
    ..The results demonstrate the considerable added value of the CD8+CD38+ cell percentage over the CD4 count alone, in predicting HIV clinical progression...
  68. ncbi Decreased function of Fas in patients displaying delayed progression of HIV-induced immune deficiency
    F Bottarel
    Department of Medical Science, A Avogadro University of Eastern Piedmont, 28100 Novara, Italy
    Hematol J 2:220-7. 2001
    ..This study evaluates the possibility that Fas function defects delay progression of HIV-induced immune deficiency...
  69. pmc Challenges associated with increased survival among parents living with HIV
    M Lee
    Department of Psychiatry, UCLA, 10920 Wilshire Blvd, Suite 350, Los Angeles, CA 90024, USA
    Am J Public Health 91:1303-9. 2001
    ..This study examined sociodemographic and psychosocial factors that predict survival among parents living with HIV...
  70. ncbi Mannose-binding lectin in susceptibility and progression of HIV-1 infection in children
    Agnieszka Dzwonek
    Infectious Diseases Et Microbiology Unit, Institute of Child Health, University College London, UK
    Antivir Ther 11:499-505. 2006
    ..We have investigated the effect of MBL-2 polymorphisms on susceptibility and progression of HIV-1 infection in children...
  71. ncbi Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France
    Nat Protoc 5:1033-41. 2010
    ..We also depict the conditions of a rapid assay on the basis of flow cytometry analysis of intracellular HIV-Gag products. These procedures take 14-17 d when the p24 ELISA assay is used, or 6 d with the intracellular Gag assay...
  72. ncbi The innate cellular responses to HIV-1 invasion: emerging molecules of ancient defense mechanisms
    Malgorzata Simm
    Molecular Virology Division, St Luke s Roosevelt Hospital Center, Columbia University, 432 West 58th St, Rm 709, New York, NY 10019, USA
    Arch Immunol Ther Exp (Warsz) 55:131-8. 2007
    ..Research efforts to identify this inhibitor of HIV--a "magic bullet" released by our immune cells--have revealed the identity of several novel molecules and added to the knowledge of innate cellular responses to viral invasion...
  73. ncbi [Hepatitis B vaccination effectiveness based on anti-HBs antibodies presence in children vertically infected with HIV]
    Agnieszka Ołdakowska
    Klinika Chorob Zakaznych Wieku Dzieciecego, Warszawski Uniwersytet Medyczny, Wojewódzki Szpital Zakaźny w Warszawie
    Przegl Epidemiol 64:323-8. 2010
    ..To evaluate hepatitis B vaccination effectiveness...
  74. ncbi Nef alleles from children with non-progressive HIV-1 infection modulate MHC-II expression more efficiently than those from rapid progressors
    Michael Schindler
    Institute of Virology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    AIDS 21:1103-7. 2007
    ..It has been established that defective nef genes and differences in the Nef-mediated downmodulation of CD4 and MHC-I cell surface expression can be associated with different rates of HIV-1 disease progression...
  75. pmc Multiple risk behaviors among youth living with human immunodeficiency virus in five U.S. cities
    Mary R Tanney
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Adolesc Health 46:11-6. 2010
    ..To describe multiple risk behaviors (substance use, sexual risk, and medication adherence) in a multi-site sample of youth living with human immunodeficiency virus (HIV) in five U.S. cites...
  76. pmc Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables
    Nicole A Doria-Rose
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 84:1631-6. 2010
    ..Clustering analysis of sera by a novel method identified a statistically robust subgrouping of sera that demonstrated broad and potent neutralization activity...
  77. ncbi Humoral immunity in HIV-1 exposure: cause or effect of HIV resistance?
    Lucia Lopalco
    Clinics for Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Curr HIV Res 2:127-39. 2004
    ....
  78. ncbi Effector HIV-specific cytotoxic T-lymphocyte activity in long-term nonprogressors: associations with viral replication and progression
    Elizabeth Keoshkerian
    Department of Immunology and Infectious Diseases, Sydney Children s Hospital, Randwick, Australia
    J Med Virol 71:483-91. 2003
    ..These findings demonstrate the importance of HIV replication in generating an effector CTL response and show that effector CTL activity may be an early predictor of progression in people with long-term asymptomatic HIV infection...
  79. pmc Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection
    Wayne B Dyer
    Australian Red Cross Blood Service, 153 Clarence Street, Sydney, NSW 2000, Australia
    Retrovirology 5:112. 2008
    ..We examined the mechanisms that differentiated delayed progressors from LTNP in this cohort...
  80. ncbi [HIV-1 nef specific cytotoxic T lymphocyte responses in long-term nonprogressors and AIDS patients]
    Hong Wei Zhang
    Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 84:1973-6. 2004
    ..To investigate the HIV-1 nef specific CD8(+) T cell responses in long-term nonprogressor (LTNP) and AIDS patient in China...
  81. ncbi Dynamics of cytomegalovirus (CMV)-specific T cells in HIV-1-infected individuals progressing to AIDS with CMV end-organ disease
    Corine Bronke
    Department of Clinical Viro Immunology, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
    J Infect Dis 191:873-80. 2005
    ....
  82. ncbi Experiences of contemplating returning to work for people living with HIV/AIDS
    Stephanie Nixon
    Joint Centre for Bioethics, University of Toronto, Canada
    Qual Health Res 13:1272-90. 2003
    ..Findings have conceptual and methodological implications for literature in HIV/AIDS, return to work, and identity...
  83. ncbi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  84. ncbi 15th International AIDS Conference. News on treatment and social issues. Monotherapy, clean needles, and more
    Enid Vázquez
    Posit Aware 15:24-6. 2004
  85. pmc AIDS among older children and adolescents in Southern Africa: projecting the time course and magnitude of the epidemic
    Rashida A Ferrand
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    AIDS 23:2039-46. 2009
    ..An AIDS epidemic among older children and adolescents is clinically apparent in Southern Africa. We estimated the likely scale and time course of the epidemic in older survivors of vertical HIV infection...
  86. ncbi Constructions of masculinity among a group of South African men living with HIV/AIDS: reflections on resistance and change
    Ingrid Lynch
    Department of Psychology, University of Pretoria, South Africa
    Cult Health Sex 12:15-27. 2010
    ..A final discourse relates to a transformed masculinity, where men living with HIV reconstruct their masculinity, as conforming to normative constructions of male identity is perceived as restrictive and harmful...
  87. ncbi 'Doing' chronic illness? Complementary medicine use among people living with HIV/AIDS in Australia
    Rachel D Thorpe
    The Australian Research Centre in Sex, Health and Society, La Trobe University, 215 Franklin Street, Melbourne, Victoria 3000, Australia
    Sociol Health Illn 31:375-89. 2009
    ..The article is based on 18 qualitative interviews with people living with HIV/AIDS who were using complementary medicine...
  88. ncbi Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele
    Francesc Vidal
    Hospital Universitari de Tarragona Joan XXIII and Universitat Rovira i Virgili, Tarragona, Catalonia, Spain
    J Acquir Immune Defic Syndr 40:527-31. 2005
    ..This study aimed to determine whether functionally active CX3CR1 genetic variants are associated with long-term nonprogressive infection of >15 years in HIV-1-infected Spanish patients...
  89. pmc Better quality of life with neuropsychological improvement on HAART
    Thomas D Parsons
    AIDS Neurological Center, University of North Carolina, Chapel Hill, NC 27599 7025, USA
    Health Qual Life Outcomes 4:11. 2006
    ..Cognitive impairment can dramatically impact functional ability and day-to-day productivity. We assessed the relationship of quality of life (QOL) and neuropsychological functioning with successful HAART treatment...
  90. pmc Factors associated with improvement in disability-adjusted life years in patients with HIV/AIDS
    Clara Bermúdez-Tamayo
    Andalusian School of Public Health, Granada, Spain
    BMC Public Health 8:362. 2008
    ..The aim was to determine which factors are associated with improvements in the level of health of male and female patients with HIV/AIDS in Andalusia, in terms of disability-adjusted life years...
  91. pmc Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20092, USA
    Proc Natl Acad Sci U S A 103:7000-5. 2006
    ..TRAIL mRNA levels in LT correlated with plasma viral load. We show that HIV-1 induces IFN-alpha and the TRAIL/DR5 apoptotic pathway in LT, suggesting a role for these cytokines in HIV-1 immunopathogenesis...
  92. ncbi Coreceptor usage, diversity, and divergence in drug-naive and drug-exposed individuals from Malawi, infected with HIV-1 subtype C for more than 20 years
    Ishla Seager
    1 Molecular Evolution and Systematics Laboratory, Zoology, Ryan Institute, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland
    AIDS Res Hum Retroviruses 30:975-83. 2014
    ....
  93. ncbi In vitro replication capacity of HIV-2 variants from long-term aviremic individuals
    Hetty Blaak
    Department of Virology, Erasmus Medical Center Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Virology 353:144-54. 2006
    ..The relatively low replicative capacity of HIV-2 variants from aviremic individuals likely contributes to the low viral load and benign course of infection in these individuals...
  94. ncbi Labour participation of people living with HIV/AIDS in Spain
    Juan Oliva
    Departamento de Análisis Económico y Finanzas, Fundación de Estudios de Economía Aplicada, CIBER Epidemiología y Salud Pública, Universidad de Castilla La Mancha, Cobertizo de San Pedro Mártir s n, Toledo, Spain
    Health Econ 19:491-500. 2010
    ..This study explores the relationship between the employment status of human immunodeficiency virus (HIV)-positive individuals and socioeconomic and health characteristics in Spain...
  95. ncbi Deletion, insertion and stop codon mutations in vif genes of HIV-1 infecting slow progressor patients
    Héctor Rafael Rangel
    Laboratorio de Virologia Molecular, Centro de Microbiologia y Biologia Celular, Instituto Venezolano de Investigaciones Cientificas, Apdo 20632, Caracas 1020 A, Venezuela
    J Infect Dev Ctries 3:531-8. 2009
    ..Viral gene defects have been associated with the disease progression but more studies are still needed...
  96. ncbi Nef mutations in long-term non-progressors from former plasma donors infected with HIV-1 subtype B in China
    Shu Hua Wang
    State Key Laboratory for Infection Diseases Prevention and Control, National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
    Biomed Environ Sci 21:485-91. 2008
    ....
  97. ncbi Association of IL-12+ DC with High CD3+CD4-DR+ lymphocyte counts in long-term HIV-infected hemophilia patients with clinically stable disease
    Volker Daniel
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    J Clin Immunol 28:58-72. 2008
    ..These data suggest that long-term HIV-infected hemophilia patients with clinically stable disease have normal levels of functional IL-10(+) DC and IL-12(+) DC that might be involved in halting the progression of disease...
  98. ncbi Hardiness, successful aging, and HIV: implications for social work
    David E Vance
    Center for Nursing Research, School of Nursing, University of Alabama at Birmingham, 1701 University Boulevard, Suite G010B, 35294 1210, USA
    J Gerontol Soc Work 51:260-83. 2008
    ..Potential interventions and clinical implications for social work are posited for augmenting qualities of hardiness in people aging with HIV...
  99. pmc Hepatitis C infection in HIV-1 natural viral suppressors
    Mohammad M Sajadi
    Institute of Human Virology at the University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    AIDS 24:1689-95. 2010
    ..The objective of this study was to investigate whether HIV-infected NVSs also demonstrate enhanced ability to control hepatitis C virus (HCV) infection, and whether HCV infection in the NVSs affects the degree of HIV control...
  100. ncbi A very particular case of long-term non-progressor: nineteen consecutive years of follow-up in the absence of any detectable HIV-1 viraemia
    R Manfredi
    Division of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Bologna Alma Mater Studiorum, S Orsola Malpighi Hospital, Bologna, Italy
    Int J STD AIDS 19:784-5. 2008
    ....
  101. pmc Towards a combined prognostic index for survival in HIV infection: the role of 'non-HIV' biomarkers
    Amy C Justice
    Section of General Internal Medicine, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA
    HIV Med 11:143-51. 2010
    ..We ask whether 'non-HIV' biomarkers improve differentiation of mortality risk among individuals initiating combination antiretroviral therapy (cART)...

Research Grants46

  1. Minimal Levels of HIV-1 in Vaccinated & Exposed Persons
    Tuofu Zhu; Fiscal Year: 2007
    ..These studies should assist definition of virologic and immunologic characteristics required to attenuate and/or substantially control HIV-1 infection, a critical goal of AIDS vaccine development. ..
  2. Latent virus and HIV-1 specific immunity in LTNPs
    Joel Blankson; Fiscal Year: 2006
    ..Siliciano, and the supportive environment of the Johns Hopkins University will provide Dr. Blankson with the skills he needs to develop into an independent clinician and basic scientist researcher in HIV-1 pathogenesis. ..
  3. IMMUNOLOGIC & VIROLOGIC FEATURES OF EARLY HIV INFECTION
    Jay Levy; Fiscal Year: 2006
    ..The results should provide useful approaches for both industrialized and developing countries to improve the clinical outcome of infection and block HIV transmission. ..
  4. HIV-Infected IDU Living with HCV Coinfection
    Karolynn Siegel; Fiscal Year: 2005
    ..abstract_text> ..
  5. ACUTE INFECTION AND EARLY DISEASE RESEARCH NETWORK
    Joseph Margolick; Fiscal Year: 2003
    ..The data obtained will help define the optimal use of the new, potent therapies for HIV-1 infection, and will also help to understand the mechanism of immune system damage in HIV-l infection. ..
  6. Characterization of HIV excape mutants and T cell responses in elite suppressors
    Joel Blankson; Fiscal Year: 2007
    ..This may allow some patients to control the virus without antiretroviral therapy for prolonged periods of time. ..
  7. 20Years of HIV Research: From Discovery to Understanding
    Jay Levy; Fiscal Year: 2003
    ..The presentations will permit attendees to appreciate and to understand what approaches need to be done to control HIV infection itself as well as its consequences. ..
  8. ALCOHOL EFFECTS ON THYMIC IMMUNE RESPONSE TO HAART
    Maria Jose Miguez; Fiscal Year: 2004
    ..abstract_text> ..
  9. Pathogenesis of Macrophage Tropic HIV-1
    Paul Gorry; Fiscal Year: 2004
    ..Understanding the molecular basis of enhanced M-tropism will provide further insights into HIV-1 pathogenesis, which is vital for the development of new inhibitors for the treatment of HIV-1 infection. ..
  10. Modeling Sequential Antiretroviral Therapy in HIV
    Elena Losina; Fiscal Year: 2005
    ..This award will provide critical insight into the optimal strategies for managing HIV infection and will provide Dr. Losina with a solid foundation for development as an independent and productive investigator. ..
  11. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..Information from these analyses will be used in linear programming to predict how the described changes in nutrient content of milk due to heating would affect the overall dietary needs of the child and the associated costs. ..
  12. Immune Control of HIV in Children
    Margaret Feeney; Fiscal Year: 2006
    ..This research will be conducted under the guidance of leading investigators in the field of HIV immunopathogenesis in adults. ..
  13. Maximizing Opportunity - HIV Prevention in Hospitalized Russian Drinkers
    Jeffrey H Samet; Fiscal Year: 2010
    ..abstract_text> ..
  14. Feasibility and Pilot Efficacy of Flash-heated Breastmilk to Reduce Pediatric HIV
    Caroline Chantry; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Enhancing Alcohol Science Focus: AMERSA National Meeting
    Jeffrey Samet; Fiscal Year: 2008
    ..Since the Annual National Conference draws a large number of participants from a variety of medical and other healthcare professions, the impact on clinical training and practice will be substantial. ..
  16. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2010
    ..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
  17. New Model for NeuroAIDS Utilizing Monocyte-Derived HIV-1
    Tuofu Zhu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. MULTICENTER AIDS COHORT STUDY PATHOGENESIS RESEARCH
    Joseph Margolick; Fiscal Year: 2003
    ..Results from these studies should help to improve understanding of a) mechanisms influencing the rate of HIV-1 disease progression and b) optimal ways to balance the benefits and risks of HAART. ..
  19. Effect of DC-SIGNR Polymorphisms on HIV-1 Infection
    Tuofu Zhu; Fiscal Year: 2003
    ..These studies should assist in the identification of new therapeutic targets and strategies to protect against HIV-1 transmission and control disease progression. ..
  20. Inducible Cellular Resistance to HIV-1 infection.
    Malgorzata Simm; Fiscal Year: 2003
    ....
  21. MEDICATION ADHERENCE IN ALCOHOL ABUSING HIV PATIENTS
    Jeffrey Samet; Fiscal Year: 2001
    ..The ADHERE study will enable us to develop a generalizable intervention to enhance antiretroviral medication adherence in patients with a history of alcohol abuse and test its efficacy in terms of important clinical outcomes. ..
  22. HRF, an NFkB antagonist targeting multiple pathogenes
    Malgorzata Simm; Fiscal Year: 2008
    ..This program will result in the development of a new broad spectrum immunotherapeutic based upon a human protein for the control of NFkB-directed acute inflammatory responses to multiple pathogens. [unreadable] [unreadable]..
  23. CLINICAL IMPACT ON HCV & ALCOHOL IN HIV INFECTED PERSONS
    Jeffrey Samet; Fiscal Year: 2004
    ..The results of this study will provide crucial information needed for the development and prioritization of interventions for coinfected persons with addictions. ..
  24. HIV Prevention Partnership in Russian Alcohol Treatment
    Jeffrey Samet; Fiscal Year: 2005
    ..Many will be HIV infected. Thus, the successful implementation of this study will provide a critical foundation for future prevention efforts to address the explosion of HIV infection in Russia. ..
  25. Alcohol Associated Outcomes Among HIV+/-Aging Veterans
    Amy Justice; Fiscal Year: 2002
    ..After completing baseline enrollment, follow up will occur at 6-month intervals and new patients will be enrolled as they present for care. ..
  26. A randomized trial of HAART in acute/early HIV Infection
    Joseph Margolick; Fiscal Year: 2008
    ..Comparison with untreated subjects carrying susceptible isolates will allow us to evaluate the contribution (positive or negative) of primary drug resistance on HIV disease progression. ..
  27. MEDIATORS OF AGE ASSOCIATED OUTCOMES IN HIV INFECTION
    Amy Justice; Fiscal Year: 2002
    ..By virtue of the requested support, the applicant believes she will gain the experience and insight needed to conduct multidisciplinary interventional studies to improve outcomes for middle-aged and older people with HIV. ..
  28. SELF-CARE IN SYMPTOM MANAGEMENT AT THE END OF LIFE
    Karolynn Siegel; Fiscal Year: 2002
    ..Specifically we will investigate: 1) the symptom appraisal process; 2) coping responses to common symptoms: 3) the kinds of self-care activities employed; 4) emotional responses to common symptoms. ..
  29. Clinical Impact of Drug Use in HIV-Infected Persons: A Pilot Study
    Jeffrey Samet; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. Knee OA: Setting Priorities for Care, Policy, Research
    Elena Losina; Fiscal Year: 2010
    ..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..
  31. ENHANCED LINKAGE OF DRUG ABUSERS TO PRIMARY MEDICAL CARE
    Jeffrey H Samet; Fiscal Year: 2010
    ..Improved outcomes using the AHEAD approach would support the adoption of a health services delivery strategy, CDM, to better care for patients with DD. ..
  32. A Novel Model for the Study of Lung Pathogenesis of SARS
    Linqi Zhang; Fiscal Year: 2008
    ..These methods are repeatedly used to support each of the aims. ..
  33. Symptom Interpretation & Oral Health among Harlem Adults
    Karolynn Siegel; Fiscal Year: 2005
    ..In depth face-to-face, focused interviews will be conducted with 120 adults. As in several of the principal Investigator's previous federally funded investigations, qualitative research methods will be employed. ..
  34. Role of CD14+ Monocytes in HIV-1 Infection
    Tuofu Zhu; Fiscal Year: 2005
    ..Findings from this proposal will provide better understanding of productive infection of HIV-1 in CD 14+ monocytes in vivo, and may also provide great insights to developing new therapeutic strategies to enhance therapy efficacy. ..
  35. Motivational Therapy/Reduce Risk Behaviors/HIV/Youth
    Sylvie Naar King; Fiscal Year: 2003
    ..If successful, this intervention will provide immediate assistance to vulnerable population to prevent the spread of HIV and to minimize its negative physical and psychological effects. ..
  36. CONTRIBUTION OF THE THYMUS TO SIV PATHOGENESIS
    Linqi Zhang; Fiscal Year: 2003
    ....
  37. INNATE HOST DEFENSE IN THE HUMAN VAGINA
    Tomas Ganz; Fiscal Year: 2004
    ..abstract_text> ..
  38. Macrophage-mediated delivery of HIV-1 Vaccine
    Malgorzata Simm; Fiscal Year: 2005
    ..The long-term goal of this project is to employ HRF as a novel inhibitor of both HIV replication and inflammation in the brain. ..
  39. MSMW: Pathways, Motives and Behaviors
    Karolynn Siegel; Fiscal Year: 2009
    ..The study's finding will offer novel and important information about a high risk subpopulation of MSMW, and will yield important information that can guide the development of preventive interventions. ..
  40. Human Defensins in Phagocytes and Epithelia
    Tomas Ganz; Fiscal Year: 2004
    ..In the aggregate, these studies will expand our understanding of is ubiquitous and multifunctional family of human host defense peptides, this time also in their role as effectors of innate immunity in epithelia. ..
  41. SYMPTOMS AND ILLNESS BEHAVIORS OF HIV-INFECTED ADULTS
    Karolynn Siegel; Fiscal Year: 2002
    ..All of which are important factors in adapting to life with what may become a chronic illness as more people live longer with the infection and do so within the context of a rapidly changing health care system. ..
  42. The role of hemojuvelin in the regulation of iron metabolism
    Tomas Ganz; Fiscal Year: 2007
    ..unreadable] [unreadable]..