Summary: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)

Top Publications

  1. ncbi Abnormal brain structure implicated in stimulant drug addiction
    Karen D Ersche
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Science 335:601-4. 2012
  2. ncbi Sibling comparison designs: bias from non-shared confounders and measurement error
    Thomas Frisell
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 23:713-20. 2012
  3. pmc Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings
    Peter M Visscher
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 2:e41. 2006
  4. pmc Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study
    Sally Ozonoff
    Department of Psychiatry, University of California Davis, Sacramento, California 95817, USA
    Pediatrics 128:e488-95. 2011
  5. ncbi Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Geriatr Soc 57:1634-7. 2009
  6. pmc Sibling recurrence and the genetic epidemiology of autism
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 167:1349-56. 2010
  7. ncbi Behavioral manifestations of autism in the first year of life
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster Children s Hospital, McMaster University, PO Box 2000, Hamilton, Ont, Canada L8N 3Z5
    Int J Dev Neurosci 23:143-52. 2005
  8. pmc Visual orienting in the early broader autism phenotype: disengagement and facilitation
    Mayada Elsabbagh
    Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK
    J Child Psychol Psychiatry 50:637-42. 2009
  9. pmc Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence
    Karen D Ersche
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Am J Psychiatry 169:926-36. 2012
  10. pmc Brain network connectivity in individuals with schizophrenia and their siblings
    Grega Repovs
    Department of Psychology, University of Ljubljana, Ljubljana, Slovenia
    Biol Psychiatry 69:967-73. 2011

Detail Information

Publications300 found, 100 shown here

  1. ncbi Abnormal brain structure implicated in stimulant drug addiction
    Karen D Ersche
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Science 335:601-4. 2012
    ..brain systems implicated in self-control in both stimulant-dependent individuals and their biological siblings who have no history of chronic drug abuse; these findings support the idea of an underlying neurocognitive ..
  2. ncbi Sibling comparison designs: bias from non-shared confounders and measurement error
    Thomas Frisell
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 23:713-20. 2012
    Twins, full siblings, and half-siblings are increasingly used as comparison groups in matched cohort and matched case-control studies...
  3. pmc Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings
    Peter M Visscher
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Genet 2:e41. 2006
  4. pmc Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study
    Sally Ozonoff
    Department of Psychiatry, University of California Davis, Sacramento, California 95817, USA
    Pediatrics 128:e488-95. 2011
    ..This study used prospective methods to obtain an updated estimate of sibling recurrence risk for ASD...
  5. ncbi Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Geriatr Soc 57:1634-7. 2009
    To compare the risk of mortality of nonagenarian siblings with that of sporadic nonagenarians (not selected on having a nonagenarian sibling) and to compare the prevalence of morbidity in their offspring with that of the offsprings' ..
  6. pmc Sibling recurrence and the genetic epidemiology of autism
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 167:1349-56. 2010
    Although the symptoms of autism exhibit quantitative distributions in nature, estimates of recurrence risk in families have never previously considered or incorporated quantitative characterization of the autistic phenotype among siblings.
  7. ncbi Behavioral manifestations of autism in the first year of life
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster Children s Hospital, McMaster University, PO Box 2000, Hamilton, Ont, Canada L8N 3Z5
    Int J Dev Neurosci 23:143-52. 2005
    ..Our sample currently includes 150 infant siblings, including 65 who have been followed to age 24 months, who are the focus of this paper...
  8. pmc Visual orienting in the early broader autism phenotype: disengagement and facilitation
    Mayada Elsabbagh
    Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK
    J Child Psychol Psychiatry 50:637-42. 2009
    Recent studies of infant siblings of children diagnosed with autism have allowed for a prospective approach to examine the emergence of symptoms and revealed behavioral differences in the broader autism phenotype within the early years...
  9. pmc Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence
    Karen D Ersche
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Am J Psychiatry 169:926-36. 2012
  10. pmc Brain network connectivity in individuals with schizophrenia and their siblings
    Grega Repovs
    Department of Psychology, University of Ljubljana, Ljubljana, Slovenia
    Biol Psychiatry 69:967-73. 2011
  11. ncbi Revisiting causal neighborhood effects on individual ischemic heart disease risk: a quasi-experimental multilevel analysis among Swedish siblings
    Juan Merlo
    Faculty of Medicine, Lund University, Skane University Hospital, Jan Waldenströms Street 35, 20502 Malmo, Sweden
    Soc Sci Med 76:39-46. 2013
    ..In contrast the high family level VPC = 20.1% confirms the relevance of the family context for understanding IHD risk...
  12. ncbi Parent-infant interaction in infant siblings at risk of autism
    Ming Wai Wan
    University of Manchester, UK
    Res Dev Disabil 33:924-32. 2012
    ..As part of the British Autism Study of Infant Siblings (BASIS), 6-min videotaped unstructured play interactions of mother-infant dyads (45 at-risk sibs and 47 low-risk ..
  13. pmc Strong association of de novo copy number mutations with autism
    Jonathan Sebat
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 316:445-9. 2007
    ..Affected genomic regions were highly heterogeneous and included mutations of single genes. These findings establish de novo germline mutation as a more significant risk factor for ASD than previously recognized...
  14. ncbi Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls
    Ivan K S Yap
    Biomolecular Medicine, Division of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London, United Kingdom
    J Proteome Res 9:2996-3004. 2010
    ..with autism using the DSM-IV-TR criteria (n = 39; male = 35; female = 4), together with their nonautistic siblings (n = 28; male = 14; female = 14) and age-matched healthy volunteers (n = 34, male = 17; female = 17) have been ..
  15. pmc Smoking during pregnancy and offspring externalizing problems: an exploration of genetic and environmental confounds
    Brian M D'Onofrio
    Indiana University, Bloomington, IN 47405, USA
    Dev Psychopathol 20:139-64. 2008
    ..When offspring were compared to their own siblings who differed in their exposure to prenatal nicotine, there was no effect of SDP on offspring CP and ODP...
  16. pmc Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs
    V Gupta
    South Asia Network for Chronic Disease, Public Health Foundation of India, C 1 52, Safdarjung Development Area, New Delhi 110016, India
    Diabetologia 55:349-57. 2012
    ..Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population...
  17. ncbi Psycho-educational interventions for children with chronic disease, parents and siblings: an overview of the research evidence base
    J H Barlow
    Interdisciplinary Research Centre in Health, School of Health and Social Sciences, Coventry University, Coventry, UK
    Child Care Health Dev 30:637-45. 2004
    ..The purpose of this paper is to provide an overview of the current literature regarding the effectiveness of psycho-educational interventions for children and adolescents with chronic disease, their parents and siblings.
  18. ncbi Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian children who participated in a 9-valent pneumococcal conjugate vaccine trial and in their younger siblings
    Yin Bun Cheung
    Biostatistics Department, Singapore Clinical Research Institute, Singapore
    Pediatr Infect Dis J 28:990-5. 2009
    ..We studied the effects of vaccination with pneumococcal conjugate vaccines on the carriage of individual serotypes and on antimicrobial resistance in vaccinated children and their younger siblings.
  19. pmc Neural signatures of autism
    Martha D Kaiser
    Yale Child Study Center, Yale School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:21223-8. 2010
    ..imaging of brain responses to biological motion in children with autism spectrum disorder (ASD), unaffected siblings (US) of children with ASD, and typically developing (TD) children has revealed three types of neural signatures: (..
  20. pmc Strong hepatitis C virus (HCV)-specific cell-mediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children
    Mohamed Hashem
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 203:854-61. 2011
    ..We investigated HCV-specific CMI responses in seronegative children living with HCV-infected siblings.
  21. pmc Out of the mouths of babes: vocal production in infant siblings of children with ASD
    Rhea Paul
    Yale Child Study Center, USA Southern Connecticut State University, USA
    J Child Psychol Psychiatry 52:588-98. 2011
    Younger siblings of children with autism spectrum disorders (ASD) are at higher risk for acquiring these disorders than the general population. Language development is usually delayed in children with ASD...
  22. ncbi Potential risk for healthy siblings to develop schizophrenia: evidence from pattern classification with whole-brain connectivity
    Meijie Liu
    College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, People s Republic of China
    Neuroreport 23:265-9. 2012
    ..e. patients diagnosed with schizophrenia, healthy siblings, and healthy controls after preprocessing), resulting in an 80...
  23. ncbi A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism
    M G Teles
    Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42 da Disciplina de Endocrinologia, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, 05403 900 Sao Paulo, Brazil
    Eur J Endocrinol 163:29-34. 2010
    ..Loss-of-function mutations of the kisspeptin-1 receptor gene, KISS1R, have been identified in patients with normosmic isolated hypogonadotropic hypogonadism (nIHH)...
  24. ncbi Selective gender differences in childhood nutrition and immunization in rural India: the role of siblings
    Rohini P Pande
    International Center for Research on Women, 1717 Massachusetts Avenue, NW, Suite 302, Washington, DC 20036, USA
    Demography 40:395-418. 2003
    This article examines the role of the sex composition of surviving older siblings on gender differences in childhood nutrition and immunization, using data from the National Family Health Survey, India (1992-1993)...
  25. pmc What are infant siblings teaching us about autism in infancy?
    Sally J Rogers
    MIND Institute, University of California Davis, Sacramento, USA
    Autism Res 2:125-37. 2009
    ..disorders (ASDs) has recently focused on a research paradigm involving prospective longitudinal studies of infant siblings of children with autism...
  26. pmc Reaction time performance in ADHD: improvement under fast-incentive condition and familial effects
    Penny Andreou
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 37:1703-15. 2007
    ..Using a group familial correlation approach, we tested the hypothesis that there are shared familial effects on RT performance and ADHD...
  27. pmc Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29
    Ming Chang Chiang
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7332, USA
    Neuroimage 54:2308-17. 2011
    ..integrity voxelwise using diffusion tensor imaging at high magnetic field (4-Tesla), in 705 twins and their siblings (age range 12-29; 290 M/415 F)...
  28. ncbi Stress-induced responses of human skin fibroblasts in vitro reflect human longevity
    Pim Dekker
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Aging Cell 8:595-603. 2009 skin fibroblasts that were isolated from young and very old subjects, and from offspring of nonagenarian siblings and their partners, representatives of the general population...
  29. ncbi Parents, siblings and grandparents in the Neonatal Intensive Care Unit. A survey of policies in eight European countries
    Gorm Greisen
    Neonatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 98:1744-50. 2009
    ..To describe policies towards family visiting in Neonatal Intensive Care Units (NICU) and compare findings with those of a survey carried out 10 years earlier...
  30. ncbi Decreased left middle temporal gyrus volume in antipsychotic drug-naive, first-episode schizophrenia patients and their healthy unaffected siblings
    Maorong Hu
    Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, PR China
    Schizophr Res 144:37-42. 2013
    The shared neuropathological characteristics of patients with schizophrenia and their siblings might represent intermediate phenotypes that could be used to investigate genetic susceptibility to the illness...
  31. ncbi Concordant fetal hemoglobin response to hydroxyurea in siblings with sickle cell disease
    Martin H Steinberg
    Boston University School of Medicine, Room 211, 88 E Newton Street, Boston, MA 02118, USA
    Am J Hematol 72:121-6. 2003
    ..We hypothesized that siblings with sickle cell disease are likely to share the same parental beta-like globin gene clusters with their cis-..
  32. ncbi Clinical characterisation of the multiple maternal hypomethylation syndrome in siblings
    Susanne E Boonen
    Genetic Counselling Clinic, Kennedy Center, Glostrup, Denmark
    Eur J Hum Genet 16:453-61. 2008
    ..The recurrence with affected sibs as reported in this family has implications for genetic counselling...
  33. ncbi Childhood trauma and psychosis: a case-control and case-sibling comparison across different levels of genetic liability, psychopathology, and type of trauma
    Manuela Heins
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands
    Am J Psychiatry 168:1286-94. 2011
    ..The associations of two types of childhood trauma (abuse and neglect) with psychosis symptom domains were investigated in subjects with psychotic illness, high psychosis vulnerability, and average psychosis vulnerability...
  34. pmc Adult global DNA methylation in relation to pre-natal nutrition
    L H Lumey
    Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA
    Int J Epidemiol 41:116-23. 2012
    ..There have been no studies to date of the relation between pre-natal famine and overall global DNA methylation in adulthood...
  35. ncbi Prepregnancy body mass index and gestational weight gain in relation to child body mass index among siblings
    Amy M Branum
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Road, Hyattsville, MD 20782, USA
    Am J Epidemiol 174:1159-65. 2011
    ..Future studies should continue to evaluate the relative roles of important familial and environmental factors that may influence BMI and obesity in children...
  36. ncbi Acquisition of Helicobacter pylori infection in early childhood: independent contributions of infected mothers, fathers, and siblings
    Maria Weyermann
    Department of Clinical Epidemiology and Aging Research, The German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 104:182-9. 2009
    Infected siblings, mothers, and fathers have all been suggested to be major sources for Helicobacter pylori acquisition among children, but few studies have addressed the potential role of various family members simultaneously.
  37. ncbi Adult mortality from sibling survival data: a reappraisal of selection biases
    Bruno Masquelier
    Université Catholique de Louvain and Belgian National Fund for Scientific Research, Louvain la Neuve, Belgium
    Demography 50:207-28. 2013
    ..Under most circumstances, corrections for selection biases should have only a modest effect on sibling estimates...
  38. ncbi Studying the emergence of autism spectrum disorders in high-risk infants: methodological and practical issues
    Lonnie Zwaigenbaum
    Department of Paediatrics, McMaster Children s Hospital at McMaster University, Hamilton, Ontario, Canada
    J Autism Dev Disord 37:466-80. 2007
    ..Several research groups have initiated prospective studies of high-risk populations including infant siblings, to systematically collect data on early signs within a longitudinal design...
  39. pmc ABCA4 mutations and discordant ABCA4 alleles in patients and siblings with bull's-eye maculopathy
    M Michaelides
    Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Br J Ophthalmol 91:1650-5. 2007
    ..To determine the frequency and nature of mutations in the gene ABCA4 in a cohort of patients with bull's-eye maculopathy (BEM)...
  40. pmc Social network concordance in food choice among spouses, friends, and siblings
    Mark A Pachucki
    University of California, Berkeley, School of Public Health, Berkeley, CA 94720 7360, USA
    Am J Public Health 101:2170-7. 2011
    ..We investigated whether eating behaviors were concordant among diverse sets of social ties...
  41. pmc Number of siblings, birth order, and childhood overweight: a population-based cross-sectional study in Japan
    Hirotaka Ochiai
    Department of Public Health, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    BMC Public Health 12:766. 2012
    Although several studies have investigated the relationship between the number of siblings or birth order and childhood overweight, the results are inconsistent...
  42. ncbi Resting-state brain activity in major depressive disorder patients and their siblings
    Chun hong Liu
    Department of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China
    J Affect Disord 149:299-306. 2013
  43. pmc Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation
    Despina Moshous
    Inserm U768, Paris, France
    J Allergy Clin Immunol 131:1594-603. 2013
    ..We evaluated 3 siblings from a consanguineous family presenting with EBV-associated B-cell lymphoproliferation at an early age (12, 7½, ..
  44. pmc Separation of cognitive impairments in attention-deficit/hyperactivity disorder into 2 familial factors
    Jonna Kuntsi
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Arch Gen Psychiatry 67:1159-67. 2010
    ..A better understanding of the etiological pathways is important for the development of targeted interventions and for identification of suitable intermediate phenotypes for molecular genetic investigations...
  45. pdf The development of siblings of children with autism at 4 and 14 months: social engagement, communication, and cognition
    Nurit Yirmiya
    Department of Psychology and School of Education, Hebrew University of Jerusalem, Mount Scopus, Israel
    J Child Psychol Psychiatry 47:511-23. 2006
    To compare siblings of children with autism (SIBS-A) and siblings of children with typical development (SIBS-TD) at 4 and 14 months of age.
  46. ncbi Birth order, sibling sex ratio, handedness, and sexual orientation of male and female participants in a BBC internet research project
    Ray Blanchard
    Centre for Addiction and Mental Health, Law and Mental Health Program, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Arch Sex Behav 36:163-76. 2007
    ..In subsequent analyses, participants were divided into those who did and did not have younger siblings, on the grounds that the data of the former would be less contaminated by the stopping rule...
  47. ncbi Siblings of Okinawan centenarians share lifelong mortality advantages
    Bradley J Willcox
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    J Gerontol A Biol Sci Med Sci 61:345-54. 2006
    ..We analyzed the pedigrees of 348 centenarian families with 1142 siblings and compared sibling survival with that of the 1890 Okinawan general population cohort...
  48. ncbi Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients
    Valma Harjutsalo
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Diabetes 54:563-9. 2005
    The aims of our analysis were to obtain the empirical risk estimates for type 1 diabetes in the siblings of a Finnish population-based cohort of childhood-onset diabetic patients and search for demographic and other factors predicting the ..
  49. pmc Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients
    Anand Mattai
    Child Psychiatry Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Psychiatry 168:427-35. 2011
    ..In the present study, the authors examined hippocampal volumes in relation to age for patients with childhood-onset schizophrenia, their nonpsychotic healthy siblings, and healthy comparison subjects.
  50. ncbi Is maternal smoking during pregnancy a risk factor for hyperkinetic disorder?--Findings from a sibling design
    Carsten Obel
    Department of General Practice, School of Public Health, Aarhus University, Denmark
    Int J Epidemiol 40:338-45. 2011
    ..However, social and genetic confounders may fully or partially account for these findings...
  51. pmc Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 95:14-22. 2008
    The purpose of this study was to examine substance use and dependence among cocaine dependent subjects and their siblings compared to individuals recruited from the same neighborhood and their siblings in order to better understand family ..
  52. ncbi Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings
    Sarah Durston
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Acad Child Adolesc Psychiatry 43:332-40. 2004
    ..To study the influence of increased familial risk for attention-deficit/hyperactivity disorder (ADHD) on brain morphology...
  53. ncbi Victimization over the life span: a comparison of lesbian, gay, bisexual, and heterosexual siblings
    Kimberly F Balsam
    Department of Psychology, University of Washington, Seattle, WA 98195, USA
    J Consult Clin Psychol 73:477-87. 2005
    ..were recruited via LGB e-mail lists, periodicals, and organizations; these participants recruited 1 or more siblings for participation in the study (81% heterosexual, 19% LGB)...
  54. ncbi Elevated cerebrospinal fluid F2-isoprostane levels indicating oxidative stress in healthy siblings of multiple sclerosis patients
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgren s University Hospital, S 431 80 Molndal, Sweden
    Neurosci Lett 414:233-6. 2007
    ..examines the levels of cerebrospinal fluid (CSF) F2-isoprostanes (F2-iPs) in MS patients (n=46), their healthy siblings (n=46) and unrelated controls (n=50)...
  55. ncbi Adult mortality in sub-Saharan Africa: evidence from Demographic and Health Surveys
    Ian M Timaeus
    Centre for Population Studies, London School of Hygiene and Tropical Medicine LSHTM, Keppel Street, London WC1E 7HT, United Kingdom
    Demography 41:757-72. 2004
    ..It is time for a systematic attempt to reconcile the demographic and epidemiological evidence concerning AIDS in Africa...
  56. ncbi Death by survey: estimating adult mortality without selection bias from sibling survival data
    Emmanuela Gakidou
    Institute for Quantitative Social Science, Harvard University, Cambridge, MA 02138, USA
    Demography 43:569-85. 2006
    The widely used methods for estimating adult mortality rates from sample survey responses about the survival of siblings, parents, spouses, and others depend crucially on an assumption that, as we demonstrate, does not hold in real data...
  57. ncbi Early language and communication development of infants later diagnosed with autism spectrum disorder
    Shelley Mitchell
    Autism Research Unit, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Dev Behav Pediatr 27:S69-78. 2006, we prospectively collected parent report data on early communication and language development in 97 infant siblings of children with ASD and 49 low-risk controls...
  58. ncbi Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study
    Melissa M Hudson
    Department of Hematology Oncology, St Jude Children s Research Hospital and the University of Tennessee College of Medicine, Memphis 38105, USA
    JAMA 290:1583-92. 2003
    ..Adult survivors of childhood cancer are at risk for medical and psychosocial sequelae that may adversely affect their health status...
  59. ncbi Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings
    Robert A Power
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, England
    JAMA Psychiatry 70:22-30. 2013
    ..However, this is key to understanding their etiology and designing studies to identify risk variants...
  60. ncbi Sibling phenotype concordance in classical infantile Pompe disease
    Wendy E Smith
    Division of Genetics, The Barbara Bush Children s Hospital, Maine Medical Center, Portland, Maine, USA
    Am J Med Genet A 143:2493-501. 2007
    ..The age at symptom onset, age at death, and clinical course were compared between probands and affected siblings. Our results showed that since 1931, publications document 13 families with 31 affected infants (11 probands; 20 ..
  61. ncbi A novel deletion-insertion mutation identified in exon 3 of FXN in two siblings with a severe Friedreich ataxia phenotype
    Marguerite V Evans-Galea
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Flemington Road, Parkville, Victoria 3052, Australia
    Neurogenetics 12:307-13. 2011
    ..Two siblings with early onset of symptoms experienced rapid loss of ambulation by 8 and 10 years...
  62. pmc Identification of genetically mediated cortical networks: a multivariate study of pediatric twins and siblings
    J E Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics Richmond, VA 23298, USA
    Cereb Cortex 18:1737-47. 2008
    Structural magnetic resonance imaging data from 308 twins, 64 singleton siblings of twins, and 228 singletons were analyzed using structural equation modeling and selected multivariate methods to identify genetically mediated ..
  63. pmc Behavioral profiles of affected and unaffected siblings of children with autism: contribution of measures of mother-infant interaction and nonverbal communication
    Agata Rozga
    Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    J Autism Dev Disord 41:287-301. 2011 social gaze and affect and in joint attention behaviors are evident within the first year of life among siblings of children with autism who go on to be diagnosed with autism or ASD (ASD) and siblings who are non-diagnosed (..
  64. ncbi Two adult siblings with atypical cryopyrin-associated periodic syndrome due to a novel M299V mutation in NLRP3
    Deepti Verma
    Division of Cell Biology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Arthritis Rheum 62:2138-43. 2010
    ..The aim of this study was to report a novel NLRP3 mutation in 2 siblings of Swedish descent in whom symptoms first presented in adulthood.
  65. ncbi Molecular characterisation of gastrointestinal microbiota of children with autism (with and without gastrointestinal dysfunction) and their neurotypical siblings
    Shakuntla V Gondalia
    Swinburne Autism Bio Research Initiative SABRI, Faculty of Life and Social Sciences, Swinburne University of Technology, Hawthorn, Victoria, Australia
    Autism Res 5:419-27. 2012
    ..without gastrointestinal dysfunction: n = 23; with gastrointestinal dysfunction: n = 28) and their neurotypical siblings (n = 53) who share a similar environment using bacterial tag-encoded FLX amplicon pyrosequencing...
  66. ncbi Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2: clinical features and (99m)Tc-ECD brain perfusion SPECT findings
    Hiroshi Doi
    Department of Clinical Neurology and Stroke Medicine, Yokohama City University, Japan
    J Neurol Sci 290:172-6. 2010
    ..The adult-onset slowly progressive type of PKAN with PANK2 mutations is very rare. In this report, we describe siblings with the adult-onset slowly progressive type of PKAN with a novel mutation, Ile346Ser, in PANK2...
  67. ncbi Cognitive functioning in siblings discordant for schizophrenia
    C Hughes
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Acta Psychiatr Scand 111:185-92. 2005
    The objective of this study was to investigate neuropsychological impairment as a genetically mediated risk indicator for schizophrenia while accounting for prevalence of schizotypy signs/symptoms in siblings.
  68. pmc Family risk and related education and counseling needs: perceptions of adults with bipolar disorder and siblings of adults with bipolar disorder
    H L Peay
    Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892 2073, USA
    Am J Med Genet A 149:364-71. 2009
    ..conducting semi-structured interviews (n = 48) with individuals with bipolar disorder (BPD) and unaffected siblings. Content analysis generated descriptive data that provide guidance for clinical interventions and themes to ..
  69. pmc Functional health status of adolescents after the Fontan procedure -- comparison with their siblings
    Cedric Manlhiot
    Division of Cardiology, Labatt Family Heart Centre, Toronto, Canada
    Can J Cardiol 25:e294-300. 2009
    ..Studies have suggested that patients who have undergone the Fontan procedure experience lower functional health status and diminished exercise capacity compared with other children...
  70. ncbi Understanding the experiences and service needs of siblings of individuals with first-episode psychosis: a phenomenological study
    Jacqueline Sin
    Berkshire Healthcare NHS Foundation Trust, Bracknell, UK
    Early Interv Psychiatry 6:53-9. 2012
    Despite recent focus on developing family-inclusive services to meet the needs of young people with first-episode psychosis, the needs of their siblings are often overlooked.
  71. ncbi Altered antioxidant defense system in clinically stable patients with schizophrenia and their unaffected siblings
    Leila Ben Othmen
    Research Laboratory Trace Elements, Free Radicals and Antioxidants, Biophysics Department, Faculty of Medicine, 5000 Monastir, Tunisia
    Prog Neuropsychopharmacol Biol Psychiatry 32:155-9. 2008
    To determine Red Blood Cell (RBC) antioxidant enzyme activities and plasma Thiobarbituric Acid Reactive Substances (TBARS) in clinically stable patients with schizophrenia and their unaffected siblings.
  72. ncbi Mental health of lesbian, gay, bisexual, and heterosexual siblings: effects of gender, sexual orientation, and family
    Kimberly F Balsam
    Department of Psychology, University of Washington, Seattle, WA 98195, USA
    J Abnorm Psychol 114:471-6. 2005
    ..male, and bisexual (LGB) individuals were recruited via convenience sampling, and they in turn recruited their siblings (79% heterosexual, 19% LGB)...
  73. ncbi [Obesity in children and adolescents and their parents. Correlation of standardized body mass index between patients, their parents and siblings from the multicentre APS data]
    M Robl
    Pädiatrie 2, Universitäts Kinderklinik Göttingen, Gottingen
    Dtsch Med Wochenschr 133:2448-53. 2008
    ..Genetic as well as environmental factors are important in the etiology of obesity. The aim of this multicentre study was to correlate the weight of overweight or obese children and adolescents with that of their parents and siblings.
  74. ncbi Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings
    Maria Cristina Vigone
    Department of Pediatrics, Endocrine Unit, Vita Salute San Raffaele University, Milan, Italy
    Hum Mutat 26:395. 2005
    ..Reevaluation at 4 years confirmed a persistent hyperthyrotropinemia associated with PIOD. Both siblings resulted compound heterozygotes for two novel DUOX2 variants, a nonsense mutation (c.2524C>T, p...
  75. pmc Adolescent siblings of individuals with an autism spectrum disorder: testing a diathesis-stress model of sibling well-being
    Gael I Orsmond
    Department of Occupational Therapy, Boston University, 635 Commonwealth Ave, Boston, MA 02215, USA
    J Autism Dev Disord 39:1053-65. 2009
    The purpose of this study was to test a diathesis-stress model of well-being for siblings who have a brother or sister with an autism spectrum disorder (ASD). Data were collected from 57 adolescents and their mothers...
  76. ncbi Familial risks for cervical tumors in full and half siblings: etiologic apportioning
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg
    Cancer Epidemiol Biomarkers Prev 15:1413-4. 2006
    ..Full and half-siblings were identified from the nationwide Swedish Family-Cancer Database, including invasive and in situ cervical ..
  77. pmc Magnetic resonance imaging traits in siblings discordant for Alzheimer disease
    Karen T Cuenco
    Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA 02118, USA
    J Neuroimaging 18:268-75. 2008
    ..We evaluated semi-quantitative MRI measures as endophenotypes for genetic studies by assessing their association with AD in families from the Multi-Institutional Research in Alzheimer Genetic Epidemiology (MIRAGE) Study...
  78. pmc Evolution of highly polymorphic T cell populations in siblings with the Wiskott-Aldrich Syndrome
    Maxim I Lutskiy
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3444. 2008
  79. ncbi Birth weight and cognitive ability in childhood among siblings and nonsiblings
    Seungmi Yang
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
    Pediatrics 122:e350-8. 2008
    ..was to examine whether the positive association between birth weight and childhood cognitive ability is seen within siblings from the same family, as well as between nonsiblings, and to determine whether these associations vary with age.
  80. ncbi Perrault syndrome with Marfanoid habitus in two siblings
    Jubbin J Jacob
    Department of Endocrinology, Christian Medical College and Hospital, Vellore, India
    J Pediatr Adolesc Gynecol 20:305-8. 2007
    ..The spectrum of the disease remains undetermined. Families with additional newer findings are regularly reported...
  81. ncbi Plasma cytokine levels in children with autistic disorder and unrelated siblings
    A M Manzardo
    Department of Psychiatry and Behavioral Sciences and Pediatrics, Kansas University Medical Center, Kansas City, KS 66160, USA
    Int J Dev Neurosci 30:121-7. 2012
    ..have been reported in AD including cytokines encoded by genes involved with cell proliferation, migration and adhesion but there is a paucity of data comparing cytokine levels in children with AD and unrelated siblings without AD.
  82. pmc Cross-sectional and longitudinal comparisons of the predominant fecal microbiota compositions of a group of pediatric patients with cystic fibrosis and their healthy siblings
    Gwen Duytschaever
    Faculty of Sciences, Laboratory of Microbiology, K L Ledeganckstraat 35, 9000 Ghent, Belgium
    Appl Environ Microbiol 77:8015-24. 2011
    ..DGGE) of 16S rRNA amplicons, we compared the predominant fecal microbiota of 21 patients with CF and 24 healthy siblings in a cross-sectional study...
  83. pmc Better working memory for non-social targets in infant siblings of children with Autism Spectrum Disorder
    Julia S Noland
    Department of Psychology and Human Development, Peabody, Box 552, 230 Appleton Place, Vanderbilt University, Nashville, TN 37203 5701, USA
    Dev Sci 13:244-51. 2010
    We compared working memory (WM) for the location of social versus non-social targets in infant siblings of children with Autism Spectrum Disorders (sibs-ASD, n = 25) and of typically developing children (sibs-TD, n = 30) at 6...
  84. pmc Heritability of cardiovascular and personality traits in 6,148 Sardinians
    Giuseppe Pilia
    Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Ospedale Microcitemico, Cagliari, Italy
    PLoS Genet 2:e132. 2006
    ..Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits...
  85. pmc Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network
    Haihong Liu
    Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, People s Republic of China
    Schizophr Bull 38:285-94. 2012
    ..Comparisons between schizophrenic patients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology...
  86. ncbi Siblings and family environments of persons with autism spectrum disorder: a review of the literature
    Laura O Smith
    College of Nursing, University of Florida, Gainesville, Florida, USA
    J Child Adolesc Psychiatr Nurs 23:189-95. 2010
    The purpose of this literature review is to summarize studies on siblings of individuals with autism spectrum disorders (ASD) in four major areas, to identify gaps in the literature, and to propose future directions for research of ..
  87. pmc The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians
    Alberto Montesanto
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 19:882-6. 2011
    Many epidemiological studies have shown that parents, siblings and offspring of long-lived subjects have a significant survival advantage when compared with the general population...
  88. ncbi Neuropsychological performance and auditory event related potentials in schizophrenia patients and their siblings: a family study
    Ali Emre Sevik
    Baskent University, Faculty of Medicine, Department of Psychiatry, Ankara, Turkey
    Schizophr Res 130:195-202. 2011
    ..The aims of this study were to compare cognitive and P300/MMN measurements in schizophrenia patients, their siblings, and controls, and to identify the degree of familial influence on each measure.
  89. pmc Opposite-sex siblings decrease attraction, but not prosocial attributions, to self-resembling opposite-sex faces
    Lisa M DeBruine
    School of Psychology, University of Aberdeen, Aberdeen AB24 3FX, United Kingdom
    Proc Natl Acad Sci U S A 108:11710-4. 2011
    ..maternal-perinatal association, modulate prosocial and inbreeding-avoidance behaviors toward specific potential siblings. These findings have been interpreted as evidence that contextual cues of kinship indirectly influence social ..
  90. ncbi A new lead from genetic studies in depressed siblings: assessing studies of chromosome 3
    Steven P Hamilton
    Department of Psychiatry and Institutefor Human Genetics, University of California, San Francisco, USA
    Am J Psychiatry 168:783-9. 2011
    ..Thus, the significance of this finding remains uncertain, although it points to a gene that might hold significant promise for further developments in studying the pathophysiology and treatment of major depressive disorder...
  91. ncbi The effect of siblings on early development: a potential contributor to personality differences in mammals
    Robyn Hudson
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Distrito Federal, Mexico
    Dev Psychobiol 53:564-74. 2011
  92. ncbi Long-term follow-up of the human phenotype in three siblings with cone dystrophy associated with a homozygous p.G461R mutation of KCNV2
    Christoph Friedburg
    Department of Ophthalmology, Justus Liebig University, Giessen, Germany
    Invest Ophthalmol Vis Sci 52:8621-9. 2011
    To provide an up to 14-year overview of the early ocular phenotype in siblings with a homozygous p.G461R mutation in the KCNV2 gene.
  93. ncbi Familial hyperestrogenism in both sexes: clinical, hormonal, and molecular studies of two siblings
    Regina M Martin
    Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular LIM 42, Divisão de Endocrinologia, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, 01065 970 São Paulo, Brasil
    J Clin Endocrinol Metab 88:3027-34. 2003
    ..Here we studied two adult siblings, born to unrelated parents, who presented clinical and hormonal evidence of estrogen excess...
  94. ncbi Visual attention in autism families: 'unaffected' sibs share atypical frontal activation
    Matthew K Belmonte
    Department of Human Development, Cornell University, Ithaca, NY 14853 4401, USA
    J Child Psychol Psychiatry 51:259-76. 2010
    ..Similar autistic traits in ASC relatives without a diagnosis suggest a continuity between clinically affected and unaffected family members...
  95. ncbi An autistic endophenotype results in complex immune dysfunction in healthy siblings of autistic children
    Marina Saresella
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi ONLUS Foundation IRCCS S M Nascente, Italy
    Biol Psychiatry 66:978-84. 2009
  96. ncbi Siblings' experiences of having a brother or sister with autism and mental retardation: a case study of 14 siblings from five families
    Ylva Benderix
    Department of Health Sciences, Section of Nursing, Lund University, Lund, Sweden
    J Pediatr Nurs 22:410-8. 2007
    The aim of this study was to describe the present and past experiences of 14 siblings from five families in terms of having a brother or sister with autism and mental retardation...
  97. ncbi Triple A syndrome with ophthalmic manifestations in two siblings
    Kalpana Babu
    Vittala International Institute of Ophthalmology, Bangalore, India
    Indian J Ophthalmol 55:304-6. 2007
    ..We report the ophthalmic manifestations in 2 siblings from a consanguineous family with this syndrome...
  98. pmc A randomized trial of generic versus tailored interventions to increase colorectal cancer screening among intermediate risk siblings
    Sharon L Manne
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Behav Med 37:207-17. 2009
    ..Tailored interventions may increase participation in appropriate colorectal cancer screening...
  99. ncbi Fat mass is negatively associated with cortical bone size in young healthy male siblings
    Youri E C Taes
    Department of Endocrinology, Ghent University Hospital, Belgium
    J Clin Endocrinol Metab 94:2325-31. 2009
    ..Whereas lean mass exerts a positive influence on bone size, the relationship between fat and bone remains unclear...
  100. ncbi COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage
    Linda S de Vries
    Department of Neonatology, Wilhelmina Children s Hospital, UMC Utrecht, The Netherlands
    Ann Neurol 65:12-8. 2009
    ..To report the presence of intracerebral hemorrhage and porencephaly, both present at birth, in two preterm infants with a mutation in the collagen 4 A1 gene...
  101. ncbi Wilson disease in septuagenarian siblings: Raising the bar for diagnosis
    Aftab Ala
    Division of Liver Diseases, Recanati Miller Transplant Institute, The Mount Sinai Medical Center, New York, NY, USA
    Hepatology 41:668-70. 2005
    ..We report the clinical features, diagnostic evaluation, and outcome with treatment of two septuagenarian siblings evaluated as part of a research trial for treatment of neurological WD...

Research Grants75

  1. Genome-wide recombination as a risk factor for nondisjunction
    NATASHA D HOLLIS; Fiscal Year: 2010
    ..we will examine inter-individual variation in genome-wide recombination between DS probands and their siblings. We will look at two basic characteristics: (1) the number of genome-wide recombinant events and (2) location of ..
  2. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..TAL (TAL-/-) develop normally, they are 27-fold and 79-fold more likely to develop cirrhosis and HCC than their siblings having normal TAL gene and activity...
  3. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..with a de-methylated promoter develop diabetes, obesity, and, in certain strains, cancer, but their darker siblings with a brown coat color remain healthy...
  4. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..death syndrome (SIDS) and include prematurely born infants, infants with apparent life threatening events (ALTE), siblings of infants with SIDS and typical infants born at term...
  5. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..mice, while Lgr8, Notch1 and Numb mRNA levels were drastically deceased as compared with age-matched wild type siblings. In contrast, the expressions of Esr1 (ER1) and Esr2 (ER2) were significantly elevated...
  6. Interaction of fetal growth and bisphenol A in obesity
    Frederick S vom Saal; Fiscal Year: 2013
    ..We have developed a novel mouse model that results in siblings produced by hemiovariectomized mothers that range from intrauterine growth restricted (IUGR) to macrosomic based ..
  7. Molecular Analysis of Pericentric Sister Chromatid Cohesion
    PAUL CONNOR MEGEE; Fiscal Year: 2013
  8. Identification of Disease-Causing Mutations in SCID Using Exome-Wide Sequencing
    Joseph L Roberts; Fiscal Year: 2010
    ..the SCID patients of unknown etiology by sequencing the exomes of those patients (along with those of unaffected siblings or parents), bioinformatically identifying candidate genes that are bi-alellically inactivated and likely to be ..
  9. Regional Biocontainment Laboratory
    Charles Bailey; Fiscal Year: 2007
    ..The Provost and Chief Financial Officer have committed the University to pay these costs as appropriate should they exceed the balance of the start-up contingency fund. ..
  10. Mother Sibling Interactions
    Julie A Thompson; Fiscal Year: 2010
    ..12-14] However, little research has explored the effects on other members of the family, such as older siblings. The proposed 2-year study will use a longitudinal, comparative, mixed method design to explore the impact of a ..
  11. Fanconi Anemia as a Model for Susceptibility to Human Papillomavirus Infection
    ..of infection with 37 HPV subtypes in individuals with FA and their parents (obligate heterozygotes) and siblings (potential heterozygotes;possible sources of HPV);and 2) characterize the immunological basis (primarily natural ..
  12. Individual Predoctoral Dental Scientist Fellowship
    Angela Gullard; Fiscal Year: 2013
    ..that the transgenic CED mouse model displays abnormal dentin formation as mediated by altered expression of the SIBLINGs, in particular MEPE, caused by the overexpression of mature TGF21...
    ART PETRONIS; Fiscal Year: 2009
    ..second aim is to perform whole DNA methylome studies in peripheral blood samples from pairs of twins and non-twin siblings where only one of the twins or siblings is affected with T1D...
  14. Molecular Pathogenesis of Coenzyme Q10 Deficiency
    Michio Hirano; Fiscal Year: 2012
    ..Last year, we reported the first mutations responsible for primary CoQ10-deficiency;in two siblings with the infantile form of CoQ10 deficiency, we identified a homozygous missense mutation in the COQ2 gene which ..
  15. Newborn screening for identification &prospective followup of infants with SMA
    Kathryn J Swoboda; Fiscal Year: 2013
    ..Preliminary observations from the STOP SMA study, in which younger siblings were identified early in infancy and enrolled in a subspecialty-based medical home with access to proactive care ..
  16. Developmental Genetic Epidemiology of Smoking
    Hermine H Maes; Fiscal Year: 2013
    ..but variance components do not, 3) the influence of parents and parental smoking decreases and that of siblings and peers increases from adolescence to young adulthood, 4) the influence of measured environmental factors ..
  17. Humanization of a mouse anti-OX40 monoclonal antibody to treat cancer
    Andrew D Weinberg; Fiscal Year: 2012
    ..Agonox is proposing to genetically engineer the mouse antibody to become more "human" so that several rounds of treatment may be administered in order to achieve an even better outcome for cancer patients in future clinical trials. ..
  18. Benaroya Research Institute/UCDHSC Autoimmune Cooperative Study Group
    George S Eisenbarth; Fiscal Year: 2011
    ..islet autoimmunity based upon synergy of specific high risk alleles (DR3/4-DQ8) and haplotype sharing with siblings, and defined related but unique risk factors for celiac disease...
  19. Clinical Outcomes for Siblings of Children with Vesico-Ureteral Reflux
    CALEB PENNELL NELSON; Fiscal Year: 2013
    ..In this application, I propose to investigate the clinical dilemma posed by siblings of children with vesicoureteral reflux (VUR)...
  20. Stem Cell Models of Familial Combined Hypolipidemia
    Kiran Musunuru; Fiscal Year: 2013
    ..Recently, we applied exome sequencing to two healthy siblings in a family with an unusual lipid pattern that we have termed "familial combined hypolipidemia"-extremely low low-..
  21. Multigenerational FamIlial and Environmental Risk for Autism (MINERvA) Network
    Abraham Reichenberg; Fiscal Year: 2013
    ..over 20,000 cases of ASD, and family linkages over three generations (grandparents, parents/aunts/uncles, siblings/cousins)...
  22. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
    ..urine samples from children and adolescent patient populations who have been recently diagnosed with T1D, their siblings, and at-risk cohorts from the TrialNet network (
  23. Self-Regulation and Sleep in Children At Risk for Autism Spectrum Disorders
    AMY J SCHWICHTENBERG; Fiscal Year: 2013
    ..It is critically important to study the infant siblings of children with ASD because they are at risk not only for ASD, but also for numerous negative developmental ..
  24. Self-Regulation and Sleep in Children At Risk for Autism Spectrum Disorders
    AMY J SCHWICHTENBERG; Fiscal Year: 2012
    ..It is critically important to study the infant siblings of children with ASD because they are at risk not only for ASD, but also for numerous negative developmental ..
    Siobhan M Dolan; Fiscal Year: 2010
    ..In these families, the possibility exists that the children, grandchildren, siblings and parents of the affected individual may suffer a similar fate...
  26. Homolog orientation and segregation in acentrosomal meiosis
    Kim S McKim; Fiscal Year: 2013
    ..Finally, we will test the hypothesis that the bi-orientation of homologs depends on an interaction between chromosome associated and central spindle microtubules. ..
  27. Use of a Fragile X premutation knock-in mouse to study FXPOI
    Joshua Johnson; Fiscal Year: 2013
    ..a diagnosis of FXPOI, the average age at menopause of all women with the premutation is ~5 yrs earlier than their siblings without the PM...
  28. Aging Together: Brothers and Sisters of the Wisconsin Longitudinal Study
    John Robert Warren; Fiscal Year: 2013
    ..The combined "graduate" and "sibling" data-supplemented with interviews of graduates'and siblings'spouses or widows and a variety of administrative records-form the core of the Wisconsin Longitudinal Study (..
  29. Mineralization of the matrix in disease and health
    PETER S ROWE; Fiscal Year: 2013
    ..Key players in this bone kidney axis are a group of related extracellular matrix proteins (SIBLINGs). These proteins all map to a tightly clustered region on chromosome 4q...
    Lynn Cooley; Fiscal Year: 2009
    ..A phenotype associated with loss of follicle cells ring canals will likely provide the first insight into their function in epithelial cells. ..
  31. Effect of Birth Order and Genetics on Infant Parenting and Obesity Risk
    Ian M Paul; Fiscal Year: 2013
    ..collection occurring as part of INSIGHT, the proposed research adds two major pieces by enrolling second born siblings and collecting genetic specimens from both siblings and their parents...
  32. Prenatal androgen effects on sex-related neural processing of reward and threat
    Sheri A Berenbaum; Fiscal Year: 2013
    ..We will compare 20 women and 20 men with CAH to their same-sex unaffected siblings on magnetic resonance imaging (MRI), behavioral, and self-report measures of reward and emotional memory...
  33. Cell Death and Antibody-Mediated Protection from Autoimmunity
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2010
    ..evaluate the profile of natural and pathologic autoantibody responses in clinical populations, including close siblings and sets of monozygotic and dizygotic twins with lupus and other autoimmune diseases...
  34. Genetics of Parkinsonism in a Special Population of Untreated Schizophrenia
    Gabriel Alejandro De Erausquin; Fiscal Year: 2013
    ..With the funds ofthis award we will focus on the clinical characterization of the probands and their siblings as well as of controls and their siblings to investigate the heritability ofa composite endophenotype including ..
  35. Reducing Obesity in Underserved Postpartum African American Women
    Caroline M Apovian; Fiscal Year: 2010
  36. Small Integrin-binding Glycophosphoproteins as Biomarkers for Prostate Cancer
    Neal S Fedarko; Fiscal Year: 2013
    ..Members of a gene family we have been studying, termed SIBLINGs (for Small Integrin Binding Ligand N-linked Glycoproteins) are normally expressed by bone but are also induced in ..
  37. Identification of XX DSD Mutations by RNA-seq and Comparative Genomics
    Vicki N Meyers-Wallen; Fiscal Year: 2013 identify a causative mutation in the subtype of XX DSD in which XX individuals develop testes while their XX siblings develop ovotestes...
  38. In utero antidepressant exposures and risk for autism
    Roy H Perlis; Fiscal Year: 2013
    ..consistent with twin studies indicating greater concordance for autism among dizygotic twins compared to non-twin siblings, likely pointing to shared in utero risk...
  39. FASEB Summer Research Conference on Osteopontin Biology
    Neal S Fedarko; Fiscal Year: 2010
    ..a family of multifunctional proteins that have been termed Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs)...
  40. Regulation of Sister-Chromatid Cohesion in Drosophila Meiosis
    SHARON ELIZABETH BICKEL; Fiscal Year: 2013
  41. Community Exercise and Metabolic Syndrome in Black Families
    Diane M Becker; Fiscal Year: 2012
    ..Outcomes will include changes in factors that affect cardiovascular risk. Long term-outcomes will be examined at 1 and 2 years. ..
  42. Molecular characterization of novel loci for orofacial clefting using canine mode
    Danika L Bannasch; Fiscal Year: 2013
    ..A short gestational window (63 days), large litters of full siblings and ease of DNA sample collection make the dog a useful model system...
  43. Genetic Predisposition & Prevention of Neural Tube Defects (NTDs)
    MARGARET ELIZABETH contact ROSS; Fiscal Year: 2010
    ..wildtype siblings. In addition, the genetic and metabolic signature identified in Cd non-neural tissues will be compared against ..
  44. Decision Making in Unaffected First-Degree Relatives of Prostate Cancer Patients
    Clement Gwede; Fiscal Year: 2009
    ..We seek to develop a decision aid (educational DVD) to help men with a positive family history of prostate cancer make informed decisions about testing, with the ultimate goal of reducing the burden of prostate cancer. ..
  45. Convergent Genetic and Genomic Analyses of Bipolar Disorder
    Ayman H Fanous; Fiscal Year: 2012
    ..of identifying causative variants, these subjects will come from families in which there are at least 3 affected siblings. We will compare the genome sequences of these subjects to the sequence data in the 1000 Genomes Project, which ..
  46. Occult Small Vessel Cerebrovascular Disease in High Risk Families
    PAUL ALAN NYQUIST; Fiscal Year: 2013
    ..a markedly increased prevalence of silent SVCD (73%) on MRI in a pilot study of 45 apparently healthy middle-aged siblings of probands with known premature coronary artery disease (CAD)...
  47. The health status of Caucasian and African American living with kidney donors
    Sandra J Taler; Fiscal Year: 2010
    ..Comparison controls for the study will be spouses and siblings of each donor and, for a subgroup, community control subjects from the Rochester Epidemiology Project, Olmsted ..
    Linda Van Eldik; Fiscal Year: 2009
    ..aims are:1) to identify and phenotype 300 obese Hispanic probands (ages 4-18 y) and their biological parents and siblings, 2) to construct a 10cM map for 1600 Hispanic individuals to be used in a genome-wide scan for loci that affect ..
  49. Identification of radiation sensitivity alleles by whole exome sequencing
    Patrick Concannon; Fiscal Year: 2012
    ..lines by candidate gene approaches have yielded results that are consistent with this model;we identified two siblings with biallelic LIG4 mutations and a second, as yet unreported, patient with biallelic mutations in RNF168...
  50. iPSC from British and Danish dementias: new discovery tools for brain amyloidoses
    JORGE A GHISO; Fiscal Year: 2013
    ..iPSC lines from dermal fibroblasts obtained from a cohort of FBD and FDD patients as well as from non-carrier siblings of both disorders using repetitive mRNA transfections, a safer non- DNA-integrating technology successfully used ..
  51. The Role of SLITRK1 in Tourette and Related Disorders
    Matthew W State; Fiscal Year: 2010
    ..A non-synonymous substitution at a highly conserved amino acid in the transmembrane domain in 2 affected siblings, not present in 4000 control chromosomes;and 3) in two unrelated individuals, the identical single base ..
  52. Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar Disorder
    David C Glahn; Fiscal Year: 2012
    ..examinations on 130 euthymic patients with BPI (65 with history of psychosis), 130 of their unaffected same-sex siblings and 65 unrelated comparison subjects...
  53. TGF-beta polymorphisms and breast cancer in families
    Boris Pasche; Fiscal Year: 2013
    ..This project will study 65 genes of the TGF-2 pathway in 5357 women with breast cancer and their unaffected sisters and determine which genes are associated with breast cancer risk. ..
  54. 2/2-Preventing Eating Disorders and Reducing Comorbidity
    DENISE ELLA WILFLEY; Fiscal Year: 2010
    ..for an ED: a history of depression and/or exposure to critical comments about weight/eating from teachers/coaches/siblings and/or low-level compensatory behaviors (e.g., vomiting and purging)...
    Arthur Landy; Fiscal Year: 2012
    ..and regulation on the iso-energetic site-specific recombination sponsored by ? Int (and its related siblings) is still not understood...
  56. Children's Responses to Sibling Death in NICU/PICU in 3 Racial/Ethnic Groups
    JoAnne M Youngblut; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Death of a sibling is a double loss for surviving siblings - loss of a playmate, confidante, friend, role model - and loss of parents whose grief leaves them with little to no emotional energy to ..
  57. Quasi-experimental studies of early risk factors for severe psychopathology
    Paul Lichtenstein; Fiscal Year: 2013
    ..In particular, we will compare differentially exposed full siblings, an approach that rules out all genetic factors that could account for the statistical association between early ..
  58. Genome-wide recombination profiles in oocytes with chromosome 21 nondisjunction
    Stephanie L Sherman; Fiscal Year: 2010
    ..of inter-individual variation in recombination among oocytes with nondisjoined chromosomes 21 and their siblings: 1) rate of genome-wide recombination and 2) preferred sites of recombination throughout the genome...
  59. A Longitudinal Study of Adopted Youth and Their Families
    MATTHEW K MCGUE; Fiscal Year: 2013
    ..At intake, each family consisted of pair of adolescent siblings and their rearing parents, a total of 2394 individuals...
    Richard K Olson; Fiscal Year: 2013
    ..listening comprehension (Project V) will be administered to a sample of identical and fraternal twins and their siblings in which at least one member of each twin pair has a reading or writing disability, to an independent sample of ..
  61. Investigating the role of MTBP in aging using a novel mouse model
    Brian C Grieb; Fiscal Year: 2013
    ..Furthermore, siblings of centenarians have a greater chance of becoming centenarians themselves, compared to age-matched controls...
  62. Natural History of Pre-diabetic Autoimmunity (DAISY)
    Marian J Rewers; Fiscal Year: 2010
    ..cohorts of very young children who are at up to 20-fold increased risk of type 1 diabetes: 1) a cohort of 693 siblings and offspring (current median age 4...
    Michael Fried; Fiscal Year: 2002
    ..We propose to study a cohort of hemophilic siblings infected with hepatitis C to define the natural history, immunologic, and genetic factors that influence its ..
  64. A Comparative History of Twentieth-Century Catholic Hospitals
    Barbra Mann Wall; Fiscal Year: 2010
    ..It will provide a complex illustration of what it means for institutions to encounter drastic change and emerge with a new vision and community purpose. ..
  65. Family Decision Making in Pediatric Bone Marrow Transplant
    Rebecca Pentz; Fiscal Year: 2009
    ..It is widely assumed by the transplant community and the courts that donor siblings benefit from transplant...
    GUNHILDE BUCHSBAUM; Fiscal Year: 2003
    ..A matched pair logistic regression will be performed to obtain an adjusted estimate of the impact of familiality and vaginal delivery in UT and POP, taking into account other risk factors. ..
    Jan Loney; Fiscal Year: 1991
    ..In the proposed two-year grant period, data analysis for the 21 to 23 year old samples will be conducted. Analyses that are appropriate for the partial sample of 28 to 32 year old subjects and brothers will also be conducted...
    Phoebe Williams; Fiscal Year: 2000
    Research into the amelioration of mental health problems of siblings of chronically ill/disabled children is essential to control future morbidity...
  69. Genetics of Longevity in Long-Lived Siblings
    Sangkyu Kim; Fiscal Year: 2010
    ..While recruiting the human subjects residing in Louisiana, we encountered rare families in which siblings tend to live exceptionally long...
    Sanford Markowitz; Fiscal Year: 2005
    ..This will be accomplished by identifying and collecting DNA from a cohort of 300 pairs of siblings in which the two members of each sibship have each developed colon neoplasia by age 65 or younger...
  71. 2007 Small Intergin Binding Proteins Gordon Research Conference
    Neal Fedarko; Fiscal Year: 2007
    ..Normally expressed by skeletal tissue, SIBLINGs are thought to play a role in mineralization as well as cellular adhesion and migration...
  72. Coronary Disease Detection by Thalluim SPECT and Fast CT
    Lewis Becker; Fiscal Year: 2006
    ..coronary calcification (ultrafast computed tomography) in a high-risk asymptomatic population of 30-59 year old siblings of people with premature CAD...
  73. Substance Dependent Adolescents: Imaging Risk-Taking
    Thomas J Crowley; Fiscal Year: 2010
    ..We also will examine patients'at-risk 9-11 year-old younger siblings, and control youngsters, before any of the siblings engage in extensive substance use...
  74. Sibling-mediated Social Communicative Intervention for Children with Autism Spect
    LING LING TSAO; Fiscal Year: 2010
    ..Children with autism, however, spend the majority of their time in home and community environments. Siblings in those settings might well be able to support or enhance social communicative development of children with ..
    Diane Becker; Fiscal Year: 2000 usual primary care source) for the management of coronary heart disease risk factors in African American siblings of persons with premature coronary disease...