frail elderly

Summary

Summary: Older adults or aged individuals who are lacking in general strength and are unusually susceptible to disease or to other infirmity.

Top Publications

  1. ncbi Frailty in older adults: evidence for a phenotype
    L P Fried
    Center on Aging and Health, The John Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 56:M146-56. 2001
  2. ncbi The assessment of frailty in older adults
    Gabor Abellan van Kan
    Gérontopôle de Toulouse, Department of Geriatric Medicine, Pavillon JP Junod, University Hospital Toulouse, CHU Toulouse, 170 avenue de Casselardit, TSA 40031, 31059 Toulouse Cedex 9, France
    Clin Geriatr Med 26:275-86. 2010
  3. ncbi The identification of frailty: a systematic literature review
    Shelley A Sternberg
    Maccabi Healthcare Services, Jerusalem, Israel
    J Am Geriatr Soc 59:2129-38. 2011
  4. ncbi Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care
    Linda P Fried
    Department of Medicine, The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 59:255-63. 2004
  5. pmc A global clinical measure of fitness and frailty in elderly people
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS
    CMAJ 173:489-95. 2005
  6. ncbi Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study
    Nancy Fugate Woods
    Seattle Clinical Center, Seattle, Washington 98195, USA
    J Am Geriatr Soc 53:1321-30. 2005
  7. pmc A standard procedure for creating a frailty index
    Samuel D Searle
    Geriatric Medicine Research Unit, Dalhousie University and Capital District Health Authority, Halifax, Canada
    BMC Geriatr 8:24. 2008
  8. ncbi Aging, frailty and age-related diseases
    T Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada
    Biogerontology 11:547-63. 2010
  9. ncbi Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study
    Upendram Srinivas-Shankar
    Andrology Research Unit, Department of Medicine and Endocrinology, University of Manchester, Manchester Royal Infirmary, Grafton Street, Manchester, United Kingdom M13 9WL
    J Clin Endocrinol Metab 95:639-50. 2010
  10. ncbi Phenotype of frailty: characterization in the women's health and aging studies
    Karen Bandeen-Roche
    Department of Biostatistics, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 61:262-6. 2006

Detail Information

Publications365 found, 100 shown here

  1. ncbi Frailty in older adults: evidence for a phenotype
    L P Fried
    Center on Aging and Health, The John Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 56:M146-56. 2001
    ..A standardized definition has not yet been established...
  2. ncbi The assessment of frailty in older adults
    Gabor Abellan van Kan
    Gérontopôle de Toulouse, Department of Geriatric Medicine, Pavillon JP Junod, University Hospital Toulouse, CHU Toulouse, 170 avenue de Casselardit, TSA 40031, 31059 Toulouse Cedex 9, France
    Clin Geriatr Med 26:275-86. 2010
    ..The evaluation of gait speed over a short distance emerges from the literature as a tool with the capacity to identify frail older adults, and slow gait speed has been proven to be a strong predictor for frailty-adverse outcomes...
  3. ncbi The identification of frailty: a systematic literature review
    Shelley A Sternberg
    Maccabi Healthcare Services, Jerusalem, Israel
    J Am Geriatr Soc 59:2129-38. 2011
    ..Important areas for further research include whether disability should be considered a component or an outcome of frailty. In addition, the role of cognitive and mood elements in the frailty construct requires further clarification...
  4. ncbi Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care
    Linda P Fried
    Department of Medicine, The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 59:255-63. 2004
    ....
  5. pmc A global clinical measure of fitness and frailty in elderly people
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS
    CMAJ 173:489-95. 2005
    ..We aimed to develop a tool that would be both predictive and easy to use...
  6. ncbi Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study
    Nancy Fugate Woods
    Seattle Clinical Center, Seattle, Washington 98195, USA
    J Am Geriatr Soc 53:1321-30. 2005
    ....
  7. pmc A standard procedure for creating a frailty index
    Samuel D Searle
    Geriatric Medicine Research Unit, Dalhousie University and Capital District Health Authority, Halifax, Canada
    BMC Geriatr 8:24. 2008
    ..A frailty index can be developed from most ageing databases. Our objective is to systematically describe a standard procedure for constructing a frailty index...
  8. ncbi Aging, frailty and age-related diseases
    T Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada
    Biogerontology 11:547-63. 2010
    ..The overall consequence is that frail elderly are at higher risk for accelerated physical and cognitive decline, disability and death...
  9. ncbi Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study
    Upendram Srinivas-Shankar
    Andrology Research Unit, Department of Medicine and Endocrinology, University of Manchester, Manchester Royal Infirmary, Grafton Street, Manchester, United Kingdom M13 9WL
    J Clin Endocrinol Metab 95:639-50. 2010
    ..Testosterone (T) increases muscle mass and strength in hypogonadal patients. It is unclear whether T has similar effects in intermediate-frail and frail elderly men with low to borderline-low T.
  10. ncbi Phenotype of frailty: characterization in the women's health and aging studies
    Karen Bandeen-Roche
    Department of Biostatistics, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 61:262-6. 2006
    ..This article evaluates the cross-validity, criterion validity, and internal validity in the Women's Health and Aging Studies (WHAS) of a discrete measure of frailty recently validated in the Cardiovascular Health Study (CHS)...
  11. ncbi Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women
    Anne M Kenny
    Center on Aging, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Am Geriatr Soc 58:1707-14. 2010
    ..To investigate the effects of dehydroepiandrosterone (DHEA) combined with exercise on bone mass, strength, and physical function in older, frail women...
  12. ncbi Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  13. ncbi Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
    Jeremy Walston
    Department of Medicine, Johns Hopkins Medical Institutions, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Am Geriatr Soc 54:991-1001. 2006
    ..This meeting and subsequent article were not meant to be a comprehensive review of frailty research; instead, they were and are meant to provide a more-targeted research agenda-setting process...
  14. ncbi Frailty in relation to the accumulation of deficits
    Kenneth Rockwood
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 2E1
    J Gerontol A Biol Sci Med Sci 62:722-7. 2007
    ..Future studies include the application of network analyses and stochastic analytical techniques to the evaluation of the frailty index and the description of other state variables in relation to frailty...
  15. ncbi Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, General Internal Medicine, Minneapolis, MN 55417, USA
    Arch Intern Med 168:382-9. 2008
    ..Frailty, as defined by the index derived from the Cardiovascular Health Study (CHS index), predicts risk of adverse outcomes in older adults. Use of this index, however, is impractical in clinical practice...
  16. ncbi Frailty defined by deficit accumulation and geriatric medicine defined by frailty
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Room 1421, 5955 Veterans Memorial Lane, Nova Scotia B3H 2E1, Canada
    Clin Geriatr Med 27:17-26. 2011
    ..Understanding people and their needs as deficits accumulate is an exciting challenge for clinical research on frailty and its management by geriatricians...
  17. pmc Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis
    Andrew D Beswick
    Department of Social Medicine, University of Bristol, Bristol, UK
    Lancet 371:725-35. 2008
    ..We did a systematic review to assess the effectiveness of community-based complex interventions in preservation of physical function and independence in elderly people...
  18. ncbi Outcome instruments to measure frailty: a systematic review
    N M de Vries
    Scientific Institute for Quality of Healthcare IQ Healthcare, Radboud University Nijmegen Medical Centre, P O Box 9101, 114, 6500 HB, Nijmegen, The Netherlands
    Ageing Res Rev 10:104-14. 2011
    ..Frailty instruments, however, are often developed as prognostic instruments and have also been validated as such. The clinimetric properties of these instruments as evaluative outcome measures are unclear...
  19. ncbi Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trial
    Michael Tieland
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    J Am Med Dir Assoc 13:720-6. 2012
    ..proposed as an effective dietary strategy to increase skeletal muscle mass and improve physical performance in frail elderly people...
  20. ncbi Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force
    G Abellan Van Kan
    Gerontopole, Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    J Nutr Health Aging 13:881-9. 2009
    ....
  21. ncbi Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study
    Jeremy Walston
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Arch Intern Med 162:2333-41. 2002
    ..The biological basis of frailty has been difficult to establish owing to the lack of a standard definition, its complexity, and its frequent coexistence with illness...
  22. pmc Protein intake and incident frailty in the Women's Health Initiative observational study
    Jeannette M Beasley
    Clinical Coordinating Center, Women s Health Initiative, Fred Hutchinson Cancer Research Center, Seattle, Washington 98101, USA
    J Am Geriatr Soc 58:1063-71. 2010
    ..To evaluate the association between protein intake and incident frailty...
  23. ncbi Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial
    Michael Tieland
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    J Am Med Dir Assoc 13:713-9. 2012
    ..Our objective was to assess the impact of protein supplementation on muscle mass, strength, and physical performance during prolonged resistance-type exercise training in frail elderly men and women.
  24. pmc Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey
    Kenneth Rockwood
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, NS
    CMAJ 183:E487-94. 2011
    ..Furthermore, less is known about how frailty changes over time among younger adults. We estimated the prevalence and outcomes of frailty, in relation to accumulation of deficits, across the adult lifespan...
  25. ncbi Prevalence of frailty in community-dwelling older persons: a systematic review
    Rose M Collard
    Department of Psychiatry, University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Am Geriatr Soc 60:1487-92. 2012
    ..To systematically compare and pool the prevalence of frailty, including prefrailty, reported in community-dwelling older people overall and according to sex, age, and definition of frailty used...
  26. ncbi The Tilburg Frailty Indicator: psychometric properties
    Robbert J J Gobbens
    Department of Tranzo Academic Centre for Transformation in Care and Welfare, Faculty of Behavioural and Social Sciences, Tilburg University, Tilburg, The Netherlands
    J Am Med Dir Assoc 11:344-55. 2010
    ..To assess the reliability, construct validity, and predictive (concurrent) validity of the Tilburg Frailty Indicator (TFI), a self-report questionnaire for measuring frailty in older persons...
  27. ncbi A systematic review of the benefits of home telecare for frail elderly people and those with long-term conditions
    James Barlow
    Tanaka Business School, Imperial College London, South Kensington Campus, London, UK
    J Telemed Telecare 13:172-9. 2007
    We have conducted a systematic review of home telecare for frail elderly people and for patients with chronic conditions...
  28. ncbi Loss of independence in activities of daily living in older adults hospitalized with medical illnesses: increased vulnerability with age
    Kenneth E Covinsky
    Division of Geriatrics, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 51:451-8. 2003
    ..To describe the changes in activities of daily living (ADL) function occurring before and after hospital admission in older people hospitalized with medical illness and to assess the effect of age on loss of ADL function...
  29. ncbi Frailty as a predictor of surgical outcomes in older patients
    Martin A Makary
    Department of Surgery, John Hopkins University School of Medicine, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    J Am Coll Surg 210:901-8. 2010
    ..We designed a study to determine if frailty predicts surgical complications and enhances current perioperative risk models...
  30. ncbi Effects of exercise programs on falls and mobility in frail and pre-frail older adults: A multicenter randomized controlled trial
    Marjan J Faber
    Faculty of Human Movement Sciences, Vrije University Amsterdam, Amsterdam, The Netherlands
    Arch Phys Med Rehabil 87:885-96. 2006
    ..To determine the effects of moderate intensity group-exercise programs on falls, functional performance, and disability in older adults; and to investigate the influence of frailty on these effects...
  31. ncbi Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, and Department of Medicine, University of Minnesota, Minneapolis, MN 55417, USA
    J Gerontol A Biol Sci Med Sci 62:744-51. 2007
    ..However, the predictive validity of this phenotype for fracture outcomes and across risk subgroups is uncertain...
  32. ncbi A program to prevent functional decline in physically frail, elderly persons who live at home
    Thomas M Gill
    Department of Internal Medicine, Yale University School of Medicine, Dorothy Adler Geriatric Assessment Center, New Haven, Conn 06504, USA
    N Engl J Med 347:1068-74. 2002
    ..Functional decline in physically frail, elderly persons is associated with substantial morbidity. It is uncertain whether such functional decline can be prevented...
  33. pmc Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries
    Brigitte Santos-Eggimann
    Department of Community Medicine and Health, Institute of Social and Preventive Medicine, University Hospital Center and University of Lausanne, Switzerland
    J Gerontol A Biol Sci Med Sci 64:675-81. 2009
    ..Its frequency has been described mainly for North America; comparable data from other countries are lacking. Here we report on the prevalence of frailty in 10 European countries included in a population-based survey...
  34. pmc Predicting ADL disability in community-dwelling elderly people using physical frailty indicators: a systematic review
    Joan Vermeulen
    School for Public Health and Primary Care CAPHRI, Maastricht University, Maastricht, The Netherlands
    BMC Geriatr 11:33. 2011
    Disability in Activities of Daily Living (ADL) is an adverse outcome of frailty that places a burden on frail elderly people, care providers and the care system...
  35. ncbi The frailty dilemma. Review of the predictive accuracy of major frailty scores
    Evelien Pijpers
    Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Eur J Intern Med 23:118-23. 2012
    To identify frail elderly individuals, several index or scoring systems have been developed for research purposes. The practical value of these scores for screening and diagnostic use is uncertain.
  36. ncbi Predictors of adverse outcomes on an acute geriatric rehabilitation ward
    Inderpal Singh
    Geriatric Medicine, University Hospital Llandough, Penlan Road, Llandough CF64 2XX, UK
    Age Ageing 41:242-6. 2012
    ..multidisciplinary rehabilitation is of proven benefit in the management of older inpatients. However, the identification of patients who will do well with rehabilitation currently lacks a strong evidence base...
  37. ncbi Role of frailty in patients with cardiovascular disease
    Jonathan Afilalo
    Division of Cardiology, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Cardiol 103:1616-21. 2009
    ..The role of frailty assessment in clinical practice may be to refine estimates of cardiovascular risk, which tend to be less accurate in the heterogenous elderly patient population...
  38. ncbi A procedure for creating a frailty index based on deficit accumulation in aging mice
    Randi J Parks
    Department of Pharmacology, Dalhousie University, 5850 College Street, Sir Charles Tupper Medical Building, Halifax, Nova Scotia, Canada B3H 1X5
    J Gerontol A Biol Sci Med Sci 67:217-27. 2012
    ..These results show that an FI can be developed for murine models and suggest that age-associated changes in myocytes are more prominent in animals with a high FI...
  39. pmc Effect of a multifactorial interdisciplinary intervention on mobility-related disability in frail older people: randomised controlled trial
    Nicola Fairhall
    Rehabilitation Studies Unit, Sydney Medical School, The University of Sydney, Ryde, 2112, Australia
    BMC Med 10:120. 2012
    ..Our objective was to assess the impact of a multifactorial intervention on mobility-related disability in frail older people...
  40. pmc Sharing clinical information across care settings: the birth of an integrated assessment system
    Leonard C Gray
    The University of Queensland, c Academic Unit in Geriatric Medicine, University Department of Medicine, Princess Alexandra Hospital, Brisbane, Australia
    BMC Health Serv Res 9:71. 2009
    ..Population ageing, the emergence of chronic illness, and the shift away from institutional care challenge conventional approaches to assessment systems which traditionally are problem and setting specific...
  41. pmc A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE)
    Roman Romero-Ortuno
    Department of Medical Gerontology Trinity College Dublin, Trinity Centre for Health Sciences, St James s Hospital, James s Street, Dublin 8, Ireland
    BMC Geriatr 10:57. 2010
    ..Our study is based on the first wave of the Survey of Health, Ageing and Retirement in Europe (SHARE, http://www.share-project.org), a large population-based survey conducted in 2004-2005 in twelve European countries...
  42. ncbi The frailty syndrome: a comprehensive review
    Roschelle A Heuberger
    Department of Human Environmental Studies, Central Michigan University, Mt Pleasant, Michigan 48859, USA
    J Nutr Gerontol Geriatr 30:315-68. 2011
    ..Evidence with respect to the clinical definition, epidemiology, mechanisms, interactions, assessment, prevention, and treatment of frailty in the older adult is reviewed...
  43. pmc Treating frailty--a practical guide
    Nicola Fairhall
    Rehabilitation Studies Unit, Faculty of Medicine, The University of Sydney, Ryde, Sydney 2112, Australia
    BMC Med 9:83. 2011
    ..We provide an evidence-based framework that can be used to guide the diagnosis, assessment and treatment of frail older people...
  44. ncbi Minimum data set for home care: a valid instrument to assess frail older people living in the community
    F Landi
    Istituto di Medicina Interna e Geriatria, Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    Med Care 38:1184-90. 2000
    Optimal care for frail elderly patients depends on comprehensive assessment. This is especially true in the complex setting of interdisciplinary home care programs...
  45. ncbi Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 53:2184-9. 2005
    ..To investigate the relationship between accumulated health-related problems (deficits), which define a frailty index in older adults, and mortality in population-based and clinical/institutional-based samples...
  46. pmc Prognostic significance of potential frailty criteria
    Marc D Rothman
    Department of Medicine, Division of Geriatrics, Yale University School of Medicine, New Haven, Connecticut 06504, USA
    J Am Geriatr Soc 56:2211-116. 2008
    ..To determine the independent prognostic effect of seven potential frailty criteria, including five from the Fried phenotype, on several adverse outcomes...
  47. ncbi The Vulnerable Elders Survey: a tool for identifying vulnerable older people in the community
    D Saliba
    RAND, Santa Monica, California 90401, USA
    J Am Geriatr Soc 49:1691-9. 2001
    ..Self-reported diagnoses and conditions, when added to the system, do not enhance predictive ability. The function-based targeting system relies on self-report and is easily transported across care settings...
  48. ncbi A comparison of two approaches to measuring frailty in elderly people
    Kenneth Rockwood
    Department of Medicine, Dalhousie University and Capital District Health Authority, Halifax, Nova Scotia, Canada, B3H 2E1
    J Gerontol A Biol Sci Med Sci 62:738-43. 2007
    ..Many definitions of frailty exist, but few have been directly compared. We compared the relationship between a definition of frailty based on a specific phenotype with one based on an index of deficit accumulation...
  49. pmc A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men
    Kristine E Ensrud
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 57:492-8. 2009
    ....
  50. pmc Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, low bone mass, and physical frailty
    Anne M Kenny
    Center on Aging, MC 5215, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Am Geriatr Soc 58:1134-43. 2010
    ..To investigate the effects of testosterone supplementation on bone, body composition, muscle, physical function, and safety in older men...
  51. pmc Frailty: an emerging research and clinical paradigm--issues and controversies
    Howard Bergman
    Division of Geriatric Medicine, Jewish General Hospital McGill University, 3755 Cote Ste Catherine, Montreal, QC, Canada H3T 1E2
    J Gerontol A Biol Sci Med Sci 62:731-7. 2007
    ..Although consensus has yet to be attained, work accomplished to date has opened exciting new horizons. The article concludes with suggested directions for future research...
  52. ncbi Vulnerability in the elderly: frailty
    Joris P J Slaets
    Department of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Med Clin North Am 90:593-601. 2006
    In scenarios that predict the future of health service delivery in the Western world, the rapid increase in frail elderly patients is seen as one of the major challenges of health care in addition to the care of the chronic medically ill...
  53. ncbi The MDS-CHESS scale: a new measure to predict mortality in institutionalized older people
    John P Hirdes
    Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada
    J Am Geriatr Soc 51:96-100. 2003
    ..To develop a scale predicting mortality and other adverse outcomes associated with frailty...
  54. ncbi Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation
    Xiaowei Song
    Department of Medicine, Dalhousie University, Halifax, Canada
    J Am Geriatr Soc 58:681-7. 2010
    ..To evaluate the prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation...
  55. ncbi Frailty in older men: prevalence, progression, and relationship with mortality
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
    J Am Geriatr Soc 55:1216-23. 2007
    ..To describe the association between frailty and health status, the progression of frailty, and the relationship between frailty and mortality in older men...
  56. ncbi Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test
    Mateu Serra-Prat
    Unidad de Investigacion, Consorci Sanitari del Maresme and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Am J Clin Nutr 89:1410-7. 2009
    ..Ghrelin and cholecystokinin (CCK) are among the peripheral signals that regulate hunger and satiety...
  57. ncbi What would make a definition of frailty successful?
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Age Ageing 34:432-4. 2005
    ..The need for progress on our understanding of frailty is evident, but for now, there is insufficient evidence to accept a single definition of frailty...
  58. ncbi Frailty, body mass index, and abdominal obesity in older people
    Ruth E Hubbard
    Geriatric Medicine Research Unit, Queen Elizabeth II Health Sciences Centre, 5955 Veterans Memorial Lane, Halifax, Canada, B3H 2E1
    J Gerontol A Biol Sci Med Sci 65:377-81. 2010
    ..We aimed to explore the relationship between frailty and body mass index (BMI) in older people...
  59. ncbi Prediction of adverse health outcomes in older people using a frailty index based on routine primary care data
    Irene Drubbel
    Julius Center for Health Sciences and Primary Care, Str 6 131, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    J Gerontol A Biol Sci Med Sci 68:301-8. 2013
    ..We investigated if a Frailty Index (FI) based on the routine health care data of GPs can predict the risk of adverse health outcomes in community-dwelling older people...
  60. ncbi Editorial: Something about frailty
    John E Morley
    J Gerontol A Biol Sci Med Sci 57:M698-704. 2002
  61. ncbi How should we grade frailty in nursing home patients?
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    J Am Med Dir Assoc 8:595-603. 2007
    ..To compare 3 methods of describing the frailty of older adults in nursing homes...
  62. ncbi In search of an integral conceptual definition of frailty: opinions of experts
    Robbert J J Gobbens
    Tranzo Academic Centre for Transformation in Care and Welfare, Tilburg University, Tilburg, The Netherlands
    J Am Med Dir Assoc 11:338-43. 2010
    ..The authors of this article fear that this could lead to fragmentation of care for frail older people. The aim is to develop an integral conceptual definition of frailty that starts from the premise of a holistic view of the person...
  63. ncbi Associations of subclinical cardiovascular disease with frailty
    A B Newman
    The University of Pittsburgh, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 56:M158-66. 2001
    ..Little work has been done to define frailty and describe the underlying pathophysiology...
  64. ncbi [Prevalence of frailty in an elderly Spanish urban population. Relationship with comorbidity and disability]
    María Victoria Castell Alcalá
    Centro de Salud Dr Castroviejo, Madrid, Espana
    Aten Primaria 42:520-7. 2010
    ..To estimate prevalence of frailty, by Fried criteria, in a Spanish urban old population, and to analyse relationship with comorbidity and disability...
  65. ncbi Low free testosterone predicts frailty in older men: the health in men study
    Zoe Hyde
    Western Australian Centre for Health and Ageing M570, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 95:3165-72. 2010
    ..The prevalence of frailty increases, whereas testosterone decreases, as men age. Low testosterone may be a risk factor for development of this syndrome...
  66. ncbi A limit to frailty in very old, community-dwelling people: a secondary analysis of the Chinese longitudinal health and longevity study
    Stephanie Bennett
    Geriatric Medicine Research Unit, Dalhousie University, Halifax, Nova Scotia, Canada
    Age Ageing 42:372-7. 2013
    ..it has been observed that a frailty index (FI) is limited by the value of 0.7. Whether this holds in countries with higher mortality rates is not known...
  67. pmc Frailty Intervention Trial (FIT)
    Nicola Fairhall
    Rehabilitation Studies Unit, Faculty of Medicine, The University of Sydney, Sydney Australia
    BMC Geriatr 8:27. 2008
    ..We aim to establish the effects of this intervention on frailty, mobility, hospitalisation and institutionalisation in frail older people...
  68. ncbi Frailty among community-dwelling elderly people in France: the three-city study
    José Alberto Avila-Funes
    Department of Geriatrics, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    J Gerontol A Biol Sci Med Sci 63:1089-96. 2008
    ..The purpose of this report is to show the characteristics of frailty and observe its prognosis in a large sample of French community-dwelling elderly persons...
  69. ncbi Toward a conceptual definition of frail community dwelling older people
    Robbert J Gobbens
    University of Applied Sciences, Breda, The Netherlands
    Nurs Outlook 58:76-86. 2010
    ..None of the current conceptual and operational definitions meet these criteria. In this article a new integral conceptual definition of frailty is proposed which meets the criteria of a successful definition...
  70. ncbi Effect of telephone exercise counseling on frailty in older veterans: project LIFE
    Matthew J Peterson
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Durham, NC 27705, USA
    Am J Mens Health 1:326-34. 2007
    ..07). There was a clinically meaningful change in frailty status with intensive, telephone exercise counseling. Improvement in frailty status was likely due to improvement in functional limitations...
  71. ncbi Prevention of adverse health trajectories in a vulnerable elderly population through nurse home visits: a randomized controlled trial [ISRCTN05358495]
    Hein P J van Hout
    Department of General Practice, EMGO Institute, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 65:734-42. 2010
    ..Can indicative prevention of home-visiting nurses be effective when targeted at a frail senior population using multidimensional geriatric assessments and personalized care plans?..
  72. ncbi Outcomes of coordinated and integrated interventions targeting frail elderly people: a systematic review of randomised controlled trials
    Kajsa Eklund
    The Vardal Institute, The Swedish Institute for Health Sciences, Lund University, Lund, Sweden
    Health Soc Care Community 17:447-58. 2009
    ..of this study was to review randomised controlled trials on integrated and coordinated interventions targeting frail elderly people living in the community, their outcome measurements and their effects on the client, the caregiver and ..
  73. ncbi The functional effects of physical exercise training in frail older people : a systematic review
    Marijke J M Chin A Paw
    Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands
    Sports Med 38:781-93. 2008
    ....
  74. ncbi Preventive home care of frail older people: a review of recent case management studies
    Ingalill Rahm Hallberg
    Department of Nursing Care, Lund University, Sweden
    J Clin Nurs 13:112-20. 2004
    ..Perhaps effects would be expected in all three areas and thus these should be included in evaluative studies in addition to measures for family and/or informal caregiver's strain and satisfaction...
  75. ncbi The challenges of clinical trials in the exclusion zone: the case of the frail elderly
    Iman Ridda
    The Children Hospital, National Center for Immunisation Research and Surveillance, Westmead, New South Wales, Australia
    Australas J Ageing 27:61-6. 2008
    ....
  76. ncbi A randomized study of a multidisciplinary program to intervene on geriatric syndromes in vulnerable older people who live at home (Dutch EASYcare Study)
    René J F Melis
    Radboud University Nijmegen Medical Centre, Department of Geriatric Medicine, Nijmegen, The Netherlands
    J Gerontol A Biol Sci Med Sci 63:283-90. 2008
    ..This study compared the effects of this new model to usual care...
  77. pmc Long-term effect on mortality of a home intervention that reduces functional difficulties in older adults: results from a randomized trial
    Laura N Gitlin
    Jefferson Center for Applied Research on Aging and Health, Thomas Jefferson University, Philadelphia, Pennsylvania 19130, USA
    J Am Geriatr Soc 57:476-81. 2009
    ..To evaluate the long-term mortality effect of a home-based intervention previously shown to reduce functional difficulties and whether survivorship benefits differ according to initial mortality risk level...
  78. ncbi Effects of food fortification on nutritional and functional status in frail elderly nursing home residents at risk of malnutrition
    Christine Smoliner
    Medizinische Klinik mit Schwerpunkt Gastroenterologie, Hepatologie und Endokrinologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Nutrition 24:1139-44. 2008
    ..In this study we evaluated the effect of a 12-wk nutritional intervention with fortified food on nutritional and functional status in nursing home residents at risk of malnutrition...
  79. ncbi Effects of case management for frail older people or those with chronic illness: a systematic review
    Barth Oeseburg
    Department of Health Sciences, Graduate School for Health Research, Wenckebach Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Nurs Res 58:201-10. 2009
    ..Financial constraints and quality requirements demand that interventions selected are most effective. A previous systematic review of the effectiveness of the patient advocacy case management model was not found...
  80. ncbi Life course social and health conditions linked to frailty in Latin American older men and women
    Beatriz E Alvarado
    Department of Epidemiology, McGill University, Montreal QC H3A 1A2, Canada
    J Gerontol A Biol Sci Med Sci 63:1399-406. 2008
    ....
  81. ncbi Prevention of falls in older patients
    Shobha S Rao
    Department of Family Practice and Community Medicine, University of Texas Southwestern, Dallas, Texas 75390 9067, USA
    Am Fam Physician 72:81-8. 2005
    ..Home hazard assessment and modification by a health professional also is helpful...
  82. ncbi Missing links in oral health care for frail elderly people
    Michael I Macentee
    Division of Prosthodontics and Dental Geriatrics, Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver
    J Can Dent Assoc 72:421-5. 2006
    A national interdisciplinary strategy is needed to address the comprehensive oral health care needs of frail elderly people residing in long-term care facilities...
  83. pmc Reduced health-related quality of life in elders with frailty: a cross-sectional study of community-dwelling elders in Taiwan
    Cheng Chieh Lin
    Department of Family Medicine, China Medical University and Hospital, Taichung, Taiwan
    PLoS ONE 6:e21841. 2011
    ..This association has not been investigated in community-dwelling elders. Therefore, we examined the domains and degree of HRQOL of elders with frailty in the community in Taiwan...
  84. ncbi Frail elderly patients in primary care--their medication knowledge and beliefs about prescribed medicines
    Sara Modig
    Department of Clinical Sciences in Malmo, General Practice Family Medicine, Lund University, Lund, Sweden
    Eur J Clin Pharmacol 65:151-5. 2009
    ..The aim of this study was to describe elderly patients' knowledge about and attitudes towards their medicines in Swedish primary care...
  85. ncbi A conceptual framework of frailty: a review
    Walter M Bortz
    Stanford University School of Medicine, California, USA
    J Gerontol A Biol Sci Med Sci 57:M283-8. 2002
    ..As such, the state of frailty is largely separable from the process of aging and should thereby be susceptible to active intervention and reversal...
  86. ncbi Frailty and its association with disability and comorbidity in a community-dwelling sample of seniors in Montreal: a cross-sectional study
    Chek Hooi Wong
    McGill University of Montreal Solidage Research Group, Montreal, Canada
    Aging Clin Exp Res 22:54-62. 2010
    ....
  87. ncbi Perspectives of elderly people receiving home help on health, care and quality of life
    Y Hellström
    Department of Science and Health, Blekinge Institute of Technology, SE 371 79 Karlskrona, Sweden
    Health Soc Care Community 9:61-71. 2001
    ..Multiple linear regression analysis showed the number of complaints, restricted ability to be alone, living alone and age to have a significant relationship on low quality of life...
  88. ncbi The prevalence of frailty syndrome in an older population from Spain. The Toledo Study for Healthy Aging
    F J Garcia-Garcia
    Division of Geriatric Medicine, Hospital Virgen del Valle, Complejo Hospitalario de Toledo, Toledo, Spain
    J Nutr Health Aging 15:852-6. 2011
    ..To assess the prevalence of the frailty syndrome and its associated variables among the older adult population in the province of Toledo (Spain)...
  89. ncbi Variability in measuring (instrumental) activities of daily living functioning and functional decline in hospitalized older medical patients: a systematic review
    Bianca M Buurman
    Department of Internal Medicine and Geriatrics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Epidemiol 64:619-27. 2011
    ..To study instruments used and definitions applied in order to measure (instrumental) activities of daily living (I [ADL]) functioning and functional decline in hospitalized older medical patients...
  90. ncbi Using assessing care of vulnerable elders quality indicators to measure quality of hospital care for vulnerable elders
    Vineet M Arora
    Section of General Internal Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA
    J Am Geriatr Soc 55:1705-11. 2007
    ..To assess the quality of care for hospitalized vulnerable elders using measures based on Assessing Care of Vulnerable Elders (ACOVE) quality indicators (QIs)...
  91. ncbi Gait velocity and the Timed-Up-and-Go test were sensitive to changes in mobility in frail elderly patients
    Marianne B van Iersel
    Department of Geriatrics, Radboud University Nijmegen Medical Centre, Internal code 925, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Epidemiol 61:186-91. 2008
    To estimate clinically relevant changes in functional mobility tests and quantitative gait measures at group and individual level in frail elderly patients.
  92. ncbi Evaluating the older patient with cancer: understanding frailty and the geriatric assessment
    Sumanta Kumar Pal
    Division of Genitourinary Malignancies, Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    CA Cancer J Clin 60:120-32. 2010
    ..This review describes key studies from the geriatric literature that provide principles for assessing health status in the older patient, and ways that these principles can be applied to oncology care in an older population are proposed...
  93. ncbi The presence of frailty in elderly persons with chronic renal insufficiency
    Michael G Shlipak
    Epidemiology and Biostatistics, University of California, San Francisco, General Internal Medicine Section, Medical Service, San Francisco Veterans Affairs Medical Center San Francisco, CA 94121, USA
    Am J Kidney Dis 43:861-7. 2004
    ..We hypothesized that chronic renal insufficiency (CRI) would be associated with a greater prevalence of frailty and disability in the elderly...
  94. ncbi Evaluation of a frailty index based on a comprehensive geriatric assessment in a population based study of elderly Canadians
    David Jones
    Faculty of Medicine, Memorial University, St John s, Canada
    Aging Clin Exp Res 17:465-71. 2005
    ..Objectives were to develop a frailty index (FI) based on a standard comprehensive geriatric assessment (CGA) derived from a clinical examination; to assess the validity of the FI-CGA and to compare its precision with other frailty measures...
  95. pmc The frailty syndrome: definition and natural history
    Qian Li Xue
    Department of Medicine, Johns Hopkins University School of Medicine, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205 1179, USA
    Clin Geriatr Med 27:1-15. 2011
    ....
  96. pmc Dimensions and correlates of quality of life according to frailty status: a cross-sectional study on community-dwelling older adults referred to an outpatient geriatric service in Italy
    Claudio Bilotta
    Department of Internal Medicine, Geriatric Medicine Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    Health Qual Life Outcomes 8:56. 2010
    ..The aim of this study was to investigate dimensions and correlates of QOL associated with frailty status among community-dwelling older outpatients...
  97. ncbi Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project
    Stephane Rochat
    Service of Geriatric Medicine and Geriatric Rehabilitation, University of Lausanne Hospital Center, Lausanne, Switzerland
    Age Ageing 39:228-33. 2010
    ..The associations between frailty and use of specific health and community services have not been investigated...
  98. pmc Frailty: an emerging concept for general practice
    Jan De Lepeleire
    Katholieke Universiteit Leuven, Belgium
    Br J Gen Pract 59:e177-82. 2009
    ....
  99. ncbi "They do what they think is the best for me." Frail elderly patients' preferences for participation in their care during hospitalization
    Anne W Ekdahl
    Geriatric Department, Vrinnevi Hospital, Norrkoping, Sweden Department of Social and Welfare Studies, Faculty of Health Sciences, Linkoping University, Norrkoping, Sweden
    Patient Educ Couns 80:233-40. 2010
    To deepen the knowledge of frail elderly patients' preferences for participation in medical decision making during hospitalization.
  100. pmc Frailty and the degradation of complex balance dynamics during a dual-task protocol
    Hyun Gu Kang
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 64:1304-11. 2009
    ..We hypothesized that COP dynamics from frail elderly individuals demonstrate less complexity than those from nonfrail elderly controls; complexity decreases when ..
  101. ncbi Aging, disability and frailty
    Eva Topinkova
    Department of Geriatrics, 1st Faculty of Medicine, Charles University in Prague, and Institute of Postgraduate Medical Education, Prague, Czech Republic
    Ann Nutr Metab 52:6-11. 2008
    ..In the article, current recommendations for future research strategies of frailty syndrome will be discussed...

Research Grants66

  1. Testosterone Therapy After Hip Fracture in Elderly Women
    ELLEN BINDER; Fiscal Year: 2005
    ..role of testosterone therapy for improving deficits in muscle mass, strength, and functional capacity in the frail elderly is unclear, particularly for elderly women...
  2. Maintenance of Skeletal Integrity in Frail Elders
    Susan L Greenspan; Fiscal Year: 2013
    ..abstract_text> ..
  3. Oral Health Disparities Among Medicaid Beneficiaries
    Sujha Subramanian; Fiscal Year: 2010
    ..limited information on the burden of oral and pharyngeal cancers for specials needs populations, including the frail elderly, the disabled, and those with AIDS/HIV...
  4. Nanotechnology-based Theranostic Technology for Bone Tissue Engineering
    Balaji Sitharaman; Fiscal Year: 2010
    ..g., frail elderly, spinal cord injury, confined to wheelchairs or bed-rest, experience space travel) during treatment...
  5. AGS Guiding Principles for the Care of Older Adults with Multimorbidity: A Mobile
    Nancy Lundebjerg; Fiscal Year: 2013
    ..the project, including overall success of our outreach efforts to promote awareness, tracking usage of the MGP App &Online Educational Tools, and the overall feedback on the MGP app as well as an evaluation of its effectiveness ..
  6. COMBINING TESTOSTERONE THERAPY AND EXERCISE TO IMPROVE FUNCTION POST HIP FRACTURE
    Kenneth B Schechtman; Fiscal Year: 2013
    ..role of testosterone therapy for improving deficits in muscle mass, strength, and functional capacity in the frail elderly is unclear, particularly for elderly women...
  7. Prevention of Nosocomial Infections and Cost Effectiveness in Nursing Homes
    Patricia W Stone; Fiscal Year: 2013
    ..6 million Americans live in the nation's 16,000 nursing homes (NHs) and the "frail elderly" account for 90% of the residents...
  8. Regulatory Role of Growth Hormone Secretagogue Receptor
    Roy G Smith; Fiscal Year: 2012
    ..MK-0677 rejuvenated the growth hormone (GH) axis in the frail elderly which was accompanied by increased bone density, lean mass and strength...
  9. Nutritional and Contractile Regulation of Muscle Growth
    Blake B Rasmussen; Fiscal Year: 2012
    ..g., in patients undergoing physical therapy following surgery, frail elderly, orthopedic patients, etc...
  10. PACTTE-Partnership for Anemia: Clinical and Translational Trials in the Elderly
    Harvey Jay Cohen; Fiscal Year: 2012
    ..among older adults occurring in over 10% of community dwelling older persons and exceeding 50% among the frail elderly. A consistent and independent relationship exists between anemia and a heightened risk of adverse consequences ..
  11. Comparing Interventions to Improve the Well-Being of Custodial Grandfamilies
    Gregory C Smith; Fiscal Year: 2013
    ..This application is also consistent with the NIH belief that "development of interventions based on well-defined underlying mechanisms is critical to advancing health promotion and diseases prevention." ..
  12. Nonlinear Dynamics of Frailty in Aging
    Lewis Lipsitz; Fiscal Year: 2013
    ..We will also determine whether interactions between these systems degrade in frail elderly individuals by examining the correlations, coherence, phase, and transfer function gains between the dynamic ..
  13. Evaluation and Integration of an Automatic Fall Prediction System
    William D Kearns; Fiscal Year: 2010
    ..Keywords: everyday movements, gait, balance, falls, falls risk, Ultrawideband location aware data, frail elderly.
  14. Ghrelin and Strength Training in Frail Elderly
    Anne R Cappola; Fiscal Year: 2012
    ..Our study will provide essential data to refine a future clinical trial to test ghrelin and resistance training as a joint intervention to improve the health and function of individuals with frailty. ..
  15. Functional Outcomes After Major Surgery in Nursing Home Residents
    Emily Finlayson; Fiscal Year: 2010
    ..outcomes in order to know when to refer a patient for surgery and when it is appropriate to operate on a frail elderly patient...
  16. Translational meta-analysis for elderly lung cancer patients
    Xiaofei Wang; Fiscal Year: 2013
    ....
  17. Cost-Sharing, Use, and Outcomes of Post-Acute Care in Medicare Advantage Plans
    Amal N Trivedi; Fiscal Year: 2013
    ..can inform optimal Medicare benefit policies that promote better health outcomes and the appropriate use of post acute services while minimizing negative unintended consequences for frail elderly and the Medicare program budget.
  18. Higher Order Measurement Invariance and Aging Research
    John R Nesselroade; Fiscal Year: 2010
    ..The results can then be used for more effective diagnosis, selection, and classification procedures in dealing with both well and impaired individuals, including the frail elderly.
  19. Assessing preferences for everyday living in the nursing home: reliability and co
    KIMBERLY S VANHAITSMA; Fiscal Year: 2012
    ..Exploratory aim: Examine the concordance between resident-rated preferences and family member proxy ratings of resident preferences. ..
  20. A Short Instrumented Test of Mobility for Neurological Disorders
    FAY BAHLING HORAK; Fiscal Year: 2013
    ..disability, such as multiple sclerosis, stroke, head injury, developmental disorders, multisensory deficits, frail elderly, etc. This Phase I application will determine the feasibility of the ISAW test...
  21. Center for Education and Research on Mental Health Ther*
    Stephen Crystal; Fiscal Year: 2010
    ..Initiative;Reducing the Duration Gap to Improve Adult Schizophrenia Outcomes;Improving Psychotropic Use Among Frail Elderly and Adults with Medical Illnesses;Furthering Guideline-Consistent Management of Antidepressant Treatment in ..
  22. Optimizing vitamin D in the elderly
    Janice B Schwartz; Fiscal Year: 2013
    ..data available show marked inter-individual variability in response to vitamin D supplementation in very old, frail elderly wih almost 25% remaining vitamin D deficient (25-OH D <20 ng/mL) when receiving the currently recommended ..
  23. Communication Processes for Accountable Care Enhancement (C-PACE)
    RUSSELL CHARLES MAULITZ; Fiscal Year: 2013
    ..C-PACE can rewrite the rule-book by taking what's always been "under the radar" -- care-coordination -- and making it visible, well-supported, and accountable. ..
  24. Consequences of Drug Cost Sharing:A New Randomized Trial
    Sebastian Schneeweiss; Fiscal Year: 2006
    ..It should further provide a set of refined tools describing how to plan, implement, and execute drug cost-saving measures, including a pre-policy impact-simulation software. ..
  25. Home Objective Mobility Exam (HOME) for Balance and Gait Disorders in Parkinson's
    FAY BAHLING HORAK; Fiscal Year: 2013
    ..disability, such as multiple sclerosis, stroke, head injury, developmental disorders, multisensory deficits, frail elderly, etc...
  26. Negotiating Sexuality and Intimacy of Older Adults in Assisted Living
    ELISABETH BURGESS; Fiscal Year: 2009
    ..supportive housing for older adults, intended to prevent or delay nursing home placement for a rapidly growing frail elderly population...
  27. AN INVESTIGATION OF THE VIATICAL SETTLEMENTS MARKET
    Dana Goldman; Fiscal Year: 2005
    People near the end of life such as the frail elderly or terminally ill often desire to sell non-liquid assets to finance current consumption...
  28. Selection and the Quality Impact of Nursing Home Ownership
    David C Grabowski; Fiscal Year: 2010
    ..By examining this relationship using a novel empirical strategy, this study provides an opportunity to improve the quality of care for the millions of Americans receiving care in the nursing home setting. ..
  29. ATTENUATION OF MUSCLE WASTING WITH GROWTH HORMONE
    Herman Vandenburgh; Fiscal Year: 2000
    ..This was especially true for slow-twitch muscle which may be important for maintaining postural muscles in the frail elderly. In Phase II, we will extend the scientific program to isolate, grow, genetically engineer, and tissue ..
  30. SOCIAL-COGNITIVE FUNCTIONING IN AGING AND DEMENTIA
    Allyson Washburn; Fiscal Year: 1999
    ..The goals are, first, to determine whether social behavior in the frail elderly can be feasibly and reliably assessed in natural settings; and second, to examine the psychometric properties ..
  31. Informal Care of Older Adults and Medicare Expenditures
    COURTNEY VAN HOUTVEN; Fiscal Year: 2003
    ..Ultimately informal care a effects the health status of the frail elderly, their ability to live independently, and expenditures on health care...
  32. LIFE-SPAN DEVELOPMENT--MECHANISMS OF EVERYDAY COGNITION
    HAYNE REESE; Fiscal Year: 1990
    ..in relation to public health, especially as its findings will bear on the ability of health workers to assist frail elderly adults in their daily activities...
  33. WASHINGTON UNIVERSITY CLAUDE D PEPPER OAIC
    John Holloszy; Fiscal Year: 2001
    ..have been shown to occur in younger individuals, and b) to assess whether the adaptations to exercise in the frail elderly are sufficiently large and functionally important to result in a significant reversal of frailty...
  34. Patient Transfer - Pressure Reducing Overlay (PtPRO)
    Jeffrey Jensen; Fiscal Year: 2003
    ..There is tremendous opportunity to improve care. EXAMPLE: Picture a frail elderly lady who falls at home and breaks her hip. At the ER, she is transferred to the ER gurney/bed...
  35. Pilot Study of Assisted Living Facilities in Florida
    Jill Quadagno; Fiscal Year: 2002
    ..indicates that ALF placement may be an appropriate substitute for nursing home admission,, for at least some frail elderly people...
  36. STRUCTURE, PROCESS AND OUTCOMES IN THE PACE PROGRAM
    Dana Mukamel; Fiscal Year: 2003
    ..Program of All-Inclusive Care for the Elderly (PACE) is a community-based alternative to nursing home care for frail elderly who have significant functional and/or cognitive impairments...
  37. Bioterrorism Preparedness in Rural and Urban Communities
    Aram Dobalian; Fiscal Year: 2003
    ..abstract_text> ..
  38. Nutritional Status of Community Dwelling Elders
    CHERYL CHEN; Fiscal Year: 2003
    ..abstract_text> ..
  39. HEALTH EDUCATION IN AN HMO--EFFECTIVENESS AND EFFICIENCY
    RONALD TOSELAND; Fiscal Year: 1999
    ..at Albany proposes to examine the short- and long-term effectiveness of a health education program (HEP) for frail elderly and their spouse caregivers...
  40. FICSIT COLLABORATIVE ANALYSES
    MARIA FIATARONE; Fiscal Year: 1993
    Muscle weakness and mobility impairment are important risk factors for falls in the frail elderly. Marked decreases in muscle strength may be attributable to: 1) biological changes of aging, 2) acute and chronic diseases, 3) sedentary ..
  41. Biomechanical Causes of Slow Gait in the Elderly
    DARRYL THELEN; Fiscal Year: 2006
    ..Reduced strength and diminished aerobic capacity are commonly proposed causes for slow walking. Frail elderly adults can often make significant improvements in muscle strength and endurance through exercise...
  42. Health Information Technology in the Nursing Home
    Jerry Gurwitz; Fiscal Year: 2006
    ..interest to AHRQ with special relevance to the delivery of high-quality care to a priority population--the frail elderly patient population residing in nursing homes...
  43. COMPREHENSIVE OUTCOMES OF FRAIL ELDERS IN THE COMMUNITY
    Kenneth Covinsky; Fiscal Year: 2004
    ..abstract_text> ..
  44. Care monitor system to facilitate pressure ulcer prevention for the elderly
    Mark Friedman; Fiscal Year: 2009
    ..Most of the physical body care of the ill or frail elderly in institutions - especially long term care - is provided by nursing aides and other clinical ..
  45. Testing a Functional Approach to Subacute Rehabilitation
    David Nelson; Fiscal Year: 2003
    ..Hip fracture, frequently occurring in frail elderly persons with multiple health problems, is one of the most important diagnoses in this setting...
  46. Information Solutions for Community Long Term Care
    RICK ZAWADSKI; Fiscal Year: 2002
    ..MSSP serves approximately 10,000 frail elderly individuals in California at 1 sites with a 25% expansion currently budgeted...
  47. Work-family Conflict and Drinking in Caregivers
    KATHLEEN ROSPENDA; Fiscal Year: 2009
    ..use/misuse over time in employed people who are also unpaid caregivers of children, dependent adults, or frail elderly. Goals are to examine: 1) Antecedents of WFC in work (e.g...
  48. EFFECTS OF A NURSING-BASED INTERVENTION IN TWO EDS
    Robert Palmer; Fiscal Year: 2000
    ..awarded Robert Wood Johnson clinical demonstration grant (SIGNET), based in the ED, aimed at maintaining frail elderly in the community setting...
  49. VISUAL IMPAIRMENT AND FUNCTIONAL STATUS IN FRAIL ELDERLY
    BRENDA KELLER; Fiscal Year: 2001
    ..The candidate will also study clinical teaching techniques and learn administrative aspects of medical direction in nursing facilities. ..
  50. Medication Dispenser: MD2: Improving Health Outcomes
    ANIL SAHAI; Fiscal Year: 2007
    ..The need to improve medication management, among the frail elderly, via such technologic innovation as the MD 2 needs to be more formally studied through a randomized clinical ..
  51. FALL BIOMECHANICS AND HIP FRACTURE RISK
    Wilson Hayes; Fiscal Year: 2004
    ..are characterized by increased regularity of heartbeat and gait, respectively, we will determine if gait parameters determined from ground pressure time histories can be used to identify frail elderly subjects who fall to the side.
  52. PREDOCTORAL FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    RACHEL COWAN; Fiscal Year: 2007
    Current Medicare policy unnecessarily limits the mobility of the frail elderly by funding purchases of inappropriate manual wheelchairs...
  53. After Discharge management of Low Income Frail Elderly
    Kyle Allen; Fiscal Year: 2007
    ..Use of this model to deliver healthcare services seems especially appropriate with frail elderly as a method to increase access to the expertise of the relatively few trained Geriatricians with the numerous ..
  54. INTERVENTIONS FOR VISUAL LOSS IN NURSING HOME RESIDENTS
    Sheila West; Fiscal Year: 2002
    ..This trial will answer timely questions of the impact on the functional status of the most frail elderly of modest, potentially sustainable inputs into improving the appropriate utilization of eye care services.
  55. ORAL CONDITIONS AND HEALTH OUTCOMES IN FRAIL ELDERS
    Michelle Henshaw; Fiscal Year: 2004
    ..abstract_text> ..
  56. Project ASSIST for Chronic Illness Caregivers
    Linda Davis; Fiscal Year: 2006
    ..A final sample size of 142 will yield a power of .81 for finding moderate multivariate effects, using p = .025. [unreadable] [unreadable]..
  57. IRC FOR THE STUDY OF LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2009
    ..prevention or delay of cognitive impairment in depressed elderly;and the rehabilitation of medically frail elderly with depressive illness, such as those with MI or hip fracture;2) improving treatment of difficult to treat ..
  58. DEMENTIA/CARDIAC SYMPTON MANAGEMENT BY FAMILY
    MARGARET PERKINSON; Fiscal Year: 2001
    ..Insight into the factors influencing caregivers' responses to symptoms of their impaired relatives may facilitate a more collaborative relation between caregivers and health professionals. ..
  59. Home Care Medication Management for the Frail Elderly
    Scott J Adams; Fiscal Year: 2010
    ..If medication management machines can be shown to be safe and effective, quality of life will be improved and unnecessary nursing home admissions, hospitalizations, and emergency department visits may be prevented. ..
  60. EFFECT OF FORMAL HOME CARE SERVICES ON CAREGIVER BURDEN
    Andrea Weiner; Fiscal Year: 2000
    This proposal will provide a better understanding of the dynamics of family caregiving to low income and frail elderly individuals living in the community, as well as to test the ability of a program enrolling Medicare- and Medicaid-..
  61. Physiological Stress and Health Outcomes in Frail Elder*
    Vicki Freedman; Fiscal Year: 2001
    ..link between physiological reactions to stress and subsequent health outcomes among physically and cognitively frail elderly persons...
  62. ASSISTED LIVING AND HEALTH SYSTEM USE
    Charles Phillips; Fiscal Year: 2001
    ..hope, there is relatively little empirical information about the role ALFs play in meeting the needs of the frail elderly. In addition, there is no information about the effects of variations among ALF organizational features that ..
  63. Placement Decisions for Relatives with Dementia
    BETTY WINSLOW; Fiscal Year: 2002
    ..abstract_text> ..
  64. BABY-BOOMERS & HEALTH CARE NEEDS OF ELDERLY PARENTS
    Martha Hill; Fiscal Year: 2000
    ..is centered on both actual changes in work hours and in the children's reports about whether assisting frail elderly parents meant changing work hours...
  65. Nursing Rehab Program for Post-Hospitalized NH Residents
    Victoria Grando; Fiscal Year: 2003
    ..abstract_text> ..
  66. EXTENDING A PERFORMANCE EVALUATION FOR GERONTOLOGY
    Anne Fisher; Fiscal Year: 2000
    ..ADL tasks will be calibrated on a quota sample of 1000 young and older adults that represent the well to frail elderly continuum, and with equal representation for gender and proportional representation for race (black/white)...