Genomes and Genes
Summary: Persons living in the United States having origins in any of the black groups of Africa.
Publications346 found, 100 shown here
- Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination SurveyEarl S Ford
Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
JAMA 287:356-9. 2002..Limited information is available about the prevalence of the metabolic syndrome in the United States, however...
- The structure of haplotype blocks in the human genomeStacey B Gabriel
Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
Science 296:2225-9. 2002..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
- Race, breast cancer subtypes, and survival in the Carolina Breast Cancer StudyLisa A Carey
Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
JAMA 295:2492-502. 2006..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B...
- Sensitive detection of chromosomal segments of distinct ancestry in admixed populationsAlkes L Price
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
PLoS Genet 5:e1000519. 2009..the method empirically by applying it to populations that have experienced recent and ancient admixture: 935 African Americans from the United States and 29 Mozabites from North Africa...
- A genome-wide association study of hypertension and blood pressure in African AmericansAdebowale Adeyemo
Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
PLoS Genet 5:e1000564. 2009..genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a population group in the United States that is disproportionately affected by hypertension and associated ..
- The genetic structure and history of Africans and African AmericansSarah A Tishkoff
Department of Biology, University of Maryland, College Park, MD 20742, USA
Science 324:1035-44. 2009..The ancestry of African Americans is predominantly from Niger-Kordofanian (approximately 71%), European (approximately 13%), and other African ..
- The contextual effect of the local food environment on residents' diets: the atherosclerosis risk in communities studyKimberly Morland
Department of Epidemiology, University of North Carolina, Chapel Hill, USA
Am J Public Health 92:1761-7. 2002..We studied the association between the local food environment and residents' report of recommended dietary intake...
- Association of trypanolytic ApoL1 variants with kidney disease in African AmericansGiulio Genovese
Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Science 329:841-5. 2010b>African Americans have higher rates of kidney disease than European Americans...
- Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescentsJose R Fernandez
Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
J Pediatr 145:439-44. 2004..To describe and provide estimates of the distribution of waist circumference (WC) according to percentiles in African-, European-, and Mexican-American children, and to test for group differences at different percentiles...
- The landscape of recombination in African AmericansAnjali G Hinch
Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK
Nature 476:170-5. 2011..1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans...
- Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004Adit A Ginde
Department of Emergency Medicine, University of Colorado Denver School of Medicine, Aurora, 80045, USA
Arch Intern Med 169:626-32. 2009..Vitamin D insufficiency is associated with suboptimal health. The prevalence of vitamin D insufficiency may be rising, but population-based trends are uncertain. We sought to evaluate US population trends in vitamin D insufficiency...
- Tumor immunobiological differences in prostate cancer between African-American and European-American menTiffany A Wallace
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
Cancer Res 68:927-36. 2008..The profiles portray the existence of a distinct tumor microenvironment in these two patient groups...
- Cancer statistics for African Americans, 2013Carol DeSantis
Surveillance and Health Services Research, American Cancer Society, Atlanta, GA 30303, USA
CA Cancer J Clin 63:151-66. 2013In this article, the American Cancer Society estimates the number of new cancer cases and deaths for African Americans and compiles the most recent data on cancer incidence, mortality, survival, and screening prevalence based upon ..
- Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe ProjectGuillaume Lettre
Montreal Heart Institute, Montreal, Canada
PLoS Genet 7:e1001300. 2011Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C), hypertension, smoking, ..
- A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African AmericansS S Harris
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Diabetes Obes Metab 14:789-94. 2012Vitamin D deficiency may increase the risk for type 2 diabetes. African Americans tend to have poor vitamin D status and increased risk of diabetes, but effects of vitamin D supplementation on components of diabetes risk have not been ..
- The reasons for geographic and racial differences in stroke study: objectives and designVirginia J Howard
Department of Epidemiology, University of Alabama at Birmingham, USA
Neuroepidemiology 25:135-43. 2005..Participants are followed via telephone at 6-month intervals for identification of stroke events. The novel aspects of the REGARDS study allow for the creation of a national cohort to address geographic and ethnic differences in stroke...
- State of disparities in cardiovascular health in the United StatesGeorge A Mensah
Office of the Director, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Mail Stop K 40, 4770 Buford Hwy NE, Atlanta, GA 30341 3717, USA
Circulation 111:1233-41. 2005..Having timely access to current data on disparities is important for policy and program development. Accordingly, we assessed the current magnitude of disparities in cardiovascular disease (CVD) and its risk factors in the United States...
- Estimation of individual admixture: analytical and study design considerationsHua Tang
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genet Epidemiol 28:289-301. 2005..g., simulations) not possible by Bayesian methods. Our simulation results demonstrate that inclusion of ancestral populations or their surrogates in the analysis is required by any method of IA estimation to obtain reasonable results...
- Skin pigmentation, biogeographical ancestry and admixture mappingMark D Shriver
Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
Hum Genet 112:387-99. 2003..We have genotyped these markers in two population samples with primarily African ancestry, viz. African Americans from Washington D.C...
- Revisiting a neglected construct: parenting styles in a child-feeding contextSheryl O Hughes
Department of Pediatrics, Children s Nutrition Research Center, Baylor College of Medicine, 1100 Bates Avenue, Houston, TX 77030 2600, USA
Appetite 44:83-92. 2005..Further, differences were found among the feeding styles on an independent measure of child's body mass index...
- Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E Ïµ4,and the risk of late-onset Alzheimer disease in African AmericansChristiane Reitz
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA
JAMA 309:1483-92. 2013..Identification of disease-associated variants helps identify targets for genetic testing, prevention, and treatment...
- Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)Diane E Bild
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Circulation 111:1313-20. 2005....
- Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African AmericansLaura B Hughes
University of Alabama at Birmingham, 1530 3rd Avenue South, SHEL 210, Birmingham, AL 35294 2182, USA
Arthritis Rheum 62:3547-53. 2010..The influence of these risk alleles has not been comprehensively studied in African Americans. We therefore sought to examine whether these validated RA risk alleles are associated with RA risk in an ..
- Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: a single-institution compilation compared with the National Cancer Institute's Surveillance, Epidemiology, and End Results databaseGloria J Morris
Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Cancer 110:876-84. 2007..Breast carcinomas in African-American patients appear to be more aggressive than in Caucasian patients due to multifactorial differences...
- Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African AmericansPaul J McLaren
Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 21:4334-47. 2012..acid positions demonstrates that HLA-B position 97 is the most significant association with host control in African Americans (omnibus P = 1.2 × 10(-21)) and explains the signal of several HLA-B alleles, including B*57:03...
- Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African AmericansFang Chen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Hum Mol Genet 20:4491-503. 2011..we identified markers in four regions that better capture the association with breast cancer risk in African Americans as defined by the index signal (2q35, 5q11, 10q26 and 19p13)...
- A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) studyUlrike Peters
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Genet 9:e1003171. 2013..However, follow-up studies in African Americans (AA) have shown no support for some of the most consistently BMI-associated FTO index single nucleotide ..
- A genome-wide association search for type 2 diabetes genes in African AmericansNicholette D Palmer
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
PLoS ONE 7:e29202. 2012b>African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity...
- Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African AmericansLisa B Signorello
International Epidemiology Institute, Rockville, Maryland, United States of America
PLoS ONE 6:e28623. 2011..b>African Americans are a group at particularly high risk for vitamin D insufficiency but to date have been virtually absent ..
- Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) studyAlvaro Alonso
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd Street, Minneapolis, MN 55454 USA
Am Heart J 158:111-7. 2009To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans.
- Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe)Cara L Carty
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Hum Mol Genet 21:711-20. 2012..Specifically, we identify new loci that may reflect population-specific regulation of height and report several known height loci that are important in determining height in African-descent populations...
- Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE studySteven Buyske
Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America
PLoS ONE 7:e35651. 2012..It has 196,725 SNPs concentrated in 257 genomic regions. We evaluated the Metabochip in 5,863 African Americans; 89% of all SNPs passed rigorous quality control with a call rate of 99.9%...
- APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathyJeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA
J Am Soc Nephrol 22:2129-37. 2011Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease in African Americans, but whether APOL1-associated glomerular disease has a distinct clinical phenotype is unknown...
- H.U.B city steps: methods and early findings from a community-based participatory research trial to reduce blood pressure among African AmericansJamie M Zoellner
Department of Human Nutrition, Foods and Exercise, Virginia Tech, 1981 Kraft Drive 0913, Blacksburg, VA 24061, USA
Int J Behav Nutr Phys Act 8:59. 2011..This behavioral study describes the conceptual frameworks, methods, and early findings related to the reach, adoption, implementation, and effectiveness on primary blood pressure outcomes...
- Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-AmericansE Ramos
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
Diabetologia 54:783-8. 2011..Thus, it is important to conduct replication analyses in populations with non-European ancestry to identify shared loci associated with FPG across populations...
- A genome-wide association study of serum uric acid in African AmericansBashira A Charles
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
BMC Med Genomics 4:17. 2011....
- The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-AmericansNancy L Saccone
Department of Genetics, Washington University, St Louis, Missouri 63110, UA
Cancer Res 69:6848-56. 2009..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
- Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemiaJun J Yang
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Nat Genet 43:237-41. 2011..after childhood ALL have been reported in many clinical studies, with poorer survival observed among African Americans or those with Hispanic ethnicity when compared with European Americans or Asians...
- Genome-wide association of anthropometric traits in African- and African-derived populationsSun J Kang
Department of Biostatistics and Epidemiology, Case Western Reserve University, Cleveland, OH 44106, USA
Hum Mol Genet 19:2725-38. 2010..Meta-analysis of this data set with additional studies in African-ancestry populations will be helpful to improve power to detect novel associations...
- Achieving weight and activity goals among diabetes prevention program lifestyle participantsRena R Wing
Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
Obes Res 12:1426-34. 2004..This paper examines demographic, psychosocial, and behavioral factors related to achieving weight loss and physical activity goals in the DPP lifestyle participants...
- Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer RegistryKatrina R Bauer
Public Health Institute California Cancer Registry, Sacramento, California 95815 4402, USA
Cancer 109:1721-8. 2007..The triple-negative phenotype is important because of its relation to the basal-like subtype of breast cancer...
- A regional food-frequency questionnaire for the US Mississippi DeltaKatherine L Tucker
Jean Mayer US Department of Agriculture USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Public Health Nutr 8:87-96. 2005....
- Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GAMary Jo Lund
Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA
Breast Cancer Res Treat 113:357-70. 2009..This study examines association of the ER/PR/HER2 subtypes with race and breast cancer survival...
- Racial disparities in cancer survival among randomized clinical trials patients of the Southwest Oncology GroupKathy S Albain
Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA
J Natl Cancer Inst 101:984-92. 2009..Our objective was to determine whether racial disparities in survival exist among patients enrolled in consecutive trials conducted by the Southwest Oncology Group (SWOG)...
- Cultural sensitivity in public health: defined and demystifiedK Resnicow
Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
Ethn Dis 9:10-21. 1999..Techniques, borrowed from social marketing and health communication theory, for developing culturally sensitive interventions are described. Research is needed to determine the effectiveness of culturally sensitive programs...
- Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic studyChristopher J Lessard
Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Am J Hum Genet 88:83-91. 2011....
- Genetic risk assessment of type 2 diabetes-associated polymorphisms in African AmericansJessica N Cooke
Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
Diabetes Care 35:287-92. 2012..These SNPs have not been extensively investigated for individual and cumulative effects on T2D risk in African Americans.
- The socioeconomic gradient of diabetes prevalence, awareness, treatment, and control among African Americans in the Jackson Heart StudyMario Sims
Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA
Ann Epidemiol 21:892-8. 2011Little research has focused on the social patterning of diabetes among African Americans. We examined the relationship between socioeconomic status (SES) and the prevalence, awareness, treatment, and control of diabetes among African ..
- Evaluating the dissemination of Body & Soul, an evidence-based fruit and vegetable intake intervention: challenges for dissemination and implementation researchMarlyn Allicock
Gillings School of Global Public Health, Department of Nutrition, University of North Carolina at Chapel Hill, NC 27599, USA
J Nutr Educ Behav 44:530-8. 2012..To evaluate whether the evidence-based Body & Soul program, when disseminated and implemented without researcher or agency involvement and support, would achieve results similar to those of earlier efficacy and effectiveness trials...
- Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trialJackson T Wright
Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106 5014, USA
JAMA 288:2421-31. 2002..Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD...
- High blood pressure trends in children and adolescents in national surveys, 1963 to 2002Rebecca Din-Dzietham
Morehouse School of Medicine, Social Epidemiology Research Center, 520 Westview Dr SW, NCPC 315, Atlanta, GA 30310 1495, USA
Circulation 116:1488-96. 2007..In the face of growing obesity, we sought to assess high blood pressure (HBP) secular trends in children and adolescents enrolled in national surveys and to determine whether the HBP trend reversed its course with the rise in obesity...
- Church-based health promotion interventions: evidence and lessons learnedMarci Kramish Campbell
UNC Lineberger Comprehensive Cancer Center and the Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7461 USA
Annu Rev Public Health 28:213-34. 2007..For African Americans, health interventions that incorporate spiritual and cultural contextualization have been effective...
- Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorderPingxing Xie
Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
Neuropsychopharmacology 35:1684-92. 2010..One thousand one hundred forty-three European Americans (EAs) and 1284 African Americans (AAs) recruited for studies of the genetics of substance dependence were also screened for lifetime PTSD...
- A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americansRehan Qayyum
GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
PLoS Genet 8:e1002491. 2012..In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling African Americans, our aim was to identify novel genetic variants associated with platelet count and MPV...
- Weight loss and African-American women: a systematic review of the behavioural weight loss intervention literatureM L Fitzgibbon
Departments of Medicine, University of Illinois at Chicago, Chicago, IL 60608, USA
Obes Rev 13:193-213. 2012..This will help enable the adoption of healthier behaviours for this group of women disproportionately affected by obesity...
- Intramyocellular lipid and insulin resistance: differential relationships in European and African AmericansKatherine H Ingram
Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
Obesity (Silver Spring) 19:1469-75. 2011..study the interrelationships among IMCL, insulin sensitivity, and adiposity in European Americans (EAs) and African Americans (AAs)...
- Racial and ethnic differences in cardiovascular disease risk factors: a systematic reviewAnita K Kurian
School of Public Health, University of North Texas Health Science Center, Plano Tarrant County Public Health, Fort Worth, Texas, USA
Ethn Dis 17:143-52. 2007....
- Text messaging to motivate walking in older African Americans: a randomized controlled trialBang Hyun Kim
Office of Minority Health and Health Disparities, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC 20003, USA
Am J Prev Med 44:71-5. 2013..Older minority populations can benefit from increased physical activity, especially walking. Text messaging interventions have the potential to encourage positive changes in health behavior in these groups...
- Frequency of EGFR and KRAS mutations in lung adenocarcinomas in African AmericansJ Matthew Reinersman
Memorial Sloan Kettering Cancer Center, New York City, New York 10065, USA
J Thorac Oncol 6:28-31. 2011..KRAS mutations confer resistance to EGFR-tyrosine kinase inhibitors. The prevalence of these mutations in African American patients has not been thoroughly investigated...
- New approaches to disease mapping in admixed populationsMichael F Seldin
Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA
Nat Rev Genet 12:523-8. 2011Admixed populations such as African Americans and Hispanic Americans are often medically underserved and bear a disproportionately high burden of disease...
- Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African AmericansBarry I Freedman
Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
PLoS Genet 7:e1002150. 2011..APOL1 on chromosome 22 (c22) are powerfully associated with non-diabetic end-stage renal disease (ESRD) in African Americans (AAs)...
- Prevalence of obesity among US preschool children in different racial and ethnic groupsSarah E Anderson
Division of Epidemiology, College of Public Health, The Ohio State University, B216 Starling Loving Hall, 320 W 10th Avenue, Columbus, OH 43210, USA
Arch Pediatr Adolesc Med 163:344-8. 2009..To estimate the prevalence of obesity in 5 major racial/ethnic groups in 4-year-old US children...
- The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African AmericansRasika A Mathias
Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
BMC Genet 12:50. 2011....
- Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis ProjectJoanne M Jordan
Thurston Arthritis Research Center and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7280, USA
J Rheumatol 34:172-80. 2007To report contemporary estimates of the prevalence of knee-related osteoarthritis (OA) outcomes in African Americans and Caucasians aged > or = 45 years.
- Race-ethnicity-specific waist circumference cutoffs for identifying cardiovascular disease risk factorsShankuan Zhu
Injury Research Center and Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Am J Clin Nutr 81:409-15. 2005..However, WC cutoffs for other race-ethnicity groups remain unknown...
- Preterm low birth weight and periodontal disease among African AmericansAnanda P Dasanayake
Department of Epidemiology and Health Promotion, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010, USA
Dent Clin North Am 47:115-25, x-xi. 2003b>African Americans consistently experience higher rates of preterm and low birth weight (LBW) deliveries than do whites...
- Evaluation of 11 breast cancer susceptibility loci in African-American womenWei Zheng
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Cancer Epidemiol Biomarkers Prev 18:2761-4. 2009..The results from this study extend some of the recent GWAS findings to African-Americans and may guide future efforts to identify the causal variants for breast cancer...
- Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart StudySteven C Hunt
Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT, USA NHLBI Family Heart Study
Aging Cell 7:451-8. 2008Leukocyte telomere length (LTL) is ostensibly a bio-indicator of human aging. Here we report that African Americans have longer LTL than whites...
- Association of glycemic index and glycemic load with risk of incident coronary heart disease among Whites and African Americans with and without type 2 diabetes: the Atherosclerosis Risk in Communities studyDale S Hardy
Division of Epidemiology, University of Texas School of Public Health, Houston, TX 77225, USA
Ann Epidemiol 20:610-6. 2010In this study we examined whether high glycemic index (GI) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes.
- Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studiesKe Hao
Genetics Department, Rosetta Inpharmatics, a Wholly Owned Subsidiary of Merck and Co Inc, Seattle, Washington, USA
BMC Genet 10:27. 2009..Genome-wide imputation of untyped markers allows us to address these issues in a direct fashion...
- Sociocultural correlates of menthol cigarette smoking among adult African Americans in Los AngelesBruce Allen
Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Nicotine Tob Res 9:447-51. 2007..Results indicate that menthol smoking among adult African Americans is at least partly a consequence of a complex set of social and cultural norms...
- Greater risk for HIV infection of black men who have sex with men: a critical literature reviewGregorio A Millett
Centers for Disease Control and Prevention, 1600 Clifton Rd, Mail Stop E 45, Atlanta, GA 30333, USA
Am J Public Health 96:1007-19. 2006..Evidence was insufficient to evaluate the remaining hypotheses.Future studies must address these hypotheses to provide additional explanations for the greater prevalence of HIV infection among Black MSM...
- Weight loss of black, white, and Hispanic men and women in the Diabetes Prevention ProgramDelia S West
Department of Health Behavior and Health Education, University of Arkansas for Medical Sciences, Fay W Boozman College of Public Health, Little Rock, Arkansas, USA
Obesity (Silver Spring) 16:1413-20. 2008....
- Race and gender differences in C-reactive protein levelsAmit Khera
Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
J Am Coll Cardiol 46:464-9. 2005..This study sought to determine whether there are race and gender differences in the distribution of C-reactive protein (CRP) levels...
- Triple-negative breast cancers are increased in black women regardless of age or body mass indexLesley A Stead
Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Breast Cancer Res 11:R18. 2009..We focused on triple-negative (Tneg) tumours (oestrogen receptor (ER), progesterone receptor (PR) and HER2 negative), which are associated with poor prognosis...
- Risk factors for end-stage renal disease: 25-year follow-upChi yuan Hsu
Department of Medicine, University of California, San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
Arch Intern Med 169:342-50. 2009..Few cohort studies have focused on risk factors for end-stage renal disease (ESRD). This investigation evaluated the prognostic value of several potential novel risk factors for ESRD after considering established risk factors...
- FTO genetic variation and association with obesity in West Africans and African AmericansAdebowale Adeyemo
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
Diabetes 59:1549-54. 2010..However, data from populations of African ancestry are limited. We evaluated genetic variation in the FTO gene and investigated associations with obesity in West Africans and African Americans.
- Causes and prevalence of visual impairment among adults in the United StatesNathan Congdon
Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
Arch Ophthalmol 122:477-85. 2004..To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years...
- Are HIV/AIDS conspiracy beliefs a barrier to HIV prevention among African Americans?Laura M Bogart
Health Program, RAND Corporation, Santa Monica, CA 90407 2138, USA
J Acquir Immune Defic Syndr 38:213-8. 2005This study examined endorsement of HIV/AIDS conspiracy beliefs and their relations to consistent condom use and condom attitudes among African Americans.
- Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health InitiativeEric Yi Liu
Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA
Genet Epidemiol 36:107-17. 2012..In this work, we constructed a study-specific reference panel of 3,924 haplotypes using African Americans in the Women's Health Initiative (WHI) genotyped on both the Metabochip and the Affymetrix 6.0 GWAS platform...
- Body and soul. A dietary intervention conducted through African-American churchesKen Resnicow
School of Public Health, University of Michigan, Ann Arbor, Michigan, USA
Am J Prev Med 27:97-105. 2004..a national voluntary agency (American Cancer Society), and the National Institutes of Health to disseminate and evaluate under real-world conditions the impact of previously developed dietary interventions for African Americans.
- Socioeconomic disparities in metabolic syndrome differ by gender: evidence from NHANES IIIEric B Loucks
Department of Psychiatry and Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
Ann Epidemiol 17:19-26. 2007..The aim of the study is to examine whether socioeconomic position (SEP) is associated with metabolic syndrome and whether the association differs by gender and race/ethnicity...
- Racial and ethnic differences in secular trends for childhood BMI, weight, and heightDavid S Freedman
Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Obesity (Silver Spring) 14:301-8. 2006..The prevalence of childhood overweight in the United States has markedly increased over the last 30 years. We examined differences in the secular trends for BMI, weight, and height among white, black, and Mexican-American children...
- Host determinants of HIV-1 control in African AmericansKimberly Pelak
Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
J Infect Dis 201:1141-9. 2010..a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the ..
- Ancestry informative marker panels for African Americans based on subsets of commercially available SNP arraysArti Tandon
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genet Epidemiol 35:80-3. 2011Admixture mapping is a widely used method for localizing disease genes in African Americans. Most current methods for inferring ancestry at each locus in the genome use a few thousand single nucleotide polymorphisms (SNPs) that are very ..
- MYH9 is associated with nondiabetic end-stage renal disease in African AmericansW H Linda Kao
Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
Nat Genet 40:1185-92. 2008As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European ..
- Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populationsPingxing Xie
Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
Arch Gen Psychiatry 66:1201-9. 2009..Previous studies generally focused on its effect on depressive symptoms; little is known about its moderation of the development of posttraumatic stress disorder (PTSD)...
- Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African AmericansKatherine Y King
Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, United States of America
PLoS ONE 6:e16317. 2011..Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1...
- Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) projectRenate B Schnabel
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
Circ Cardiovasc Genet 4:557-64. 2011The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated.
- Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource studyErvin R Fox
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
Hum Mol Genet 20:2273-84. 2011The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA...
- Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndromeSusan Sergeant
The Center for Botanical Lipids and Inflammatory Disease Prevention, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
Br J Nutr 107:547-55. 2012..Compared with European Americans (EAm), African Americans (AfAm) exhibited markedly higher serum levels of arachidonic acid (AA) (EAm 7·9 (sd 2·1), AfAm 9·8 (sd 1·..
- A comprehensive genetic association study of Alzheimer disease in African AmericansMark W Logue
Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Arch Neurol 68:1569-79. 2011To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide association studies of whites.
- Candidate gene association resource (CARe): design, methods, and proof of conceptKiran Musunuru
Broad Institute, Cambridge, MA 02142, USA
Circ Cardiovasc Genet 3:267-75. 2010..The goals of CARe include the discovery of new variants associated with traits using a candidate gene approach and the discovery of new variants using the genome-wide association mapping approach specifically in African Americans.
- Genetic ancestry in lung-function predictionsRajesh Kumar
Division of Allergy and Immunology, Children s Memorial Hospital, 2300 Children s Plaza, Box 60, Chicago IL 60614, USA
N Engl J Med 363:321-30. 2010....
- Social resources and cognitive decline in a population of older African Americans and whitesL L Barnes
Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
Neurology 63:2322-6. 2004..To examine the relation of social resources and cognitive decline in older adults...
- Vitamin D deficiency in systemic lupus erythematosusDiane L Kamen
Medical University of South Carolina, Charleston, SC, USA
Autoimmun Rev 5:114-7. 2006..Overall, 67% of the subjects were vitamin D deficient, with mean levels significantly lower among African Americans (15.9 ng/ml) compared to Caucasians (31.3 ng/ml)...
- Characterizing the admixed African ancestry of African AmericansFouad Zakharia
Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Genome Biol 10:R141. 2009..applied recently developed statistical and computational techniques to the question of African ancestry in African Americans by using data on more than 450,000 single-nucleotide polymorphisms (SNPs) genotyped in 94 Africans of ..
- Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control studyChristopher I Amos
Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Natl Cancer Inst 102:1199-205. 2010..Thus, among African American persons, multiple loci in the region of chromosome 15q25.1 appear to be strongly associated with lung cancer risk...
- Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African AmericansJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
Int J Cancer 123:2095-104. 2008..association between nucleotide excision repair (NER) variants and lung cancer risk have included Latinos and African Americans. We examine variants in 6 NER genes (ERCC2, ERCC4, ERCC5, LIG1, RAD23B and XPC) in association with primary ..
- Physical activity social support and middle- and older-aged minority women: results from a US surveyA A Eyler
Prevention Research Center, Saint Louis University School of Public Health, MO 63376, USA
Soc Sci Med 49:781-9. 1999..Research on the determinants of physical activity have indicated that social support is one of the strongest correlates, but little is known about this relation in important subgroups of middle and older-aged women...
- A randomized controlled trial of weight reduction and exercise for diabetes management in older African-American subjectsT D Agurs-Collins
Division of Epidemiology and Cancer Control, Howard University Cancer Center, Washington, DC 20006, USA
Diabetes Care 20:1503-11. 1997..To evaluate a weight loss and exercise program designed to improve diabetes management in older African-Americans...
- Genome-wide recombination as a risk factor for nondisjunctionNATASHA D HOLLIS; Fiscal Year: 2010..The reference letters are strong. She has the necessary package to excel as a pre-doctoral fellow. ..
- Prostate, Lung, Colorectal and Ovarian (PLCO) Screening TrialMona Fouad; Fiscal Year: 2013..One site in Detroit, MI focused efforts on increasing the participation of African Americans. A site in Denver, CO hired Spanish speaking staff to enhance the number of Hispanic Americans enrolled in ..
- Prostate, Lung, Colorectal and Ovarian (PLCO) Screening TrialBARBARA O'BRIEN; Fiscal Year: 2013..One site in Detroit, MI focused efforts on increasing the participation of African Americans. A site in Denver, CO hired Spanish speaking staff to enhance the number of Hispanic Americans enrolled in ..
- The role of Fli1 in T cell function and the pathogenesis of lupusTamara K Nowling; Fiscal Year: 2011..Lupus predominantly afflicts women and African Americans/Hispanics...
- A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human StooFarid E Ahmed; Fiscal Year: 2010..Since 1990, the mortality in African Americans has decreased from about 30 to 25 per 100,000 populations, with higher mortality in men than women, and ..
- Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular FunctionANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010DESCRIPTION (provided by applicant): Vitamin D deficiency is much more common in African Americans than whites...
- Pathogenesis of the Metabolic SyndromeW Timothy Garvey; Fiscal Year: 2013..The first clue was that IMCL was completely independent of insulin sensitivity in African Americans, while oxidative stress related to lipid peroxidation in muscle was predictive of insulin resistance in both ..
- Mechanisms of Endothelin 1-Induced Sickle Cell PathologyAlicia Rivera; Fiscal Year: 2011..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
- Effects of Standardized Aerobic Exercise-Training on Neurocognitive and NeurodegeThomas O Obisesan; Fiscal Year: 2010DESCRIPTION (provided by applicant): The primary purpose of this pilot study is to determine whether African Americans (AA) with mild AD (AD) can be enrolled and retained in a 6-month aerobic exercise-training study...
- JACKSON HEART STUDYASOKA S SRINIVASAN; Fiscal Year: 2011..abstract_text> ..
- JACKSON HEART STUDYHerman Taylor; Fiscal Year: 2010..abstract_text> ..
- JACKSON HEART STUDYHERMAN ALFRED TAYLOR; Fiscal Year: 2009..abstract_text> ..
- JACKSON HEART STUDYASOKA S SRINIVASAN; Fiscal Year: 2013..abstract_text> ..
- JACKSON HEART STUDYAsoka Srinivasan; Fiscal Year: 2010..abstract_text> ..
- JACKSON HEART STUDYHERMAN ALFRED TAYLOR; Fiscal Year: 2009..abstract_text> ..
- Metabolic impact of fructose restriction in obese childrenJean Marc Schwarz; Fiscal Year: 2013..to TG by DNL, which leads to an increase in liver fat content, VLDL-TG output, and TG levels;but in African Americans, a greater proportion of fructose is converted to glucose, which leads to increased glycemia and insulin ..
- K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresisROBERT FRANKLIN REILLY; Fiscal Year: 2010..Multiple studies show that the prevalence of hypertension is increased in African Americans. Racial differences are even more pronounced for severe forms of hypertension, and severe consequences of ..
- Hiv-1 Infection: Central Serotonergic Activity and its Health ImplicationsAdarsh M Kumar; Fiscal Year: 2010..HIV-1+ cases, N=25;HIV-1- cases N=15), age 25-55 years, belonging to the three ethnic groups (Caucasian, African Americans, Hispanics), who consented during life to participate in the NNTC project...
- A Prospective Study of Adiposity and Subclinical Coronary Artery DiseaseCHRISTINA LYNN WASSEL; Fiscal Year: 2010..The RBS includes participants from 3 ethnic groups (Caucasians, African Americans and Filipinos) who had electron beam computed tomography (EBCT) scans of the chest and abdomen for coronary ..
- Molecular Mechanism of Acrolein-Induced Vascular Toxicity: Role of PPAR gamma andZivar Yousefipour; Fiscal Year: 2013....
- The influence of selenium on biomarkers of prostate cancer riskKARAM E EL-BAYOUMY; Fiscal Year: 2012..cancer (PC) is the second leading cause of cancer-related death in men;aging is a major risk factor and African Americans (AA) are at a higher risk than white Americans (WA)...
- Diet and Gastrointestinal Cancer Risk in African Americans and Rural AfricansSTEPHEN JD O'KEEFE; Fiscal Year: 2012..We are concerned that the reason why African Americans (AAs) have the highest incidence (c1:70,000 of the population) and death rate from colon cancer in the USA ..
- Modulation of cancer prevention by social stressHildegard M Schuller; Fiscal Year: 2010..Low socioeconomic status, which creates chronic psychological stress and is particularly prevalent in African Americans, is associated with a significantly higher incidence and mortality of all cancers...
- Biochemical, Biomechanical & Morphological Properties of Quantitative UltrasoundBarbara L McFarlin; Fiscal Year: 2010..prematurity is the second leading cause of infant mortality and the leading cause of infant mortality for African Americans. If birth could be delayed from 30 to 34 weeks gestation, the incidence of: inhospital mortality could be ..
- A novel allele influencing HIV infection among injection drug usersXiao Fang Yu; Fiscal Year: 2012..by established researchers who have had extensive experience in similar types of studies in Caucasians and African Americans is a further advantage...
- CNS Demyelinating Autoimmunity Targeting Water Channel ComplexesSEAN JOSEPH PITTOCK; Fiscal Year: 2013..e., blind or paraparetic) from presumed MS, particularly African Americans, carry a misdiagnosis and will prove to be NMO/AQP4-IgG seropositive...
- Mediators of Atherosclerosis in South Asians Living in AmericaAlka M Kanaya; Fiscal Year: 2013..S. ethnic groups (Whites, African Americans, Latinos, and Chinese Americans)...
- A dataset for the study of the social determinants of health.Peter A Muennig; Fiscal Year: 2010..e., African Americans may be more likely than whites to see the question, "People treat me fairly," as having a racial component), ..
- Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African AmericansELIZABETH GROOMS NESMITH; Fiscal Year: 2010..The overall goal of this project is to examine the effects of cocaine dependency on renal physiology in African Americans (AAs)...
- Endogenous Cardiac Glycosides in AASKBrad C Astor; Fiscal Year: 2010..b>African Americans are disproportionately afflicted with hypertension and CKD, and may be at higher risk of CVD associated with ..
- Nikkomycin Z treatment of early coccidioidal pneumonia: Phase II clinical trialDAVID LARWOOD; Fiscal Year: 2010..Valley Fever cure would be particularly valuable to groups disproportionately affected by infection such as African Americans, Filipinos, Native American peoples, persons with AIDS or other immunosuppressing conditions, the military, ..
- Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)Daniel Woo; Fiscal Year: 2013..Yet we know little about the biologic differences that lead to this ethnic disparity. Our proposal will compare minorities with ICH to controls from the same population as well as explore genetic, radiographic and outcomes differences. ..
- Forward Genetics to Identify Complex Gene Interactions Involved in GlaucomaElena V Semina; Fiscal Year: 2010..Finally, identified genes will be used to address whether othologous loci are affected in human glaucomas. ..
- Translational Approaches to Reducing Health Disparities in Lung DiseaseJoe G N Garcia; Fiscal Year: 2012..For instance, disproportionately higher number of African Americans and Hispanics are likely to be exposed to air pollutants compared to Caucasians that is one of the major ..
- Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and ProstaIona Cheng; Fiscal Year: 2012..We propose in Aim 1 to characterize the genetic diversity of the mitochondrial genome among African Americans, Japanese Americans, Native Hawaiians, Latinos and Whites...
- Conservative Versus Dialytic Management in Stage V Chronic Kidney DiseaseGLENN MATTHEW CHERTOW; Fiscal Year: 2010..Arguably, since ESRD disproportionately affects minority populations, particularly African Americans, the poor and the uninsured, this type of comparative effectiveness research can influence many of the most ..
- Surgical Indirect Revascularization For Symptomatic Intracranial Aterial StenosisNestor Gonzalez; Fiscal Year: 2013....
- Interactive Multimedia Intervention to Improve Colonoscopy and Bowel Prep AdhereJOHN MATTHEW INADOMI; Fiscal Year: 2012..Adherence to colonoscopy is low among African Americans;moreover, adherence to the colonoscopy preparation is especially low in this population, which contributes ..
- Epidemiology of Putative Causal Variants in the Multiethnic CohortLoic Le Marchand; Fiscal Year: 2012..of older adults (45-75 yrs at baseline) for five US racial/ethnic groups (Japanese Americans, African Americans, European Americans, Latinos and Native Hawaiians) at varying risks of chronic diseases...
- CARDIA Echocardiography Reading CenterJoao A C Lima; Fiscal Year: 2012..abstract_text> ..
- Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the ElderlyNancy Berliner; Fiscal Year: 2013..abstract_text> ..
- NADPH-Oxidase and SLE SusceptibilitySwapan K Nath; Fiscal Year: 2013..Ultimately, a set of novel functional variants will be made available to the scientific community and provide a basis for future biological experiments to define how NADPHO contributes to the pathological mechanisms of lupus. ..
- CARDIA ECHO RC Joao A C Lima; Fiscal Year: 2011..abstract_text> ..
- Coronary Artery Risk Development in Young Adults (CARDIA) Study - CCJames Shikany; Fiscal Year: 2012..abstract_text> ..
- CARDIA ECHO RC CAN 9-8470189Joao Lima; Fiscal Year: 2009..abstract_text> ..
- CARDIA ECHO RC Joao Lima; Fiscal Year: 2010..abstract_text> ..
- FAMU RCMI Pharmaceutical Research CenterKaram F A Soliman; Fiscal Year: 2013..These efforts will result in positive health outcomes in addition to decreasing and eliminating health disparities. ..
- CARDIASharina D Person; Fiscal Year: 2010..abstract_text> ..
- CARDIAO Dale Williams; Fiscal Year: 2011..abstract_text> ..
- Violence Exposure, Immune Function &HIV/AIDS Risks in African American Young AdFROUGH SAADATMAND; Fiscal Year: 2013..Sanders-Phillips, Kathy Significant disparities exist in rates of HIV/AIDS in the United States and African Americans have the highest infection rates in the country...
- Financial Risks and Ethnic/Racial Disparities in Live Kidney DonationTANJALA PURNELL; Fiscal Year: 2011..renal disease target focus of improving rates of kidney transplantation and donation, particularly by African Americans and other ethnic/racial minority groups. In her didactic program, Ms...
- Polymorphism and mutation spectrum in minorities with non-small cell lung cancerDavid P Carbone; Fiscal Year: 2010..The results should provide tremendous insight into the genomic factors which influence susceptibility, pathogenesis, drug sensitivity, and survival in African-Americans with non-small cell lung cancer. ..
- Accelerated Biologic Aging and Risk for Sepsis and Organ Failure Following TraumaELIZABETH GROOMS NESMITH; Fiscal Year: 2012..Research has shown that African Americans (AAs) and persons of low socioeconomic status (SES) have nearly twice the rates of sepsis and organ ..
- Impact of adipokines and insulin resistance on progression of prehypertensionCynthia Cheng; Fiscal Year: 2013..Early patient intervention will minimize cardiovascular risk by averting the development of irreversible vascular/endothelial damage and clinical HTN. ..
- Genetic contributors to diabetes and dyslipidemia in African AmericansMichele M Sale; Fiscal Year: 2010DESCRIPTION (provided by principal investigator): It is estimated that 3.2 million African Americans aged 20 years or older have T2DM...
- The Effects of C-Reactive Protein on AutoimmunityTerry W Du Clos; Fiscal Year: 2013..Therefore, understanding the role this protein plays in the risk for SLE will aid in understanding the cause and treatment of this and other autoimmune diseases in Veterans. ..
- RCT of Stress Reduction in the Secondary Prevention of CHD in African AmericansRobert Schneider; Fiscal Year: 2010..The mortality rate from cardiovascular disease is twice as high in African Americans as white Americans...
- Ubiquitous Mobile Multimedia for Environmental Public Health Outreach and SocialCESAR BANDERA; Fiscal Year: 2010..65% of white adults in the United States searched online for health information in 2008 versus 51% of African Americans and 44% of Hispanics. An alternate mechanism with which to convey visual content (e.g...
- Reasons for Racial Disparities in Venous ThromboembolismNEIL ADRIAN ZAKAI; Fiscal Year: 2010..Though understanding the reasons for this disparity we can begin to formulate public health policies to address this disparity. ..
- HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*Lennox Jeffers; Fiscal Year: 2005..sustained virologic response to a 48-week course of Peginterferon alfa-2a in combination with ribavirin in African Americans as compared to non-Hispanic whites with chronic HCV genotype 1 as assessed at the end of 48-week post-..
- Arterial Baroreflex Function in African Americans at Rest and During ExerciseDavid Keller; Fiscal Year: 2009DESCRIPTION (provided by applicant): African Americans are at higher risk than their Caucasian American counterparts for the development of hypertension with hypertension affecting over 40% of the African American adult population...
- Does Enhanced School-Readiness Affect Adult Health of African Americans?Frances A Campbell; Fiscal Year: 2010..NIH Challenge Grants in Health and Science Research Does Enhanced School-Readiness Affect Adult Health of African Americans? This application addresses Broad Challenge Area (05) Comparative Effectiveness Research, 05-MD-101, Social ..
- VIRAHEP-C Clinical CenterAnna Lok; Fiscal Year: 2005..7 million Americans have evidence of chronic infection. The prevalence of antibody to HCV is higher among African Americans (3.2%) than among the non-Hispanic whites (1.8%)...
- Intensive Outpatient v. Outpatient Treatment with Buprenorphine among African AmeShannon Gwin Mitchell; Fiscal Year: 2010..Populations Background: Although there is relatively little difference in illicit drug use rates between African Americans and Whites, there is are significant differences in terms of the collateral impact of opiate use on these ..
- Disparities in CHD in the Jackson Heart StudyMario Sims; Fiscal Year: 2010..key psychosocial factors (discrimination, stress, and social support) impact coronary heart disease (CHD) in African Americans in Mississippi...
- Resistance to Antiviral Therapy in Chronic Hepatitis CNorah Terrault; Fiscal Year: 2005..virological response (viral clearance) to pegylated interferon plus ribavirin will be compared in 200 African Americans and 200 non-Hispanic whites...
- Application and Dissemination of a Culture-Centered Approach to Tailoring ComparaMohan Jyoti Dutta; Fiscal Year: 2010..The proposed project specifically seeks to develop tailored CERSGs on heart disease targeted toward African Americans in Indiana, given the existing disparities among racial/ethnic groups in the area of heart disease, and the ..
- A web-based tailored health behavior intervention for African American colon cancMarlyn Allicock; Fiscal Year: 2010DESCRIPTION (provided by applicant): Background African Americans experience disproportionate morbidity and mortality from colon and rectal cancers...
- Racial Differences in IFN Transcriptional ResponseDaryl Lau; Fiscal Year: 2009..Approximately 2.4 million Americans have chronic hepatitis C infection and the rate is higher among the African Americans (3.2%) than among the Caucasian population (1.5%)...
- Accelerated Repair of Vascular Injury in Diabetes by TGF-beta Modified Stem CellsSTEPHEN BARTELMEZ; Fiscal Year: 2009..Our focus is to demonstrate proof of principle that adult HSC can be effectively used to repair infarcted coronary vessels and eventually greatly improve the quality and duration of these patient's lives. ..
- Cost Effectiveness of a Home Support Program for Depression in Black EldersLaura N Gitlin; Fiscal Year: 2010..of our currently funded randomized controlled trial (NIMH R01MH079814) "Treating Depression in Older African Americans") that tests a novel 10- session home-based intervention to treat depression in older community-dwelling ..
- HIV EPIDEMIOLOGY AMONG RURAL AFRICAN-AMERICANSAdaora Adimora; Fiscal Year: 1999HIV infection has emerged as a major public health problem among African Americans in rural regions of the Southeastern United States, where the epidemics of gonorrhea, syphilis, and other curable STDs have also escalated...