Genomes and Genes
Summary: An ethnic group with historical ties to the land of ISRAEL and the religion of JUDAISM.
Publications385 found, 100 shown here
- Euthanasia: an overview and the jewish perspectiveBenjamin Gesundheit
Unit of Bone Marrow Transplantation, Cancer Immunotherapy and Immunobiology Research Center, Hadassah Hebrew University Medical Center, Jerusalem
Cancer Invest 24:621-9. 2006..Over the course of history, abuse of the term has led to medical atrocities. Familiarity with the relevant bioethical issues and the development of practical guidelines might improve clinical performance...
- The genome-wide structure of the Jewish peopleDoron M Behar
Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel
Nature 466:238-42. 2010Contemporary Jews comprise an aggregate of ethno-religious communities whose worldwide members identify with each other through various shared religious, historical and cultural traditions...
- The history of African gene flow into Southern Europeans, Levantines, and JewsPriya Moorjani
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 7:e1001373. 2011..For the Jewish admixture, we obtain an average estimated date of about 72 generations. This may reflect descent of these groups from a common ancestral population that already had some African ancestry prior to the Jewish Diasporas...
- Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish populationSteven M Bray
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 107:16222-7. 2010..Eastern origin with other Jewish Diaspora populations, but also suggest that the AJ population, compared with other Jews, has had the most European admixture...
- Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi JewsJudith Aharon-Peretz
Department of Neurology and the Cognitive Neurology Unit, Rambam Medical Center, Haifa, Israel
N Engl J Med 351:1972-7. 2004..We examined whether mutations in the GBA gene are relevant to idiopathic Parkinson's disease...
- Evaluation of 22 genetic variants with Crohn's disease risk in the Ashkenazi Jewish population: a case-control studyInga Peter
Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029 USA
BMC Med Genet 12:63. 2011..We evaluated a set of well-established CD-susceptibility variants to determine if they can explain the increased CD risk in the AJ population...
- Unique lipoprotein phenotype and genotype associated with exceptional longevityNir Barzilai
Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA
JAMA 290:2030-40. 2003..Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility...
- Genomic microsatellites identify shared Jewish ancestry intermediate between Middle Eastern and European populationsNaama M Kopelman
Porter School of Environmental Studies, Department of Zoology, Tel Aviv University, Ramat Aviv, Israel
BMC Genet 10:80. 2009....
- The impact of Converso Jews on the genomes of modern Latin AmericansC Velez
Human Genetics Program, Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA
Hum Genet 131:251-63. 2012..More importantly, they provide a rationale for the occurrence of mutations typically associated with the Jewish Diaspora in Latin American communities...
- Implications for health and disease in the genetic signature of the Ashkenazi Jewish populationSaurav Guha
Department of Psychiatry, Division of Research, The Zucker Hillside Hospital Division of the North Shore Long Island Jewish Health System, 75 59, 263rd St Glen Oaks, NY 11004, USA
Genome Biol 13:R2. 2012..Comparison of the genotyping data with that of neighboring European and Asian populations enabled the Ashkenazi Jewish-specific component of the variance to be characterized with respect to disease-relevant alleles and pathways...
- Jewish medical ethics and end-of-life careBarry M Kinzbrunner
J Palliat Med 7:558-73. 2004..justice, with the major difference between Jewish law and secular medical ethics being that orthodox or traditional Jews are perceived to limit their autonomy by choosing, with the assistance and advice of their rabbis, to follow God's ..
- MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish populationDoron M Behar
Bruce Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
Eur J Hum Genet 12:355-64. 2004..DNA (mtDNA) hypervariable segment 1 (HVS-1) sequence and restriction site polymorphisms in 565 Ashkenazi Jews from different parts of Europe...
- Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R allelesCagdas Tazearslan
Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Aging Cell 10:551-4. 2011..These results demonstrate that the human longevity-associated IGF1R variants are reduced-function mutations, implying that dampening of IGF1 signaling may be a longevity mechanism in humans...
- Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humansO Vahava
Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Science 279:1950-4. 1998..A truncated protein presumably impairs high-affinity binding of this transcription factor in a dominant negative fashion, leading to progressive hearing loss...
- Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish populationSharon Simchoni
Medical Genetics Unit, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem 91031, Israel
Proc Natl Acad Sci U S A 103:3770-4. 2006....
- The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individualsJ P Struewing
Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 11:198-200. 1995..9% of Ashkenazim (95% confidence limit, 0.4-1.8%) and in none of the reference samples. Our results suggest that one in a hundred women of Ashkenazi descent may be at especially high risk of developing breast and/or ovarian cancer...
- Haplotype analysis of BRCA2 8765delAG mutation carriers in French Canadian and Yemenite Jewish hereditary breast cancer familiesA P Manning
McGill University Centre Research Institute, , Canada
Hum Hered 52:116-20. 2001..However, the disease-associated allele of one of the intragenic markers differed between the Yemenite Jews and French Canadian families, indicating that the 8765delAG mutation has independent origins in these two ..
- Multiple origins of Ashkenazi Levites: Y chromosome evidence for both Near Eastern and European ancestriesDoron M Behar
Bruce Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
Am J Hum Genet 73:768-79. 2003....
- The glucocerebrosidase gene and Parkinson's disease in Ashkenazi JewsMichael J Eblan
N Engl J Med 352:728-31; author reply 728-31. 2005
- A genome-wide association study identifies IL23R as an inflammatory bowel disease geneRichard H Duerr
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Science 314:1461-3. 2006..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease...
- The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease: is there a gender effect?A Orr-Urtreger
Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
Neurology 69:1595-602. 2007..The G2019S change in LRRK2 exon 41 has been associated with disease at varying frequencies in Asian, European, North American, and North African populations, and is particularly prevalent among Ashkenazi Jews.
- Carrier screening in individuals of Ashkenazi Jewish descentSusan J Gross
Albert Einstein College of Medicine, Bronx, New York, USA
Genet Med 10:54-6. 2008..It may be prudent, however, to document in the patient's record the rationale for any significant deviation from this guideline...
- Functionally significant insulin-like growth factor I receptor mutations in centenariansYousin Suh
Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 105:3438-42. 2008..Thus, genetic alterations in the human IGF1R that result in altered IGF signaling pathway confer an increase in susceptibility to human longevity, suggesting a role of this pathway in modulation of human lifespan...
- The origin of Eastern European Jews revealed by autosomal, sex chromosomal and mtDNA polymorphismsAvshalom Zoossmann-Diskin
Department of Haematology and Genetic Pathology, School of Medicine, Flinders University, Adelaide, Australia
Biol Direct 5:57. 2010This study aims to establish the likely origin of EEJ (Eastern European Jews) by genetic distance analysis of autosomal markers and haplogroups on the X and Y chromosomes and mtDNA.
- Long-term follow-up of Jewish women with a BRCA1 and BRCA2 mutation who underwent population genetic screeningKelly A Metcalfe
Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada
Breast Cancer Res Treat 133:735-40. 2012..Uptake of either surgery resulted in decreased distress. Provision of population BRCA testing resulted in reduced risks of breast and ovarian cancers in women with a mutation...
- Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2B B Roa
Baylor DNA Diagnostic Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Genet 14:185-7. 1996....
- Offspring of centenarians have a favorable lipid profileN Barzilai
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Am Geriatr Soc 49:76-9. 2001..These data support the notion that a certain phenotypic lipid profile may be transmitted in families and suggest that a favorable lipid profile may play a role in longevity...
- Mitochondrial myopathy, sideroblastic anemia, and lactic acidosis: an autosomal recessive syndrome in Persian Jews caused by a mutation in the PUS1 geneAvraham Zeharia
Department of Pediatircs, Schneider Children s Medical of Israel, Petah Tiqva
J Child Neurol 20:449-52. 2005..mitochondrial myopathy, lactic acidosis, and sideroblastic anemia The patient, a product of consanguineous Persian Jews, had the association of mental retardation, dysmorphic features, lactic acidosis, myopathy, and sideroblastic ..
- Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in womenSagiv Shifman
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
PLoS Genet 4:e28. 2008..58 (p = 8.8 x 10(-7); p = 1.6 x 10(-5) for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease...
- The case of Samuel Golubchuk and the right to liveAlan Jotkowitz
Ben Gurion University of the Negev, Beer Sheva, Israel
Am J Bioeth 10:50-3. 2010..3. In modern society there exists an erosion of a basic attitude towards the value of life. 4. The ability of physicians to predict life expectancy in terminally ill patients has been shown repeatedly to be quite limited...
- Dysferlinopathy in the Jews of the Caucasus: a frequent mutation in the dysferlin geneE Leshinsky-Silver
Molecular Genetics Laboratory, Wolfson Medical Center, Holon, Israel
Neuromuscul Disord 17:950-4. 2007..We report another cluster of this muscular dystrophy in Israel among Jews of the Caucasus region...
- Genetic variants in IL-23R and ATG16L1 independently predispose to increased susceptibility to Crohn's disease in a Canadian populationWilliam G Newman
Academic Department of Medical Genetics, University of Manchester, Manchester, UK
J Clin Gastroenterol 43:444-7. 2009..To establish the relevance of variants in the IL-23R and ATG16L1 genes in inflammatory bowel disease (IBD)...
- Type III 3-methylglutaconic aciduria (optic atrophy plus syndrome, or Costeff optic atrophy syndrome): identification of the OPA3 gene and its founder mutation in Iraqi JewsY Anikster
Section on Human Biochemical Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Am J Hum Genet 69:1218-24. 2001..Milder mutations in OPA3 should be sought in patients with optic atrophy with later onset, even in the absence of additional neurological abnormalities...
- Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B geneDimitrios Avramopoulos
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
Genet Med 9:745-51. 2007..This study is a second stage follow-up focusing on regions that showed positive linkage scores in our previous scan but were not fine-mapped at that time...
- The 6q22.33 locus and breast cancer susceptibilityTomas Kirchhoff
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Cancer Epidemiol Biomarkers Prev 18:2468-75. 2009..Further functional studies of candidate genes are in progress, and a large replication analysis is being completed as part of an international consortium...
- Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer riskVirginia G Kaklamani
Cancer Genetics Program, Division of Hematology and Oncology, Department of Medicine and Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
JAMA 300:1523-31. 2008..While there is evidence of an association between circulating adiponectin levels and colorectal cancer risk, no association between genes of the adiponectin pathway and colorectal cancer have been reported to date...
- Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypesM F Hammer
Laboratory of Molecular Systematics and Evolution, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 97:6769-74. 2000....
- Trajectories of resilience, resistance, and distress during ongoing terrorism: the case of Jews and Arabs in IsraelStevan E Hobfoll
Department of Behavioral Sciences, Rush Medical College, 1653 West Congress Parkway, Chicago, IL 60612 3244, USA
J Consult Clin Psychol 77:138-48. 2009..The authors interviewed a nationally representative sample of Jews and Arabs in Israel (N = 709) at 2 times during a period of terrorist and rocket attacks (2004-2005)...
- Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer familiesE Levy-Lahad
Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
Am J Hum Genet 60:1059-67. 1997Germ-line BRCA1 and BRCA2 mutations account for most of familial breast-ovarian cancer. In Ashkenazi Jews, there is a high population frequency (approximately 2%) of three founder mutations: BRCA1 185delAG, BRCA1 5382insC, and BRCA2 ..
- Discerning the ancestry of European Americans in genetic association studiesAlkes L Price
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 4:e236. 2008..We demonstrate that this panel of markers can be used to correct for stratification in association studies that do not generate dense genotype data...
- Associations of high-grade prostate cancer with BRCA1 and BRCA2 founder mutationsIlir Agalliu
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Clin Cancer Res 15:1112-20. 2009..However, there is still uncertainty about the magnitude of association particularly with Gleason score, and family history of prostate, breast, and ovary cancers...
- Deafness genes in Israel: implications for diagnostics in the clinicZippora Brownstein
Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978 Israel
Pediatr Res 66:128-34. 2009..In the future, the identification of specific mutations may be relevant for specific types of treatment...
- A missense mutation in DHDDS, encoding dehydrodolichyl diphosphate synthase, is associated with autosomal-recessive retinitis pigmentosa in Ashkenazi JewsLina Zelinger
Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Am J Hum Genet 88:207-15. 2011..Our results support a pivotal role of DHDDS in retinal function and may allow for new therapeutic interventions for RP...
- Hermansky-Pudlak syndrome type 3 in Ashkenazi Jews and other non-Puerto Rican patients with hypopigmentation and platelet storage-pool deficiencyM Huizing
Section on Human Biochemical Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Am J Hum Genet 69:1022-32. 2001..Five are Ashkenazi Jews; three of these are homozygous for a 1303+1G-->A splice-site mutation that causes skipping of exon 5, deleting ..
- The APCI1307K allele and breast cancer riskM Redston
Nat Genet 20:13-4. 1998
- Oculopharyngeal MD among Bukhara Jews is due to a founder (GCG)9 mutation in the PABP2 geneS C Blumen
Department of Neurology, Hillel Yaffe Medical Center, Hadera, Israel
Neurology 55:1267-70. 2000To determine whether all cases of oculopharyngeal muscular dystrophy (OPMD) among Bukhara Jews share the same founder mutation.
- The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the generality of U.S. population dataA Y Bahar
Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, New South Wales, Australia
Cancer 92:440-5. 2001Several studies have shown that Ashkenazi Jews in the United States and Israel have a high prevalence of the founder mutations BRCA1 185delAG, BRCA1 5382insC, BRCA2 6174delT, and APC I1307K at frequencies of 1.0--1.1%, 0.2--0.3%, 0.6--1...
- The characterization of somatic APC mutations in colonic adenomas and carcinomas in Ashkenazi Jews with the APC I1307K variant using linkage disequilibriumN Peter Zauber
Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ, USA
J Pathol 199:146-51. 2003....
- Y chromosome evidence for a founder effect in Ashkenazi JewsAlmut Nebel
MRC NHLS Wits Human Genomic Diversity and Disease Research Unit, Division of Human Genetics, School of Pathology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa
Eur J Hum Genet 13:388-91. 2005Recent genetic studies, based on Y chromosome polymorphic markers, showed that Ashkenazi Jews are more closely related to other Jewish and Middle Eastern groups than to their host populations in Europe...
- Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish populationS K Hansen
Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, Gentofte, 2820, Copenhagen, Denmark
Diabetologia 48:452-8. 2005....
- The Tyr978X BRCA1 mutation: occurrence in non-Jewish Iranians and haplotype in French-Canadian and non-Ashkenazi JewsLluis Quintana-Murci
Laboratoire de Reproduction, Fertilite et Populations, Institut Pasteur, Paris, France
Fam Cancer 4:85-8. 2005..The same mutation was also reported in non-Jewish high-risk women from Canada. Its occurrence in non-Jewish individuals from Iran has never been tested...
- Trends in incidence of colorectal cancer in Jewish and Arab populations in central IsraelZvi Fireman
Gastroenterology Department, Hillel Yaffe Medical Center, Hadera, Israel
Digestion 72:223-7. 2005To compare the current differences with our earlier findings on the incidence and locations of colorectal cancer (CRC) among Israeli-born Jews and Arabs living within the same central coastal region in Israel.
- LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi JewsLaurie J Ozelius
N Engl J Med 354:424-5. 2006
- Technical standards and guidelines for reproductive screening in the Ashkenazi Jewish populationKristin G Monaghan
Department of Medical Genetics, Henry Ford Hospital, Detroit, Michigan, USA
Genet Med 10:57-72. 2008..They also are advised to take notice of the date any particular standard or guidelines was adopted, and to consider other relevant medical and scientific information that becomes available after that date...
- Type 2 diabetes susceptibility loci in the Ashkenazi Jewish populationMichal Bronstein
Department of Genetics, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
Hum Genet 124:101-4. 2008..Our study, however, strongly supports the robustness of WGA studies for the identification of genes affecting complex traits in general and T2D in particular...
- Mitochondrial DNA control region variation in Ashkenazi Jews from HungaryAnita Brandstätter
Institute of Legal Medicine, Innsbruck Medical University, Innsbruck, Austria
Forensic Sci Int Genet 2:e4-6. 2008..three entire mtDNA control region sequences were generated and analyzed in a population sample from Ashkenazi Jews living in Hungary. The control region was amplified in one piece and sequenced with different sequencing primers...
- Dynamic modification strategy of the Israeli carrier screening protocol: inclusion of the Oriental Jewish Group to the cystic fibrosis panelOrit Reish
Genetics Institute, Assaf Harofeh Medical Center, Zerifin, Israel
Genet Med 11:101-3. 2009..A retrospective population study was conducted to determine the carrier frequencies of recently identified mutations in Oriental Jewish cystic fibrosis patients...
- Type 2 Gaucher disease occurs in Ashkenazi Jews but is surprisingly rareShraga Aviner
Department of Pediatrics, Barzilai Medical Center, Ashkelon, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Blood Cells Mol Dis 43:294-7. 2009..Phenotypically, GD2 in Ashkenazi Jews does not differ significantly from this form in other ethnic groups...
- The development of social essentialism: the case of israeli children's inferences about jews and arabsDana Birnbaum
Department of Psychology, Bar Ilan University, Ramat Gan 52900, Israel
Child Dev 81:757-77. 2010..of various social categories among 144 kindergarten, 2nd-, and 6th-grade Israeli children from 3 sectors: secular Jews, religious Jews, and Muslim Arabs...
- The impact of prenatal diagnosis and termination of pregnancy on the relative incidence of malformations at birth among Jews and Muslim Arabs in IsraelJoel Zlotogora
Ministry of Health, Jerusalem, Israel
Isr Med Assoc J 12:539-42. 2010..As a result, in many cases the incidence of malformations at birth does not represent their true incidence...
- High group A streptococcal carriage in the Orthodox Jewish community of north HackneyJ Spitzer
Departmental of Environmental and Preventive Medicine, St Bartholomew s and the London School of Medicine and Dentistry, Queen Mary, University of London
Br J Gen Pract 51:101-5. 2001....
- Kaposi's sarcoma-associated herpesvirus infection in elderly Jews and non-Jews from New York CityEric A Engels
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
Int J Epidemiol 31:946-50. 2002Worldwide, Kaposi's sarcoma (KS) occurs in immunocompetent elderly adults, especially men. Elderly Jews have relatively high KS risk, but it is unclear whether this indicates heightened prevalence of KS-associated herpesvirus (KSHV), the ..
- A mutation of PCDH15 among Ashkenazi Jews with the type 1 Usher syndromeTamar Ben-Yosef
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
N Engl J Med 348:1664-70. 2003
- NOD2/CARD15 genotype and phenotype differences between Ashkenazi and Sephardic Jews with Crohn's diseaseAmir Karban
Department of Gastroenterology, Rambam Medical Center, Haifa, Israel
Am J Gastroenterol 99:1134-40. 2004..The incidence and prevalence rate of inflammatory bowel diseases is two- to four-fold higher in Ashkenazi Jews as compared to non-Jewish Caucasians...
- Fanconi anemia in Ashkenazi JewsDavid I Kutler
Department of Otolaryngology, New York University Medical Center, New York, USA
Fam Cancer 3:241-8. 2004..6174delT in FANCD1/BRCA2 are also unique to the Ashkenazi Jewish population. Therefore, the study of Fanconi anemia can lend insight into the types of cancer-predisposing genetic diseases specific to the Ashkenazi...
- Educational inequalities in mortality among Israeli Jews: changes over time in a dynamic populationDena H Jaffe
Braun School of Public Health and Community Medicine, Hebrew University Hadassah, Jerusalem, Israel
Health Place 14:287-98. 2008..The observed decreasing mortality rates, indicative of a healthier society, alongside widening educational inequalities in mortality indicates uneven changes within the population...
- The mental health impact of terrorism in Israel: a repeat cross-sectional study of Arabs and JewsM Gelkopf
Department of Community Mental Health, Faculty of Social Health Sciences, University of Haifa, Haifa, Israel
Acta Psychiatr Scand 117:369-80. 2008..Since September 2000 Israeli society has been subjected to numerous deadly terror attacks. Few studies have studied the comparative mental health vulnerability of minorities and majorities to continuous terror attacks...
- Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanomaPhuong L Mai
Clinical Genetic Branch, National Cancer Institute, Rockville, Maryland, United States of America
PLoS ONE 4:e4812. 2009..Further, possible effect of BRCA mutations on non-cancer mortality risk has not been examined...
- Persistent high rates of smoking among Israeli Arab males with concomitant decrease among JewsOrna Baron-Epel
School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel
Isr Med Assoc J 12:732-7. 2010..During the last few decades much effort has been invested into lowering smoking rates due to its heavy burden on the population's health and on costs for the health care services...
- Genetic architecture of prostate cancer in the Ashkenazi Jewish populationJ Vijai
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Br J Cancer 105:864-9. 2011..No study has yet investigated whether these single nucleotide polymorphisms (SNPs) are associated with prostate cancer in the Ashkenazi Jewish (AJ) population...
- A common mutation in the FACC gene causes Fanconi anaemia in Ashkenazi JewsM A Whitney
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201
Nat Genet 4:202-5. 1993..Three additional Jewish patients bearing this allele were found upon screening 21 other families. We conclude that a common mutation in FACC accounts for the majority of Fanconi anaemia in Ashkenazi-Jewish families...
- Molecular basis of heat labile hexosaminidase B among Jews and ArabsG Narkis
Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel
Hum Mutat 10:424-9. 1997..A novel heat labile mutation, previously concluded to exist in the HEXB gene, was identified among Jews and Arabs as 1627 G-->A...
- Variation at NOD2/CARD15 in familial and sporadic cases of Crohn's disease in the Ashkenazi Jewish populationZhifeng Zhou
Division of Molecular Medicine, Department of Medicine, North Shore University Hospital New York University School of Medicine, Manhasset 11030, USA
Am J Gastroenterol 97:3095-101. 2002..The aim of this study was to determine the frequency of these NOD2/CARD15 variants in familial and sporadic CD patients in the Ashkenazi population and to determine their effects on disease susceptibility and age of disease onset (AOO)...
- Obesity among Arabs and Jews in Israel: a population-based studyOfra Kalter-Leibovici
Unit of Cardiovascular Epidemiology, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel
Isr Med Assoc J 9:525-30. 2007..Arabs in Israel have high morbidity and mortality from diabetes and cardiovascular disease. Obesity is a risk factor for both conditions...
- Paranoia and conspiracy thinking of Jews, Arabs, Germans, and Russians in a Polish sampleMonika Grzesiak-Feldman
Faculty of Psychology, University of Warsaw, Warsaw, Poland
Psychol Rep 102:884-6. 2008The study examined the relationship between paranoia and conspiracy thinking of Jews, Arabs, Germans, and Russians among 50 university student volunteers using Fenigstein and Vanable's Paranoia Scale for nonclinical populations and the ..
- Religious coping among Jews: development and initial validation of the JCOPEDavid H Rosmarin
Department of Psychology, Bowling Green State University, Bowling Green, OH 43403, USA
J Clin Psychol 65:670-83. 2009..Results suggest that the JCOPE has good psychometric properties, and that religious coping is a significant predictor of psychological distress among Jews.
- Identification of population substructure among Jews using STR markers and dependence on reference populations includedJennifer B Listman
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
BMC Genet 11:48. 2010..step in understanding population structure to conduct valid association studies of health behaviors among Israeli Jews, we investigated genetic signatures of this history and quantified substructure to facilitate future investigations ..
- Health and religiosity among Israeli JewsAmir Shmueli
The Hebrew University School of Public Health, Department of Health Management, Jerusalem, Israel
Eur J Public Health 17:104-11. 2007The objective of this paper is to explore the connection between self-reported health and religiosity among Israeli Jews, using several self-reported health measures.
- Ashkenazi Jewish screening in the twenty-first centurySusan Klugman
Obstetrics and Gynecology and Women s Health, Albert Einstein, College of Medicine, Bronx, NY, USA
Obstet Gynecol Clin North Am 37:37-46. 2010..Thus, we need to continue to be cognizant of informed consent, test sensitivity, confidentiality, prenatal diagnosis, preimplantation genetic screening, and public health concerns regarding testing...
- Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in IsraelB Davidovici
Epidemiology Department, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva, Israel
J Natl Cancer Inst 93:194-202. 2001BACKGROUND: The incidence of classic Kaposi's sarcoma among Jews in Israel is among the highest in the developed world. Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) is causally linked to Kaposi's sarcoma...
- Tay-Sachs disease in Moroccan Jews: deletion of a phenylalanine in the alpha-subunit of beta-hexosaminidaseR Navon
Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
Am J Hum Genet 48:412-9. 1991..We have found that the mutations underlying Tay-Sachs disease in Ashkenazi and Moroccan Jews are different...
- Factor XI deficiency in Ashkenazi Jews in IsraelR Asakai
Department of Biochemistry, University of Washington, Seattle 98195
N Engl J Med 325:153-8. 1991Severe factor XI deficiency, which is relatively common among Ashkenazi Jews, is associated with injury-related bleeding of considerable severity...
- The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer: clinical and pathologic featuresGershon Y Locker
Evanston Northwestern Healthcare, Feinberg School of Medicine, Northwestern University, 2650 Ridge Ave, Evanston, IL 60201, USA
Cancer Genet Cytogenet 169:33-8. 2006Colorectal cancer is common in Ashkenazi Jews. The I1307K APC mutation occurs in 6-7% of Ashkenazi Jews and increases the risk of colorectal cancer...
- TNFSF15 is an ethnic-specific IBD geneYoana Picornell
Medical Genetics Institute, Cedars Sinai Medical Center Los Angeles, California, USA
Inflamm Bowel Dis 13:1333-8. 2007..The aim was to confirm the association between TNFSF15 high- and low-risk haplotypes and IBD in a Caucasian population...
- Prevalence of beta-thalassemia trait and glucose-6-phosphate dehydrogenase deficiency in Iranian JewsMehran Karimi
Homeostasis and Thrombosis Unit, Hematology Research Center, Shiraz University of Medical Science, Shiraz, Iran
Arch Med Res 39:212-4. 2008..The goal of this study was to compare the frequency of beta-thalassemia trait and G6PD among the Moslem and Jewish populations in Shiraz, southern Iran...
- Four USH2A founder mutations underlie the majority of Usher syndrome type 2 cases among non-Ashkenazi JewsNoa Auslender
Department of Genetics and The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Genet Test 12:289-94. 2008..The aim of the current work was to investigate the genetic basis for USH2 among Jews of various origins. We found that four USH2A mutations (c.239-240insGTAC, c.1000C>T, c.2209C>T, and c...
- Skoura - a genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 geneC Suriu
Institute of Human Genetics, Western Galilee Hospital Nahariya, Israel
Clin Genet 75:230-6. 2009..Genetic screening for the causative mutation among 300 unrelated Moroccan Jews did not reveal carriers for the causative mutation, thus excluding high risk for CIPA in this ethnic subpopulation.
- Cost-effectiveness of population-based BRCA1/2 testing and ovarian cancer prevention for Ashkenazi Jews: a call for dialogueWendy S Rubinstein
NorthShore University HealthSystem Center for Medical Genetics, Northwestern University Feinberg School of Medicine, 1000 Central Street, Suite 620, Evanston, IL 60201, USA
Genet Med 11:629-39. 2009..Cost-effectiveness and gains in life expectancy are important factors in evaluating the desirability of population-based genetic screening, currently the only viable strategy to identify carriers with unrevealing family histories...
- Fine-mapping of candidate region in Amish and Ashkenazi families confirms linkage of refractive error to a QTL on 1p34-p36Robert Wojciechowski
Inherited Disease Research Branch, National Human Genome Research Institute, 333 Cassell Drive, Baltimore, MD 21224, USA
Mol Vis 15:1398-406. 2009..1. We carried out a fine-mapping study of this region in Orthodox Ashkenazi Jewish (ASHK) and Old Order Amish (OOA) families to confirm linkage and narrow the candidate region...
- An ancient autosomal haplotype bearing a rare achromatopsia-causing founder mutation is shared among Arab Muslims and Oriental JewsLina Zelinger
Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Hum Genet 128:261-7. 2010..The data present here demonstrate a large (11 Mbp) genomic region that is likely to originate from an ancient common ancestor of Middle-Eastern Arab Muslims and Jews who lived approximately 5,000 years ago.
- A genetic profile of contemporary Jewish populationsH Ostrer
Human Genetics Program, New York University School of Medicine, MSB 136, New York, New York 10016, USA
Nat Rev Genet 2:891-8. 2001The Jews are an ancient people with a history spanning several millennia...
- Carrier screening for Gaucher disease: lessons for low-penetrance, treatable diseasesShachar Zuckerman
Hebrew University Hadassah Medical School, Jerusalem, Israel
JAMA 298:1281-90. 2007..Gaucher disease (GD) is an autosomal recessive storage disorder, relatively frequent in Ashkenazi Jews. Carrier screening for GD is controversial because common type 1 GD is often asymptomatic and effective treatment ..
- A common founder mutation of CERKL underlies autosomal recessive retinal degeneration with early macular involvement among Yemenite JewsNoa Auslender
Department of Genetics, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Invest Ophthalmol Vis Sci 48:5431-8. 2007..To investigate the genetic basis and clinical manifestations of a characteristic form of retinal degeneration in the Yemenite Jewish population...
- Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob diseaseR Gabizon
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel
Philos Trans R Soc Lond B Biol Sci 343:385-90. 1994..Among Libyan Jews, CJD is a familial disease with an incidence about 100 times higher than the worldwide population...
- Frameshift and splice-junction mutations in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis in Jews or Moroccan originE Leitersdorf
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
J Clin Invest 91:2488-96. 1993..A relatively high prevalence of the disease has been noted in Jews originating from Morocco...
- Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi JewsA Nestorowicz
Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
Hum Mol Genet 5:1813-22. 1996..To define the molecular genetic basis of HI in Ashkenazi Jews, 25 probands were screened for mutations in the sulfonylurea receptor (SUR1) gene by single-strand conformation ..
- Mutations in the connexin 26 gene (GJB2) among Ashkenazi Jews with nonsyndromic recessive deafnessR J Morell
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
N Engl J Med 339:1500-5. 1998..We assessed the contribution of mutations in GJB2 to the prevalence of the condition among Ashkenazi Jews.
- Distinctive genetic signatures in the Libyan JewsN A Rosenberg
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 98:858-63. 2001..Our methods also identified evidence of some similarity between Ethiopian and Yemenite Jews, reflecting possible migration in the Red Sea region...
- Improved survival in women with BRCA-associated ovarian carcinomaIlana Cass
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars Sinai Medical Center and University of California Los Angeles School of Medicine, Los Angeles, California 90048, USAA
Cancer 97:2187-95. 2003..The objective of this study was to determine the clinical characteristics, treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with hereditary ovarian carcinoma...
- The impact of congenital malformations and Mendelian diseases on infant mortality in IsraelJoel Zlotogora
Public Health Services, Ministry of Health, Tel Hashomer, Israel
Isr Med Assoc J 5:416-8. 2003Infant mortality in Israel is twofold higher among non-Jews than Jews.
- Screening for familial dysautonomia in Israel: evidence for higher carrier rate among Polish Ashkenazi JewsOfer Lehavi
Prenatal Diagnosis Division, Genetic Institute and Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Israel
Genet Test 7:139-42. 2003..Although extremely rare in most populations, FD is common among Ashkenazi Jews (AJ), with a calculated carrier frequency of 1 in 30, based on disease prevalence...
- Rachel Saunders-Pullman; Fiscal Year: 2015..The G2019S mutation accounts for up to 20% of PD in Ashkenazi Jews, and LRRK2 is considered a druggable target, making LRRK2 PD an important disease in its own right...
- Moien Kanaan; Fiscal Year: 2015..technologies will be used to identify mutations in the deaf population of the Middle East, including 270 Israeli Jews and 212 Palestinian Arabs. We will explore the physiological processes underlying deafness using mouse mutants...
- Beyond single-point GWAS: genetics of Crohn's disease in Ashkenazi JewsJudy H Cho; Fiscal Year: 2010..non-Jewish European ancestry GWAS do not account for the higher disease prevalence observed among Ashkenazi Jews, suggesting that alternative methodologic approaches should be attempted, which forms the basis of this challenge ..
- SAMANTHA ACSON STREICHER; Fiscal Year: 2015DESCRIPTION (provided by applicant): Epidemiologic studies have consistently found Jews to be at increased risk of pancreatic cancer compared to non-Jewish whites...
- GENETIC PREDISPOSITION TESTING IN COLORECTAL CANCERDeborah Schrag; Fiscal Year: 2003..germline mutation in codon I1307K of the APC gene that appears to increase colorectal cancer risk among Ashkenazi Jews underscores the need to critically evaluate when and how genetic testing strategies should be incorporated into ..
- IMMIGRANTS AND THEIR TRANSITION TO A NEW LABOR MARKETZVI ECKSTEIN; Fiscal Year: 1999DESCRIPTION: More than 600,000 Jews migrated from the Soviet Union to Israel between 1990 and 1994, and during the first two years the immigrants caused an increase of more that 10 percent in the Israeli labor force...
- HIV & STD Risks in Tele Aviv Commercial Sex WorksJonathan Zenilman; Fiscal Year: 2004..and IDU transmission among native Israeli men, and by a heterosexually transmitted epidemic among Ethiopian Jews who immigrated in the 1990s. In the past 3 years, bacterial STD rates have increased substantially...
- Elad Ziv; Fiscal Year: 2014..Since Ashkenazi Jews are a founder population genetic mapping in this population may have several advantages...
- Rapid Cystic Fibrosis DNA Mutation Screening TestWlodek Mandecki; Fiscal Year: 2003..Present genetic screening assays are best suited for detecting CF in Caucasians and Ashkenazi Jews but, the mutations currently assayed for in the CF screening does not detect mutations specific for Black Americans ..
- HOSPITALIZED MENTAL DISORDER IN QUEBEC & ISRAELJean Claude Lasry; Fiscal Year: 1980..of schizophrenia; (3) the suggested differences in rates of affective psychosis between Ashkenazic and Sephardic Jews. As well, results reported frequently in the United States will be replicated in these two foreign settings, and ..
- HUMAN LYSOSOMAL GLUCOCEREBROSIDASEJohn Barranger; Fiscal Year: 1999..Gaucher disease is the most common of the lysosomal storage disorders and is a significant genetic risk for Ashkenazi Jews. The long range goals of the project are to improve the diagnosis and treatment of this group of related disorders...
- SUSCEPTIBILITY GENES FOR HUMAN COLON NEOPLASIASanford Markowitz; Fiscal Year: 2005..illustrative, example of one such colon neoplasia susceptibility variant is the finding that 6 percent of Ashkenazi Jews carry the I1307K APC variant whose DNA sequence is predisposed to in adult life undergo second hit somatic ..
- Longevity Genes in Founder PopulationsALAN SHULDINER; Fiscal Year: 2005..studying the "oldest old' and their offspring in two unique founder populations, the Old Order Amish and Ashkenazi Jews. These populations are ideal for these studies because they are relatively genetically homogeneous founder ..
- CLINICAL TRIAL OF GENE THERAPY FOR GAUCHER DISEASEJohn Barranger; Fiscal Year: 1999..C. 184.108.40.206). Type 1 disease commonly among Ashkenazi Jews where it is the most prevalent inherited disorder, and accounts for 90% of clinical cases...
- Neuroimaging of Genetically-Defined Incipient CJDIsak Prohovnik; Fiscal Year: 2007..We plan to capitalize on a singular cluster of high incidence occurring among Libyan Jews living in Israel, caused by familial transmission of a mutated prion protein (PrP) gene...
- REFUGEES, TRAUMA AND COPINGAllen Glicksman; Fiscal Year: 2000..A matched sample of older American Jews who did not experience the Holocaust were also interviewed...
- A PILOT STUDY OF NEUROCYSTICERCOSIS TREATMENTWILLARD HAUSER; Fiscal Year: 2002..An outbreak of cysticercosis among orthodox Jews living in New York City was reported after food was contaminated with T...
- A Genome Wide SNP Association Study: SchizophreniaAnn Pulver; Fiscal Year: 2007..Case-control and linkage disequilibrium studies in a unique genetically homogeneous community (Ashkenazi Jews) will be conducted using state-of-the-art high throughput, robust, and cost-efficient SNP BeadArray technology ..
- CENTENARIAN STUDIES NETWORKThomas Perls; Fiscal Year: 1999..and genetic data and material "banks" for approximately one thousand centenarians, are as follow: (1) the Ashkenazi Jews study (n=200) in New York and Israel representing a well-established founder population; (2) the Japanese Americans ..
- The Lindex Study: An Ethnic DatabaseJACOB LINDENTHAL; Fiscal Year: 2003..launch an existing interactive database on the internet dealing with published studies of diseases experienced by Jews of North America during the years 1874 through 2000 The database, known as the Lindex, consists presently of 2050 ..
- BEYOND STIGMA--INTERPRETING GENETIC DIFFERENCEPamela Sankar; Fiscal Year: 2003..The recent experience of Ashkenazic Jews and BRCA1/2 testing and community complaints about stigmatization, gives substance to these concerns...
- Genetics and Historical Demography of the AshkenazimDaniel Garrigan; Fiscal Year: 2005..explanations for why there is such a high prevalence of mutations that cause disease phenotypes among the Ashkenazi Jews. The approach integrates a theoretical and empirical approach...
- HETEROGENEITY OF SCHIZOPHRENIAAnn Pulver; Fiscal Year: 2001..studies using highly polymorphic microsatellite markers in a unique genetically homogeneous community (Ashkenazi Jews) will be conducted...
- GENETIC STUDIES IN INFLAMMATORY BOWEL DISEASEJUDY CHO; Fiscal Year: 2002..disease include the overlap between Crohn's disease and ulcerative colitis and its high prevalence in Ashkenazi Jews. Data on putative loci on chromosomes 16 and 12 are provided...
- PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATIONHenry Lynch; Fiscal Year: 2004..The I1307K mutation has been identified in approximately 6 percent of Ashkenazi Jews, approximately 10 percent of Ashkenazim with CRC, and approximately 28 percent of Ashkenazim who have both CRC and ..
- Beta-glucocerebrosidase Mutations and PD in the AshkenazimLorraine Clark; Fiscal Year: 2006..In this proposal we will focus on Ashkenazi Jews (AJ), a genetically isolated population...
- Alcohol in Israel: Genetic and Environmental EffectsDeborah Hasin; Fiscal Year: 2007..Elevated ADH2*2 prevalence in Jews facilitates its study in Jewish samples...
- Phenylalanine Hydroxylase Deficiency: Response to BH4Reuben Matalon; Fiscal Year: 2002..Treatment with BH4 should lead to a better outcome for PKU patients and for maternal PKU. ..
- Telephone-Based Genetic Counseling: An Equivalence TrialMarc Schwartz; Fiscal Year: 2008..abstract_text> ..
- MA Admixture Mapping Development & Application to NIDDMMichael Seldin; Fiscal Year: 2008..Finally, the three strongest signals will be further investigated utilizing a dense set of SNPs in the putative susceptibility regions. [unreadable] [unreadable]..
- RESPONSE OF PHENYLKETONURIA TO TETRAHYDROBIOPTERIN (BH4)Reuben Matalon; Fiscal Year: 2007..Abstract Not Provided ..
- Decisions & Outcomes of BRCA1/2 Test for Breast PatientsMarc Schwartz; Fiscal Year: 2008..UC on quality of life and psychosocial well-being; 3) To identify baseline factors that predict who is most and least likely to benefit from RGC; and 4) to evaluate the cost effectiveness of the RGC intervention. ..
- Deborah S Hasin; Fiscal Year: 2016..abstract_text> ..
- FAMILIAL COLORECTAL NEOPLASIA COLLABORATIVE GROUPNoralane Lindor; Fiscal Year: 2007..fs20\par \par } ..
- Admixture Mapping Development and Testing in AA SLEMichael Seldin; Fiscal Year: 2009..abstract_text> ..
- DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGINGNir Barzilai; Fiscal Year: 2009..abstract_text> ..
- Reducing Unsafe Drinking in HIV Primary CareDeborah Hasin; Fiscal Year: 2009..abstract_text> ..
- Terrorism and Traumatic Responding: Exposure and Resiliency FactorsSTEVAN HOBFOLL; Fiscal Year: 2009..In Study 2, we will survey 1,000 individual Jews and Arabs every three-months for 24 months (i.e., n=8,000), with complete replacement (i.e...
- INTERNET INTERVENTION FOR BRCA1/BRCA2 UNINFORMATIVESMarc D Schwartz; Fiscal Year: 2010....
- FORMATION AND SURVIVAL OF RED BLOOD CELLSErnest Beutler; Fiscal Year: 2001..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
- PRISM--COMORBIDITY DIAGNOSIS FOR DRUG ABUSE TREATMENTDeborah Hasin; Fiscal Year: 2001..The study results will provide empirical evidence that is likely to be useful in formulating DSM-V. ..
- INTERACTIVE DECISION AID FOR BRCA 1/2 MUTATION CARRIERSMarc Schwartz; Fiscal Year: 2003..If effective, the IDA can easily be disseminated to BRCA1/2 carriers across the country and adapted for use with other populations with inherited risk for cancer. ..
- A Mouse Model of Gaucher DiseaseErnest Beutler; Fiscal Year: 2005..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
- EPIDEMIOLOGIC STUDIES OF ALCOHOL USE DISORDERSDeborah Hasin; Fiscal Year: 2002..If received, the ISA will enable Dr. Hasin to focus on her research, on developing new skills and knowledge, and contributing to an understanding of alcohol use disorders. ..
- Relationship between Bio and Psych Correlates of PTSDRachel Yehuda; Fiscal Year: 2005..abstract_text> ..
- KNOCKOUT MODEL FOR CANAVAN DISEASEReuben Matalon; Fiscal Year: 2001..5) The knock-out mouse will be used in future studies for determining the metabolic role of NAA in brain, for experimentation with enzyme therapy and gene therapy. ..
- Psychobiology of PTSD: A Decade of ProgressRachel Yehuda; Fiscal Year: 2005..We also expect the conference to be attractive to educated lay individuals such as consumers, family members, advocates, and members of the press who are interested in tracking the development of knowledge in this area. ..
- ALCOHOL DEPENDENCE--GENERAL POPULATION VALIDITYDeborah Hasin; Fiscal Year: 2003..abstract_text> ..
- Biology of Risk of PTSD in Holocaust Survivor OffspringRachel Yehuda; Fiscal Year: 2006..The subjects will be further subdivided so that there are 40 in each group with and without PTSD; half of each subgroup will have a current depressive disorder. Thus, we will recruit a total of 20 subjects in each of 12 subgroups. ..
- Genetics, Endocrinology and PTSD Risk in the PopulationRachel Yehuda; Fiscal Year: 2006..The development of models of prevention and treatment of PTSD can only occur following an understanding of individual risk factors and their interactions with event exposure. ..
- DEVELOPING AN ISRAELI VERSION OF THE HRS/SHARE PROJECTHoward Litwin; Fiscal Year: 2006..abstract_text> ..
- CANCER SCREENING COMPLIANCE IN HEREDITARY COLON CANCERSapna Syngal; Fiscal Year: 2005....
- CARCR Confrence SupportHoda Anton Culver; Fiscal Year: 2005..The March 2005 conference, which is the first to be covered by this proposal, will be held at a still to be determined site in Northern California. ..
- Genome-wide analysis of genetic variation and expression.Vivian G Cheung; Fiscal Year: 2010..Therefore, the molecular and analytical approaches developed here can be generalized and applied to the study of other quantitative traits in humans, including complex genetic diseases. ..
- Characterization of the Chromosome 17q23 AmpliconFergus Couch; Fiscal Year: 2006..Thus, the project may involve a complete transition from benchtop to bedside. Finally, the amplified and overexpressed genes may prove useful as important targets of gene, pharmacological, and immunological therapy in the future. ..
- Positional Gene Identification of Complex TraitsChristopher Amos; Fiscal Year: 2006..Finally, we will apply the methods that we are developing as part of existing studies of obesity, cancer-predisposition and rheumatoid arthritis. ..
- NCI CFRBCCS INFORMATICS CENTER AT UCIHoda Anton Culver; Fiscal Year: 2005....
- GENETIC EPIDEMIOLOGY OF PROSTATE CANCERAlice Whittemore; Fiscal Year: 2008..As members of the ICPCG, our long-term aim is to pursue with this group any promising leads identified in this project. ..
- The Natural History of Pediatric Crohn's DiseaseMarla Dubinsky; Fiscal Year: 2008..abstract_text> ..
- US Psychiatric Genetics Research Training ProgramMichael Escamilla; Fiscal Year: 2007..Specific aims of the program follow. [unreadable] [unreadable]..
- Lanaguge, Community, and Older Immigrant HouseholdsJeffrey Burr; Fiscal Year: 2006..Third, using the double cohort method, age and immigration cohort effects on patterns of household complexity are examined to test life cycle and assimilation hypotheses. ..
- Parental Expression of Immune Responses In Pediatric Crohn's DiseaseMarla Dubinsky; Fiscal Year: 2008..unreadable] [unreadable]..
- Breast Cancer Genomics in a Founder PopulationMary Claire King; Fiscal Year: 2008..Discovery of additional breast cancer genes of moderate penetrance in the AJ population will be important to women both in this population and generally. ..
- Genetics of Bipolar Disorder in Latino PopulationsMichael Escamilla; Fiscal Year: 2009....
- Severe Asthma and the Glucocorticoid Receptor ComplexGregory Hawkins; Fiscal Year: 2006..This will also lay the ground work for future functional studies using coding sequence variants identified in the GR complex proteins. [unreadable] [unreadable] [unreadable]..
- Notch Signaling in Beta Cell Development and RegenerationMARSHALL PERMUTT; Fiscal Year: 2008..Experiments are proposed to define the mechanisms. The results of these experiments may serve to accelerate efforts towards the development of cell-based therapies for insulin delivery. [unreadable] [unreadable] [unreadable]..
- High Density Association Analysis of Lung CancerChristopher I Amos; Fiscal Year: 2010..We are collaborating with the International Lung Cancer Consortium so that it can further validate our findings for a variety of different populations, in future initiatives. ..
- Genetics of Hearing Loss in Middle Eastern FamiliesMary Claire King; Fiscal Year: 2010....
- Examination of the role of LPIN2 variations in skin and bone inflammationHatem El Shanti; Fiscal Year: 2007..Understanding the mechanisms behind psoriasis and CRMO is very important for the development of appropriate therapy. [unreadable] [unreadable] [unreadable]..
- GENETICS STUDIES OF MYOPIADwight Stambolian; Fiscal Year: 2002..This will have an even greater relevance if we are successful at defining the refractive component(s) of the eye which is responsible for the development of myopia. ..
- GENETIC STUDIES OF AUTOSOMAL DOMINANT CATARACTSDwight Stambolian; Fiscal Year: 2003..5. The four most interesting mutations based on phenotype and unique location on the mouse chromosome in specific aim #4 will be selected and the developmental histopathology studied. ..