asian continental ancestry group

Summary

Summary: Individuals whose ancestral origins are in the continent of Asia.

Top Publications

  1. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
  2. pmc Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
    Yoon Shin Cho
    Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk Do, Cheongwon Gun, Gangoe myeon, Yeonje ri, Korea
    Nat Genet 44:67-72. 2012
  3. ncbi A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    Yoon Shin Cho
    Center for Genome Science, National Institute of Health, Seoul, Korea
    Nat Genet 41:527-34. 2009
  4. pmc Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
    Jaspal S Kooner
    National Heart and Lung Institute NHLI, Imperial College London, Hammersmith Hospital, London, UK
    Nat Genet 43:984-9. 2011
  5. ncbi Genetic evidence for high-altitude adaptation in Tibet
    Tatum S Simonson
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Science 329:72-5. 2010
  6. pmc Meta-analysis identifies common variants associated with body mass index in east Asians
    Wanqing Wen
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Genet 44:307-11. 2012
  7. ncbi Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    Hisayuki Shigematsu
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    J Natl Cancer Inst 97:339-46. 2005
  8. ncbi SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
  9. pmc Association between body-mass index and risk of death in more than 1 million Asians
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    N Engl J Med 364:719-29. 2011
  10. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010

Detail Information

Publications365 found, 100 shown here

  1. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
    ..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
  2. pmc Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
    Yoon Shin Cho
    Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk Do, Cheongwon Gun, Gangoe myeon, Yeonje ri, Korea
    Nat Genet 44:67-72. 2012
    ..KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D...
  3. ncbi A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    Yoon Shin Cho
    Center for Genome Science, National Institute of Health, Seoul, Korea
    Nat Genet 41:527-34. 2009
    ..2 x 10(-3), P = 1.4 x 10(-7) and P = 6.0 x 10(-4), respectively). This large-scale GWA analysis of well-characterized Korean population-based samples highlights previously unknown biological pathways...
  4. pmc Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
    Jaspal S Kooner
    National Heart and Lung Institute NHLI, Imperial College London, Hammersmith Hospital, London, UK
    Nat Genet 43:984-9. 2011
    ..001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D...
  5. ncbi Genetic evidence for high-altitude adaptation in Tibet
    Tatum S Simonson
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Science 329:72-5. 2010
    ..Identification of these genes provides support for previously hypothesized mechanisms of high-altitude adaptation and illuminates the complexity of hypoxia-response pathways in humans...
  6. pmc Meta-analysis identifies common variants associated with body mass index in east Asians
    Wanqing Wen
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Genet 44:307-11. 2012
    ..0 × 10(-7). Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations...
  7. ncbi Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    Hisayuki Shigematsu
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    J Natl Cancer Inst 97:339-46. 2005
    ..However, the role of such mutations in the pathogenesis of lung cancers is unclear...
  8. ncbi SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
    ....
  9. pmc Association between body-mass index and risk of death in more than 1 million Asians
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    N Engl J Med 364:719-29. 2011
    ..Most studies that have evaluated the association between the body-mass index (BMI) and the risks of death from any cause and from specific causes have been conducted in populations of European origin...
  10. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010
    ..19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China...
  11. ncbi Genome-wide association study of hematological and biochemical traits in a Japanese population
    Yoichiro Kamatani
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:210-5. 2010
    ..05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated...
  12. ncbi A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese
    Zhibin Hu
    Department of Epidemiology and Biostatistics, Ministry of Education MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China
    Nat Genet 43:792-6. 2011
    ..12 and 22q12.2) were newly identified in the Chinese population. These results suggest that genetic variants in 3q28, 5p15.33, 13q12.12 and 22q12.2 may contribute to the susceptibility of lung cancer in Han Chinese...
  13. ncbi Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship
    P Deurenberg
    Wageningen University, The Netherlands
    Obes Rev 3:141-6. 2002
    ..Hence, the relationship between BF% and BMI is ethnic-specific. For comparisons of obesity prevalence between ethnic groups, universal BMI cut-off points are not appropriate...
  14. ncbi A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
    Yoichiro Kamatani
    Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Nat Genet 41:591-5. 2009
    ..52 and 0.57, respectively). Our findings show that genetic variants in the HLA-DP locus are strongly associated with risk of persistent infection with hepatitis B virus...
  15. ncbi Association of candidate genetic variations with gastric cardia adenocarcinoma in Chinese population: a multiple interaction analysis
    Li Liu
    Department of Epidemiology and Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Carcinogenesis 32:336-42. 2011
    ..These results suggest that MMP-2 C-1306T polymorphism is an important risk factor for GCA and the multifactor interactions among polymorphisms in MMP-2, FASL and FAS play more important role in the development of GCA...
  16. pmc Hsa-miR-499 rs3746444 polymorphism contributes to cancer risk: a meta-analysis of 12 studies
    Man Tang Qiu
    The Fourth Clinical College of Nanjing Medical University, Nanjing, China
    PLoS ONE 7:e50887. 2012
    ..Since 2007, many studies have investigated the association between common SNPs located on hsa-miR-499 (rs3746444) and cancer risks; however, the results were inconclusive...
  17. ncbi A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
    Toshimasa Yamauchi
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:864-8. 2010
    ..78 × 10⁻¹⁴, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D...
  18. pmc A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese
    Fuu Jen Tsai
    School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan
    PLoS Genet 6:e1000847. 2010
    ....
  19. ncbi Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management
    A Misra
    Department of Diabetes and Metabolic Diseases, Fortis Flt Lt Rajan Dhall Hospital, Vasant Kunj, New Delhi
    J Assoc Physicians India 57:163-70. 2009
    ..Till that time, these should be used by clinicians, researchers and policymakers dealing with obesity and related diseases...
  20. pmc Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America
    Roman Kosoy
    Rowe Program in Human Genetics, Department of Biochemistry, University of California Davis, Davis, California 95616, USA
    Hum Mutat 30:69-78. 2009
    ..We conclude that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations...
  21. pmc Genetic variants influencing circulating lipid levels and risk of coronary artery disease
    Dawn M Waterworth
    Genetics Division, GlaxoSmithKline R and D, King of Prussia, PA, USA
    Arterioscler Thromb Vasc Biol 30:2264-76. 2010
    ..We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides...
  22. ncbi A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
    ..61) and rs28421666 (Pcombined=2.49x10(-18), OR=0.67). Our findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules...
  23. pmc Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing
    Hansoo Park
    Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea
    Nat Genet 42:400-5. 2010
    ..These common CNVs in Asian populations will be a useful resource for subsequent genetic studies in these populations, and the new method of calling absolute CNVs will be essential for applying CNV data to personalized medicine...
  24. ncbi A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis
    Yoshinari Miyamoto
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Genet 39:529-33. 2007
    ..Our findings implicate GDF5 as a susceptibility gene for osteoarthritis and suggest that decreased GDF5 expression is involved in the pathogenesis of osteoarthritis...
  25. ncbi Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
    Li Dong Wang
    Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China
    Nat Genet 42:759-63. 2010
    ..PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA...
  26. ncbi Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women
    Zhibin Hu
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    Hum Mutat 30:79-84. 2009
    ..Further functional characterization of miRNA SNPs and their influences on target mRNAs may provide underlying mechanisms for the observed associations and disease etiology...
  27. pmc Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations
    Yukinori Okada
    Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:302-6. 2012
    ..0 × 10(-8)) between a SNP in the KLF9 locus (rs11142387) and one in the MSTN (also known as GDF8) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity...
  28. pmc Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
    H Li
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Diabetologia 55:981-95. 2012
    ..To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians...
  29. ncbi Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT)
    Scott A Lear
    School of Kinesiology, Simon Fraser University, Vancouver, BC, Canada
    Am J Clin Nutr 86:353-9. 2007
    ..Previous studies have not adequately investigated differences in discrete regions of abdominal adiposity across ethnic groups...
  30. pmc A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
    Hyung Cheol Kim
    Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk Do, 363 951, Korea
    Breast Cancer Res 14:R56. 2012
    ..Furthermore, GWAS-identified loci were primarily identified in women of European descent...
  31. pmc Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children
    Lijun Wu
    Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China
    Diabetes 59:3085-9. 2010
    ....
  32. ncbi Defining obesity cut points in a multiethnic population
    Fahad Razak
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Circulation 115:2111-8. 2007
    ..It is unknown whether these cut points are appropriate for non-European populations. We assessed the metabolic risk associated with BMI among South Asians, Chinese, Aboriginals, and Europeans...
  33. pmc Genomic dissection of population substructure of Han Chinese and its implication in association studies
    Shuhua Xu
    Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    Am J Hum Genet 85:762-74. 2009
    ..These signals indicating significant differences among Han Chinese subpopulations should be carefully explained in case they are also detected in association studies, especially when sample sources are diverse...
  34. ncbi Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing
    Akihiro Fujimoto
    Center for Genomic Medicine, RIKEN, Tsurumi, Yokohama, Japan
    Nat Genet 42:931-6. 2010
    ..Our analysis suggests that considerable variation remains undiscovered in the human genome and that whole-genome sequencing is an invaluable tool for obtaining a complete understanding of human genetic variation...
  35. ncbi Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
    Hongxing Zhang
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    Nat Genet 42:755-8. 2010
    ..Our findings provide evidence that the 1p36.22 locus confers susceptibility to HBV-related HCC, and suggest that KIF1B-, UBE4B- or PGD-related pathways might be involved in the pathogenesis of this malignancy...
  36. pmc Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
    Norihiro Kato
    Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
    Nat Genet 43:531-8. 2011
    ..9 × 10(-31) and P = 1.3 × 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention...
  37. pmc Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
    Jie Wen
    Department of Endocrinology, Shanghai Medical College Fudan University, Shanghai, China
    PLoS ONE 5:e9153. 2010
    ..In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabetes GWASs and the metaanalysis, in a Han Chinese cohort...
  38. pmc Genome-wide association study of coronary artery disease in the Japanese
    Fumihiko Takeuchi
    Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
    Eur J Hum Genet 20:333-40. 2012
    ..Thus, three loci confirmed in the Japanese GWA study highlight the likely presence of risk alleles with two types of genetic effects - population specific and common - on susceptibility to CAD...
  39. ncbi Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2
    Wei hua Yue
    Institute of Mental Health, Peking University, Beijing, China
    Nat Genet 43:1228-31. 2011
    ..1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia...
  40. ncbi SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
    Hiroyuki Unoki
    Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Nat Genet 40:1098-102. 2008
    ..5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36)...
  41. ncbi Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations
    Chen Wu
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Nat Genet 43:679-84. 2011
    ..92 × 10(-56)). These findings highlight the involvement of multiple genetic loci and gene-environment interaction in the development of esophageal cancer...
  42. ncbi An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
    Lorraine Southam
    Botnar Research Centre, University of Oxford, UK
    Hum Mol Genet 16:2226-32. 2007
    ..A small but persistent imbalance of GDF5 expression throughout life therefore appears to render an individual more susceptible to OA...
  43. pmc Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS Genet 6:e1000841. 2010
    ..These new genetic findings may help us to gain a better understanding of the disease and the functions of the genes involved...
  44. ncbi CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population
    Hiroko Morisaki
    Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Hum Mutat 33:402-10. 2012
    ....
  45. pmc Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population
    Mengyun Wang
    Cancer Research Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China
    PLoS ONE 7:e31932. 2012
    ....
  46. ncbi Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
    Kazuki Yasuda
    Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo 162 8655, Japan
    Nat Genet 40:1092-7. 2008
    ..Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries...
  47. ncbi Inferring ancestral origin using a single multiplex assay of ancestry-informative marker SNPs
    C Phillips
    Forensic Genetics Department, University of Santiago de Compostela, 15782, and Centro Nacional de Genotipado CeGen, Hospital Clinico Universitario, 15706 Galicia, Spain
    Forensic Sci Int Genet 1:273-80. 2007
    ..This study shows that by choosing SNPs exhibiting marked allele frequency differences between population-groups a practical forensic test for assigning the most likely ancestry can be achieved from a single multiplexed assay...
  48. pmc Identification of new genetic risk variants for type 2 diabetes
    Xiao Ou Shu
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS Genet 6:e1001127. 2010
    ..Our study provides strong evidence for a novel T2D susceptibility locus at 13q31.1 and the presence of new independent risk variants near regions (10p13 and 15q22.2) reported by previous GWAS...
  49. pmc Relationship of obesity with osteoporosis
    Lan Juan Zhao
    Department of Orthopedic Surgery, School of Medicine, University of Missouri Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA
    J Clin Endocrinol Metab 92:1640-6. 2007
    ..Previous analyses, however, did not control for the mechanical loading effects of total body weight on bone mass and may have generated a confounded or even biased relationship between obesity and osteoporosis...
  50. ncbi Type 2 diabetes and cardiovascular disease in South Asians
    Nitin Gholap
    Department of Diabetes Research, University Hospitals of Leicester NHS Trust, Leicester, UK
    Prim Care Diabetes 5:45-56. 2011
    ..Finally the review makes recommendations on various measures including need for further research to tackle this serious health challenge facing the South Asian community...
  51. pmc Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists
    Sanghamitra Sengupta
    Human Genetics Unit, Indian Statistical Institute, Kolkata, India
    Am J Hum Genet 78:202-21. 2006
    ..Our reappraisal indicates that pre-Holocene and Holocene-era--not Indo-European--expansions have shaped the distinctive South Asian Y-chromosome landscape...
  52. ncbi Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations
    Daiki Miki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:893-6. 2010
    ..Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations...
  53. ncbi Medical genetics: a marker for Stevens-Johnson syndrome
    Wen Hung Chung
    Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Nature 428:486. 2004
    ..It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome...
  54. pmc Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations
    Emiko Noguchi
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    PLoS Genet 7:e1002170. 2011
    ..5×10(-10), OR = 1.52, and DPB1*0901: P = 2.0×10(-7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations...
  55. ncbi Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
    Zi Jiang Chen
    Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
    Nat Genet 43:55-9. 2011
    ..73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended...
  56. ncbi Anterior chamber depth and chamber angle and their associations with ocular and general parameters: the Beijing Eye Study
    Liang Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Am J Ophthalmol 145:929-36. 2008
    ..To investigate the normative data of anterior chamber depth (ACD) and angle width and their associations in Chinese adults...
  57. ncbi Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case-control studies
    Jun Wang
    Department of Oncology, General Hospital, Jinan Command of the People s Liberation Army, Shifan Street 25, Tianqiao District, Jinan, 250031, China
    Mol Biol Rep 39:4571-9. 2012
    ..However, further well-designed studies with large sample size will be necessary to validate the risk identified in the current meta-analysis...
  58. ncbi Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population
    Kazuo Hara
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetes 51:536-40. 2002
    ..Based on these findings together with the observation that adiponectin improves insulin sensitivity in animal models, we conclude that the adiponectin gene may be a susceptibility gene for type 2 diabetes...
  59. pmc A genetic variant in miR-196a2 increased digestive system cancer risks: a meta-analysis of 15 case-control studies
    Jing Guo
    Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, China
    PLoS ONE 7:e30585. 2012
    ..The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies...
  60. ncbi An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: the MicroAlbuminuria Prevalence (MAP) Study
    A Y T Wu
    Wu Nephrology and Medical Clinic, Mount Elizabeth Medical Center, 3 Mount Elizabeth, 2258510, Singapore
    Diabetologia 48:17-26. 2005
    ..There is limited information on the prevalence of microalbuminuria among hypertensive type 2 diabetic patients in Asia...
  61. ncbi Hepatocellular carcinoma in the Asia pacific region
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Gastroenterol Hepatol 24:346-53. 2009
    ..However, transmission of HCV by injection drug use, and rising prevalence of obesity and diabetes, both independent risk factors for HCC, may partly offset this decline...
  62. pmc Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor
    Adimoolam Chandrasekar
    Anthropological Survey of India, Southern Regional Centre, Bogadi, Mysore, India
    PLoS ONE 4:e7447. 2009
    ..Northeast Indian mtDNA pool harbors region specific lineages, other Indian lineages and East Asian lineages. We also suggest the establishment of an East Asian gene in North East India through admixture rather than replacement...
  63. ncbi The performance of the Japanese version of the K6 and K10 in the World Mental Health Survey Japan
    Toshi A Furukawa
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Int J Methods Psychiatr Res 17:152-8. 2008
    ..The Japanese versions of the K6 and K10 thus demonstrated screening performances essentially equivalent to those of the original English versions...
  64. ncbi A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis
    Zhiming Lin
    Department of Rheumatology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Nat Genet 44:73-7. 2012
    ..The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis...
  65. ncbi Genetic evidence for the convergent evolution of light skin in Europeans and East Asians
    Heather L Norton
    Department of Anthropology, The Pennsylvania State University, PA, USA
    Mol Biol Evol 24:710-22. 2007
    ..These findings support a case for the recent convergent evolution of a lighter pigmentation phenotype in Europeans and East Asians...
  66. pmc Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals
    Minoru Iwata
    First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama, Japan
    Diabetes Care 35:1763-70. 2012
    ..We evaluated the clinical usefulness of a genetic risk score (GRS) based on 14 well-established variants for type 2 diabetes...
  67. pmc Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women
    Wei Zheng
    Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    J Natl Cancer Inst 102:972-81. 2010
    ..No risk assessment model that incorporates both genetic and clinical predictors is currently available to predict breast cancer risk in this population...
  68. ncbi Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations
    S D Rees
    Diabetes Research Laboratory, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
    Diabetologia 54:1368-74. 2011
    ....
  69. pmc Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies
    Li Wang
    Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
    PLoS ONE 6:e17608. 2011
    ..This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world...
  70. pmc Polymorphisms in the SAA1/2 gene are associated with carotid intima media thickness in healthy Han Chinese subjects: the Cardiovascular Risk Survey
    Xiang Xie
    Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
    PLoS ONE 5:e13997. 2010
    ..We investigated the role of SAA1 and SAA2 gene polymorphisms with IMT in a cohort of healthy subjects participating in the Cardiovascular Risk Survey (CRS) study...
  71. ncbi Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    Xinmei Zhang
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes 57:1246-53. 2008
    ..This study aimed to investigate the relationship between its serum levels and various cardiometabolic parameters in humans...
  72. ncbi Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population
    Yu Xiang
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People s Republic of China
    Mol Biol Rep 39:7019-23. 2012
    ..Further characterization of miRNA SNPs may open new avenue for the study of cancer and therapeutic interventions...
  73. pmc High-throughput sequencing of complete human mtDNA genomes from the Philippines
    Ellen D Gunnarsdóttir
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 21:1-11. 2011
    ..Our results clearly demonstrate that the high-throughput sequencing platforms are the methodology of choice for generating complete mtDNA genome sequences...
  74. ncbi Prevalence of metabolic syndrome using WHO, ATPIII and IDF definitions in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-34)
    M Deepa
    Madras Diabetes Research Foundation, Gopalapuram, Chennai, India
    Diabetes Metab Res Rev 23:127-34. 2007
    ....
  75. pmc Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies
    Yumi Yamaguchi-Kabata
    Laboratory for Statistical Analysis, Center for Genomic Medicine, The Institute of Physical and Chemical Research RIKEN, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Am J Hum Genet 83:445-56. 2008
    ..Simulation studies showed that the inclusion of different proportions of individuals from different regions of Japan in case and control groups can lead to an inflated rate of false-positive results when the sample sizes are large...
  76. pmc Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
    Nan Shen
    Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Proc Natl Acad Sci U S A 107:15838-43. 2010
    ..7-fold higher transcripts of G-allele than C-allele. These data established a functional polymorphism in type I IFN pathway gene TLR7 predisposing to SLE, especially in Chinese and Japanese male subjects...
  77. ncbi A functional polymorphism at 3'UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese
    Chung Ling Liang
    Bright Eyes Clinic, Kaohsiung, Taiwan
    Invest Ophthalmol Vis Sci 52:3500-5. 2011
    ..Conflicting results have been reported regarding the association between PAX6 polymorphism and myopia. This case-control study and functional assay were conducted to identified a functional risk polymorphism for myopia...
  78. ncbi Treatment of chronic hepatitis C in Asia: when East meets West
    Ming Lung Yu
    Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    J Gastroenterol Hepatol 24:336-45. 2009
    ..Given the lack of an effective vaccine, optimal treatment of chronic HCV infection is now perceived as a 'must' in terms of public health strategies, as well as of the clinical setting for individual patients...
  79. pmc Differential contributions of rare and common, coding and noncoding Ret mutations to multifactorial Hirschsprung disease liability
    Eileen Sproat Emison
    Center for Complex Disease Genomics, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 87:60-74. 2010
    ..The RET allelic series, and its genotype-phenotype correlations, shows that success in variant identification in complex disorders may strongly depend on which patients are studied...
  80. pmc Complete Khoisan and Bantu genomes from southern Africa
    Stephan C Schuster
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA
    Nature 463:943-7. 2010
    ..Adding the described variants to current databases will facilitate inclusion of southern Africans in medical research efforts, particularly when family and medical histories can be correlated with genome-wide data...
  81. pmc Mutation analysis of congenital cataract in a Chinese family identified a novel missense mutation in the connexin 46 gene (GJA3)
    Zhou Zhou
    Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Mol Vis 16:713-9. 2010
    ..To identify the genetic defects in a three-generation Chinese family with congenital nuclear cataract...
  82. pmc Five novel mutations of the FRMD7 gene in Chinese families with X-linked infantile nystagmus
    Ningdong Li
    Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin, People s Republic of China
    Mol Vis 14:733-8. 2008
    ..Recently, mutations in FRMD7 were found to be responsible for X-linked idiopathic infantile nystagmus . We investigated the role of the FRMD7 gene mutations in seven Chinese families with infantile nystagmus...
  83. pmc A novel mutation in FRMD7 causing X-linked idiopathic congenital nystagmus in a large family
    Xiang He
    Department of Genetics, National Research Institute for Family Planning, Beijing, China
    Mol Vis 14:56-60. 2008
    ..To identify the gene responsible for causing an X-linked idiopathic congenital nystagmus (XLICN) in a six-generation Chinese family...
  84. pmc Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, U K
    Diabetes 58:2703-8. 2009
    ..Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians...
  85. ncbi Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
    ..4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'...
  86. ncbi 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review
    L D Botto
    Birth Defects and Pediatric Genetics Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 151:862-77. 2000
    ..Studies of the C677T allele in relation to oral clefts, Down syndrome, and fetal anticonvulsant syndrome either have yielded conflicting results or have not been yet replicated...
  87. pmc Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer
    Jirong Long
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Genet 8:e1002532. 2012
    ..This study provides strong evidence for a novel breast cancer susceptibility locus represented by rs9485372, near the TAB2 gene (6q25.1), and identifies two possible susceptibility loci located in the ESR1 gene and 11q24.3, respectively...
  88. pmc Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
    Christopher J Lessard
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Am J Hum Genet 88:83-91. 2011
    ....
  89. pmc Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese
    Yi Ju Li
    Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA
    Ophthalmology 118:368-75. 2011
    ..To determine susceptibility genes for high myopia in Singaporean Chinese...
  90. pmc Diabetic retinopathy in a multi-ethnic cohort in the United States
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Melbourne, Victoria 3002, Australia
    Am J Ophthalmol 141:446-455. 2006
    ..To describe the prevalence and risk factors of diabetic retinopathy in a multi-ethnic US population of whites, blacks, hispanics, and chinese...
  91. ncbi Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration
    Nobuo Fuse
    Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Am J Ophthalmol 151:550-6.e1. 2011
    ..To determine whether polymorphisms in the ARMS2 (LOC387715) gene and the lysyl oxidase-like 1 (LOXL1) gene are associated with age-related macular degeneration (AMD) in Japanese patients...
  92. ncbi Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population
    Satoshi Arakawa
    Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN Yokohama Institute, Yokohama, Japan
    Nat Genet 43:1001-4. 2011
    ..30). Fine mapping revealed that rs13278062, which is known to alter TNFRSF10A transcriptional activity, had the most significant association in 8p21 region. Our results provide new insights into the pathophysiology of exudative AMD...
  93. pmc The diploid genome sequence of an Asian individual
    Jun Wang
    Beijing Genomics Institute at Shenzhen, Shenzhen 518000, China
    Nature 456:60-5. 2008
    ..These variations were considered for their potential biological impact. Our sequence data and analyses demonstrate the potential usefulness of next-generation sequencing technologies for personal genomics...
  94. pmc Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of leber hereditary optic neuropathy in Chinese families with the m.11778G-->a mutation
    Yanli Ji
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Am J Hum Genet 83:760-8. 2008
    ..These findings will assist in further understanding the pathogenesis of LHON and guide future genetic counseling in East Asian patients with m.11778G-->A...
  95. pmc Mitochondrial DNA and Y chromosome variation provides evidence for a recent common ancestry between Native Americans and Indigenous Altaians
    Matthew C Dulik
    Department of Anthropology, University of Pennsylvania, Philadelphia, 19104 6398, USA
    Am J Hum Genet 90:229-46. 2012
    ..These results greatly enhance our understanding of the peopling of Siberia and the Americas...
  96. ncbi Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2 gene as a risk factor independent of alcohol consumption
    Peng Hui
    Division of Molecular Diagnostics, Advanced Medical Research Center, Nihon University School of Medicine, Ooyaguchi Kamimachi, Tokyo, Japan
    Hypertens Res 30:585-92. 2007
    ..There was no interaction between the ALDH2 genotype and alcohol consumption overall or in male subjects. Our results suggest that the ALDH2 genotype is associated with EH independently of alcohol consumption...
  97. ncbi The impact of body build on the relationship between body mass index and percent body fat
    P Deurenberg
    Department of Human Nutrition and Epidemiology, Wageningen Agricultural University, The Netherlands
    Int J Obes Relat Metab Disord 23:537-42. 1999
    ..The objective of the study was to test the hypothesis that differences in the relationship between percent body fat (%BF) and body mass index (BMI) between populations can be explained (in part) by differences in body build...
  98. ncbi Polymorphism near the IL28B gene in Korean hepatitis C virus-infected patients treated with peg-interferon plus ribavirin
    Kwangsoo Lyoo
    Department of Internal Medicine and WHO Collaborating Center on Viral Hepatitis, College of Medicine, The Catholic University of Korea, 137 040 Seoul, Republic of Korea
    J Clin Virol 52:363-6. 2011
    ..Single nucleotide polymorphisms (SNPs) near the IL28B gene have recently been described as predictors of antiviral therapy responses in patients with hepatitis C virus (HCV) genotype-1...
  99. pmc A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals
    Yan Ling
    Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Cardiovasc Diabetol 10:27. 2011
    ..The purpose of this study was to examine whether tagging single nucleotide polymorphisms (SNPs) in the MTNR1B region were associated with type 2 diabetes and related traits in a Han Chinese population...
  100. pmc Copy number variations in East-Asian population and their evolutionary and functional implications
    Seon Hee Yim
    Integrated Research Center for Genome Polymorphism, Seoul St Mary s Hospital, School of Medicine, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Korea
    Hum Mol Genet 19:1001-8. 2010
    ..A total of 476 (11.9%) CNVRs were associated with segmental duplications. CNVS/CNVRs identified in this study will be valuable resources for studying human genome diversity and its association with disease...
  101. ncbi Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population
    Stuart I Davidson
    Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia
    Arthritis Rheum 60:3263-8. 2009
    ..Based on these findings, we undertook the current study to investigate whether single-nucleotide polymorphisms (SNPs) covering the genes ERAP1 and IL23R are associated with AS in a Han Chinese population...

Research Grants75

  1. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
  2. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
  3. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..We seek support for additional blood markers to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis. ..
  4. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans. ..
  5. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2013
    ..Clinical samples also will be tested for unknown pathogens using PCR- sequence based pathogen discovery techniques. PHS 398/2590 (Rev. 06/09) Page 1 Continuation Format Page ..
  6. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..Our goal is to discover estrogens that do not promote cancer, but retain the beneficial of estrogens on body weight and fat accumulation. ..
  7. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
    ....
  8. Mechanisms of virus-induced injury in the brain and spinal cord
    Kenneth L Tyler; Fiscal Year: 2013
    ....
  9. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..The outcomes of this project could be used to plan larger interventions to prevent diabetes in South Asians, a rapidly growing segment of the US population. ..
  10. Mediators of Atherosclerosis in South Asians Living in America
    Alka M Kanaya; Fiscal Year: 2013
    ..centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. These will provide targets for future therapies to prevent or cure the leading cause of death worldwide, cardiovascular disease. ..
  11. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    ..4. To determine the effect of EA on serotoninergic activites in dorsal raphe nucleus and raphe nucleus magnus, the relay centers of central descending inhibitory pathway, in rats with visceral hyperalgesia. ..
  12. Telomere and its bio-regulators as predictors for clinical diabetes in women
    Simin Liu; Fiscal Year: 2010
    ....
  13. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ....
  14. Daily Experience in Adolescence and Biomarkers of Early Risk for Adult Health
    Andrew J Fuligni; Fiscal Year: 2013
    ..An understanding of these processes is necessary for the development of ethnically and culturally relevant prevention efforts. ..
  15. Mechanism and functional role of AKAP79/150 in M current control and excitability
    Mark S Shapiro; Fiscal Year: 2010
    ..The elucidation of the mechanisms and functional role of AKAP79/150 in M-channel activity will shed light on how the nervous system functions in health and disease. ..
  16. Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and Prosta
    Iona Cheng; Fiscal Year: 2012
    ..In addition, we will evaluate heterogeneity of effects by disease sub-groups, environmental factors and known genetic risk factors. ..
  17. Cellular Components Involved in Japanese Encephalitis Virus Entry
    Young Min Lee; Fiscal Year: 2013
    ....
  18. Prolylcarboxypeptidase is a Risk Factor for Cardiovascular Disease
    Alvin H Schmaier; Fiscal Year: 2013
    ..Up-regulation of PRCP may be a target to protect individuals from cardiovascular disease as manifested by hypertension and arterial thrombosis as seen in stroke and MI. ..
  19. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2012
    ..We will also develop similar assays to identify compounds that might inhibit viruses that cause AIDS, yellow fever, Dengue fever, West Nile and Japanese encephalitis. ..
  20. Alternative regulation of ISGs in WNV-infected cells
    Margo A Brinton; Fiscal Year: 2013
    ..Delineation of the viral counteraction mechanism will provide a new cell target for the development of antiviral therapeutics that may be applicable to a broad spectrum of virus infections. ..
  21. Epidemiology of Putative Causal Variants in the Multiethnic Cohort
    Loic Le Marchand; Fiscal Year: 2012
    ..We will coordinate the selection of these variants and endpoints, analytical methods, data analyses, and rapid reporting of results with other cohorts/clinical trials funded through this RFA. ..
  22. NADPH-Oxidase and SLE Susceptibility
    Swapan K Nath; Fiscal Year: 2013
    ..Ultimately, a set of novel functional variants will be made available to the scientific community and provide a basis for future biological experiments to define how NADPHO contributes to the pathological mechanisms of lupus. ..
  23. Social Networks &Breast Cancer Prognosis in the Chinese and US Evaluation Study
    Candyce H Kroenke; Fiscal Year: 2013
    ..It is hoped that addressing gaps in the literature will help point to potential avenues through which relationships with network members might be augmented to promote survival, or managed to mitigate costs of social relationships. ..
  24. System for Rapid Generation of Aptamers for Transplant Therapies
    KAREN QIAN; Fiscal Year: 2010
    ....
  25. Biomarkers of NNK in prediction of lung cancer development in smokers
    Jian Min Yuan; Fiscal Year: 2013
    ..g., quitting smoking. In addition, chemopreventive agents, if available, could be prescribed to high-risk people for protection against lung cancer development. ..
  26. Mechanisms of apoptosis in the central nervous system
    Kenneth Tyler; Fiscal Year: 2009
    ..In addition, the proposed studies will evaluate the role of these genes and pathways as novel therapeutic targets for these diseases. ..
  27. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..These findings are also likely to be of increasing public health importance, as the societal burden of age-related eye disease will likely increase with the aging of this rapidly growing segment of the US population. ..
  28. Evo-epidemiology of Scistosoma mansoni in children in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2010
    ..This information will be valuable for understanding transmission dynamics, spread of novel traits such as drug resistance, and population dynamics of schistosomes. ..
  29. Malaria vaccines modified with TLR agonist adjuvant
    Elizabeth H Nardin; Fiscal Year: 2010
    ..abstract_text> ..
  30. Virus Clearance from the Central Nervous System
    Rodney E Willoughby; Fiscal Year: 2013
    ....
  31. Hampton University Skin of Color Research Institute Skin of Color Symposium 2011:
    Meena Katdare; Fiscal Year: 2011
    ....
  32. An Integrated Study of Mitochondrial Pathways in Colorectal Cancer
    Bharat Thyagarajan; Fiscal Year: 2013
    ....
  33. Flavin-Containing Monooxygenase in Lung
    David E Williams; Fiscal Year: 2013
    ..The knowledge gained will improve treatment approaches in combating TB. ..
  34. Mammalian Mitochondrial One-Carbon Metabolism
    DEAN RAMSAY APPLING; Fiscal Year: 2010
    ..abstract_text> ..
  35. Perfluoroalkyl chemicals and the risk of developing clinical and subclinical CVD
    Anoop Shankar; Fiscal Year: 2012
    ..We will study the association between blood PFCs and cardiovascular disease. If we find an association, it indirectly suggests that reducing PFCs may have a role in preventing these diseases. ..
  36. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..abstract_text> ..
  37. Genome-wide and Linkage Study of Quantitative Emphysema Phenotypes
    Stephen S Rich; Fiscal Year: 2010
    ....
  38. c-Abl-mediated Suppression of Breast Cancer Development and Metastasis
    WILLIAM SCHIEMANN; Fiscal Year: 2013
    ..g., c-Abl for docetaxel response) and treatment options (e.g., Securinine and DPH) for TNBCs. ..
  39. Rational Development of Candidate Attenuated Flavivirus Vaccines
    Tian Wang; Fiscal Year: 2013
    ....
  40. Development of a Recombinant Subunit Vaccine for CCHF
    David E Clements; Fiscal Year: 2013
    ..The successful development of a CCHF recombinant subunit vaccine based on this platform supports the concept that a single platform can be utilized to produce vaccines against a number of viral priority pathogens. ..
  41. Selenium, other risk factors and cognitive decline in rural elderly Chinese
    Sujuan Gao; Fiscal Year: 2013
    ....
  42. Interplay between metabolism and FXR activation in scoparone signaling
    Bingfang Yan; Fiscal Year: 2013
    ..Interestingly, scoparone has been found to exert these very activities. Thus, a confirmation on the functional connection between FXR and scoparone will have broad mechanistic and therapeutic implications. ..
  43. Development of Superactive Analogs of FSH for Human Infertility
    BRUCE DALE WEINTRAUB; Fiscal Year: 2013
    ..We have licensed TR4401 to the worldwide leading veterinary superovulation company, Bioniche, Inc. for veterinary use, with a possible option to also co-develop the analog for human use. ..
  44. Health and Retirement Survey for India
    David Bloom; Fiscal Year: 2009
    ..This research has the potential to inform policy in India and other Asian countries, including China, Japan, and South Korea. ..
  45. Epidemiology of CHD of Men Aged 40+ in US, Hawaii, Japan
    Akira Sekikawa; Fiscal Year: 2012
    ....
  46. Targeting induction of calcium buffer proteins for treatment of viral encephaliti
    John D Morrey; Fiscal Year: 2013
    ..This project could provide new avenues of basic research for WNV and JEV neuro- pathogenesis, and enhance clinical practice for the management of WNV, JEV, and viral encephalitis in general. ..
  47. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey D Esko; Fiscal Year: 2010
    ..In additionwe will explore how the individual isozymes affects heparan sulfate biosynthesis in transfected cells. ..
  48. Mechanism of RNA synthesis and 5'-capping by dengue virus NS5 polymerase
    Kyung H Choi; Fiscal Year: 2013
    ..The results of our studies will lay the foundation for developing antiviral therapeutics to treat these currently untreatable and often deadly infectious diseases. ..
  49. Gut micro biota in patients with multiple sclerosis
    Howard L Weiner; Fiscal Year: 2012
    ..It applies for the first time an important newly developing technology to gain potential basic insights into an autoimmune disease whose underlying pathogenesis remains unknown. ..
  50. Metabolic Engineering of Chinese Hamster Ovary Cells for Production of Heparin
    Susan T Sharfstein; Fiscal Year: 2011
    ..Scale-up the production and recovery of CHO cell metabolically engineered heparin while maintaining chemical and bioequivalence. ..
  51. Genetics of Elevated High Density Lipoprotein Cholesterol
    DANIEL JAMES RADER; Fiscal Year: 2012
    ..We hypothesize that our GWA approach will serve to identify novel genes that cause or predispose to high HDL, generating new targets for HDL raising therapies. ..
  52. Role of Reishi on cell surface proteins and signaling modulation in IBC
    IVETTE SUAREZ; Fiscal Year: 2013
    ....
  53. Impact CYP2D6 Phenotype on Response to Methamphetamine in Humans
    Alison Oliveto; Fiscal Year: 2013
    ..Results of this study may uncover genetically determined metabolic factors that may increase or decrease abuse liability of METH, thereby providing new directions for prevention and treatment for METH dependence. ..
  54. Hypocretin and its receptors Gene Transfer for Narcolepsy
    Meng Liu; Fiscal Year: 2013
    ..Results of this project will serve as a strong base for discovering better alternative treatments for human narcolepsy. ..
  55. Family-Based Genome-wide Association Study for Salt-Sensitivity of Blood Pressure
    Jiang He; Fiscal Year: 2011
    ..In addition, identifying genes related to salt-sensitivity of blood pressure should enable the discovery of new pharmaceutical treatment for hypertension. ..
  56. Adding Hispanics to Ongoing GWAS in Colorectal Cancer
    Jane C Figueiredo; Fiscal Year: 2013
    ....
  57. Prospective evaluation of IGF and IL-6 Dysregulation and Multiple Myeloma
    Graham A Colditz; Fiscal Year: 2010
    ..The team is led from by Drs. Colditz and Anderson and is supported by a senior statistician (Dr. Rosner) and a study director (Dr. Birmann) who is funded, in part, through a K award. ..
  58. Air pollution and fetal growth in China
    Yawei Zhang; Fiscal Year: 2013
    ..Because high energy consumption and increased automobile emissions degrade urban air quality in both developed and developing countries, understanding how ambient air pollution impacts fetal development is of public health significance. ..
  59. Markers of the metabolic syndrome linking type 2 diabetes and MI in South Asia
    Danish Saleheen; Fiscal Year: 2010
    ....
  60. Lay Health Worker Model to Reduce Liver Cancer Disparities in Asian Americans
    Hee Soon Juon; Fiscal Year: 2013
    ....
  61. Establishment of a bioresource for discovery and evaluation of genetic and other
    Danish Saleheen; Fiscal Year: 2010
    ....
  62. An Individually-Tailored Mammography Screening Intervention for Chinese Americans
    Tsu Yin Wu; Fiscal Year: 2010
    ..If the program is shown to be successful, the intervention strategies may serve as a model with other Asian Americans and minority groups, and also improve the utilization of other types of cancer screening tests as well. ..
  63. Behavioral Health Informatics Capacity-Building in China
    Robert Friedman; Fiscal Year: 2009
    ..active lifestyle, healthy eating, and smoking cessation). Should these programs be deployed in China, they would have the capacity to decrease the prevalence of many common chronic diseases and improve their control in the population. ..
  64. YELLOW FEVER 17D-BASED CHIMERIC FLAVIVIRUS VACCINES
    William Wold; Fiscal Year: 2002
    ....
  65. Economic Restructuring and Social Mobility in Japan
    Wei hsin Yu; Fiscal Year: 2009
    ....
  66. US-China-Japan Research Consortium on Herbal Medicines
    David Eisenberg; Fiscal Year: 2004
    ..Lastly, we will determine, as part of this planning grant, the ideal number of partnering institutions (2, 3 or 4) in anticipation of an application for Phase II of this NIH International Center for Research on CAM. ..
  67. Family Processes in Chinese Americans with Diabetes
    Catherine Chesla; Fiscal Year: 2007
    ..This application addresses a National Institute of Nursing Research priority, to investigate cultural and ethnic considerations in health and illness. ..
  68. South Asian Health: From Research to Practice and Policy
    Latha P Palaniappan; Fiscal Year: 2012
    ..This research convening will unite the community, scientists, providers, and policy makers to reduce the large health disparities faced by South Asians in the United States. ..
  69. Improving Methadone Maintenance Treatment Compliance and Outcomes in China
    Yih Ing Hser; Fiscal Year: 2009
    ..The proposed study will identify effective interventions that help to address this important public health problem in China and globally. ..
  70. EPIDEMIOLOGY OF DEMENTIA IN OLDER JAPANESE AMERICANS
    Eric Larson; Fiscal Year: 2000
    ..Finally, standardization efforts between the study sites will focus on the enhancement of the uniformity of diagnostic methods, and cross-site data analysis to compare rates and risk factors. ..
  71. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2010
    ....
  72. Microbicide/Female Condom Acceptability for Sex Workers
    Margaret Weeks; Fiscal Year: 2005
    ..In the last 6 months of the project we will finalize data analyses and an intervention program to promote the female condom and/or microbicides for a subsequent study. ..
  73. GENETICS OF THE METABOLIC SYNDROME IN JAPANESE AMERICANS
    Melissa Austin; Fiscal Year: 2002
    ....
  74. Population-Specific Genetic Determinants of Susceptibility to Chemotherapies
    PETER HUGH O apos DONNELL; Fiscal Year: 2009
    ..For the trainee, the proposal represents a comprehensive learning experience in both basic pharmacogenetic discovery and clinical trial design. ..
  75. A Patient-Centered Strategy to Reduce Diabetes Disparities in Chinese Americans
    Susan Ivey; Fiscal Year: 2009
    ..The clinic's patients, their families, and doctors will work with local researchers to find ways to improve diabetes care in the clinic and to help educate patients and their families. ..