Genomes and Genes
african continental ancestry group
Summary: Individuals whose ancestral origins are in the continent of Africa.
Publications367 found, 100 shown here
- The structure of haplotype blocks in the human genomeStacey B Gabriel
Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
Science 296:2225-9. 2002..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
- Inference of population structure using multilocus genotype data: linked loci and correlated allele frequenciesDaniel Falush
Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumann Strasse 21 22, 10117 Berlin, Germany
Genetics 164:1567-87. 2003..The methods are implemented in a program, structure, version 2.0, which is available at http://pritch.bsd.uchicago.edu...
- The genetic structure and history of Africans and African AmericansSarah A Tishkoff
Department of Biology, University of Maryland, College Park, MD 20742, USA
Science 324:1035-44. 2009..This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies...
- Sensitive detection of chromosomal segments of distinct ancestry in admixed populationsAlkes L Price
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
PLoS Genet 5:e1000519. 2009....
- Genome-wide patterns of population structure and admixture in West Africans and African AmericansKatarzyna Bryc
Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 107:786-91. 2010....
- Assessing the evolutionary impact of amino acid mutations in the human genomeAdam R Boyko
Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA
PLoS Genet 4:e1000083. 2008....
- SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humansRebecca L Lamason
Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Science 310:1782-6. 2005....
- Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9Jonathan Cohen
Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines, Dallas, Texas 75390 9046, USA
Nat Genet 37:161-5. 2005..1%) and were associated with a 40% reduction in plasma levels of LDL cholesterol. These data indicate that common sequence variations have large effects on plasma cholesterol levels in selected populations...
- The history of African gene flow into Southern Europeans, Levantines, and JewsPriya Moorjani
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 7:e1001373. 2011..For the Jewish admixture, we obtain an average estimated date of about 72 generations. This may reflect descent of these groups from a common ancestral population that already had some African ancestry prior to the Jewish Diasporas...
- Epidemiology of basal-like breast cancerRobert C Millikan
Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 109:123-39. 2008..Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity...
- Hunter-gatherer genomic diversity suggests a southern African origin for modern humansBrenna M Henn
Department of Genetics, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 108:5154-62. 2011..However, African hunter-gatherer populations continue to maintain the highest levels of genetic diversity in the world...
- Genome-wide analysis of the structure of the South African Coloured Population in the Western CapeErika de Wit
Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology, DST NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, 7505, South Africa
Hum Genet 128:145-53. 2010..This is consistent with historical data. While of great historical and genealogical interest, this information is also essential for future admixture mapping of disease genes in this population...
- Skin pigmentation, biogeographical ancestry and admixture mappingMark D Shriver
Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
Hum Genet 112:387-99. 2003..The implications and applications of ancestry estimates in biomedical research are discussed...
- Genotype-imputation accuracy across worldwide human populationsLucy Huang
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
Am J Hum Genet 84:235-50. 2009..Our results can serve as a guide for selecting appropriate reference panels for imputation-based GWA analysis in diverse populations...
- Whole-mtDNA genome sequence analysis of ancient African lineagesMary Katherine Gonder
Department of Biology, University of Maryland, MD, USA
Mol Biol Evol 24:757-68. 2007..We propose that a large and diverse human population has persisted in eastern Africa and that eastern Africa may have been an ancient source of dispersion of modern humans both within and outside of Africa...
- Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model for use in epidemiologic surveysShumei S Sun
Lifespan Research Center, Department of Community Health, Wright State University School of Medicine, Dayton, OH 45420, USA
Am J Clin Nutr 77:331-40. 2003..Previous studies to develop and validate bioelectrical impedance analysis (BIA) equations to predict body composition were limited by small sample sizes, sex specificity, and reliance on reference methods that use a 2-component model...
- Methodological challenges of genome-wide association analysis in AfricaYik Ying Teo
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Nat Rev Genet 11:149-60. 2010..We review the methodological challenges and consider how GWA studies in Africa will be transformed by new approaches in statistical imputation and large-scale genome sequencing...
- An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panelsRami Nassir
Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, University of California Davis, Davis, CA 95616, USA
BMC Genet 10:39. 2009..Previously, we described a panel of 128 SNP AIMs that were designed as a tool for ascertaining the origins of subjects from Europe, Sub-Saharan Africa, Americas, and East Asia...
- Ethnic and gender differences in physical activity levels among 9-10-year-old children of white European, South Asian and African-Caribbean origin: the Child Heart Health Study in England (CHASE Study)Christopher G Owen
Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London, UK
Int J Epidemiol 38:1082-93. 2009..We made objective measurements of physical activity in 9-10-year-old British children of South Asian, black African-Caribbean and white European origin...
- Inferring ancestral origin using a single multiplex assay of ancestry-informative marker SNPsC Phillips
Forensic Genetics Department, University of Santiago de Compostela, 15782, and Centro Nacional de Genotipado CeGen, Hospital Clinico Universitario, 15706 Galicia, Spain
Forensic Sci Int Genet 1:273-80. 2007..This study shows that by choosing SNPs exhibiting marked allele frequency differences between population-groups a practical forensic test for assigning the most likely ancestry can be achieved from a single multiplexed assay...
- The emergence of cardiovascular disease during urbanisation of AfricansH H Vorster
Faculty of Health Sciences, Potchefstroomse Universiteit vir Christelike Hoër Onderwys, South Africa
Public Health Nutr 5:239-43. 2002....
- Evaluation of 19 susceptibility loci of breast cancer in women of African ancestryDezheng Huo
Department of Health Studies, University of Chicago, 5841 South Maryland Avenue, MC 2007, Chicago, IL 60637, USA
Carcinogenesis 33:835-40. 2012..Further fine-mapping studies in women of African ancestry will be needed to reveal additional and causal variants for breast cancer...
- The fine-scale structure of recombination rate variation in the human genomeGilean A T McVean
Department of Statistics, University of Oxford, Oxford OX1 3TG, UK
Science 304:581-4. 2004..We demonstrate that recombination hotspots are a ubiquitous feature of the human genome, occurring on average every 200 kilobases or less, but recombination occurs preferentially outside genes...
- Geographic patterns of genome admixture in Latin American MestizosSijia Wang
The Galton Laboratory, Department of Biology, University College London, London, United Kingdom
PLoS Genet 4:e1000037. 2008..Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region...
- The prevalence of metabolic syndrome and determination of the optimal waist circumference cutoff points in a rural South african communityAyesha A Motala
Department of Diabetes and Endocrinology, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa
Diabetes Care 34:1032-7. 2011..To determine the prevalence of metabolic syndrome and to define optimal ethnic-specific waist-circumference cutoff points in a rural South African black community...
- Glucose-independent, black-white differences in hemoglobin A1c levels: a cross-sectional analysis of 2 studiesDavid C Ziemer
Division of Endocrinology, Emory University School of Medicine, 49 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
Ann Intern Med 152:770-7. 2010..A previous study of participants with prediabetes found that hemoglobin A(1c) (HbA(1c)) levels differed between black and white participants with no differences in glucose concentration...
- Longitudinal study on pubertal insulin resistanceM I Goran
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Diabetes 50:2444-50. 2001..The significant fall in DI suggests conservation in beta-cell function or an inadequate beta-cell response to the fall in S(I). The fall in S(I) was not associated with changes in body fat, visceral fat, IGF-I, androgens, or estradiol...
- Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statementJohn M Flack
Department of Internal Medicine, Wayne State University, Detroit, Mich, USA
Hypertension 56:780-800. 2010....
- Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (INSEL) ancestry-informative marker (AIM) panelNey P C Santos
Laboratório de Genética Humana e Médica, Universidade Federal do Para, Belem, Para, Brazil
Hum Mutat 31:184-90. 2010....
- The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotypeA Gaedigk
Section of Developmental Pharmacology and Experimental Therapeutics, Children s Mercy Hospital and Clinics, Kansas City, Missouri, USA
Clin Pharmacol Ther 83:234-42. 2008..The AS tool warrants further prospective evaluation for CYP2D6 substrates and in additional ethnic populations...
- Contribution of major diseases to disparities in mortalityMitchell D Wong
Division of General Internal Medicine and Health Services Research, University of California at Los Angeles, Los Angeles 90095 1736, USA
N Engl J Med 347:1585-92. 2002..Mortality from all causes is higher for persons with fewer years of education and for blacks, but it is unknown which diseases contribute most to these disparities...
- Spectrum of heart disease and risk factors in a black urban population in South Africa (the Heart of Soweto Study): a cohort studyKaren Sliwa
Soweto Cardiovascular Research Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
Lancet 371:915-22. 2008..We aimed to investigate the clinical range of disorders related to cardiovascular disease in patients presenting for the first time to a tertiary-care centre...
- Ancestry informative marker panels for African Americans based on subsets of commercially available SNP arraysArti Tandon
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genet Epidemiol 35:80-3. 2011..The panels provide about 80% of the maximum information about African or European ancestry, even with up to 10% missing data...
- Analysis of pharmacogenetic traits in two distinct South African populationsOgechi Ikediobi
University of California, San Francisco, School of Pharmacy, Department of Clinical Pharmacy, CA 94143, USA
Hum Genomics 5:265-82. 2011..Characterising the Xhosa and CMA population frequencies of variant alleles important for drug transport and metabolism can help to establish the clinical relevance of pharmacogenetic testing in these populations...
- Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data setEtienne Patin
Institut Pasteur, Human Evolutionary Genetics, CNRS, URA3012, Paris, France
PLoS Genet 5:e1000448. 2009..An appreciation of the demographic and adaptive history of African populations with different modes of subsistence should improve our understanding of the influence of human lifestyles on genome diversity...
- Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African populationSlave Petrovski
Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina 27708, USA
AIDS 25:513-8. 2011..We investigated whether common genetic variants associate with HIV-1 susceptibility in Africans...
- On the origins and admixture of Malagasy: new evidence from high-resolution analyses of paternal and maternal lineagesSergio Tofanelli
Dipartimento di Biologia, Unità di Antropologia, Universita di Pisa, Pisa, Italy
Mol Biol Evol 26:2109-24. 2009....
- Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002Catherine C Cowie
Diabetes Epidemiology Program, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 6707 Democracy Blvd, Rm 691, MSC 5460, Bethesda, MD 20892 5460, USA
Diabetes Care 29:1263-8. 2006..The purpose of this study was to examine the prevalences of diagnosed and undiagnosed diabetes, and impaired fasting glucose (IFG) in U.S. adults during 1999-2002, and compare prevalences to those in 1988-1994...
- Complete Khoisan and Bantu genomes from southern AfricaStephan C Schuster
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA
Nature 463:943-7. 2010..Adding the described variants to current databases will facilitate inclusion of southern Africans in medical research efforts, particularly when family and medical histories can be correlated with genome-wide data...
- Glaucoma in Zulus: a population-based cross-sectional survey in a rural district in South AfricaAlan P Rotchford
International Centre for Eye Health, Institute of Ophthalmology, 11 43 Bath St, London EC1V 9EL, England
Arch Ophthalmol 120:471-8. 2002..To determine the prevalence and the main types of glaucoma in a representative adult population in rural Zululand, and to describe the distribution of glaucoma-related variables in healthy subjects and those with glaucoma...
- Characterizing the admixed African ancestry of African AmericansFouad Zakharia
Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Genome Biol 10:R141. 2009..To focus on African ancestry, we reduced the data to include only those genotypes in each African American determined statistically to be African in origin...
- Origins and genetic diversity of pygmy hunter-gatherers from Western Central AfricaPaul Verdu
Ecoanthropology and Ethnobiology, UMR, CNRS MNHN Université Paris, France
Curr Biol 19:312-8. 2009..Such an admixture pattern is consistent with the various sociocultural behaviors related to intermariages between pygmies and nonpygmies...
- Mitochondrial DNA lineages of African origin confer susceptibility to primary open-angle glaucoma in Saudi patientsKhaled K Abu-Amero
Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Mol Vis 17:1468-72. 2011..This encouraged us to extend our work and assess whether mtDNA diagnostic polymorphisms, defining geographically structured haplogroups, could be associated with the development of POAG...
- Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversityCollet Dandara
School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa
Pharmacogenomics 12:1663-70. 2011..The aim of this study was to genotype pharmacogenetically relevant variants in black South Africans, to expand the limited data set available for indigenous African populations...
- Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in AmericaRoman Kosoy
Rowe Program in Human Genetics, Department of Biochemistry, University of California Davis, Davis, California 95616, USA
Hum Mutat 30:69-78. 2009..We conclude that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations...
- Differential susceptibility to hypertension is due to selection during the out-of-Africa expansionJ Hunter Young
The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS Genet 1:e82. 2005..This differential susceptibility is likely due to our history of adaptation to climate...
- Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPsTulio C Lins
Programa de Pós Graduação em Ciências Genômicas e Biotecnologia, Universidade Catolica de Brasilia, Brasilia, DF, Brazil
Am J Hum Biol 22:187-92. 2010..085). The described multiplexed SNP panels can be useful tool for bioanthropological studies but it can be mainly valuable to control for spurious results in genetic association studies in admixed populations...
- Effects of cis and trans genetic ancestry on gene expression in African AmericansAlkes L Price
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Genet 4:e1000294. 2008..Both effects are highly significant, and we estimate that 12+/-3% of all heritable variation in human gene expression is due to cis variants...
- Prevalence of impaired glucose tolerance among children and adolescents with marked obesityRanjana Sinha
Department of Pediatrics, Yale University School of Medicine, New Haven, Conn 06520, USA
N Engl J Med 346:802-10. 2002..We determined the prevalence of impaired glucose tolerance in a multiethnic cohort of 167 obese children and adolescents...
- Meta-analysis of survival in African American and white American patients with breast cancer: ethnicity compared with socioeconomic statusLisa A Newman
University of Michigan, Ann Arbor, MI 48109, USA
J Clin Oncol 24:1342-9. 2006....
- Prevalence and pattern of hypertension in a semiurban community in NigeriaRufus A Adedoyin
Department of Medical Rehabilitation, Obafemi Awolowo University, Ile Ife, Nigeria
Eur J Cardiovasc Prev Rehabil 15:683-7. 2008..This study sought to investigate the prevalence and pattern of hypertension in the adult population living in the ancient semiurban community of Ile-Ife, southwest Nigeria...
- Predictive performance of eGFR equations in South Africans of African and Indian ancestry compared with ⁹⁹mTc-DTPA imagingNomandla D Madala
King Edward Hospital Renal Clinic, Department of Nephrology, Division of Medicine, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Int Urol Nephrol 44:847-55. 2012..212, included for MDRD-eGFR in black patients. We compared eGFR against technetium-99m-diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) imaging...
- Narrative review: ketosis-prone type 2 diabetes mellitusGuillermo E Umpierrez
Emory University School of Medicine, Atlanta, Georgia 30303, USA
Ann Intern Med 144:350-7. 2006..The underlying mechanisms for beta-cell dysfunction in ketosis-prone type 2 diabetes are not known; however, preliminary evidence suggests an increased susceptibility to glucose desensitization...
- Determinants of insulin-resistant phenotypes in normal-weight and obese Black African womenCourtney L Jennings
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Obesity (Silver Spring) 16:1602-9. 2008..Subsets of metabolically "healthy obese" and "at-risk" normal-weight individuals have been previously identified. The aim of this study was to explore the determinants of these phenotypes in black South African (SA) women...
- The Levant versus the Horn of Africa: evidence for bidirectional corridors of human migrationsJ R Luis
Department of Biological Sciences, Florida International University, Miami, 33199, USA
Am J Hum Genet 74:532-44. 2004....
- Sex differences independent of other psycho-sociodemographic factors as a predictor of body mass index in black South African adultsAnnamarie Kruger
Africa Unit for Transdisciplinary Health Research, Faculty of Health Sciences, North West University, Potchefstroom Campus, Potchefstroom, South Africa
J Health Popul Nutr 30:56-65. 2012..It is, thus, important to understand the molecular roots of sex- and gender-specific variability in distribution of BMI as this is central to the future development of treatment and prevention programmes against overweight/obesity...
- Identifying genes underlying skin pigmentation differences among human populationsSean Myles
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Hum Genet 120:613-21. 2007..Moreover, our analyses suggest that it is likely that different genes are responsible for the lighter skin pigmentation found in different non-African populations...
- The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited) -- a prospective population-based studyTherese Tillin
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom
J Am Coll Cardiol 61:1777-86. 2013..This study sought to determine whether ethnic differences in diabetes, dyslipidemia, and ectopic fat deposition account for ethnic differences in incident cardiovascular disease...
- Early emergence of ethnic differences in type 2 diabetes precursors in the UK: the Child Heart and Health Study in England (CHASE Study)Peter H Whincup
Division of Community Health Sciences, St George s, University of London, London, United Kingdom
PLoS Med 7:e1000263. 2010..We examined whether corresponding ethnic differences were apparent in childhood...
- Disparities in outcomes for African American and Latino subjects in the Flexible Initial Retrovirus Suppressive Therapies (FIRST) trialThomas P Giordano
Baylor College of Medicine, Michael E DeBakey VA Medical Center, and Thomas Street Health Center, Houston, Texas 77030, USA
AIDS Patient Care STDS 24:287-95. 2010..Efforts to promote access to HIV testing and care and to improve adherence have the potential to reduce racial/ethnic disparities in outcomes of patients with HIV infection...
- Ancestral components of admixed genomes in a Mexican cohortNicholas A Johnson
Department of Statistics, Stanford University, Stanford, California, United States of America
PLoS Genet 7:e1002410. 2011..The ability to infer precise ancestral components of admixed genomes will facilitate studies of disease-related phenotypes and will allow new insight into the adaptive and demographic history of indigenous people...
- Ketosis-prone type 2 diabetes mellitus and human herpesvirus 8 infection in sub-saharan africansEugene Sobngwi
Department of Endocrinology and Diabetes, Saint Louis University Hospital, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
JAMA 299:2770-6. 2008..Its sudden onset suggests precipitating factors...
- The prevalence of hypertension in seven populations of west African originR Cooper
Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Ill 60153, USA
Am J Public Health 87:160-8. 1997..This study was undertaken to describe the distribution of blood pressures, hypertension prevalence, and associated risk factors among seven populations of West African origin...
- Multitissue insulin resistance despite near-normoglycemic remission in Africans with ketosis-prone diabetesSimeon Pierre Choukem
Department of Diabetes and Endocrinology, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, University Paris Diderot Paris 7, Paris, France
Diabetes Care 31:2332-7. 2008..To characterize insulin action in Africans with ketosis-prone diabetes (KPD) during remission...
- Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population surveyAudrey Sabbagh
Institut de Recherche pour le Developpement, UMR 216, Paris, France
PLoS ONE 6:e18507. 2011....
- Maternal sepsis: a Scottish population-based case-control studyC D Acosta
National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
BJOG 119:474-83. 2012..To describe the risk of maternal sepsis associated with obesity and other understudied risk factors such as operative vaginal delivery...
- Metabolic syndrome, aging, physical inactivity, and incidence of type 2 diabetes in general African populationB Longo-Mbenza
Department of Internal Medicine, University of Kinshasa, DRC
Diab Vasc Dis Res 7:28-39. 2010..In conclusion, urgent prevention strategies are needed to curb the type 2 diabetes epidemic in Africa...
- Assessment of GFR by four methods in adults in Ashanti, Ghana: the need for an eGFR equation for lean African populationsJohn B Eastwood
Departments of Renal Medicine and Transplantation, St Georges, University of London, Cranmer Terrace, London SW17 0RE, UK
Nephrol Dial Transplant 25:2178-87. 2010..Equations for estimating glomerular filtration rate (GFR) have not been validated in Sub-Saharan African populations, and data on GFR are few...
- Body size and breast cancer in a black population--the Barbados National Cancer StudyBarbara Nemesure
Department of Preventive Medicine, Stony Brook University, Stony Brook, NY 11794 8036, USA
Cancer Causes Control 20:387-94. 2009..To evaluate the relationship between body size and incident breast cancer in an African-origin Caribbean population...
- Inflammation and race and gender differences in computerized tomography-measured adipose depotsLydia E Beasley
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
Obesity (Silver Spring) 17:1062-9. 2009..Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined...
- Factors influencing the vitamin D status of 10-year-old urban South African childrenMachuene A Poopedi
MRC Mineral Metabolism Research Unit and Birth to Twenty Research Programme, Department of Paediatrics and Child Health, Chris Hani Baragwanath Hospital, The University of the Witwatersrand, PO Bertsham, 2013 Johannesburg, South Africa
Public Health Nutr 14:334-9. 2011..Assessment of vitamin D status in a cohort of healthy 10-year-old urban children and the factors that influence vitamin D status in these children...
- Bone mass and bone size in pre- or early pubertal 10-year-old black and white South African children and their parentsL Vidulich
MRC Mineral Metabolism Research Unit, Department of Paediatrics, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
Calcif Tissue Int 88:281-93. 2011..Heritability was comparable between environmentally disadvantaged black and advantaged white South African children and similar to that reported for Caucasians in other parts of the world...
- Oscillating migration and the epidemics of silicosis, tuberculosis, and HIV infection in South African gold minersDavid Rees
Occupational Medicine Division, National Institute for Occupational Health, National Health Laboratory Service, Johannesburg, South Africa
Am J Ind Med 53:398-404. 2010..This is termed oscillating or circular migration. Today we have serious interrelated epidemics of silicosis, tuberculosis, and HIV infection in the gold mining industry...
- North African influences and potential bias in case-control association studies in the Spanish populationMaría Pino-Yanes
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
PLoS ONE 6:e18389. 2011..Using ancestry informative markers (AIMs), we aimed to measure the African influences in Spanish populations and to explore whether these might introduce statistical bias in population-based association studies...
- The date of interbreeding between Neandertals and modern humansSriram Sankararaman
Department of Genetics, Harvard Medical School, Boston, MA, USA
PLoS Genet 8:e1002947. 2012..This supports the recent interbreeding hypothesis and suggests that interbreeding may have occurred when modern humans carrying Upper Paleolithic technologies encountered Neandertals as they expanded out of Africa...
- Adaptive evolution of the FADS gene cluster within AfricaRasika A Mathias
Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 7:e44926. 2012....
- The effect of patients' preferences on racial differences in access to renal transplantationJ Z Ayanian
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 341:1661-9. 1999..In the United States, black patients undergo renal transplantation less often than white patients, but few studies have directly assessed the association between race and patients' preferences with respect to transplantation...
- Consistency of genome-wide associations across major ancestral groupsEvangelia E Ntzani
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, 45110 Ioannina, Greece
Hum Genet 131:1057-71. 2012....
- Reduced gluteal expression of adipogenic and lipogenic genes in Black South African women is associated with obesity-related insulin resistanceJulia H Goedecke
University of Cape Town Medical Research Council Research Unit for Exercise Science and Sports Medicine, University of Cape Town, 3rd Floor Sports Science Institute of South Africa, P O Box 115, Newlands 7725, South Africa
J Clin Endocrinol Metab 96:E2029-33. 2011..We hypothesized that this paradox may be explained, in part, by differences in the adipogenic capacity of sc adipose tissue (SAT)...
- Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan AfricansJenny Svärd
Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland
J Acquir Immune Defic Syndr 55:536-49. 2010..However, information is lacking on the impact of genetic polymorphism on this interaction...
- West African and Amerindian ancestry and risk of myocardial infarction and metabolic syndrome in the Central Valley population of Costa RicaEdward A Ruiz-Narváez
Slone Epidemiology Center, Boston University, Boston, MA, USA
Hum Genet 127:629-38. 2010..20 (1.01, 1.42). These results show that the high variability of admixture proportions in the Central Valley population offers a unique opportunity to uncover the genetic basis of ethnic differences on the risk of disease...
- Should obesity be blamed for the high prevalence rates of hypertension in black South African women?A E Schutte
School for Physiology, Nutrition and Consumer Sciences, North West University, Potchefstroom, South Africa
J Hum Hypertens 22:528-36. 2008..The results, however, suggest a link with the development of insulin resistance...
- Long-term outcome of peripartum cardiomyopathy in a population with high seropositivity for human immunodeficiency virusKaren Sliwa
Soweto Cardiovascular Research Unit, Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
Int J Cardiol 147:202-8. 2011..Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy with a high risk of mortality. The present study assessed clinical outcome and mortality over a 2-year period in an African cohort of 80 PPCM patients...
- Estimation of the multiple testing burden for genomewide association studies of nearly all common variantsItsik Pe'er
Department of Computer Science, Columbia University, New York, New York, USA
Genet Epidemiol 32:381-5. 2008..We further identify the sensitivity of the testing burden to the required significance level, with implications to staged design of association studies...
- Ethnic differences in serum lipoproteins and their determinants in South African womenJulia H Goedecke
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, 7700 South Africa
Metabolism 59:1341-50. 2010..The major determinants of serum lipids in black women were socioeconomic status and lifestyle factors, whereas in white women, S(I) and body composition most closely correlated with serum lipids...
- Diabetes and other disorders of glycemia in a rural South African community: prevalence and associated risk factorsAyesha A Motala
Department of Endocrinology, University of KwaZulu Natal, Durban, South Africa
Diabetes Care 31:1783-8. 2008..The purpose of this study was to determine the prevalence of diabetes, impaired glucose tolerance (IGT), impaired fasting glycemia (IFG), and associated risk factors in a rural South African black community...
- African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of ColombiaCandelaria Vergara
Institute for Immunological Research, University of Cartagena, Bolivar, Colombia
Hum Genet 125:565-79. 2009..Our findings indicate that genetic factors can explain the association between asthma and African ancestry and suggest that this sample is a useful resource for performing admixture mapping for asthma...
- Rationale and study design of a cross sectional study documenting the prevalence of Heart Failure amongst the minority ethnic communities in the UK: the E-ECHOES Study (Ethnic--Echocardiographic Heart of England Screening Study)Paramjit S Gill
Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
BMC Cardiovasc Disord 9:47. 2009....
- A genomewide admixture mapping panel for Hispanic/Latino populationsXianyun Mao
Department of Anthropology, The Pennsylvania State University, University Park, PA 16801, USA
Am J Hum Genet 80:1171-8. 2007..This genomewide AM panel will make it possible to apply AM approaches in many admixed populations throughout the Americas...
- Eurasian and Sub-Saharan African mitochondrial DNA haplogroup influences pseudoexfoliation glaucoma development in Saudi patientsKhaled K Abu-Amero
Ophthalmic Genetics Laboratory, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Mol Vis 17:543-7. 2011..To investigate whether different mitochondrial DNA (mtDNA) haplogroups have a role on the development of pseudoexfoliation glaucoma (PEG) in the Saudi Arab population...
- Insights into the demographic history of African Pygmies from complete mitochondrial genomesChiara Batini
Institut de Biologia Evolutiva CSIC UPF, Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
Mol Biol Evol 28:1099-110. 2011....
- Voluntary participation and informed consent to international genetic researchPatricia A Marshall
Department of Bioethics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4976, USA
Am J Public Health 96:1989-95. 2006..We compared voluntary participation and comprehension of informed consent among individuals of African ancestry enrolled in similarly designed genetic studies of hypertension in the United States and Nigeria...
- Frequency of dementia etiologies in four ethnic groupsCraig E Hou
Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
Dement Geriatr Cogn Disord 22:42-7. 2006..Research on dementia among ethnically diverse populations in the USA has focused primarily on Alzheimer disease and vascular dementia, but there are limited data on other neurodegenerative causes of dementia...
- Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in AfricaTaras K Oleksyk
Department of Biology, University of Puerto Rico at Mayaguez, Mayaguez, Puerto Rico
PLoS ONE 5:e11474. 2010..The population-specific divergence in MYH9 risk allele frequencies among the world's populations may prove important in risk assessment and public health policies to mitigate the burden of kidney disease in vulnerable populations...
- Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal statusJohn F Randolph
Clinical Centers University of Michigan, Ann Arbor, Michigan 48109, USA
J Clin Endocrinol Metab 88:1516-22. 2003..All hormone concentrations were significantly correlated with body mass index. We conclude that serum sex steroid, FSH, and SHBG levels vary by ethnicity, but are highly confounded by ethnic disparities in body size...
- The associations between socio-economic status and major depressive disorder among Blacks, Latinos, Asians and non-Hispanic Whites: findings from the Collaborative Psychiatric Epidemiology StudiesA R Gavin
School of Social Work, University of Washington, Seattle, WA 98105 6299, USA
Psychol Med 40:51-61. 2010....
- Association of weight change with ethnicity and life course socioeconomic position among Brazilian civil servantsDora Chor
Department of Epidemiology, National School of Public Health, Oswaldo Cruz Foundation, R Leopoldo Bulhoes 1480, Rio de Janeiro, Brazil
Int J Epidemiol 33:100-6. 2004..We evaluated ethnic differences in adult weight change and the role of life course SEP in those differences...
- Ethnic disparities in access to care in post-apartheid South AfricaZeida R Kon
Department of Health Management and Policy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Am J Public Health 98:2272-7. 2008..We investigated ethnic disparities in obtaining medical care among the 4 major ethnic groups (Blacks, Whites, Coloreds [i.e., those of mixed race], and Asians) in post-apartheid South Africa...
- Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescentsJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, University of California, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
Pediatrics 115:e561-5. 2005..Obesity and insulin resistance are major established risk factors for NAFLD. The role of gender, race, and ethnicity on the prevalence of fatty liver in obese children is unknown...
- Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypesAndrew E Fry
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Hum Mol Genet 18:2683-92. 2009..98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency...
- Is the current BMI obesity classification appropriate for black and white postmenopausal women?E M Evans
Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Urbana 61801, USA
Int J Obes (Lond) 30:837-43. 2006..To evaluate the relation between body fatness (%Fat) and body mass index (BMI) and to evaluate the validity of the BMI standards for obesity established by the NIH in older black and white postmenopausal women...
- Genomics Scholar ProgramRamana Madupu; Fiscal Year: 2013..During their internship at JCVI we propose to engage the Fellows in diverse research activities situated within a portfolio of research and education initiatives operated by the JCVI. ..
- RECOMBINANT DNA INVESTIGATION OF GALACTOSEMIARandall Heidenreich; Fiscal Year: 1991..Automated instruments described elsewhere in this grant will facilitate analysis of data. Several other laboratories are also engaged in molecular biology research and represent a renewing source of advisory expertise...
- WEB DUBOIS COLLECTIVE RESEARCH INSTITUTEMARGARET SPENCER; Fiscal Year: 2003..g., color prejudice, under employment) that suggest the need to essentially redefine success or productivity within minority communities constrained by unique and chronic economic, social,a nd political issues. ..
- THE ACQUISTION OF SEX-TYPES AND OTHER STEREOTYPESKENNETH MC GRAW; Fiscal Year: 1980..The saliency is apparent in the fact that children sex type occupations and activities as early as age two. An empirical assessment of the saliency of sex relative to age, race, and glasses will be obtained as part of Experiment 1...
- African-American Breast Cancer Survivor Quality of LifeKathleen Russell; Fiscal Year: 2003..Data will be analyzed using multivariate analysis of variance procedures to address differences between groups. ..
- Depression in Black and White Adolescent GirlsDebra Franko; Fiscal Year: 2002....
- Using Social Risk to Guide Coronary Heart Disease (CHD) Preventive TreatmentKevin Fiscella; Fiscal Year: 2009..Implementation of such a global risk tool could ultimately help justify implementation of more intensive behavioral interventions focusing on diet, exercise, smoking cessation and medication adherence for those at highest social risk. ..
- Randomized Control Trial of Mifepristone for FibroidsKevin Fiscella; Fiscal Year: 2004..The study may also offer valuable insight into a mechanism by which mifepristone reduces fibroid size. ..
- Do Reporting Biases Mitigate Disparity Estimates?Kevin Fiscella; Fiscal Year: 2004..abstract_text> ..
- The Impact of HMO's on DispartiesKevin Fiscella; Fiscal Year: 2004..If the study hypotheses are confirmed, the findings will underscore the need for HMOs to track and address disparities among their members if the Healthy People 2010 for the elimination of disparities is to be achieved. ..
- DATA COORDINATING CENTER FOR EARLY GLAUCOMA TRIALM Leske; Fiscal Year: 2004....
- Social Inequalities in Periodontal DiseasesLuisa Borrell; Fiscal Year: 2006..unreadable] [unreadable]..
- The Barbados Study of Ocular Conditions (BSOC)Suh Yuh Wu; Fiscal Year: 2005..The considerably high participation in the cohort (84% in BES, 85% in BISED, and 81% in BISED II), as well as the experience of the research team support the feasibility and yield of the proposed study. ..
- Determinants and Consequences of Alcohol ConsumptionFrank Sloan; Fiscal Year: 2008..abstract_text> ..
- Ethnicity, Alcohol, and Spousal ViolenceRaul Caetano; Fiscal Year: 2008..collecting data from both couple members. ..
- Brief Intervention to Reduce Injury in MinoritiesRaul Caetano; Fiscal Year: 2006....
- PRIVATE AND SOCIAL COST OF SMOKINGFrank Sloan; Fiscal Year: 2001..We will examine implications of our empirical analysis for tort claims brought against tobacco companies and the evolution of legal theories underlying tobacco tort litigation in a law review article. ..
- The Antecedents and Implications of Intergroup AnxietyE Plant; Fiscal Year: 2002..abstract_text> ..
- Visual Impairment, Treatment and Effects on the ElderlyFrank Sloan; Fiscal Year: 2008..Ten papers are anticipated for this four-year study. [unreadable] [unreadable]..
- RACIAL AND NEIGHBORHOOD DISPARITIES IN INFANT HEALTHIrma Elo; Fiscal Year: 2002..The sample composition will permit us to address explicitly the role of race in infant health, and to examine whether factors contributing to infant health are similar for low income women in all racial/ethnic groups. ..
- Alcohol Epidemiology In Hispanic National GroupsRaul Caetano; Fiscal Year: 2007..Results from this study will fill a major gap in epidemiology among U.S. Hispanics, and will have implications for the development of prevention interventions. ..
- Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 geneXingguang Luo; Fiscal Year: 2010..In a word, this study will identify some risk genes for alcohol dependence, helping us better understand the etiology of alcohol dependence and provide potential targets for new drugs. ..
- Cross Ethnic Trends In Drinking, Alcohol Use Disorders And Service UtilizationRaul Caetano; Fiscal Year: 2010..The proposed aims will cover important gaps in significant areas of alcohol epidemiology. Trends analyses covering the period under focus and contrasting Whites, Blacks and Hispanics have not been reported yet in the alcohol literature. ..
- BRCA1 TESTING IN A LARGE AFRICAN AMERICAN KINDREDAnita Kinney; Fiscal Year: 2003..abstract_text> ..
- Psychosocial Determinants of Nutrient Intake in GirlsRuth Striegel Moore; Fiscal Year: 2004..Adult weight was also measured. Results from our secondary analyses will be useful for interventions aimed at improving nutritional health. ..
- PREVENTIVE ONCOLOGY AWARDAnita Kinney; Fiscal Year: 2003..The University of Utah is a major academic institution with many distinguished scientists, and offers an excellent environment for Dr. Kinney to develop her skills and gain additional expertise to accomplish her goals. ..
- Outcome and Quality of Life after Diabetic StrokeBrett Kissela; Fiscal Year: 2007..It is the goal of the Prinicipal Investigator to become an expert in epidemiology and outcomes research and to use clinical research to improve the lives of diabetic patients with stroke. ..
- The Social Context of Disclosure and HIV Sexual Risk among Bisexual Black MenDavid Malebranche; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- The significance of racial segregation for CV diseaseMary Vaughan Sarrazin; Fiscal Year: 2007..The knowledge gained from this study about the significance of segregation as a determinant of racial disparity will be essential for designing effective strategies for eliminating disparities. [unreadable] [unreadable] [unreadable]..
- Opioid Prescribing Patterns in the U.S.Mark Pletcher; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Stress, Sleep and Emerging CVD Risk FactorsKaren Matthews; Fiscal Year: 2007..The study will provide novel data testing the relationships of daytime stressful events, SDB, and other nocturnal physiological measures with the emerging risk factors and subclinical CVD measured in HeartSCORE. [unreadable] [unreadable]..
- Race & Breast Cancer Estrogen Receptor Status: Impact of Class and Missing DataNancy Krieger; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- A Women's-Only Phase II Cardiac Rehabilitation ProgramTHERESA BECKIE; Fiscal Year: 2007..The findings have the potential to influence a paradigm shift for clinical practice and lead to important policy changes. ..
- Does Marriage in Sweden Affect Child and Adult Outcomes?DONNA GINTHER; Fiscal Year: 2007..in policy? 5) Does the type of selection into marriage (self-selection compared with response to policy change) matter for outcomes? 6) Does the duration of marriage affect child and adult outcomes? [unreadable] [unreadable] [unreadable]..
- Understanding Reversed Race/Ethnic Associations with Cancer Screening TestsWilliam Rakowski; Fiscal Year: 2008..Fifth, it will be possible to look for trends over time in the presence of reversals of association for repeat screening. [unreadable] [unreadable] [unreadable]..
- Injury from Sexual Assault: Addressing Health DisparityMarilyn S Sommers; Fiscal Year: 2010..Public Health Relevance: Violence against women is a silent epidemic. The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
- Risk of Adverse Outcomes after Spinal Cord Injury: A Longitudinal StudyJames S Krause; Fiscal Year: 2010..abstract_text> ..
- ACTIVITY AND OBESITY IN US BLACK & NIGERIAN WOMENAmy Luke; Fiscal Year: 2004..The proposed study will not use an ecologic design, since conclusions will be based relationships defined among individuals, not the comparison of group means. ..
- Breast Cancer After The Women?s Health Initiative Study: Declining Incidence?Nancy Krieger; Fiscal Year: 2008..The knowledge gained will lead to new insights about the causes of breast cancer and ways its incidence can be reduced. [unreadable] [unreadable] [unreadable]..
- Defining the Clinical Significance of HbA1c Prior to the Onset of DiabetesElizabeth Selvin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Epidemiology of Regulatory T Cells in Pregnancy and Childhood Atopic DiseasesGanesa Wegienka; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- A Pilot Smoking Cessation Study for Newly Diagnosed Lung Cancer PatientsElyse Park; Fiscal Year: 2008..We propose to assess the efficacy and potential feasibility of a combined behavioral and pharmacological treatment program that is integrated into the thoracic oncology setting. [unreadable] [unreadable] [unreadable]..
- Pittsburgh Mind-Body Center-IIKaren Matthews; Fiscal Year: 2008..Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible. ..
- Alcohol-Metabolizing Gene Variation, Lipids, Hemostatic Factors and CVDKelly Volcik; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Racial Discrimination and Risk of Chronic DiseaseNancy Krieger; Fiscal Year: 2010....
- Antioxidant nutrients and Oxidative DNA Damage in Afric*Jessie Satia; Fiscal Year: 2005..In addition, this work would potentially provide investigators with a validated instrument for assessing antioxidant nutrient exposure in population-based studies in the U.S. ..
- Metabolic Syndrome and Cognitive ImpairmentKristine Yaffe; Fiscal Year: 2005..If elders with metabolic syndrome have increased risk of developing cognitive impairment, this would have important clinical and public health significance. ..
- Etiology of Geographic and Racial Differences in StrokeGeorge Howard; Fiscal Year: 2001....
- Socioeconomic Trends in Breast Cancer IncidenceNancy Krieger; Fiscal Year: 2005..Results of this investigation will provide new insights into social determinants of and secular changes in breast cancer incidence, with implications for breast cancer surveillance, screening and control. ..
- Diverse Screening Histories--Persons, Groups, BehaviorsWilliam Rakowski; Fiscal Year: 2005..Mentored junior investigators will participate in these activities, as they develop their own programs of research. ..
- AREA-BASED SOCIOECONOMIC MEASURES FOR HEALTH DATANancy Krieger; Fiscal Year: 2003....
- CANCER COURSES FOR NURSES WORKING WITH MINORITY GROUPSSandra Millon Underwood; Fiscal Year: 2004..to be tested will focus on the degree to which the program facilitates the integration of didactic content, thoughtful discussions, clinical/laboratory experiences, related literature, evidence-based information obtained from the ..
- Diet, Colon Cancer, and Cancer CommunicationsJessie Satia; Fiscal Year: 2005..Obtaining this award will greatly broaden and strengthen the candidate's focus on cancer prevention and control. ..
- Analysis of the Cardiac Access StudyThomas LaVeist; Fiscal Year: 2003..abstract_text> ..
- PREVALENCE AND IMPACT OF GLAUCOMA AMONG THE VERY ELDERLYDavid Friedman; Fiscal Year: 2003..Finally, the interactions between comorbidities (including cognitive deficits) and visual field loss will be explored. ..
- ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMENKristine Yaffe; Fiscal Year: 2002..This award will foster the applicant's development towards becoming an independent investigator in aging research. ..
- A PROSPECTIVE STUDY OF RISK OF MORTALITY AFTER SCIJames Krause; Fiscal Year: 2002..Risk profiles will be generated to identify individuals at greatest risk for early mortality. Separate analyses and risk profiles will be generated based on injury severity, gender and race/ethnicity. ..
- Genetics of Lipoproteins in Afro-Caribbean FamiliesIva Miljkovic Gacic; Fiscal Year: 2007..Our long-term goal is to dissect the genetic architecture of traditional and nuclear magnetic spectroscopy (NMR) measured lipoprotein phenotypes in extended, multi-generational families of African heritage. [unreadable] [unreadable]..
- Geocoding, Census Data & Social Disparities in HealthNancy Krieger; Fiscal Year: 2005....
- Sex Hormones, Related Polymorphisms & Cognitive DeclineKristine Yaffe; Fiscal Year: 2006..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
- Dietary Supplements and Lung & Colorectal Cancer RiskJessie Satia; Fiscal Year: 2006..abstract_text> ..
- Impact of Certificate of Need on the Use of Revascularization for AMIMary Vaughan Sarrazin; Fiscal Year: 2006..g., revascularization, mortality) and Cox regression with stratification for time-to-event outcomes (e.g., time to readmission). [unreadable] [unreadable]..
- Serum Protemic Patterns Associated With AtherosclerosisMark Pletcher; Fiscal Year: 2006....
- Persistence and Desistence in Heavy Drinking and ViolenceHelene R White; Fiscal Year: 2010..Within a 2-year period, we will be able to make a significant contribution to the scholarly literature and provide data to be used in the development of targeted pre,vention programs. ..
- BIOLOGICAL BASIS OF THE PERIMENOPAUSEDAVID SEIFER; Fiscal Year: 2002....
- Chronic Kidney Disease Morbidity, Mortality & PredictorsStephen Derose; Fiscal Year: 2005..Researchers may use this information to generate hypotheses and plan studies that include subjects with CKD. ..
- Autonomic Function in Insulin Resistance and DiabetesMercedes Carnethon; Fiscal Year: 2005..abstract_text> ..
- MH Services & Predictors of Learning in Urban SchoolsMarc Atkins; Fiscal Year: 2009..abstract_text> ..
- BIOPTERIN, CATECHOLAMINES, & NO IN REGULATING APOPTOSISRobert Levine; Fiscal Year: 2002..These studies may will reveal novel apoptotic regulatory mechanisms and provide new avenues for therapeutic approaches to promote neuronal survival and prevent debilitating neurological diseases, such as Parkinson's disease. ..
- Bone Health in Pediatric Crohn Disease: A Low Magnitude Mechanical Stimulus TrialMARY BETH LEONARD; Fiscal Year: 2010..The NIH Osteoporosis Consensus Statement called for studies to identify interventions that promote bone health in children at risk. LMMS may provide a safe and effective treatment for myriad chronic pediatric diseases. ..
- HIV, Race and Survival in the Highly Active Therapy EraThomas Giordano; Fiscal Year: 2007..unreadable] [unreadable]..
- Neurobiologic Study of Psychological Distress & DementiaRobert S Wilson; Fiscal Year: 2010....
- Structural Bone Disease in Chronic Renal InsufficiencyMary Leonard; Fiscal Year: 2007..Accurate characterization of bone structure in CRI is necessary to identify risk factors for fragility, and to evaluate potential therapies. ..
- Vascular Depression and Function in Older LatinosHECTOR GONZALEZ; Fiscal Year: 2007..abstract_text> ..
- Incarceration Effects on Prevention of Drug Use, STI-HIV and RecidivismSeijeoung Kim; Fiscal Year: 2008..Improving the health of this population-at-risk will help protect the health and well-being of the public. [unreadable] [unreadable] [unreadable]..
- Changes in Alcohol Availability and HIV RatesRichard Scribner; Fiscal Year: 2009..Study Hypothesis 2: Changes in alcohol outlet density at the census tract level will explain a significant amount of the trend in HIV/AIDS and gonorrhea rates over the study period. ..
- Resistant E.coli in Humans and PoultryJames Johnson; Fiscal Year: 2005..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
- Epidemiology of Subclinical Atherosclerosis in SLELisabeth Scalzi; Fiscal Year: 2008..SLE, an inflammatory and immune-dysregulated disease, may provide an ideal model of CVD. ..
- Pathways From Subtypes of Aggression to Substance UsePaula Fite; Fiscal Year: 2007....
- Hypertension PharmacogeneticsJulie Johnson; Fiscal Year: 2006..The proposed studies should add substantial new information about antihypertensive pharmacogenetics, and could influence how antihypertensive medications are prescribed in the future. ..
- Progression of sub-clinical AtherosclerosisJoseph Polak; Fiscal Year: 2009..This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers. ..
- College Alcohol Environmental and College DrinkingRichard Scribner; Fiscal Year: 2007..The project represents an initial effort at understanding the relative importance of campus/community level factors in impacting college drinking outcomes. Such knowledge is essential for the development of effective prevention efforts. ..