african continental ancestry group

Summary

Summary: Individuals whose ancestral origins are in the continent of Africa.

Top Publications

  1. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
  2. pmc Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumann Strasse 21 22, 10117 Berlin, Germany
    Genetics 164:1567-87. 2003
  3. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
  4. pmc Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
    Alkes L Price
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    PLoS Genet 5:e1000519. 2009
  5. pmc Genome-wide patterns of population structure and admixture in West Africans and African Americans
    Katarzyna Bryc
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 107:786-91. 2010
  6. pmc Assessing the evolutionary impact of amino acid mutations in the human genome
    Adam R Boyko
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA
    PLoS Genet 4:e1000083. 2008
  7. ncbi SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
  8. ncbi Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    Jonathan Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines, Dallas, Texas 75390 9046, USA
    Nat Genet 37:161-5. 2005
  9. pmc The history of African gene flow into Southern Europeans, Levantines, and Jews
    Priya Moorjani
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1001373. 2011
  10. pmc Epidemiology of basal-like breast cancer
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 109:123-39. 2008

Research Grants

  1. Genomics Scholar Program
    Ramana Madupu; Fiscal Year: 2013
  2. RECOMBINANT DNA INVESTIGATION OF GALACTOSEMIA
    Randall Heidenreich; Fiscal Year: 1991
  3. WEB DUBOIS COLLECTIVE RESEARCH INSTITUTE
    MARGARET SPENCER; Fiscal Year: 2003
  4. THE ACQUISTION OF SEX-TYPES AND OTHER STEREOTYPES
    KENNETH MC GRAW; Fiscal Year: 1980
  5. African-American Breast Cancer Survivor Quality of Life
    Kathleen Russell; Fiscal Year: 2003
  6. Depression in Black and White Adolescent Girls
    Debra Franko; Fiscal Year: 2002
  7. Using Social Risk to Guide Coronary Heart Disease (CHD) Preventive Treatment
    Kevin Fiscella; Fiscal Year: 2009
  8. Randomized Control Trial of Mifepristone for Fibroids
    Kevin Fiscella; Fiscal Year: 2004
  9. Do Reporting Biases Mitigate Disparity Estimates?
    Kevin Fiscella; Fiscal Year: 2004
  10. The Impact of HMO's on Disparties
    Kevin Fiscella; Fiscal Year: 2004

Detail Information

Publications367 found, 100 shown here

  1. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
    ..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
  2. pmc Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumann Strasse 21 22, 10117 Berlin, Germany
    Genetics 164:1567-87. 2003
    ..The methods are implemented in a program, structure, version 2.0, which is available at http://pritch.bsd.uchicago.edu...
  3. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
    ..This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies...
  4. pmc Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
    Alkes L Price
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    PLoS Genet 5:e1000519. 2009
    ....
  5. pmc Genome-wide patterns of population structure and admixture in West Africans and African Americans
    Katarzyna Bryc
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 107:786-91. 2010
    ....
  6. pmc Assessing the evolutionary impact of amino acid mutations in the human genome
    Adam R Boyko
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA
    PLoS Genet 4:e1000083. 2008
    ....
  7. ncbi SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
    ....
  8. ncbi Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    Jonathan Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines, Dallas, Texas 75390 9046, USA
    Nat Genet 37:161-5. 2005
    ..1%) and were associated with a 40% reduction in plasma levels of LDL cholesterol. These data indicate that common sequence variations have large effects on plasma cholesterol levels in selected populations...
  9. pmc The history of African gene flow into Southern Europeans, Levantines, and Jews
    Priya Moorjani
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1001373. 2011
    ..For the Jewish admixture, we obtain an average estimated date of about 72 generations. This may reflect descent of these groups from a common ancestral population that already had some African ancestry prior to the Jewish Diasporas...
  10. pmc Epidemiology of basal-like breast cancer
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 109:123-39. 2008
    ..Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity...
  11. pmc Hunter-gatherer genomic diversity suggests a southern African origin for modern humans
    Brenna M Henn
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:5154-62. 2011
    ..However, African hunter-gatherer populations continue to maintain the highest levels of genetic diversity in the world...
  12. ncbi Genome-wide analysis of the structure of the South African Coloured Population in the Western Cape
    Erika de Wit
    Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology, DST NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, 7505, South Africa
    Hum Genet 128:145-53. 2010
    ..This is consistent with historical data. While of great historical and genealogical interest, this information is also essential for future admixture mapping of disease genes in this population...
  13. ncbi Skin pigmentation, biogeographical ancestry and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
    Hum Genet 112:387-99. 2003
    ..The implications and applications of ancestry estimates in biomedical research are discussed...
  14. pmc Genotype-imputation accuracy across worldwide human populations
    Lucy Huang
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Hum Genet 84:235-50. 2009
    ..Our results can serve as a guide for selecting appropriate reference panels for imputation-based GWA analysis in diverse populations...
  15. ncbi Whole-mtDNA genome sequence analysis of ancient African lineages
    Mary Katherine Gonder
    Department of Biology, University of Maryland, MD, USA
    Mol Biol Evol 24:757-68. 2007
    ..We propose that a large and diverse human population has persisted in eastern Africa and that eastern Africa may have been an ancient source of dispersion of modern humans both within and outside of Africa...
  16. ncbi Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model for use in epidemiologic surveys
    Shumei S Sun
    Lifespan Research Center, Department of Community Health, Wright State University School of Medicine, Dayton, OH 45420, USA
    Am J Clin Nutr 77:331-40. 2003
    ..Previous studies to develop and validate bioelectrical impedance analysis (BIA) equations to predict body composition were limited by small sample sizes, sex specificity, and reliance on reference methods that use a 2-component model...
  17. pmc Methodological challenges of genome-wide association analysis in Africa
    Yik Ying Teo
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Genet 11:149-60. 2010
    ..We review the methodological challenges and consider how GWA studies in Africa will be transformed by new approaches in statistical imputation and large-scale genome sequencing...
  18. pmc An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels
    Rami Nassir
    Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, University of California Davis, Davis, CA 95616, USA
    BMC Genet 10:39. 2009
    ..Previously, we described a panel of 128 SNP AIMs that were designed as a tool for ascertaining the origins of subjects from Europe, Sub-Saharan Africa, Americas, and East Asia...
  19. pmc Ethnic and gender differences in physical activity levels among 9-10-year-old children of white European, South Asian and African-Caribbean origin: the Child Heart Health Study in England (CHASE Study)
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London, UK
    Int J Epidemiol 38:1082-93. 2009
    ..We made objective measurements of physical activity in 9-10-year-old British children of South Asian, black African-Caribbean and white European origin...
  20. ncbi Inferring ancestral origin using a single multiplex assay of ancestry-informative marker SNPs
    C Phillips
    Forensic Genetics Department, University of Santiago de Compostela, 15782, and Centro Nacional de Genotipado CeGen, Hospital Clinico Universitario, 15706 Galicia, Spain
    Forensic Sci Int Genet 1:273-80. 2007
    ..This study shows that by choosing SNPs exhibiting marked allele frequency differences between population-groups a practical forensic test for assigning the most likely ancestry can be achieved from a single multiplexed assay...
  21. ncbi The emergence of cardiovascular disease during urbanisation of Africans
    H H Vorster
    Faculty of Health Sciences, Potchefstroomse Universiteit vir Christelike Hoër Onderwys, South Africa
    Public Health Nutr 5:239-43. 2002
    ....
  22. pmc Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry
    Dezheng Huo
    Department of Health Studies, University of Chicago, 5841 South Maryland Avenue, MC 2007, Chicago, IL 60637, USA
    Carcinogenesis 33:835-40. 2012
    ..Further fine-mapping studies in women of African ancestry will be needed to reveal additional and causal variants for breast cancer...
  23. ncbi The fine-scale structure of recombination rate variation in the human genome
    Gilean A T McVean
    Department of Statistics, University of Oxford, Oxford OX1 3TG, UK
    Science 304:581-4. 2004
    ..We demonstrate that recombination hotspots are a ubiquitous feature of the human genome, occurring on average every 200 kilobases or less, but recombination occurs preferentially outside genes...
  24. pmc Geographic patterns of genome admixture in Latin American Mestizos
    Sijia Wang
    The Galton Laboratory, Department of Biology, University College London, London, United Kingdom
    PLoS Genet 4:e1000037. 2008
    ..Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region...
  25. pmc The prevalence of metabolic syndrome and determination of the optimal waist circumference cutoff points in a rural South african community
    Ayesha A Motala
    Department of Diabetes and Endocrinology, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa
    Diabetes Care 34:1032-7. 2011
    ..To determine the prevalence of metabolic syndrome and to define optimal ethnic-specific waist-circumference cutoff points in a rural South African black community...
  26. ncbi Glucose-independent, black-white differences in hemoglobin A1c levels: a cross-sectional analysis of 2 studies
    David C Ziemer
    Division of Endocrinology, Emory University School of Medicine, 49 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
    Ann Intern Med 152:770-7. 2010
    ..A previous study of participants with prediabetes found that hemoglobin A(1c) (HbA(1c)) levels differed between black and white participants with no differences in glucose concentration...
  27. ncbi Longitudinal study on pubertal insulin resistance
    M I Goran
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 50:2444-50. 2001
    ..The significant fall in DI suggests conservation in beta-cell function or an inadequate beta-cell response to the fall in S(I). The fall in S(I) was not associated with changes in body fat, visceral fat, IGF-I, androgens, or estradiol...
  28. ncbi Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement
    John M Flack
    Department of Internal Medicine, Wayne State University, Detroit, Mich, USA
    Hypertension 56:780-800. 2010
    ....
  29. ncbi Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (INSEL) ancestry-informative marker (AIM) panel
    Ney P C Santos
    Laboratório de Genética Humana e Médica, Universidade Federal do Para, Belem, Para, Brazil
    Hum Mutat 31:184-90. 2010
    ....
  30. ncbi The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype
    A Gaedigk
    Section of Developmental Pharmacology and Experimental Therapeutics, Children s Mercy Hospital and Clinics, Kansas City, Missouri, USA
    Clin Pharmacol Ther 83:234-42. 2008
    ..The AS tool warrants further prospective evaluation for CYP2D6 substrates and in additional ethnic populations...
  31. ncbi Contribution of major diseases to disparities in mortality
    Mitchell D Wong
    Division of General Internal Medicine and Health Services Research, University of California at Los Angeles, Los Angeles 90095 1736, USA
    N Engl J Med 347:1585-92. 2002
    ..Mortality from all causes is higher for persons with fewer years of education and for blacks, but it is unknown which diseases contribute most to these disparities...
  32. ncbi Spectrum of heart disease and risk factors in a black urban population in South Africa (the Heart of Soweto Study): a cohort study
    Karen Sliwa
    Soweto Cardiovascular Research Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Lancet 371:915-22. 2008
    ..We aimed to investigate the clinical range of disorders related to cardiovascular disease in patients presenting for the first time to a tertiary-care centre...
  33. ncbi Ancestry informative marker panels for African Americans based on subsets of commercially available SNP arrays
    Arti Tandon
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 35:80-3. 2011
    ..The panels provide about 80% of the maximum information about African or European ancestry, even with up to 10% missing data...
  34. pmc Analysis of pharmacogenetic traits in two distinct South African populations
    Ogechi Ikediobi
    University of California, San Francisco, School of Pharmacy, Department of Clinical Pharmacy, CA 94143, USA
    Hum Genomics 5:265-82. 2011
    ..Characterising the Xhosa and CMA population frequencies of variant alleles important for drug transport and metabolism can help to establish the clinical relevance of pharmacogenetic testing in these populations...
  35. pmc Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set
    Etienne Patin
    Institut Pasteur, Human Evolutionary Genetics, CNRS, URA3012, Paris, France
    PLoS Genet 5:e1000448. 2009
    ..An appreciation of the demographic and adaptive history of African populations with different modes of subsistence should improve our understanding of the influence of human lifestyles on genome diversity...
  36. pmc Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population
    Slave Petrovski
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina 27708, USA
    AIDS 25:513-8. 2011
    ..We investigated whether common genetic variants associate with HIV-1 susceptibility in Africans...
  37. ncbi On the origins and admixture of Malagasy: new evidence from high-resolution analyses of paternal and maternal lineages
    Sergio Tofanelli
    Dipartimento di Biologia, Unità di Antropologia, Universita di Pisa, Pisa, Italy
    Mol Biol Evol 26:2109-24. 2009
    ....
  38. ncbi Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002
    Catherine C Cowie
    Diabetes Epidemiology Program, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 6707 Democracy Blvd, Rm 691, MSC 5460, Bethesda, MD 20892 5460, USA
    Diabetes Care 29:1263-8. 2006
    ..The purpose of this study was to examine the prevalences of diagnosed and undiagnosed diabetes, and impaired fasting glucose (IFG) in U.S. adults during 1999-2002, and compare prevalences to those in 1988-1994...
  39. pmc Complete Khoisan and Bantu genomes from southern Africa
    Stephan C Schuster
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA
    Nature 463:943-7. 2010
    ..Adding the described variants to current databases will facilitate inclusion of southern Africans in medical research efforts, particularly when family and medical histories can be correlated with genome-wide data...
  40. ncbi Glaucoma in Zulus: a population-based cross-sectional survey in a rural district in South Africa
    Alan P Rotchford
    International Centre for Eye Health, Institute of Ophthalmology, 11 43 Bath St, London EC1V 9EL, England
    Arch Ophthalmol 120:471-8. 2002
    ..To determine the prevalence and the main types of glaucoma in a representative adult population in rural Zululand, and to describe the distribution of glaucoma-related variables in healthy subjects and those with glaucoma...
  41. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
    ..To focus on African ancestry, we reduced the data to include only those genotypes in each African American determined statistically to be African in origin...
  42. ncbi Origins and genetic diversity of pygmy hunter-gatherers from Western Central Africa
    Paul Verdu
    Ecoanthropology and Ethnobiology, UMR, CNRS MNHN Université Paris, France
    Curr Biol 19:312-8. 2009
    ..Such an admixture pattern is consistent with the various sociocultural behaviors related to intermariages between pygmies and nonpygmies...
  43. pmc Mitochondrial DNA lineages of African origin confer susceptibility to primary open-angle glaucoma in Saudi patients
    Khaled K Abu-Amero
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Mol Vis 17:1468-72. 2011
    ..This encouraged us to extend our work and assess whether mtDNA diagnostic polymorphisms, defining geographically structured haplogroups, could be associated with the development of POAG...
  44. ncbi Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity
    Collet Dandara
    School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa
    Pharmacogenomics 12:1663-70. 2011
    ..The aim of this study was to genotype pharmacogenetically relevant variants in black South Africans, to expand the limited data set available for indigenous African populations...
  45. pmc Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America
    Roman Kosoy
    Rowe Program in Human Genetics, Department of Biochemistry, University of California Davis, Davis, California 95616, USA
    Hum Mutat 30:69-78. 2009
    ..We conclude that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations...
  46. pmc Differential susceptibility to hypertension is due to selection during the out-of-Africa expansion
    J Hunter Young
    The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Genet 1:e82. 2005
    ..This differential susceptibility is likely due to our history of adaptation to climate...
  47. ncbi Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs
    Tulio C Lins
    Programa de Pós Graduação em Ciências Genômicas e Biotecnologia, Universidade Catolica de Brasilia, Brasilia, DF, Brazil
    Am J Hum Biol 22:187-92. 2010
    ..085). The described multiplexed SNP panels can be useful tool for bioanthropological studies but it can be mainly valuable to control for spurious results in genetic association studies in admixed populations...
  48. pmc Effects of cis and trans genetic ancestry on gene expression in African Americans
    Alkes L Price
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000294. 2008
    ..Both effects are highly significant, and we estimate that 12+/-3% of all heritable variation in human gene expression is due to cis variants...
  49. ncbi Prevalence of impaired glucose tolerance among children and adolescents with marked obesity
    Ranjana Sinha
    Department of Pediatrics, Yale University School of Medicine, New Haven, Conn 06520, USA
    N Engl J Med 346:802-10. 2002
    ..We determined the prevalence of impaired glucose tolerance in a multiethnic cohort of 167 obese children and adolescents...
  50. ncbi Meta-analysis of survival in African American and white American patients with breast cancer: ethnicity compared with socioeconomic status
    Lisa A Newman
    University of Michigan, Ann Arbor, MI 48109, USA
    J Clin Oncol 24:1342-9. 2006
    ....
  51. ncbi Prevalence and pattern of hypertension in a semiurban community in Nigeria
    Rufus A Adedoyin
    Department of Medical Rehabilitation, Obafemi Awolowo University, Ile Ife, Nigeria
    Eur J Cardiovasc Prev Rehabil 15:683-7. 2008
    ..This study sought to investigate the prevalence and pattern of hypertension in the adult population living in the ancient semiurban community of Ile-Ife, southwest Nigeria...
  52. ncbi Predictive performance of eGFR equations in South Africans of African and Indian ancestry compared with ⁹⁹mTc-DTPA imaging
    Nomandla D Madala
    King Edward Hospital Renal Clinic, Department of Nephrology, Division of Medicine, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Int Urol Nephrol 44:847-55. 2012
    ..212, included for MDRD-eGFR in black patients. We compared eGFR against technetium-99m-diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) imaging...
  53. ncbi Narrative review: ketosis-prone type 2 diabetes mellitus
    Guillermo E Umpierrez
    Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Ann Intern Med 144:350-7. 2006
    ..The underlying mechanisms for beta-cell dysfunction in ketosis-prone type 2 diabetes are not known; however, preliminary evidence suggests an increased susceptibility to glucose desensitization...
  54. ncbi Determinants of insulin-resistant phenotypes in normal-weight and obese Black African women
    Courtney L Jennings
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Obesity (Silver Spring) 16:1602-9. 2008
    ..Subsets of metabolically "healthy obese" and "at-risk" normal-weight individuals have been previously identified. The aim of this study was to explore the determinants of these phenotypes in black South African (SA) women...
  55. pmc The Levant versus the Horn of Africa: evidence for bidirectional corridors of human migrations
    J R Luis
    Department of Biological Sciences, Florida International University, Miami, 33199, USA
    Am J Hum Genet 74:532-44. 2004
    ....
  56. pmc Sex differences independent of other psycho-sociodemographic factors as a predictor of body mass index in black South African adults
    Annamarie Kruger
    Africa Unit for Transdisciplinary Health Research, Faculty of Health Sciences, North West University, Potchefstroom Campus, Potchefstroom, South Africa
    J Health Popul Nutr 30:56-65. 2012
    ..It is, thus, important to understand the molecular roots of sex- and gender-specific variability in distribution of BMI as this is central to the future development of treatment and prevention programmes against overweight/obesity...
  57. ncbi Identifying genes underlying skin pigmentation differences among human populations
    Sean Myles
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Hum Genet 120:613-21. 2007
    ..Moreover, our analyses suggest that it is likely that different genes are responsible for the lighter skin pigmentation found in different non-African populations...
  58. pmc The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited) -- a prospective population-based study
    Therese Tillin
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 61:1777-86. 2013
    ..This study sought to determine whether ethnic differences in diabetes, dyslipidemia, and ectopic fat deposition account for ethnic differences in incident cardiovascular disease...
  59. pmc Early emergence of ethnic differences in type 2 diabetes precursors in the UK: the Child Heart and Health Study in England (CHASE Study)
    Peter H Whincup
    Division of Community Health Sciences, St George s, University of London, London, United Kingdom
    PLoS Med 7:e1000263. 2010
    ..We examined whether corresponding ethnic differences were apparent in childhood...
  60. pmc Disparities in outcomes for African American and Latino subjects in the Flexible Initial Retrovirus Suppressive Therapies (FIRST) trial
    Thomas P Giordano
    Baylor College of Medicine, Michael E DeBakey VA Medical Center, and Thomas Street Health Center, Houston, Texas 77030, USA
    AIDS Patient Care STDS 24:287-95. 2010
    ..Efforts to promote access to HIV testing and care and to improve adherence have the potential to reduce racial/ethnic disparities in outcomes of patients with HIV infection...
  61. pmc Ancestral components of admixed genomes in a Mexican cohort
    Nicholas A Johnson
    Department of Statistics, Stanford University, Stanford, California, United States of America
    PLoS Genet 7:e1002410. 2011
    ..The ability to infer precise ancestral components of admixed genomes will facilitate studies of disease-related phenotypes and will allow new insight into the adaptive and demographic history of indigenous people...
  62. ncbi Ketosis-prone type 2 diabetes mellitus and human herpesvirus 8 infection in sub-saharan africans
    Eugene Sobngwi
    Department of Endocrinology and Diabetes, Saint Louis University Hospital, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    JAMA 299:2770-6. 2008
    ..Its sudden onset suggests precipitating factors...
  63. pmc The prevalence of hypertension in seven populations of west African origin
    R Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Ill 60153, USA
    Am J Public Health 87:160-8. 1997
    ..This study was undertaken to describe the distribution of blood pressures, hypertension prevalence, and associated risk factors among seven populations of West African origin...
  64. pmc Multitissue insulin resistance despite near-normoglycemic remission in Africans with ketosis-prone diabetes
    Simeon Pierre Choukem
    Department of Diabetes and Endocrinology, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, University Paris Diderot Paris 7, Paris, France
    Diabetes Care 31:2332-7. 2008
    ..To characterize insulin action in Africans with ketosis-prone diabetes (KPD) during remission...
  65. pmc Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey
    Audrey Sabbagh
    Institut de Recherche pour le Developpement, UMR 216, Paris, France
    PLoS ONE 6:e18507. 2011
    ....
  66. pmc Maternal sepsis: a Scottish population-based case-control study
    C D Acosta
    National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
    BJOG 119:474-83. 2012
    ..To describe the risk of maternal sepsis associated with obesity and other understudied risk factors such as operative vaginal delivery...
  67. ncbi Metabolic syndrome, aging, physical inactivity, and incidence of type 2 diabetes in general African population
    B Longo-Mbenza
    Department of Internal Medicine, University of Kinshasa, DRC
    Diab Vasc Dis Res 7:28-39. 2010
    ..In conclusion, urgent prevention strategies are needed to curb the type 2 diabetes epidemic in Africa...
  68. pmc Assessment of GFR by four methods in adults in Ashanti, Ghana: the need for an eGFR equation for lean African populations
    John B Eastwood
    Departments of Renal Medicine and Transplantation, St Georges, University of London, Cranmer Terrace, London SW17 0RE, UK
    Nephrol Dial Transplant 25:2178-87. 2010
    ..Equations for estimating glomerular filtration rate (GFR) have not been validated in Sub-Saharan African populations, and data on GFR are few...
  69. pmc Body size and breast cancer in a black population--the Barbados National Cancer Study
    Barbara Nemesure
    Department of Preventive Medicine, Stony Brook University, Stony Brook, NY 11794 8036, USA
    Cancer Causes Control 20:387-94. 2009
    ..To evaluate the relationship between body size and incident breast cancer in an African-origin Caribbean population...
  70. pmc Inflammation and race and gender differences in computerized tomography-measured adipose depots
    Lydia E Beasley
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 17:1062-9. 2009
    ..Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined...
  71. ncbi Factors influencing the vitamin D status of 10-year-old urban South African children
    Machuene A Poopedi
    MRC Mineral Metabolism Research Unit and Birth to Twenty Research Programme, Department of Paediatrics and Child Health, Chris Hani Baragwanath Hospital, The University of the Witwatersrand, PO Bertsham, 2013 Johannesburg, South Africa
    Public Health Nutr 14:334-9. 2011
    ..Assessment of vitamin D status in a cohort of healthy 10-year-old urban children and the factors that influence vitamin D status in these children...
  72. ncbi Bone mass and bone size in pre- or early pubertal 10-year-old black and white South African children and their parents
    L Vidulich
    MRC Mineral Metabolism Research Unit, Department of Paediatrics, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Calcif Tissue Int 88:281-93. 2011
    ..Heritability was comparable between environmentally disadvantaged black and advantaged white South African children and similar to that reported for Caucasians in other parts of the world...
  73. ncbi Oscillating migration and the epidemics of silicosis, tuberculosis, and HIV infection in South African gold miners
    David Rees
    Occupational Medicine Division, National Institute for Occupational Health, National Health Laboratory Service, Johannesburg, South Africa
    Am J Ind Med 53:398-404. 2010
    ..This is termed oscillating or circular migration. Today we have serious interrelated epidemics of silicosis, tuberculosis, and HIV infection in the gold mining industry...
  74. pmc North African influences and potential bias in case-control association studies in the Spanish population
    María Pino-Yanes
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 6:e18389. 2011
    ..Using ancestry informative markers (AIMs), we aimed to measure the African influences in Spanish populations and to explore whether these might introduce statistical bias in population-based association studies...
  75. pmc The date of interbreeding between Neandertals and modern humans
    Sriram Sankararaman
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 8:e1002947. 2012
    ..This supports the recent interbreeding hypothesis and suggests that interbreeding may have occurred when modern humans carrying Upper Paleolithic technologies encountered Neandertals as they expanded out of Africa...
  76. pmc Adaptive evolution of the FADS gene cluster within Africa
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e44926. 2012
    ....
  77. ncbi The effect of patients' preferences on racial differences in access to renal transplantation
    J Z Ayanian
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 341:1661-9. 1999
    ..In the United States, black patients undergo renal transplantation less often than white patients, but few studies have directly assessed the association between race and patients' preferences with respect to transplantation...
  78. ncbi Consistency of genome-wide associations across major ancestral groups
    Evangelia E Ntzani
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, 45110 Ioannina, Greece
    Hum Genet 131:1057-71. 2012
    ....
  79. pmc Reduced gluteal expression of adipogenic and lipogenic genes in Black South African women is associated with obesity-related insulin resistance
    Julia H Goedecke
    University of Cape Town Medical Research Council Research Unit for Exercise Science and Sports Medicine, University of Cape Town, 3rd Floor Sports Science Institute of South Africa, P O Box 115, Newlands 7725, South Africa
    J Clin Endocrinol Metab 96:E2029-33. 2011
    ..We hypothesized that this paradox may be explained, in part, by differences in the adipogenic capacity of sc adipose tissue (SAT)...
  80. ncbi Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans
    Jenny Svärd
    Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland
    J Acquir Immune Defic Syndr 55:536-49. 2010
    ..However, information is lacking on the impact of genetic polymorphism on this interaction...
  81. ncbi West African and Amerindian ancestry and risk of myocardial infarction and metabolic syndrome in the Central Valley population of Costa Rica
    Edward A Ruiz-Narváez
    Slone Epidemiology Center, Boston University, Boston, MA, USA
    Hum Genet 127:629-38. 2010
    ..20 (1.01, 1.42). These results show that the high variability of admixture proportions in the Central Valley population offers a unique opportunity to uncover the genetic basis of ethnic differences on the risk of disease...
  82. ncbi Should obesity be blamed for the high prevalence rates of hypertension in black South African women?
    A E Schutte
    School for Physiology, Nutrition and Consumer Sciences, North West University, Potchefstroom, South Africa
    J Hum Hypertens 22:528-36. 2008
    ..The results, however, suggest a link with the development of insulin resistance...
  83. ncbi Long-term outcome of peripartum cardiomyopathy in a population with high seropositivity for human immunodeficiency virus
    Karen Sliwa
    Soweto Cardiovascular Research Unit, Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Int J Cardiol 147:202-8. 2011
    ..Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy with a high risk of mortality. The present study assessed clinical outcome and mortality over a 2-year period in an African cohort of 80 PPCM patients...
  84. ncbi Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
    Itsik Pe'er
    Department of Computer Science, Columbia University, New York, New York, USA
    Genet Epidemiol 32:381-5. 2008
    ..We further identify the sensitivity of the testing burden to the required significance level, with implications to staged design of association studies...
  85. ncbi Ethnic differences in serum lipoproteins and their determinants in South African women
    Julia H Goedecke
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, 7700 South Africa
    Metabolism 59:1341-50. 2010
    ..The major determinants of serum lipids in black women were socioeconomic status and lifestyle factors, whereas in white women, S(I) and body composition most closely correlated with serum lipids...
  86. pmc Diabetes and other disorders of glycemia in a rural South African community: prevalence and associated risk factors
    Ayesha A Motala
    Department of Endocrinology, University of KwaZulu Natal, Durban, South Africa
    Diabetes Care 31:1783-8. 2008
    ..The purpose of this study was to determine the prevalence of diabetes, impaired glucose tolerance (IGT), impaired fasting glycemia (IFG), and associated risk factors in a rural South African black community...
  87. ncbi African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia
    Candelaria Vergara
    Institute for Immunological Research, University of Cartagena, Bolivar, Colombia
    Hum Genet 125:565-79. 2009
    ..Our findings indicate that genetic factors can explain the association between asthma and African ancestry and suggest that this sample is a useful resource for performing admixture mapping for asthma...
  88. pmc Rationale and study design of a cross sectional study documenting the prevalence of Heart Failure amongst the minority ethnic communities in the UK: the E-ECHOES Study (Ethnic--Echocardiographic Heart of England Screening Study)
    Paramjit S Gill
    Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    BMC Cardiovasc Disord 9:47. 2009
    ....
  89. pmc A genomewide admixture mapping panel for Hispanic/Latino populations
    Xianyun Mao
    Department of Anthropology, The Pennsylvania State University, University Park, PA 16801, USA
    Am J Hum Genet 80:1171-8. 2007
    ..This genomewide AM panel will make it possible to apply AM approaches in many admixed populations throughout the Americas...
  90. pmc Eurasian and Sub-Saharan African mitochondrial DNA haplogroup influences pseudoexfoliation glaucoma development in Saudi patients
    Khaled K Abu-Amero
    Ophthalmic Genetics Laboratory, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Mol Vis 17:543-7. 2011
    ..To investigate whether different mitochondrial DNA (mtDNA) haplogroups have a role on the development of pseudoexfoliation glaucoma (PEG) in the Saudi Arab population...
  91. ncbi Insights into the demographic history of African Pygmies from complete mitochondrial genomes
    Chiara Batini
    Institut de Biologia Evolutiva CSIC UPF, Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 28:1099-110. 2011
    ....
  92. pmc Voluntary participation and informed consent to international genetic research
    Patricia A Marshall
    Department of Bioethics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4976, USA
    Am J Public Health 96:1989-95. 2006
    ..We compared voluntary participation and comprehension of informed consent among individuals of African ancestry enrolled in similarly designed genetic studies of hypertension in the United States and Nigeria...
  93. ncbi Frequency of dementia etiologies in four ethnic groups
    Craig E Hou
    Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
    Dement Geriatr Cogn Disord 22:42-7. 2006
    ..Research on dementia among ethnically diverse populations in the USA has focused primarily on Alzheimer disease and vascular dementia, but there are limited data on other neurodegenerative causes of dementia...
  94. pmc Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa
    Taras K Oleksyk
    Department of Biology, University of Puerto Rico at Mayaguez, Mayaguez, Puerto Rico
    PLoS ONE 5:e11474. 2010
    ..The population-specific divergence in MYH9 risk allele frequencies among the world's populations may prove important in risk assessment and public health policies to mitigate the burden of kidney disease in vulnerable populations...
  95. ncbi Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status
    John F Randolph
    Clinical Centers University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 88:1516-22. 2003
    ..All hormone concentrations were significantly correlated with body mass index. We conclude that serum sex steroid, FSH, and SHBG levels vary by ethnicity, but are highly confounded by ethnic disparities in body size...
  96. pmc The associations between socio-economic status and major depressive disorder among Blacks, Latinos, Asians and non-Hispanic Whites: findings from the Collaborative Psychiatric Epidemiology Studies
    A R Gavin
    School of Social Work, University of Washington, Seattle, WA 98105 6299, USA
    Psychol Med 40:51-61. 2010
    ....
  97. ncbi Association of weight change with ethnicity and life course socioeconomic position among Brazilian civil servants
    Dora Chor
    Department of Epidemiology, National School of Public Health, Oswaldo Cruz Foundation, R Leopoldo Bulhoes 1480, Rio de Janeiro, Brazil
    Int J Epidemiol 33:100-6. 2004
    ..We evaluated ethnic differences in adult weight change and the role of life course SEP in those differences...
  98. pmc Ethnic disparities in access to care in post-apartheid South Africa
    Zeida R Kon
    Department of Health Management and Policy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Am J Public Health 98:2272-7. 2008
    ..We investigated ethnic disparities in obtaining medical care among the 4 major ethnic groups (Blacks, Whites, Coloreds [i.e., those of mixed race], and Asians) in post-apartheid South Africa...
  99. ncbi Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, University of California, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
    Pediatrics 115:e561-5. 2005
    ..Obesity and insulin resistance are major established risk factors for NAFLD. The role of gender, race, and ethnicity on the prevalence of fatty liver in obese children is unknown...
  100. pmc Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
    Andrew E Fry
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 18:2683-92. 2009
    ..98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency...
  101. ncbi Is the current BMI obesity classification appropriate for black and white postmenopausal women?
    E M Evans
    Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Urbana 61801, USA
    Int J Obes (Lond) 30:837-43. 2006
    ..To evaluate the relation between body fatness (%Fat) and body mass index (BMI) and to evaluate the validity of the BMI standards for obesity established by the NIH in older black and white postmenopausal women...

Research Grants84

  1. Genomics Scholar Program
    Ramana Madupu; Fiscal Year: 2013
    ..During their internship at JCVI we propose to engage the Fellows in diverse research activities situated within a portfolio of research and education initiatives operated by the JCVI. ..
  2. RECOMBINANT DNA INVESTIGATION OF GALACTOSEMIA
    Randall Heidenreich; Fiscal Year: 1991
    ..Automated instruments described elsewhere in this grant will facilitate analysis of data. Several other laboratories are also engaged in molecular biology research and represent a renewing source of advisory expertise...
  3. WEB DUBOIS COLLECTIVE RESEARCH INSTITUTE
    MARGARET SPENCER; Fiscal Year: 2003
    ..g., color prejudice, under employment) that suggest the need to essentially redefine success or productivity within minority communities constrained by unique and chronic economic, social,a nd political issues. ..
  4. THE ACQUISTION OF SEX-TYPES AND OTHER STEREOTYPES
    KENNETH MC GRAW; Fiscal Year: 1980
    ..The saliency is apparent in the fact that children sex type occupations and activities as early as age two. An empirical assessment of the saliency of sex relative to age, race, and glasses will be obtained as part of Experiment 1...
  5. African-American Breast Cancer Survivor Quality of Life
    Kathleen Russell; Fiscal Year: 2003
    ..Data will be analyzed using multivariate analysis of variance procedures to address differences between groups. ..
  6. Depression in Black and White Adolescent Girls
    Debra Franko; Fiscal Year: 2002
    ....
  7. Using Social Risk to Guide Coronary Heart Disease (CHD) Preventive Treatment
    Kevin Fiscella; Fiscal Year: 2009
    ..Implementation of such a global risk tool could ultimately help justify implementation of more intensive behavioral interventions focusing on diet, exercise, smoking cessation and medication adherence for those at highest social risk. ..
  8. Randomized Control Trial of Mifepristone for Fibroids
    Kevin Fiscella; Fiscal Year: 2004
    ..The study may also offer valuable insight into a mechanism by which mifepristone reduces fibroid size. ..
  9. Do Reporting Biases Mitigate Disparity Estimates?
    Kevin Fiscella; Fiscal Year: 2004
    ..abstract_text> ..
  10. The Impact of HMO's on Disparties
    Kevin Fiscella; Fiscal Year: 2004
    ..If the study hypotheses are confirmed, the findings will underscore the need for HMOs to track and address disparities among their members if the Healthy People 2010 for the elimination of disparities is to be achieved. ..
  11. DATA COORDINATING CENTER FOR EARLY GLAUCOMA TRIAL
    M Leske; Fiscal Year: 2004
    ....
  12. Social Inequalities in Periodontal Diseases
    Luisa Borrell; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. The Barbados Study of Ocular Conditions (BSOC)
    Suh Yuh Wu; Fiscal Year: 2005
    ..The considerably high participation in the cohort (84% in BES, 85% in BISED, and 81% in BISED II), as well as the experience of the research team support the feasibility and yield of the proposed study. ..
  14. Determinants and Consequences of Alcohol Consumption
    Frank Sloan; Fiscal Year: 2008
    ..abstract_text> ..
  15. Ethnicity, Alcohol, and Spousal Violence
    Raul Caetano; Fiscal Year: 2008
    ..collecting data from both couple members. ..
  16. Brief Intervention to Reduce Injury in Minorities
    Raul Caetano; Fiscal Year: 2006
    ....
  17. PRIVATE AND SOCIAL COST OF SMOKING
    Frank Sloan; Fiscal Year: 2001
    ..We will examine implications of our empirical analysis for tort claims brought against tobacco companies and the evolution of legal theories underlying tobacco tort litigation in a law review article. ..
  18. The Antecedents and Implications of Intergroup Anxiety
    E Plant; Fiscal Year: 2002
    ..abstract_text> ..
  19. Visual Impairment, Treatment and Effects on the Elderly
    Frank Sloan; Fiscal Year: 2008
    ..Ten papers are anticipated for this four-year study. [unreadable] [unreadable]..
  20. RACIAL AND NEIGHBORHOOD DISPARITIES IN INFANT HEALTH
    Irma Elo; Fiscal Year: 2002
    ..The sample composition will permit us to address explicitly the role of race in infant health, and to examine whether factors contributing to infant health are similar for low income women in all racial/ethnic groups. ..
  21. Alcohol Epidemiology In Hispanic National Groups
    Raul Caetano; Fiscal Year: 2007
    ..Results from this study will fill a major gap in epidemiology among U.S. Hispanics, and will have implications for the development of prevention interventions. ..
  22. Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 gene
    Xingguang Luo; Fiscal Year: 2010
    ..In a word, this study will identify some risk genes for alcohol dependence, helping us better understand the etiology of alcohol dependence and provide potential targets for new drugs. ..
  23. Cross Ethnic Trends In Drinking, Alcohol Use Disorders And Service Utilization
    Raul Caetano; Fiscal Year: 2010
    ..The proposed aims will cover important gaps in significant areas of alcohol epidemiology. Trends analyses covering the period under focus and contrasting Whites, Blacks and Hispanics have not been reported yet in the alcohol literature. ..
  24. BRCA1 TESTING IN A LARGE AFRICAN AMERICAN KINDRED
    Anita Kinney; Fiscal Year: 2003
    ..abstract_text> ..
  25. Psychosocial Determinants of Nutrient Intake in Girls
    Ruth Striegel Moore; Fiscal Year: 2004
    ..Adult weight was also measured. Results from our secondary analyses will be useful for interventions aimed at improving nutritional health. ..
  26. PREVENTIVE ONCOLOGY AWARD
    Anita Kinney; Fiscal Year: 2003
    ..The University of Utah is a major academic institution with many distinguished scientists, and offers an excellent environment for Dr. Kinney to develop her skills and gain additional expertise to accomplish her goals. ..
  27. Outcome and Quality of Life after Diabetic Stroke
    Brett Kissela; Fiscal Year: 2007
    ..It is the goal of the Prinicipal Investigator to become an expert in epidemiology and outcomes research and to use clinical research to improve the lives of diabetic patients with stroke. ..
  28. The Social Context of Disclosure and HIV Sexual Risk among Bisexual Black Men
    David Malebranche; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. The significance of racial segregation for CV disease
    Mary Vaughan Sarrazin; Fiscal Year: 2007
    ..The knowledge gained from this study about the significance of segregation as a determinant of racial disparity will be essential for designing effective strategies for eliminating disparities. [unreadable] [unreadable] [unreadable]..
  30. Opioid Prescribing Patterns in the U.S.
    Mark Pletcher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. Stress, Sleep and Emerging CVD Risk Factors
    Karen Matthews; Fiscal Year: 2007
    ..The study will provide novel data testing the relationships of daytime stressful events, SDB, and other nocturnal physiological measures with the emerging risk factors and subclinical CVD measured in HeartSCORE. [unreadable] [unreadable]..
  32. Race & Breast Cancer Estrogen Receptor Status: Impact of Class and Missing Data
    Nancy Krieger; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  33. A Women's-Only Phase II Cardiac Rehabilitation Program
    THERESA BECKIE; Fiscal Year: 2007
    ..The findings have the potential to influence a paradigm shift for clinical practice and lead to important policy changes. ..
  34. Does Marriage in Sweden Affect Child and Adult Outcomes?
    DONNA GINTHER; Fiscal Year: 2007
    ..in policy? 5) Does the type of selection into marriage (self-selection compared with response to policy change) matter for outcomes? 6) Does the duration of marriage affect child and adult outcomes? [unreadable] [unreadable] [unreadable]..
  35. Understanding Reversed Race/Ethnic Associations with Cancer Screening Tests
    William Rakowski; Fiscal Year: 2008
    ..Fifth, it will be possible to look for trends over time in the presence of reversals of association for repeat screening. [unreadable] [unreadable] [unreadable]..
  36. Injury from Sexual Assault: Addressing Health Disparity
    Marilyn S Sommers; Fiscal Year: 2010
    ..Public Health Relevance: Violence against women is a silent epidemic. The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  37. Risk of Adverse Outcomes after Spinal Cord Injury: A Longitudinal Study
    James S Krause; Fiscal Year: 2010
    ..abstract_text> ..
  38. ACTIVITY AND OBESITY IN US BLACK & NIGERIAN WOMEN
    Amy Luke; Fiscal Year: 2004
    ..The proposed study will not use an ecologic design, since conclusions will be based relationships defined among individuals, not the comparison of group means. ..
  39. Breast Cancer After The Women?s Health Initiative Study: Declining Incidence?
    Nancy Krieger; Fiscal Year: 2008
    ..The knowledge gained will lead to new insights about the causes of breast cancer and ways its incidence can be reduced. [unreadable] [unreadable] [unreadable]..
  40. Defining the Clinical Significance of HbA1c Prior to the Onset of Diabetes
    Elizabeth Selvin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  41. Epidemiology of Regulatory T Cells in Pregnancy and Childhood Atopic Diseases
    Ganesa Wegienka; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  42. A Pilot Smoking Cessation Study for Newly Diagnosed Lung Cancer Patients
    Elyse Park; Fiscal Year: 2008
    ..We propose to assess the efficacy and potential feasibility of a combined behavioral and pharmacological treatment program that is integrated into the thoracic oncology setting. [unreadable] [unreadable] [unreadable]..
  43. Pittsburgh Mind-Body Center-II
    Karen Matthews; Fiscal Year: 2008
    ..Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible. ..
  44. Alcohol-Metabolizing Gene Variation, Lipids, Hemostatic Factors and CVD
    Kelly Volcik; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  45. Racial Discrimination and Risk of Chronic Disease
    Nancy Krieger; Fiscal Year: 2010
    ....
  46. Antioxidant nutrients and Oxidative DNA Damage in Afric*
    Jessie Satia; Fiscal Year: 2005
    ..In addition, this work would potentially provide investigators with a validated instrument for assessing antioxidant nutrient exposure in population-based studies in the U.S. ..
  47. Metabolic Syndrome and Cognitive Impairment
    Kristine Yaffe; Fiscal Year: 2005
    ..If elders with metabolic syndrome have increased risk of developing cognitive impairment, this would have important clinical and public health significance. ..
  48. Etiology of Geographic and Racial Differences in Stroke
    George Howard; Fiscal Year: 2001
    ....
  49. Socioeconomic Trends in Breast Cancer Incidence
    Nancy Krieger; Fiscal Year: 2005
    ..Results of this investigation will provide new insights into social determinants of and secular changes in breast cancer incidence, with implications for breast cancer surveillance, screening and control. ..
  50. Diverse Screening Histories--Persons, Groups, Behaviors
    William Rakowski; Fiscal Year: 2005
    ..Mentored junior investigators will participate in these activities, as they develop their own programs of research. ..
  51. AREA-BASED SOCIOECONOMIC MEASURES FOR HEALTH DATA
    Nancy Krieger; Fiscal Year: 2003
    ....
  52. CANCER COURSES FOR NURSES WORKING WITH MINORITY GROUPS
    Sandra Millon Underwood; Fiscal Year: 2004
    ..to be tested will focus on the degree to which the program facilitates the integration of didactic content, thoughtful discussions, clinical/laboratory experiences, related literature, evidence-based information obtained from the ..
  53. Diet, Colon Cancer, and Cancer Communications
    Jessie Satia; Fiscal Year: 2005
    ..Obtaining this award will greatly broaden and strengthen the candidate's focus on cancer prevention and control. ..
  54. Analysis of the Cardiac Access Study
    Thomas LaVeist; Fiscal Year: 2003
    ..abstract_text> ..
  55. PREVALENCE AND IMPACT OF GLAUCOMA AMONG THE VERY ELDERLY
    David Friedman; Fiscal Year: 2003
    ..Finally, the interactions between comorbidities (including cognitive deficits) and visual field loss will be explored. ..
  56. ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMEN
    Kristine Yaffe; Fiscal Year: 2002
    ..This award will foster the applicant's development towards becoming an independent investigator in aging research. ..
  57. A PROSPECTIVE STUDY OF RISK OF MORTALITY AFTER SCI
    James Krause; Fiscal Year: 2002
    ..Risk profiles will be generated to identify individuals at greatest risk for early mortality. Separate analyses and risk profiles will be generated based on injury severity, gender and race/ethnicity. ..
  58. Genetics of Lipoproteins in Afro-Caribbean Families
    Iva Miljkovic Gacic; Fiscal Year: 2007
    ..Our long-term goal is to dissect the genetic architecture of traditional and nuclear magnetic spectroscopy (NMR) measured lipoprotein phenotypes in extended, multi-generational families of African heritage. [unreadable] [unreadable]..
  59. Geocoding, Census Data & Social Disparities in Health
    Nancy Krieger; Fiscal Year: 2005
    ....
  60. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
    ..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
  61. Dietary Supplements and Lung & Colorectal Cancer Risk
    Jessie Satia; Fiscal Year: 2006
    ..abstract_text> ..
  62. Impact of Certificate of Need on the Use of Revascularization for AMI
    Mary Vaughan Sarrazin; Fiscal Year: 2006
    ..g., revascularization, mortality) and Cox regression with stratification for time-to-event outcomes (e.g., time to readmission). [unreadable] [unreadable]..
  63. Serum Protemic Patterns Associated With Atherosclerosis
    Mark Pletcher; Fiscal Year: 2006
    ....
  64. Persistence and Desistence in Heavy Drinking and Violence
    Helene R White; Fiscal Year: 2010
    ..Within a 2-year period, we will be able to make a significant contribution to the scholarly literature and provide data to be used in the development of targeted pre,vention programs. ..
  65. BIOLOGICAL BASIS OF THE PERIMENOPAUSE
    DAVID SEIFER; Fiscal Year: 2002
    ....
  66. Chronic Kidney Disease Morbidity, Mortality & Predictors
    Stephen Derose; Fiscal Year: 2005
    ..Researchers may use this information to generate hypotheses and plan studies that include subjects with CKD. ..
  67. Autonomic Function in Insulin Resistance and Diabetes
    Mercedes Carnethon; Fiscal Year: 2005
    ..abstract_text> ..
  68. MH Services & Predictors of Learning in Urban Schools
    Marc Atkins; Fiscal Year: 2009
    ..abstract_text> ..
  69. BIOPTERIN, CATECHOLAMINES, & NO IN REGULATING APOPTOSIS
    Robert Levine; Fiscal Year: 2002
    ..These studies may will reveal novel apoptotic regulatory mechanisms and provide new avenues for therapeutic approaches to promote neuronal survival and prevent debilitating neurological diseases, such as Parkinson's disease. ..
  70. Bone Health in Pediatric Crohn Disease: A Low Magnitude Mechanical Stimulus Trial
    MARY BETH LEONARD; Fiscal Year: 2010
    ..The NIH Osteoporosis Consensus Statement called for studies to identify interventions that promote bone health in children at risk. LMMS may provide a safe and effective treatment for myriad chronic pediatric diseases. ..
  71. HIV, Race and Survival in the Highly Active Therapy Era
    Thomas Giordano; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  72. Neurobiologic Study of Psychological Distress & Dementia
    Robert S Wilson; Fiscal Year: 2010
    ....
  73. Structural Bone Disease in Chronic Renal Insufficiency
    Mary Leonard; Fiscal Year: 2007
    ..Accurate characterization of bone structure in CRI is necessary to identify risk factors for fragility, and to evaluate potential therapies. ..
  74. Vascular Depression and Function in Older Latinos
    HECTOR GONZALEZ; Fiscal Year: 2007
    ..abstract_text> ..
  75. Incarceration Effects on Prevention of Drug Use, STI-HIV and Recidivism
    Seijeoung Kim; Fiscal Year: 2008
    ..Improving the health of this population-at-risk will help protect the health and well-being of the public. [unreadable] [unreadable] [unreadable]..
  76. Changes in Alcohol Availability and HIV Rates
    Richard Scribner; Fiscal Year: 2009
    ..Study Hypothesis 2: Changes in alcohol outlet density at the census tract level will explain a significant amount of the trend in HIV/AIDS and gonorrhea rates over the study period. ..
  77. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  78. Epidemiology of Subclinical Atherosclerosis in SLE
    Lisabeth Scalzi; Fiscal Year: 2008
    ..SLE, an inflammatory and immune-dysregulated disease, may provide an ideal model of CVD. ..
  79. Pathways From Subtypes of Aggression to Substance Use
    Paula Fite; Fiscal Year: 2007
    ....
  80. Hypertension Pharmacogenetics
    Julie Johnson; Fiscal Year: 2006
    ..The proposed studies should add substantial new information about antihypertensive pharmacogenetics, and could influence how antihypertensive medications are prescribed in the future. ..
  81. Progression of sub-clinical Atherosclerosis
    Joseph Polak; Fiscal Year: 2009
    ..This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers. ..
  82. College Alcohol Environmental and College Drinking
    Richard Scribner; Fiscal Year: 2007
    ..The project represents an initial effort at understanding the relative importance of campus/community level factors in impacting college drinking outcomes. Such knowledge is essential for the development of effective prevention efforts. ..