simian t lymphotropic virus 1

Summary

Summary: A strain of PRIMATE T-LYMPHOTROPIC VIRUS 2, closely related to the human HTLV-1 virus. The clinical, hematological, and histopathological characteristics of the disease in STLV-infected monkeys are very similar to those of human adult T-cell leukemia. Subgroups include the African green monkey subtype (STLV-I-AGM), for which the nucleotide sequence is 95% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1, and the Asian rhesus macaque subtype (STLV-I-MM), for which the nucleotide sequence is 90% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1.

Top Publications

  1. pmc Isolation and characterization of a new simian T-cell leukemia virus type 1 from naturally infected celebes macaques (Macaca tonkeana): complete nucleotide sequence and phylogenetic relationship with the Australo-Melanesian human T-cell leukemia virus typ
    F Ibrahim
    , Institut Pasteur, France
    J Virol 69:6980-93. 1995
  2. ncbi High simian T-cell leukemia virus type 1 proviral loads combined with genetic stability as a result of cell-associated provirus replication in naturally infected, asymptomatic monkeys
    Anne Sophie Gabet
    Unité d Oncogenèse Virale, Centre Leon Berard, Lyon, France
    Int J Cancer 107:74-83. 2003
  3. ncbi Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology
    A M Vandamme
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium
    J Med Virol 52:1-7. 1997
  4. ncbi Evolutionary inferences of novel simian T lymphotropic virus type 1 from wild-caught chacma (Papio ursinus) and olive baboons (Papio anubis)
    R Mahieux
    , Institut Pasteur, 28 rue du Dr Roux, Paris, Cedex 15, 75724, France
    Virology 251:71-84. 1998
  5. ncbi Seroepidemiologic, molecular, and phylogenetic analyses of simian T-cell leukemia viruses (STLV-I) from various naturally infected monkey species from central and western Africa
    N K Saksena
    Department of Medicine, SUNY Health Science Center, Syracuse 13210
    Virology 198:297-310. 1994
  6. pmc Simian T-cell lymphotropic virus type 1 from Mandrillus sphinx as a simian counterpart of human T-cell lymphotropic virus type 1 subtype D
    R Mahieux
    , Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 72:10316-22. 1998
  7. ncbi Full-genome analysis of a highly divergent simian T-cell lymphotropic virus type 1 strain in Macaca arctoides
    Sonia Van Dooren
    Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Gen Virol 86:1953-9. 2005
  8. ncbi Spontaneously generated non-Hodgkin's lymphoma in twenty-seven simian T-cell leukemia virus type 1 antibody-positive baboons (Papio species)
    G B Hubbard
    Southwest Foundation for Biomedical Research, San Antonio, TX 78228
    Lab Anim Sci 43:301-9. 1993
  9. pmc Phylogenetic associations of human and simian T-cell leukemia/lymphotropic virus type I strains: evidence for interspecies transmission
    I J Koralnik
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892
    J Virol 68:2693-707. 1994
  10. ncbi Two distinct STLV-1 subtypes infecting Mandrillus sphinx follow the geographic distribution of their hosts
    M Makuwa
    Laboratoire de Virologie, UGENET, CDP, SEGC Lopé, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 20:1137-43. 2004

Research Grants

  1. COINFECTION OF MACAQUES WITH STLV-1 AND SIV
    PATRICIA FULTZ; Fiscal Year: 1999
  2. Combination DNA and Attenuated Virus Vaccine for SIV
    Francis Novembre; Fiscal Year: 2002
  3. Genetics of Neuropathogenic SIV Infection
    Francis Novembre; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications106 found, 100 shown here

  1. pmc Isolation and characterization of a new simian T-cell leukemia virus type 1 from naturally infected celebes macaques (Macaca tonkeana): complete nucleotide sequence and phylogenetic relationship with the Australo-Melanesian human T-cell leukemia virus typ
    F Ibrahim
    , Institut Pasteur, France
    J Virol 69:6980-93. 1995
    ....
  2. ncbi High simian T-cell leukemia virus type 1 proviral loads combined with genetic stability as a result of cell-associated provirus replication in naturally infected, asymptomatic monkeys
    Anne Sophie Gabet
    Unité d Oncogenèse Virale, Centre Leon Berard, Lyon, France
    Int J Cancer 107:74-83. 2003
    ....
  3. ncbi Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology
    A M Vandamme
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium
    J Med Virol 52:1-7. 1997
    ..This new assay can identify otherwise undetected HTLV-I or HTLV-II infections and is a useful tool of screening for new types of HTLV among seroindeterminate samples...
  4. ncbi Evolutionary inferences of novel simian T lymphotropic virus type 1 from wild-caught chacma (Papio ursinus) and olive baboons (Papio anubis)
    R Mahieux
    , Institut Pasteur, 28 rue du Dr Roux, Paris, Cedex 15, 75724, France
    Virology 251:71-84. 1998
    ..anubis, corroborates the hypothesis of cross-species transmissions of STLV-1 in the wild. Further, phylogenetic analyses indicate that the known HTLV-1 strains do not share a common origin with nonhuman primates STLV in South Africa...
  5. ncbi Seroepidemiologic, molecular, and phylogenetic analyses of simian T-cell leukemia viruses (STLV-I) from various naturally infected monkey species from central and western Africa
    N K Saksena
    Department of Medicine, SUNY Health Science Center, Syracuse 13210
    Virology 198:297-310. 1994
    ..Comparative amino acid analyses indicated that there was marked conservation of the TAX protein regardless of host species, while the pol and REX proteins exhibited increasing levels of diversity...
  6. pmc Simian T-cell lymphotropic virus type 1 from Mandrillus sphinx as a simian counterpart of human T-cell lymphotropic virus type 1 subtype D
    R Mahieux
    , Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 72:10316-22. 1998
    ..Due to the quasi-identity of both human and monkey viruses, interspecies transmission episodes leading to such a clade may have occurred recently...
  7. ncbi Full-genome analysis of a highly divergent simian T-cell lymphotropic virus type 1 strain in Macaca arctoides
    Sonia Van Dooren
    Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Gen Virol 86:1953-9. 2005
    ..Full-genome molecular-clock analysis supports an archaic introduction of STLV-1 on the Asian continent, at least 269 000-156 000 years ago...
  8. ncbi Spontaneously generated non-Hodgkin's lymphoma in twenty-seven simian T-cell leukemia virus type 1 antibody-positive baboons (Papio species)
    G B Hubbard
    Southwest Foundation for Biomedical Research, San Antonio, TX 78228
    Lab Anim Sci 43:301-9. 1993
    ..The lungs in 14 baboons had thickened pleuras, congestion,edema, and large tan to brown areas of consolidation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  9. pmc Phylogenetic associations of human and simian T-cell leukemia/lymphotropic virus type I strains: evidence for interspecies transmission
    I J Koralnik
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892
    J Virol 68:2693-707. 1994
    ..Geographic concordance of divergent host species that harbor closely related viruses reinforces that physical feasibility for hypothesized interspecies virus transmission in the past and in the present...
  10. ncbi Two distinct STLV-1 subtypes infecting Mandrillus sphinx follow the geographic distribution of their hosts
    M Makuwa
    Laboratoire de Virologie, UGENET, CDP, SEGC Lopé, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 20:1137-43. 2004
    ..The clustering of these new STLV-1mnd sequences with HTLV-1 subtype D and F suggests first, past simian-to-human transmissions in Central Africa and second, that species barriers are easier to cross over than geographic barriers...
  11. pmc Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys (Cercocebus agilis)
    Valerie Courgnaud
    UR36, IRD, and University of Montpellier I, Montpellier, France
    J Virol 78:4700-9. 2004
    ....
  12. ncbi [Epidemiology, origin and genetic diversity of HTLV-1 retrovirus and STLV-1 simian affiliated retrovirus]
    A Gessain
    Departement du SIDA et des Retrovirus, Institut Pasteur, Paris
    Bull Soc Pathol Exot 93:163-71. 2000
    ..g., the slave trade from Africa to the New World...
  13. ncbi Tempo and mode of human and simian T-lymphotropic virus (HTLV/STLV) evolution revealed by analyses of full-genome sequences
    M Salemi
    Rega Institute for Medical Research, KULeuven, Belgium
    Mol Biol Evol 17:374-86. 2000
    ..In particular, the HTLV-I/STLV-I history might suggest a simian migration from Asia to Africa not much earlier than 19,500-60,000 years ago...
  14. ncbi Isolation of sooty mangabey simian T-cell leukemia virus type I [STLV-I(sm)] and characterization of a mangabey T-cell line coinfected with STLV-I(sm) and simian immunodeficiency virus SIVsmmPBj14
    P N Fultz
    Department of Microbiology, University of Alabama School of Medicine, Birmingham, Alabama, 35294, USA
    Virology 235:271-85. 1997
    ..In vitro and in vivo studies of STLV-I(sm) and SIVsmm, both isolated from a naturally infected mangabey monkey, may provide insight into disease induction and manifestations associated with coinfection by their human counterparts...
  15. ncbi Phylogeny of primate T lymphotropic virus type 1 (PTLV-1) including various new Asian and African non-human primate strains
    Sonia Van Dooren
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Infect Genet Evol 7:374-81. 2007
    ..Barbary macaques, not yet described to be STLV-infected, carry a relatively recent acquired, typical African STLV-1, giving us no clue on the phylogeographical origin of PTLV-1...
  16. ncbi Simian T-cell leukemia virus type I infection in captive baboons
    J Mone
    Department of Virology, Southwest Foundation for Biomedical Research, San Antonio, TX 78228
    AIDS Res Hum Retroviruses 8:1653-61. 1992
    ..The detailed study of a large population of naturally infected baboons may therefore shed some light into the complex processes required for the induction of disease associated with HTLV-I infection in humans...
  17. ncbi Two new human T-lymphotropic virus type I phylogenetic subtypes in seroindeterminates, a Mbuti pygmy and a Gabonese, have closest relatives among African STLV-I strains
    M Salemi
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Virology 246:277-87. 1998
    ..In addition, present day serological tests do not reliably type strains within the HTLV-Ib Central African subtype...
  18. ncbi Molecular and phylogenetic analyses of 16 novel simian T cell leukemia virus type 1 from Africa: close relationship of STLV-1 from Allenopithecus nigroviridis to HTLV-1 subtype B strains
    L Meertens
    , , Institut Pasteur, 25 28 Rue du Dr Roux, Paris Cedex 15, 75724, France
    Virology 287:275-85. 2001
    ....
  19. ncbi The discovery of two new divergent STLVs has implications for the evolution and epidemiology of HTLVs
    M van Brussel
    Rega Institute for Medical Research and University Hospitals, Leuven, Belgium
    Rev Med Virol 9:155-70. 1999
    ..Considering the growing interest in xenotransplantations, more epidemiological and biological knowledge of simian and human T-lymphotropic viruses is necessary to estimate the risk of interspecies transmissions...
  20. ncbi Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses
    J P Slattery
    Laboratory of Genomic Diversity, National Cancer Institute Frederick Research Development Center Frederick, Maryland 21702 USA
    Genome Res 9:525-40. 1999
    ..Together, these patterns generate a model of HTLV/STLV emergence marked by an ancient ancestry, differential rates of divergence, and continued global expansion...
  21. ncbi Identification and molecular characterization of new STLV-1 and STLV-3 strains in wild-caught nonhuman primates in Cameroon
    Florian Liegeois
    UMR 145, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, Montpellier, France
    Virology 371:405-17. 2008
    ..cephus. Finally, we identify relative divergence levels in the tax/rex phylogeny suggesting that additional types of PTLV should be defined, particularly for the highly divergent STLV-1(MarB43) strain that we provisionally name STLV-5...
  22. ncbi Transmission dynamics of simian T-lymphotropic virus type 1 (STLV1) in a baboon breeding colony: predominance of female-to-female transmission
    Jean M d'Offay
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, USA
    Comp Med 57:105-14. 2007
    ....
  23. ncbi Simian T cell leukemia virus type I-induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: implication of CD8+ T cell leukemia
    H Akari
    Tsukuba Primate Center, National Institute of Infectious Diseases, Ibaraki, Japan
    AIDS Res Hum Retroviruses 14:367-71. 1998
    ..However, in the case of in vitro-transformed cell lines the expression pattern of the CD8 chains varied in individual monkeys. Thus, STLV-I may preferentially transform CD8+ (both alphaalpha+ and alphabeta+) T cells in AGMs...
  24. ncbi Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa
    K J Song
    Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Virology 199:56-66. 1994
    ..Thus, our data are consistent with an archaic presence of STLV-I in Asia, probably predating macaque speciation, with subsequent independent virus evolution in Asia and Africa...
  25. ncbi Dating the origin of the African human T-cell lymphotropic virus type-i (HTLV-I) subtypes
    S Van Dooren
    Rega Institute for Medical Research, Kotholieke Universiteit Leuven, Leuven, Belgium
    Mol Biol Evol 18:661-71. 2001
    ..Due to the small number of strains in some of the investigated groups, these data on selective pressure should be taken with caution...
  26. ncbi Occurrence and frequency of transmission of naturally occurring simian retroviral infections (SIV, STLV, and SRV) at the CIRMF Primate Center, Gabon
    M C Georges Courbot
    , Franceville, Gabon
    J Med Primatol 25:313-26. 1996
    ..SIV infection was also more frequent in male than female mandrills and sexual transmission appeared to be a rare event. No SRV infection was observed in macaques...
  27. ncbi Non-invasive testing reveals a high prevalence of simian T-lymphotropic virus type 1 antibodies in wild adult chimpanzees of the Taï National Park, Côte d'Ivoire
    Fabian H Leendertz
    Zentrum für Biologische Sicherheit, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Gen Virol 85:3305-12. 2004
    ..The prevalence of STLV-1 antibodies in adults and adolescents was significantly higher (35/49, 71.4 %) than that in infant and juvenile chimpanzees (3/31, 9.7 %)...
  28. ncbi [Prelymphoma as a stage of malignant lymphoma (baboon malignant lymphoma model)]
    L A Iakovleva
    Vopr Onkol 54:338-43. 2008
    ..Clinico-morphological signs of prelymphoma were: hypoplasia, edema and discomplexation in lymph nodes, anemia and inflammatory, i. e. degenerative lesions of the skin and mucous membranes...
  29. ncbi A New STLV-1 in a household pet Cercopithecus nictitans from Gabon
    Maria Makuwa
    Laboratoire de Virologie, UGENET, CDP, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 20:679-83. 2004
    ..These data show that C. nictitans may be the natural carrier of two different molecular types of STLV, one related to STLV-3 and the other possibly one of the simian STLV type 1 counterparts of HTLV-1 subtype D...
  30. ncbi The simian T-lymphotropic virus STLV-PP1664 from Pan paniscus is distinctly related to HTLV-2 but differs in genomic organization
    M van Brussel
    Rega Institute for Medical Research, Louvain, Belgium
    Virology 243:366-79. 1998
    ..Although arguments pro and contra a distinct classification are nearly equally balanced, we propose to classify this virus as an STLV-2, designated STLV-2PP1664...
  31. ncbi Reduced transmission and prevalence of simian T-cell lymphotropic virus in a closed breeding colony of chimpanzees (Pan troglodytes verus)
    H Niphuis
    Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    J Gen Virol 84:615-20. 2003
    ..In contrast, transmission from infected mother to child was not observed, suggesting that this is not a common route of transmission for STLV in this species, which is in contrast to HTLV-1 in humans...
  32. ncbi Characterization of a new simian T-lymphocyte virus type 1 (STLV-1) in a wild living chimpanzee (Pan troglodytes verus) from Ivory Coast: evidence of a new STLV-1 group?
    Fabian H Leendertz
    Retrovirology, Robert Koch Institut, Berlin, Germany
    AIDS Res Hum Retroviruses 19:255-8. 2003
    ..The tax sequences reveal two sequence differences that seem to be unique as they are not found in any of the HTLV-1 or STLV-1 tax sequences from the public databases...
  33. ncbi Specific pathogen-free macaques: definition, history, and current production
    William R Morton
    Paris nhp, PO Box 1454, Edmonds, WA 98020, USA
    ILAR J 49:137-44. 2008
    ..In this review we focus on the nonhuman primates (NHPs) most common to North American NHP research facilities, Asian macaques, and the most common current research application of these animals, modeling of human AIDS...
  34. ncbi Implications of the evolution pattern of human T-cell leukemia retroviruses on their pathogenic virulence (Review)
    Inbal Azran
    Department of Microbiology and Immunology, Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Mol Med 14:909-15. 2004
    ..This change in the mode of the virus spread creates a serious risk for emergence of HTLV-II strains with higher virulence...
  35. ncbi Human T-cell leukemia virus type I isolates from Gabon and Ghana: comparative analysis of proviral genomes
    M Fukasawa
    Department of Animal Pathology, University of Tokyo, Tokyo
    Virology 161:315-20. 1987
    ..These results indicated the existence of some unique strains of HTLV-I transmitted among African people, and the importance of clarifying the origin and transmission of HTLV group viruses...
  36. pmc No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms
    Thomas Burmeister
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
    Retrovirology 4:11. 2007
    ..The primer sequences were based on highly interspecies-conserved virus genome regions. We used this PCR to detect Deltaretroviruses in samples from adult patients with a variety of rare T-cell neoplasms in Germany...
  37. ncbi Immunocytochemical and ultrastructural characterization of human T-lymphotropic virus type I (HTLV-I)-producing rabbit lymphoid cell lines
    Y Ohtsuki
    Department of Pathology, Kochi Medical School, Japan
    Arch Virol 100:245-54. 1988
    ....
  38. ncbi [The virogenic status of cultured continuous simian lymphoid cells and their immunophenotypical characteristics]
    V Z Agrba
    Vopr Virusol 50:44-9. 2005
    ..Whether there is a possible relationship between the type of cells in the culture and the type of their replicating virus(es) is discussed in the paper...
  39. pmc Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation
    J C Mulloy
    Basic Research Laboratory, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    J Virol 72:4408-12. 1998
    ....
  40. ncbi Predictive B- and T-cell linear epitopes in structural proteins of HTLV-I, HTLV-II, and STLV-I
    R B Lal
    Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, GA 30333
    AIDS Res Hum Retroviruses 7:663-70. 1991
    ..These predictive epitopes provide a guide to develop improved diagnostic assays and for the development of potential subunit vaccines for HILV-I and HTLV-II...
  41. pmc One-step, multiplex, real-time PCR assay with molecular beacon probes for simultaneous detection, differentiation, and quantification of human T-cell leukemia virus types 1, 2, and 3
    Guillaume Besson
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    J Clin Microbiol 47:1129-35. 2009
    ..Our new method also could be used for epidemiological studies in Africa and in countries where HTLVs and STLVs are endemic...
  42. pmc Isolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey
    F J Novembre
    Divisions of Microbiology and Immunology, Yerkes Regional Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Virol 72:8841-51. 1998
    ..This virus should provide an excellent system for investigating the mechanism of lentivirus-induced neurologic disease...
  43. pmc Serologic confirmation of simian T-lymphotropic virus type I infection by using immunoassays developed for human T-lymphotropic virus antibody detection
    D L Rudolph
    Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, Georgia 30333
    J Clin Microbiol 30:858-61. 1992
    ....
  44. ncbi Simian T-lymphotropic virus type I infection among wild-caught Indonesian pig-tailed macaques (Macaca nemestrina)
    A L Richards
    Department of Immunology, U S Naval Medical Research Unit No 2, Jakarta, Indonesia
    J Acquir Immune Defic Syndr Hum Retrovirol 19:542-5. 1998
    ..Phylogenic analyses of tax gene fragment sequences from the PCR products of two samples, 930287 and 930306, indicated that these animals were infected with retroviruses related to those of the Asian STLV-I clade...
  45. ncbi The simian origins of the pathogenic human T-cell lymphotropic virus type I
    A M Vandamme
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Trends Microbiol 6:477-83. 1998
    ..Molecular epidemiology suggests that all subtypes arose from separate interspecies transmissions from simians to humans...
  46. ncbi Diversity of STLV-1 strains in wild chimpanzees (Pan troglodytes verus) from Côte d'Ivoire
    Sandra Junglen
    Research Group Emerging Zoonoses, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    Virus Res 150:143-7. 2010
    ..In conclusion, the hypothesis of primate T-lymphotropic virus type 1 (PTLV-1) clustering by geography rather than host should be reconsidered, at least regarding STLV-1 infections in chimpanzees...
  47. ncbi Chronic fatal disease in gorillas seropositive for simian T-lymphotropic virus I antibodies
    J R Blakeslee
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus
    Cancer Lett 37:1-6. 1987
    ..It is not known whether a causal relationship exists between these diseases and STLV-I retrovirus infection...
  48. ncbi The tax gene sequences form two divergent monophyletic lineages corresponding to types I and II of simian and human T-cell leukemia/lymphotropic viruses
    A Giri
    Basic Research Laboratory, National Cancer Institute, Bethesda, Maryland 20892, USA
    Virology 231:96-104. 1997
    ..Evidence of the origin of the type II virus is less clear, but diversity among HTLV-II variants from a single isolated population of Mbati villagers is suggestive but not proof of an African origin...
  49. ncbi Detection of simian T-lymphotropic virus type I using the polymerase chain reaction
    C S Dezzutti
    Department of Veterinary Pathobiology, Ohio State University, Columbus 43210
    Int J Cancer 50:805-10. 1992
    ..Additionally, our data suggest that the tax and pol gene regions are conserved between HTLV-I and STLV-I strains found among these diverse species of non-human primates...
  50. pmc Isolation and characterization of simian T-cell leukemia virus type II from New World monkeys
    Y M Chen
    Institute of Biomedical Sciences, Academia Sinica, Nan Kang, Taipei, Taiwan, Republic of China
    J Virol 68:1149-57. 1994
    ..Spider monkeys infected with STLV-II may serve as an important animal model for HTLV-II infection in humans...
  51. ncbi Subsets of T cells in healthy rhesus macaques (Macaca mulatta) infected with simian T-lymphotropic virus type 1
    Laurie Brignolo
    California National Primate Research Center, University of California, Davis 95616, USA
    Comp Med 54:271-4. 2004
    ..Parameters measured included CD3, CD4, CD8, CD25, CD28, CD38, and HLA-DR cell sets. Significant differences in T-cell subsets or hematologic parameters were not observed between healthy STLV-seropositive and seronegative groups...
  52. ncbi Molecular phylogeny and dissemination of human T-cell lymphotropic virus type I viewed within the context of primate evolution and human migration
    R Yanagihara
    Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Mol Biol (Noisy-le-grand) 41:S145-61. 1995
    ..The immunosuppressive and T-cell activation properties of HTLV-I places at added risk these Australian Aboriginal and Melanesian populations, some of which are in imminent threat of infection with human immunodeficiency virus type 1...
  53. ncbi Constitutive cytokine release by simian T-cell lymphotrophic virus type I (STLV-I) and human T-cell lymphotrophic virus types I/II (HTLV-I/II) transformed cell lines
    A Lazo
    Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus, USA
    J Med Primatol 25:257-66. 1996
    ....
  54. ncbi Simian T cell leukaemia virus type I subtype B in a wild-caught gorilla (Gorilla gorilla gorilla) and chimpanzee (Pan troglodytes vellerosus) from Cameroon
    Eric Nerrienet
    Laboratoire de Virologie, Centre Pasteur du Cameroun, , Cameroon
    J Gen Virol 85:25-9. 2004
    ..Such findings reinforce the hypothesis of interspecies transmission of STLV-I to humans, leading to the present day distribution of HTLV-I in central African inhabitants...
  55. ncbi A novel Epstein-Barr virus-like virus, HV(MNE), in a Macaca nemestrina with mycosis fungoides
    E D Rivadeneira
    National Cancer Institute, Basic Research Laboratory, Bethesda, MD the Leukaemia Research Fund Virus Centre, Department of Veterinary Pathology, University of Glasgow, Glasgow, UK
    Blood 94:2090-101. 1999
    ....
  56. pmc High prevalence of simian T-lymphotropic virus type L in wild ethiopian baboons
    Taichiro Takemura
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Virol 76:1642-8. 2002
    ..Further studies are required to know if STLV-L is spreading into human populations...
  57. ncbi Development of a whole-virus multiplex flow cytometric assay for antibody screening of a specific pathogen-free primate colony
    LaRene Kuller
    Washington National Primate Research Center, University of Washington, Box 357331, Seattle, 98195, USA
    Diagn Microbiol Infect Dis 53:185-93. 2005
    ..The multiplexed assay provided greater sensitivity, increased stability, and better performance than ELISA...
  58. ncbi Lymphoproliferative disorders developing after transplantation and their relation to simian T-cell leukemia virus infection
    H P Stevens
    Department of Plastic and Reconstructive Surgery, University Hospital Dijkzigt, Rotterdam, The Netherlands
    Transpl Int 5:S450-3. 1992
    ..In conclusion, for the first time the oncogenic potential of STLV is identified in a rhesus monkey transplantation model. Moreover, the importance of screening blood and organ donors for HTLV-1 must be emphasized...
  59. ncbi Transmission of STLV in a closed colony of macaques
    Stephanie W K Parrish
    U S Military HIV Research Program, Henry M Jackson Foundation, Rockville, Maryland, USA
    Am J Primatol 63:103-9. 2004
    ..Transmission by all routes was infrequent, as indicated by the overall seroprevalence of 3.3% (14 of 420 samples) after the colony had been closed for 11 years. Maternal-infant transmission appeared to be < 12%...
  60. ncbi Prevalence of antibodies against simian immunodeficiency virus (SIV) and simian T-lymphotropic virus (STLV) in a colony of non-human primates in Kenya, East Africa
    M Otsyula
    Institute of Primate Research, Nairobi, Kenya
    Ann Trop Med Parasitol 90:65-70. 1996
    ..However, the relatively high prevalence of anti-SIV and anti-STLV antibodies in these monkeys offers an opportunity for prospective studies on the transmission and natural history of both viruses in a single colony...
  61. ncbi The three human T-lymphotropic virus type I subtypes arose from three geographically distinct simian reservoirs
    H F Liu
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Gen Virol 77:359-68. 1996
    ..In the rooted env trees obtained using the STLV strain PH969 as an outgroup, the Asian strains branched off before the African strains, implying an Asian origin for HTLV/STLV type I based on presently available strains...
  62. ncbi Multiple interspecies transmissions of human and simian T-cell leukemia/lymphoma virus type I sequences
    K A Crandall
    Department of Zoology, University of Texas at Austin 78712 1064, USA
    Mol Biol Evol 13:115-31. 1996
    ..Finally, this approach is compared directly to results obtained from a traditional maximum parsimony approach and found to be superior at establishing relationships and identifying instances of transmission...
  63. ncbi Simian T-cell lymphotropic virus type I alters the proviral load and biodistribution of simian retrovirus type 2 in co-infected macaques, supporting advancement of immunosuppressive pathology
    Jane L Mitchell
    Divisions of Virology, National Institute for Biological Standards and Control, A Centre of the Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, UK
    J Gen Virol 94:623-33. 2013
    ....
  64. ncbi New insights in HTLV-I phylogeny by sequencing and analyzing the entire envelope gene
    Sophie Capdepont
    Laboratoire de Virologie EA2968, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    AIDS Res Hum Retroviruses 21:28-42. 2005
    ..In addition, we showed that within each PTLV-I subtype, groups of isolates may be characterized by nonrandom and systematically associated mutations...
  65. ncbi Serological and nucleic acid analyses for HIV and HTLV infection on archival human plasma samples from Zaire
    D K Dube
    Department of Medicine, State University of New York Health Science Center, Syracuse 13210
    Virology 202:379-89. 1994
    ..The Zairean HTLV-II isolate is closely grouped with the HTLV-II substrain of isolates found in Paleo-Amerindians of the New World, making it unlikely that it represents an endemic African strain...
  66. pmc Isolation of a novel simian T-cell lymphotropic virus from Pan paniscus that is distantly related to the human T-cell leukemia/lymphotropic virus types I and II
    A Giri
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892
    J Virol 68:8392-5. 1994
    ....
  67. ncbi Phylogenesis and genetic complexity of the nonhuman primate retroviridae
    G Franchini
    Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    AIDS Res Hum Retroviruses 10:1047-60. 1994
    ..In this article we attempt to parallel the genetic features of the simian retroviridae with their human counterparts and argue for the possibility of horizontal transmission of these viruses from monkeys to humans...
  68. ncbi Sequence analysis of an immunogenic and neutralizing domain of the human T-cell lymphoma/leukemia virus type I gp46 surface membrane protein among various primate T-cell lymphoma/leukemia virus isolates including those from a patient with both HTLV-I-asso
    M P Sherman
    Department of Medicine and Microbiology Immunology, State University of New York, Syracuse 13210
    Cancer Res 53:6067-73. 1993
    ..No consistent disease-related changes were observed.(ABSTRACT TRUNCATED AT 400 WORDS)..
  69. ncbi Human T-cell leukaemia virus
    G Franchini
    Animal Model and Vaccine Section, National Cancer Institute, Bethesda, MD 20892, USA
    Baillieres Clin Haematol 8:131-48. 1995
    ..Episodes of horizontal transmission in the past and probably the present, indicates that nonhuman primates are the natural reservoir of HTLVs. New related viruses will likely be discovered in monkeys (and humans) in the future...
  70. ncbi Species-dependent antigenicity of the 34-kDa glycoprotein found on the membrane of various primate lymphocytes transformed by human T-cell leukemia virus type-I (HTLV-I) and simian T-cell leukemia virus (STLV-I)
    H Tozawa
    Department of Immunology, School of Hygienic Sciences, Kitasato University, Kanagawa, Japan
    Int J Cancer 41:231-8. 1988
    ..2 at 37 degrees C, TA34 antigen lost its reactivity with TAG34, suggesting that the antigen has an intramolecular S-S bond. Twenty sera of adult T-cell leukemia (ATL) patients did not react with TA34 antigen in RIP tests...
  71. pmc The simian T-lymphotropic/leukemia virus from Pan paniscus belongs to the type 2 family and infects Asian macaques
    L Digilio
    Laboratory of Basic Research, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    J Virol 71:3684-92. 1997
    ..In summary, STLV-2(pan-p) is a novel retrovirus distantly related to HTLV-2 and displays a host range similar to that demonstrated for other HTLV and STLV strains...
  72. ncbi Prevalence of natural infection with simian immunodeficiency virus and simian T-cell leukemia virus type I in a breeding colony of sooty mangabey monkeys
    P N Fultz
    Yerkes Regional Primate Research Center, Atlanta, Georgia 30322
    AIDS 4:619-25. 1990
    ....
  73. pmc High prevalence, coinfection rate, and genetic diversity of retroviruses in wild red colobus monkeys (Piliocolobus badius badius) in Tai National Park, Cote d'Ivoire
    Siv Aina J Leendertz
    Research Group Emerging Zoonoses, Robert Koch Institut, Nordufer 20, Berlin, Germany
    J Virol 84:7427-36. 2010
    ..The high prevalence of all three retroviral infections in P. b. badius represents a source of infection to chimpanzees and possibly to humans, who hunt them...
  74. ncbi Development of a monoclonal antibody-based p24 capsid antigen detection assay for HTLV-I, HTLV-II, and STLV-I infection
    G Toedter
    Coulter Immunology, Hialeah, Florida
    AIDS Res Hum Retroviruses 8:527-32. 1992
    ..Similarly, normal human peripheral blood mononuclear cells and uninfected, transformed human T cells, were also negative in the assay.(ABSTRACT TRUNCATED AT 250 WORDS)..
  75. pmc Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2
    Toshiyuki Shoji
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 6:83. 2009
    ..This distinction was mediated by at least two Tax1 specific functions, an interaction with host cellular factors through the PDZ domain binding motif (PBM) and the activation of NF-kappa B2 (NF-kappa B2)/p100...
  76. ncbi T-cell tropism of simian T-cell leukaemia virus type 1 and cytokine profiles in relation to proviral load and immunological changes during chronic infection of naturally infected mandrills (Mandrillus sphinx)
    Sandrine Souquiere
    Département de Rétrovirologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    J Med Primatol 38:279-89. 2009
    ..Although a wide variety of non-human primates are susceptible to simian T-cell leukaemia virus type 1 (STLV-1), little is known about the virological or molecular determinants of natural STLV-1 infection...
  77. ncbi Production of a recombinant human T-cell leukemia virus type-I trans-activator (tax1) antigen and its utilization for generation of monoclonal antibodies against various epitopes on the tax1 antigen
    Y Tanaka
    Department of Immunology, School of Hygienic Sciences, Kitasato University, Japan
    Int J Cancer 48:623-30. 1991
    ..Sera from HTLV-I-infected humans interfered with the binding of all of these anti-tax1 MAbs. These results indicate that the tax1 antigen and the PX141 express at least 5 distinct epitopes recognized by human and mouse antibodies...
  78. ncbi Differential distribution of antibodies to different viruses in young animals in the free-ranging rhesus macaques of Cayo Santiago
    C A Sariol
    Caribbean Primate Research Center, Unit of Comparative Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA
    J Med Primatol 35:369-75. 2006
    ..The seroprevalence to cercopithecine herpesvirus type 1 (B virus) and simian retroviruses has been studied previously...
  79. ncbi Simian T cell leukemia virus type-1-specific killer T cells in naturally infected African green monkey carriers
    N Yoshimura
    Department of Animal Pathology, University of Tokyo, Japan
    J Immunol 144:2173-8. 1990
    ..In addition NK cell activity in PBL of infected monkeys were significantly higher than those in the uninfected...
  80. ncbi Ancient DNA identification of early 20th century simian T-cell leukemia virus type 1
    Sebastien Calvignac
    Universite de Lyon, Paléogénétique et Evolution Moléculaire, Institut de Genomique Fonctionnelle, INRA, CNRS, UCB Lyon I, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Biol Evol 25:1093-8. 2008
    ..This represents the first clear evidence that it will be possible to use museum specimens to better characterize simian and human T-tropic retrovirus genetic diversity and analyze their origin and evolution, in greater detail...
  81. ncbi Subunit vaccine protects Macaca nemestrina (pig-tailed macaque) against simian T-cell lymphotropic virus type I challenge
    C S Dezzutti
    Center for Retrovirus Research, Columbus, Ohio 43210
    Cancer Res 50:5687S-5691S. 1990
    ..The data presented here demonstrate that the vaccine was successful in protecting Macaca nemestrina from simian T-cell lymphotropic virus type I infection...
  82. ncbi Radiation-induced glioblastoma multiforme in two adult baboons (Papio cynocephalus anubis)
    Jo Ellen Schielke
    Washington National Primate Research Center, University of Washington, Seattle, Washington, USA
    Comp Med 54:327-32. 2004
    ..A definitive diagnosis was made in these cases, using histopathologic criteria of cellular pleomorphism, high mitotic rate, regions of coagulation necrosis, and endothelial proliferation...
  83. ncbi Morphological characteristics of malignant T-cell lymphomas in baboons
    L A Yakovleva
    Institute of Experimental Pathology and Therapy, Sukhumi, Abkhazia, Georgia
    Virchows Arch A Pathol Anat Histopathol 422:109-20. 1993
    ..Despite this virological resemblance, the morphology of these T-cell lymphomas does not resemble that of the HTLV-1-positive Japanese T-cell lymphomas but is like that of the HTLV-1-negative European cases...
  84. ncbi Molecular characterization and phylogenetic analyses of a new simian T cell lymphotropic virus type 1 in a wild-caught african baboon (Papio anubis) with an indeterminate STLV type 2-like serology
    R Mahieux
    Unité d Oncologie Virale, Institut Pasteur, 75724 Paris Cedex 15, France
    AIDS Res Hum Retroviruses 16:2043-8. 2000
    ..The complete p19 sequence reveals amino acid changes at critical positions. This is the first report of an African STLV-1 virus leading to an STLV-2-like serological profile in its host...
  85. ncbi Simian T-lymphotropic virus type 1 (STLV-1) infection in wild yellow baboons (Papio hamadryas cynocephalus) from Mikumi National Park, Tanzania
    A Voevodin
    Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait
    Virology 228:350-9. 1997
    ....
  86. ncbi [HTLV-1 infection in time and space]
    M C Georges-Courbot
    Centre International de Recherche Medicale de Franceville, Gabon
    Med Trop (Mars) 59:469-74. 1999
    ..Diagnosis is now easy and can reduce transmission by intravenous drugs use. Development of a vaccine seems possible given the low genetic variability of this virus...
  87. pmc Molecular characterization and phylogenetic analyses of a new, highly divergent simian T-cell lymphotropic virus type 1 (STLV-1marc1) in Macaca arctoides
    R Mahieux
    , Institut Pasteur, Paris, France
    J Virol 71:6253-8. 1997
    ....
  88. ncbi Isolation of STLV-I from orangutan, a great ape species in Southeast Asia, and its relation to other HTLV-Is/STLV-Is
    K Ibuki
    Laboratory of Pathogenic Virus, Institute for Virus Research, Kyoto University, Sakyo ku
    Jpn J Cancer Res 88:1-4. 1997
    ..A phylogenetic analysis indicated that orangutan STLV-I is related to the Melanesian group of HTLV-Is and other Asian STLV-Is, but the degree of divergence is considerable...
  89. ncbi Association of primate T-cell lymphotropic virus infection of pig-tailed macaques with high mortality
    Therese M McGinn
    Department of Microbiology, University of Alabama School of Medicine, Brimingham 35294, USA
    Virology 304:364-78. 2002
    ..This unexpected high mortality within a relatively short time suggests that infection of pig-tailed macaques might be a useful model for studying immune responses to and pathologic events resulting from HTLV-I infection...
  90. pmc Initiation of translation by non-AUG codons in human T-cell lymphotropic virus type I mRNA encoding both Rex and Tax regulatory proteins
    S Corcelette
    , INSERM U 369, , 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Nucleic Acids Res 28:1625-34. 2000
    ....
  91. ncbi The natural history and evolution of human and simian T cell leukemia/lymphotropic viruses
    G A Dekaban
    John P Robarts Research Institute, London, Ontario, Canada
    Curr Opin Genet Dev 5:807-13. 1995
    ....
  92. ncbi Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in Brazil
    Marcia Ribeiro Andrade
    Oswaldo Cruz Foundation, Centro de Criação de Animais de Loboratório, Rio de Janeiro, Brazil
    Am J Primatol 59:123-8. 2003
    ..All samples were negative for antibodies against the simian retroviruses. The overall prevalence of antibodies was 95% for RhCMV, 45% for B virus, 35% for HAV, and 1% for MV. Prevalence was found to vary by age group...
  93. ncbi Sequence variation and subtyping of human and simian T-cell lymphotropic virus type I strains from South Africa
    S Englebrecht
    Department of Medical Virology, University of Stellenbosch and Tygerberg Hospital, Tygerberg, South Africa
    J Acquir Immune Defic Syndr Hum Retrovirol 12:298-302. 1996
    ..3 to 7%. The STLV-I strains were closely related to that of a chimpanzee, providing evidence of interspecies transmission...
  94. ncbi Different models, different trees: the geographic origin of PTLV-I
    C R Kelsey
    Department of Zoology, Brigham Young University, Provo, Utah 84602 5255, USA
    Mol Phylogenet Evol 13:336-47. 1999
    ..Our best estimates of phylogenetic relationships, however, support an African origin of PTLV for each gene region...
  95. pmc High variety of different simian T-cell leukemia virus type 1 strains in chimpanzees (Pan troglodytes verus) of the Taï National Park, Côte d'Ivoire
    Fabian H Leendertz
    Division of Retrovirology, Robert Koch Institute, D 13353 Berlin, Germany
    J Virol 78:4352-6. 2004
    ....
  96. ncbi Identification of novel singly spliced pX mRNA transcripts common to all human T-cell leukemia virus type 1-related retroviruses
    S Orita
    Shionogi Institute for Medical Science, Osaka, Japan
    Virus Genes 7:197-204. 1993
    ..This novel mRNA in the HTLV-1-related virus group may be analogous to the two-exon nef specific mRNA in human immunodeficiency virus type 1...
  97. ncbi Antibody responses to the env epitopes of human T-lymphotropic virus type I in rhesus macaques' naturally infected with simian T-lymphotropic virus type I
    D L Rudolph
    Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, GA 30333
    Res Virol 144:193-9. 1993
    ....
  98. ncbi The prevalence of antibodies to simian T-cell leukaemia/lymphotropic virus (STLV-I) in non-human primate colonies in Kenya
    J M Mwenda
    Institute of Primate Research, Karen, Nairobi, Kenya
    Ann Trop Med Parasitol 93:289-97. 1999
    ..The relatively high prevalence of anti-STLV-I antibodies in these non-human primates offers an opportunity for studies on the transmission, phylogenetic relationships and natural history of STLV-I in primate colonies...
  99. ncbi [Morpho-immunologic phenotypes of T-cell non-Hodgkin's malignant lymphoma in baboons and their connection with with T-lymphotropic retrovirus STLV-1]
    L A Iakovleva
    Max von Pettenkofer Institute, Munchen, Germany
    Arkh Patol 59:19-25. 1997
    ..CD4+ immune phenotypes were predominant in T-cell baboon lymphomas, while CD8+ phenotypes were rare. Abnormal phenotypes in some cases were also detected in the three-color FACS-analyses...
  100. ncbi Efficacy of an HTLV-1 subunit vaccine in prevention of a STLV-1 infection in pig-tailed macaques
    C S Dezzutti
    Ohio State University, Department of Veterinary Pathobiology, Columbus 43210
    Dev Biol Stand 72:287-96. 1990
    ..RT activity was exclusively present in the non-immunized, control monkeys implying that the HTLV-1 subunit vaccine was successful in protecting the pig-tailed macaques from the STLV-1 infection...
  101. ncbi Sequence and phylogenetic analyses of a new STLV-I from a naturally infected tantalus monkey from Central Africa
    N K Saksena
    Department of Medicine and Microbiology, SUNY Health Science Center, Syracuse, New York 13210
    Virology 192:312-20. 1993
    ..The data also indicate that interspecies transmission occurred several times on different continents over prolonged periods of time...

Research Grants3

  1. COINFECTION OF MACAQUES WITH STLV-1 AND SIV
    PATRICIA FULTZ; Fiscal Year: 1999
    ....
  2. Combination DNA and Attenuated Virus Vaccine for SIV
    Francis Novembre; Fiscal Year: 2002
    ..Additionally, these studies will allow a comparison to other DNA-based strategies currently being utilized at the Yerkes Center. ..
  3. Genetics of Neuropathogenic SIV Infection
    Francis Novembre; Fiscal Year: 2007
    ..Finally, we will investigate the evolution of the ability of these viruses to induce the production of neurotoxins in CNS derived cells. ..