adult

Summary

Summary: A person having attained full growth or maturity. Adults are of 19 through 44 years of age.

Top Publications

  1. doi Cancer statistics, 2010
    Ahmedin Jemal
    Cancer Surveillance, Surveillance and Health Policy Research, American Cancer Society, Atlanta, GA 30303 1002, USA
    CA Cancer J Clin 60:277-300. 2010
  2. doi Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    Jacques Ferlay
    Section of Cancer Information, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 127:2893-917. 2010
  3. ncbi Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    D R Matthews
    Diabetologia 28:412-9. 1985
  4. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
  5. doi Prevalence and trends in obesity among US adults, 1999-2008
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4315, Hyattsville, MD 20782, USA
    JAMA 303:235-41. 2010
  6. doi Cancer statistics, 2012
    Rebecca Siegel
    Surveillance Research, American Cancer Society, Atlanta, GA 30303 1002, USA
    CA Cancer J Clin 62:10-29. 2012
  7. ncbi Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell 126:663-76. 2006
  8. pmc A core gut microbiome in obese and lean twins
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 457:480-4. 2009
  9. doi Global estimates of the prevalence of diabetes for 2010 and 2030
    J E Shaw
    Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes Res Clin Pract 87:4-14. 2010
  10. pmc A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009

Research Grants

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
  2. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
  3. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
  4. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
  5. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
  6. Noreen F Rossi; Fiscal Year: 2016
  7. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
  8. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
  9. BRIAN JAMES MCMAHON; Fiscal Year: 2016
  10. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012

Detail Information

Publications333 found, 100 shown here

  1. doi Cancer statistics, 2010
    Ahmedin Jemal
    Cancer Surveillance, Surveillance and Health Policy Research, American Cancer Society, Atlanta, GA 30303 1002, USA
    CA Cancer J Clin 60:277-300. 2010
    ..Further progress can be accelerated by applying existing cancer control knowledge across all segments of the population and by supporting new discoveries in cancer prevention, early detection, and treatment...
  2. doi Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    Jacques Ferlay
    Section of Cancer Information, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 127:2893-917. 2010
    ..7%) and liver cancer (696,000 deaths, 9.2%). Cancer is neither rare anywhere in the world, nor mainly confined to high-resource countries. Striking differences in the patterns of cancer from region to region are observed...
  3. ncbi Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    D R Matthews
    Diabetologia 28:412-9. 1985
    ....
  4. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  5. doi Prevalence and trends in obesity among US adults, 1999-2008
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4315, Hyattsville, MD 20782, USA
    JAMA 303:235-41. 2010
    ..The prevalence of obesity increased in the United States between 1976-1980 and 1988-1994 and again between 1988-1994 and 1999-2000...
  6. doi Cancer statistics, 2012
    Rebecca Siegel
    Surveillance Research, American Cancer Society, Atlanta, GA 30303 1002, USA
    CA Cancer J Clin 62:10-29. 2012
    ..Further progress can be accelerated by applying existing cancer control knowledge across all segments of the population, with an emphasis on those groups in the lowest socioeconomic bracket...
  7. ncbi Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell 126:663-76. 2006
    ..Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions...
  8. pmc A core gut microbiome in obese and lean twins
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 457:480-4. 2009
    ..Here we characterize the faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers, to address how ..
  9. doi Global estimates of the prevalence of diabetes for 2010 and 2030
    J E Shaw
    Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes Res Clin Pract 87:4-14. 2010
    ..We estimated the number of people worldwide with diabetes for the years 2010 and 2030...
  10. pmc A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009
    ..Equations to estimate glomerular filtration rate (GFR) are routinely used to assess kidney function. Current equations have limited precision and systematically underestimate measured GFR at higher values...
  11. pmc Prevention of HIV-1 infection with early antiretroviral therapy
    Myron S Cohen
    University of North Carolina at Chapel Hill, Institute for Global Health and Infectious Diseases, Suite 2115, Bioinformatics Bldg, 130 Mason Farm Rd, CB 7030, Chapel Hill, NC 27599, USA
    N Engl J Med 365:493-505. 2011
    ..Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples...
  12. ncbi Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    Roger Stupp
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    N Engl J Med 352:987-96. 2005
    ..In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety...
  13. ncbi Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell 131:861-72. 2007
    ..Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc...
  14. doi Prevalence of diabetes among men and women in China
    Wenying Yang
    China Japan Friendship Hospital, Beijing, China
    N Engl J Med 362:1090-101. 2010
    ..Because of the rapid change in lifestyle in China, there is concern that diabetes may become epidemic. We conducted a national study from June 2007 through May 2008 to estimate the prevalence of diabetes among Chinese adults...
  15. pmc Establishing a standard definition for child overweight and obesity worldwide: international survey
    T J Cole
    Department of Epidemiology and Public Health, Institute of Child Health, London WC1N 1EH
    BMJ 320:1240-3. 2000
    ..To develop an internationally acceptable definition of child overweight and obesity, specifying the measurement, the reference population, and the age and sex specific cut off points...
  16. ncbi Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    Thomas J Lynch
    Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    N Engl J Med 350:2129-39. 2004
    ..However, about 10 percent of patients have a rapid and often dramatic clinical response. The molecular mechanisms underlying sensitivity to gefitinib are unknown...
  17. pmc An integrated genomic analysis of human glioblastoma multiforme
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics, and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1807-12. 2008
    ..These studies demonstrate the value of unbiased genomic analyses in the characterization of human brain cancer and identify a potentially useful genetic alteration for the classification and targeted therapy of GBMs...
  18. ncbi Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:593-602. 2005
    ..Little is known about lifetime prevalence or age of onset of DSM-IV disorders...
  19. pmc Inhibition of mutated, activated BRAF in metastatic melanoma
    Keith T Flaherty
    Abramson Cancer Center of the University of Pennsylvania, Philadelphia, USA
    N Engl J Med 363:809-19. 2010
    ..The identification of somatic mutations in the gene encoding the serine-threonine protein kinase B-RAF (BRAF) in the majority of melanomas offers an opportunity to test oncogene-targeted therapy for this disease...
  20. ncbi Global burden of hypertension: analysis of worldwide data
    Patricia M Kearney
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Lancet 365:217-23. 2005
    ..We aimed to pool data from different regions of the world to estimate the overall prevalence and absolute burden of hypertension in 2000, and to estimate the global burden in 2025...
  21. ncbi International physical activity questionnaire: 12-country reliability and validity
    Cora L Craig
    Canadian Fitness and Lifestyle Research Institute, Ottawa, Canada
    Med Sci Sports Exerc 35:1381-95. 2003
    ..The International Physical Activity Questionnaire (IPAQ) was developed as an instrument for cross-national monitoring of physical activity and inactivity...
  22. doi Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
    Supachai Rerks-Ngarm
    Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
    N Engl J Med 361:2209-20. 2009
    ..The development of a safe and effective vaccine against the human immunodeficiency virus type 1 (HIV-1) is critical to pandemic control...
  23. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ....
  24. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  25. ncbi Multilineage potential of adult human mesenchymal stem cells
    M F Pittenger
    Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
    Science 284:143-7. 1999
    Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including ..
  26. ncbi Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    Michael W Fried
    University of North Carolina, Chapel Hill 27599, USA
    N Engl J Med 347:975-82. 2002
    ..We compared the efficacy and safety of peginterferon alfa-2a plus ribavirin, interferon alfa-2b plus ribavirin, and peginterferon alfa-2a alone in the initial treatment of chronic hepatitis C...
  27. ncbi Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data
    Alan D Lopez
    School of Population Health, University of Queensland, Brisbane 4006, Australia
    Lancet 367:1747-57. 2006
    ..Our aim was to calculate the global burden of disease and risk factors for 2001, to examine regional trends from 1990 to 2001, and to provide a starting point for the analysis of the Disease Control Priorities Project (DCPP)...
  28. ncbi Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
    Sarah Lewington
    Lancet 360:1903-13. 2002
    ..The age-specific relevance of blood pressure to cause-specific mortality is best assessed by collaborative meta-analysis of individual participant data from the separate prospective studies...
  29. pmc Projections of global mortality and burden of disease from 2002 to 2030
    Colin D Mathers
    Evidence and Information for Policy Cluster, World Health Organization, Geneva, Switzerland
    PLoS Med 3:e442. 2006
    ..This paper describes the methods, assumptions, input data, and results...
  30. doi Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    Ann Lii Cheng
    National Taiwan University Hospital, Taipei, Taiwan
    Lancet Oncol 10:25-34. 2009
    ....
  31. pmc The PHQ-9: validity of a brief depression severity measure
    K Kroenke
    Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis 46202, USA
    J Gen Intern Med 16:606-13. 2001
    ..While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity...
  32. pmc Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    George Adrian Calin
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:15524-9. 2002
    ..Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority ( approximately 68%) of CLL cases...
  33. pmc Bacterial community variation in human body habitats across space and time
    Elizabeth K Costello
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA
    Science 326:1694-7. 2009
    ..These results indicate that our microbiota, although personalized, varies systematically across body habitats and time; such trends may ultimately reveal how microbiome changes cause or prevent disease...
  34. doi Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4315, Hyattsville, MD 20782, USA
    JAMA 307:491-7. 2012
    Between 1980 and 1999, the prevalence of adult obesity (body mass index [BMI] ≥30) increased in the United States and the distribution of BMI changed. More recent data suggested a slowing or leveling off of these trends.
  35. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
    ..Early detection is essential to reduce the death rate and interrupt transmission, but the complexity and infrastructure needs of sensitive methods limit their accessibility and effect...
  36. ncbi Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation
    K G M M Alberti
    Department of Endocrinology and Metabolic Medicine, St Mary s Hospital, London, UK and International Diabetes Institute, Caulfield, Australia
    Diabet Med 23:469-80. 2006
    ..An additional aim was to highlight areas where more research into the MetS is needed...
  37. pmc Boceprevir for untreated chronic HCV genotype 1 infection
    Fred Poordad
    Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    N Engl J Med 364:1195-206. 2011
    ..The rate of sustained virologic response has been below 50% in cases of HCV genotype 1 infection. Boceprevir, a potent oral HCV-protease inhibitor, has been evaluated as an additional treatment in phase 1 and phase 2 studies...
  38. ncbi Global cancer statistics, 2002
    D Max Parkin
    Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France
    CA Cancer J Clin 55:74-108. 2005
    ..Most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention...
  39. ncbi Short screening scales to monitor population prevalences and trends in non-specific psychological distress
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 32:959-76. 2002
    ..A 10-question screening scale of psychological distress and a six-question short-form scale embedded within the 10-question scale were developed for the redesigned US National Health Interview Survey (NHIS)...
  40. pmc The influence of head motion on intrinsic functional connectivity MRI
    Koene R A van Dijk
    Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
    Neuroimage 59:431-8. 2012
    ..1 mm), and head rotation were estimated in 1000 healthy, young adult subjects each scanned for two resting-state runs on matched 3T scanners...
  41. doi Cancer statistics, 2009
    Ahmedin Jemal
    Cancer Surveillance, Surveillance and Health Policy Research, American Cancer Society, Atlanta, Georgia 30303 1002, USA
    CA Cancer J Clin 59:225-49. 2009
    ..Further progress can be accelerated by applying existing cancer control knowledge across all segments of the population and by supporting new discoveries in cancer prevention, early detection, and treatment...
  42. pmc Common SNPs explain a large proportion of the heritability for human height
    Jian Yang
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 42:565-9. 2010
    ....
  43. pmc Human gut microbiome viewed across age and geography
    Tanya Yatsunenko
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 486:222-7. 2012
    ..Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization...
  44. doi Telaprevir for previously untreated chronic hepatitis C virus infection
    Ira M Jacobson
    Weill Cornell Medical College and Center for the Study of Hepatitis C, New York, NY 10021, USA
    N Engl J Med 364:2405-16. 2011
    ....
  45. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  46. ncbi Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    Earl S Ford
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
    JAMA 287:356-9. 2002
    ..Limited information is available about the prevalence of the metabolic syndrome in the United States, however...
  47. ncbi Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
    ..Another nine features were recorded as present or absent. An anonymized study set of 50 cases (32 from adult hepatology services, 18 from pediatric hepatology services) was assembled, coded, and circulated...
  48. doi Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study
    Karen Barnett
    Quality, Safety and Informatics Research Group, Population Health Sciences Division, University of Dundee, Dundee, UK
    Lancet 380:37-43. 2012
    ..We examined the distribution of multimorbidity, and of comorbidity of physical and mental health disorders, in relation to age and socioeconomic deprivation...
  49. doi Estimates of cancer incidence and mortality in Europe in 2008
    J Ferlay
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Eur J Cancer 46:765-81. 2010
    ..9%). The most common causes of death from cancer were lung cancer (342,000 deaths, 19.9% of the total), colorectal cancer (212,000 deaths, 12.3%), breast cancer (129,000, 7.5%) and stomach cancer (117,000, 6.8%)...
  50. pmc National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants
    Mariel M Finucane
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Lancet 377:557-67. 2011
    ..However, few worldwide comparative analyses of long-term trends of body-mass index (BMI) have been done, and none have used recent national health examination surveys. We estimated worldwide trends in population mean BMI...
  51. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
    ..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
  52. pmc Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    Quarraisha Abdool Karim
    Centre for the AIDS Program of Research in South Africa CAPRISA, Durban 4013, South Africa
    Science 329:1168-74. 2010
    ..Tenofovir gel could potentially fill an important HIV prevention gap, especially for women unable to successfully negotiate mutual monogamy or condom use...
  53. pmc A human gut microbial gene catalogue established by metagenomic sequencing
    Junjie Qin
    BGI Shenzhen, Shenzhen 518083, China
    Nature 464:59-65. 2010
    ..We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions present in all individuals and most bacteria, respectively...
  54. ncbi A gene-expression signature as a predictor of survival in breast cancer
    Marc J van de Vijver
    Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    N Engl J Med 347:1999-2009. 2002
    ..A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy...
  55. pmc Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 101:4637-42. 2004
    ..Finally, a goodness-of-fit analysis applied at the individual subject level suggests that activity in the default-mode network may ultimately prove a sensitive and specific biomarker for incipient AD...
  56. pmc Correspondence of the brain's functional architecture during activation and rest
    Stephen M Smith
    Centre for Functional MRI of the Brain, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:13040-5. 2009
    ..We conclude that the full repertoire of functional networks utilized by the brain in action is continuously and dynamically "active" even when at "rest."..
  57. pmc Diversity of the human intestinal microbial flora
    Paul B Eckburg
    Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Room S 169, 300 Pasteur Drive, Stanford CA 94305 5107, USA
    Science 308:1635-8. 2005
    ..We discovered significant intersubject variability and differences between stool and mucosa community composition. Characterization of this immensely diverse ecosystem is the first step in elucidating its role in health and disease...
  58. ncbi Physical activity in the United States measured by accelerometer
    Richard P Troiano
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Med Sci Sports Exerc 40:181-8. 2008
    ..To describe physical activity levels of children (6-11 yr), adolescents (12-19 yr), and adults (20+ yr), using objective data obtained with accelerometers from a representative sample of the U.S. population...
  59. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    ..To determine the incidence, cost, and outcome of severe sepsis in the United States...
  60. pmc Linking long-term dietary patterns with gut microbial enterotypes
    Gary D Wu
    Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 334:105-8. 2011
    ..Thus, alternative enterotype states are associated with long-term diet...
  61. doi Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    Eric Van Cutsem
    University Hospital Gasthuisberg, Digestive Oncology Unit, Herestraat 49, 3000 Leuven, Belgium
    N Engl J Med 360:1408-17. 2009
    ....
  62. pmc Preexposure chemoprophylaxis for HIV prevention in men who have sex with men
    Robert M Grant
    J David Gladstone Institutes, University of California at San Francisco, 1650 Owens St, San Francisco, CA 94158, USA
    N Engl J Med 363:2587-99. 2010
    ..Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus (HIV) acquisition...
  63. doi Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    Tony S Mok
    State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong
    N Engl J Med 361:947-57. 2009
    ..Previous, uncontrolled studies have suggested that first-line treatment with gefitinib would be efficacious in selected patients with non-small-cell lung cancer...
  64. doi Multiple imputation using chained equations: Issues and guidance for practice
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, U K
    Stat Med 30:377-99. 2011
    ..We stress the limitations of the method and discuss the possible pitfalls. We illustrate the ideas using a data set in mental health, giving Stata code fragments...
  65. ncbi A brief measure for assessing generalized anxiety disorder: the GAD-7
    Robert L Spitzer
    Biometrics Research Department, New York State Psychiatric Institute, New York, NY 10032, USA
    Arch Intern Med 166:1092-7. 2006
    ..The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity...
  66. ncbi Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  67. doi General cardiovascular risk profile for use in primary care: the Framingham Heart Study
    RALPH B D'AGOSTINO
    Boston University, Department of Mathematics and Statistics, 111 Cummington St, Boston, MA 02215, USA
    Circulation 117:743-53. 2008
    ..The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents...
  68. pmc The number of people with glaucoma worldwide in 2010 and 2020
    H A Quigley
    The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Br J Ophthalmol 90:262-7. 2006
    ..To estimate the number of people with open angle (OAG) and angle closure glaucoma (ACG) in 2010 and 2020...
  69. ncbi Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 145:247-54. 2006
    ..The 4-variable equation from the Modification of Diet in Renal Disease (MDRD) Study has been reexpressed for use with a standardized assay...
  70. pmc Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    Eunice L Kwak
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    N Engl J Med 363:1693-703. 2010
    ..We explored the therapeutic efficacy of inhibiting ALK in such tumors in an early-phase clinical trial of crizotinib (PF-02341066), an orally available small-molecule inhibitor of the ALK tyrosine kinase...
  71. doi National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants
    Goodarz Danaei
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Lancet 378:31-40. 2011
    ..We estimated trends and their uncertainties in mean fasting plasma glucose (FPG) and diabetes prevalence for adults aged 25 years and older in 199 countries and territories...
  72. doi Susceptibility to exacerbation in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, United Kingdom
    N Engl J Med 363:1128-38. 2010
    ..In a large observational cohort, we tested the hypothesis that there is a frequent-exacerbation phenotype of COPD that is independent of disease severity...
  73. pmc Antiretroviral prophylaxis for HIV prevention in heterosexual men and women
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    N Engl J Med 367:399-410. 2012
    ..Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations...
  74. doi Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency Centre for Infections, London, UK
    Lancet 375:1100-8. 2010
    ....
  75. pmc Development of a WHO growth reference for school-aged children and adolescents
    Mercedes de Onis
    Department of Nutrition, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 85:660-7. 2007
    ..To construct growth curves for school-aged children and adolescents that accord with the WHO Child Growth Standards for preschool children and the body mass index (BMI) cut-offs for adults...
  76. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
    ..ESS scores of patients who simply snored did not differ from controls...
  77. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
    ..Our findings also provide insight into how this network is modulated by task demands and what functions it might subserve...
  78. pmc Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    Roel G W Verhaak
    The Eli and Edythe L Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Cancer Cell 17:98-110. 2010
    ..We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies...
  79. pmc External review and validation of the Swedish national inpatient register
    Jonas F Ludvigsson
    Department of Paediatrics, Orebro University Hospital, Sweden
    BMC Public Health 11:450. 2011
    ..A previous validation of the IPR by the National Board of Health and Welfare showed that 85-95% of all diagnoses in the IPR are valid. The current paper describes the history, structure, coverage and quality of the Swedish IPR...
  80. ncbi An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
    Rahul S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
    Neuroimage 31:968-80. 2006
    ....
  81. pmc Supervised risk predictor of breast cancer based on intrinsic subtypes
    Joel S Parker
    Lineberger Comprehensive Cancer Center, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Oncol 27:1160-7. 2009
    ..Test sets from 761 patients (no systemic therapy) were evaluated for prognosis, and 133 patients were evaluated for prediction of pathologic complete response (pCR) to a taxane and anthracycline regimen...
  82. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
    ..Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior...
  83. ncbi Prevalence of chronic kidney disease in the United States
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21287, USA
    JAMA 298:2038-47. 2007
    ..Whether there have been changes in the prevalence of earlier stages of chronic kidney disease (CKD) during this period is uncertain...
  84. ncbi Thresholding of statistical maps in functional neuroimaging using the false discovery rate
    Christopher R Genovese
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Neuroimage 15:870-8. 2002
    ..We demonstrate this approach using both simulations and functional magnetic resonance imaging data from two simple experiments...
  85. ncbi Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    Aram V Chobanian
    Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:1206-52. 2003
    ..Positive experiences, trust in the clinician, and empathy improve patient motivation and satisfaction. This report serves as a guide, and the committee continues to recognize that the responsible physician's judgment remains paramount...
  86. doi Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millennium Development Goal 5
    Margaret C Hogan
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA
    Lancet 375:1609-23. 2010
    ..We assessed levels and trends in maternal mortality for 181 countries...
  87. doi The global obesity pandemic: shaped by global drivers and local environments
    Boyd A Swinburn
    WHO Collaborating Centre for Obesity Prevention, Deakin University, Melbourne, Vic, Australia
    Lancet 378:804-14. 2011
    ..This absence increases the urgency for evidence-creating policy action, with a priority on reduction of the supply-side drivers...
  88. ncbi Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    Eugenia E Calle
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta 30329, USA
    N Engl J Med 348:1625-38. 2003
    ..The influence of excess body weight on the risk of death from cancer has not been fully characterized...
  89. pmc Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    Paul B Chapman
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    N Engl J Med 364:2507-16. 2011
    ..Phase 1 and 2 clinical trials of the BRAF kinase inhibitor vemurafenib (PLX4032) have shown response rates of more than 50% in patients with metastatic melanoma with the BRAF V600E mutation...
  90. ncbi An inventory for measuring clinical anxiety: psychometric properties
    A T Beck
    J Consult Clin Psychol 56:893-7. 1988
  91. ncbi Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    Sarah Wild
    Public Health Sciences, University of Edinburgh, Edinburgh, Scotland
    Diabetes Care 27:1047-53. 2004
    ..The goal of this study was to estimate the prevalence of diabetes and the number of people of all ages with diabetes for years 2000 and 2030...
  92. pmc Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:617-27. 2005
    ..Little is known about the general population prevalence or severity of DSM-IV mental disorders...
  93. doi Correlates of physical activity: why are some people physically active and others not?
    Adrian E Bauman
    Prevention Research Collaboration, School of Public Health, Sydney University, NSW, Australia
    Lancet 380:258-71. 2012
    ..An understanding of correlates and determinants, especially in countries of low and middle income, could reduce the eff ect of future epidemics of inactivity and contribute to effective global prevention of non-communicable diseases...
  94. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
    ..Despite this prediction we identify a baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF...
  95. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
    ..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI...
  96. doi Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
    ..Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m2 and serum creatinine was assayed in different laboratories...
  97. doi Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico
    Rogelio Perez-Padilla
    National Institute of Respiratory Diseases, Mexico City, Mexico
    N Engl J Med 361:680-9. 2009
    ....
  98. doi Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus
    Kathy Hancock
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1945-52. 2009
    ....
  99. doi Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
    ..Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America...
  100. pmc The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong
    Joseph T Wu
    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, People s Republic of China
    Clin Infect Dis 51:1184-91. 2010
    ..Serial cross-sectional data on antibody levels to the 2009 pandemic H1N1 influenza A virus from a population can be used to estimate the infection attack rates and immunity against future infection in the community...

Research Grants85

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..We propose to develop anionic, partially lipophilic hyaluronic acid derivatives as a simple mechanistically-based treatment for this chronic extraordinarily common dental disorder. ..
  2. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..will investigate: a) the interaction between home exposure, sensitization, and inflammatory responses among adult patients presenting with acute asthma;b) lung symptoms and asthma among teenage children in rural and city schools,..
  3. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..These studies will point to new ways to treat FSGS and to prevent it from progressing to kidney failure or from recurring in newly transplanted kidneys. ..
  4. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
  5. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..The results may lead to new drugs and interventions to improve eating behavior, and help establish unbiased indicators of obesity risk and prognosis for use in research and clinical settings. ..
  6. Noreen F Rossi; Fiscal Year: 2016
    ....
  7. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..Findings from this study will suggest mechanisms to explain the prior observed associations between sleep duration and CVD risk factors. ..
  8. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..The results of this research may provide a better understanding of ways to prevent and/or treat diabetes and its cardiovascular complications for millions of Americans. ..
  9. BRIAN JAMES MCMAHON; Fiscal Year: 2016
    ..abstract_text> ..
  10. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..Thus the currently proposed studies are significant in terms of clinical implications for limiting cardiac damage in the vulnerable veteran population and for fiscal health of the Department of Veterans Affairs. ..
  11. Roby Greenwald; Fiscal Year: 2016
    ..In addition, we will actively engage in a process of biomarker discovery and evaluation. ..
  12. KEVIN ROBERT VINCENT; Fiscal Year: 2014
    ....
  13. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..The results of this study will aid in the development of evidence-based guidelines for the treatment of Alaska Native infants diagnosed with CPT1A deficiency by newborn screening. ..
  14. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..The existing resources for this secondary data analysis provide an unprecedented cost- efficient opportunity to build on established work and expand knowledge in this important area of public health. ..
  15. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    ..in nutrients during early life `program'increased susceptibility to metabolic disease and hypertension in adult life. However, these studies provide limited insight into the epigenetic mechanisms underlying these processes...
  16. Marcelo B Sztein; Fiscal Year: 2016
    ..Given the shortcomings of available measures to successfully control this infection, and its bioterrorism potential, to develop a S. dysenteriae type 1 vaccine is of great importance. ..
  17. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..abstract_text> ..
  18. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
    ....
  19. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ....
  20. SPEAKER TRAVEL AND SCIENTIFIC SESSION SUPPORT FOR THE TERATOLOGY SOCIETY 50TH
    Christina Chambers; Fiscal Year: 2011
    ..Add Optional Project Narrative File Delete Optional Project Narrative File View Optional Project Narrative File !"#! ..
  21. Laura L Dugan; Fiscal Year: 2014
    ..abstract_text> ..
  22. Melissa A Rosenkranz; Fiscal Year: 2014
    ..abstract_text> ..
  23. Arthur Brody; Fiscal Year: 2016
    ....
  24. Rinn Song; Fiscal Year: 2016
    ....
  25. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..The work proposed here could shed light on molecular mechanisms underlying alcoholism and eventually have implications in the development of novel pharmacological agents for alcoholism or alcohol-related neurological disorders. ..
  26. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ....
  27. Roy Curtiss Iii; Fiscal Year: 2016
    ..We will also develop a RASV using S. Typhi as vector to prevent transmission and infection by Mycobacterium tuberculosis. ..
  28. Mary K Sheats; Fiscal Year: 2016
    ....
  29. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..1 Saper, R.B., Eisenberg, D.M., Davis, R.B., Culpepper, L., Phillips, R.S., 2004. Prevalence and patterns of adult yoga use in the United States: results of a national survey. Altern. Ther. Health Med. 10 (2), 44-49...
  30. INTERNET ENHANCED HEALTH PROMOTION FOR OBESE ETHNIC MINORITY ADOLESCENTS
    Jessica A Whiteley; Fiscal Year: 2011
    ..abstract_text> ..
  31. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..In adult mammals, muscle stem cells (MuSCs) proliferate less, there is less new muscle produced, and there is more fibrosis,..
  32. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..We propose to show its usefulness as a monitor of sleep in health, in those with simple and complicated forms of sleep apnea, and in patients with heart failure. ..
  33. Renée A Shellhaas; Fiscal Year: 2014
    ..abstract_text> ..
  34. JUSTIN RODNEY SAVAGE; Fiscal Year: 2015
    ....
  35. Ken R Smith; Fiscal Year: 2015
    ..Aim 2. Test hypotheses that each adverse ELCs as measured in Aim 1 has enduring adverse effects on adult age-specific all-cause and cause-specific mortality and morbidity risks using data contained within the UPDB ..
  36. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..Marketing approval for TLF to treat NIs would be of great benefit to the patients and the community, and would also be of a substantial commercial value. ..
  37. Robert S Sherwin; Fiscal Year: 2014
    ....
  38. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..disciplines to demonstrate both accomplishment and ability to work together with the following fields represented: Adult Rheumatology, Dermatology, Pulmonary Medicine, and Pediatric Rheumatology...
  39. Edward P Feener; Fiscal Year: 2016
    ..These studies could reveal new therapeutic strategies to treat diabetic macular edema, a leading cause of vision loss. ..
  40. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    ..The results should significantly increase our understanding of the pathophysiology of M-D, which can ultimately aid the development of therapeutic treatments for M-D patients and other dystonia and myoclonus patients. ..
  41. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..The goal is to identify specific markers, like microRNA, or "turned on genes" that may be key to repair the vascular damage and to identify more effective medical interventions. ..
  42. Characterizing TLR Function of Human Dendritic Cells in the Elderly
    Alexander Panda; Fiscal Year: 2012
    ....
  43. PEGGY SUE LAI; Fiscal Year: 2016
    ....
  44. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..This research project will determine if lower ucOC levels predict development of diabetes or increases in total body fat over nine years. ..
  45. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..Finally, depression in women is linked to several major medical illnesses. Thus, a novel intervention for adolescent females with MDD has the potential to broadly impact public health, beyond the boundaries of psychiatry. ..
  46. Barry E Levin; Fiscal Year: 2015
    ..abstract_text> ..
  47. Cell stress, development, and stimulant-induced behavior: Regulation by GSK3
    Marjelo A Mines; Fiscal Year: 2012
    ..to stress, developmental changes in GSK3, and the role of GSK3 in behavioral responses to stimulants in young and adult mice...
  48. Diane R Gold; Fiscal Year: 2014
    ..If vitamin D or marine omega-3 fatty acid supplementation reduce COPD and asthma exacerbations, reduce decline of lung function, improve asthma control and/or reduce pneumonia risk, this would be of great benefit to public health. ..
  49. YEN PEI CHRISTY CHANG; Fiscal Year: 2016
    ..To accomplish these goals, we have brought together investigators who are experts in hypertension genetics, transcriptional regulation, bioinformatics, molecular biology, biochemistry, and renal physiology. ..
  50. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..The goal of our research is to delineate the precise mechanisms of obesity-related cardiovascular disease and thus establish a rationale for therapeutic intervention. ..
  51. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    Douglas H Keefe; Fiscal Year: 2013
    ..battery addresses current limitations in newborn hearing screening (NHS) and diagnostic programs, and may improve adult programs to identify ototoxic hearing loss and diagnose middle-ear disease in patients receiving middle-ear ..
  52. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ....
  53. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..Increased knowledge of the mechanism by which IRP2 regulates iron balance and cell proliferation is important for developing therapeutics that can be used to target cancer cells and treat iron disorders. ..
  54. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ....
  55. Catherine M Gordon; Fiscal Year: 2015
    ..Knowledge gained from this study may also have application to other diseases across the age spectrum that are associated with bone loss and involve alterations in bone marrow composition. ..
  56. Multivariate CART for survival with dental applications
    Martha E Nunn; Fiscal Year: 2013
    ....
  57. Mark D Peterson; Fiscal Year: 2016
    ..Therefore, the overall purpose of this training and research is to examine the adult CP phenotype from the bedside to the bench with the explicit intent to distinguish and target the mechanisms of ..
  58. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..which we developed recently, we will localize the breakpoints in 10 radiation-induced tumors (9 chPTC cases and 1 adult case) for which we have cell lines as well as G-banding and Spectral Karyotyping results...
  59. Interrelationships among nutrients involved in one-carbon metabolism in Banglades
    MEGAN NINA HALL; Fiscal Year: 2011
    ....
  60. SHIKHA SEKSARIA SUNDARAM; Fiscal Year: 2015
    ....
  61. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..Permanent deficits result from these alterations that become more prevalent with age and predispose our increasing elderly population to falls, accidents, and cognitive dysfunctions. ..
  62. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ....
  63. Oral H. pylori Prevalence in Intellectually/Developmentally Disabled Adults
    Catherine Binkley; Fiscal Year: 2009
    ....
  64. Ubiquitous Mobile Multimedia for Environmental Public Health Outreach and Social
    CESAR BANDERA; Fiscal Year: 2010
    ....
  65. NON-INVASIVE HIGH-RESOLUTION DIAGNOSIS OF PERIODONTAL ATTACHMENT LEVELS USING REA
    SAM M MUKDADI; Fiscal Year: 2010
    ..In the State of West Virginia, more than 46.2% of the adults lost all their teeth at the age of 65. A recent oral health study in Appalachia involving 445 families revealed that 85% of the adults had periodontitis. ..
  66. Prevention of Neck Injuries in Older Adults During Rear Motor Vehicle Collsions
    PAUL IVANCIC; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): A neck injury rate of up to 30% has been reported for older adult occupants of rear motor vehicle collisions (RMVCs) and older adults experience longer recovery times, as compared to younger RMVC ..
  67. Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
    Hilary P Blumberg; Fiscal Year: 2010
    ..impact on progress in suicide prevention: identification of neural circuitry biomarkers of adolescent and young adult suicidality and the biological and environmental factors that contribute to their development...
  68. Chicago Endothelial Function Study
    Louise C Hawkley; Fiscal Year: 2010
    ..11/07) Page. Form Page 4 ..
  69. Treatment decision making in older adults newly diagnosed with multiple myeloma
    Joseph D Tariman; Fiscal Year: 2010
    ..Due to the limited studies in older adults with cancer, these specific aspects of decision-making have not been previously explored. ..
  70. The Role of Social Relationships and Self-Efficacy in Diabetes Management
    LINDA WRAY; Fiscal Year: 2009
    ....
  71. DEFINITION AND DEVELOPMENT OF THE PHENOTYPE IN AUTISM
    Sally Rogers; Fiscal Year: 2001
    ....
  72. Sleep Therapy Headset for Improving Sleep Quality of Older Adults
    PHILIP BONELLO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  73. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel A Shugars; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study to assess ..
  74. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    Bennett Tochukwu Amaechi; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study to assess ..
  75. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James D Bader; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study to assess ..
  76. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    Gregg H Gilbert; Fiscal Year: 2010
    ..The Xylitol for Adult Caries Trial (X-ACT) is a three-year, multi-center, randomized, placebo-controlled, double-blind study to assess ..
  77. Risk Factors for Late Life Anxiety
    JOHN CALAMARI; Fiscal Year: 2006
    ..between core affective traits and HD were evaluated in preliminary study 6 in an ethnically diverse, older adult sample...
  78. Cynthia J Brown; Fiscal Year: 2014
    ..The VA medical center system is well suited for this type of research as the population of older patients admitted to the hospital is high and results of future studies can be disseminated nationally through the VA system. ..
  79. Oral Health Status and its Correlates in Adults with Developmental Disabilities
    JOHN PATRICK contact MORGAN; Fiscal Year: 2010
    ....
  80. Treatment Retention Strategies in Transition Age Youth
    Maryann Davis; Fiscal Year: 2010
    ....
  81. Metabolism and Age-Related Organophosphate Toxicity
    Janice Chambers; Fiscal Year: 2005
    ..of vulnerability to toxic effects following exposures to a representative group of OP compounds in juvenile and adult rats, and to characterize the role of detoxication in these vulnerabilities...