murine leukemia virus

Summary

Summary: Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.

Top Publications

  1. pmc Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions
    Timothy J Henrich
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Infect Dis 202:1478-81. 2010
  2. pmc Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions
    Bryan P Danielson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 202:1470-7. 2010
  3. pmc Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides
    Robin Chan
    Centre for Life Sciences CeLS, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Level 04 21, Singapore 117607, Singapore
    J Virol 82:11228-38. 2008
  4. ncbi Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections
    Eleanor Barnes
    Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom
    J Infect Dis 202:1482-5. 2010
  5. ncbi DNA deamination mediates innate immunity to retroviral infection
    Reuben S Harris
    Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, United Kingdom
    Cell 113:803-9. 2003
  6. ncbi Visualization of retroviral replication in living cells reveals budding into multivesicular bodies
    Nathan M Sherer
    Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536, USA
    Traffic 4:785-801. 2003
  7. ncbi Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV
    Kevin J Kunstman
    Northwestern University, Chicago, Illinois 60611, USA
    AIDS 24:1784-5. 2010
  8. ncbi Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer
    Judy A Mikovits
    Whittemore Peterson Institute for Neuroimmune Diseases, University of Nevada, Reno, NV 89557, USA
    AIDS Rev 12:149-52. 2010
  9. pmc Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity
    Zuzana Keckesova
    Department of Infection, Royal Free and University College Medical School, University College London, Windeyer Building, 46 Cleveland Street, London W1T4JF, United Kingdom
    J Virol 80:4683-90. 2006
  10. pmc Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors
    Harriet C T Groom
    Division of Virology, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 107:5166-71. 2010

Detail Information

Publications240 found, 100 shown here

  1. pmc Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions
    Timothy J Henrich
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Infect Dis 202:1478-81. 2010
    We investigated the prevalence of xenotropic murine leukemia virus-related virus (XMRV) among 293 participants seen at academic hospitals in Boston, Massachusetts...
  2. pmc Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions
    Bryan P Danielson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 202:1470-7. 2010
    There are questions regarding the prevalence of xenotropic murine leukemia virus-related virus (XMRV) in patients with prostate cancer and its association with the RNASEL R462Q polymorphism...
  3. pmc Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides
    Robin Chan
    Centre for Life Sciences CeLS, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Level 04 21, Singapore 117607, Singapore
    J Virol 82:11228-38. 2008
    ..present mass spectrometry analysis of the lipid content of human immunodeficiency virus type 1 (HIV-1) and murine leukemia virus (MLV)...
  4. ncbi Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections
    Eleanor Barnes
    Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom
    J Infect Dis 202:1482-5. 2010
    A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population...
  5. ncbi DNA deamination mediates innate immunity to retroviral infection
    Reuben S Harris
    Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, United Kingdom
    Cell 113:803-9. 2003
    ..Here, using a murine leukemia virus (MLV)-based system, we provide evidence that CEM15/APOBEC3G is a DNA deaminase that is incorporated into ..
  6. ncbi Visualization of retroviral replication in living cells reveals budding into multivesicular bodies
    Nathan M Sherer
    Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536, USA
    Traffic 4:785-801. 2003
    ..However, here we demonstrate that HIV Gag and murine leukemia virus (MLV) Gag also drive assembly intracellularly in cell types including 293 and HeLa cells, previously ..
  7. ncbi Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV
    Kevin J Kunstman
    Northwestern University, Chicago, Illinois 60611, USA
    AIDS 24:1784-5. 2010
    Xenotropic murine leukemia virus-related virus has been detected in blood cells of patients with chronic fatigue syndrome and in 3.7% of healthy controls from the same geographic region...
  8. ncbi Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer
    Judy A Mikovits
    Whittemore Peterson Institute for Neuroimmune Diseases, University of Nevada, Reno, NV 89557, USA
    AIDS Rev 12:149-52. 2010
    In 2006, sequences described as xenotropic murine leukemia virus-related virus (XMRV) were discovered in prostate cancer patients...
  9. pmc Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity
    Zuzana Keckesova
    Department of Infection, Royal Free and University College Medical School, University College London, Windeyer Building, 46 Cleveland Street, London W1T4JF, United Kingdom
    J Virol 80:4683-90. 2006
    ..We speculate that cyclophilin A alters HIV-1 sensitivity to a TRIM5alpha-independent innate immune pathway in human cells...
  10. pmc Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors
    Harriet C T Groom
    Division of Virology, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 107:5166-71. 2010
    Xenotropic murine leukemia virus-related virus (XMRV) is a recently discovered gammaretrovirus that has been linked to prostate cancer and chronic fatigue syndrome...
  11. ncbi Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region
    H T Cuypers
    Cell 37:141-50. 1984
    ..The activated region does not show any homology with 13 known and three putative oncogenes...
  12. pmc The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3
    Marc Andre Langlois
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom CB2 0QH
    J Virol 83:11550-9. 2009
    ....
  13. pmc Sequence analysis of amphotropic and 10A1 murine leukemia viruses: close relationship to mink cell focus-inducing viruses
    D Ott
    Laboratory of Molecular Virology and Carcinogenesis, NCI Frederick Cancer Research Facility, Maryland 21701
    J Virol 64:757-66. 1990
    Viral interference studies have demonstrated the existence of four distinct murine leukemia virus (MuLV) receptors on NIH 3T3 mouse cells...
  14. pmc Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferon-sensitive virus release through lipid rafts
    Takayuki Nitta
    Department of Molecular Biology and Biochemistry, and Cancer Research Institute, University of California, Irvine, CA 92697 3905, USA
    Proc Natl Acad Sci U S A 107:1190-5. 2010
    ..Here, it is shown that gPr80gag facilitates release of Moloney murine leukemia virus (M-MuLV) from cells along an IFN-sensitive pathway...
  15. pmc Androgen stimulates transcription and replication of xenotropic murine leukemia virus-related virus
    Beihua Dong
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Virol 84:1648-51. 2010
    Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus originally identified in a subset of prostate cancer patients...
  16. pmc Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer
    Sanggu Kim
    Biomedical Engineering Interdepartmental Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 82:9964-77. 2008
    Xenotropic murine leukemia virus-related virus (XMRV) is a new human gammaretrovirus identified in prostate cancer tissue from patients homozygous for a reduced-activity variant of the antiviral enzyme RNase L...
  17. pmc Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells
    Sushma Bhosle
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Virol 84:6288-96. 2010
    The newly identified retrovirus-the xenotropic murine leukemia virus-related virus (XMRV)-has recently been shown to be strongly associated with familial prostate cancer in humans (A. Urisman et al., PLoS Pathog. 2:e25, 2006)...
  18. ncbi Cytidine deamination of retroviral DNA by diverse APOBEC proteins
    Kate N Bishop
    Department of Infectious Diseases, Guy s, King s and St Thomas School of Medicine, King s College London, London, SE1 9RT, United Kingdom
    Curr Biol 14:1392-6. 2004
    The human cytidine deaminase APOBEC3G edits both nascent human immunodeficiency virus (HIV) and murine leukemia virus (MLV) reverse transcripts, resulting in loss of infectivity...
  19. pmc Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs
    Tobias Paprotka
    Viral Mutation Section, National Cancer Institute Frederick, P O Box B, Frederick, MD 21702 1201, USA
    J Virol 84:5719-29. 2010
    Xenotropic murine leukemia virus-related virus (XMRV), a gammaretrovirus, has been isolated from human prostate cancer tissue and from activated CD4(+) T cells and B cells of patients with chronic fatigue syndrome, suggesting an ..
  20. pmc TRIM28 mediates primer binding site-targeted silencing of Lys1,2 tRNA-utilizing retroviruses in embryonic cells
    Daniel Wolf
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:12521-6. 2008
    ..These results generalize the role of TRIM28 in retroviral restriction and suggest that this system has evolved to restrict multiple retroviruses...
  21. ncbi Molecular cloning, complete sequence, and biological characterization of a xenotropic murine leukemia virus constitutively released from the human B-lymphoblastoid cell line DG-75
    Kevin P Raisch
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Virology 308:83-91. 2003
    ..Viral interference and infectivity assays confirmed the xenotropic nature of the DG-75 retrovirus. The DG-75 retrovirus is the first isolate of an exogenous xenotropic MLV in which the full-length genomic sequence has been characterized...
  22. pmc Activation of membrane fusion by murine leukemia viruses is controlled in cis or in trans by interactions between the receptor-binding domain and a conserved disulfide loop of the carboxy terminus of the surface glycoprotein
    D Lavillette
    , INSERM U412, , Lyon, France
    J Virol 75:3685-95. 2001
    ..domain (RBD) and the major disulfide loop of the carboxy-terminal domain (C domain) of the murine leukemia virus SU...
  23. pmc Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract
    Nicole Fischer
    Institute for Medical Microbiology and Virology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Emerg Infect Dis 16:1000-2. 2010
    Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using PCR...
  24. pmc Evidence that ecotropic murine leukemia virus contamination in TZM-bl cells does not affect the outcome of neutralizing antibody assays with human immunodeficiency virus type 1
    Emily J Platt
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, 97201, USA
    J Virol 83:8289-92. 2009
    ..human immunodeficiency virus type 1 (HIV-1) was recently reported to be contaminated with an ecotropic murine leukemia virus (MLV) (Y. Takeuchi, M. O. McClure, and M. Pizzato, J. Virol...
  25. pmc A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus
    Felipe Diaz-Griffero
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Virology 378:233-42. 2008
    Human TRIM5alpha restricts N-tropic murine leukemia virus (N-MLV) but not B-tropic MLV (B-MLV) infection. Here we study B30...
  26. ncbi Structural criteria for regulation of membrane fusion and virion incorporation by the murine leukemia virus TM cytoplasmic domain
    Gwen M Taylor
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
    Virology 312:295-305. 2003
    ..Our quantitative analysis of the effects of Moloney murine leukemia virus TM mutations on envelope-protein function support the proposition that a trimeric coiled coil in the TM ..
  27. ncbi Transcription start regions in the human genome are favored targets for MLV integration
    Xiaolin Wu
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 8004, USA
    Science 300:1749-51. 2003
    ..In this study, 903 murine leukemia virus (MLV) and 379 human immunodeficiency virus-1 (HIV-1) integrations in the human genome were mapped...
  28. pmc Role of murine leukemia virus nucleocapsid protein in virus assembly
    Delphine Muriaux
    HIV Drug Resistance Program, National Cancer Institute Frederick, P O Box B, Frederick, MD 21702 1201, USA
    J Virol 78:12378-85. 2004
    ..In this work, we explore the role of NC in murine leukemia virus (MLV) particle assembly and release...
  29. pmc Two surface-exposed elements of the B30.2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5alpha
    Michel J Perron
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA
    J Virol 80:5631-6. 2006
    Human TRIM5alpha (TRIM5alpha(hu)) potently restricts N-tropic (N-MLV), but not B-tropic, murine leukemia virus in a manner dependent upon residue 110 of the viral capsid...
  30. pmc Two distinct mechanisms regulate recruitment of murine leukemia virus envelope protein to retroviral assembly sites
    Tiffany M Lucas
    Department of Molecular Microbiology and Immunology, Christopher S Bond Life Science Center, University of Missouri School of Medicine, Columbia, MO 65211, USA
    Virology 405:548-55. 2010
    ..We generated a panel of murine leukemia virus (MLV) Env mutants and analyzed their ability to be recruited to human immunodeficiency virus-1 (HIV-1) ..
  31. pmc Murine leukemia virus nucleocapsid mutant particles lacking viral RNA encapsidate ribosomes
    Delphine Muriaux
    HIV Drug Resistance Program, and Image Analysis Laboratory SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    J Virol 76:11405-13. 2002
    ..We previously showed that mutant murine leukemia virus (MuLV) particles that lack viral RNA because of a deletion in the cis-acting packaging signal ("Psi") in ..
  32. pmc Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas
    D Bergeron
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    J Virol 65:7-15. 1991
    The Cas-Br-E murine leukemia virus is a nondefective retrovirus that induces non-T-, non-B-cell lymphomas in susceptible NIH/Swiss mice...
  33. ncbi Determinants of foamy virus envelope glycoprotein mediated resistance to superinfection
    Angelika Berg
    Institut fur Virologie und Immunbiologie, Universitat Wurzburg, 97078 Wurzburg, Germany
    Virology 314:243-52. 2003
    ..This is in contrast to murine leukemia virus where secreted proteins comprising the receptor-binding domain in SU are sufficient to induce SIR...
  34. pmc Foamy virus envelope glycoprotein-mediated entry involves a pH-dependent fusion process
    Marcus Picard-Maureau
    Institut fur Virologie und Immunbiologie, Universitat Wurzburg, Germany
    J Virol 77:4722-30. 2003
    ..dependence of FV entry by analyzing FV envelope glycoprotein (Env)-mediated infection of target cells with murine leukemia virus or FV vector pseudotypes in the presence of various lysosomotropic agents...
  35. pmc The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter
    C A Wilson
    Laboratory of Molecular Tumor Biology, Food and Drug Administration, Rockville, Maryland 20892
    J Virol 69:534-7. 1995
    ..homolog in hamster cells functions as a receptor not only for amphotropic murine leukemia viruses and 10A1 murine leukemia virus but also for gibbon ape leukemia virus (C.A. Wilson, K. B. Farrell, and M. V. Eiden, J. Virol...
  36. ncbi High prevalence of an IgG response against murine leukemia virus (MLV) in patients with psoriasis
    Jean Pierre Moles
    Laboratoire de Dermatologie Moléculaire, Institut Universitaire de Recherche Clinique, 641 avenue du Doyen G Giraud, 34 093 Montpellier, Cedex 5, France
    Virus Res 94:97-101. 2003
    ..To assess a possible association of murine leukemia virus (MLV)-like group of HERVs with psoriasis we searched for antibodies against MLV proteins in the sera of ..
  37. pmc Murine leukemia virus particle assembly quantitated by fluorescence microscopy: role of Gag-Gag interactions and membrane association
    Mariam Andrawiss
    Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Science, University College London, London, United Kingdom
    J Virol 77:11651-60. 2003
    In order to track the assembly of murine leukemia virus (MLV), we used fluorescence microscopy to visualize particles containing Gag molecules fused to fluorescent proteins (FPs)...
  38. pmc Mutation in the glycosylated gag protein of murine leukemia virus results in reduced in vivo infectivity and a novel defect in viral budding or release
    Audrey Low
    Department of Molecular Biology and Biochemistry and Cancer Research Institute, University of California, Irvine, CA 92697 3905, USA
    J Virol 81:3685-92. 2007
    ..These results indicate that gPr80gag is important for M-MuLV replication in vivo and in vitro and that the protein may be involved in a late step in viral budding or release...
  39. pmc Characterization of hortulanus endogenous murine leukemia virus, an endogenous provirus that encodes an infectious murine leukemia virus of a novel subgroup
    Christopher H Tipper
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA
    J Virol 79:8316-29. 2005
    ..Previous work in our laboratory has been directed at dissecting the extensive nonecotropic murine leukemia virus content of the mouse genome...
  40. pmc Targeting of murine leukemia virus gag to the plasma membrane is mediated by PI(4,5)P2/PS and a polybasic region in the matrix
    E Hamard-Peron
    LaboRetro, INSERM U758, ENS de Lyon, IFR128, 69364 Lyon, France
    J Virol 84:503-15. 2010
    ..Gag proteins are targeted by a similar mechanism, we generated mutants of the matrix (MA) domain of murine leukemia virus (MuLV) Gag, examined their binding to membrane models in vitro, and analyzed their phenotypes in cell ..
  41. pmc Identification of a common helper provirus integration site in Abelson murine leukemia virus-induced lymphoma DNA
    Y Poirier
    Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada
    J Virol 62:3985-92. 1988
    Abelson murine leukemia virus induces oligoclonal pre-B lymphoma in mice...
  42. pmc Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer
    James N Baraniuk
    Georgetown University, 3800 Reservoir Road NW, Washington, DC 20007 2197, USA
    Curr Allergy Asthma Rep 10:210-4. 2010
    Xenotropic murine leukemia virus-related virus (XMRV) is a gamma retrovirus that has been associated with chronic fatigue syndrome (CFS) and prostate cancer...
  43. ncbi Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA
    S P Goff
    Cell 22:777-85. 1980
    Circular double-stranded DNA produced after infection of mouse cells with Abelson murine leukemia virus (A-MuLV) was isolated and cloned in the phage vector Charon 21A...
  44. pmc Allelism and linkage studies of murine leukemia virus activation genes in low leukemic strains of mice
    J McCubrey
    J Exp Med 155:1233-8. 1982
    Previously, we identified two genes, termed Inc-1 and Inb-1, that interact to enhance ecotropic murine leukemia virus induction in low virus strains of mice...
  45. ncbi The temperature stability of mouse retroviruses depends on the cholesterol levels of viral lipid shell and cellular plasma membrane
    Christiane Beer
    Molecular Biotechnology, GBF, Braunschweig, Germany
    Virology 308:137-46. 2003
    ..Finally, depletion of viral cholesterol in vitro resulted in intact virus with increased thermal stability. Thus, retrovirus lability depends on the host cell and parallels the cholesterol amount in the viral lipid shell...
  46. pmc Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses
    C S Tailor
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Proc Natl Acad Sci U S A 96:927-32. 1999
    ..We propose that X-MLVs and P-MLVs comprise a single family of retroviruses that have coevolved in response to diversification in X-receptor genes of the host...
  47. ncbi Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells
    Hiroaki Yoshii
    Department of AIDS Research, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Virology 394:227-34. 2009
    Recently it has been reported that a cathepsin B inhibitor, CA-074Me, attenuates ecotropic murine leukemia virus (Eco-MLV) infection in NIH3T3 cells, suggesting that cathepsin B is required for the Eco-MLV infection...
  48. pmc Trim5alpha protein restricts both HIV-1 and murine leukemia virus
    Melvyn W Yap
    Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 101:10786-91. 2004
    Replication of HIV-1 and N-tropic murine leukemia virus (N-MLV) is restricted in a number of different primate cells...
  49. pmc Intracellular trafficking of Gag and Env proteins and their interactions modulate pseudotyping of retroviruses
    Virginie Sandrin
    Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, INSERM U412, IFR128 Biosciences Lyon Gerland, Ecole Normal Supérieure de Lyon, France
    J Virol 78:7153-64. 2004
    ..from most retroviruses and from several families of enveloped viruses can form infectious pseudotypes with murine leukemia virus (MLV) and lentiviral core particles, like the MLV envelope glycoproteins (Env) that are incorporated on ..
  50. ncbi Retroviral genomic RNAs are transported to the plasma membrane by endosomal vesicles
    Eugenia Basyuk
    IGMM CNRS UMR5535, Universite Montpellier II, IFR 24, 1919, route de Mende, 34293 Cedex 5, Montpellier, France
    Dev Cell 5:161-74. 2003
    ..We show here that murine leukemia virus (MLV) RNAs are transported on lysosomes and transferrin-positive endosomes...
  51. pmc Efficient pseudotyping of murine leukemia virus particles with chimeric human foamy virus envelope proteins
    D Lindemann
    Institut für Virologie und Immunobiologie, Wurzburg, Germany
    J Virol 71:4815-20. 1997
    Incorporation of human foamy virus (HFV) envelope proteins into murine leukemia virus (MuLV) particles was studied in a transient transfection packaging cell system...
  52. pmc A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family
    M van Zeijl
    Molecular Biology Research Section, American Cyanamid Company, Pearl River, NY 10965
    Proc Natl Acad Sci U S A 91:1168-72. 1994
    ..Expression of this protein (GLVR-2) is likely to be a requirement for infection of human cells by amphotropic retroviral vectors for purposes of gene therapy...
  53. ncbi Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding
    Carolina Segura-Morales
    IGMM CNRS, 1919 Route de Mende 34293, Montpellier Cedex 5, France
    J Biol Chem 280:27004-12. 2005
    ..Here we show that the murine leukemia virus Gag has the unique ability to interact with all three factors...
  54. pmc Primer binding site-dependent restriction of murine leukemia virus requires HP1 binding by TRIM28
    Daniel Wolf
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, HHSC 1310, 701 West 168th Street, New York, NY 10032, USA
    J Virol 82:4675-9. 2008
    ..is a transcriptional corepressor which is required for primer binding site (PBS)-dependent restriction of murine leukemia virus (MLV) replication in embryonic stem and embryonic carcinoma (EC) cells...
  55. pmc Murine leukemia virus proviral insertions between the N-ras and unr genes in B-cell lymphoma DNA affect the expression of N-ras only
    J Martín-Hernández
    Department of Molecular and Structural Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Virol 75:11907-12. 2001
    Akv1-99, a variant of Akv murine leukemia virus, induces B-cell lymphomas with nearly 100% incidence and a mean latency period of 12 months after injection into newborn NMRI mice...
  56. pmc A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction
    J L Battini
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 96:1385-90. 1999
    ....
  57. ncbi Detection of reverse transcriptase activity in human melanoma cell lines and identification of a murine leukemia virus contaminant
    Martin Deichmann
    Department of Dermatology, Heidelberg University Clinics, Vossstrasse 2, 69115, Heidelberg, Germany
    Arch Dermatol Res 296:345-52. 2005
    ..Stimulated by earlier reports on the presence of retroviruses in mouse and hamster melanoma cell lines, we addressed the question as to whether human melanoma cell lines might also harbour a retrovirus...
  58. pmc Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice
    N A Jenkins
    J Virol 42:379-88. 1982
    BXH-2 recombinant inbred mice spontaneously produce a B-tropic murine leukemia virus (MuLV) beginning early in life and have a high incidence of non-T-cell lymphomas...
  59. pmc Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
    Rick S Mitchell
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Biol 2:E234. 2004
    ..vectors derived from human immunodeficiency virus (HIV), avian sarcoma-leukosis virus (ASLV), and murine leukemia virus (MLV)...
  60. pmc Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins
    Jenny L Anderson
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Ward 8 140, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Virol 80:9754-60. 2006
    ..Likewise, proteasome inhibition alleviated human TRIM5alpha restriction of N-tropic murine leukemia virus reverse transcription...
  61. pmc Chimeras of receptors for gibbon ape leukemia virus/feline leukemia virus B and amphotropic murine leukemia virus reveal different modes of receptor recognition by retrovirus
    L Pedersen
    Lederle Laboratories, American Cyanamid Company, Pearl River, New York 10965
    J Virol 69:2401-5. 1995
    ..Surprisingly, though GALV/FeLV-B and A-MLV belong to different interference groups, some chimeras functioned as receptors for all three viruses...
  62. ncbi Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors
    M van Lohuizen
    Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam
    Cell 56:673-82. 1989
    ..mice bearing the pim-1 gene supplemented with an upstream immunoglobulin enhancer and a downstream murine leukemia virus long terminal repeat express pim-1 mRNA at high levels in both B and T cells...
  63. pmc Capsid is a dominant determinant of retrovirus infectivity in nondividing cells
    Masahiro Yamashita
    Division of Human Biology, Mail Stop C2 023, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, P O Box 19024, Seattle, WA 98109 1024, USA
    J Virol 78:5670-8. 2004
    ..1 (HIV-1) in which the MA and CA of HIV-1 are replaced with the MA, p12, and CA encoding sequences from murine leukemia virus (MLV) loses the ability to efficiently infect nondividing cells...
  64. pmc Analysis of wild-derived mice for Fv-1 and Fv-2 murine leukemia virus restriction loci: a novel wild mouse Fv-1 allele responsible for lack of host range restriction
    C A Kozak
    J Virol 55:281-5. 1985
    ..Only M. spretus was resistant to virus-induced splenomegaly and did not restrict replication of Friend virus helper murine leukemia virus. Genetic studies confirmed that this mouse carries the resistance allele at Fv-2.
  65. pmc Variable regions A and B in the envelope glycoproteins of feline leukemia virus subgroup B and amphotropic murine leukemia virus interact with discrete receptor domains
    C S Tailor
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
    J Virol 71:9383-91. 1997
    The surface (SU) envelope glycoproteins of feline leukemia virus subgroup B (FeLV-B) and amphotropic murine leukemia virus (A-MLV) are highly related, even in the variable regions VRA and VRB that have been shown to be required for ..
  66. ncbi Intracellular versus cell surface assembly of retroviral pseudotypes is determined by the cellular localization of the viral glycoprotein, its capacity to interact with Gag, and the expression of the Nef protein
    Virginie Sandrin
    INSERM U412, Lyon Ecole Normale Supérieure de Lyon, and IFR128 BioSciences Lyon Gerland, Lyon, F 69007 France
    J Biol Chem 281:528-42. 2006
    ..quot; To further understand the mechanisms of pseudotyping, we have investigated the capacity of murine leukemia virus (MLV) or lentivirus core particles to recruit GPs derived from different virus families: the G protein of ..
  67. pmc A natural human retrovirus efficiently complements vectors based on murine leukemia virus
    Beihua Dong
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 3:e3144. 2008
    b>Murine Leukemia Virus (MLV) is a rodent gammaretrovirus that serves as the backbone for common gene delivery tools designed for experimental and therapeutic applications...
  68. pmc Microglial response to murine leukemia virus-induced encephalopathy is a good indicator of neuronal perturbations
    Qing Shan Xue
    Department of Neuroscience, PO Box 100244, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, FL 32610 0244, USA
    Brain Res 1319:131-41. 2010
    The neuronal pathology caused by neonatal infection of rats with the PVC-211 murine leukemia virus (PVC-211 MuLV) and its underlying mechanisms are not well defined even though a loss of neurons and spongiform neurodegeneration has been ..
  69. pmc Fv-4: identification of the defect in Env and the mechanism of resistance to ecotropic murine leukemia virus
    G M Taylor
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-1392, USA
    J Virol 75:11244-8. 2001
    ..Analysis of the mutant MuLV Env proteins also has implications for an understanding of the role of conserved glycine residues in fusion peptides and for the engineering of organismal resistance to retroviruses...
  70. ncbi Murine leukemia virus transmembrane protein R-peptide is found in small virus core-like complexes in cells
    Klaus Bahl Andersen
    Department of Pharmacology and Pharmacotherapy, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    J Gen Virol 87:1583-8. 2006
    The core of the retrovirus Murine leukemia virus (MLV) consists of the Gag precursor protein and viral RNA...
  71. pmc Mechanical properties of murine leukemia virus particles: effect of maturation
    Nitzan Kol
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Biophys J 91:767-74. 2006
    ..Here, we study the mechanical properties of live mature and immature murine leukemia virus particles by indentation-type experiments conducted with an atomic force microscope tip...
  72. pmc A unique sequence related to the ecotropic murine leukemia virus is associated with the Fv-4 resistance gene
    C A Kozak
    Proc Natl Acad Sci U S A 81:834-7. 1984
    ..allele at the Fv-4 locus (Fv-4r) that is responsible for resistance to infection by exogenous ecotropic murine leukemia virus. We have used blot hybridization with a probe specific for the ecotropic viral envelope to show that a ..
  73. ncbi Effect of Abelson murine leukemia virus on granulocytic differentiation and interleukin-3 dependence of a murine progenitor cell line
    G Rovera
    Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
    Oncogene 1:29-35. 1987
    ..Infection with Abelson murine leukemia virus (A-MuLV) of 32D Cl3 cells growing in the presence of IL-3 induces, within 2 weeks, the appearance of cells ..
  74. pmc Cellular transcription factor ZASC1 regulates murine leukemia virus transcription
    James W Bruce
    Institute for Molecular Virology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Virol 84:7473-83. 2010
    ..we employed a high-volume forward genetic screen of insertionally mutagenized somatic cells using a murine leukemia virus (MLV) vector...
  75. pmc Isolation of suppressor genes that restore retrovirus susceptibility to a virus-resistant cell line
    Guangxia Gao
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Retrovirology 1:30. 2004
    ..These selections have been used to recover lines that block early postentry stages of infection, either before reverse transcription or before nuclear entry. The mechanisms of action of these blocks remain unknown...
  76. ncbi Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse chromosome 4
    J P Stoye
    National Institute for Medical Research, Ridgeway, Mill Hill, London, UK
    Mamm Genome 6:31-6. 1995
    ..Three markers, Xmv9, Nppa, and Iap3rc11, were identified that showed no recombination with Fv1. By combining backcross and recombinant inbred strain data, we estimated that Xmv9 and Nppa must lie within 0.6 cM of one another and Fv1...
  77. pmc The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities
    Zuzana Keckesova
    Wohl Virion Center, Division of Infection and Immunity, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 101:10780-5. 2004
    ..Expression of TRIM5alpha in permissive cat cells renders them resistant to restriction-sensitive murine leukemia virus but not closely related insensitive virus...
  78. pmc Amphotropic murine leukemia virus is preferentially attached to cholesterol-rich microdomains after binding to mouse fibroblasts
    Christiane Beer
    Institute of Clinical Medicine and Department of Molecular Biology, University of Aarhus, Aarhus, Denmark
    Virol J 3:21. 2006
    We have recently shown that amphotropic murine leukemia virus (A-MLV) can enter the mouse fibroblast cell line NIH3T3 via caveola-dependent endocytosis...
  79. pmc The p12 domain is unstructured in a murine leukemia virus p12-CA(N) Gag construct
    SAMPSON K KYERE
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1902. 2008
    ..Here we show using nuclear magnetic resonance, that p12 is unstructured in a Moloney murine leukemia virus (MMLV) Gag fragment that includes the N-terminal domain of CA (p12-CA(N))...
  80. pmc Onset and dynamics of osteosclerosis in mice induced by Reilly-Finkel-Biskis (RFB) murine leukemia virus. Increase in bone mass precedes lymphomagenesis
    J Schmidt
    Institute of Molecular Virology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Am J Pathol 155:557-70. 1999
    Newborn NMRI strain mice were infected with Reilly-Finkel-Biskis (RFB) murine leukemia virus (MuLV), a murine leukemia virus that has been shown to induce lymphomas, osteosclerosis, and osteomas in susceptible strains of mice...
  81. pmc Gibbon ape leukemia virus and the amphotropic murine leukemia virus 4070A exhibit an unusual interference pattern on E36 Chinese hamster cells
    M A Eglitis
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892
    J Virol 67:5472-7. 1993
    ..These results imply the existence of a receptor on E36 cells that interacts with both GaLV and A-MLV...
  82. pmc Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains
    C A Kozak
    J Exp Med 155:524-34. 1982
    ..These studies provide further evidence that endogenous ecotropic V loci are present at different chromosomal sites in unrelated mouse strains and emphasize the role of germ line reinfections in the generation of this diversity...
  83. pmc Gris1, a new common integration site in Graffi murine leukemia virus-induced leukemias: overexpression of a truncated cyclin D2 due to alternative splicing
    Catherine Denicourt
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    J Virol 77:37-44. 2003
    The Graffi murine leukemia virus is a nondefective ecotropic retrovirus that was originally reported to induce myeloid leukemia in some strains of mice (A. Graffi, Ann. N.Y. Acad. Sci. 68:540-558, 1957)...
  84. ncbi Neutralizing activity and cellular immune responses induced in mice after immunization with apoptotic HIV-1/murine leukemia virus infected cells
    Jorma Hinkula
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
    Vaccine 27:6424-31. 2009
    ..We previously reported that immunizations with apoptotic HIV-1/murine leukemia virus (MuLV) infected cells lead to induction of both cellular and humoral immune responses as well as ..
  85. pmc Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning
    A L Nielsen
    Department of Molecular Biology, Aarhus University, Denmark
    Mol Cell Biol 12:3449-59. 1992
    The enhancer region of Akv murine leukemia virus contains the sequence motif ACAGATGG. This sequence is homologous to the E-box motif originally defined as a regulatory element in the enhancers of immunoglobulin mu and kappa genes...
  86. pmc Factors affecting the direct targeting of murine leukemia virus vectors containing peptide ligands in the envelope protein
    Masumi Katane
    Molecular Cell Science Laboratory, RIKEN, Wako, Saitama, Japan
    EMBO Rep 3:899-904. 2002
    ..of retroviral vectors, we genetically modified the envelope (Env) protein of the ecotropic Moloney murine leukemia virus. We found a site in the variable region A, where the insertion of ligands, epidermal growth factor (EGF) ..
  87. pmc Retrovirus restriction by TRIM5alpha variants from Old World and New World primates
    Byeongwoon Song
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA, USA
    J Virol 79:3930-7. 2005
    ..TRIM5alpha proteins functionally resembled human TRIM5alpha, potently restricting infection by N-tropic murine leukemia virus (N-MLV) and moderately restricting human immunodeficiency virus type 1 (HIV-1) infection...
  88. pmc Functional murine leukemia virus vectors pseudotyped with the visna virus envelope show expanded visna virus cell tropism
    L Bruett
    Division of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Virol 75:11464-73. 2001
    ..We describe the development of murine leukemia virus (MuLV) particles pseudotyped with the visna virus envelope glycoprotein and encoding a green fluorescent ..
  89. pmc A unique heparin-binding domain in the envelope protein of the neuropathogenic PVC-211 murine leukemia virus may contribute to its brain capillary endothelial cell tropism
    A Jinno-Oue
    Basic Research Laboratory, National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, USA
    J Virol 75:12439-45. 2001
    Previous studies from our laboratory demonstrated that PVC-211 murine leukemia virus (MuLV), a neuropathogenic variant of Friend MuLV (F-MuLV), had undergone genetic changes which allowed it to efficiently infect rat brain capillary ..
  90. ncbi Single amino acid changes in the murine leukemia virus capsid protein gene define the target of Fv1 resistance
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Virology 225:300-5. 1996
    ..Substitution of leucine for arginine at this site produced a virus with an unusual tropism not characteristic of any of the naturally occurring or laboratory strains of MuLV...
  91. pmc Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients
    Oliver Hohn
    Robert Koch Institute, Centre for Biological Safety 4, Nordufer 20, 13353 Berlin, Germany
    Retrovirology 6:92. 2009
    A novel gammaretrovirus named xenotropic murine leukemia virus-related virus (XMRV) has been recently identified and found to have a prevalence of 40% in prostate tumor samples from American patients carrying a homozygous R462Q mutation ..
  92. pmc Expression of murine leukemia virus envelope protein is sufficient for the induction of apoptosis
    Xiaoqing Zhao
    Department of Immunology and Microbiology, Wayne State University, 540 E Canfield Ave, Detroit, MI 48201, USA
    J Virol 82:2586-9. 2008
    ....
  93. pmc Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, 455 First Ave, New York, NY 10021, USA
    J Virol 79:8969-78. 2005
    ..Human TRIM5alpha (huTRIM5alpha) inhibits infection by N-tropic murine leukemia virus (N-MLV) but is inactive against human immunodeficiency virus type 1 (HIV-1)...
  94. pmc The prion protein gene is dispensable for the development of spongiform myeloencephalopathy induced by the neurovirulent Cas-Br-E murine leukemia virus
    P Jolicoeur
    Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada
    J Virol 70:9031-4. 1996
    The Cas-Br-E murine leukemia virus (MuLV) induces paralysis in susceptible mice that is accompanied by a severe spongiform myeloencephalopathy. These neurodegenerative lesions are very similar to those observed in prion diseases...
  95. pmc Localization of the amphotropic murine leukemia virus receptor gene to the pericentromeric region of human chromosome 8
    J V Garcia
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    J Virol 65:6316-9. 1991
    ..Here we report that by using human-Chinese hamster somatic cell hybrids and a retroviral vector, we have mapped the receptor for the amphotropic murine leukemia virus to the pericentromeric region of human chromosome 8.
  96. pmc Molecular and phylogenetic analyses of a new amphotropic murine leukemia virus (MuLV-1313)
    Thomas M Howard
    Laboratory of Viral Oncology and Proteomics Research, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032 3626, USA
    Virol J 3:101. 2006
    ....
  97. pmc Distinct mechanisms of neutralization by monoclonal antibodies specific for sites in the N-terminal or C-terminal domain of murine leukemia virus SU
    Michael Dominic Burkhart
    Laboratory of Retroviral Biology, Public Health Research Institute, Newark, New Jersey 07103 3535, USA
    J Virol 77:3993-4003. 2003
    The epitope specificities and functional activities of monoclonal antibodies (MAbs) specific for the murine leukemia virus (MuLV) SU envelope protein subunit were determined...
  98. ncbi Effects of LP-BM5 murine leukemia virus infection on errors and response time in a two-choice serial reaction time task in C57BL/6 mice
    Buyean Lee
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Brain Res 948:1-7. 2002
    ..Inoculation with the LP-BM5 murine leukemia virus (MuLV) causes profound immunosuppression (murine acquired immunodeficiency syndrome, or MAIDS) in C57BL/6 ..
  99. pmc The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid
    Michel J Perron
    Dana Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA
    J Virol 81:2138-48. 2007
    The host cell factors TRIM5alpha(hu) and Fv-1 restrict N-tropic murine leukemia virus (N-MLV) infection at an early postentry step before or after reverse transcription, respectively...
  100. pmc Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis
    Wai Tsing Chan
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 3:e2713. 2008
    ..Retroviruses have been observed to bud intracellularly into multivesicular bodies (MVB), in addition to the plasma membrane. Release from MVB is thought to occur by Ca(2+)-regulated fusion with the plasma membrane...
  101. ncbi Characterization of R peptide of murine leukemia virus envelope glycoproteins in syncytium formation and entry
    Y Kubo
    Department of AIDS Research, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Arch Virol 152:2169-82. 2007
    The C-terminal R peptide of ecotropic murine leukemia virus (MLV) envelope protein (Env) negatively controls membrane fusion activity...

Research Grants64

  1. The role of XMRV, a newly discovered human retrovirus, in cancer pathogenesis
    Ila R Singh; Fiscal Year: 2013
    ..viral nucleic acids in prostate cancer tissues led to the identification of a novel retrovirus, Xenotropic murine leukemia virus-related virus (XMRV) in approximately 10% of prostate cancers tested (5)...
  2. Molecular Biology of Eukaryotic Viruses
    Bert L Semler; Fiscal Year: 2012
    ..The viruses/viral systems being studied include murine leukemia virus, a sheep retrovirus (JSRV), HIV, yeast Ty3, poliovirus, human rhinovirus, coxsackievirus, mouse hepatitis ..
  3. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward H Egelman; Fiscal Year: 2012
    ..The proposed focus is on capsid proteins from bacteriophage P22, Infectious Bursal Disease Virus, and Murine Leukemia virus. PUBLIC HEALTH RELEVANCE This project is aimed at understanding structure/function relationships in large ..
  4. Southern Community Cohort Study
    Wei Zheng; Fiscal Year: 2013
    ..D, specific infections (Chlamydia pneumoniae, Trichomonas vaginalis, Helicobacter pylori, and xenotropic murine leukemia virus-related virus), several nutrition-related pathways (one carbon metabolism, n-6 and n-3 polyunsaturated ..
  5. Endogenous Retroviruses and the Immune Response to Pathogens
    JAQUELIN PAGE DUDLEY; Fiscal Year: 2013
    ..mice are more resistant to specific viral and bacterial pathogens, including exogenous MMTV, Friend murine leukemia virus, and the gram- negative bacterium, Vibrio cholerae, compared to the parental BALB/c strain...
  6. The in vivo function of A3A and A3G during retrovirus infection
    Spyridon Stavrou; Fiscal Year: 2013
    ..We will thus use these transgenic mice to test their effects on mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV) infection, retroviruses for which the mouse is the natural host and which are only partially ..
  7. Nanoparticle Analysis of Enveloped Virus Entry Pathways
    Robert Davey; Fiscal Year: 2009
    ..In this proposal, we will optimize techniques to construct fluorescent NPs coated in the envs of Friend murine leukemia virus, Venezuelan equine encephalitis virus (NIH category B agent) and Ebola (NIH category An agent)...
  8. MOUSE MODELS FOR UNDERSTANDING HOST RESPONES TO INTRACELLULAR PATHOGENS
    Ellen A Robey; Fiscal Year: 2010
    ..virus) and other pathogens (Murine &Human cytomegalovirus, Murine herpes virus 68, Moloney Murine Leukemia Virus, Kaposi's Sarcoma Herpes Virus, Mouse Hepatitis Virus, Mouse Adeno Virus, Polyomavirus)...
  9. Receptor Trafficking in Entry of Murine Leukemia Viruses
    Robert A Davey; Fiscal Year: 2011
    ..To identify factors important for Murine leukemia virus entry we designed and screened a custom siRNA library targeting genes important for endocytosis and ..
  10. Optimization of XMRV and other MLV-related virus detection for screening of blood
    Graham Simmons; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Abstract Xenotropic murine leukemia virus-related virus (XMRV) is a newly identified gammaretrovirus linked to prostate cancer and chronic fatigue syndrome (CFS)...
  11. Recruitment of host noncoding RNAs by XMRV
    Sandra L Wolin; Fiscal Year: 2012
    ..The specific focus is on a new human retrovirus, called Xenotropic murine leukemia virus-related virus (XMRV), which was recently identified in some prostate tumors and in some patients with ..
  12. Directed Cell Fusion for the Treatment of Myocardial Infarction
    Brenda M Ogle; Fiscal Year: 2010
    ..We propose to co-opt the unique fusion capabilities of the Moloney murine leukemia virus (MuLV) to develop a method for increasing the frequency of fusion between stem cells and cardiomyocytes...
  13. Integration of Murine Retroviral Vectors
    Monica J Roth; Fiscal Year: 2013
    ..This is highlighted in the past month with the association of xenotropic murine leukemia virus-related virus (XMRV) with human diseases including chronic fatigue syndrome and prostate cancer...
  14. Role of cytokine induction in APOBEC3-mediated virus restriction
    CHIOMA OKEOMA; Fiscal Year: 2011
    ..Vif-deficient human immunodeficiency virus 1 (HIV-1), primate foamy virus (PFV), hepatitis B virus (HBV), murine leukemia virus (MuLV), and mouse mammary tumor virus (MMTV)...
  15. Translational Development of Replication-Competent Retrovirus Vectors
    Noriyuki Kasahara; Fiscal Year: 2013
    ..We have previously demonstrated that direct intratumoral injection of murine leukemia virus (MLV)- based replication-competent retrovirus (RCR) vector preparations can achieve tremendously efficient ..
  16. GENETICS OF MYELODYSPLASTIC SYNDROMES
    Matthew J Walter; Fiscal Year: 2013
    ..to leukemia development, we will infect Hspa9+/- or wild-type littermate mice with a modified Moloney murine leukemia virus (MOL4070LTR retrovirus, a well established AML model) and monitor mice for the development of AML...
  17. NMR STUDIES OF RETROVIRAL NUCLEIC ACID BINDING PROTEINS
    MICHAEL FINLEY SUMMERS; Fiscal Year: 2013
    ..During the current funding period, we obtained strong in vivo and in vitro evidence that the Moloney Murine Leukemia Virus (MLV) uses an RNA structural switch mechanism, in which high affinity nucleocapsid (NC - the protein ..
  18. Modeling HTLV-1 infection and cellular immune response in HLA-A2-transgenic mice
    Zafar K Khan; Fiscal Year: 2012
    ..Recently, a chimeric HTLV-1 virus has been developed that utilizes the envelope gene of the Moloney-murine leukemia virus thereby allowing fusion of the chimeric virus with murine cells...
  19. Using natural antibodies to improve vaccines
    JOHN J IACOMINI; Fiscal Year: 2013
    ..also led to an enhanced cytotoxic T lymphocyte anti-virus response following challenge of mice with murine leukemia virus- transformed cell lines expressing 1Gal...
  20. CONSTRUCTION AND ANALYSIS OF RETROVIRUS MUTANTS
    STEPHEN PAINE GOFF; Fiscal Year: 2013
    This proposal describes the genetic analysis of the Gag and Pol proteins of the Moloney murine leukemia virus and of the cellular host proteins with which they interact...
  21. Retroviral Integration &HDAC inhibitors
    Monica J Roth; Fiscal Year: 2012
    ..This new area of investigation is based on the observation that mutations within the Moloney murine leukemia virus integrase (M-MuLV IN) proteins can be compensated by the presence of histone deacetylase (HDAC) inhibitors ..
  22. Cloning of the vic1 gene, a novel retrovirus restriction factor
    Tatyana V Golovkina; Fiscal Year: 2012
    ..Like HIV, Mouse Mammary Tumor Virus (MMTV) and Murine Leukemia Virus (MuLV) are retroviruses that have evolved numerous mechanisms to avoid elimination by the immune systems ..
  23. Understanding how HIV-1 Vpu and HIV-2 Env stimulate virus release
    Paula M Cannon; Fiscal Year: 2010
    ..In addition, our studies with the simple retrovirus, murine leukemia virus (MLV), have identified a similar activity in its Env protein...
  24. Retrovirus cell-to-cell transmission
    WALTHER H MOTHES; Fiscal Year: 2013
    ..to the understanding of the biogenesis of virological synapses using a model retrovirus, the Friend murine leukemia virus (F-MLV)...
  25. Defining genetic pathways of plasma-cell neoplasia
    Siegfried Janz; Fiscal Year: 2013
    ..The studies in Aim 1 will rely on a modified Moloney murine leukemia virus, MOL4070LTR...
  26. Small animal model for XMRV infection
    Yasuhiro Ikeda; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): A novel human gammaretrovirus, entropic murine leukemia virus-related virus (XMRV), has been identified in association with familial cases of prostate carcinoma and in patients with chronic fatigue ..
  27. HIV Infection of Non-Dividing Cells
    Michael Emerman; Fiscal Year: 2010
    ..other lentiviruses infect cells independent of cell- cycle progression, but gammaretroviruses such as the murine leukemia virus (MLV) require passage of cells through mitosis...
  28. Role of Natural Pseudotyping with Other Viruses in HIV Transmission
    James E Hildreth; Fiscal Year: 2011
    ..of this proposal is that acquisition by HIV- 1 of the envelope glycoprotein of gammaretroviruses (murine leukemia virus-related viruses) in a process we call ""natural pseudotyping"" expands the cellular tropism of HIV-1 ..
  29. Role of Natural Pseudotyping with Other Viruses in HIV Transmission
    James E Hildreth; Fiscal Year: 2013
    ..of this proposal is that acquisition by HIV- 1 of the envelope glycoprotein of gammaretroviruses (murine leukemia virus-related viruses) in a process we call ""natural pseudotyping"" expands the cellular tropism of HIV-1 ..
  30. Chromosome translocation in pre B cells: the role of an alternate DNA structure
    SUSANNA MAXWELL LEWIS; Fiscal Year: 2013
    ..The relationship between palindromy and translocation in mouse pro B cell lines (transformed by Abelson murine leukemia virus), and in a human pre-B line, Nalm6, will be investigated...
  31. Stem cell gene therapy for canine hemophilia
    Friedrich Schuening; Fiscal Year: 2002
    ..Transduction efficiency into hematopoietic stem cells of large animals and humans using Moloney murine leukemia virus (MoMLV) vectors has been too low so far to achieve a therapeutic effect...
  32. ANALYSIS OF CELLULAR ONCOGENES IN VIRUS-INDUCED TUMORS
    David Steffen; Fiscal Year: 1992
    ..Using thymic lymphomas induced in rats by Moloney murine leukemia virus (MoMLV), new oncogenes will be identified and characterized and the mechanism by which normal proto-..
  33. The Enzymology of M-MuLV and HIV Replication
    JAMES CHAMPOUX; Fiscal Year: 2009
    ..of hypotheses relating to the molecular details of human immunodeficiency virus type 1 (HIV-1) and Moloney murine leukemia virus (M-MuLV) replication...
  34. NEW RETROVIRAL RECEPTORS/HOST RESISTANCES
    David Kabat; Fiscal Year: 2004
    ..These investigations build on a technological breakthrough and will substantially expand our understanding of human and animal retroviral diseases and of host resistance mechanisms. ..
  35. MOLECULAR ENGINEERING OF RETROVIRAL VACCINES
    Edward Stephens; Fiscal Year: 1990
    The Friend murine leukemia virus (F-MuLV) is a replication competent retrovirus that is capable of causing erythroleukemia in newborn mice and can induce acute erythroleukemia in adult mice in association with replication defective ..
  36. ALPHA-1-PROTEASE INHIBITOR DEFICIENCY--GENE THERAPY
    Jerry Brown; Fiscal Year: 1991
    ..Three approaches will be tested to modify the Moloney murine leukemia virus (MoMLV) envelope protein to contain appropriate ligands for interaction with the ASGP receptor: 1) ..
  37. NCI CLINICAL INVESTIGATOR AWARD
    Kemp Cease; Fiscal Year: 1990
    The Abelson oncogene (abl) of the acutely transforming Abelson Murine Leukemia Virus (AMLV) has been intensively studied since its original discovery...
  38. IMPROVED METHODS FOR IN VIVO HEPATIC GENE THERAPY
    KATHERINE PONDER; Fiscal Year: 2006
    ..and result in long-term and therapeutic levels of expression in rodents, both the older Moloney murine leukemia virus (MLV) vectors as well as the newer lentiviral vectors only efficiently transduce dividing hepatocytes...
  39. Fetal Stem Cell Gene Therapy
    MARCUS MUENCH; Fiscal Year: 2003
    ..and are, therefore, hypothesized to be more susceptible to transduction by retroviral vectors based on murine leukemia virus or human immunodeficiency virus...
  40. TRANSFORMATION AND DIFFERENTIATION BY V AND C ABL GENES
    E Reddy; Fiscal Year: 1992
    The c-abl gene is the cellular homolog of the transforming component (v-abl) of Abelson Murine leukemia virus. In an effort to understand the molecular mechanisms involved in the activation of this oncogene, we and others have recently ..
  41. MOUSE RETROVIRUS CO-OPTING OF IMMUNE CELL INTERACTIONS
    William Green; Fiscal Year: 2005
    ..abstract_text> ..
  42. BIOCHEMICAL AND GENETIC STUDIES OF MULV ENV PROTEINS
    Abraham Pinter; Fiscal Year: 1991
    The murine leukemia virus (MuLV) env gene is an important determinant of viral infectivity, and the products of this gene provide useful models for studying the biosynthetic pathways of membrane proteins...
  43. ROLE OF AUTOREACTIVE T CELLS IN MURINE AIDS
    Mohan Sopori; Fiscal Year: 1993
    ..certain aspects, for AIDS, C57BL/6 mice are infected with a mixture of ecotropic and replication defective murine leukemia virus strains...
  44. HIV vectors for stem cell and intrakine gene delivery
    Richard Sutton; Fiscal Year: 2004
    ..Vectors based upon murine leukemia virus (MLV) have been widely used as gene transfer vehicles...
  45. ANTI AKR/GROSS MULV CTL--MECHANISMS OF NONRESPONSIVENESS
    William Green; Fiscal Year: 2004
    ..In this proposal we intend to extend our ongoing studies which utilize weakly immunogenic, AKR/Gross murine leukemia virus (MULV) induced tumor cells as a model system for examining cell-mediated anti-tumor immunity...
  46. TRANSDUCTION OF HUMAN HEMATOPOIETIC STEM CELLS
    Gay Crooks; Fiscal Year: 2001
    ..The low efficiency of transduction using Moloney Murine Leukemia Virus (MoMuLV) based vectors is assumed to be secondary to non- integration of provirus into the genomes of ..
  47. PATHOGENESIS OF RETROVIRAL INFECTION OF THE CNS
    Clayton Wiley; Fiscal Year: 1993
    ..Approximately twenty years ago a neurotropic ecotropic murine leukemia virus was isolated from paralyzed feral mice...
  48. MECHANISMS OF RETROVIRUS INDUCED T AND NEURAL CELL DEATH
    Paul Wong; Fiscal Year: 2003
    ..to understand the pathogenic mechanism of neuroimmunodegeneration (NID) induced by a mutant of the Moloney murine leukemia virus, ts1...
  49. Control of retrovirus CNS disease by redox modulation
    Paul K Wong; Fiscal Year: 2010
    ..In our model of HAD, FVB/N mice are infected with a mutant of the Moloney murine leukemia virus, called te1, which causes progressive neuroimmunodegeneration that is in many ways similar to that of HAD...
  50. GENOMIC DETERMINANTS OF MURINE LEUKEMIA VIRUS
    Alice Telesnitsky; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The proposed research examines Moloney murine leukemia virus as a model system for testing determinants and outcomes of general and specific features of retroviral genome structure...
  51. Transcriptional repression in leukemia
    H Grimes; Fiscal Year: 2007
    ..GFI1 was originally identified as a frequent target of Moloney murine leukemia virus insertion in rat and mouse genomes...
  52. Molecular Analysis of Murine Leukemia Virus Entry
    Lorraine Albritton; Fiscal Year: 2007
    ..abstract_text> ..
  53. ETIOLOGIC ROLE OF TNF/FAS ON AN AIDS-LIKE CNS DISEASE
    Paul Wong; Fiscal Year: 2000
    ..relies on the use of a murine model of neurodegeneration in which infection of a mutant form of Moloney Murine Leukemia Virus (MoMuLV) induces a progressive neuroimmunodegenerative disease (NID) that has some clinical and ..
  54. HIV-1 AND HIV-2 INFECTION OF NON-DIVIDING CELLS
    ROBERT DOMS; Fiscal Year: 2003
    ..in non-dividing cells is a feature of the HIVs that is not shared by oncogenic retroviruses such as murine leukemia virus (MLV)...
  55. CELLULAR IMMUNITY TO ENDOGENOUS AKR LEUKEMIA VIRUSES
    William Green; Fiscal Year: 1993
    ..Because it is widely thought that CTL are particularly effective against virus infected cells and tumor cells, it is important to understand to which MuLV CTL can be directed and their molecular specificity...
  56. VARIATION, IMMUNE ESCAPE, AND PATHOGENESIS OF MULV
    William Green; Fiscal Year: 2000
    ..Information gained will advance the understanding of AKR/Gross MuLV- induced leukemogenesis and may have relevance to tumors in higher species, including ATL/HTLV-I in man. ..
  57. SITE-SPECIFIC MODIFICATION OF SFFV GLYCOPROTEINS
    RANGA SRINIVAS; Fiscal Year: 1991
    ..of a recombinant envelope gene that shows substitutions, deletions and insertions when compared to related murine leukemia virus (MuLV) envelope genes...
  58. INTRAMARROW GENE TRANSFER IN NEONATES
    Bruce Bunnell; Fiscal Year: 2003
    ..The investigators will explore the most effective vector system (Moloney murine leukemia virus {MLV} versus HIV-1-derived lentivirus), the effects of cytokines on the in vivo transduction efficiency of ..
  59. SPECIFICITY OF THE CTL RESPONSE TO MURINE LEUKEMIA VIRUS
    DAVID FLYER; Fiscal Year: 1992
    ....
  60. GENOMIC DETERMINANTS OF MURINE LEUKEMIA VIRUS
    Alice Telesnitsky; Fiscal Year: 2000
    ..examines general and specific parameters that influence retroviral genome structure, using Moloney murine leukemia virus as a model system...
  61. RETROVIRUS PARTICLE DISPLAY FOR IMMUNOGEN OPTIMIZATION
    SAMUEL KAYMAN; Fiscal Year: 1999
    We propose to use a novel murine leukemia virus (MuLV)-based retroviral display system that we have recently developed (mss in prep) to improve our HIV-1 humoral vaccine candidate, which is based on the V1V2 domain of gpl20...
  62. ROLE OF MURINE LEUKEMIA VIRUS IN AUTOIMMUNITY
    Seth Pincus; Fiscal Year: 2001
    ..The third aim is to correlate the expression of the antibody response to the retrovirus with the production of autoantibodies and to determine whether the anti-retrovirus antibodies are present in immune complexes from diseased kidneys. ..
  63. MODIFIED RETROVIRAL VECTORS FOR HSC GENE THERAPY
    Donald Kohn; Fiscal Year: 2000
    ..retroviral LTRs, MND and MTD, showed significantly improved expression, compared to the standard Moloney Murine Leukemia virus (MLV) LTR, in murine ES cells and in murine hematopoietic and lymphoid cells...
  64. CYTOKINE SIGNALING AND ABL INDUCED TRANSFORMATION
    Paul Rothman; Fiscal Year: 2002
    We have previously shown that murine pre-B cell lines transformed with the Abelson murine leukemia virus (A-MuLV) exhibit constitutive, ligand independent, activation of the IL-4 and IL-7 JAK-STAT signaling pathways...