mason pfizer monkey virus

Summary

Summary: A species of BETARETROVIRUS isolated from mammary carcinoma in rhesus monkeys. It appears to have evolved from a recombination between a murine B oncovirus and a primate C oncovirus related to the baboon endogenous virus. Several serologically distinct strains exist. MPMV induces simian AIDS (SAIDS).

Top Publications

  1. ncbi M-PMV capsid transport is mediated by Env/Gag interactions at the pericentriolar recycling endosome
    Jeffrey N Sfakianos
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Traffic 4:671-80. 2003
  2. pmc The pp24 phosphoprotein of Mason-Pfizer monkey virus contributes to viral genome packaging
    Christopher R Bohl
    School of Biological Sciences, The Nebraska Center for Virology, University of Nebraska, Lincoln, 68588, USA
    Retrovirology 2:68. 2005
  3. pmc The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking
    Vincent Blot
    Institut Cochin, Département Biologie Cellulaire, Paris, F 75014 France
    Retrovirology 3:62. 2006
  4. pmc Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1
    H P Bogerd
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 72:8627-35. 1998
  5. ncbi Localization of self-interacting domains within betaretrovirus Gag polyproteins
    Ales Zábranský
    Department of Protein Biochemistry, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n 2, Prague 6, 16610, Czech Republic
    Virology 332:659-66. 2005
  6. ncbi Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors
    Juraj Hlavaty
    Research Institute of Virology and Biomedicine, University of Veterinary Medicine, A 1210 Vienna, Austria
    Virology 341:1-11. 2005
  7. ncbi The M-PMV cytoplasmic targeting-retention signal directs nascent Gag polypeptides to a pericentriolar region of the cell
    Jeffrey N Sfakianos
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Traffic 4:660-70. 2003
  8. pmc The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release
    Eva Gottwein
    Abteilung Virologie, Universitatsklinikum Heidelberg, D 69120 Heidelberg, Germany
    J Virol 77:9474-85. 2003
  9. ncbi Mason-Pfizer monkey virus Gag proteins interact with the human sumo conjugating enzyme, hUbc9
    Robert A Weldon
    School of Biological Sciences and the Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68588 0666, USA
    Virology 314:62-73. 2003
  10. pmc Novel mouse type D endogenous proviruses and ETn elements share long terminal repeat and internal sequences
    D L Mager
    Terry Fox Laboratory, British Columbia Cancer Agency, and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Virol 74:7221-9. 2000

Research Grants

  1. Evaluation of RNA transport elements in HIV-1 vectors
    SRINIVAS KUMAR; Fiscal Year: 2007
  2. SIMIAN RETROVIRUSES--NOVEL GENE DELIVERY VECTORS
    CURTIS MACHIDA; Fiscal Year: 1999
  3. GENETICS OF PRIMATE D TYPE RETROVIRUSES
    Eric Hunter; Fiscal Year: 1999
  4. GENETICS OF PRIMATE D TYPE RETROVIRUSES
    Eric Hunter; Fiscal Year: 2001
  5. REGULATION OF HIV RNA PROCESSING AND TRANSPORT
    Marie Louise Hammarskjold; Fiscal Year: 2002
  6. HOST CELL PROTEINS IN RETROVIRAL ASSEMBLY & TRANSPORT
    Rachel LaCasse; Fiscal Year: 2002
  7. Sam 68 and the Function of Mason Pfizer Monkey Virus CTE
    Marie Louise Hammarskjold; Fiscal Year: 2007
  8. IN VITRO ASSEMBLY AND INHIBITION OF HIV CAPSIDS
    Michael Sakalian; Fiscal Year: 2001
  9. TRAINING IN VIRAL ONCOLOGY
    JANET MERTZ; Fiscal Year: 2005
  10. Regulation of Latent-Lytic Switch in EBV by ZEB
    JANET MERTZ; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications134 found, 100 shown here

  1. ncbi M-PMV capsid transport is mediated by Env/Gag interactions at the pericentriolar recycling endosome
    Jeffrey N Sfakianos
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Traffic 4:671-80. 2003
    ..Thus, for the first time, endocytic trafficking of a retroviral Env glycoprotein is linked to the efficient cytoplasmic transport of Gag...
  2. pmc The pp24 phosphoprotein of Mason-Pfizer monkey virus contributes to viral genome packaging
    Christopher R Bohl
    School of Biological Sciences, The Nebraska Center for Virology, University of Nebraska, Lincoln, 68588, USA
    Retrovirology 2:68. 2005
    ..The function of the Np24 domain, however, is not known...
  3. pmc The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking
    Vincent Blot
    Institut Cochin, Département Biologie Cellulaire, Paris, F 75014 France
    Retrovirology 3:62. 2006
    ..Because both components are translated in different intracellular compartments, elucidating the mechanisms of retrovirus assembly thus requires the study of their intracellular trafficking...
  4. pmc Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1
    H P Bogerd
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 72:8627-35. 1998
    ..In addition, these data identify a novel and highly potent inhibitor of leucine-rich NES-dependent nuclear export...
  5. ncbi Localization of self-interacting domains within betaretrovirus Gag polyproteins
    Ales Zábranský
    Department of Protein Biochemistry, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n 2, Prague 6, 16610, Czech Republic
    Virology 332:659-66. 2005
    ..Our findings suggest that, in addition to the canonical NC "I-domain" interaction, MMTV Gag self-association results from the concerted action of multiple regions of the polyprotein while M-PMV Gag relies mainly on its p12 domain...
  6. ncbi Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors
    Juraj Hlavaty
    Research Institute of Virology and Biomedicine, University of Veterinary Medicine, A 1210 Vienna, Austria
    Virology 341:1-11. 2005
    ..These data suggest that only the WPRE is a suitable element for the improvement of transgene expression and oncoretroviral vector production...
  7. ncbi The M-PMV cytoplasmic targeting-retention signal directs nascent Gag polypeptides to a pericentriolar region of the cell
    Jeffrey N Sfakianos
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Traffic 4:660-70. 2003
    ..Thus the previously defined cytoplasmic targeting-retention signal appears to act as a cotranslational intracellular targeting signal that concentrates Gag proteins at the centriole for assembly of capsids...
  8. pmc The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release
    Eva Gottwein
    Abteilung Virologie, Universitatsklinikum Heidelberg, D 69120 Heidelberg, Germany
    J Virol 77:9474-85. 2003
    ..Consistent with a role of VPS4A in the budding of both PPPY and PTAP motif-containing viruses, the overexpression of ATPase-defective GFP-VPS4A fusion proteins blocked both wild-type and PSAP mutant virus release...
  9. ncbi Mason-Pfizer monkey virus Gag proteins interact with the human sumo conjugating enzyme, hUbc9
    Robert A Weldon
    School of Biological Sciences and the Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68588 0666, USA
    Virology 314:62-73. 2003
    ....
  10. pmc Novel mouse type D endogenous proviruses and ETn elements share long terminal repeat and internal sequences
    D L Mager
    Terry Fox Laboratory, British Columbia Cancer Agency, and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Virol 74:7221-9. 2000
    ..Furthermore, these results suggest that ETn transcripts retrotranspose using proteins provided by MusD proviruses...
  11. pmc Primate and feline lentivirus vector RNA packaging and propagation by heterologous lentivirus virions
    M T Browning
    Department of Veterinary Sciences, The University of Texas M D Anderson Cancer Center, Bastrop, Texas 78602, USA
    J Virol 75:5129-40. 2001
    ....
  12. ncbi dUTPase and nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion protein in the virion with homotrimeric organization and low catalytic efficiency
    Orsolya Barabas
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, POB 7, H 1518, Budapest, Hungary
    J Biol Chem 278:38803-12. 2003
    ..Binding of the hexanucleotide ACTGCC or the octanucleotide (TG)4 to NC-dUTPase modulates enzymatic function, indicating that the low catalytic activity may be compensated by adequate localization...
  13. pmc The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
    Y Kang
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 13:1126-39. 1999
    ..Together, these data validate Tap as the first human sequence-specific nuclear mRNA export factor and identify a novel type of NES that can support nuclear mRNA export but does not act via Crm1...
  14. ncbi The envelope of Mason-Pfizer monkey virus has immunosuppressive properties
    S Blaise
    , UMR 1573 CNRS, Institut Gustave Roussy, 94805 Villejuif, France
    J Gen Virol 82:1597-600. 2001
    ..Here, it is shown that this property is not restricted to the envelope of a murine retrovirus, but is also shared by the envelope encoded by a primate retrovirus, Mason-Pfizer monkey virus...
  15. ncbi Sequences within both the 5' untranslated region and the gag gene are important for efficient encapsidation of Mason-Pfizer monkey virus RNA
    Russell D Schmidt
    The University of Texas M D Anderson Cancer Center, Department of Veterinary Sciences, Bastrop, TX 78602, USA
    Virology 309:166-78. 2003
    ..Thus, sequences that affect MPMV RNA packaging seem to reside both upstream and downstream of the major splice donor with the downstream region responsible for the efficient functioning of the upstream primary packaging determinant...
  16. ncbi Integrase of Mason-Pfizer monkey virus
    Jan Snasel
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    FEBS J 272:203-16. 2005
    ....
  17. pmc Variable sensitivity to substitutions in the N-terminal heptad repeat of Mason-Pfizer monkey virus transmembrane protein
    Chisu Song
    Department of Microbiology and Center for AIDS Research, University of Alabama at Birmingham, 845 19th Street S, Birmingham, AL 35294, USA
    J Virol 77:7779-85. 2003
    ....
  18. pmc A tyrosine motif in the cytoplasmic domain of mason-pfizer monkey virus is essential for the incorporation of glycoprotein into virions
    Chisu Song
    Department of Microbiology, University of Alabama at Birmingham, 35294, USA
    J Virol 77:5192-200. 2003
    ..Antibody uptake studies show that tyrosine 22 is part of an efficient internalization signal in the cytoplasmic domain of the M-PMV glycoprotein that can also be positively and negatively influenced by changes at this site...
  19. pmc Persistence and dissemination of simian retrovirus type 2 DNA in relation to viremia, seroresponse, and experimental transmissibility in Macaca fascicularis
    Roseanne C Wilkinson
    Division of Retrovirology Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    J Virol 77:10751-9. 2003
    ..These results indicate that a proportion of M. fascicularis are able to effectively control the replication and infectivity of SRV despite long-term persistence of viral DNA forms in infected lymphocytes...
  20. pmc The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles
    Brian P Doehle
    Duke University Medical Center, Box 3025, Durham, NC 27710, USA
    J Virol 80:12102-8. 2006
    ....
  21. pmc The Mason-Pfizer monkey virus internal scaffold domain enables in vitro assembly of human immunodeficiency virus type 1 Gag
    Michael Sakalian
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Virol 76:10811-20. 2002
    ..This continued requirement for HIV Gag domain function in the assembly of chimeric molecules will allow this in vitro system to be used for the analysis of potential inhibitors of HIV immature particle assembly...
  22. pmc Viral late domains
    Eric O Freed
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Virol 76:4679-87. 2002
  23. pmc Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites
    Peter Bagossi
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    J Virol 79:4213-8. 2005
    ..In most cases the P2 residues of naturally occurring type 1 cleavage site sequences of the studied proteases agreed well with the observed P2 preferences...
  24. pmc Activity of the Mason-Pfizer monkey virus fusion protein is modulated by single amino acids in the cytoplasmic tail
    Chisu Song
    Department of Microbiology, University of Alabama at Birmingham, 35294, USA
    J Virol 79:11569-79. 2005
    ....
  25. ncbi Interacting partners of M-PMV nucleocapsid-dUTPase
    V Németh-Pongrácz
    Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary
    Nucleosides Nucleotides Nucleic Acids 25:1197-200. 2006
    ..Integrase protein is an important component within the preintegration complex; therefore the present results also suggest that NC-dUTPase might be associated with this complex...
  26. pmc Lentiviral vector design using alternative RNA export elements
    Taekeun Oh
    Department of Medicine, Kidney Disease Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Retrovirology 4:38. 2007
    ..Recent studies have attempted to replace the existing complex rev/RRE system with a more simplistic RNA export system from simple retroviruses to make these vectors in a rev-independent manner...
  27. ncbi Mutational analysis of the predicted secondary RNA structure of the Mason-Pfizer monkey virus packaging signal
    Farah Mustafa
    Department of Medical Microbiology, Faculty of Medicine and Health Sciences FMHS, The United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Virus Res 99:35-46. 2004
    ..Finally, results of the biological effects of the structural mutations are discussed in relation to their effects on the folding potential of the various stem loops...
  28. ncbi Close proximity of the MPMV CTE to the polyadenylation sequences is important for efficient function in the subgenomic context
    Farah Mustafa
    Department of Medical Microbiology, Faculty of Medicine and Health Sciences, The United Arab Emirates University, Al Ain, UAE
    Virus Res 105:209-18. 2004
    ..Our results reveal that similar to the genomic situation, close proximity of CTE to the polyadenylation sequences is important for its function in the heterologous subgenomic context...
  29. pmc Basic residues in the Mason-Pfizer monkey virus gag matrix domain regulate intracellular trafficking and capsid-membrane interactions
    Elizabeth Stansell
    Department of Pathology and Emory Vaccine Center at Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Virol 81:8977-88. 2007
    ..All mutants that released virions exhibited near-wild-type infectivity in a single-round assay. Thus, basic amino acids in the M-PMV MA define both cellular location and efficiency of virus release...
  30. pmc Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK
    John H Coyle
    Myles H Thaler Center for AIDS and Human Retrovirus Research and Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    Mol Cell Biol 23:92-103. 2003
    ..These results suggest that Sam68 may interact with specific RNAs in the nucleus to provide a "mark" that affects their cytoplasmic fate. They also provide further evidence of links between signal transduction and RNA utilization...
  31. pmc Identification of two intracellular mechanisms leading to reduced expression of oncoretrovirus envelope glycoproteins at the cell surface
    M P Grange
    INSERM U332, Institut Cochin de Genetique Moleculaire, 75014 Paris, France
    J Virol 74:11734-43. 2000
    ..These results indicate that retroviruses have evolved two distinct mechanisms to ensure a similar biological feature: low concentrations of their glycoproteins at the cell surface...
  32. ncbi An intron with a constitutive transport element is retained in a Tap messenger RNA
    Ying Li
    Myles H Thaler Center for AIDS and Human Retrovirus Research and Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 443:234-7. 2006
    ..Thus, CTEs are likely to be important elements that facilitate efficient expression of mammalian mRNAs with retained introns...
  33. pmc Trafficking through the Rev/RRE pathway is essential for efficient inhibition of human immunodeficiency virus type 1 by an antisense RNA derived from the envelope gene
    Alex M Ward
    Department of Microbiology, Myles H Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 83:940-52. 2009
    ..However, protein levels were significantly reduced. Taken together, our results suggest a new mechanism for antisense inhibition of HIV mediated by Rev/RRE...
  34. ncbi Nucleocytoplasmic export of type D simian retrovirus genomic RNA: identification of important genetic subregions and interacting cellular proteins
    B Li
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    Virology 264:37-54. 1999
    ..These experiments indicate that secondary structural determinants of the 3' IR and multiple protein interactions may be important factors in the nuclear export of unspliced SRV RNA...
  35. pmc The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function
    C Tabernero
    Human Retrovirus Pathogenesis Group, ABL Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    J Virol 70:5998-6011. 1996
    ..These data further support our in vitro mutagenesis data and demonstrate the importance of the sequence and structure of the SRV-1 CTE for appropriate function...
  36. pmc Novel Tat-encoding bicistronic human immunodeficiency virus type 1-based gene transfer vectors for high-level transgene expression
    N Srinivasakumar
    Division of Hematology Oncology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232 6305, USA
    J Virol 74:6659-68. 2000
    ....
  37. ncbi Isolation and characterization of the Mason-Pfizer monkey virus p12 protein
    Zdenek Knejzlík
    Department of Biochemistry and Microbiology and Center for Integrated Genomics, Institute of Chemical Technology, 166 28 Prague, Czech Republic
    Virology 324:204-12. 2004
    ..The data show that both domains of p12 contribute to its ability to multimerize with much of this potential residing in its N-terminal part, most probably within the leucine zipper-like (LZL) sequence...
  38. pmc Protein of macaques against infection with simian type D retrovirus (SRV-1) by immunization with recombinant vaccinia virus expressing the envelope glycoproteins of either SRV-1 or Mason-Pfizer monkey virus (SRV-3)
    B A Brody
    Department of Microbiology, University of Alabama, Birmingham 35294
    J Virol 66:3950-4. 1992
    ..These findings are consistent with the known degree of serologic and genetic relatedness of these three SRV strains...
  39. ncbi The endogenous langur type D retrovirus PO-1-Lu and its exogenous counterparts in macaque and langur monkeys
    Maja A Sommerfelt
    Centre for Research in Virology, Department of Microbiology and Immunology, The Gade Institute, University of Bergen, Bergen High Technology Centre, N 5020 Bergen, Norway
    Virology 315:275-82. 2003
    ..obscurus) has previously been considered a progenitor to the prototype type D retrovirus, Mason Pfizer monkey virus (M-PMV/SRV-3), that became established in macaque monkeys (Macaca spp.) following a zoonosis...
  40. pmc Nedd4 regulates egress of Ebola virus-like particles from host cells
    Jiro Yasuda
    Division of Molecular Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita ku, Sapporo 060 0815, Japan
    J Virol 77:9987-92. 2003
    ..As expected, Tsg101 enhanced VP40-induced VLP release, and TsgDeltaC, which lacks its C-terminal half, inhibited VLP release. These results indicate that Nedd4, together with Tsg101, plays an important role in Ebola virus budding...
  41. ncbi Role of matrix protein in the type D retrovirus replication cycle: importance of the arginine residue at position 55
    J Yasuda
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, 35294 2170, USA
    Virology 268:533-8. 2000
    ....
  42. ncbi Use of polymerase chain reaction for diagnosis of type D simian retrovirus infection in macaque blood
    Y Wang
    Regional Primate Research Center, University of Washington, Seattle 98195 7238, USA
    Lab Anim Sci 46:187-92. 1996
    ..The PCR analysis of 39 whole blood samples correctly identified five SRV-1 and nine SRV-2 culture-positive samples. It also detected SRV-2 in two culture-negative blood samples from monkeys from which SRV had been previously isolated...
  43. ncbi Viral interactions with the nuclear transport machinery: discovering and disrupting pathways
    Beatriz Ma Fontoura
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    IUBMB Life 57:65-72. 2005
    ..Hence, this review focuses on viruses as tools and as disruptors of nucleocytoplasmic trafficking...
  44. ncbi The use of primers from highly conserved pol regions to identify uncharacterized retroviruses by the polymerase chain reaction
    L A Donehower
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030
    J Virol Methods 28:33-46. 1990
    ..Our PCR assay identified the retrovirus as being highly similar to Mason-Pfizer monkey virus (MPMV) and simian retrovirus 1, which are closely related immunosuppressive type D viruses that cause simian AIDS...
  45. ncbi Engineered retroviral virus-like particles for receptor targeting
    Irena Voráčková
    Department of Biochemistry and Microbiology, Institute of Chemical Technology Prague, Technicka 5, 166 28, Prague 6, Czech Republic
    Arch Virol 159:677-88. 2014
    ....
  46. pmc Rev-free HIV-1 gene delivery system for targeting Rev-RRE-Crm1 nucleocytoplasmic RNA transport pathway
    Narasimhachar Srinivasakumar
    Division of Hematology Oncology, Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri, United States of America
    PLoS ONE 6:e28462. 2011
    ..This Rev-free packaging system may prove useful for targeting the Rev-RRE-Crm1 nucleocytoplasmic RNA transport pathway for inhibiting HIV replication...
  47. pmc ROCK1 and LIM kinase modulate retrovirus particle release and cell-cell transmission events
    Xiaoyun Wen
    Department of Pediatrics, Children s Healthcare of Atlanta and Emory University School of Medicine, Atlanta, Georgia, USA
    J Virol 88:6906-21. 2014
    ..Our studies support a model in which ROCK1- and LIMK1-regulated phosphorylation of cofilin and subsequent local disruption of dynamic actin turnover play a role in retrovirus release from host cells and in cell-cell transmission events...
  48. pmc Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly
    Tanmay A M Bharat
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany Molecular Medicine Partnership Unit, European Molecular Biology Laboratory Universitätsklinikum Heidelberg, Heidelberg, Germany Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 111:8233-8. 2014
    ..Our results reveal a hollow column of density for this region in HIV-1 that is compatible with the presence of a six-helix bundle at this position. ..
  49. pmc Human Ubc9 contributes to production of fully infectious human immunodeficiency virus type 1 virions
    Tareq Jaber
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68583 0900, USA
    J Virol 83:10448-59. 2009
    ..This finding demonstrates that Ubc9 plays an important role in the production of infectious HIV-1 virions...
  50. ncbi Mason-Pfizer monkey virus (MPMV) constitutive transport element (CTE) functions in a position-dependent manner
    T A Rizvi
    Department of Veterinary Sciences, The University of Texas M D Anderson Cancer Center, Bastrop, Texas 78602, USA
    Virology 236:118-29. 1997
    ..Together, these results demonstrate that the close proximity of CTE to the poly(A) signal is important for CTE function, suggesting a functional interaction between CTE and the polyadenylation machinery...
  51. ncbi Role of a heterologous retroviral transport element in the development of genetic complementation assay for mouse mammary tumor virus (MMTV) replication
    Tahir A Rizvi
    Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences FMHS, United Arab Emirates University UAEU, P O Box 17666, Al Ain, UAE
    Virology 385:464-72. 2009
    ..has been successfully substituted by a heterologous retroviral constitutive transport element (CTE) from Mason Pfizer Monkey Virus (MPMV) for mature MMTV particle production...
  52. pmc The structure of myristoylated Mason-Pfizer monkey virus matrix protein and the role of phosphatidylinositol-(4,5)-bisphosphate in its membrane binding
    Jan Prchal
    Laboratory of NMR Spectroscopy, Institute of Chemical Technology, Prague, Technicka 5, 16628 Prague, Czech Republic
    J Mol Biol 423:427-38. 2012
    ..PI(4,5)P(2) binding was not strong enough for triggering of the myristoyl-switch. The structural changes of the myristoylated matrix protein were also found to result in a drop in the oligomerization capacity of the protein...
  53. ncbi The Mhc class II DRB genotype of Macaca fascicularis does not influence infection by simian retrovirus type 2
    E T Mee
    Division of Retrovirology, National Institute for Biological Standards and Control, Hertfordshire, UK
    Tissue Antigens 72:369-78. 2008
    ..A discordance with SRV-2 infection status suggests that an Mhc II DRB genotype is not overtly associated with the outcome of viral infection...
  54. ncbi Foamy virus capsid assembly occurs at a pericentriolar region through a cytoplasmic targeting/retention signal in Gag
    Shuyuarn F Yu
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Traffic 7:966-77. 2006
    ..Finally, inhibitor studies suggest an important role of microtubule networks for foamy viral assembly and budding...
  55. pmc Amino acid residues in the cytoplasmic domain of the Mason-Pfizer monkey virus glycoprotein critical for its incorporation into virions
    Chisu Song
    Department of Microbiology, University of Alabama at Birmingham, 35294, USA
    J Virol 79:11559-68. 2005
    ..These results demonstrate that the cytoplasmic domain of M-PMV Env, in part through its YXXL-mediated endocytosis and intracellular trafficking signals, plays a critical role in the incorporation of glycoprotein into virions...
  56. pmc Distinct roles for nucleic acid in in vitro assembly of purified Mason-Pfizer monkey virus CANC proteins
    Pavel Ulbrich
    Department of Biochemistry and Microbiology, Institute of Chemical Technology, Technicka 3, 166 28 Prague, Czech Republic
    J Virol 80:7089-99. 2006
    ..Thus, oligonucleotides may, through a transient interaction, induce conformational changes that facilitate assembly, while longer RNAs appear to facilitate the complete assembly of spherical particles...
  57. pmc Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation
    Penelope Buxton
    The Macfarlane Burnet Institute for Medical Research and Public Health, Cnr Punt and Commercial Rds, Melbourne, Victoria, Australia 3004
    J Virol 79:6338-48. 2005
    ....
  58. ncbi A virus causes cancer by inducing massive chromosomal instability through cell fusion
    Dominik M Duelli
    Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 17:431-7. 2007
    ..Because many viruses are fusogenic, this study suggests that viruses, including those that have not been linked to carcinogenesis, can cause chromosomal instability and, consequently, cancer by fusing cells...
  59. ncbi Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS
    Benoit Callendret
    Unite de Genetique Moleculaire des Virus Respiratoires, URA CNRS 1966, EA 302 Université Paris 7, France
    Virology 363:288-302. 2007
    ..Our observations are likely to be useful for the construction of plasmid and viral vectors designed for optimal expression of intronless genes derived from cytoplasmic RNA viruses...
  60. ncbi Role of Mason-Pfizer Monkey Virus CA-NC Spacer Peptide-Like Domain in Assembly of Immature Particles
    Karolína Strohalmová-Bohmová
    Institute of Organic Chemistry and Biochemistry IOCB Research Centre and Gilead Sciences, Academy of Sciences of the Czech Republic, v v i, Flemingovo nam 2, 166 10, Prague 6, Czech Republic Department of Biochemistry and Microbiology, Institute of Chemical Technology, Technická 5, Prague, Czech Republic
    J Virol 88:14148-60. 2014
    ..Using 8-Ã… cryo-electron microscopy density maps of immature M-PMV particles, we prepared computational models of the SP-like domain and indicate the structural features required for M-PMV immature particle assembly...
  61. ncbi Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors
    T Maetzig
    Department of Experimental Hematology, Hannover Medical School, Hannover, Germany
    Gene Ther 17:400-11. 2010
    ..This allowed for the tracking of chemoprotected and recombined cells by fluorescence marker expression...
  62. ncbi Rescue of internal scaffold-deleted Mason-Pfizer monkey virus particle production by plasma membrane targeting
    Michael Sakalian
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Boulevard, Oklahoma City, 73104, USA
    Virology 345:317-27. 2006
    ..These results provide support for a model in which the plasma membrane and the D-type ISD provide an interchangeable scaffold-like function in retrovirus assembly...
  63. pmc Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes
    A S Zolotukhin
    Human Retrovirus Pathogenesis Group, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201
    J Virol 68:7944-52. 1994
    ..The data also suggest that Rev acts exclusively through the RRE interaction and that it does not have any additional essential function in the life cycle of the virus...
  64. ncbi Rev/RRE-independent Mason-Pfizer monkey virus constitutive transport element-dependent propagation of SIVmac239 vectors using a single round of replication assay
    T A Rizvi
    Department of Veterinary Sciences, University of Texas M D Anderson Cancer Center, Bastrop 78602, USA
    Virology 222:457-63. 1996
    ..Our results demonstrate that MPMV CTE is capable of substituting for SIV Rev and RRE functions, resulting in an attenuated ability to produce infectious virus...
  65. ncbi Characterization of infectious type D retrovirus from baboons
    R F Grant
    Regional Primate Research Center, University of Washington, Seattle 98195
    Virology 207:292-6. 1995
    ..The homologies in the p27 segment were 91-94% and the homologies in the gp20 segment were 72-75%...
  66. pmc Retroviral nucleocapsid proteins possess potent nucleic acid strand renaturation activity
    F Dib-Hajj
    Department of Biochemistry and Biophysics, Texas A and M University, College Station 77843 2128
    Protein Sci 2:231-43. 1993
    ..The finding of significant nucleic acid strand renaturation activity may have important implications for various events of reverse transcription particularly in initiation and cDNA strand transfer...
  67. pmc Functional involvement of a novel Nedd4-like ubiquitin ligase on retrovirus budding
    Jiro Yasuda
    Division of Molecular Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    EMBO Rep 3:636-40. 2002
    ..Our observations provide new insights into the mechanism of virus budding, and could be useful in establishing new antiviral strategies targeted at progeny virus release from a host cell...
  68. pmc Retroviruses have differing requirements for proteasome function in the budding process
    David E Ott
    AIDS Vaccine Program, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    J Virol 77:3384-93. 2003
    ....
  69. ncbi Proteolytic processing of particle-associated retroviral polyproteins by homologous and heterologous viral proteinases
    J Konvalinka
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Eur J Biochem 228:191-8. 1995
    ..4 microM. The PR of Mason Pfizer monkey virus cleaved this polyprotein very poorly, whereas PR of bovine leukemia virus cleaved it, albeit at ..
  70. pmc Cellular motor protein KIF-4 associates with retroviral Gag
    Y Tang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:10508-13. 1999
    ..The binding of Gag is mediated by a domain of KIF-4 proximal to the C terminus. These results, and our previous studies, raise the possibility that KIF-4 may play an important role in retrovirus Gag protein transport...
  71. pmc Crystal structures of beta- and gammaretrovirus fusion proteins reveal a role for electrostatic stapling in viral entry
    Halil Aydin
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    J Virol 88:143-53. 2014
    ..Our data indicate that salt bridges are a major stabilizing force on the MPMV and XMRV retroviral TMs and likely provide the key energetics for viral and host membrane fusion. ..
  72. pmc A cell-based method for screening RNA-protein interactions: identification of constitutive transport element-interacting proteins
    ROBERT L NAKAMURA
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e48194. 2012
    ..This "Tat-hybrid" screening platform was used to identify proteins that interact with the Mason Pfizer monkey virus (MPMV) constitutive transport element (CTE), a structured RNA hairpin that mediates the transport of ..
  73. pmc The G-patch domain of Mason-Pfizer monkey virus is a part of reverse transcriptase
    Ivana Krízová
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, vvi, IOCB and Gilead Research Center, Prague, Czech Republic
    J Virol 86:1988-98. 2012
    ..Immunoprecipitation experiments suggested that the GPD is a part of RT and participates in its function. These data indicate that the M-PMV GPD functions as a part of reverse transcriptase rather than protease...
  74. pmc A hepadnavirus regulatory element enhances expression of a type 2 bovine viral diarrhea virus E2 protein from a bovine herpesvirus 1 vector
    Lingshu Wang
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 77:8775-82. 2003
    ....
  75. ncbi Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy
    Tanmay A M Bharat
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 487:385-9. 2012
    ....
  76. ncbi Nucleotide sequence of Mason-Pfizer monkey virus: an immunosuppressive D-type retrovirus
    P Sonigo
    Cell 45:375-85. 1986
    ..While MPMV-like viruses cannot be used as direct models for the AIDS/SAIDS associated with lentiviruses, they provide an important system for studying the molecular basis of immunosuppressive diseases in primates...
  77. pmc Defining the DNA substrate binding sites on HIV-1 integrase
    James Dolan
    Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Mol Biol 385:568-79. 2009
    ..Mutations at seven other residues reported in the literature have the same phenotype, and all eight residues align along the length of the putative target DNA binding trench...
  78. pmc The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity
    Marcela Wildová
    Gilead Sciences and IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Virology 380:157-63. 2008
    ..These data indicate that the region spanning residues Asp50-Asp57 plays an important role in stabilization of the beta-hairpin and that Asp57 likely forms a salt-bridge with P1 in M-PMV CA...
  79. pmc Amino acid preferences of retroviral proteases for amino-terminal positions in a type 1 cleavage site
    Helga Eizert
    University of Debrecen, Department of Biochemistry and Molecular Biology, Nagyerdei krt 98, Debrecen H 4012, Hungary
    J Virol 82:10111-7. 2008
    ..g., those of AMV and MMTV), the specificities of the primate lentiviral proteases substantially differed from that observed for a nonprimate lentiviral protease...
  80. pmc NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains
    Hyo Young Chung
    University of Utah, Department of Biochemistry, 15 N Medical Drive, East, Salt Lake City, UT 84112 5650, USA
    J Virol 82:4884-97. 2008
    ..These observations suggest that NEDD4L and possibly other NEDD4-like proteins can ubiquitylate and activate ESCRT-I to function in virus budding...
  81. ncbi Role of Mason-Pfizer monkey virus (MPMV) constitutive transport element (CTE) in the propagation of MPMV vectors by genetic complementation using homologous/heterologous env genes
    T A Rizvi
    University of Texas M D Anderson Cancer Center, Department of Veterinary Sciences, Bastrop 78602, USA
    Virology 224:517-32. 1996
    ..We conclude that CTE is important in the replication of MPMV and affects the nucleocytoplasmic transport and/or stability of viral messages similar to the Rev/RRE regulatory system of HIV-1 and SIV...
  82. ncbi Identification and purification of cellular proteins that specifically interact with the RNA constitutive transport elements from retrovirus D
    H Tang
    Department of Biology, University of California, San Diego, La Jolla 92093 0665, USA
    Virology 228:333-9. 1997
    ..Both proteins have been partially purified. The nature of these proteins and their roles in RNA intracellular trafficking are currently under investigation...
  83. pmc The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly
    M R Conte
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, University of London, London SW7 2AY, UK
    EMBO J 16:5819-26. 1997
    ..In addition to this, the interpretation of mutagenesis data has enabled us to identify, for the first time, the structural basis of a putative intracellular targeting motif...
  84. pmc Multimerization of the p12 domain is necessary for Mason-Pfizer monkey virus Gag assembly in vitro
    Zdenek Knejzlík
    Department of Biochemistry and Microbiology and Center for Integrated Genomics, Institute of Chemical Technology, Prague 166 28, Czech Republic
    Virology 365:260-70. 2007
    ..These data highlight the importance of a region containing alternating leucines and isoleucines within p12, but also indicate that this domain's scaffold-like function is more complex than small number oligomerization...
  85. pmc The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus
    Zdena Kohoutová
    Department of Biochemistry and Microbiology and the Center for Integrated Genomics, Institute of Chemical Technology, Prague, Czech Republic
    Virology 384:59-68. 2009
    ..Gag-Pro-Pol polyprotein alone neither formed immature particles nor processed the precursor. All the mutants were non-infectious except the "HIV-like", which retained fractional infectivity...
  86. ncbi Serological survey for type D retroviruses and simian immunodeficiency virus in monkeys living in Hungary
    A Gyuris
    , Microbiological Research Group, Budapest, Hungary
    Acta Vet Hung 41:171-7. 1993
    ..None of the sera tested proved to be positive for the presence of type D retroviruses and only one serum of an African green monkey was positive for the presence of antibodies to SIV...
  87. pmc Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome
    Cheryl Bolinger
    Center for Retrovirus Research, Department of Veterinary Biosciences, Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH, USA
    Retrovirology 6:8. 2009
    ..In a broad perspective, each new insight offers a prospective target for antiviral therapy and strategic improvement of gene transfer vectors...
  88. ncbi Antibodies to gag gene coded polypeptides of type D retroviruses in healthy people from Guinea-Bissau
    V A Morozov
    UPR 0043 CNRS, , , France
    Intervirology 32:253-7. 1991
    ..In eight (25%) sera antibodies at least against p36 were detected. Among squirrel monkey retrovirus positive sera, three were also positive with p27 M-PMV. The other five were found to be M-PMV negative...
  89. ncbi A single amino acid substitution within the matrix protein of a type D retrovirus converts its morphogenesis to that of a type C retrovirus
    S S Rhee
    Department of Microbiology, University of Alabama, Birmingham 35294
    Cell 63:77-86. 1990
    ..Thus, capsid assembly processes for different retroviruses appear to differ only in the intracellular site to which capsid precursors are directed...
  90. pmc Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA
    Kalpana Rajanala
    National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
    PLoS ONE 7:e29921. 2012
    ..Export of intron-containing mRNA in Mason Pfizer Monkey Virus is regulated by direct interaction of cellular proteins with the cis-acting Constitutive Transport ..
  91. ncbi The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element
    Jennifer E Swartz
    Myles H Thaler Center for AIDS and Human Retrovirus Research and Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:19844-53. 2007
    ..These results provide further evidence for crucial links between RNA splicing, export and translation...
  92. pmc High-resolution structure of a retroviral protease folded as a monomer
    Miroslaw Gilski
    Department of Crystallography, Faculty of Chemistry, A Mickiewicz University, 60 780 Poznan, Poland
    Acta Crystallogr D Biol Crystallogr 67:907-14. 2011
    ..6 Å) provides important extra information for the design of dimerization inhibitors that might be developed as drugs for the treatment of retroviral infections, including AIDS...
  93. pmc Oligomerization of a retroviral matrix protein is facilitated by backbone flexibility on nanosecond time scale
    Pavel Srb
    Department of Low Temperature Physics, Faculty of Mathematics and Physics, Charles University, V Holešovičkách 2, 18000 Prague, Czech Republic
    J Phys Chem B 115:2634-44. 2011
    ..Our results document that conformational selection mechanism together with induced fit and favorable structural preorganization play an important role in the control of the oligomerization process...
  94. pmc Assembly mechanisms of RNA pseudoknots are determined by the stabilities of constituent secondary structures
    Samuel S Cho
    Biophysics Program, Institute for Physical Science and Technology, and Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 106:17349-54. 2009
    ..We also establish that assembly mechanisms can be predicted using the stabilities of the isolated secondary structures...
  95. ncbi Conformational changes of the N-terminal part of Mason-Pfizer monkey virus p12 protein during multimerization
    Zdenek Knejzlík
    Department of Biochemistry and Microbiology, Institute of Chemical Technology, Technicka 5, 166 28 Prague 6, Czech Republic
    Virology 393:168-76. 2009
    ..Assembly into fibers is linked to a conformational transition from unfolded or another non-periodical state to alpha-helix during multimerization...
  96. ncbi Identification of a generalised packaging sequence for D-type retroviruses and generation of a D-type retroviral vector
    R G Vile
    Department of Communicable Diseases, St Mary s Hospital Medical School, London, U K
    Virology 189:786-91. 1992
    ..Hence, we have localized a packaging sequence that is recognized by D-type, but not by C-type, retroviruses and have constructed a D-type vector which may be useful in gene transfer experiments...
  97. ncbi 1H, 13C, and 15N resonance assignment of the N-terminal domain of Mason-Pfizer monkey virus capsid protein, CA 1-140
    Pavel Macek
    Faculty of Science, National Centre for Biomolecular Research, Masaryk University, Kotlarska 2, 61137 Brno, Czech Republic
    Biomol NMR Assign 2:43-5. 2008
    ..As a first step toward the solution structure elucidation, we present nearly complete backbone and side-chain 1H, 13C and 15N resonance assignment of the M-PMV NTD CA...
  98. ncbi Nonmyristoylated matrix protein from the Mason-Pfizer monkey virus forms oligomers
    Jiří Vlach
    Institute of Chemical Technology, Prague, Czech Republic
    J Mol Biol 390:967-80. 2009
    ..3 and 0.24 mM, respectively. Structures of the oligomers calculated with HADDOCK software are closely related to the structures of other retroviral MA trimers...
  99. ncbi Detection of squirrel monkey retroviral sequences in interferon samples
    M Pienkowska
    Laboratory of Molecular Pathology, Women s College Hospital, Toronto, Ontario, Canada
    J Hepatol 28:396-403. 1998
    ..However, it remains to be determined whether the residual DNA sequences detected by our sensitive nested polymerase chain reaction assay have biological consequences...
  100. pmc Tap and Dbp5, but not Gag, are involved in DR-mediated nuclear export of unspliced Rous sarcoma virus RNA
    Jason J LeBlanc
    Department of Biology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Virology 363:376-86. 2007
    ..Taken together, these results further implicate the DR in nuclear RNA export through interactions with Tap and Dbp5...
  101. ncbi The RNA binding G-patch domain in retroviral protease is important for infectivity and D-type morphogenesis of Mason-Pfizer monkey virus
    Helena Bauerová-Zábranská
    Centre for New Antivirals and Antineoplastics, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague
    J Biol Chem 280:42106-12. 2005
    ....

Research Grants11

  1. Evaluation of RNA transport elements in HIV-1 vectors
    SRINIVAS KUMAR; Fiscal Year: 2007
    ..This, in turn, will allow us to devise high-titer lentivirus-based packaging systems with a reduced chance of generating replication competent virus. ..
  2. SIMIAN RETROVIRUSES--NOVEL GENE DELIVERY VECTORS
    CURTIS MACHIDA; Fiscal Year: 1999
    ....
  3. GENETICS OF PRIMATE D TYPE RETROVIRUSES
    Eric Hunter; Fiscal Year: 1999
    ..Deletion, insertion, and point mutagenesis procedures will be employed for these studies. The role of the envelope glycoproteins in directing the budding and release of viral particales will be investigated utilizing similar procedures. ..
  4. GENETICS OF PRIMATE D TYPE RETROVIRUSES
    Eric Hunter; Fiscal Year: 2001
    ..Screen for inhibitors of the proteinase using a combinatorial peptide library; 2d. Crystallize and determine the structure of the different forms of the proteinase. ..
  5. REGULATION OF HIV RNA PROCESSING AND TRANSPORT
    Marie Louise Hammarskjold; Fiscal Year: 2002
    ..An understanding of how retroviral RNA export relates to export of cellular RNAs may allow us to design novel inhibitors with selective effects. ..
  6. HOST CELL PROTEINS IN RETROVIRAL ASSEMBLY & TRANSPORT
    Rachel LaCasse; Fiscal Year: 2002
    ..abstract_text> ..
  7. Sam 68 and the Function of Mason Pfizer Monkey Virus CTE
    Marie Louise Hammarskjold; Fiscal Year: 2007
    ..Aim 4: To identify and characterize in vivo cellular mRNA targets of Sam68. ..
  8. IN VITRO ASSEMBLY AND INHIBITION OF HIV CAPSIDS
    Michael Sakalian; Fiscal Year: 2001
    ....
  9. TRAINING IN VIRAL ONCOLOGY
    JANET MERTZ; Fiscal Year: 2005
    ....
  10. Regulation of Latent-Lytic Switch in EBV by ZEB
    JANET MERTZ; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  11. Intracellular targeting of HIV Gag proteins
    ROBERT WELDON; Fiscal Year: 2005
    ..The results obtained from these studies will provide important information about how Gag proteins function within cells and may provide a framework for developing novel therapeutic strategies to combat HIV replication. ..