monozygotic twins

Summary

Summary: Two off-spring from the same PREGNANCY. They are from a single fertilized OVUM that split into two EMBRYOS. Such twins are usually genetically identical and of the same sex.

Top Publications

  1. ncbi Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 Canada
    Schizophr Bull 29:169-78. 2003
  2. pmc Epigenetic differences arise during the lifetime of monozygotic twins
    Mario F Fraga
    Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 102:10604-9. 2005
  3. pmc Viruses in the faecal microbiota of monozygotic twins and their mothers
    Alejandro Reyes
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 466:334-8. 2010
  4. ncbi Infant zygosity can be assigned by parental report questionnaire data
    T S Price
    Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    Twin Res 3:129-33. 2000
  5. ncbi Regional gray matter volume in monozygotic twins concordant and discordant for schizophrenia
    Stefan J Borgwardt
    Section of Neuroimaging, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 67:956-64. 2010
  6. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
  7. ncbi Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
    G Kuratomi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa, Wako, Saitama, Japan
    Mol Psychiatry 13:429-41. 2008
  8. pmc Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    PLoS Med 5:e51. 2008
  9. ncbi Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
    N Matigian
    Queensland Centre for Mental Health Research, Herston, QLD, Australia
    Mol Psychiatry 12:815-25. 2007
  10. pmc Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis
    Sergio E Baranzini
    Department of Neurology, University of California at San Francisco, San Francisco, California 94143, USA
    Nature 464:1351-6. 2010

Research Grants

Detail Information

Publications311 found, 100 shown here

  1. ncbi Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 Canada
    Schizophr Bull 29:169-78. 2003
    ..were investigated in the 5'-regulatory region of the dopamine D2 receptor gene (DRD2) in two pairs of monozygotic twins, one concordant and one discordant for schizophrenia...
  2. pmc Epigenetic differences arise during the lifetime of monozygotic twins
    Mario F Fraga
    Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 102:10604-9. 2005
    ..the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older ..
  3. pmc Viruses in the faecal microbiota of monozygotic twins and their mothers
    Alejandro Reyes
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 466:334-8. 2010
    ..metagenomes) of virus-like particles isolated from faecal samples collected from healthy adult female monozygotic twins and their mothers at three time points over a one-year period...
  4. ncbi Infant zygosity can be assigned by parental report questionnaire data
    T S Price
    Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    Twin Res 3:129-33. 2000
    ..The results validate the use of parental report questionnaire data to determine zygosity in infancy...
  5. ncbi Regional gray matter volume in monozygotic twins concordant and discordant for schizophrenia
    Stefan J Borgwardt
    Section of Neuroimaging, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 67:956-64. 2010
    ..We investigated the influence of genetic and environmental risk on GMV in monozygotic (MZ) twin pairs concordant and discordant for schizophrenia...
  6. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
    ..In line with several recent studies, the present findings further support the view that the cortisol awakening responses is consistently enhanced under chronic stress conditions...
  7. ncbi Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
    G Kuratomi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa, Wako, Saitama, Japan
    Mol Psychiatry 13:429-41. 2008
    To search DNA methylation difference between monozygotic twins discordant for bipolar disorder, we applied a comprehensive genome scan method, methylation-sensitive representational difference analysis (MS-RDA) to lymphoblastoid cells ..
  8. pmc Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
    PLoS Med 5:e51. 2008
    ..The goal of this study was to investigate this important acquired component and expose obesity-induced changes in biological pathways in an identical genetic background...
  9. ncbi Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
    N Matigian
    Queensland Centre for Mental Health Research, Herston, QLD, Australia
    Mol Psychiatry 12:815-25. 2007
    ..The differentially regulated genes and pathways identified in this study may provide insights into the biology of BD1...
  10. pmc Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis
    Sergio E Baranzini
    Department of Neurology, University of California at San Francisco, San Francisco, California 94143, USA
    Nature 464:1351-6. 2010
    ..disease and common cause of neurodegeneration and disability in young adults, disease discordance in monozygotic twins has been interpreted to indicate environmental importance in its pathogenesis...
  11. ncbi Twinning
    Judith G Hall
    Department of Paediatrics, 4480 Oak Street, Room 2D19, British Columbia s Children s Hospital, BC, V6H 3V4, Vancouver, Canada
    Lancet 362:735-43. 2003
    ..Artificial reproductive technologies have led to a pronounced rise in numbers of dizygotic and monozygotic twins. Although spontaneous dizygotic twinning is clearly associated with increased concentration of follicle-..
  12. ncbi Monozygotic twins discordant for major depression: a preliminary exploration of the role of environmental experiences in the aetiology and course of illness
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 31:411-23. 2001
    ..Genetic effects upon behaviour are pervasive. To what extent are the many correlates of major depression (MD) due to individual-specific environmental experiences versus genetic factors correlated with risk for MD?..
  13. ncbi Investigations into the influence of host genetics on the predominant eubacteria in the faecal microflora of children
    Jessica A Stewart
    Wakefield Gastroenterology Research Institute, Wakefield Hospital, Private Bag 7909, Wellington South, New Zealand
    J Med Microbiol 54:1239-42. 2005
    ..001). The results of this study indicate that host genetics influence the composition of the dominant eubacterial population in children...
  14. ncbi Familial aggregation of leisure-time physical activity -- a three generation study
    M Aarnio
    Department of Public Health, University of Helsinki, Finland
    Int J Sports Med 18:549-56. 1997
    ..Because physical activity patterns do not appear to be transmitted from one generation to the next, it is probable that by constant training and education we can obtain the benefits of physical activity...
  15. ncbi Monozygotic twins and transfer at the blastocyst stage after ICSI
    A L da Costa AL
    Clínica e Centro de Pesquisa em Reproducião Humana Roger Abdelmassih, Sao Paulo, Brasil
    Hum Reprod 16:333-6. 2001
    ....
  16. pmc Crossed cerebral lateralization for verbal and visuo-spatial function in a pair of handedness discordant monozygotic twins: MRI and fMRI brain imaging
    Silke Lux
    Institute of Neuroscience and Biophysics, Department of Medicine, Research Centre Julich, Germany
    J Anat 212:235-48. 2008
    ....
  17. ncbi Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome
    Rosanna Weksberg
    Division of Clinical and Metabolic Genetics and the Research Institute, Department of Paediatrics Hospital for Sick Children, Toronto, Ontario, Canada
    Hum Mol Genet 11:1317-25. 2002
    ..We show here that the incidence of female monozygotic twins among patients with BWS is dramatically increased over that of the general population...
  18. pmc Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    Diego Mastroeni
    LJ Roberts Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AZ, USA
    PLoS ONE 4:e6617. 2009
    ..In a rare set of monozygotic twins discordant for Alzheimer's disease (AD), significantly reduced levels of DNA methylation were observed in ..
  19. pmc Monozygotic twins reveal germline contribution to allelic expression differences
    Vivian G Cheung
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 82:1357-60. 2008
    ..We have measured allelic expression differences at heterozygous loci in monozygotic twins and in unrelated individuals...
  20. ncbi Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences
    Jerry R Greenfield
    Department of Endocrinology, St Vincent s Hospital, Sydney, Australia
    Circulation 109:3022-8. 2004
    ..The aim of this study was to examine the relationship between CRP and accurately measured body fat, lipids, apolipoproteins, blood pressure, and environmental and behavioral factors, independent of genetic influences...
  21. ncbi Physiologic responses to sudden, loud tones in monozygotic twins discordant for combat exposure: association with posttraumatic stress disorder
    Scott P Orr
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Gen Psychiatry 60:283-8. 2003
    ..Studying identical twins discordant for traumatic exposure offers an opportunity to resolve these competing origins...
  22. pmc Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes
    Valerie W Hu
    The George Washington University Medical Center, Dept of Biochemistry and Molecular Biology, 2300 Eye St, N W Washington, DC 20037, USA
    BMC Genomics 7:118. 2006
    ....
  23. ncbi Clozapine-induced weight gain: a study in monozygotic twins and same-sex sib pairs
    Frank M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, D 35039 Marburg, Germany
    Psychiatr Genet 15:285-9. 2005
    ..and upon additional inclusion of BMI change under prior antipsychotic medication (total DeltaBMI) of five monozygotic twins in comparison with seven same-sex sibs...
  24. ncbi Genetic factors in physical activity and the equal environment assumption-- the Swedish young male twins study
    Marit Eriksson
    The Child and Adolescent Public Health Epidemiology Group, Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden
    Behav Genet 36:238-47. 2006
    ..The EEA was investigated with a linear regression model, examining if the twins contact frequency predicted within-pair differences in PA, and further by a simulation study. We found no support for violation of the EEA...
  25. ncbi Favourable effect of TNF-alpha inhibitor (infliximab) on Blau syndrome in monozygotic twins with a de novo CARD15 mutation
    Nils Milman
    Department of Medicine B, Division of Lung Transplantation, Rigshospitalet, University of Copenhagen, Copenhage, Demark
    APMIS 114:912-9. 2006
    ..In children, discrimination between early onset sarcoidosis and Blau syndrome should include a CARD15 mutation analysis...
  26. ncbi Cerebral asymmetries in monozygotic twins: an fMRI study
    Gjurgjica Badzakova-Trajkov
    Department of Psychology, Research Centre for Cognitive Neuroscience, The University of Auckland, Auckland, New Zealand
    Neuropsychologia 48:3086-93. 2010
    ..Our data suggest that the same gene has no influence on right-hemisphere dominance for spatial judgment or face processing, and offer little support for mirror-imaging in MZ twins other than that due to chance...
  27. ncbi Monozygotic twins with idiopathic internal root resorption: A case report
    Daniel Urban
    1st Department of Stomatology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia
    Aust Endod J 36:79-82. 2010
    This study presents the first case of internal root resorption in monozygotic twins. Genetic factors have been implicated in the development of root resorption lesions...
  28. pmc Cavum septum pellucidum in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder
    Flavia S May
    Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 55:656-8. 2004
    ..Abnormally large cavum septum pellucidum has been reported in posttraumatic stress disorder; however, the origin of this association is uncertain...
  29. ncbi Genetic versus environmental aetiology of the metabolic syndrome among male and female twins
    P Poulsen
    Odense University Hospital, Department of Endocrinology, Denmark
    Diabetologia 44:537-43. 2001
    ..The heritability estimates for glucose concentration, BMI and HDL-cholesterol among monozygotic twins confirmed these findings...
  30. ncbi Somatic mosaicism for chromosome X and Y aneuploidies in monozygotic twins heterozygous for sickle cell disease mutation
    Hamid Reza Razzaghian
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Am J Med Genet A 152:2595-8. 2010
    ....
  31. pmc Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies
    A A Karatza
    Department of Maternal Fetal Medicine, Queen Charlotte s and Chelsea Hospital, Imperial College, London, UK
    Heart 88:271-7. 2002
    ..To test the hypothesis that identical twins show no inter-twin differences in cardiovascular structure or physiology in fetal life unless there has been twin-twin transfusion syndrome...
  32. ncbi Neuroanatomic alterations and social and communication deficits in monozygotic twins discordant for autism disorder
    Shanti R Mitchell
    Department of Psychiatry, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA
    Am J Psychiatry 166:917-25. 2009
    Investigating neuroanatomic differences in monozygotic twins who are discordant for autism can help unravel the relative contributions of genetics and environment to this pervasive developmental disorder...
  33. ncbi Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:557-64. 2008
    ..However, the pathophysiology of schizophrenia has not been totally elucidated yet. To date, studies of monozygotic twins discordant for schizophrenia have provided insight into the pathophysiology of this illness; this type of ..
  34. ncbi Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins
    Tania Perrinjaquet-Moccetti
    Frutarom Switzerland Ltd, CH 8820 Wadenswil, Switzerland
    Phytother Res 22:1239-42. 2008
    ..actions in rats, was tested as a food supplement in an open study including 40 borderline hypertensive monozygotic twins. Twins of each pair were assigned to different groups receiving 500 or 1000 mg/day EFLA943 for 8 weeks, or ..
  35. pmc Association between birth weight and adult blood pressure in twins: historical cohort study
    N R Poulter
    Cardiovascular Studies Unit, Department of Clinical Pharmacology, Imperial College School of Medicine, St Mary s Campus, London W2 1PG
    BMJ 319:1330-3. 1999
    ..To evaluate the associations in twins between within pair differences in birth weight and subsequent blood pressures as adults thereby removing the impact of potential parental confounding variables...
  36. ncbi Hand preference and performance in 20 pairs of monozygotic twins with discordant handedness
    Jennifer M Gurd
    University Department of Clinical Neurology, University of Oxford, Oxford, UK
    Cortex 42:934-45. 2006
    ..Forty female monozygotic twins (20 pairs) were selected on the basis of discordance of writing hand...
  37. ncbi Fumarate hydratase deficiency in monozygotic twins
    Tonya M Phillips
    Department of Pediatrics, Division of Neurology, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, Arkansas, USA
    Pediatr Neurol 35:150-3. 2006
    b>Monozygotic twins with fumarate hydratase deficiency presenting with profound hypotonia and developmental delay are reported...
  38. pmc Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy
    Robert J Ferguson
    Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA
    J Clin Oncol 25:3866-70. 2007
    ..Late cognitive effects after chemotherapy can have a deleterious impact on survivor quality of life and functional health; however, the etiology of chemotherapy-related cognitive dysfunction remains unknown...
  39. ncbi Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins
    Araceli Rosa
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:459-62. 2008
    ....
  40. pmc Gene expression in peripheral blood leukocytes in monozygotic twins discordant for chronic fatigue: no evidence of a biomarker
    Andrea Byrnes
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5805. 2009
    ..Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes...
  41. ncbi Natural variation in human gene expression assessed in lymphoblastoid cells
    Vivian G Cheung
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 33:422-5. 2003
    ..phenotype by comparing variation among unrelated individuals, among siblings within families and between monozygotic twins. These observations suggest that there is a genetic contribution to polymorphic variation in the level of ..
  42. pmc Clones in the classroom: a daily diary study of the nonshared environmental relationship between monozygotic twin differences in school experience and achievement
    Kathryn Asbury
    Social, Genetic and Developmental Psychiatry Centre, King s College London, United Kingdom
    Twin Res Hum Genet 11:586-95. 2008
    ..10, p < .05). These results indicate that MZ twins experience the classroom differently and that differences in their experience are associated with differences in their achievement...
  43. ncbi Graves' disease and Hashimoto's thyroiditis in monozygotic twins: case study as well as transcriptomic and immunohistological analysis of thyroid tissues
    G Aust
    Research Laboratories, Center of Surgery, University of Leipzig, Germany
    Eur J Endocrinol 154:13-20. 2006
    To report on the rare simultaneous occurrence of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in monozygotic twins.
  44. ncbi Neurocognitive function in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder
    Mark W Gilbertson
    Research Service, Manchester VA Medical Center, NH 03104, USA
    J Abnorm Psychol 115:484-95. 2006
    ..The results support the notion that specific domains of cognitive function may serve as premorbid risk or protective factors in PTSD...
  45. ncbi Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins
    Christian S Haas
    University of Michigan Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 54:2047-60. 2006
    ..To identify disease-specific gene expression profiles in patients with rheumatoid arthritis (RA), using complementary DNA (cDNA) microarray analyses on lymphoblastoid B cell lines (LCLs) derived from RA-discordant monozygotic (MZ) twins...
  46. ncbi The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study
    T D Cannon
    Department of Psychology, University of Pennsylvania, Philadelphia, USA
    Arch Gen Psychiatry 55:67-74. 1998
    ..We applied structural equation modeling in a total population of twins to determine the significance and magnitudes of the genetic and environmental contributions to schizophrenia...
  47. ncbi Progression and determinants of quantitative magnetic resonance imaging measures of lumbar disc degeneration: a five-year follow-up of adult male monozygotic twins
    Tapio Videman
    Faculty of Rehabilitation Medicine, University of Alberta, Alberta, Canada
    Spine (Phila Pa 1976) 33:1484-90. 2008
    ..A longitudinal study...
  48. ncbi Netherlands Twin Register: from twins to twin families
    Dorret I Boomsma
    Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Twin Res Hum Genet 9:849-57. 2006
    ..In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies...
  49. ncbi Rethinking twins and environments: possible social sources for assumed genetic influences in twin research
    Allan V Horwitz
    Institute for Health, Health Care Policy, and Aging Research, 30 College Ave, Rutgers University, New Brunswick, N J 08901 1293, USA
    J Health Soc Behav 44:111-29. 2003
    ..Bivariate comparisons indicate that monozygotic twins show greater similarity than dizygotic twins in socially-based characteristics including physical ..
  50. ncbi Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders
    T Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Mol Psychiatry 10:622-30. 2005
    ..However, if the genetic or epigenetic difference responsible for the discordant phenotype is found, it will have impact on the biology of mental disorder, in which few conclusive molecular genetic evidences have been obtained...
  51. ncbi Mechanisms for differences in monozygous twins
    P Gringras
    The Multiple Births Foundation, Hammersmith House, Level 4, Queen Charlotte s and Chelsea Hospital, Du Cane Road, London W12 OHS, UK
    Early Hum Dev 64:105-17. 2001
    ..The potential for differences in monozygotic twin pairs is an important consideration for both clinicians and researchers involved in twin work...
  52. ncbi A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation
    S J Silber
    Infertility Center of St Louis, 224 South Woods Mill Road St Louis, 63017 MO, USA
    Hum Reprod 23:1531-7. 2008
    ..A series of monozygotic (MZ) twin pairs discordant for premature ovarian failure presented an unusual opportunity to study ovarian transplantation...
  53. ncbi Not really identical: epigenetic differences in monozygotic twins and implications for twin studies in psychiatry
    F Nipa Haque
    University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet C Semin Med Genet 151:136-41. 2009
    ..In this article, we review some twin studies, and discuss the dynamic interactions between stochastic, environmental, and epigenetic variables that influence neurobiological phenotypes...
  54. pmc Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity
    Linda Mustelin
    Department of Laboratory Medicine, Division of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am J Physiol Endocrinol Metab 295:E148-54. 2008
    ..8 +/- 0.5 vs. 3.3 +/- 0.6, P < 0.01). This implies that acquired poor physical fitness is associated with defective expression of the oxidative pathway components in adipose tissue mitochondria...
  55. ncbi Heritability of neck pain: a population-based study of 33,794 Danish twins
    R Fejer
    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Rheumatology (Oxford) 45:589-94. 2006
    ..To determine the heritability of neck pain in a large population-based study of twins...
  56. ncbi Epigenetic contributors to the discordance of monozygotic twins
    S M Singh
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, Ontario, Canada
    Clin Genet 62:97-103. 2002
    ..We will review published cases of phenotypic and genetic discordance between monozygotic twins to argue that not all discordance between such twins is due to differences in environment...
  57. pmc Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles
    Carl E G Bruder
    Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 0024, USA
    Am J Hum Genet 82:763-71. 2008
    ..We studied 19 pairs of monozygotic twins with either concordant or discordant phenotype by using two platforms for genome-wide CNV analyses and ..
  58. ncbi Female monozygotic twins discordant for hemophilia A due to nonrandom X-chromosome inactivation
    Carolyn M Bennett
    Division of Hematology Oncology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Hematol 83:778-80. 2008
    ..Twin A showed nonrandom inactivation skewed toward the paternal X, whereas twin B showed random X-inactivation. This is the first reported case of discordance for hemophilia A between female monozygotic twins.
  59. ncbi [Summer-type hypersensitivity pneumonitis in monozygotic twins]
    Satoshi Mimura
    Third Department of Internal Medicine, National Defence Medical College, Saitama, Japan
    Nihon Kokyuki Gakkai Zasshi 41:133-7. 2003
    We encountered a pair of monozygotic twins with summer-type hypersensitivity pneumonitis. Patients 1 and 2 were 24-year-old men who worked in the same place and shared the same room, which was built of wood...
  60. ncbi Influence of some hereditary factors on weight loss following conservative and surgical treatment of obese female monozygotic twins
    M Fried
    1st Surgical Department, Charles University Teaching Hospital, Prague, Czech Republic
    Obes Surg 9:265-8. 1999
    ..The possible influence of some genetic factors on weight reduction or maintenance following conservative and/or surgical treatment was studied in 14 pairs of obese female monozygotic twins.
  61. ncbi Determinants of psychomotor speed among 61 pairs of adult male monozygotic twins
    R L Simonen
    Department of Health Sciences, University of Jyvaskyla, Finland
    J Gerontol A Biol Sci Med Sci 53:M228-34. 1998
    ..The present study examined the relative effects of familial aggregation (reflecting a combination of genetics and early environmental influences), and occupational, lifestyle, and health factors on psychomotor speed...
  62. ncbi Pulp stones throughout the dentition of monozygotic twins: a case report
    J M VanDenBerghe
    College of Dentistry, University of Nebraska Medical Center, Lincoln, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87:749-51. 1999
    ..This case report describes twin sisters with pulpal calcifications in their entire dentitions. No systemic cause was detected. The pattern of calcification was partially consistent with the hereditary condition of dentinal dysplasia...
  63. ncbi Monozygotic twins discordant for body stalk anomaly
    G J Daskalakis
    Harris Birthright Research Center for Fetal Medicine, Kings College Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 20:79-81. 2002
    We report on two cases of monozygotic twins discordant for body stalk anomaly, diagnosed prenatally in a multicenter ultrasound screening study at 10-14 weeks of gestation...
  64. ncbi Thalamic and caudate volumes in monozygotic twins discordantfor schizophrenia
    Nicola Bridle
    Cognitive Neuropsychiatry Research and Academic Unit, The University of Melbourne, Parkville, Victoria, Australia
    Aust N Z J Psychiatry 36:347-54. 2002
    ..Previous studies have been inconsistent in identifying structural and functional abnormalities in these structures. However, methodologies in these studies have been unreliable and some have not adequately matched patients and controls...
  65. ncbi Is education causally related to better health? A twin fixed-effect study in the USA
    Takeo Fujiwara
    Section of Behavioral Science, Department of Health Promotion, National Institute of Public Health, Wako Shi, Saitama, Japan
    Int J Epidemiol 38:1310-22. 2009
    ..The purpose of this study is to identify the causal effects of education on health and health behaviours using a twin fixed-effect approach...
  66. ncbi Daytime cortisol secretion in 6-month-old twins: genetic and environmental contributions as a function of early familial adversity
    Isabelle Ouellet-Morin
    School of Psychology, Universite Laval, Quebec City, Canada
    Biol Psychiatry 65:409-16. 2009
    ..The goals of the study were to estimate the genetic and environmental contributions to daytime cortisol secretion in infant twins and to investigate whether these contributions varied as a function of familial adversity (FA)...
  67. ncbi Antisaccade performance in monozygotic twins discordant for schizophrenia: the Maudsley twin study
    Ulrich Ettinger
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Am J Psychiatry 163:543-5. 2006
    ..Deficiency in antisaccade performance has been proposed as a schizophrenia endophenotype...
  68. ncbi Monozygotic twinning in rhesus monkeys by manipulation of in vitro-derived embryos
    Shoukhrat M Mitalipov
    Oregon Regional Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Biol Reprod 66:1449-55. 2002
    ..Neither pregnancy resulted in term birth of monozygotic twins, but our results are sufficiently encouraging to justify a large-scale twinning trial in the rhesus macaque.
  69. ncbi Corpus callosum abnormalities in Tourette syndrome: an MRI-DTI study of monozygotic twins
    Andrea E Cavanna
    Department of Neurology, Amedeo Avogadro University, Novara, Italy
    J Neurol Neurosurg Psychiatry 81:533-5. 2010
    ....
  70. ncbi Discordant clinical manifestations in monozygotic twins with the identical mutation in the TSC2 gene
    N Martin
    Clin Genet 63:427-30. 2003
  71. ncbi Discordance in Mayer-von Rokitansky-Küster-Hauser Syndrome noted in monozygotic twins
    Ugonna A Duru
    Division of Gynecology, Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr Adolesc Gynecol 22:e73-5. 2009
    ..We report a case of monochorionic, monoamniotic female twins with discordant congenital reproductive tract anomalies...
  72. ncbi A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 56:454-61. 2004
    We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities.
  73. ncbi Language lateralization in monozygotic twins discordant and concordant for schizophrenia. A functional MRI pilot study
    Filip Spaniel
    Psychiatric Center, Ustavní 191, 181 03 Prague 8, Czech Republic
    Eur Psychiatry 22:319-22. 2007
    ..Previous studies have suggested altered structural and functional asymmetry of the brain in schizophrenia...
  74. ncbi High concordance of bipolar I disorder in a nationwide sample of twins
    Tuula Kieseppä
    Department of Mental Health and Alcohol Research, National Public Health Institute, 00300 Helsinki 30, Finland
    Am J Psychiatry 161:1814-21. 2004
    ..The authors report what appears to be the first twin study of bipolar I disorder involving a population-based twin sample, in which the diagnoses were made by using structured, personal interviews...
  75. ncbi Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome
    Leslie Sherlin
    Nova Tech EEG, Inc, 8503 E Keats Ave, Mesa, AZ 85208, USA
    Neuroimage 34:1438-42. 2007
    ..Our objective was to investigate if specific frequency band-pass regions and spatial locations are associated with CFS using low-resolution electromagnetic brain tomography (LORETA)...
  76. pmc Discordance of MLL-rearranged (MLL-R) infant acute lymphoblastic leukemia in monozygotic twins with spontaneous clearance of preleukemic clone in unaffected twin
    Meredith K Chuk
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA
    Blood 113:6691-4. 2009
    Concordance of MLL-rearranged acute leukemia in infant monozygotic twins is thought to be 100% with a very short latency period, suggesting that either the MLL fusion itself is sufficient to cause leukemia or that it promotes the rapid ..
  77. ncbi Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder
    F Xavier Castellanos
    Child Psychiatry Branch, National Institute of Mental Health NIH, Bethesda, MD, USA
    Am J Psychiatry 160:1693-6. 2003
    To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD.
  78. ncbi Causal direction between respiratory syncytial virus bronchiolitis and asthma studied in monozygotic twins
    Porntiva Poorisrisak
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, L213 Ledreborg alle 34, DK 2820 Copenhagen, Denmark
    Chest 138:338-44. 2010
    ..Our aim was to determine the differential effect within monozygotic (MZ) twin pairs discordant for severe RSV bronchiolitis in infancy on the subsequent development of asthma, pulmonary function, and allergy...
  79. ncbi Two sets of monozygotic twins after intracytoplasmic sperm injection and transfer of two embryos on day 2
    Raquel Carrillo-Vadillo
    Unidad Clínica de Genética y Reproducción, Hospitales Universitarios Virgen del Rocio, Seville, Spain
    Fertil Steril 88:1676.e3-5. 2007
    To report a case of quadruple gestation (two sets of monozygotic twins) after intracytoplasmic sperm injection (ICSI) and transfer of two embryos.
  80. ncbi Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins
    Talat Islam
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Neurology 69:381-8. 2007
    ....
  81. ncbi Idiopathic scoliosis: how much of a genetic disorder? Report of five pairs of monozygotic twins
    Hans Rudolf Weiss
    Asklepios Katharina Schroth Spinal Deformities Rehabilitation Centre, Bad Sobernheim, Germany
    Dev Neurorehabil 10:67-73. 2007
    ..However, it seems questionable whether there is evidence for a genetic aetiology for adolescent idiopathic scoliosis, when in monozygotic twins there is no 100% concordance of the symptoms and prognosis.
  82. ncbi Identical unerupted maxillary incisors in monozygotic twins
    Hasan Babacan
    Department of Orthodontics, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey
    Am J Orthod Dentofacial Orthop 138:498-509. 2010
    ..The occurrence of identical unerupted maxillary central incisors and mesiodentes in monozygotic twins suggests that genetic factors might influence the etiology of this problem...
  83. ncbi Heritability of plasma leptin levels: a twin study
    K Narkiewicz
    Institute of Internal Medicine, Medical University of Gdansk, Poland
    J Hypertens 17:27-31. 1999
    ..To examine the influence of genetic factors on plasma leptin levels...
  84. ncbi Palatally displaced canine anomaly in monozygotic twins
    Rosalia Leonardi
    University of Catania, Catania, Italy
    Angle Orthod 73:466-70. 2003
    ..The finding of PDC anomaly in MZ twins--to our knowledge, the first such published case--lends further support to evidence of genetic control of the PDC anomaly...
  85. ncbi Determinants of isokinetic and psychophysical lifting strength and static back muscle endurance: a study of male monozygotic twins
    L E Gibbons
    Department of Orthopaedics, University of Washington, Seattle, USA
    Spine (Phila Pa 1976) 22:2983-90. 1997
    ..This knowledge can be used to guide more appropriate selection and interpretation of results of back muscle function tests...
  86. ncbi Characteristics of monozygotic twins discordant for bulimia nervosa
    C M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia
    Int J Eat Disord 29:1-10. 2001
    ....
  87. ncbi Discordant organ laterality in monozygotic twins with primary ciliary dyskinesia
    P G Noone
    Department of Medicine, University of North Carolina at Chapel Hill, 27599 7249, USA
    Am J Med Genet 82:155-60. 1999
    ..This is consistent with the hypothesis that situs inversus occurring in patients with primary ciliary dyskinesia is a random but "complete" event in the fetal development of patients with PCD...
  88. ncbi Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
    Caroline M Bateman
    Section of Haemato oncology, The Institute of Cancer Research, Surrey, UK
    Blood 115:3553-8. 2010
    ..This conundrum can be resolved with twin pairs. We identified and compared CNAs in 5 pairs of monozygotic twins with concordant ETV6-RUNX1-positive ALL and 1 pair discordant for ETV6-RUNX1 positive ALL...
  89. ncbi Incidence of monozygotic twins in blastocyst and cleavage stage assisted reproductive technology cycles
    Fady I Sharara
    Virginia Center for Reproductive Medicine, 11150 Sunset Hills Road, Suite 100, Reston, VA 20190, USA
    Fertil Steril 93:642-5. 2010
    To study the incidence of monozygotic twins (MZT) in blastocyst and cleavage stage ET.
  90. ncbi Risk for multiple sclerosis in dizygotic and monozygotic twins
    Thomas Hansen
    National Institute of Public Health, Oster Farimagsgade 5, DK 1399 Kobenhavn K, Denmark
    Mult Scler 11:500-3. 2005
    ..Our analyses suggest that dizygotic twins have an approximately 60% lower risk for MS than monozygotic twins and a 20% lower risk than singletons...
  91. ncbi Does higher concordance in monozygotic twins than in dizygotic twins suggest a genetic component?
    S W Guo
    Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics and Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisc, USA
    Hum Hered 51:121-32. 2001
    ..This may serve as a sobering antidote to the uncritical reliance on twin studies without examining the validity of the underlying assumptions...
  92. ncbi Joubert syndrome: monozygotic twins with discordant phenotypes
    H R Raynes
    Department of Neurology, Jacobi and Montefiore Medical Centers, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10467, USA
    J Child Neurol 14:649-54; discussion 669-72 discussio. 1999
    We describe three sisters with Joubert syndrome, two of whom are monozygotic twins with highly discordant phenotypes. The twins were born at 34 weeks' gestation with discordant birthweights...
  93. ncbi Effect of accumulated night work during the working lifetime, on subjective health and sleep in monozygotic twins
    Michael Ingre
    National Institute for Psychosocial Medicine IPM, Stockholm, Sweden
    J Sleep Res 13:45-8. 2004
    ..study sought to investigate the effects of lifetime accumulated night work on subjective health and sleep in monozygotic twins discordant on the exposure to night work...
  94. ncbi Monozygotic twins discordant for trisomy 21 and maternal 21q inheritance: a complex series of events
    Sophie Dahoun
    Genetic Medicine, University Hospitals of Geneva, Geneva, Switzerland
    Am J Med Genet A 146:2086-93. 2008
    ....
  95. ncbi High concordance for essential tremor in monozygotic twins of old age
    D Lorenz
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Neurology 62:208-11. 2004
    ..To assess the relative contribution of genetic and environmental factors for the etiology of essential tremor (ET) and to explore the effect of different diagnostic criteria...
  96. ncbi Monozygotic twins, folie à deux and heritability: a case report and critical review
    R S Shiwach
    Department of Psychiatry, UT Southwestern Medical School, Dallas, TX 75235 9070, USA
    Med Hypotheses 50:369-74. 1998
    ..In the light of this paradox, nosological status of this disorder and the sociogenic and genetic factors are critically discussed...
  97. ncbi Mosaicism of the CAG repeat sequence in the Huntington disease gene in a pair of monozygotic twins
    Anne Nørremølle
    Institute of Medical Biochemistry and Genetics, Section of Neurogenetics, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Am J Med Genet A 130:154-9. 2004
    We report on a pair of monozygotic twins belonging to a family segregating Huntington disease (HD). In routine DNA analysis of blood cells, they displayed three alleles of the CAG repeat sequence in the HD gene...
  98. ncbi Monozygotic twins with chromosome 22q11 microdeletion and discordant phenotypes in cardiovascular patterning
    J H Lu
    Department of Pediatrics, Veterans General Hospital-Taipei, National Yang-Ming University, Taipei, Taiwan, Republic of China
    Pediatr Cardiol 22:260-3. 2001
    b>Monozygotic twins with chromosome 22q11 microdeletions offer an ideal situation to observe the association of microdeletion and disrupted cardiovascular patterning. We report monozygotic twins concordant for 22q11...
  99. ncbi Different phenotypic expression in monozygotic twins with Huntington disease
    M H Anca
    Movement Disorder Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    Am J Med Genet A 124:89-91. 2004
    ..Postzygotic events are a likely explanation for the observed differences of phenotype in these genetically identical twins...
  100. ncbi Non-identical monozygotic twins, intermediate twin types, zygosity testing, and the non-random nature of monozygotic twinning: a review
    Geoffrey Machin
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Med Genet C Semin Med Genet 151:110-27. 2009
    b>Monozygotic twins (MZ) are rarely absolutely "identical." This review discusses the types of genetic/epigenetic and prenatal environmental post-zygotic mechanisms that cause discordance within such twin pairs...
  101. ncbi Synaesthesia: discordant male monozygotic twins
    Daniel Smilek
    Department of Psychology, University of Waterloo, Waterloo, Ontario, Canada
    Neurocase 11:363-70. 2005
    ..The findings also negate a previous suggestion, based on a study of female monozygotic twins, that discordance of synaesthesia in identical twins is due to X-inactivation...

Research Grants64

  1. TWINS AND RISK OF PD: A CLINICAL AND IMAGING STUDY
    Caroline Tanner; Fiscal Year: 2004
    ..strongly implicate environmental factors in the pathogenesis of Parkinson's disease, since one would expect monozygotic twins to show a much higher concordance rate than dizygotic twins if Parkinson's Disease were genetically ..
  2. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..The potential for relative oxygen insult during pregnancy, and the need to explain CHB- discordance in monozygotic twins, directed attention to hypoxia as an amplification factor on the distal fibrosing component...
  3. The human gut microbiome, malnutrition and vaccine responses
    ANDREW LEON KAU; Fiscal Year: 2013
    ..mice, colonized at 6 weeks of age with de-identified fecal microbiota already collected from several sets of monozygotic twins discordant for kwashiorkor (1 healthy/ 1 malnourished) as well as their mothers'microbiota...
  4. Roles for Global Chromatin Structure in C. elegans Longevity
    Siu Sylvia Lee; Fiscal Year: 2010
    ..histone modifications, have been observed in a variety of aging mammalian tissues and in aging human monozygotic twins. In yeast, worms, and flies, several histone modifying enzymes have been shown to play critical roles in ..
  5. Aptamer probes for Epigenetic Peptide Targets
    MARK PATRICK MCPIKE; Fiscal Year: 2010
    ..Gene expression differences in aging monozygotic twins suggest that epigenetic drift may be associated with chronic diseases that appear as we age...
  6. Monoallelic expression in neurons derived from induced pluripotent stem cells
    Herbert M Lachman; Fiscal Year: 2013
    ..help explain some interesting epidemiological features of neuropsychiatric disorders, such as discordance in monozygotic twins and reduced penetrance...
  7. Effects of Tobacco Exposure on Immune Responses
    Kari C Nadeau; Fiscal Year: 2013
    ..b>Monozygotic twins (MZT) will be studied (ages 16 to 55 yrs) who are discordant for smoking (i.e...
  8. Genome-Wide Targeted Gene Resequencing in Glaucoma
    THERESA GAASTERLAND; Fiscal Year: 2010
    ..7-10 times greater than that of the general population, and a high concordance has been observed between monozygotic twins. A number of studies have performed genome-wide scans for glaucoma susceptibility loci and have yielded ..
  9. The Role of Somatic Copy Number Changes in Aging
    REBECCA I TORENE; Fiscal Year: 2013
    ..Using array comparative genomic hybridization (aCGH), the copy number changes that occur in monozygotic twins and mice as they age will be determined...
  10. MRI DNA Biomarkers for Neuropsychiatric Disease
    GUALBERTO RUANO; Fiscal Year: 2011
    ..It is highly heritable, with concordance rates of 50-80% in monozygotic twins and substantial familial clustering...
  11. Mice Harboring Human DISC1-Boymaw Fusion Transcripts
    XIANJIN ZHOU; Fiscal Year: 2010
    ..Three classic genetic studies on family aggregation, monozygotic twins, and adopted children revealed that there is a strong genetic contribution to the etiology of schizophrenia...
  12. Genetic Studies of Uterine Leiomyomata
    CYNTHIA CASSON MORTON; Fiscal Year: 2013
    ..Caucasian women (representing a serious health disparity) and twin-pair correlations for hysterectomy in monozygotic twins are about twice that observed in dizygous twins...
  13. Genetics, family environment, and neighborhood: impact on mental disorders
    JAN O SUNDQUIST; Fiscal Year: 2013
    ..genetics but not family environment) of at least one affected proband, further modeled in dizygotic and monozygotic twins using Structural Equation Modeling, 2) Compare the risk of psychiatric and substance use disorders in non-..
  14. Gene mutation and rescue in human diaphragmatic hernia
    Patricia K Donahoe; Fiscal Year: 2010
    ..deceased populations of patients, families with multiple affected members, consanguineous families, and monozygotic twins. DNA will be extracted from various sources for mutational analysis of candidate genes, arrayed based ..
  15. Genetic Studies of Interstitial Cystitis
    Louis M Kunkel; Fiscal Year: 2011
    ..underlying PBS/IC are unknown, but recurrence risks to siblings of affected individuals, concordance among monozygotic twins, and our own preliminary studies indicate a strong genetic contribution to the cause of PBS/IC...
  16. TWINStudy of Environment, Lifestyle Behaviors, and Health
    Glen E Duncan; Fiscal Year: 2013
    ..a study of environmental influences on lifestyle behaviors and health in a community-based sample of adult monozygotic twins who were reared together but now live apart...
  17. Mapping eQTLs that affect susceptibility to Tuberculosis
    Yoav Gilad; Fiscal Year: 2013
    ..factors contribute to inter-individual differences in susceptibility to TB, including the observation that monozygotic twins have considerably higher concordance rates for tuberculosis morbidity than do dizygotic twins...
  18. Imaging PTEN-induced changes in adult cortical structure and function in vivo
    Joshua Trachtenberg; Fiscal Year: 2012
    ..autism remains elusive, though a strong genetic contribution is evident from the 60%-92% concordance between monozygotic twins versus 0-10% in dizogtic twins...
  19. Metagenomic Analysis of the Structure and Function of the Human Gut Microbiota in
    Claire M Fraser; Fiscal Year: 2013
    ..on metagenomic and metaproteomic molecular tools to elucidate the composition of the commensal microbiota in monozygotic twins that are either healthy or exhibit Crohn's disease (for concordant, both are diseased;for discordant, ..
  20. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL E GERSHWIN; Fiscal Year: 2011
    ..We have support for the genetic basis of susceptibility based on data in monozygotic twins and prevalence in first-degree relatives...
  21. Validating a minimally-invasive assay to study the genomic fingerprint of stress
    Robert Plomin; Fiscal Year: 2012
    ..for clinical validation, we will ask a population-representative sample of 1,250 pairs of 16-year-old UK monozygotic twins followed-up by the Twins Early Development Study (TEDS) to complete a computerized version of the Perceived ..
  22. The role of retrotransposons in autism spectrum disorders
    Haig H Kazazian; Fiscal Year: 2010
    ..of somatic de novo L1 and Alu insertion in ASD patient genomes, ascertained through the study of discordant monozygotic twins, and 3...
  23. MAPPING GENES LINKED TO AUTOIMMUNE THYROID DISEASES
    Yaron Tomer; Fiscal Year: 2001
    ..g., the concordance rate in monozygotic twins is 75%)...
  24. Finding Genes for Uterine Fibroids
    Cynthia Morton; Fiscal Year: 2007
    ..least three times more frequent in black than in white women, and twin-pair correlations for hysterectomy in monozygotic twins are about twice that observed in dizygous twins. Studies of familial aggregation indicate a 2...
  25. DEVELOPMENTAL NEUROMORPHOMETRY IN YOUNG DEPRESSED TWINS
    Kelly Botteron; Fiscal Year: 2005
    ..In recent studies of monozygotic twins discordant for MDD, the investigators have demonstrated that 1) left SGPFC volume reduction in MDD is ..
  26. CONTROL MECHANISMS OF HEPATIC GLUCOSE OUTPUT
    John Clore; Fiscal Year: 2000
    ..has been designed to examine this hypothesis by comparing the effect of increased gluconeogenesis on HGO in monozygotic twins discordant for NIDDM to nondiabetic control subjects...
  27. Mentored Patient-Oriented Research Career Development Aw
    Mark Palmert; Fiscal Year: 2004
    ..The correlation between the timing of pubertal milestones among children and their parents and between monozygotic twins indicates that 48-80% of the variance in pubertal onset is genetically controlled...
  28. POSITIONAL CLONING STUDIES OF NARCOLEPSY GENES
    Emmanuel Mignot; Fiscal Year: 2000
    ..The importance of environmental factors can be illustrated by the fact that 25-31% of monozygotic twins reported in the literature are discordant for narcolepsy...
  29. Gluten Sensitivity in the Old Order Amish
    Daniel McBride; Fiscal Year: 2005
    ..the variable penetrance, 30%-50% concordance for GSE in HLA identical siblings, and near 100% concordance in monozygotic twins suggests a major patho-physiological role for additional gene loci...
  30. INTERACTIONAL FACTORS IN ANTISOCIAL BEHAVIOR
    Sarnoff Mednick; Fiscal Year: 1980
    ..The pairwise concordance rates for criminality for the monozygotic twins was 36%, for the dizygotic twins 13%...
  31. Metagenomic Analysis of the Structure and Function of the Human Gut Microbiota in
    Claire Fraser Liggett; Fiscal Year: 2009
    ..on metagenomic and metaproteomic molecular tools to elucidate the composition of the commensal microbiota in monozygotic twins that are either healthy or exhibit Crohn's disease (for concordant, both are diseased;for discordant, ..
  32. Microarrays & Proteomics in MZ Twins Discordant for CFS
    Patrick Sullivan; Fiscal Year: 2006
    ..The current plan is to correlate microarray and proteomic techniques to biological samples from monozygotic twins who are rigorously discordant for CFS...
  33. PATHOGENESIS OF TYPE I DIABETES IN MONOZYGOTIC TWINS
    JOHN SOELDNER; Fiscal Year: 1991
    ..The basic approach to understanding this problem has been longitudinal studies in sets of monozygotic twins discordant for IDDM...
  34. MOLECULAR AND CYTOGENETIC STUDIES OF UTERINE LEIOMYOMATA
    Cynthia Morton; Fiscal Year: 2002
    ..three times more frequent in Black than Caucasian women and the twin pair correlations for hysterectomy in monozygotic twins are about twice that observed in dizygous twins...
  35. Genetic Basis of chronic Multifocal Osteomyelitis
    Polly Ferguson; Fiscal Year: 2007
    ..1) There are reports of familial occurrence of the disease including affected siblings, concordance in monozygotic twins and a report of an affected father and child...
  36. GENERAL CLINICAL RESEARCH CENTER
    John Hutton; Fiscal Year: 1990
    ..members, an increased incidence of SLE among family members and a greater than 50% incidence of SLE among monozygotic twins. Other studies have suggested an environmental influence with the presence of lymphocytotoxic antibodies in ..
  37. CHRONIC FATIGUE SYNDROMECOOPERATIVE RESEARCH CENTERS
    Dedra Buchwald; Fiscal Year: 2002
    ..the objectives of the next period of support for this CFS CRC are to: 1) further characterize CFS using monozygotic twins discordant for CFS and to expose subjects to biological and behavior "stressors" in a theoretically guided ..
  38. Positional Cloning of a 6p-linked Asthma Gene
    Carole Ober; Fiscal Year: 2007
    ..S. alone. Familial aggregation and concordance rates in monozygotic twins have suggested a significant genetic component to asthma...
  39. Epigenesis of Cerebral Asymmetry in Twins
    Mark Eckert; Fiscal Year: 2004
    ..Central sulcus asymmetry will be studied as a non-language control measure. Monozygotic twins can also be studied to identify variables that produce phenotypic discordance...
  40. MEDICAL COLLEGE OF VA HUMAN TWIN PANEL--TWINNING BIOLOGY
    Walter Nance; Fiscal Year: 1980
    ..using a new model for the analysis of quantitative inheritance that involves the study of the descendants of monozygotic twins. The model will be extended to qualitative traits in a collaborative study with scientists at the University ..
  41. CHARACTERIZING A 5P-LINKED BHR SUSCEPTIBILITY LOCUS
    Carole Ober; Fiscal Year: 2004
    ..S. alone. Familial aggregation and concordance rates in monozygotic twins have suggested a genetic component to asthma...
  42. Identification and Characterization of Epigenetically Labile Genes
    Randy Jirtle; Fiscal Year: 2009
    Discordant phenotypes and varying incidences of complex diseases in monozygotic twins as well as genetically identical organisms have long been attributed to differential environmental exposures...
  43. SLEEP AND STARTLE IN PTSD DISCORDANT MONOZYGOTIC TWINS
    Richard Ross; Fiscal Year: 1999
    ....
  44. Axis I & Axis II Psychiatric Disorders in Norwegian Twin
    Kenneth Kendler; Fiscal Year: 2007
    ..This study has the capacity to address several key and largely unanswered empirical questions about PDs, the answers to which will be critical for proposed revisions in DSM-V. ..
  45. A Twin-Family Study of Drug Use, Abuse, and Dependence
    Kenneth Kendler; Fiscal Year: 2007
    ..abstract_text> ..
  46. BIOBEHAVIORAL MARKERS OF RISK FOR NICOTINE ADDICTION
    Andrey Anokhin; Fiscal Year: 2005
    ..The acquired expertise will allow the candidate to better integrate genetic and psychophysiological approaches in order to establish a program of interdisciplinary research in the neurobehavioral genetics of addiction. ..
  47. The Epidemiology of Mood, Anxiety and Alcohol Disorder
    Kenneth Kendler; Fiscal Year: 2004
    ....
  48. College Drinking: A Twin Study
    Andrey Anokhin; Fiscal Year: 2006
    ..This study will provide a greater understanding of the interplay of genetic and high-risk environmental factors in college drinking and can inform prevention and intervention strategies on college campuses. ..
  49. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2008
    ..In this competitive renewal, we request 5 further years of support with the primary goals of identifying these pathogenic variant(s) and relating them to the biology of the gene, gene product and disease. ..
  50. An Irish Affected Sib Pair Study of Alcohol Dependence
    Kenneth Kendler; Fiscal Year: 2005
    ..To conduct this project we have assembled a team of experts in clinical assessment, statistical genetics and molecular genetics...
  51. Preventing Psychiatric Sequelae of Traumatic Injury
    Murray Stein; Fiscal Year: 2003
    ..Findings will provide justification for and information about optimal parameters (e.g., subject selection; sample size; dose and duration) for a future randomized controlled trial (RCT). ..
  52. IMPROVING CARE FOR PANIC DISORDER IN PRIMARY CARE
    Murray Stein; Fiscal Year: 2002
    ..abstract_text> ..
  53. PHARMACOKINETICS OF NICOTINE IN TWINS
    Gary Swan; Fiscal Year: 2002
    ..Ultimately, this knowledge may lead to more informed and more finely targeted treatment of individuals who are either susceptible to nicotine addiction or are already addicted to this substance. ..
  54. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    ..This study will provide a new level of understanding for a complex birth defect trait. ..
  55. Improving Outcomes in Pharmacotherapy of Social Phobia
    Murray Stein; Fiscal Year: 2009
    ..It thus directly addresses a critical public health issue that adversely affects a substantial proportion of the population. ..
  56. Pharmacological fMRI to Identify New Anxiolytics: A Human Bioassay
    Murray Stein; Fiscal Year: 2008
    ..Enhancing the development of new treatments for anxiety is a public health priority. The projects proposed in this application have the potential to achieve this important aim. [unreadable] [unreadable] [unreadable]..
  57. Impact of Smoking Cessation on Sleep
    Gary Swan; Fiscal Year: 2008
    ..The results of this project will be particularly important for the development of targeted treatment approaches designed to ameliorate sleep disruption as part of an overall smoking cessation strategy. ..
  58. Treatment of Nicotine Dependence in Health Care Setting
    Gary Swan; Fiscal Year: 2009
    ....
  59. Biometric and Measured Genetic Research on Smoking
    Gary Swan; Fiscal Year: 2007
    ..Such knowledge will confer new insights about the etiology and progression of smoking and should improve the current understanding of smoking, which is still largely descriptive. ..
  60. CVD RISK FACTORS AND BRAIN MORPHOLOGY IN NHLBI TWINS
    Gary Swan; Fiscal Year: 2001
    ....
  61. Gene-Specific Responses to Exercise in Discordant Twins
    Paul Williams; Fiscal Year: 2007
    ..DNA samples will be shared with other institutions to cross-validate gene associations identified from training studies or other designs. ..
  62. Genetic Epidemiology of Pathological Gambling
    Wendy Slutske; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  63. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 2002
    ..1%). Additionally, a detectable reduction in breast cancer risk as small as 1.5% per mile run in women is calculated, which is below the 1.7% reduction in risk estimated from other published data. ..
  64. DNA METHYLOME STUDY IN TYPE 1 DIABETES
    ART PETRONIS; Fiscal Year: 2009
    ..In type 1 diabetes (T1D), epigenetic mechanisms can explain why 35% of monozygotic twins exhibit differential susceptibility to T1D, i.e...